<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg1.png"><div class="t m0 x1 h1 y1 ff1 fs0 fc0 sc0 ls0 ws0">PRINC<span class="ff2 ls1">Í</span><span class="ls2 ws3">PIOS <span class="_0 blank"></span>DE <span class="_1 blank"></span>A<span class="_2 blank"> </span><span class="ff2 ls6 ws1">ÇÃ</span><span class="ls0">O </span></span></div><div class="t m0 x2 h1 y2 ff1 fs0 fc0 sc0 ls2 ws3">DOS <span class="_3 blank"></span>F<span class="_2 blank"></span><span class="ff2 ls3">Á</span>RMACOS <span class="_4 blank"></span>NOS <span class="_4 blank"></span></div><div class="t m0 x3 h1 y3 ff1 fs0 fc0 sc0 ls0 ws3">RECEPTORES <span class="_0 blank"></span>E NA </div><div class="t m0 x4 h1 y4 ff1 fs0 fc0 sc0 ls0 ws0">SINALIZA<span class="ff2 ls6 ws1">ÇÃ</span><span class="ws3">O </span></div><div class="t m0 x5 h1 y5 ff1 fs0 fc0 sc0 ls0 ws0">INTRACELULA<span class="_1 blank"></span>R<span class="ls7 ws3"> </span></div><div class="t m0 x6 h2 y6 ff1 fs1 fc0 sc0 ls4 ws3">Profa. <span class="_4 blank"></span>Dra. <span class="_3 blank"></span>Wanessa <span class="_5 blank"></span>Medina<span class="_2 blank"> </span> <span class="_6 blank"></span></div><div class="t m0 x7 h2 y7 ff1 fs1 fc1 sc0 ls5 ws2">gwanessa@fc<span class="_1 blank"></span>frp<span class="_1 blank"></span>.us<span class="_1 blank"></span>p.b<span class="_1 blank"></span>r<span class="fc0 ls7 ws3"> </span></div><div class="t m0 x8 h3 y8 ff1 fs2 fc0 sc0 ls7 ws3"> </div><a class="l"><div class="d m1" style="border-style:none;position:absolute;left:534.750000px;bottom:113.980000px;width:170.420000px;height:15.750000px;background-color:rgba(255,255,255,0.000001);"></div></a></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg2.png"><div class="t m0 x9 h4 y9 ff1 fs3 fc0 sc0 ls8 ws4">INTRODU<span class="ff2 ls15 ws5">ÇÃ</span><span class="ls7 ws3">O<span class="_7 blank"> </span> </span></div><div class="t m0 xa h5 ya ff1 fs4 fc2 sc0 ls9 ws3"> <span class="ls16 ws6">Na</span><span class="lsa"> <span class="ls16 ws6">farmacodin<span class="ff2 ls7 ws7">â</span>mica,</span><span class="ls7"> <span class="_8 blank"> </span>a <span class="_8 blank"> </span><span class="ls16 ws6">maioria</span><span class="lsb"> <span class="ls16 ws6">das</span><span class="lsc"> <span class="ls16 ws6">drogas<span class="_1 blank"></span><span class="lsc ws3"> <span class="ls16 ws6">precisa<span class="_1 blank"></span><span class="ls7 ws3"> </span></span></span></span></span></span></span></span></div><div class="t m0 xb h6 yb ff1 fs5 fc2 sc0 ls17 ws6">ligar<span class="ls7 ws8">-</span>se<span class="ls7 ws3"> <span class="_9 blank"> </span>a <span class="_9 blank"> </span></span>um<span class="lsd ws3"> </span>receptor<span class="lse ws3"> </span>para<span class="lsf ws3"> </span>produzir<span class="lsd ws3"> </span>algum<span class="lsf ws3"> </span>efeito<span class="_a blank"> </span><span class="ls7 ws3">. </span></div><div class="t m0 xb h5 yc ff1 fs4 fc2 sc0 ls16 ws6">Entretanto<span class="ls10 ws3"> </span>ao<span class="ls7 ws3"> <span class="_b blank"> </span>n<span class="ff2 ws7">í</span></span>vel<span class="ls10 ws3"> </span>molecular,<span class="ls7 ws3"> <span class="_b blank"> </span>a <span class="_c blank"> </span></span>liga<span class="ff2 ls18 ws9">çã</span><span class="ls7 ws3">o <span class="_c blank"> </span></span>da<span class="ls10 ws3"> </span>droga<span class="_a blank"> </span><span class="ls7 ws3"> </span></div><div class="t m0 xb h5 yd ff1 fs4 fc2 sc0 ls16 ws6">representa<span class="ls11 ws3"> </span>apenas<span class="ls7 ws3"> <span class="_d blank"> </span>a <span class="_d blank"> </span></span><span class="wsa">primeira <span class="ls11 ws3"> </span></span>de<span class="ls12 ws3"> </span>uma<span class="ls11 ws3"> </span><span class="wsa">sequencia <span class="ls7 ws3"> </span></span></div><div class="t m0 xb h5 ye ff1 fs4 fc2 sc0 ls16 ws6">complexa<span class="ls7 ws3"> <span class="_1 blank"></span><span class="ls16 ws6">de<span class="ls13 ws3"> </span>etapas<span class="ls7 ws3">. </span></span></span></div><div class="t m0 xa h5 yf ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div><div class="t m0 xa h7 y10 ff1 fs5 fc2 sc1 ls14 ws3"> <span class="_f blank"> </span>Tipos<span class="_1 blank"></span> <span class="_0 blank"></span>de <span class="_4 blank"></span>Intera<span class="ff3 sc0 ls19 wsb">çõ</span><span class="ls7">e<span class="_2 blank"> </span>s <span class="_10 blank"></span>D<span class="_2 blank"> </span>r<span class="_2 blank"> </span>o<span class="_11 blank"> </span>g<span class="_2 blank"> </span>a<span class="_11 blank"> </span>-Re<span class="_2 blank"> </span>ceptor<span class="_2 blank"> </span> <span class="_12 blank"></span><span class="sc0 ls17">(agonistas </span></span></div><div class="t m0 xb h5 y11 ff1 fs4 fc2 sc0 ls16 ws3">diretos, <span class="_1 blank"></span>mol<span class="ff2 ls7 ws7">é</span>cula de acoplamento + mol<span class="_a blank"> </span><span class="ff2 ls7 ws7">é</span>cula efetora, </div><div class="t m0 xb h5 y12 ff1 fs4 fc2 sc0 ls16 ws3">antagonistas <span class="_1 blank"></span>diretos)<span class="ls7"> </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg3.png"><div class="t m0 x9 h4 y9 ff1 fs3 fc0 sc0 ls8 ws4">INTRODU<span class="ff2 ls15 ws5">ÇÃ</span><span class="ls7 ws3">O<span class="_7 blank"> </span> </span></div><div class="t m0 xa h8 y13 ff1 fs4 fc2 sc1 ls1a ws3"> <span class="_f blank"> </span>Agoni<span class="_1 blank"></span>s<span class="_1 blank"></span>t<span class="_1 blank"></span>a<span class="_1 blank"></span>s<span class="_1 blank"></span> <span class="_10 blank"></span>que <span class="_10 blank"></span>inibem<span class="_1 blank"></span>,<span class="_1 blank"></span> <span class="_10 blank"></span>Suas <span class="_0 blank"></span>Mol<span class="_2 blank"> </span><span class="ff3 sc0 ls7 wsc">é</span>cula<span class="_1 blank"></span>s<span class="_1 blank"></span> <span class="_0 blank"></span>de <span class="_13 blank"></span>Liga<span class="_a blank"> </span><span class="ff3 sc0 ls18 wsd">çõ</span><span class="ls7">e<span class="_2 blank"> </span>s <span class="_10 blank"></span>e<span class="_11 blank"> </span> </span></div><div class="t m0 xb h5 y14 ff1 fs4 fc2 sc1 ls7 ws3">A<span class="_2 blank"> </span>g<span class="_11 blank"> </span>o<span class="_2 blank"> </span>n<span class="_2 blank"> </span>istas <span class="_5 blank"></span>P<span class="_2 blank"> </span>a<span class="_2 blank"> </span>r<span class="_11 blank"> </span>c<span class="_2 blank"> </span>ia<span class="_11 blank"> </span>is <span class="_12 blank"></span><span class="sc0 ls16">(agonistas integrais x agonistas </span></div><div class="t m0 xb h5 y15 ff1 fs4 fc2 sc0 ls16 ws6">end<span class="ff2 ls7 ws7">ó<span class="ff1 ws3">genos, <span class="_14 blank"></span> agonistas parciais x ag<span class="_6 blank"></span>onistas </span></span></div><div class="t m0 xb h5 y16 ff1 fs4 fc2 sc0 ls16 ws6">integrais)<span class="sc1 ls7 ws3"> </span></div><div class="t m0 xa h8 y17 ff1 fs4 fc2 sc1 ls9 ws3"> <span class="ls1b wse">Dura<span class="ff3 sc0 ls18 wsd">çã</span></span><span class="ls7">o <span class="_10 blank"></span>d<span class="_2 blank"> </span>e<span class="_11 blank"> </span> <span class="_14 blank"></span>A<span class="_11 blank"> </span><span class="ff3 sc0 ls18 wsd">çã</span><span class="ls1a">o <span class="_3 blank"></span>das <span class="_12 blank"></span>Drogas<span class="_14 blank"></span> <span class="_10 blank"></span><span class="sc0 ls16 ws6">(liga<span class="ff2 ls18 ws9">çã</span><span class="ls7 ws3">o <span class="_a blank"> </span>droga <span class="_a blank"> </span><span class="ff4">\u2013</span></span></span></span></span></div><div class="t m0 xb h5 y18 ff1 fs4 fc2 sc0 ls16 ws3">receptor <span class="_14 blank"></span>efetor , liga<span class="_a blank"> </span><span class="ff2 ls18 ws9">çõ</span>es covalentes e </div><div class="t m0 xb h5 y19 ff1 fs4 fc2 sc0 ls16 ws6">dessensibiliza<span class="ff2 ls18 ws9">çã</span>o)<span class="sc1 ls7 ws3"> </span></div><div class="t m0 xa h8 y1a ff1 fs4 fc2 sc1 ls7 ws3"> <span class="_e blank"> </span>R<span class="_2 blank"> </span>e<span class="_11 blank"> </span>c<span class="_2 blank"> </span>e<span class="_2 blank"> </span>ptores<span class="_2 blank"> </span> <span class="_12 blank"></span>e<span class="_2 blank"> </span> <span class="_14 blank"></span>S<span class="_7 blank"> </span><span class="ff3 sc0 wsc">í</span><span class="ls1a">tios <span class="_0 blank"></span>de <span class="_13 blank"></span>Liga<span class="_a blank"> </span><span class="ff3 sc0 ls18 wsd">çã</span>o <span class="_0 blank"></span>Inerte<span class="_1 blank"></span>s<span class="_1 blank"></span> <span class="_0 blank"></span><span class="sc0 ls1c"> <span class="ls16">( albumina </span></span></span></div><div class="t m0 xb h5 y1b ff1 fs4 fc2 sc0 ls16 ws6">plasm<span class="ff2 ls7 ws7">á<span class="ff1 ws3">tica <span class="_14 blank"></span>sem efeito biol<span class="ff2 ws7">ó</span><span class="ls16 ws6">gico)</span><span class="sc1"> </span></span></span></div><div class="t m0 xa h5 y1c ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg4.png"><div class="t m0 xc h4 y1d ff1 fs3 fc0 sc0 ls8 ws3">RECEPTORES <span class="_0 blank"></span>DE <span class="_14 blank"></span>F<span class="ff2 ls1d">Á</span>RMACOS <span class="_3 blank"></span><span class="ls7"> </span></div><div class="t m0 xd h5 y1e ff1 fs4 fc2 sc0 ls9 ws3"> <span class="ls16">Efeitos <span class="_14 blank"></span>terap<span class="_a blank"> </span><span class="ff2 ls7 ws7">ê</span>uticos X intera<span class="ff2 ls18 ws9">çõ</span>es com mol<span class="_a blank"> </span><span class="ff2 ls7 ws7">é</span><span class="ws6">culas</span><span class="ls7"> </span></span></div><div class="t m0 xd h6 y1f ff1 fs5 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div><div class="t m0 xe h5 y20 ff5 fs4 fc3 sc0 ls1e">\uf0ad<span class="ff1 fc2 ls16 ws6">Macromol<span class="ff2 ls7 ws7">é</span><span class="ws3">cula <span class="_14 blank"></span><span class="ff4 ls7 wsf">\u2192<span class="ff1 ls13 ws3"> <span class="ls16">atividade biof</span></span><span class="ff2 ws7">í<span class="ff1 ls16 ws3">sica ou </span></span></span></span></span></div><div class="t m0 x1 h5 y21 ff1 fs4 fc2 sc0 ls16 ws6">bioqu<span class="ff2 ls7 ws7">í</span>mica<span class="ls7 ws3"> </span></div><div class="t m0 xe h6 y22 ff1 fs5 fc2 sc1 ls7 ws3"> </div><div class="t m0 xe h5 y23 ff1 fs4 fc2 sc1 ls7 ws10">R E C E PTOR:<span class="sc0 ws3"> <span class="_10 blank"></span><span class="ls16">Componente de uma c<span class="_a blank"> </span><span class="ff2 ls7 ws7">é</span><span class="ls7">lula <span class="_2 blank"> </span>ou organismo </span></span></span></div><div class="t m0 xe h5 y24 ff1 fs4 fc2 sc0 ls7 ws3">que <span class="_14 blank"></span>interage com uma droga e d<span class="ff2 ws7">á</span><span class="ls1c"> <span class="ls16 ws6">in</span></span><span class="ff2 ws7">í</span><span class="ls16">cio </span><span class="ff2 ws7">à</span><span class="ls1c"> <span class="ls16">cadeia </span></span></div><div class="t m0 xe h5 y25 ff1 fs4 fc2 sc0 ls7 ws3">de <span class="_14 blank"></span>eventos bioqu<span class="ff2 ws7">í</span><span class="ls16">micos que levam aos efeitos </span></div><div class="t m0 xe h6 y26 ff1 fs5 fc2 sc0 ls17 ws3">observados <span class="_14 blank"></span>do f<span class="_a blank"> </span><span class="ff2 ls7 ws11">á</span><span class="ws6">rmaco.</span><span class="sc1 ls7"> </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg5.png"><div class="t m0 xc h4 y1d ff1 fs3 fc0 sc0 ls8 ws3">RECEPTORES <span class="_0 blank"></span>DE <span class="_14 blank"></span>F<span class="ff2 ls1d">Á</span>RMACOS <span class="_3 blank"></span><span class="ls7"> </span></div><div class="t m0 xd h5 y27 ff1 fs4 fc2 sc1 ls1a ws3"> <span class="_f blank"> </span>Paul <span class="_0 blank"></span>Ehrlic<span class="_14 blank"></span>h<span class="_6 blank"></span><span class="sc0 ls7">= <span class="_10 blank"></span>certos agentes <span class="ls16 ws6">org</span><span class="ff2 ws7">â</span><span class="ls16">nicos sint</span><span class="ff2 ws7">é</span><span class="ls16">ticos </span></span></div><div class="t m0 xf h5 y28 ff1 fs4 fc2 sc0 ls16 ws3">exerciam <span class="_14 blank"></span>efeitos <span class="_a blank"> </span>antiparasit<span class="_a blank"> </span><span class="ff2 ls7 ws7">á</span>rios caracter<span class="ff2 ls7 ws7">í</span>sticos , </div><div class="t m0 xf h6 y29 ff1 fs5 fc2 sc0 ls17 ws3">enquanto <span class="_14 blank"></span>outros n<span class="_a blank"> </span><span class="ff2 ls7 ws11">ã</span>o tinham efeito.<span class="ls7"> </span></div><div class="t m0 xd h5 y2a ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div><div class="t m0 xd h5 y2b ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span>Os <span class="_14 blank"></span>receptores: al<span class="ff2 ws7">é</span><span class="ls16">m da utilidade para <span class="_a blank"> </span>explicar a </span></div><div class="t m0 xf h6 y2c ff1 fs5 fc2 sc0 ls17 ws6">biologia<span class="ls7 ws3">, <span class="_1 blank"></span>possui impor<span class="_6 blank"></span>tantes consequ<span class="ff2 ws11">ê</span><span class="ls17">ncias pr</span><span class="ff2 ws11">á</span><span class="ls17">ticas </span></span></div><div class="t m0 xf h5 y2d ff1 fs4 fc2 sc0 ls7 ws3">para <span class="_14 blank"></span>o <span class="ls16">desenvolvimento de f<span class="_a blank"> </span></span><span class="ff2 ws7">á</span><span class="ls16 ws6">rmacos</span> <span class="ls16">e para a tomada </span></div><div class="t m0 xf h5 y2e ff1 fs4 fc2 sc0 ls7 ws3">de <span class="_14 blank"></span>decis<span class="ff2 ws7">õ</span><span class="ls16">es terap</span><span class="ff2 ws7">ê</span><span class="ls16">uticas na pr</span><span class="ff2 ws7">á</span><span class="ls16">tica cl</span><span class="ff2 ws7">í</span>nica. <span class="_2 blank"> </span> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg6.png"><div class="t m0 xc h4 y1d ff1 fs3 fc0 sc0 ls8 ws3">RECEPTORES <span class="_0 blank"></span>DE <span class="_14 blank"></span>F<span class="ff2 ls1d">Á</span>RMACOS <span class="_3 blank"></span><span class="ls7"> </span></div><div class="t m0 x10 h5 y2f ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div><div class="t m0 x10 h5 y30 ff1 fs4 fc2 sc0 ls9 ws3"> <span class="ls1f">Determinam <span class="_14 blank"></span>, em grande parte, as rela<span class="_6 blank"></span><span class="ff2 ls21 ws12">çõ<span class="ff1 ls1f ws3">es </span></span></span></div><div class="t m0 x11 h5 y31 ff1 fs4 fc2 sc0 ls1f ws3">quantitativas <span class="_14 blank"></span>entre a dose ou concentra<span class="_6 blank"></span><span class="ff2 ls21 ws12">çã<span class="ff1 ls1f ws3">o do </span></span></div><div class="t m0 x11 h5 y32 ff1 fs4 fc2 sc0 ls1f">f<span class="ff2 ls7 ws7">á</span><span class="ls7 ws3">rmaco <span class="_14 blank"></span>e seus <span class="ls1f">efeitos farmacol</span><span class="ff2 ws7">ó<span class="_6 blank"></span><span class="ff1 ls1f ws8">gicos<span class="ls7 ws3"> </span></span></span></span></div><div class="t m0 x12 h8 y33 ff5 fs4 fc3 sc0 ls1e">\uf0ad<span class="ff1 fc4 sc2 ls7 ws3">A<span class="_2 blank"> </span>F<span class="_11 blank"> </span>I<span class="_2 blank"> </span>N<span class="_11 blank"> </span>IDADE <span class="_4 blank"></span> <span class="_11 blank"> </span>X<span class="_2 blank"> </span> <span class="_3 blank"></span> <span class="_11 blank"> </span>C<span class="_2 blank"> </span>O<span class="_11 blank"> </span>N<span class="_2 blank"> </span>C<span class="_11 blank"> </span>ENTR<span class="_2 blank"> </span>A<span class="ff3 sc0 ls21 ws13">ÇÃ</span><span class="ls20">O<span class="_1 blank"></span> <span class="_0 blank"></span>NECESS<span class="_14 blank"></span><span class="ff3 sc0 ls7 wsc">Á<span class="ff1 sc2 ws3">R<span class="_2 blank"> </span>IA <span class="_12 blank"></span> <span class="_2 blank"> </span><span class="fc2 sc0 ls1f">= </span></span></span></span></span></div><div class="t m0 x13 h6 y34 ff1 fs5 fc2 sc0 ls7 ws3">complexos <span class="_14 blank"></span> </div><div class="t m0 x12 h5 y35 ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_15 blank"> </span> <span class="_16 blank"> </span> <span class="_16 blank"> </span> <span class="_16 blank"> </span> <span class="_16 blank"> </span> <span class="_14 blank"></span> <span class="_a blank"> </span> f<span class="ff2 ws7">á</span><span class="ls1f ws8">rmaco<span class="_6 blank"></span><span class="ls7">-</span></span></div><div class="t m0 x12 h6 y36 ff1 fs5 fc2 sc0 ls7 ws3">receptor </div><div class="t m0 x12 h5 y37 ff5 fs4 fc3 sc0 ls1e">\uf0ad<span class="ff1 fc2 ls7 ws3">Numero <span class="_1 blank"></span>total de <span class="fc4 ls1f ws8">receptores</span><span class="ls1f"> pode limitar o <span class="_6 blank"></span><span class="fc4">efeito </span></span></span></div><div class="t m0 x13 h6 y38 ff1 fs5 fc4 sc0 ls7 ws8">m<span class="ff2 ws11">á</span>ximo<span class="fc2 ws3"> <span class="_14 blank"></span>produzido pelo f<span class="ff2 ws11">á<span class="_6 blank"></span><span class="ff1 ws3">rmaco </span></span></span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg7.png"><div class="t m0 xc h4 y1d ff1 fs3 fc0 sc0 ls8 ws3">RECEPTORES <span class="_0 blank"></span>DE <span class="_14 blank"></span>F<span class="ff2 ls1d">Á</span>RMACOS <span class="_3 blank"></span><span class="ls7"> </span></div><div class="t m0 x14 h5 y39 ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span>Os <span class="_14 blank"></span>receptores s<span class="ff2 ws7">ã</span><span class="ls16">o respons</span><span class="ff2 ws7">á</span><span class="ls16">veis pela <span class="fc4">seletividade da </span></span></div><div class="t m0 x15 h6 y3a ff1 fs5 fc4 sc0 ls7 ws8">a<span class="ff2 ls19 ws9">çã</span><span class="ws3">o <span class="_14 blank"></span>dos f<span class="ff2 ws11">á</span><span class="ls17 ws6">rmacos</span> </span></div><div class="t m0 x16 h5 y3b ff5 fs4 fc5 sc0 ls22">\uf0ad<span class="ff1 fc2 ls16 ws3">Tamanho <span class="_14 blank"></span>molecular<span class="_a blank"> </span><span class="ls7"> </span></span></div><div class="t m0 x16 h5 y3c ff5 fs4 fc5 sc0 ls22">\uf0ad<span class="ff1 fc2 ls16 ws6">Forma<span class="ls7 ws3"> </span></span></div><div class="t m0 x16 h5 y3d ff5 fs4 fc5 sc0 ls22">\uf0ad<span class="ff1 fc2 ls7 ws3">Carga <span class="_14 blank"></span>el<span class="ff2 ws7">é</span><span class="ls16 ws6">trica</span> </span></div><div class="t m0 x17 h6 y3e ff1 fs5 fc2 sc0 ls7 ws3"> </div><div class="t m0 x17 h5 y3f ff1 fs4 fc2 sc0 ls16 ws6">Altera<span class="ff2 ls18 ws9">çõ</span><span class="ls7 ws3">es <span class="_1 blank"></span>na <span class="ls16">estrutura qu</span><span class="ff2 ws7">í</span><span class="ls16">mica de um f</span><span class="ff2 ws7">á</span><span class="ls16">rmaco </span></span></div><div class="t m0 x17 h6 y40 ff1 fs5 fc2 sc0 ls17 ws3">pode <span class="_1 blank"></span>aumentar ou diminuir as afinidades <span class="_a blank"> </span>de um </div><div class="t m0 x17 h5 y41 ff1 fs4 fc2 sc0 ls7 ws3">novo <span class="_14 blank"></span>f<span class="ff2 ws7">á</span><span class="ls16">rmaco por diferentes classes de </span></div><div class="t m0 x17 h8 y42 ff1 fs4 fc2 sc0 ls16 ws3">receptores= <span class="_1 blank"></span><span class="fc4 sc2 ls1b wse">altera<span class="_1 blank"></span><span class="ff3 sc0 ls18 wsd">çõ<span class="ff1 sc2 ls1a ws3">e<span class="_1 blank"></span>s <span class="_0 blank"></span>nos <span class="_10 blank"></span>efeito<span class="_1 blank"></span>s <span class="_1 blank"></span></span></span></span></div><div class="t m0 x17 h8 y43 ff1 fs4 fc4 sc2 ls1b wse">terap<span class="_1 blank"></span><span class="ff3 sc0 ls7 wsc">ê<span class="ff1 sc2 ws3">utic<span class="_2 blank"> </span>os <span class="_10 blank"></span>e<span class="_2 blank"> </span> <span class="_1 blank"></span>t<span class="_11 blank"> </span><span class="ff3 sc0 wsc">ó</span><span class="ls1b wse">xicos</span> </span></span></div><div class="t m0 x18 h5 y44 ff1 fs4 fc2 sc0 ls7 ws3"> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg8.png"><div class="t m0 xc h4 y1d ff1 fs3 fc0 sc0 ls8 ws3">RECEPTORES <span class="_0 blank"></span>DE <span class="_14 blank"></span>F<span class="ff2 ls1d">Á</span>RMACOS <span class="_3 blank"></span><span class="ls7"> </span></div><div class="t m0 xa h8 y1e ff1 fs4 fc2 sc1 ls1a ws3"> <span class="_f blank"> </span>Os <span class="_10 blank"></span>recept<span class="_1 blank"></span>or<span class="_1 blank"></span>e<span class="_1 blank"></span>s<span class="_14 blank"></span> <span class="_0 blank"></span>medeia<span class="_1 blank"></span>m<span class="_1 blank"></span> <span class="_10 blank"></span>as <span class="_5 blank"></span>a<span class="_2 blank"> </span><span class="ff3 sc0 ls18 wsd">çõ</span><span class="ls7">e<span class="_2 blank"> </span>s<span class="_11 blank"> </span> <span class="_13 blank"></span>d<span class="_11 blank"> </span>e<span class="_2 blank"> </span> <span class="_1 blank"></span>a<span class="_2 blank"> </span>n<span class="_11 blank"> </span>t<span class="_2 blank"> </span>a<span class="_11 blank"> </span>go<span class="_2 blank"> </span>nistas<span class="_2 blank"> </span> </span></div><div class="t m0 xb h7 y45 ff1 fs5 fc2 sc1 ls7 ws14">f a r m acol<span class="ff3 sc0 ws15">ó</span><span class="ws3">g<span class="_2 blank"> </span>icos </span></div><div class="t m0 xa h5 y20 ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_e blank"> </span> </div><div class="t m0 x19 h5 y46 ff1 fs4 fc2 sc0 ls7 ws16">F<span class="ff2 ws7">á</span><span class="ws3">rmacos <span class="_14 blank"></span>e sinais qu<span class="ff2 ws7">í</span><span class="ls16">micos end</span><span class="ff2 ws7">ó</span><span class="ls16">genos </span><span class="ff4 wsf">\u2192</span><span class="ls1b"> <span class="_14 blank"></span><span class="ls16">regulam a </span></span></span></div><div class="t m0 x19 h5 y47 ff1 fs4 fc2 sc0 ls16 ws6">fun<span class="ff2 ls18 ws9">çã</span><span class="ls7 ws3">o <span class="_1 blank"></span>de macromol<span class="ff2 ws7">é</span><span class="ls16">culas receptoras como </span><span class="sc1">A<span class="_11 blank"> </span>G<span class="_2 blank"> </span>O<span class="_2 blank"> </span>N<span class="_11 blank"> </span>I<span class="_2 blank"> </span>ST<span class="_11 blank"> </span>AS </span></span></div><div class="t m0 x19 h6 y48 ff1 fs5 fc2 sc1 ls7 ws3"> </div><div class="t m0 x19 h5 y49 ff1 fs4 fc2 sc1 ls7 ws3"> </div><div class="t m0 xa h5 y4a ff1 fs4 fc2 sc1 ls7 ws3"> <span class="_e blank"> </span>A<span class="_2 blank"> </span>G<span class="_11 blank"> </span>O<span class="_2 blank"> </span>N<span class="_2 blank"> </span>ISTAS<span class="_a blank"> </span> </div><div class="t m0 x19 h5 y4b ff1 fs4 fc2 sc1 ls7 ws3"> </div><div class="t m0 xa h5 y4c ff1 fs4 fc2 sc1 ls7 ws3"> <span class="_e blank"> </span>A<span class="_2 blank"> </span>N<span class="_11 blank"> </span>T<span class="_2 blank"> </span>A<span class="_2 blank"> </span>GONIST<span class="_2 blank"> </span>AS <span class="_12 blank"></span> </div><div class="t m0 x19 h5 y4d ff1 fs4 fc2 sc0 ls7 ws3">( <span class="_14 blank"></span>a<span class="ff2 ls18 ws9">çã</span><span class="ls16">o de alguns dos f<span class="_a blank"> </span></span><span class="ff2 ws7">á</span><span class="ls16">rmacos mais </span> </div><div class="t m0 x19 h5 y4e ff1 fs4 fc2 sc0 ls7 ws3"> <span class="_14 blank"></span><span class="ls16"> <span class="ff2 ls7 ws7">ú</span>teis na clinica m<span class="_a blank"> </span><span class="ff2 ls7 ws7">é</span>dica )<span class="ls7"> </span></span></div><div class="t m0 x1a h5 y4f ff1 fs4 fc2 sc0 ls7 ws3"> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bg9.png"><div class="t m0 x1b h9 y50 ff1 fs6 fc0 sc0 ls8 ws3">NATUREZA <span class="_14 blank"></span>MACROMOLECULAR </div><div class="t m0 x1c h9 y51 ff1 fs6 fc0 sc0 ls23 ws3">DOS <span class="_14 blank"></span>RECEPTORES DE DROGAS<span class="_7 blank"> </span> <span class="_14 blank"></span></div><div class="t m0 x1d h7 y52 ff1 fs5 fc2 sc0 ls17 ws6">Os<span class="ls24 ws3"> <span class="sc1 ls7 ws14">rece ptores </span><span class="ls7"> <span class="_17 blank"> </span>, <span class="_17 blank"> </span></span></span>em<span class="ls25 ws3"> </span>sua<span class="_1 blank"></span><span class="ls26 ws3"> <span class="ls17 ws6">maioria,</span><span class="ls7"> <span class="_17 blank"> </span>s<span class="ff2 ws11">ã</span>o <span class="_c blank"> </span><span class="sc1 ws17">pro te </span><span class="ff3 ws15">í<span class="_1 blank"></span><span class="ff1 sc1 ls17 ws18">nas <span class="sc0 ls7 ws3">, </span></span></span></span></span></div><div class="t m0 x1d h5 y53 ff1 fs4 fc2 sc0 ls16 ws6">presumivelmente<span class="ls27 ws3"> </span>porque<span class="_a blank"> </span><span class="ls27 ws3"> </span>as<span class="ls28 ws3"> <span class="sc1 ls7">e<span class="_2 blank"> </span>st<span class="_2 blank"> </span>rutura<span class="_11 blank"> </span>s <span class="_18 blank"> </span><span class="ls16 ws19">dos </span> </span></span></div><div class="t m0 x1d h8 y54 ff1 fs4 fc2 sc1 ls7 ws1a">pol ipept <span class="ff3 sc0 wsc">í</span><span class="ls16 ws6">dios<span class="ls29 ws3"> </span><span class="sc0">proporcionam<span class="ls2a ws3"> </span>tanto<span class="ls7 ws3"> <span class="_19 blank"> </span>a <span class="_1a blank"> </span></span></span></span><span class="ws1b">diver sidade <span class="sc0 ws3"> </span></span></div><div class="t m0 x1d h5 y55 ff1 fs4 fc2 sc0 ls16 ws6">quanto<span class="ls7 ws3"> <span class="_1b blank"> </span>a <span class="_1b blank"> </span><span class="sc1 ws1c">e spec ificid ade<span class="_11 blank"> </span></span><span class="ls2b"> </span></span>necess<span class="ff2 ls7 ws7">á</span>rias<span class="ls2b ws3"> </span>em<span class="ls2c ws3"> </span>termos<span class="ls2c ws3"> </span><span class="ws1d">de <span class="ls7 ws3"> </span></span></div><div class="t m0 x1d h5 y56 ff1 fs4 fc2 sc0 ls16 ws6">forma<span class="ls7 ws3"> <span class="_1 blank"></span>e <span class="ls16 ws6">carga</span><span class="ls13"> <span class="ls16 ws6">el</span></span><span class="ff2 ws7">é</span><span class="ls16 ws6">trica</span>. </span></div><div class="t m0 x1d h7 y57 ff5 fs5 fc5 sc0 ls2d">\uf0ad<span class="ff1 fc2 sc1 ls7 ws17">PRO TE <span class="ff3 sc0 ws15">Í<span class="_14 blank"></span><span class="ff1 sc1 ls17 ws1d">NAS <span class="ls7 ws3"> <span class="_1c blank"> </span>REGUL<span class="_2 blank"> </span>ADORAS<span class="_2 blank"> </span><span class="sc0">= <span class="_1c blank"> </span><span class="fc4 ls17 ws6">medeiam<span class="ls2e ws3"> </span>as</span><span class="fc4"> <span class="_1c blank"> </span>a<span class="ff2 ls19 ws9">çõ</span><span class="ls17 ws6">es</span><span class="ls2e"> <span class="ls17 ws6">de</span></span> </span></span></span></span></span></span></div><div class="t m0 xe h5 y58 ff1 fs4 fc4 sc0 ls16 ws6">sinais<span class="ls2f ws3"> </span>qu<span class="ff2 ls7 ws7">í</span>micos<span class="ls30 ws3"> </span>end<span class="ff2 ls7 ws7">ó</span>genos<span class="ls2f ws3"> <span class="fc2 ls7">( <span class="_1d blank"> </span><span class="ls16 ws1e">neurotransmissores,</span> </span></span></div><div class="t m0 xe h6 y59 ff1 fs5 fc2 sc0 ls17 ws6">autac<span class="ff2 ls7 ws11">ó</span>ides<span class="ls7 ws3"> <span class="_14 blank"></span>e <span class="ls17 ws6">hormonios</span>) </span></div><div class="t m0 x1d ha y5a ff1 fs7 fc2 sc0 ls7 ws3"> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/36dc1fb6-c866-43cf-801e-ff0c7ecab4a3/bga.png"><div class="t m0 x1e h9 y5b ff1 fs6 fc0 sc0 ls31 ws1f">RELA<span class="ff2 ls32">ÇÃ</span><span class="ws3">O ENTRE CONCENTRA<span class="_a blank"> </span><span class="ff2 ls32">ÇÃ</span>O DA </span></div><div class="t m0 x1f h9 y5c ff1 fs6 fc0 sc0 ls23 ws3">DROGA <span class="_14 blank"></span>&RESPOSTA<span class="_11 blank"> </span> <span class="_14 blank"></span></div><div class="t m0 x20 hb y5d ff1 fs8 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span>C<span class="_a blank"> </span>u<span class="_6 blank"></span>r<span class="_6 blank"></span>v<span class="_a blank"> </span>a<span class="_6 blank"></span>s<span class="_a blank"> </span> <span class="_1e blank"> </span>hipe<span class="_1 blank"></span>r<span class="_a blank"> </span>b<span class="_2 blank"> </span><span class="ff2 ws20">ó<span class="_14 blank"></span><span class="ff1 ws3">l<span class="_6 blank"></span>i<span class="_a blank"> </span>c<span class="_6 blank"></span>a<span class="_a blank"> </span> <span class="_1e blank"> </span><span class="ls35 ws21">de </span> <span class="_1e blank"> </span>Con<span class="_6 blank"></span>c<span class="_6 blank"></span>e<span class="_a blank"> </span>n<span class="_6 blank"></span>t<span class="_6 blank"></span>r<span class="_a blank"> </span>a<span class="_2 blank"> </span><span class="ff2 ls19 ws6">çã<span class="_1 blank"></span><span class="ff1 ls7 ws3">o<span class="_6 blank"></span>-<span class="_a blank"> </span>E<span class="_6 blank"></span>f<span class="_6 blank"></span>e<span class="_a blank"> </span>i<span class="_6 blank"></span>t<span class="_6 blank"></span>o<span class="_a blank"> </span> <span class="_1f blank"> </span>&<span class="_a blank"> </span> <span class="_1e blank"> </span>L<span class="_a blank"> </span>i<span class="_6 blank"></span>g<span class="_6 blank"></span>a<span class="_a blank"> </span><span class="ff2 ls19 ws6">çã</span>o <span class="_20 blank"> </span><span class="ls35 ws22">de</span> </span></span></span></span></div><div class="t m0 x21 hc y5e ff1 fs9 fc2 sc0 ls33 ws3">agonis<span class="_14 blank"></span>t<span class="_1 blank"></span>as<span class="_6 blank"></span> <span class="_0 blank"></span><span class="ls5 ws23">aos<span class="ls33 ws3"> <span class="_3 blank"></span>Recepto<span class="_14 blank"></span>r<span class="_1 blank"></span>es<span class="_6 blank"></span> <span class="_6 blank"></span></span></span></div><div class="t m0 x20 hc y5f ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y60 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y61 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y62 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y63 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y64 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y65 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y66 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span> </div><div class="t m0 x20 hc y67 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span>A<span class="_a blank"> </span>:<span class="_a blank"> </span> <span class="_13 blank"></span><span class="ls5 ws23">droga<span class="ls7 ws3"> <span class="_12 blank"></span><span class="ls5 ws23">ligada<span class="ls7 ws3"> <span class="_10 blank"></span><span class="ls5 ws23">ao<span class="ls7 ws3"> <span class="_3 blank"></span><span class="ls5 ws23">receptor<span class="_1 blank"></span><span class="ls7 ws3"> </span></span></span></span></span></span></span></span></div><div class="t m0 x20 hc y68 ff1 fs9 fc2 sc0 ls7 ws3"> <span class="_1e blank"> </span>B<span class="_a blank"> </span>:<span class="_6 blank"></span> <span class="_21 blank"> </span>c<span class="_a blank"> </span>o<span class="_6 blank"></span>n<span class="_6 blank"></span>c<span class="_a blank"> </span>e<span class="_6 blank"></span>n<span class="_6 blank"></span>t<span class="_a blank"> </span>ra<span class="_a blank"> </span><span class="ff2 ls18 ws6">çõ<span class="_14 blank"></span><span class="ff1 ls5 ws23">es<span class="_1 blank"></span><span class="ls34 ws3"> <span class="ls5 ws23">da<span class="_1 blank"></span><span class="ls7 ws3"> <span class="_21 blank"> </span>d<span class="_a blank"> </span>r<span class="_6 blank"></span>o<span class="_6 blank"></span>g<span class="_a blank"> </span>a <span class="_22 blank"> </span><span class="ls5 ws23">em<span class="_14 blank"></span><span class="ls7 ws3"> <span class="_21 blank"> </span>q<span class="_a blank"> </span>ue<span class="_1 blank"></span> <span class="_c blank"> </span>o<span class="_1 blank"></span> <span class="_21 blank"> </span>e<span class="_a blank"> </span>f<span class="_6 blank"></span>e<span class="_6 blank"></span>i<span class="_a blank"> </span>to<span class="_1 blank"></span> <span class="_c blank"> </span><span class="ls36 ws24">ou </span> <span class="_22 blank"> </span>o<span class="_6 blank"></span>c<span class="_a blank"> </span>up<span class="_1 blank"></span>a<span class="_a blank"> </span><span class="ff2 ls18 ws6">çã<span class="_a blank"> </span></span>o<span class="_6 blank"></span> <span class="_22 blank"> </span>d<span class="_a blank"> </span>os<span class="_1 blank"></span> </span></span></span></span></span></span></span></div><div class="t m0 x21 hc y69 ff1 fs9 fc2 sc0 ls7 ws3">r<span class="_a blank"> </span>e<span class="_6 blank"></span>c<span class="_6 blank"></span>e<span class="_a blank"> </span>p<span class="_6 blank"></span>t<span class="_6 blank"></span>o<span class="_a blank"> </span>re<span class="_1 blank"></span>s<span class="_2 blank"> </span> <span class="_22 blank"> </span>r<span class="_a blank"> </span>ep<span class="_1 blank"></span>r<span class="_a blank"> </span>es<span class="_1 blank"></span>e<span class="_a blank"> </span>nt<span class="_1 blank"></span>a<span class="_2 blank"> </span> <span class="_22 blank"> </span>m<span class="_2 blank"> </span>e<span class="_6 blank"></span>t<span class="_6 blank"></span>a<span class="_a blank"> </span>d<span class="_6 blank"></span>e<span class="_a blank"> </span> <span class="_21 blank"> </span><span class="ls5 ws23">do<span class="_1 blank"></span><span class="ls7 ws3"> <span class="_c blank"> </span>v<span class="_1 blank"></span>a<span class="_6 blank"></span>l<span class="_a blank"> </span>or <span class="_21 blank"> </span>m<span class="_a blank"> </span><span class="ff2 ws25">á<span class="_14 blank"></span><span class="ff1 ws3">x<span class="_2 blank"> </span>i<span class="_6 blank"></span>m<span class="_6 blank"></span>o<span class="_a blank"> </span>,<span class="_6 blank"></span> <span class="_c blank"> </span>s<span class="ff2 ws25">ã<span class="_1 blank"></span><span class="ff1 ws3">o<span class="_a blank"> </span> <span class="_21 blank"> </span>d<span class="_6 blank"></span>e<span class="_a blank"> </span>s<span class="_6 blank"></span>i<span class="_6 blank"></span>g<span class="_a blank"> </span>n<span class="_6 blank"></span>a<span class="_6 blank"></span>d<span class="_a blank"> </span>as<span class="_1 blank"></span> </span></span></span></span></span></span></div><div class="t m0 x22 hd y6a ff6 fsa fc2 sc0 ls7 ws3">Co<span class="_6 blank"></span>nst<span class="_6 blank"></span>a<span class="_a blank"> </span>nt<span class="_6 blank"></span>e<span class="_a blank"> </span> de<span class="_a blank"> </span> di<span class="_1 blank"></span>s<span class="_a blank"> </span>soc<span class="_a blank"> </span>i<span class="_6 blank"></span>a<span class="_a blank"> </span>ç<span class="_a blank"> </span>ã<span class="_2 blank"> </span>o </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div>
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