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Editorial 
Prof. Dr. Martín Aznar 
 
Neste número do Boletim da FEQ relatamos várias atividades importantes. 
No mês de marco recebemos a visita dos professores Richard M. Felder e 
Rebecca Brent, que ministraram um importante curso para professores e alunos de 
pós-graduação, versando sobre técnicas eficientes no ensino de engenharia. O curso 
foi importante não apenas pela relevância do assunto e pela qualidade dos 
professores, mas porque, além disso, foi transmitido por teleconferência e Internet 
para mais de dez universidades brasileiras, incluindo USP, UFSCar, UFRJ, UEM, 
UNESP, entre outras. Desta forma, o curso teve uma abrangência e um alcance sem 
precedentes, contribuindo decisivamente, esperamos, para a melhoria na qualidade 
de ensino a nível nacional. A vinda dos professores Felder e Brent teve o apoio do 
programa Escola de Altos Estudos da CAPES. 
Por outro lado, alunos da FEQ ganharam o primeiro lugar (mestrado) e o 
segundo lugar (doutorado) no Prêmio Nacional de Pós-Graduação Braskem/ABEQ, 
confirmando a qualidade das pesquisas desenvolvidas e a boa formação dos nossos 
alunos. As nossas felicitações aos alunos Yuri Pereira e Marcello Nitz, e aos seus 
respectivos orientadores, professores Liliane Lona e Osvaldir Taranto. 
Além disso, a Profa. Ângela Moraes lançou um livro sobre o cultivo de 
células animais, em co-autoria com professores do Brasil e do Canadá, editado pela 
Taylor & Francis. Escrever um livro técnico/científico é uma das tarefas mais 
difíceis, profundas e abrangentes que um pesquisador pode se propor; iniciativas 
como esta reforçam o papel internacional da FEQ como uma escola de ponta. 
Em outro contexto, um workshop sobre montagem de um coletor solar de 
baixo custo, desenvolvido pelo Prof. Julio Bártoli e o seu orientado Renato César 
Pereira, teve ampla repercussão na mídia, com matérias veiculadas na EPTV e no 
SBT. O equipamento, de baixo custo e fácil instalação, é dirigido a famílias de baixa 
renda e já está sendo implantado em projetos sociais na região de Barão Geraldo. 
Por último, oito patentes/softwares foram depositadas em 2007 junto ao 
Instituto Nacional da Propriedade Industrial (INPI). 
Atividades tão importantes e tão distintas mostram a enorme 
heterogeneidade da FEQ e a força da sua pesquisa, ensino e extensão. 
 
N E S T E N ÚM E RO 
1 Editorial 
1 Palestras na FEQ 
2 Artigos publicados em 
Janeiro-Março 2008 
9 Patentes e registros 
10 Teses e dissertações 
11 Notas curtas 
 
Escola de Altos Estudos 
Prêmio Braskem/ABEQ 
Coletor solar 
Livro internacional 
Sete patentes em 2007 
15 de abri l de 2008 
Ano 2 Número 5 
Uma publ icação da Facu ldade de Engenharia Química da UNICAMP 
Av. Albert Einstein 500, Campinas-SP, 13081-970 
Editor: P rof. Dr. Mart ín Aznar, bolet imfeq@feq.unicamp.br, fone 3521-3962 
Boletim da 
FEQ 
 
 
Palestras na FEQ 
 
� Dr. Marcel Wubbolts, DSM White Biotechnology, DSM Innovation Center, Delft (Holanda). “Industrial 
Biotechnology - The Next Revolution”. 10/03/2008. 
� Dr. Rodolfo Quintero, Universidad Autónoma Metropolitana (México). “Estado Actual de las 
Investigaciones relacionadas con la Hidrólisis Enzimática para la Producción de Etanol”. 12/03/2008. 
 
 
Página 2 Boletim da FEQ
Artigos Publicados em Revistas Indexadas 
Janeiro-Março 2008 
 
Bases de dados: ISI Web of Knowledge, Sci Finder Scholar, Compendex, SciELO, Scopus, Scirus. 
 
Janeiro 
 
Computation and modeling of critical phenomena with the perturbed chain – statistical associating fluid 
theory equation of state 
Arce, P.F.; Aznar, M. Journal of Supercritical Fluids, 43 (2008), 408-420. ISSN: 0896-8446. 
Critical phenomena such as co-solvency, miscibility windows and two-phase holes in the three-phase surfaces 
can be of great importance in industrial applications of near-critical and supercritical technology, since they 
occur in a range of temperatures, pressures and compositions where the technological processes are carried out. 
They are also very important for mapping the transitions between different types of fluid phase behavior. In this 
work, the perturbed chain-statistical associating fluid theory (PC-SAFT) equation of state was used to model the 
critical phenomena of various ternary systems and their respective binary subsystems (which include n-alkanes, 
n-alkanols, aromatic alcohols and carbon dioxide) by fitting binary interaction parameters (kij). The 
experimental data covered a range of temperatures and pressures of practical interest in engineering. Results 
were compared with experimental critical data obtained from literature and an excellent agreement was 
obtained. An algorithm to calculate numerically the double critical endpoints and tricritical points according to 
their thermodynamic definitions was also developed. 
 
Modelling and simulation of a gas–solids dispersion flow in a high-flux circulating fluidized bed (HFCFB) riser 
Bastos, J.C.S.C.; Rosa, L.M.; Mori, M.; Marini, F.; Martignoni, W.P. Catalysis Today, 130 (2008), 462-470. ISSN: 
0920-5861. 
Radial solids velocity profiles were computed on seven axial levels in the riser of a high-flux circulating fluidized 
bed (HFCFB) using a two-phase 3-D computational fluid dynamics model. The computed solids velocities were 
compared with experimental data on a riser with an internal diameter of 76 mm and a height of 10 m, at a high 
solids flux of 300 kg m−2 s−1 and a superficial velocity of 8 m s−1. Several hundreds of experimental and numerical 
studies on CFBs have been carried out at low fluxes of less than 200 kg m−2 s−1, whereas only a few limited useful 
studies have dealt with high solids flux. The k– two-phase turbulence model was used to describe the gas–solids 
flow in an HFCFB. The model predicts a core–annulus flow in the dilute and developed flow regions similar to 
that found experimentally, but in the region of highest solids concentration it is somewhat over predicted at the 
level close to the inlet. 
 
HPLC determination of pesticides in soybeans using matrix solid phase dispersion 
Maldaner, L.; Santana, C.C.; Jardim, I.S.F. Journal of Liquid Chromatography & Related Technologies, 31 
(2008), 972-983. ISSN: 1082-6076. 
A method to determine six pesticides applied in soy cultivation (imazethapyr, imazaquin, metsulfuron-methyl, 
carboxin, chlorimuron-ethyl, and tebuconazole) using matrix solid phase dispersion (MSPD) as the extraction 
technique followed by a clean-up step, using a C8 co-column, and subsequent chromatographic analysis by high 
performance liquid chromatography diode array detection (HPLC-DAD) was developed. The validated method 
showed good recuperation for all pesticides (60-120%), except for metsulfuron-methyl and tebuconazole at their 
lowest concentration levels, and the quantification limits of the method (0.04-0.08 µg g-1) were below the 
maximum residue limits imposed by the principal regulatory agencies. 
 
 
 
 
 
 
 
 
 
 
Boletim da FEQ Página 3 
 
A comparison between lime and alkaline hydrogen peroxide pretreatments of sugarcane bagasse for ethanol 
production 
Rabelo, S.C.; Maciel Filho, R.; Costa, A.C. Applied Biochemistry and Biotechnology, 144 (2008), 87-100. ISSN: 
0273-2289. 
Pretreatment procedures of sugarcane bagasse with lime (calcium hydroxide) or alkaline hydrogen peroxide 
were evaluated and compared. Analyses were performed using 23 factorial designs, with pretreatment time, 
temperature, and lime loading and hydrogen peroxide concentration as factors. The responses evaluated were 
the yield of total reducing sugars (TRS) and glucose released from pretreated bagasse after enzymatic 
hydrolysis. Experiments were performed using the bagasse, as it comes from an alcohol/sugar factory and 
bagasse, in the size, range from 0.248 to 1.397 mm (12–60 mesh). The results show that, when hexoses and 
pentoses are of interest, lime should be the pretreatment agent chosen, as high TRS yields are obtained for non-
screened bagasse using 0.40 g lime/g dry biomassat 70°C for 36 h. When the product of interest is glucose, the 
best results were obtained with lime pretreatment of screened bagasse. However, the results for alkaline 
peroxide and lime pretreatments of non-screened bagasse are not very different. 
 
Optimization of a large scale industrial reactor by genetic algorithms 
Rezende, M.C.A.F.; Costa, C.B.B.; Costa, A.C.; Wolf Maciel, M.R.; Maciel Filho, R. Chemical Engineering Science, 
63 (2008), 330-341. ISSN: 0009-2509. 
The present work aims to employ genetic algorithms (GAs) to optimize an industrial chemical process, 
characterized by being difficult to be optimized by conventional methods. The considered chemical process is 
the three phase catalytic slurry reactor in which the reaction of the hydrogenation of o-cresol producing 2-
methyl-cyclohexanol occurs. In order to describe the dynamic behavior of the multivariable process, a non-
linear mathematical model is used. Due to the high dimensionality and non-linearity of the model, a rigorous 
one, the solution of the optimization problem through conventional algorithms does not always lead to 
convergence. This fact justifies the use of an evolutionary method, based on the GAs, to deal with this process. 
In this way, in order to optimize the process, the GA code is coupled with the rigorous model of the reactor. The 
aim of the optimization through GAs is the searching of the process inputs that maximizes the productivity of 2-
methyl-cyclohexanol subject to the environmental constraint of conversion. Many simulations are conducted in 
order to find the maximization of the objective function without violating the constraint. The results show that 
the GAs are used successfully in the process optimization. The selection of the most important GA parameters 
making use of a factorial design approach by fractional factorial design is proposed. A factorial design approach 
by a central composite design is also proposed in order to determine the best values of the GA parameters that 
lead to the optimal solution of the optimization problem. 
 
Effect of IDA and TREN chelating agents and buffer systems on the purification of human IgG with 
immobilized nickel affinity membranes 
Ribeiro, M.B.; Vijayalakshmi, M.; Todorova-Balvay, D.; Bueno, S.M.A., Journal of Chromatography B, 861 (2008), 
64-73. ISSN: 1570-0232. 
The purification of IgG from human plasma was studied by comparing two affinity membranes complexed with 
Ni(II), prepared by coupling iminodiacetic acid (IDA) and Tris(2-aminoethyl)amine (TREN) to poly(ethylenevinyl 
alcohol), PEVA, hollow fiber membranes. The Ni(II)-TREN-PEVA hollow fiber membrane had lower capacity for 
human IgG than the complex Ni(II)-IDA-PEVA, but with similar selectivity. The IgG in peak fractions eluted from 
the Ni(II)-IDA-PEVA with a stepwise concentration gradient of Tris–HCl pH 7.0 (100–700 mM) reached a purity of 
98% (based on IgG, IgM, IgA, albumin, and transferrin nephelometric analysis). Adsorption IgG data at different 
temperatures (4–37°C) were analyzed using Langmuir model resulting in a calculated maximum capacity at 25°C 
of 204.6 mg of IgG/g of dry membrane. Decrease in Kd with increasing temperature (1.7 × 10
−5 to 5.3 × 10−6M) 
indicated an increase in affinity with increased temperature. The positive value of enthalpy change (26.2 
kJ/mol) indicated that the adsorption of IgG in affinity membrane is endothermic. Therefore, lower 
temperature induces adsorption as verified experimentally. 
 
 
 
 
 
Página 4 Boletim da FEQ
 
Coumarin solubility and extraction from emburana (Torresea cearensis) seeds with supercritical carbon 
dioxide 
Rodrigues, R.F.; Tashima, A.K.; Pereira, R.M.S.; Mohamed, R.S.; Cabral, F.A. Journal of Supercritical Fluids, 43 
(2008), 375-382. ISSN: 0896-8446. 
Coumarin is an active principle found in several vegetable species with a characteristic smell of vanilla. It is 
widely used as a perfume fixer, paint and spray additive, and in cleaning products. It also possesses clinical 
value due to antibiotic and analgesic properties, besides its potential use in the treatment of cancer and AIDS. 
The objective of this work was to obtain solubility data for coumarin under several conditions, as well as to 
evaluate process parameters for its extraction from emburana seeds with supercritical CO2. The process 
parameters studied were temperature, pressure, CO2 flow rate and particle size of the seeds. The solubility in 
supercritical CO2 was correlated using the Peng–Robinson equation. Solid-supercritical fluid and liquid-
supercritical fluid equilibria were considered and correlated separately, with L-SC presenting better results due 
to the effect of the melting point depression of coumarin under high pressure. The results showed significant 
effects of pressure and temperature on the extraction yield and also, the smaller the particle size of the seeds, 
the better the yield. 
 
CFD analysis of cyclone separators connected in series 
Vegini, A.A.; Meier, H.F.; Iess, J.J.; Mori, M. Industrial & Engineering Chemistry Research, 47 (2008), 192-200. 
ISSN: 0888-5885. 
Cyclone separators are very useful equipment for particle removal from gaseous streams. Their simple design 
and low capital and maintenance costs have made cyclones one of the most widely used gas-solid separators. 
Their dynamic behavior includes several phenomena, such as vortex breakdown, reversal of flow, and high 
turbulence intensity. Prediction of pressure drop and collection efficiency over a temperature range of several 
hundred degrees with a high solids loading flow and different cyclone dimensions is very difficult with simplified 
models. In this work, a model that is based on computational fluid dynamics (CFD) techniques is used to verify 
the performance of cyclone separators connected in series; this collection of separators is called a cyclone 
tower. The model is based on the Eulerian-Eulerian approach, and it is composed of several time differential 
equations in a two-dimensional (2-D) space domain with a three-dimensional (3-D) symmetric cyclone inlet. The 
model is solved using the finite volume method with staggered grids. The results on collection efficiency and 
pressure drop of an experimental study were used to validate the proposed model. After validation of the 
model, it was possible to examine the performance of the cyclone separators through a comparison of the 
numerical results and information obtained in the cement industry. 
 
 
Fevereiro 
 
Development of a mathematical model for bioethanol-water separation using hydrophilic polyetherimide 
membrane 
Alvarez, M.E.T.; Moraes, E.B.; Araujo, W.A.; Maciel Filho, R.; Wolf-Maciel, M.R. Journal of Applied Polymer 
Science, 107 (2008), 2256-2265. ISSN: 0021-8995. 
An essentially predictive mathematical model was developed to simulate pervaporation process. The group 
contribution method UNIFAC was used for calculating the upstream activity coefficients. The diffusion 
coefficient in the membrane was predicted using free-volume theory. Free-volume parameters were determined 
with viscosity and temperature data, and the binary interaction solvent-polymer parameter was calculated by a 
group-contribution lattice-fluid equation of state (GCLF-EOS). A simulator named PERVAP was developed 
applying the mathematical model. Pervaporation process was simulated for separating bioethanol-water through 
polyetherimide membrane. The simulated results were validated using experimental data of bioethanol/water 
separation through polyetherimide membrane. The model presented a satisfactory performance compared to 
experimental data. Related to the simulation of the studied separation, a 99% molar enriched bioethanol stream 
was obtained with a recovery of 94%. 
 
 
 
 
 
Boletim da FEQ Página 5 
 
Modeling and simulation of high-pressure industrial autoclave polyethylene reactor 
Caliani, E.; Cavalcanti, M.; Lona. L.M.F.; Fernades, F.A.N. Express Polymer Letters, 2 (2008), 57-64. ISSN: 1788-618X. 
High-pressure technology for polyethylene production has been widely used by industries around the world. A 
good model for the reactor fluid dynamics is essential to set the operating conditions of an autoclave reactor. 
The high-pressure autoclave reactor model developed in this work was based on a non-isothermal dynamic 
model, where PID control equations are used to maintain the operation at the unstable steady state. The kinetic 
mechanism to describe the polymerization rate and molecular weight averages are presented. The model is 
capable of computing temperature, concentration gradients and polymer characteristics. The model was 
validated for an existing industrial reactor and data for production of homopolymer polyethylene and has 
represented well the behavior of the autoclave reactor used in ethylene homopolymerization. 
 
Superabsorbent hydrogel composed of covalently crosslinked gum arabic with fast swelling dynamics 
Favaro, S.L.; Oliveira, F.; Reis, A.V.; Guilherme, M.R.; Muniz, E.C.; Tambourgi , E.B. Journal of Applied Polymer 
Science, 107 (2008), 1500-1506. ISSN: 0021-8995. 
A superabsorbent hydrogel (SH) with fast swelling dynamics and good mechanical stability in the swollen state 
was prepared. The SH was obtained from chemically modified gum arabic (MGA) with glycidyl methacrylate 
(GMA), acrylic acid (AAc), and acrylamide (AAm). The water-transport mechanisms and equilibrium swelling 
ratio (SR) were the parameters used to describe the water-absorption profile of SH. A 23 factorial design with a 
central point was built to evaluate the influence of the chemical modification of gum arabic (GA) on the SH 
sensitivity to water. The main effects of the temperature and amount of GMA and the interaction effect of the 
temperature and amount of GMA on the SR responses were statistically significant. It was demonstrated that the 
amount of GMA had a more prominent effect on gel swelling. Lower elastic modulus values for the SH were 
found when a decreased amount of GMA was used (0.05 g), which produced an SH with a high SR capacity. The 
SH matrix consisting of 3.0 g of AAc, 0.5 g of AAm, and 0.5 g of MGA was more suitable to absorb a large amount 
of water (SR = 503.17 ± 22.65 within 60 min of water immersion) without its mechanical stability being affected. 
Better GA modifying conditions to produce such an SH were as follows: 60°C for the temperature, 24 h for the 
time of MGA, and 0.05 g for the amount of GMA. It exhibited a diffusional exponent higher than 0.89, which 
corresponded to the supercase II type of penetrating transport mechanism, indicating that its water-absorption 
mechanism exclusively depended on the macromolecular relaxation of the polymer chains. 
 
Characterization of urban aerosol in Campinas, São Paulo, Brazil 
Miranda, R.; Tomaz, E.; Atmospheric Research, 87 (2008), 147-157. ISSN: 0169-8095. 
A quantitative study was performed in Campinas, Brazil. Measurements were taken on an avenue with intense 
vehicle traffic in the city's downtown area from August 2003 to August 2004. A dichotomous sampler was 
employed for PM2.5 and PM10. Samples were collected for 24h at 3-day intervals. In addition, seasonal variations 
were investigated, using a MOUDI cascade impactor and VOC adsorption tubes, during a specific 5-day period in 
the summer of 2003 and the winter of 2004. The polycarbonate filters were analyzed by gravimetry, Particle 
Induced X-ray Emission (PIXE), ion chromatography and reflectance, to identify the mass concentration, 
elemental composition, ions and elemental carbon mass, respectively. The quartz filters were analyzed by 
gravimetry and thermal combustion carbon analysis to identify the mass concentration and carbon mass. Results 
showed an annual mean of 20.85, 10.68 and 10.17µg m−3 for PM10, PM2.5 and PM2.5–10, respectively. The cascade 
impactor provided mass distribution and revealed differences between the two seasons. The size distribution for 
chemical elements indicated soil-derived elements in the coarse fraction. PM winter concentrations were 
expected to be higher than those in summer, but that was not the case during the days of this study, when 
summer and winter concentrations were almost identical The PIXE analysis revealed metals and metal 
compounds, soil-derived elements, sulfates, carbonates, chlorides and other anthropogenic air-borne particles, 
supposing molecules in their usual composition. An analysis of the VOCs revealed benzene, toluene, p-xylene, n-
hexane, 2-metilhexane and n-nonane. A mass balance analysis indicated different classes, among which 
elemental carbon was the most abundant, followed by organic carbon, soil elements and industrial sources. 
 
 
 
 
Página 6 Boletim da FEQ
 
"In vitro" calcification of silk fibroin hydrogel 
Nogueira, G.M.; Aimoli, C.G.; Weska, R.F.; Nascimento, L.S.; Beppu, M.M. Key Engineering Materials, 361/363 
(2008), 503-506. ISSN: 1013-9826. 
Silk fibroin hydrogels were prepared and their potential to deposit calcium phosphates in vitro was observed. 
Pristine and lyophilized samples were tested in 1.5×SBF and 1.5×SBF. The results showed that silk fibroin 
hydrogels can induce calcium phosphate deposits both in the pristine and lyophilized form. However, the 
pristine silk fibroin hydrogel after calcification presented a fragile structure making it difficult to handle, while 
the lyophilized samples presented better resistance to handling. Calcium phosphates deposits were intense in 
samples submitted to tests in 1.5×SBF, however, few and isolated deposits were observed on samples submitted 
to tests in 1×SBF. The 3-D porous structure and the ability to deposit calcium phosphates, turn silk fibroin 
hydrogel a potential material suitable to use in biomimetic processes. 
 
A comparative study between β-TCP prepared by solid state reaction and by aqueous solution precipitation: 
Application in cements 
Oliveira, A.P.; Motisuke, M.; Leal, C.V.; Beppu, M.M. Key Engineering Materials, 361/363 (2008), 355-358. ISSN: 
1013-9826. 
It is well known that calcium phosphate compounds are widely used as bone substitute due to their 
biocompatibility and bioactivity. Furthermore, recent studies have shown that slight changes in morphology or 
crystal structure can lead to several in vivo behaviours. Therefore, the purpose of this study was to investigate 
two different β-TCP synthesis routes (solid state reaction and aqueous solution precipitation) and their 
consequences on the final cement properties. It was found out that both routes are equivalent as there were no 
significant differences on their cement properties, except for mechanical resistance. The latter difference can 
also be attributed to the difference on the particle size distributions of the obtained β-TCP. These facts indicate 
that solid state reaction route is more interesting given its simplicity and yield. 
 
Análise termodinâmica de um sistema de co-geração com gaseificação de licor negro: Influência da 
composic ̧ão do gás 
Santos, P.R.; D’Angelo, J.V.H. O Papel, 69 (2008), 45-59. ISSN: 0031-1057. 
Nos últimos anos, ampliações da capacidade de produção de indústrias de papel e celulose causaram aumento 
da quantidade de licor negro disponível para queima, gerando um efeito de estrangulamento na unidade de 
recuperação. Problemas freqüentes na caldeira de recuperação, tais como corrosão, incrustações e riscos de 
explosões, em função de altas velocidades de processamento, tornaram-se uma realidade preocupante. A vida 
útil das caldeiras de recuperação é outro fator importante, porque um grande número delas está próximo do seu 
fim. Neste trabalho, foi estudado um sistema de co-geração de energia com gaseificação de licor negro, a fim de 
auxiliar na avaliação da viabilidade técnica deste processo alternativo mediante a aplicação de método de 
acordo com a Segunda Lei da Termodinâmica. Para atingir este objetivo, uma simulação deste sistema de co-
geração foi realizada em um simulador comercial (HYSYS© 2.2),tendo sido analisada a influência da composição 
do gás proveniente do gaseificador sobre a taxa de exergia destruída no sistema de co-geração. Os resultados 
mostraram que a composição do gás produzido no gaseificador tem grande influência sobre a taxa de exergia 
destruída o processo, e que a água, o hidrogênio e o monóxido de carbono são os principais componentes 
relacionados com essa destruição. Isto foi verificado através de uma análise exergética, que mostrou que as 
maiores perdas ocorrem na câmara de combustão dos gases. O processo de gaseificação de licor negro está se 
tornando um processo alternativo real e qualquer estudo que contribua para a avaliação da sua viabilidade é 
importante. Este trabalho pretende fornecer alguns parâmetros, como condições operacionais do gaseificador e 
a taxa de exergia destruída nos componentes do ciclo, que poderão ser usados para desenvolver investigações 
adicionais sobre processos de gaseificação de licor negro. 
 
 
 
 
 
 
 
 
 
Boletim da FEQ Página 7 
 
Março 
 
Extraction of green coffee oil using supercritical carbon dioxide 
Azevedo, A.B.A.; Kieckbusch, T.G.; Tashima, A.K.; Mohamed, R.S.; Mazzafera, P.; Vieira de Melo, S.A.B. Journal 
of Supercritical Fluids, 44 (2008), 186-192. ISSN: 0896-8446. 
Supercritical CO2 extraction was used to refine coffee oil obtained by mechanical pressing. Extractions were 
carried out using 50–70°C and pressures ranging from 15.2 to 35.2MPa, with a CO2 flow rate of 1 standard L/min 
using a semi-continuous high-pressure extraction apparatus. Green coffee oil fractions were collected at fixed 
time intervals and the composition of each fraction was determined by HPLC analyses. Caffeine and traces of 
chlorogenic acid were detected in the first fractions while waxes remained in the extraction vessel. Compared 
with the original oil the triglyceride composition remained almost unchanged in the fractions. The results also 
indicate an increase of triglyceride and caffeine extraction with pressure. An increase in extraction temperature 
results in a retrograde behavior over the pressure range of 15.2–28.3 MPa. At pressures higher than 30 MPa the 
solubility behavior of coffee oil was apparently independent of the temperature. A good correlation of the 
solubility data of green coffee oil was obtained using the Chrastil equation. 
 
Prediction of copper (II) ions dynamic removal from a medium by using mathematical models with analytical 
solution 
Borba, C.E.; Silva, E.A.; Klen, M.R.F.; Kroumov, A.D.; Guirardello, R. Journal of Hazardous Materials, 152 
(2008), 366-372. ISSN: 0304-3894. 
A copper (II) ions biosorption by Sargassum sp. biomass was studied in a fixed bed column at 30°C and pH 3.5. 
The experimental curves were obtained for the following feed concentrations −2.08, 4.16, 6.42 and 12.72 
mmol/L of the copper ions. The mathematical models developed by Thomas and Bohart–Adams were used for 
description of ions sorption process in the column. The models principle hypothesis is that the mass transfer 
controlling stage of the process is the adsorption kinetics between sorbate and adsorbent. The phenomena such 
as intraparticle diffusion, a mass transfer external resistance and axial dispersion effects were out of 
considerations. Some of the models parameters were experimentally determined (ρB, , u0, C0) and the others 
were evaluated on the bases of the experimental data (ka1, ka2). The unique fitting parameter in all models was 
the adsorption kinetic constant. The identification procedure was based on the least square statistical method. 
Simulation results show that the models describe well a copper ions sorption process in a fixed bed column. The 
used models can be considered as useful tools for adsorption process design and optimization in fixed bed 
column by using algae biomass of Sargassum sp. as an adsorbent. 
 
Application of the Prigogine-Flory-Patterson model to excess molar enthalpy of binary liquid mixtures 
containing acetonitrile and 1-alkanol 
Galvão, A.C.; Francesconi, A.Z. Journal of Molecular Liquids, 139 (2008), 110-116. ISSN: 0167-7322. 
Excess molar enthalpy of acetonitrile + 1-pentanol and acetonitrile + 1-hexanol as a function of composition at 
288.15, 293.15, 298.15 and 303.15 K under atmospheric pressure were used to test the applicability of the 
Prigogine-Flory-Patterson (PFP) model. The model, with only one adjustable parameter, shows to be able to 
correlate the experimental data of the investigated mixtures within a standard deviation up to 163 Jmol-1. The 
interactional contribution of the model plays the main role to describe the excess molar enthalpy and its ability 
of multiproperty description is not observed for the studied systems. 
 
Prediction of cloud points of biodiesel 
Lopes, J.C.A.; Boros, L.; Krähenbühl, M.A.; Meirelles, A.J.A.; Daridon, J.L.; Pauly, J.; Marrucho, I.M.; Coutinho, 
J.A.P. Energy & Fuels, 22 (2008), 747-752. ISSN: 0887-0624. 
The predictive UNIQUAC model, previously applied with success to the description of wax formation in fossil 
fuels, is extended here to the modeling of the precipitation of saturated and unsaturated fatty acid 
methyl/ethyl esters. Correlations for the thermophysical properties of the fatty acid esters are proposed, and 
the model is evaluated against experimental data of binary mixtures. Despite the lack of accurate data for the 
cloud points of biodiesel, the results obtained here allow for an adequate evaluation of the model proposed, 
showing that it can produce good predictions of the cloud points of mixtures of fatty acid esters. 
 
 
Página 8 Boletim da FEQ
 
Thermal fluid dynamics analysis of gas–liquid flow on a distillation sieve tray 
Noriler, D.; Meier, H.F.; Barros, A.A.C.; Wolf Maciel, M.R. Chemical Engineering Journal, 136 (2008), 133-143. 
ISSN: 1385-8947. 
Conventional models for distillation columns are based on equilibrium and non-equilibrium stage concepts, and 
both consider the fluid dynamics in a macroscopic point of view. The main objective of this work is to apply a 
CFD model under Eulerian-Eulerian framework for gas–liquid flows, with capability to predict the momentum and 
thermal phenomena of the multiphase flows. A three-dimensional and transient model with energy and 
momentum conservation balances has been applied for predictions of volume fractions, velocities, pressure and 
temperature fields of two-phase flows on sieve tray distillation. The mathematical model was applied in the CFD 
commercial code for numerical studies, with the construction of a particular numerical grid and with own sub-
routines in FORTRAN language for the closures equations obtained from literature. The model is solved using the 
finite-volume method with variables located in a generalized co-ordinate system for typical operating conditions 
taken from the literature. The results show the volume fractions, velocities and temperature profiles as a 
function of the time and the position in the distillation sieve tray and when are compared with the literature 
comments confirm that the model is suitable to predict thermal gas–liquid flows on a distillation sieve tray. 
 
Detection of the minimum gas velocity region using Gaussian spectral pressure distribution in a gas-solid 
fluidized bed 
Parise, M.R.; Taranto, O.P.; Kurka, P.R.G.; Benetti, L.B. Powder Technology, 82 (2008), 453-458. ISSN: 0032-
5910. 
The undesired phenomenon of partial or complete defluidizing can occur in industrial applications involving 
fluidized beds. That could be prevented by increasing the gas velocity, provided an adequate observation of 
changes in the hydrodynamic of the fluidized bed is detected early enough. Since the value of gas velocity on 
defluidization of bed is near the gas velocity at minimum fluidization condition, it is very important to use a 
methodology that can promptly detect the minimum fluidization velocity region, so that shutting down the 
process can be avoided. The literature shows that the methodsto detect the region of such a velocity are 
limited, and in practice, the traditional method for determination of minimum fluidization velocity (pressure 
drop across the bed versus superficial gas velocity) is still the most used. In the present work, a methodology is 
proposed to detect the region where the minimum velocity takes place in a gas–solid fluidized bed, based on the 
spectral analysis of pressure fluctuation measurements using a Gaussian distribution curve. Results indicate that 
the method is satisfactory, and it could be used as a more practical indicator of the region where the 
defluidization phenomenon occurs. 
 
Liquid–liquid equilibria of the ternary system water + acrylic acid + 4-methyl-2-pentanone at 298.15 K 
Pinto, G.M.F.; Machado, A.B.; Camacho-Ardila, Y.; Aznar, M.; Wolf-Maciel, M.R. Journal of Chemical & 
Engineering Data, 53 (2008), 659-662. ISSN: 0021-9568. 
In this work, experimental liquid–liquid equilibrium data for the ternary system water + acrylic acid + 4-methyl-
2-pentanone were determined at 298.15 K and atmospheric pressure. The experimental data were also 
compared with the values correlated by the NRTL and UNIQUAC models. Good quantitative agreement was 
obtained with these models. In general, the average deviations from the NRTL model are slightly greater than 
those from the UNIQUAC model. The reliability of the experimental tie-line data was confirmed by using the 
Othmer−Tobias correlation. Distribution coefficients and selectivity were evaluated for the immiscibility region. 
 
Boletim da FEQ Página 9 
Patentes e Registros 2007 
 
Fonte: Agência Inova 
 
Processo de enriquecimento de piperonal. 
Marco Aurélio Cremasco e Nazareno de Pina Braga. PI0701707-3. 
 
Processo de clarificação e enriquecimento de óleo cítrico. 
Gláucia Maria Ferreira Pinto, Rubens Maciel Filho, Maria Regina Wolf Maciel, Jefferson Ferreira Pinto e César 
Benedito Batistella. PI0701771-5. 
 
Processo de enriquecimento de safrol. 
Marco Aurélio Cremasco e Nazareno de Pina Braga. PI0701772-3. 
 
Método e procedimento para extração em fase sólida utilizando argila como sorvente. 
Gláucia Maria Ferreira Pinto e Talita Katiuska Takizawa Dias. PI0703838-0. 
 
Grânulos mucoadesivos contendo nano e/ou microesferas de quitosana e processo de obtenção de grânulos 
mucoadesivos. 
Maria Helena Andrade Santana, Classius Ferreira da Silva e Fernanda Martins. PI0705072-0. 
 
Configuração lipossomal funcional e processo de obtenção de configuração lipossomal funcional. 
Lucimara Gaziola de la Torre, Maria Helena Andrade Santana, Rogério Silva Rosada, Arlete A.M. Coelho Castelo e 
Célio Lopes Silva. PI0705630-3. 
 
Processo de extração de compostos ativos de material vegetal. 
Vanessa Mendes Santos Cavalcanti, Frederico Guaré Cruz, Martín Aznar, Silvio Alexandre Beisl Vieira de Melo e 
Sergio Delarcina Jr. Protocolo 018080015741. 
 
Software LIOMAT. Rubens Maciel Filho e Edinara Adelaide Boss. Registro 00082450. 
 
 
 
 
 
 
Página 10 Boletim da FEQ
Teses e Dissertações 
Janeiro-Março 2008 
 
Mestrado: 
 
695. Valéria do Carmo Barbosa. Estudo da fotopolimerização e degradação de um oligômero uretano acrilado 
alifático para aplicação em revestimentos para madeira. Orientador: Profa. Dra. Lúcia Helena Innocentini Mei. 
Defesa: 28/01/2008. 
 
696. Lívia Cordi. Estudo da biodegradação dos filmes de poli (e-caprolactona), da blenda poli (e-
caprolactona)/amido e do compósito poli (e-caprolactona)/amido/pó de fibra de coco por fungos e bactérias. 
Orientadores: Profa. Dra. Lúcia Helena Innocentini Mei e Prof. Dr. Nelson Eduardo Duran Caballero 
(IQ/UNICAMP). Defesa: 12/02/2008. 
 
697. Renato Prado Dionísio. Simulação tridimensional de uma coluna de bolhas – diferentes abordagens 
geométricas e modelagem. Orientador: Prof. Dr. Milton Mori. Defesa: 12/02/2008. 
 
698. Fábio Marini. Simulação de um leito fluidizado aplicando a técnica CFD baseada na teoria cinética do 
escoamento granular. Orientador: Prof.Dr. Milton Mori. Defesa: 13/02/2008. 
 
699. Érica Vagetti Fonseca. Obtenção de acrilatos de frutose por catálise enzimática. Orientador: Profa. Dra. 
Telma Teixeira Franco. Defesa: 28/02/2008. 
 
700. Tatiane Dias Marques Faria. Adesivo de borracha termoplástica reforçado com nanoargila. Orientador: Prof. 
Dr. Júlio Roberto Bartoli. Defesa: 28/02/2008. 
 
701. Rodolfo Cardoso de Jesus. Processamento e caracterização de biocompósitos de PHB com fibras naturais de 
coco e sisal acetiladas e não-acetiladas. Orientador: Profa. Dra. Lúcia Helena Innocentini Mei. Defesa: 
29/02/2008. 
 
702. Stella Alonso Rocha. Cálculo do equilíbrio de fases sólido-líquido em misturas binárias por meio de técnicas 
de minimização e análise de convexidade. Orientador: Prof. Dr. Reginaldo Guirardello. Defesa: 19/03/2008. 
 
 
Doutorado: 
 
363. Rodrigo Koerich Decker. Análise de estruturas coerentes de larga escala em jatos de dispersão bifásicos. 
Orientadores: Prof. Dr. Milton Mori, Prof. Dr. Henry França Méier (FURB) e Prof. Dr. Udo Fritsching (Universidade 
de Bremen, Alemanha). Defesa: 08/02/2008. 
 
364. André Luís Ferrari de Moura Giraldi. Compósitos híbridos de poli (tereftalato de etileno) (PET) / fibra de 
vidro (FV) / modificador de impacto (E-MA-GMA). Orientador: Profa. Dra. Lúcia Helena Innocentini e Prof. Dr. 
José Alexandrino de Sousa (UFSCar). Defesa:21/02/2008. 
 
365. Diógenes Ganghis Pimentel de Lyra. Modelo integrado de gestão de qualidade do ar da região metropolitana 
de Salvador. Orientador: Prof. Dr. Edson Tomaz. Defesa: 27/02/2008. 
 
366. Ana Clélia Ferreira. Modelos de otimização na produção de óleo diesel: uma aplicação industrial. 
Orientador: Profa. Dra. Maria Regina Wolf Maciel. Defesa: 27/02/2008. 
 
367. Rodrigo Silveira Vieira. Adsorção competitiva dos íons cobre e mercúrio em membranas de quitosana 
natural e reticulada. Orientador: Profa. Dra. Marisa Masumi Beppu e Prof. Dr. Eric Guibal (Ècole de Mines 
D´Alès, França). Defesa: 28/03/2008. 
 
 
Boletim da FEQ Página 11 
Notas curtas 
Curso para construção de coletor solar de baixo custo 
No dia 15 de março foi realizado na FEQ o primeiro 
curso para construção de um coletor solar de baixo 
custo para aquecimento de água. O coletor, 
denominado Sole Mio e desenvolvido pelo Prof. Dr. 
Julio Bártoli, do Departamento de Tecnologia de 
Polímeros, e o doutorando Renato César Pereira, é 
composto de materiais extremamente simples e 
baratos (canos e forros de PVC), é de fácil construção 
e está destinado a famílias de baixa renda. O 
equipamento consegue aquecer a água de 20 a 25°C 
acima da temperatura ambiente, dependendo dos 
ventos e da quantidade de luz solar. O primeiro 
protótipo foi montado na Casa de Repouso Bom 
Pastor, entidade assistencial sediada em Barão 
Geraldo, com intermediação da PROPEQ, empresa 
júnior da FEQ. Também participaram do projeto os 
alunos de graduação Valdir Assis Jr., Samuel Mello, 
Robson Shiota e Matheus de Rossi Carminatti, como 
iniciação científica. Matérias sobre o tema foram 
apresentadas na EPTV, no SBT e na TV Século 21. O 
coletor foi escolhido pela Replan para ser apresentado 
na semana sobre conservação de energia, a ser 
realizada na segunda semana de abril. Futuros 
oferecimentos do curso estão sendo programados pela 
Diretoria Social da PROPEQ com cooperativas de 
reciclagem na região de Campinas (em geral, estas 
pessoas ganham menos de 2 salários mínimos). Um 
manual simples para construção do coletor Sole Mio 
está disponível na seção de reprografia da FEQ. 
 
 
Diagrama esquemático do coletor solar 
 
 
Alunos da FEQ ganham o Prêmio Nacional de Pós Graduação Braskem/ABEQ 2006 
 
O aluno Yuri Guerrieri Pereira conquistou o primeiro lugar na 
categoria mestrado do Prêmio Nacional de Pós-Graduação 
Braskem/ABEQ. A premiação foi conferida pelo trabalho 
“Modelagem e simulação do equilíbrio de fases em plantas de 
polietileno utilizando a equação de estado PC-SAFT”, orientado 
pela Profa. Dra. Liliane Lona, do Departamento de Processos 
Químicos. Na categoriadoutorado, o aluno Marcello Nitz 
conquistou o segundo lugar pela tese “Fluidodinâmica, secagem e 
recobrimento em leito pulso-fluidizado", orientada pelo Prof. Dr. 
Osvaldir P. Taranto, do Departamento de Termofluidodinâmica. 
O prêmio tem como objetivo apoiar o avanço da engenharia química e o desenvolvimento de pesquisas que 
contribuam significativamente para o crescimento da ciência e tecnologia do país. Desde seu lançamento, o 
prêmio contemplou 28 mestres e doutores. Nesta edição, concorreram 56 trabalhos, sendo 39 dissertações de 
mestrado e 17 teses de doutorado. Todos buscaram soluções inovadoras dentro de temas variados, que podem 
contribuir para o desenvolvimento da indústria química no país. A premiação aconteceu no dia 27 de março em 
São Paulo. Em anos anteriores, outros alunos da FEQ já receberam o prêmio: Márcio Bezerra Machado (2005, 
primeiro lugar no doutorado); Cláudia Garcia Vasconcelos (2000, segundo lugar no mestrado); e César Benedito 
Batistella (2000, segundo lugar no doutorado). 
 
 
Página 12 Boletim da FEQ
 
Profa. Ângela lança livro sobre cultivo de células animais 
A Profa. Dra. Ângela Maria Moraes, do Departamento de Processos 
Biotecnológicos, é uma das autoras do livro "Animal Cell 
Technology: from Biopharmaceuticals to Gene Therapy", publicado 
pela editora Taylor & Francis (ISBN 978-0-415-42304-5). O livro, 
que tem como co-autores os professores Leda Castilho 
(COPPE/UFRJ), Elisabeth Augusto (IPT) e Michael Butler 
(Universidade de Manitoba, Canadá), enfoca variados aspectos do 
conhecimento fundamental e dos progressos alcançados nos 
últimos 20 anos na área de tecnologia de cultivo de células 
animais, principalmente de células de mamíferos e de insetos. 
Assuntos básicos como meios de cultura, metabolismo, 
crescimento e morte celular, clonagem e expressão de proteínas 
transgênicas são abordados, assim como aspectos tecnológicos 
envolvendo projeto, operação, monitoramento e controle de 
biorreatores, além de processos de separação dos bioprodutos. O 
lançamento do livro foi objeto de matéria no Jornal da Unicamp 
(393). 
 
Professores Felder e Brent ministram curso sobre técnicas eficientes de ensino 
 
 
Prof. Richard Felder Prof. Rebecca Brent 
A FEQ recebeu a visita de dois destacados educadores 
na área de Engenharia Química, os professores Richard 
Felder e Rebecca Brent, da North Carolina State 
University e da empresa Education Design, Inc., que 
ministraram o curso “Teaching Engineering Effectively”. 
O curso, que teve o apoio do programa Escola de Altos 
Estudos da CAPES, foi ministrado na UNICAMP e 
transmitido, por teleconferência, para os 
Departamentos de Engenharia Química da Poli/USP e da 
UFSCar; também foi transmitido, via Internet, para mais 
nove universidades. Os atuais e futuros professores 
(alunos de pós-graduação puderam também acompanhar 
o curso) que participaram se beneficiarão, sem dúvida, 
das técnicas aprendidas, o que deve se traduzir em uma 
maior qualidade do ensino. O curso foi organizado pela 
Profa. Dra. Liliane Lona, Coordenadora de Pós-
Graduação da FEQ. 
 
Purificação de proteínas usando eletrólitos voláteis 
A linha de pesquisa coordenada pelo Prof. Dr. Everson Alves 
Miranda, do Departamento de Processos Biotecnológicos, que 
estuda a purificação de proteínas por meio da sua precipitação 
usando o efeito “salting out” causado por eletrólitos voláteis, foi 
matéria do Jornal da Unicamp (390). As etapas de purificação de 
proteínas para uso farmacêutico podem responder por 70-80% do 
custo total do processo, de forma que qualquer melhora traz 
grandes benefícios econômicos. A linha de pesquisa foi 
inicialmente proposta pelo saudoso Prof. Dr. Rahoma S. Mohamed, 
em projeto conjunto com o Prof. Dr. Gerd Maurer, da 
Universidade Técnica de Kaiserslautern (Alemanha), e já deu 
origem a várias teses de mestrado e doutorado. Hoje o grupo 
conta com a colaboração do Prof. Dr. Pedro Pessoa Filho (USP) e os 
pesquisadores Alexandre Tashima, Érika Watanabe e Leonardo 
Lima. 
Prof. Everson Alves Miranda 
(Foto: Antoninho Perri, Jornal da Unicamp)