Aula 5 - Tecido Adiposo

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MOLECULAR BIOLOGY OF 
THE CELL GROUP 
Cancer Metabolism Division 
TIPOS DE TA 
• BRANCO 
(unilocular, 
amarelo). 
 
 
• MARROM 
(multilocular) 
TECIDO ADIPOSO BRANCO 
 
 
MES 
 (%) 
 
 RPAT 
 (%) 
 
 EAT 
 (%) 
 
 
 
 C 
 
 TB 
 
 C 
 
 TB 
 
 C 
 
 TB 
 
14:0 
 
2.03 + 0.45 
 
1.59 + 0.33 
 
2.37 + 0.24 
 
1.55 + 0.07 
 
1.99 + 0.21 
 
1.72 + 0.08 
 
16:0 
 
45.70+4.11 
 
39.99+ 3.3 
 
43.49+2.39 
 
43.00+10.6 
 
45.53+5.76 
 
41.35+8.77 
 
16:1 
 
_______ 
 
0.55+0.01* 
 
1.17 + 0.64 
 
0.76 + 0.81 
 
1.91 + 0.66 
 
3.82 + 1.24 
 
18:0 
 
10.11+0.65 
 
8.79+0.50* 
 
7.37 + 1.53 
 
2.68 + 2.57 
 
4.44 + 1.49 
 
1.00 + 0.74 
 
18:1 
 
16.81+2.54 
 
21.19+0.51 
 
18.38+0.80 
 
22.01+3.79 
 
19.63+2.85 
 
16.17+4.58 
 
18:2 
 
24.24+ 1.6 
 
27.20+3.27 
 
27.06+3.99 
 
37.67+4.68 
 
26.98+2.06 
 
36.27+2.0* 
 
sc 
M cel 
MES 
FEMURAL 
PERIGONADAL 
Belmonte et al., 2004 
Kuk et al., 2006 
Manipulação da dieta: efeitos 
heterogêneos 
TAG 
Rβ 
Adenil 
Ciclase 
Gs 
ATP AMPc 
R 
C C 
R 
PKA 
P 
P 
P P P P P 
P 
P 
-P 
-P -P 
-P 
-P 
-P 
-P 
CATECOLAMINAS 
TAG 
TAG 
TAG 
TAG 
TAG TAG 
P P 
P 
P P P P 
P 
R R 
ALBUMINA 
AG 
AG 
AG AG 
Diferenças no TA 
• Diidroepiandosterona (DHEAS) <om e 
sc 
• E e P >diferenciação ad. 
• Testosterona :reduz receptores L-2, > 
cpcdd lipolítica 
• HSL dep tamanho cel 
• Visc>SC>Glu -lipólise em homem 
• Dep omental e mesentérico > nos 
homens 
 
 
• Endócrino!!!! 
 
 
• Hormônios e citocinas= 
adipocinas 
Ronti et al., 2006 
Ronti et al., 2006 
 
Table 1. Factors produced by WAT 
 
Secreted proteins Receptors Enzymes and transporters 
Leptin Peptide and glycoprotein Lipid metabolism 
Adiponectin Insulin Lipoprotein lipase 
Resistin (in rodents) Glucagon Apolipoprotein E 
Angiotensinogen Thyroid stimulating hormone Cholesterol ester transfer protein 
TNF- Growth hormone Adipocyte fatty acid binding protein 
IL-6 Angiotensin-II CD36 
Adipsin Gastrin/cholecystokinin B 
Acylation stmulating protein Adiponectin Glucose metabolism 
Fasting-induced adipose factor Cytokine Insulin receptor substrate 1,2 
PAI-1 IL-6 Phosphatidylinositol 3-kinase 
Tissue factor TNF- Protein kinase B (Akt) 
Monocyte chemoattractant protein-1 Leptin GLUT4 
Tranforming growth factor-ß Protein kinase / 
Visfatin Nuclear 
Vaspin PPAR Glycogen synthase kinase-3 
Retinol binding protein-4 Glucocorticoid 
 Estrogen Steroid metabolism 
 Progesterone Aromatase 
 Androgen 11ß-hydroxysteroid dehydrogenase type 1 
 Thyroid 17ß-hydroxysteroid dehydrogenase 
 Vitamin D 
 Nuclear factor- B 
Outras ações leptina: 
Controle da composição corporal e apetite; 
 
Puberdade e reprodução; 
 
Resposta imune; 
 
Sensibilidade à insulina no músculo e fígado 
Adiponectina 
Heterogeneidade endócrina 
humanos 
• Resistina: abdominal>femural 
 
• IL6: omental> SC 
 
• Adiponectina: SC> visceral 
 
• Leptina: SC> visceral? 
 
• Visfatina: Visceral> SC 
 
• Teoria da síndrome X vs. 
Gordura visceral 
obesidade 
Bibliografia básica 
• A Halpern, AFG Matos, HL Matos, MC Mancini, 
MT Zanella. Obesidade. Lemos Ed. São 
Paulo,1998 
• T Brody. Nutritional Biochemistry.Academic 
Press, London, 1999 
• Ciba Foundation Symposium. The origins and 
consequences of obesityJohn Wiley & Sons, 
New York, 1996 
 
Institution: BRAZ 35042 MEDIC.RIB-80 Sign In as Member 
 
 
Table 2. ORs for all-cause mortality 
 
 
Model 1: control for age + follow-up time. Model 2: control for age, follow-up time, abdominal subcutaneous fat, visceral fat, and liver fat. 
OR, odds ratio; SE, standard error; CTL, liver attenuation; CTS, spleen attenuation. 
* The ORs for mortality in the table are expressed per SD for each variable. 
 Cubic transformation used in the analyses. 
 
 
 
 
 
 
 
 
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Model 1 Model 2 
ß SE OR (95% CI)* p ß SE OR (95% CI)* p 
Visceral fat mass (kg) 0.85 0.29 1.83 (1.23 to 
2.73) 
0.00
3 
0.86 0.41 1.81 (1.04 to 
3.14) 
0.04 
Subcutaneous fat mass (kg) 1.20 0.58 1.44 (1.02 to 
2.03) 
0.04 –0.02 0.78 0.99 (0.63 to 
1.58) 
0.98 
Visceral fat (L4–L5) (cm2) 5.0 x 10–8 1.9 x 10–8 1.76 (1.16 to 
2.67) 
0.00
8 
4.7 x 10–8 2.4 x 10–8 1.69 (0.99 to 
2.89) 
0.05 
Subcutaneous fat (L4–L5) (cm2) 0.003 0.002 1.31 (0.93 to 
1.85) 
0.15 –0.002 0.003 0.85 (0.53 to 
1.36) 
0.49 
Waist circumference (cm) 1.19 x 
10–6 
5.89 x 
10–7 
1.41 (1.01 to 
1.98) 
0.04 –1.7 x 
10–6 
1.53 x 
10–6 
0.60 (0.25 to 
1.44) 
0.26 
Mean liver (HU) –0.04 0.01 0.64 (0.46 to 
0.87) 
0.00
5 
–0.01 0.02 0.87 (0.56 to 
1.37) 
0.55 
CTL/CTS –1.37 0.82 0.76 (0.54 to 
1.05) 
0.10 1.13 1.69 1.26 (0.64 to 
2.48) 
0.50 
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