<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg1.png"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls1 ws0">Biologia do</div><div class="t m0 x2 h2 y2 ff1 fs0 fc0 sc0 ls2">Desenvolvimento</div><div class="t m0 x3 h3 y3 ff2 fs1 fc0 sc0 ls0 ws2">Q U I N T <span class="_0 blank"></span>A<span class="_0 blank"></span> E D I Ç Ã O</div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x4 y4 w2 h4" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg2.png"></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x5 y5 w3 h5" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg3.png"><div class="t m0 x6 h6 y6 ff1 fs2 fc0 sc0 ls3 ws3">Biologia do</div><div class="t m0 x7 h6 y7 ff1 fs2 fc0 sc0 ls4">Desenvolvimento</div><div class="t m0 x8 h3 y8 ff2 fs1 fc0 sc0 ls0 ws2">Q U I N T <span class="_0 blank"></span>A<span class="_0 blank"></span> E D I Ç Ã O</div><div class="t m0 x9 h7 y9 ff3 fs3 fc0 sc0 ls1 ws4">Scott F<span class="_1 blank"></span>. Gilbert</div><div class="t m0 xa h8 ya ff4 fs1 fc0 sc0 ls5 ws5">Swarthmore College</div><div class="t m0 xb h9 yb ff5 fs4 fc0 sc0 ls6 ws6">T<span class="_2 blank"></span>radução e Revisão</div><div class="t m0 xc ha yc ff2 fs5 fc0 sc0 ls7 ws1">Adolfo Max Rothschild</div><div class="t m0 xd ha yd ff2 fs5 fc0 sc0 ls8 ws7">Zuleika Rothschild</div><div class="t m0 xe ha ye ff2 fs5 fc0 sc0 ls1 ws8">Francisco <span class="_0 blank"></span>A. de Moura Duarte</div><div class="t m0 xe ha yf ff2 fs5 fc0 sc0 ls9 ws9">Maria Helena Corrêa Marques</div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y10 w4 hb" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg4.png"><div class="t m0 xf hc y11 ff6 fs4 fc1 sc0 ls21 wsc">A capa</div><div class="t m0 xf hd y12 ff2 fs6 fc1 sc0 lsa wsd">FOTOGRAFIA<span class="_0 blank"></span> DA<span class="_0 blank"></span> CAP<span class="_0 blank"></span>A:<span class="fs7 lsb wse"> O mRNA<span class="_0 blank"></span> para o Fator 8 de Crescimento</span></div><div class="t m0 xf hd y13 ff2 fs7 fc1 sc0 ls22 wsf">Fibroblástico pode ser detectado pela hibridização <span class="ff6 ls23 ws10">in situ</span><span class="ls24 ws11"> da montagem</span></div><div class="t m0 xf hd y14 ff2 fs7 fc1 sc0 ls25 ws12">total usando RNA marcado quimicamente que é complementar a</div><div class="t m0 xf hd y15 ff2 fs7 fc1 sc0 lsc ws13">essa mensagem. No embrião de pinto de 3 dias, a mensagem do <span class="ff6 ls26">Fgf8</span></div><div class="t m0 xf hd y16 ff2 fs7 fc1 sc0 ls1a ws14">é encontrada no ectoderma mais distal dos brotos dos membros, no</div><div class="t m0 xf hd y17 ff2 fs7 fc1 sc0 ls1a ws15">limite entre o cérebro posterior e o cérebro intermediário, nos somitos,</div><div class="t m0 xf hd y18 ff2 fs7 fc1 sc0 ls1a ws16">nos arcos branquiais do pescoço e na cauda em desenvolvimento. O</div><div class="t m0 xf hd y19 ff2 fs7 fc1 sc0 ls27 ws17">FGF8 é importante para diversos processos desenvolvimentais e</div><div class="t m0 xf hd y1a ff2 fs7 fc1 sc0 ls28 ws12">desempenha papéis críticos no crescimento dos membros e na</div><div class="t m0 xf hd y1b ff2 fs7 fc1 sc0 ls29 ws17">padronização do desenvolvimento do cérebro. Capítulos 3, 7 e 18.</div><div class="t m0 xf hd y1c ff2 fs7 fc1 sc0 lsc ws18">(Fotografia cortesia de E. Laufer<span class="_0 blank"></span>, C.-Y<span class="_3 blank"></span>. Y<span class="_3 blank"></span>eo e C. T<span class="_3 blank"></span>abin.)</div><div class="t m0 xf hd y1d ff2 fs6 fc1 sc0 lsd ws19">FOTOGRAFIA<span class="_0 blank"></span> DA<span class="_0 blank"></span> CONTRACAP<span class="_0 blank"></span>A:<span class="fs7 ls18 ws1a"> Fotografia de um embrião de pinto</span></div><div class="t m0 xf hd y1e ff2 fs7 fc1 sc0 ls2a ws1b">de 20-21 dias nos estágios de \u201cpipping\u201d (bicando a casca internamente)</div><div class="t m0 xf hd y1f ff2 fs7 fc1 sc0 ls2b ws1c">e pré-eclosão. Note o revestimento peridérmico proeminente na</div><div class="t m0 xf hd y20 ff2 fs7 fc1 sc0 ls2c ws12">extremidade do bico (dente do ovo), usado pelo pinto para fazer</div><div class="t m0 xf hd y21 ff2 fs7 fc1 sc0 ls10 ws1d">buracos na casca do ovo, a qual se tornou mais fina e mais quebradiça,</div><div class="t m0 xf hd y22 ff2 fs7 fc1 sc0 ls1a ws1e">como uma conseqüência da utilização de minerais pelo embrião para</div><div class="t m0 xf hd y23 ff2 fs7 fc1 sc0 ls18 ws1f">seu crescimento esquelético. Esse estágio desenvolvimental marca a</div><div class="t m0 xf hd y24 ff2 fs7 fc1 sc0 lse ws12">transição do embrião em um pinto que respira ar<span class="_3 blank"></span>. Capítulos 1 e 5.</div><div class="t m0 xf hd y25 ff2 fs7 fc1 sc0 lsf ws20">(Fotografia do <span class="ff6 ls10 ws21">International Poultry Journal</span><span class="ls11 ws22">, cortesia de R. T<span class="_3 blank"></span>uan.)</span></div><div class="t m0 xf hc y26 ff6 fs4 fc1 sc0 ls2d ws23">As páginas de título</div><div class="t m0 xf hd y27 ff2 fs6 fc1 sc0 ls12 ws24">PÁGINA<span class="_3 blank"></span> ESQUERDA:<span class="fs7 ls13 ws25"> A<span class="_3 blank"></span> expressão gênica gera limites nos discos imagi-</span></div><div class="t m0 xf hd y28 ff2 fs7 fc1 sc0 lsf ws26">nais da <span class="ff6 ls14 wsa">Drosophila</span><span class="ls18 ws27">. Os discos grandes e pequenos dentro da larva da</span></div><div class="t m0 xf hd y29 ff2 fs7 fc1 sc0 lsf ws28">mosca formam as asas e os halteres, respectivamente, no adulto. Nes-</div><div class="t m0 xf hd y2a ff2 fs7 fc1 sc0 ls15 ws29">se estágio, a proteína <span class="_0 blank"></span>Apterous (vermelho) é expressa somente nos</div><div class="t m0 xf hd y2b ff2 fs7 fc1 sc0 ls10 ws2a">compartimentos dorsais; a proteína Cubitus interruptus (azul) mar-</div><div class="t m0 xf hd y2c ff2 fs7 fc1 sc0 ls1a ws2b">ca os compartimentos anteriores (mas não os posteriores) (uma linha</div><div class="t m0 xf hd y2d ff2 fs7 fc1 sc0 ls16 ws2c">formando esse limite pode ser observ<span class="_4 blank"></span>ada). <span class="_0 blank"></span>A<span class="_4 blank"></span> coloração verde (origi-</div><div class="t m0 xf hd y2e ff2 fs7 fc1 sc0 lsf ws2d">nária da proteína V<span class="_3 blank"></span>estigial) no interior demarca o limite entre o mem-</div><div class="t m0 xf hd y2f ff2 fs7 fc1 sc0 ls11 ws2e">bro livre e a articulação ligando-o à parede torácica. Capítulo 19. (Fo-</div><div class="t m0 xf hd y30 ff2 fs7 fc1 sc0 ls18 ws2f">tografia cortesia de J. Williams, S. Paddock e S. Carroll.)</div><div class="t m0 xf hd y31 ff2 fs6 fc1 sc0 ls17 ws30">PÁGINA<span class="_0 blank"></span> DIREIT<span class="_0 blank"></span>A:<span class="fs7 ls18 ws31"> Expressão do gene <span class="ff6 ls19 wsb">paraxis</span><span class="ls11 ws32"> no embrião de pinto no</span></span></div><div class="t m0 xf hd y32 ff2 fs7 fc1 sc0 ls1a ws33">estágio de 6 somitos. Hibridização <span class="ff6 ls1b ws34">in situ</span><span class="lsf ws35"> da montagem total usando</span></div><div class="t m0 xf hd y33 ff2 fs7 fc1 sc0 ls11 ws36">RNA marcado com \u201cdigoxygenin\u201d complementar a uma porção da</div><div class="t m0 xf hd y34 ff2 fs7 fc1 sc0 ls1c ws1">mensagem <span class="_5 blank"> </span><span class="ff6 ls19 wsb">paraxis</span><span class="ls18 ws37"> do pinto mostra a expressão desse gene durante a</span></div><div class="t m0 xf hd y35 ff2 fs7 fc1 sc0 ls1a ws38">formação do somito. <span class="_0 blank"></span>A<span class="_4 blank"></span> proteína P<span class="_0 blank"></span>araxis é importante no estabeleci-</div><div class="t m0 xf hd y36 ff2 fs7 fc1 sc0 ls2e ws29">mento da estrutura desses grupos mesodérmicos. Capítulos 2 e 9.</div><div class="t m0 xf hd y37 ff2 fs7 fc1 sc0 lsf ws39">(Montagem fotográfica cortesia de R. T<span class="_3 blank"></span>uan.)</div><div class="t m0 x0 he y38 ff5 fs8 fc0 sc0 ls1d ws3a">Do original:<span class="ff2 ls1e ws3b"> Developmental biology<span class="_2 blank"></span>,</span></div><div class="t m0 x10 hf y39 ff2 fs8 fc0 sc0 ls2f ws3c">Fifth Edition</div><div class="t m0 x0 hf y3a ff2 fs8 fc0 sc0 ls30 ws3a">Copyrigth ® 1997 by Sinauer Associates,</div><div class="t m0 x10 hf y3b ff2 fs8 fc0 sc0 ls31">Inc.</div><div class="t m0 x0 he y3c ff5 fs8 fc0 sc0 ls0 ws3a">Dados Internacionais de Catalogação na</div><div class="t m0 x10 he y3d ff5 fs8 fc0 sc0 ls30 ws3a">Publicação (CIP)</div><div class="t m0 x0 he y3e ff5 fs8 fc0 sc0 ls32 ws3a">(Câmara Brasileira do livro, SP<span class="_2 blank"></span>, Brasil)</div><div class="t m0 x11 hf y3f ff2 fs8 fc0 sc0 ls32">_____________________________________</div><div class="t m0 x0 hf y40 ff2 fs8 fc0 sc0 ls1f ws3a">Gilbert, Scott F<span class="_0 blank"></span>., 1949-</div><div class="t m0 x0 hf y41 ff2 fs8 fc0 sc0 ls33 ws3a">Biologia do desenvolvimento /</div><div class="t m0 x10 hf y42 ff2 fs8 fc0 sc0 ls20 ws3d">Scott F<span class="_0 blank"></span>. Gilbert. --</div><div class="t m0 x0 hf y43 ff2 fs8 fc0 sc0 ls34 ws3a">5. ed. -- Ribeirão Preto, SP :</div><div class="t m0 x10 hf y44 ff2 fs8 fc0 sc0 ls35 ws3a">FUNPEC Editora, 2003.</div><div class="t m0 x0 hf y45 ff2 fs8 fc0 sc0 ls36 ws3a">Título original : Developmental biology</div><div class="t m0 x0 hf y46 ff2 fs8 fc0 sc0 ls37 ws3a">Vários tradutores e revisores.</div><div class="t m0 x0 hf y47 ff2 fs8 fc0 sc0 ls38">Bibliografia.</div><div class="t m0 x0 hf y48 ff2 fs8 fc0 sc0 ls39 ws3a">ISBN 85-87528-61-0</div><div class="t m0 x0 hf y49 ff2 fs8 fc0 sc0 ls3a ws3a">1. Biologia do desenvolvimento I. Título.</div><div class="t m0 x0 hf y4a ff2 fs8 fc0 sc0 ls3b ws3e">03-4459 CDD-571.8</div><div class="t m0 x11 hf y4b ff2 fs8 fc0 sc0 ls32">_____________________________________</div><div class="t m0 x0 he y4c ff5 fs8 fc0 sc0 ls20 ws3a">Índices para catálogo sitemático:</div><div class="t m0 x0 hf y4d ff2 fs8 fc0 sc0 ls31 ws3a">1. Bilogia do Desenvolvimento: Ciências</div><div class="t m0 x10 hf y4e ff2 fs8 fc0 sc0 ls20 ws3a">da vida 571.8</div><div class="t m0 x0 he y4f ff5 fs8 fc0 sc0 ls3c ws3f">Direitos para a língua portuguesa cedidos</div><div class="t m0 x10 he y50 ff5 fs8 fc0 sc0 ls32 ws3a">pela Sinauer Associates, Inc. para a</div><div class="t m0 x10 he y51 ff5 fs8 fc0 sc0 ls3b ws40">Fundação de Pesquisas Científicas de</div><div class="t m0 x10 he y52 ff5 fs8 fc0 sc0 ls3c ws41">Ribeirão Preto que se reserva a</div><div class="t m0 x10 he y53 ff5 fs8 fc0 sc0 ls3c ws42">propriedade desta tradução.</div><div class="t m0 x0 hf y54 ff2 fs8 fc0 sc0 ls3d ws3a">Proibida a reprodução dos textos</div><div class="t m0 x10 hf y55 ff2 fs8 fc0 sc0 ls3e ws3a">originais, mesmo parcial e por</div><div class="t m0 x10 hf y56 ff2 fs8 fc0 sc0 ls3f ws3a">qualquer processo, sem autorização</div><div class="t m0 x10 hf y57 ff2 fs8 fc0 sc0 ls40 ws43">da editora.</div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y58 w5 h10" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg5.png"><div class="t m0 x12 hc y59 ff6 fs4 fc0 sc0 ls41 ws44">Para Daniel, Sarah, e David</div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y5a w1 h11" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg6.png"><div class="t m0 x0 h12 y5b ff7 fs9 fc0 sc0 ls4f ws46">T<span class="_6 blank"></span>abela de Conteúdos</div><div class="t m0 x0 h13 y5c ff8 fs4 fc0 sc0 ls50 ws47">Intr<span class="_0 blank"></span>odução ao desenvolvimento</div><div class="t m0 x0 h13 y5d ff8 fs4 fc0 sc0 ls51 ws48">animal 1</div><div class="t m0 x0 h14 y5e ff8 fsa fc0 sc0 ls42 ws49">O objetivo da biologia do desenvolvimento 1</div><div class="t m0 x0 h14 y5f ff8 fsa fc0 sc0 ls42 ws4a">Os pr<span class="_4 blank"></span>oblemas da biologia do desenvolvimento 2</div><div class="t m0 x0 h14 y60 ff8 fsa fc0 sc0 ls42 ws4b">Os estágios do desenvolvimento animal 3</div><div class="t m0 x0 h14 y61 ff8 fsa fc0 sc0 ls52 ws4c">Nossa herança eucariótica 5</div><div class="t m0 x0 h14 y62 ff8 fsa fc0 sc0 ls43 ws4d">Desenvolvimento entr<span class="_4 blank"></span>e eucariotos unicelular<span class="_0 blank"></span>es 6</div><div class="t m0 x13 h15 y63 ff9 fsb fc0 sc0 ls44 ws4e">Controle da Morfogênese no Desenvolvimento em</div><div class="t m1 x14 h16 y64 ff9 fsc fc0 sc0 ls53 ws4f">Acetabulária 6</div><div class="t m0 x13 h15 y65 ff9 fsb fc0 sc0 ls4e ws50">Diferenciação em Ameboflagelados </div><div class="t m1 xc h16 y65 ff9 fsc fc0 sc0 ls54 ws51">Naegleria 10</div><div class="t m0 x13 h15 y66 ff9 fsb fc0 sc0 ls4e ws52">As Origens da Reprodução Sexual 12</div><div class="t m0 x0 h14 y67 ff8 fsa fc0 sc0 ls55 ws53">Eucariotos coloniais: A<span class="_4 blank"></span> evolução da difer<span class="_4 blank"></span>enciação <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span>16</div><div class="t m0 x13 h15 y68 ff9 fsb fc0 sc0 ls44 ws54">As <span class="_0 blank"></span>V<span class="_3 blank"></span>olvocaceanas 16</div><div class="t m0 x15 h14 y69 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y6a ffb fsc fc0 sc0 ls46 ws56">Sexo e Individualidade em <span class="_3 blank"></span>V<span class="_3 blank"></span>olv<span class="_4 blank"></span>o<span class="_0 blank"></span>x 18</div><div class="t m0 x13 h15 y6b ff9 fsb fc0 sc0 ls57 ws57">Diferenciação e Morfogênese em </div><div class="t m1 x16 h16 y6b ff9 fsc fc0 sc0 ls58 ws58">Dictyostelium 21</div><div class="t m0 x15 h14 y6c ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y6d ffb fsc fc0 sc0 ls53 ws59">Evidência e Anticorpos 25</div><div class="t m0 x15 h14 y6e ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y6f ffb fsc fc0 sc0 ls59 ws5a">Como o Grex Sabe Qual Lado Está Para Cima 27</div><div class="t m0 x0 h14 y70 ff8 fsa fc0 sc0 ls47 ws5b">Padrões desenvolvimentais entr<span class="_0 blank"></span>e metazoários 28</div><div class="t m0 x13 h15 y71 ff9 fsb fc0 sc0 ls48 ws5c">Os P<span class="_0 blank"></span>oríferos 29</div><div class="t m0 x13 h15 y72 ff9 fsb fc0 sc0 ls4e ws5d">Protostomatas e Deuterostomatas 30</div><div class="t m0 x0 h18 y73 ffc fs9 fc2 sc0 ls5a ws5e">P<span class="_7 blank"></span>ARTE I<span class="ff8 fsd fc0 ls5b ws5f"> Intr<span class="_3 blank"></span>odução à Biologia do Desenvolvimento</span></div><div class="t m0 x17 h19 y74 ffc fse fc0 sc0 ls49">1<span class="ff8 fs4 ls5c ws60 v1">Genes e desenvolvimento:</span></div><div class="t m0 x2 h13 y75 ff8 fs4 fc0 sc0 ls50 ws61">Intr<span class="_0 blank"></span>odução e técnicas 35</div><div class="t m0 x2 h14 y76 ff8 fsa fc0 sc0 ls5d ws62">As origens embriológicas da teoria dos genes 35</div><div class="t m0 x18 h15 y77 ff9 fsb fc0 sc0 ls44 ws5c">Núcleo ou Citoplasma: Qual Controla a</div><div class="t m0 x19 h15 y78 ff9 fsb fc0 sc0 ls44 ws63">Hereditariedade? 35</div><div class="t m0 x18 h15 y79 ff9 fsb fc0 sc0 ls44 ws64">O Cromossomo X como uma P<span class="_0 blank"></span>onte Entre Genes e</div><div class="t m0 x19 h15 y7a ff9 fsb fc0 sc0 ls44 ws65">Desenvolvimento 37</div><div class="t m0 x2 h14 y7b ff8 fsa fc0 sc0 ls42 ws66">A cisão entr<span class="_0 blank"></span>e a embriologia e a genética 38</div><div class="t m0 x2 h14 y7c ff8 fsa fc0 sc0 ls5e ws67">Primeiras tentativas da genética do desenvolvimento <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span>39</div><div class="t m0 x2 h14 y7d ff8 fsa fc0 sc0 ls43 ws68">Evidência para a equivalência genômica 40</div><div class="t m0 x18 h15 y7e ff9 fsb fc0 sc0 ls5f ws69">Metaplasia 40</div><div class="t m0 x18 h15 y7f ff9 fsb fc0 sc0 ls4a ws6a">Clonagem de Anfibios:<span class="_0 blank"></span> A Restrição da Potência</div><div class="t m0 x19 h15 y80 ff9 fsb fc0 sc0 ls4a ws6b">Nuclear 42</div><div class="t m0 x18 h15 y81 ff9 fsb fc0 sc0 ls44 ws6c">Clonagem de Anfíbios: A Pluripotência de Células</div><div class="t m0 x19 h15 y82 ff9 fsb fc0 sc0 ls48 ws6d">Somáticas 43</div><div class="t m0 x1a h14 y83 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y84 ffb fsc fc0 sc0 ls46 ws6e">Clonando Mamíferos por Prazer e Lucro 45</div><div class="t m0 x2 h14 y6d ff8 fsa fc0 sc0 ls60 ws1">Sobr<span class="_0 blank"></span>e<span class="_5 blank"> </span> <span class="ffd ls4c ws45">E.coli</span><span class="ls4d ws6f"> e elefantes: O modelo oper<span class="_4 blank"></span>on 47</span></div><div class="t m0 x2 h14 y85 ff8 fsa fc0 sc0 ls4c ws68">Síntese difer<span class="_0 blank"></span>encial de RNA 49</div><div class="t m0 x2 h1a y86 ff8 fsf fc0 sc0 ls61 ws70">Hibridização de ácido nucléico 54</div><div class="t m0 x2 h14 y87 ff8 fsa fc0 sc0 ls62 ws71">Clonagem de DNA genômico 55</div><div class="t m0 x2 h14 y88 ff8 fsa fc0 sc0 ls42 ws72">Hibridização de DNA: entr<span class="_0 blank"></span>e e intra espécies 58</div><div class="t m0 x2 h1a y89 ff8 fsf fc0 sc0 ls61 ws73">Seqüenciamento de DNA 59</div><div class="t m0 x2 h14 y8a ff8 fsa fc0 sc0 ls47 ws74">Análise de mRNA através de bibliotecas de cDNA 61</div><div class="t m0 x2 h14 y8b ff8 fsa fc0 sc0 ls47 ws75">Técnicas de localização de RNA 63</div><div class="t m0 x18 h15 y8c ff9 fsb fc0 sc0 ls63 ws76">Hibridização In Situ 63</div><div class="t m0 x18 h15 y8d ff9 fsb fc0 sc0 ls4e ws77">T<span class="_2 blank"></span>ransf<span class="_4 blank"></span>erências Nor<span class="_5 blank"> </span>thern 64</div><div class="t m0 x1b h1b y74 ffc fse fc0 sc0 ls3b">2</div><a class="l" data-dest-detail='[19,"FitH",789]'><div class="d m2" style="border-style:none;position:absolute;left:46.032000px;bottom:458.014000px;width:454.765000px;height:29.365000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[21,"FitH",789]'><div class="d m2" style="border-style:none;position:absolute;left:43.651000px;bottom:405.633000px;width:257.144000px;height:37.302000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[21,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:50.000200px;bottom:271.665000px;width:236.111800px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[36,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:259.443000px;width:109.444700px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[38,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:73.889100px;bottom:233.887000px;width:183.889900px;height:22.223000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[41,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:72.778000px;bottom:221.109000px;width:223.334000px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[45,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:70.000200px;bottom:124.442000px;width:181.111800px;height:10.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[55,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:408.888000px;width:251.668000px;height:36.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[55,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.334000px;bottom:384.999000px;width:219.445000px;height:12.778000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[55,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:361.110000px;width:174.445000px;height:22.778000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[57,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:335.554000px;width:228.889000px;height:23.334000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[58,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:307.223000px;bottom:322.776000px;width:201.112000px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[59,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:308.332000px;width:237.223000px;height:12.222000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[60,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:297.221000px;width:202.223000px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[60,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:283.332000px;width:75.000000px;height:12.778000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[62,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:259.998000px;width:215.556000px;height:22.223000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[63,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.001000px;bottom:234.443000px;width:225.556000px;height:22.222000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[65,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:329.445000px;bottom:207.221000px;width:218.335000px;height:25.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[67,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.890000px;bottom:192.776000px;width:206.112000px;height:13.333000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[69,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:179.443000px;width:141.112000px;height:12.222000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[74,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:167.220000px;width:178.334000px;height:11.112000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[75,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.890000px;bottom:153.887000px;width:153.889000px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[78,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.890000px;bottom:140.554000px;width:217.223000px;height:11.666000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[79,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.334000px;bottom:128.331000px;width:147.779000px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[81,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.890000px;bottom:115.554000px;width:231.667000px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[83,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.334000px;bottom:102.776000px;width:166.112000px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[83,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:89.997900px;width:115.000000px;height:10.556100px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[84,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:331.112000px;bottom:77.220100px;width:131.112000px;height:10.555600px;background-color:rgba(255,255,255,0.000001);"></div></a></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y8e w6 h1c" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg7.png"><div class="t m0 x1c h1d y8f ff8 fs6 fc0 sc0 ls64 ws1">Tabela dos Conteúdos<span class="ffd ls6a"> <span class="ffe ls6b">vii</span></span></div><div class="t m0 x0 h14 y90 ff8 fsa fc0 sc0 ls4d ws7c">Encontrando mensagens raras pela r<span class="_0 blank"></span>eação da polimerase</div><div class="t m0 x14 h14 y91 ff8 fsa fc0 sc0 ls6c ws7d">em cadeia 66</div><div class="t m0 x0 h14 y92 ff8 fsa fc0 sc0 ls47 ws7e">Determinando a função do gene: células e or<span class="_0 blank"></span>ganismos</div><div class="t m0 x14 h14 y93 ff8 fsa fc0 sc0 ls47 ws7f">transgênicos 69</div><div class="t m0 x13 h15 y94 ff9 fsb fc0 sc0 ls6d ws80">Técnicas de inserção de DNA nov<span class="_0 blank"></span>o em uma célula <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span>69</div><div class="t m0 x13 h15 y95 ff9 fsb fc0 sc0 ls48 ws81">Camundongos quiméricos 70</div><div class="t m0 x13 h15 y96 ff9 fsb fc0 sc0 ls6e ws82">Experimentos com genes com endereçamento</div><div class="t m0 x14 h15 y97 ff9 fsb fc0 sc0 ls6f ws83">(Gene targeting ou Knockout) 70</div><div class="t m0 x0 h14 y98 ff8 fsa fc0 sc0 ls70 ws84">Determinando a função de uma mensagem: RNA antisense <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_8 blank"> </span>73</div><div class="t m0 x0 h14 y99 ff8 fsa fc0 sc0 ls71 ws85">Reinvestigação de velhos pr<span class="_4 blank"></span>oblemas com novos métodos <span class="_5 blank"> </span> <span class="_5 blank"> </span>73</div><div class="t m0 x0 h14 y9a ff8 fsa fc0 sc0 ls6c ws86">Uma conclusão e um alerta 75</div><div class="t m0 x0 h13 y9b ff8 fs4 fc0 sc0 ls72 ws87">Base celular da morfogênese:</div><div class="t m0 x0 h13 y9c ff8 fs4 fc0 sc0 ls73 ws88">Afinidade celular difer<span class="_0 blank"></span>encial 79</div><div class="t m0 x0 h14 y9d ff8 fsa fc0 sc0 ls65 ws89">Afinidade celular difer<span class="_4 blank"></span>encial 80</div><div class="t m0 x13 h15 y9e ff9 fsb fc0 sc0 ls74 ws8a">O modelo termodinâmico de interações celulares 84</div><div class="t m0 x15 h14 y9f ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 ya0 ffb fsc fc0 sc0 ls75 ws8b">Evidência para o modelo termodinâmico 87</div><div class="t m0 x0 h14 ya1 ff8 fsa fc0 sc0 ls43 ws8c">A base molecular das adesões célula-célula 88</div><div class="t m0 x13 h15 ya2 ff9 fsb fc0 sc0 ls48 ws8d">As classes de moléculas de adesão celular 88</div><div class="t m0 x15 h14 ya3 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 ya4 ffb fsc fc0 sc0 ls76 ws51">Anticorpos monoclonais e genética reversa 89</div><div class="t m0 x0 h14 ya5 ff8 fsa fc0 sc0 ls42 ws8e">Moléculas de adesão celular 92</div><div class="t m0 x18 h15 y90 ff9 fsb fc0 sc0 ls4e ws8f">Identificando moléculas de adesão celular e seu</div><div class="t m0 x19 h15 ya6 ff9 fsb fc0 sc0 ls4a ws90">papel no desenvolvimento 92</div><div class="t m0 x18 h15 ya7 ff9 fsb fc0 sc0 ls63 ws91">Caderinas 92</div><div class="t m0 x18 h15 ya8 ff9 fsb fc0 sc0 ls48 ws92">CAMs da superfamília de imunoglobulinas 95</div><div class="t m0 x2 h14 y94 ff8 fsa fc0 sc0 ls47 ws93">Moléculas da junção celular: pr<span class="_0 blank"></span>oteínas da junção em</div><div class="t m0 x19 h14 ya9 ff8 fsa fc0 sc0 ls77 ws94">fenda 97</div><div class="t m0 x2 h14 yaa ff8 fsa fc0 sc0 ls47 ws74">A base molecular da afinidade célula-substrato 99</div><div class="t m0 x18 h15 yab ff9 fsb fc0 sc0 ls4e ws95">Afinidade diferencial a substrato 99</div><div class="t m0 x18 h15 yac ff9 fsb fc0 sc0 ls48 ws96">A matriz extracelular 99</div><div class="t m0 x18 h15 yad ff9 fsb fc0 sc0 ls48 ws97">Receptores celulares para moléculas da matriz</div><div class="t m0 x19 h15 yae ff9 fsb fc0 sc0 ls63 ws98">extracelular 104</div><div class="t m0 x18 h15 yaf ff9 fsb fc0 sc0 ls63 ws99">Adesão diferencial resultante de sistemas de</div><div class="t m0 x19 h15 yb0 ff9 fsb fc0 sc0 ls63 ws9a">adesão múltipla 106</div><div class="t m0 x2 h14 yb1 ff8 fsa fc0 sc0 ls78 ws9b">Moléculas de r<span class="_0 blank"></span>eceptores e vias de transdução</div><div class="t m0 x19 h14 yb2 ff8 fsa fc0 sc0 ls78 ws9c">de sinais 107</div><div class="t m0 x18 h15 yb3 ff9 fsb fc0 sc0 ls66 ws9d">A via JAK-ST<span class="_2 blank"></span>A<span class="_2 blank"></span>T 107</div><div class="t m0 x18 h15 yb4 ff9 fsb fc0 sc0 ls79 ws9e">A via RTK-Ras 108</div><div class="t m0 x1a h14 yb5 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m0 x18 h15 yb6 ff9 fsb fc0 sc0 ls7a ws9f">Mutações negativas dominantes em receptores 110</div><div class="t m0 x18 h15 yb7 ff9 fsb fc0 sc0 ls4e wsa0">A via do inositol fosfato 111</div><div class="t m0 x18 h15 yb8 ff9 fsb fc0 sc0 ls63 wsa1">Cruzamentos entre vias 112</div><div class="t m0 x18 h15 yb9 ff9 fsb fc0 sc0 ls63 wsa2">A matriz extracelular e a superfície da célula como</div><div class="t m0 x19 h15 yba ff9 fsb fc0 sc0 ls48 wsa3">fontes de sinais críticos para o</div><div class="t m0 x19 h15 ybb ff9 fsb fc0 sc0 ls44 wsa4">desenvolvimento 112</div><div class="t m0 x18 h15 ybc ff9 fsb fc0 sc0 ls44 wsa5">Interações recíprocas na superfície celular 113</div><div class="t m0 x17 h1b ybd ffc fse fc0 sc0 ls3b">3</div><div class="t m0 x0 h18 ybe ffc fs9 fc2 sc0 ls7b wsa6">P<span class="_7 blank"></span>ARTE II<span class="ff8 fsd fc0 ls7c wsa7"> Padrões de Desenvolvimento</span></div><div class="t m0 x0 h13 y7b ff8 fs4 fc0 sc0 ls7d wsa8">Fertilização: Iniciando um</div><div class="t m0 x0 h13 ybf ff8 fs4 fc0 sc0 ls51 wsa9">novo or<span class="_0 blank"></span>ganismo 121</div><div class="t m0 x0 h14 yc0 ff8 fsa fc0 sc0 ls62 wsaa">Estrutura dos gametas 121</div><div class="t m0 x13 h15 yc1 ff9 fsb fc0 sc0 ls4e wsab">Espermatozóide 121</div><div class="t m0 x13 h15 yc2 ff9 fsb fc0 sc0 ls7e wsac">O óvulo 125</div><div class="t m0 x0 h14 yc3 ff8 fsa fc0 sc0 ls47 wsad">Reconhecimento do óvulo e do espermatozóide: Ação à</div><div class="t m0 x14 h14 yc4 ff8 fsa fc0 sc0 ls4d wsae">distância 128</div><div class="t m0 x13 h15 yc5 ff9 fsb fc0 sc0 ls4e wsaf">Atração do Espermatozóide 128</div><div class="t m0 x13 h15 yc6 ff9 fsb fc0 sc0 ls7f wsb0">Ativação Espermática: A Reação Acrossômica no</div><div class="t m0 x14 h15 yc7 ff9 fsb fc0 sc0 ls48 wsb1">Ouriço-do-Mar 129</div><div class="t m0 x15 h14 yc8 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 yc9 ffb fsc fc0 sc0 ls80 wsb2">Ação à Distância: Gametas de Mamíferos 131</div><div class="t m0 x13 h15 yca ff9 fsb fc0 sc0 ls81 wsb3">Reconhecimento do óvulo e espermatozóide:</div><div class="t m0 x14 h15 ycb ff9 fsb fc0 sc0 ls81 wsb4">Contato de gametas 132</div><div class="t m0 x13 h15 ycc ff9 fsb fc0 sc0 ls82 wsb5">Reconhecimento Espécie-Específico em Ouriços-</div><div class="t m0 x14 h15 ycd ff9 fsb fc0 sc0 ls5f wsb6">do-Mar 132</div><div class="t m0 x13 h15 yce ff9 fsb fc0 sc0 ls44 wsb7">Ligação de Gametas e Reconhecimento em</div><div class="t m0 x14 h15 ycf ff9 fsb fc0 sc0 ls44 wsb8">Mamíferos 135</div><div class="t m0 x0 h14 yd0 ff8 fsa fc0 sc0 ls83 wsb9">Fusão de gametas e a pr<span class="_4 blank"></span>evenção da polispermia <span class="_5 blank"> </span> 139</div><div class="t m0 x13 h15 yd1 ff9 fsb fc0 sc0 ls4e wsba">Fusão entre as membranas do óvulo e do</div><div class="t m0 x14 h15 yd2 ff9 fsb fc0 sc0 ls6f wsbb">espermatozóide 139</div><div class="t m0 x18 h15 yd3 ff9 fsb fc0 sc0 ls63 wsba">Pre<span class="_4 blank"></span>v<span class="_4 blank"></span>enção da P<span class="_0 blank"></span>olisper<span class="_5 blank"> </span>mia 140</div><div class="t m0 x1a h14 yd4 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 yd5 ffb fsc fc0 sc0 ls80 wsbc">A Ativação do Metabolismo dos Gametas 147</div><div class="t m0 x2 h14 yd6 ff8 fsa fc0 sc0 ls42 wsbd">Ativação do metabolismo do óvulo 149</div><div class="t m0 x18 h15 yd7 ff9 fsb fc0 sc0 ls48 wsbe">Respostas precoces 149</div><div class="t m0 x18 h15 yd8 ff9 fsb fc0 sc0 ls44 wsbf">Respostas tardias 151</div><div class="t m0 x18 h15 yd9 ff9 fsb fc0 sc0 ls44 wsc0">Fusão do material genético 152</div><div class="t m0 x1a h14 yda ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 ydb ffb fsc fc0 sc0 ls75 wsc1">A Não-Equivalência dos Pronúcleos de</div><div class="t m1 x19 h17 ydc ffb fsc fc0 sc0 ls84 wsc2">Mamíferos 154</div><div class="t m0 x2 h14 ydd ff8 fsa fc0 sc0 ls4d wsc3">Rearranjo do citoplasma do óvulo 156</div><div class="t m0 x18 h15 yde ff9 fsb fc0 sc0 ls4e wsc4">Preparação para a Clivagem 158</div><div class="t m0 x2 h13 ydf ff8 fs4 fc0 sc0 ls72 wsc5">Clivagem: Criando</div><div class="t m0 x2 h13 ye0 ff8 fs4 fc0 sc0 ls85 wsc6">multicelularidade 167</div><div class="t m0 x2 h14 ye1 ffd fsa fc0 sc0 ls43">P<span class="fs10 ls67 ws78">ADRÕES</span><span class="ls68 ws1"> </span><span class="fs10 ls86 ws79">DE</span><span class="ls87 ws1"> C<span class="_0 blank"></span><span class="fs10 ls88 ws7a">LIV<span class="_3 blank"></span>AGEM<span class="fsa ls89 ws1"> E<span class="_4 blank"></span><span class="fs10 ls8a ws7b">MBRIONÁRIA<span class="ff8 fsa ls69 ws1"> <span class="ffd ls4d">168</span></span></span></span></span></span></div><div class="t m0 x2 h14 ye2 ff8 fsa fc0 sc0 ls47 wsc7">Clivagem holoblástica radial 169</div><div class="t m0 x18 h15 ye3 ff9 fsb fc0 sc0 ls81 wsc8">A holotúria, Synapta 169</div><div class="t m0 x18 h15 ye4 ff9 fsb fc0 sc0 ls48 wsb1">Ouriço-do-Mar 170</div><div class="t m0 x18 h15 ye5 ff9 fsb fc0 sc0 ls63 wsa1">Anfíbios 173</div><div class="t m0 x2 h14 ye6 ff8 fsa fc0 sc0 ls43 ws55">Clivagem holoblástica espiral 175</div><div class="t m0 x17 h1b ye7 ffc fse fc0 sc0 ls3b">4</div><div class="t m0 x1b h1b ye8 ffc fse fc0 sc0 ls3b">5</div><a class="l" 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class="t m0 x0 h1d y8f ffe fs6 fc0 sc0 ls20 wsc9">viii<span class="ffd ls8b wsd3"> <span class="ff8 ls8c wsd4">T<span class="_3 blank"></span>abela dos Conteúdos</span></span></div><div class="t m0 x15 h14 y90 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y91 ffb fsc fc0 sc0 ls98 wsd5">Adaptação pela modificação da clivagem</div><div class="t m1 x14 h17 yea ffb fsc fc0 sc0 ls98 wsd6">embrionária 178</div><div class="t m0 x13 h15 y93 ff9 fsb fc0 sc0 ls48 wsd7">Clivagem Holoblástica Bilateral 179</div><div class="t m0 x0 h14 y94 ff8 fsa fc0 sc0 ls47 ws4b">Clivagem holoblástica r<span class="_0 blank"></span>otacional 180</div><div class="t m0 x13 h15 ya9 ff9 fsb fc0 sc0 ls48 wsd8">Compactação 181</div><div class="t m0 x15 h14 yaa ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 yab ffb fsc fc0 sc0 ls99 wsd9">A Superfície da Célula e o Mecanismo de</div><div class="t m1 x14 h17 yac ffb fsc fc0 sc0 ls46 wsda">Compactação 184</div><div class="t m0 x13 h15 y99 ff9 fsb fc0 sc0 ls63 ws81">Formação da massa celular interna 185</div><div class="t m0 x13 h15 yeb ff9 fsb fc0 sc0 ls4a wsdb">Fuga da Zona P<span class="_0 blank"></span>elúcida 185</div><div class="t m0 x15 h14 yec ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 yed ffb fsc fc0 sc0 ls9a wsdc">Gêmeos e células embrionárias precursoras <span class="_5 blank"> </span>186</div><div class="t m0 x0 h14 yb1 ff8 fsa fc0 sc0 ls43 wsdd">Clivagem Mer<span class="_4 blank"></span>oblástica 188</div><div class="t m0 x13 h15 yb2 ff9 fsb fc0 sc0 ls79 wsde">Clivagem discoidal 189</div><div class="t m0 x13 h15 yee ff9 fsb fc0 sc0 ls79 wsdf">Clivagem Superficial 192</div><div class="t m0 x15 h14 yef ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 yb5 ffb fsc fc0 sc0 ls9b wse0">Exceções, Generalizações, e Clivagem</div><div class="t m1 x14 h17 yf0 ffb fsc fc0 sc0 ls8d wse1">P<span class="_4 blank"></span>arasítica da <span class="_3 blank"></span>V<span class="_0 blank"></span>espa 195</div><div class="t m0 x0 h14 yf1 ffd fsa fc0 sc0 ls8e">M<span class="fs10 ls9c wsca">ECANISMO</span><span class="ls8f ws1"> </span><span class="fs10 ls86 ws79">DE</span><span class="ls9d ws1"> C</span><span class="fs10 ls88 wscb">LIV<span class="_3 blank"></span>AGEM<span class="ff8 fsa ls90 ws1"> <span class="ffd ls4d">196</span></span></span></div><div class="t m0 x0 h14 yf2 ff8 fsa fc0 sc0 ls42 wse2">Regulando o ciclo da clivagem 196</div><div class="t m0 x13 h15 yf3 ff9 fsb fc0 sc0 ls81 wse3">F<span class="_0 blank"></span>ator promotor de maturação 197</div><div class="t m0 x15 h14 yf4 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y75 ffb fsc fc0 sc0 ls54 wse4">MPF e Seus Reguladores 198</div><div class="t m0 x0 h14 yf5 ff8 fsa fc0 sc0 ls42 wse5">O mecanismo citoesquelético da mitose 201</div><div class="t m0 x0 h14 yf6 ff8 fsa fc0 sc0 ls52 wse6">A formação de novas membranas 203</div><div class="t m0 x0 h13 yf7 ff8 fs4 fc0 sc0 ls9e wse7">Gastrulação: Reor<span class="_0 blank"></span>ganizando as</div><div class="t m0 x0 h13 yf8 ff8 fs4 fc0 sc0 ls9f wse8">células embrionárias 209</div><div class="t m0 x0 h14 yf9 ff8 fsa fc0 sc0 ls5d wse9">Gastrulação em ouriço-do-mar 210</div><div class="t m0 x13 h15 yfa ff9 fsb fc0 sc0 ls79 wsea">Ingresso do Mesênquima Primário 210</div><div class="t m0 x13 h15 yfb ff9 fsb fc0 sc0 ls57 ws9e">Primeiro estágio da invaginação do arquêntero 215</div><div class="t m0 x13 h15 yfc ff9 fsb fc0 sc0 ls4e ws50">Segundo e terceiro estágios da invaginação do</div><div class="t m0 x14 h15 yfd ff9 fsb fc0 sc0 lsa0 wseb">arquêntero 217</div><div class="t m0 x0 h14 yfe ff8 fsa fc0 sc0 ls4d wsec">Gastrulação em peixes 218</div><div class="t m0 x13 h15 yff ff9 fsb fc0 sc0 ls63 wsed">A transição da blástula intermediária e a aquisição</div><div class="t m0 x14 h15 y100 ff9 fsb fc0 sc0 ls48 wsee">de motilidade celular 218</div><div class="t m0 x13 h15 y101 ff9 fsb fc0 sc0 ls63 wsef">Formação das camadas germinais 220</div><div class="t m0 x0 h14 y102 ff8 fsa fc0 sc0 ls5d wsc7">Gastrulação de anfíbios 221</div><div class="t m0 x13 h15 y103 ff9 fsb fc0 sc0 ls63 wsf0">Movimentos celulares durante a gastrulação de</div><div class="t m0 x14 h15 y104 ff9 fsb fc0 sc0 ls6f wsd8">anfíbios 221</div><div class="t m0 x13 h15 y105 ff9 fsb fc0 sc0 ls4e wsf1">P<span class="_0 blank"></span>osicionando o blastóporo 224</div><div class="t m0 x13 h15 y106 ff9 fsb fc0 sc0 lsa1 wsf2">Movimentos celulares e a construção do arquêntero <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_8 blank"> </span> <span class="_5 blank"> </span>226</div><div class="t m0 x13 h15 y107 ff9 fsb fc0 sc0 ls79 wsf3">Migração do mesoderma involutivo 229</div><div class="t m0 x15 h14 y108 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y109 ffb fsc fc0 sc0 ls91 wsf4">Reguladores moleculares do desen<span class="_0 blank"></span>volvimento:</div><div class="t m1 x13 h17 y10a ffb fsc fc0 sc0 ls54 wsf5">Fibronectinas e as vias da migração</div><div class="t m1 x13 h17 y10b ffb fsc fc0 sc0 ls98 wsf6">mesodérmica 230</div><div class="t m0 x13 h15 y10c ff9 fsb fc0 sc0 ls81 wsf7">Epibolia do ectoderma 232</div><div class="t m0 x0 h14 y10d ff8 fsa fc0 sc0 ls52 wsf8">Gastrulação em aves 233</div><div class="t m0 x13 h15 y10e ff9 fsb fc0 sc0 ls44 wsf9">Generalidades sobre gastrulação em aves 233</div><div class="t m0 x17 h1b y10f ffc fse fc0 sc0 ls3b">6</div><div class="t m0 x18 h15 y90 ff9 fsb fc0 sc0 ls63 ws8d">Mecanismos de gastrulação em aves 238</div><div class="t m0 x2 h14 y91 ff8 fsa fc0 sc0 ls4d wsfa">Gastrulação em mamífer<span class="_0 blank"></span>os 242</div><div class="t m0 x18 h15 y92 ff9 fsb fc0 sc0 ls44 wsfb">Modificações para desenvolvimento dentro de</div><div class="t m0 x19 h15 y110 ff9 fsb fc0 sc0 ls4e wsfc">outro organismo 242</div><div class="t m0 x18 h15 y111 ff9 fsb fc0 sc0 ls48 wsfd">Formação de membranas extra-embrionárias 245</div><div class="t m0 x2 h13 y112 fff fs4 fc0 sc0 lsa2 wsfe">Início do d<span class="ff8">esenvolvimento <span class="ff10">vertebrado</span>:</span></div><div class="t m0 x2 h13 y113 ff8 fs4 fc0 sc0 ls9f wsff">Neurulação e ectoderma 253</div><div class="t m0 x2 h14 y114 ffd fsa fc0 sc0 ls43">F<span class="fs10 lsa3 wscc">ORMAÇÃO</span><span class="ls92 ws1"> </span><span class="fs10 lsa4 wscd">DO</span><span class="lsa5 ws1"> S<span class="_0 blank"></span><span class="fs10 ls93 wsce">ISTEMA<span class="fsa lsa6 ws1"> N<span class="_0 blank"></span><span class="fs10 ls93 wscf">ER<span class="_0 blank"></span>VOSO<span class="fsa ls94 ws1"> C<span class="_0 blank"></span><span class="fs10 lsa7 wsd0">ENTRAL<span class="ff8 fsa ls94 ws1"> <span class="ffd ls4d">254</span></span></span></span></span></span></span></span></div><div class="t m0 x2 h14 y115 ff8 fsa fc0 sc0 ls42 ws1">Neurulação: aspectos gerais 254</div><div class="t m0 x18 h15 y116 ff9 fsb fc0 sc0 ls79 ws100">Neurulação primária 255</div><div class="t m0 x18 h15 y117 ff9 fsb fc0 sc0 ls63 ws101">A mecânica da neurulação primária 257</div><div class="t m0 x18 h15 y118 ff9 fsb fc0 sc0 ls63 ws102">A formação da placa neural 257</div><div class="t m0 x18 h15 y119 ff9 fsb fc0 sc0 ls81 ws103">Formação do assoalho da placa neural 258</div><div class="t m0 x18 h15 y11a ff9 fsb fc0 sc0 ls81 ws103">A modelagem e dobramento da placa neural 259</div><div class="t m0 x18 h15 y11b ff9 fsb fc0 sc0 ls81 ws104">Fechamento do tubo neural 260</div><div class="t m0 x1a h14 y11c ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y11d ffb fsc fc0 sc0 lsa8 ws105">A modelagem dorsoventral do sistema nervoso 264</div><div class="t m0 x2 h14 y11e ff8 fsa fc0 sc0 ls4d ws106">Neurulação secundária 264</div><div class="t m0 x2 h14 y11f ff8 fsa fc0 sc0 ls42 ws107">Difer<span class="_0 blank"></span>enciação do tubo neural 265</div><div class="t m0 x18 h15 y120 ff9 fsb fc0 sc0 ls48 ws98">Formação das regiões do cérebro 265</div><div class="t m0 x1a h14 y121 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y122 ffb fsc fc0 sc0 ls75 ws108">Determinando as regiões do cérebro anterior e</div><div class="t m1 x19 h17 y123 ffb fsc fc0 sc0 ls84 ws109">cérebro médio 268</div><div class="t m0 x18 h15 y124 ff9 fsb fc0 sc0 lsa9 ws10a">Arquitetura de <span class="_3 blank"></span>T<span class="_3 blank"></span>ecido no Sistema Ner<span class="_5 blank"> </span>voso Centr<span class="_4 blank"></span>al 270</div><div class="t m0 x18 h15 y125 ff9 fsb fc0 sc0 ls4a ws10b">Organização do cerebelo 272</div><div class="t m0 x18 h15 y126 ff9 fsb fc0 sc0 ls63 ws10c">Organização cerebral 274</div><div class="t m0 x2 h14 y127 ff8 fsa fc0 sc0 ls52 ws10d">T<span class="_0 blank"></span>ipos de neurônios 276</div><div class="t m0 x2 h14 y128 ff8 fsa fc0 sc0 ls42 ws10e">Desenvolvimento do olho em vertebrados 279</div><div class="t m0 x18 h15 y129 ff9 fsb fc0 sc0 ls79 ws10f">Dinâmica do desenvolvimento ótico 279</div><div class="t m0 x18 h15 y12a ff9 fsb fc0 sc0 ls44 ws110">Diferenciação da retina neural 280</div><div class="t m0 x1a h14 y12b ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y12c ffb fsc fc0 sc0 ls75 ws111">P<span class="_0 blank"></span>orque os bebês não enxergam bem 282</div><div class="t m0 x18 h15 y12d ff9 fsb fc0 sc0 ls79 ws112">Diferenciação do cristalino e da córnea 283</div><div class="t m0 x2 h14 y12e ffd fsa fc0 sc0 lsaa ws113">A C<span class="_8 blank"> </span><span class="fs10 ls95 wsd1">RIST<span class="_3 blank"></span>A<span class="fsa lsab ws1"> N</span><span class="lsac wsd2">EURAL<span class="ff8 fsa ls96 ws1"> <span class="ffd ls4d">284</span></span></span></span></div><div class="t m0 x2 h14 y12f ff8 fsa fc0 sc0 ls62 wse9">A crista neural e seus derivados 284</div><div class="t m0 x2 h14 y130 ff8 fsa fc0 sc0 ls47 ws114">A crista neural do tr<span class="_0 blank"></span>onco 285</div><div class="t m0 x18 h15 y131 ff9 fsb fc0 sc0 ls48 ws115">Vias de migração das células da crista neural do</div><div class="t m0 x19 h15 y132 ff9 fsb fc0 sc0 ls63 ws116">tronco 285</div><div class="t m0 x18 h15 y133 ff9 fsb fc0 sc0 ls79 ws117">A matriz extracelular e a migração da crista neural</div><div class="t m0 x19 h15 y134 ff9 fsb fc0 sc0 ls6f ws100">do tronco 287</div><div class="t m0 x1a h14 y135 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y136 ffb fsc fc0 sc0 ls75 ws118">Análise das mutações que af<span class="_4 blank"></span>etam o desen<span class="_0 blank"></span>volvi-</div><div class="t m1 x19 h17 y137 ffb fsc fc0 sc0 ls53 ws119">mento das células da crista neural 290</div><div class="t m0 x2 h14 y138 ff8 fsa fc0 sc0 ls43 ws11a">A potência do desenvolvimento das células da crista</div><div class="t m0 x19 h14 y139 ff8 fsa fc0 sc0 ls43 ws11b">neural do tr<span class="_0 blank"></span>onco 291</div><div class="t m0 x18 h15 y13a ff9 fsb fc0 sc0 lsad wsbb">Diferenciação final das células da crista neural 292</div><div class="t m0 x2 h14 y13b ff8 fsa fc0 sc0 ls47 ws11c">A crista neural cefálica 293</div><div class="t m0 x18 h15 y13c ff9 fsb fc0 sc0 ls79 ws11d">Vias migratórias das células da crista neural</div><div class="t m0 x19 h15 y13d ff9 fsb fc0 sc0 ls6f ws11e">cefálica 293</div><div class="t m0 x18 h15 y13e ff9 fsb fc0 sc0 ls97 ws82">P<span class="_0 blank"></span>otência de desenv<span class="_0 blank"></span>olvimento das células da cr<span class="_5 blank"> </span>ista</div><div class="t m0 x19 h15 y13f ff9 fsb fc0 sc0 ls81 ws11f">neural cefálica 295</div><div class="t m0 x1b h1b y140 ffc fse fc0 sc0 ls3b">7</div><a class="l" data-dest-detail='[198,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:674.444000px;width:197.778700px;height:35.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[199,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:68.889100px;bottom:661.111000px;width:173.333900px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[200,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:49.444600px;bottom:647.777000px;width:173.889400px;height:11.112000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[201,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:635.000000px;width:92.777700px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[204,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.555800px;bottom:597.777000px;width:198.889200px;height:35.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[205,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:583.333000px;width:189.444700px;height:12.778000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[205,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.555800px;bottom:572.777000px;width:133.889200px;height:10.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[206,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:546.666000px;width:226.667700px;height:23.333000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[208,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:46.111200px;bottom:534.999000px;width:136.666800px;height:10.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[209,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.666900px;bottom:521.666000px;width:115.556100px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[212,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:508.888000px;width:121.666700px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[215,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.666900px;bottom:472.221000px;width:183.889100px;height:35.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[216,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:48.333500px;bottom:458.332000px;width:137.778500px;height:12.223000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[216,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:47.777900px;bottom:446.110000px;width:168.889100px;height:10.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[217,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:433.888000px;width:160.000700px;height:12.222000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[218,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.666900px;bottom:407.777000px;width:175.000100px;height:23.889000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[221,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:48.333500px;bottom:394.999000px;width:199.445500px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[223,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:48.889000px;bottom:382.777000px;width:176.112000px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[258,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:698.333000px;width:196.667000px;height:11.667000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[262,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:307.779000px;bottom:685.000000px;width:148.334000px;height:12.778000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[262,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:660.555000px;width:202.222000px;height:23.889000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[265,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:645.000000px;width:230.556000px;height:13.889000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[273,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:309.445000px;bottom:89.997900px;width:132.779000px;height:11.111100px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[313,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:331.112000px;bottom:66.109000px;width:198.334000px;height:22.222300px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[315,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:331.112000px;bottom:41.108900px;width:227.779000px;height:22.777900px;background-color:rgba(255,255,255,0.000001);"></div></a></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y141 w6 h1f" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bg9.png"><div class="t m0 x1d h1d y8f ff8 fs6 fc0 sc0 ls64 ws1">Tabela dos Conteúdos<span class="ffd ls6a"> <span class="ffe lsbb">ix</span></span></div><div class="t m0 x0 h14 y90 ff8 fsa fc0 sc0 ls62 ws8e">A crista neural car<span class="_0 blank"></span>díaca 296</div><div class="t m0 x0 h14 y91 ffd fsa fc0 sc0 lsaa ws128">A E<span class="_5 blank"> </span><span class="fs10 lsae ws120">PIDERME</span><span class="ls92 ws1"> <span class="fs10 lsaf">E</span><span class="ls68"> <span class="fs10 lsb0">A</span><span class="lsbc"> O<span class="_0 blank"></span><span class="fs10 lsb1 ws121">RIGEM<span class="fsa ls92 ws1"> </span><span class="lsbd ws122">DAS<span class="fsa ls89 ws1"> E<span class="_4 blank"></span><span class="fs10 lsb2 ws123">STRUTURAS<span class="fsa ls87 ws1"> C<span class="_0 blank"></span><span class="fs10 lsb3 ws124">UTÂNEAS<span class="ff8 fsa lsb4 ws1"> <span class="ffd ls4d">297</span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x13 h15 y92 ff9 fsb fc0 sc0 ls48 ws129">A origem das células epidérmicas 297</div><div class="t m0 x13 h15 y110 ff9 fsb fc0 sc0 ls81 ws12a">Apêndices cutâneos 299</div><div class="t m0 x0 h14 y94 ff8 fsa fc0 sc0 ls42 ws12b">Conclusões 300</div><div class="t m0 x0 h13 y142 ff8 fs4 fc0 sc0 ls85 ws12c">Especificidade <span class="ff10">a</span>xônica 307</div><div class="t m0 x0 h14 y143 ff8 fsa fc0 sc0 ls4d ws12d">A geração da diversidade neur<span class="_0 blank"></span>onial 307</div><div class="t m0 x13 h15 y144 ff9 fsb fc0 sc0 ls7a ws9a">Especificação do Neurônio Motor de <span class="_0 blank"></span>V<span class="_0 blank"></span>er<span class="_5 blank"> </span>tebrado 308</div><div class="t m0 x13 h15 y145 ff9 fsb fc0 sc0 lsbe ws82">Especificação dos Neurônios Motores em</div><div class="t m0 x14 h15 y146 ff9 fsb fc0 sc0 ls4e ws12e">Drosophila 310</div><div class="t m0 x0 h14 y147 ff8 fsa fc0 sc0 ls62 ws12f">Formação de padrões no sistema nervoso 312</div><div class="t m0 x0 h14 y148 ff8 fsa fc0 sc0 ls43 ws130">Seleção de trajetórias: Orientação pela matriz</div><div class="t m0 x14 h14 y149 ff8 fsa fc0 sc0 ls43 ws131">extracelular 313</div><div class="t m0 x13 h15 y14a ff9 fsb fc0 sc0 ls48 ws132">Orientação pelo <span class="_4 blank"></span>T<span class="_2 blank"></span>erreno Físico:<span class="_0 blank"></span> Or<span class="_5 blank"> </span>ientação por</div><div class="t m0 x14 h15 y14b ff9 fsb fc0 sc0 lsbf ws133">Contato 313</div><div class="t m0 x13 h15 y14c ff9 fsb fc0 sc0 ls4a wsbb">Orientação para Gradientes de Adesão:</div><div class="t m0 x14 h15 y14d ff9 fsb fc0 sc0 ls4a ws134">Haptotaxia 314</div><div class="t m0 x13 h15 y14e ff9 fsb fc0 sc0 ls97 ws82">Condução por Sinais Migratórios específicos</div><div class="t m0 x14 h15 y14f ff9 fsb fc0 sc0 ls57 ws135">do<span class="_5 blank"> </span> Axônio:<span class="_4 blank"></span> A Hipótese das <span class="_0 blank"></span>T<span class="_3 blank"></span>r<span class="_4 blank"></span>ajetórias</div><div class="t m0 x14 h15 y150 ff9 fsb fc0 sc0 lsad ws136">Marcadas 315</div><div class="t m0 x13 h15 y151 ff9 fsb fc0 sc0 ls4e ws137">Orientação pela Repulsão Específica de Cones de</div><div class="t m0 x14 h15 y152 ff9 fsb fc0 sc0 ls63 ws69">Crescimento 317</div><div class="t m0 x15 h14 y153 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y154 ffb fsc fc0 sc0 ls84 ws138">Sexo,Odor e Adesão Específica 319</div><div class="t m0 x0 h14 y155 ff8 fsa fc0 sc0 ls47 ws139">Seleção de trajetória: Orientação por moléculas</div><div class="t m0 x14 h14 y156 ff8 fsa fc0 sc0 ls47 ws13a">difusíveis 320</div><div class="t m0 x0 h14 y157 ff8 fsa fc0 sc0 ls47 ws11a">Sinais para condução múltipla 323</div><div class="t m0 x13 h15 y158 ff9 fsb fc0 sc0 ls44 ws13b">Neurônios Motores <span class="_0 blank"></span>V<span class="_0 blank"></span>er<span class="_5 blank"> </span>tebrados 323</div><div class="t m0 x13 h15 y159 ff9 fsb fc0 sc0 ls44 ws13c">Axônios da Retina 325</div><div class="t m0 x0 h14 y15a ff8 fsa fc0 sc0 ls4d ws13d">Seleções de alvos 326</div><div class="t m0 x13 h15 y15b ff9 fsb fc0 sc0 lsc0 ws82">Especificidades Adesivas em Diferentes Regiões</div><div class="t m0 x14 h15 y15c ff9 fsb fc0 sc0 ls6f ws13e">do <span class="_0 blank"></span>T<span class="_3 blank"></span>ectum 328</div><div class="t m0 x0 h14 y15d ff8 fsa fc0 sc0 lsb5 ws13f">Seleção de ender<span class="_0 blank"></span>eço: Desenvolvimento dependente de</div><div class="t m0 x14 h14 y15e ff8 fsa fc0 sc0 ls62 ws140">atividade 331</div><div class="t m0 x0 h14 y15f ff8 fsa fc0 sc0 ls56 ws10e">Sobr<span class="_0 blank"></span>evivência difer<span class="_4 blank"></span>encial após a inervação: Fator<span class="_0 blank"></span>es</div><div class="t m0 x14 h14 y49 ff8 fsa fc0 sc0 lsb6 ws141">neur<span class="_0 blank"></span>otróficos 331</div><div class="t m0 x15 h14 y160 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y161 ffb fsc fc0 sc0 lsc1 ws142">Neurônios Fetais em Hospedeiros Adultos 334</div><div class="t m0 x0 h14 y162 ff8 fsa fc0 sc0 ls47 ws143">O desenvolvimento de comportamentos: constância e</div><div class="t m0 x14 h14 y163 ff8 fsa fc0 sc0 ls56 ws144">plasticidade 334</div><div class="t m0 x17 h1b y164 ffc fse fc0 sc0 ls3b">8</div><div class="t m0 x2 h13 y165 fff fs4 fc0 sc0 lsc2 ws60">Início do d<span class="ff8">esenvolvimento </span></div><div class="t m0 x2 h13 y166 fff fs4 fc0 sc0 lsc3">vertebrado<span class="ff8 ws145">: Mesoderma e</span></div><div class="t m0 x2 h13 y167 ff8 fs4 fc0 sc0 ls73 ws1">endoderma 341</div><div class="t m0 x2 h14 y168 ffd fsa fc0 sc0 lsb7">M<span class="fs10 lsb8 ws125">ESODERMA</span><span class="ff8 lsb4 ws1"> </span><span class="ls4d">341</span></div><div class="t m0 x2 h14 y169 ff8 fsa fc0 sc0 ls47 ws146">Mesoderma dorsal: <span class="_4 blank"></span>A notocor<span class="_0 blank"></span>da e a difer<span class="_4 blank"></span>enciação dos</div><div class="t m0 x19 h14 y16a ff8 fsa fc0 sc0 ls77 ws147">somitos 341</div><div class="t m0 x18 h15 y16b ff9 fsb fc0 sc0 lsb9 ws148">Mesoder<span class="_5 blank"> </span>ma P<span class="_0 blank"></span>araxial 341</div><div class="t m0 x18 h15 y16c ff9 fsb fc0 sc0 ls63 ws6c">Somitômeros e a Iniciação da Formação do</div><div class="t m0 x19 h15 y16d ff9 fsb fc0 sc0 lsc4 ws69">Somito 343</div><div class="t m0 x18 h15 y16e ff9 fsb fc0 sc0 ls44 ws149">Geração de <span class="_0 blank"></span>Tipos de Células Somíticas 344</div><div class="t m0 x18 h15 y16f ff9 fsb fc0 sc0 lsc5 ws14a">Miogênese: Diferenciação do Músculo</div><div class="t m0 x19 h15 y170 ff9 fsb fc0 sc0 lsc6 ws14b">Esquelético 347</div><div class="t m0 x1a h14 y171 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y172 ffb fsc fc0 sc0 ls99 ws14c">Construção Muscular e a Família MyoD de</div><div class="t m1 x19 h17 y173 ffb fsc fc0 sc0 ls54 ws14d">Reguladores <span class="_3 blank"></span>T<span class="_3 blank"></span>ranscricionais 349</div><div class="t m0 x18 h15 y174 ff9 fsb fc0 sc0 lsc7 ws82">Osteogênese: O Desenvolvimento</div><div class="t m0 x19 h15 y175 ff9 fsb fc0 sc0 ls44 ws14e">dos Ossos 351</div><div class="t m0 x1a h14 y176 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y177 ffb fsc fc0 sc0 ls99 ws14f">Controle da Condrogênese na Placa de</div><div class="t m1 x19 h17 y178 ffb fsc fc0 sc0 ls80 ws150">Crescimento 357</div><div class="t m0 x2 h14 y179 ff8 fsa fc0 sc0 ls5d ws151">Mesoderma da Placa Lateral 358</div><div class="t m0 x18 h15 y17a ff9 fsb fc0 sc0 lsc8 ws82">Formação das Membranas</div><div class="t m0 x19 h15 y17b ff9 fsb fc0 sc0 lsc9 ws152">Extra-Embrionárias 359</div><div class="t m0 x18 h15 y17c ff9 fsb fc0 sc0 ls81 ws153">O Coração 361</div><div class="t m0 x18 h15 y17d ff9 fsb fc0 sc0 ls81 ws154">Formação dos vasos sangüíneos 366</div><div class="t m0 x1a h14 y17e ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y17f ffb fsc fc0 sc0 lsca ws155">Redirecionando o Fluxo Sangüíneo no</div><div class="t m1 x19 h17 y180 ffb fsc fc0 sc0 ls80 ws156">Mamífero Recém-nascido 372</div><div class="t m0 x2 h14 y181 ff8 fsa fc0 sc0 ls42 ws4b">O Desenvolvimento de células sangüíneas 373</div><div class="t m0 x18 h15 y182 ff9 fsb fc0 sc0 ls81 ws157">O Conceito de Célula-tronco 373</div><div class="t m0 x18 h15 y183 ff9 fsb fc0 sc0 lscb wsb5">Células-tronco Pluripotenciais e Microambientes</div><div class="t m0 x19 h15 y184 ff9 fsb fc0 sc0 ls4e wsab">Hematopoéticos 374</div><div class="t m0 x18 h15 y185 ff9 fsb fc0 sc0 ls6f wsb0">Desenvolvimento Osteoclástico 377</div><div class="t m0 x18 h15 y186 ff9 fsb fc0 sc0 ls44 ws158">Locais de Hematopoiese 378</div><div class="t m0 x2 h14 y187 ffd fsa fc0 sc0 ls3b ws126">E<span class="fs10 lsa7 ws127">NDODERMA</span><span class="ff8 lsba ws1"> </span><span class="ls4d">380</span></div><div class="t m0 x2 h14 y188 ff8 fsa fc0 sc0 ls77 ws159">Faringe 380</div><div class="t m0 x2 h14 y189 ff8 fsa fc0 sc0 ls5d ws147">O tubo digestivo e seus derivados 382</div><div class="t m0 x18 h15 y18a ff9 fsb fc0 sc0 ls6f ws15a">Fígado<span class="_0 blank"></span>, Pâncreas e <span class="_0 blank"></span>V<span class="_0 blank"></span>esícula Biliar 382</div><div class="t m0 x18 h15 y18b ff9 fsb fc0 sc0 ls4a ws15b">O T<span class="_2 blank"></span>ubo <span class="_5 blank"> </span>Respiratório <span class="_8 blank"> </span>383</div><div class="t m0 x1b h1b y18c ffc fse fc0 sc0 ls3b">9</div><a class="l" data-dest-detail='[316,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:71.666900px;bottom:469.444000px;width:177.778100px;height:23.333000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[335,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.666900px;bottom:432.221000px;width:200.000100px;height:34.445000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[337,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.000200px;bottom:405.554000px;width:227.222800px;height:23.334000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[361,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:307.223000px;bottom:652.222000px;width:253.890000px;height:60.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[361,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:331.112000px;bottom:431.110000px;width:187.223000px;height:35.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[378,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:309.445000px;bottom:418.332000px;width:156.112000px;height:11.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[379,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:393.332000px;width:133.889000px;height:23.889000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[381,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:331.112000px;bottom:379.999000px;width:81.667000px;height:10.555000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[386,"FitH",788]'><div class="d m2" 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style="border-style:none;position:absolute;left:47.777900px;bottom:229.998000px;width:228.889100px;height:22.223000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[354,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:68.889100px;bottom:203.887000px;width:230.555900px;height:24.445000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[354,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:47.222400px;bottom:178.887000px;width:231.667600px;height:23.889000px;background-color:rgba(255,255,255,0.000001);"></div></a></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y18d w6 h20" alt="" src="https://files.passeidireto.com/2c2887a1-7bea-4249-b4f3-c9d0fcc5ebbe/bga.png"><div class="t m0 x0 h1d y8f ffe fs6 fc0 sc0 lscc">x<span class="ffd ls43 ws1"> </span><span class="ff8 ls8c wsd4">T<span class="_3 blank"></span>abela dos Conteúdos</span></div><div class="t m0 x0 h13 y18e ff8 fs4 fc0 sc0 ls85 ws166">Regulação transcricional da expr<span class="_0 blank"></span>essão</div><div class="t m0 x0 h13 y18f ff8 fs4 fc0 sc0 ls72 ws167">gênica: Fator<span class="_0 blank"></span>es de transcrição</div><div class="t m0 x0 h13 y190 ff8 fs4 fc0 sc0 ls85 ws168">e a ativação de pr<span class="_0 blank"></span>omotor<span class="_0 blank"></span>es</div><div class="t m0 x0 h13 y191 ff8 fs4 fc0 sc0 lsdb ws169">específicos 391</div><div class="t m0 x0 h14 y192 ff8 fsa fc0 sc0 ls62 ws16a">Éxons e Íntr<span class="_4 blank"></span>ons 392</div><div class="t m0 x0 h14 y193 ff8 fsa fc0 sc0 ls4d ws16b">Estrutura e função do pr<span class="_4 blank"></span>omotor 394</div><div class="t m0 x13 h15 y194 ff9 fsb fc0 sc0 ls44 ws16c">Estrutura do promotor 396</div><div class="t m0 x13 h15 y195 ff9 fsb fc0 sc0 ls4a ws16d">Função do promotor 397</div><div class="t m0 x15 h14 y196 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y197 ffb fsc fc0 sc0 ls75 ws16e">RNA polimerase e os fatores trans-reguladores</div><div class="t m1 x14 h17 y198 ffb fsc fc0 sc0 lsdc ws16f">no promotor 399</div><div class="t m0 x0 h14 y199 ff8 fsa fc0 sc0 ls47 ws170">Estrutura e função dos intensificador<span class="_4 blank"></span>es 402</div><div class="t m0 x13 h15 y19a ff9 fsb fc0 sc0 ls44 ws9f">Necessidade de intensificadores 402</div><div class="t m0 x13 h15 y19b ff9 fsb fc0 sc0 ls44 wsb7">Função do intensificador: Modelos temporais e</div><div class="t m0 x14 h15 y19c ff9 fsb fc0 sc0 ls44 ws171">espaciais de transcrição 403</div><div class="t m0 x0 h14 y19d ff8 fsa fc0 sc0 lsb5 ws172">Fator<span class="_4 blank"></span>es de transcrição: Os trans-r<span class="_0 blank"></span>eguladores dos</div><div class="t m0 x14 h14 y19e ff8 fsa fc0 sc0 ls42 ws173">pr<span class="_4 blank"></span>omotor<span class="_0 blank"></span>es e dos intensificador<span class="_4 blank"></span>es 404</div><div class="t m0 x13 h15 y19f ff9 fsb fc0 sc0 ls44 ws174">Proteínas de homeodomínio 405</div><div class="t m0 x13 h15 y1a0 ff9 fsb fc0 sc0 ls4e ws96">Os fatores de transcrição POU 406</div><div class="t m0 x15 h14 y1a1 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y1a2 ffb fsc fc0 sc0 ls53 ws175">Regulação da transcrição dos genes de cadeia</div><div class="t m1 x14 h17 y1a3 ffb fsc fc0 sc0 ls53 ws176">leve das imunoglobulinas 409</div><div class="t m0 x13 h15 y1a4 ff9 fsb fc0 sc0 lsc9 ws177">F<span class="_0 blank"></span>atores de transcr<span class="_5 blank"> </span>ição básicos do tipo hélice-alça-</div><div class="t m0 x14 h15 y1a5 ff9 fsb fc0 sc0 ls4a ws178">hélice 415</div><div class="t m0 x15 h14 y1a6 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y1a7 ffb fsc fc0 sc0 ls99 ws179">Regulando as proteínas bHLH miogênicas:</div><div class="t m1 x14 h17 y1a8 ffb fsc fc0 sc0 ls99 ws17a">Governando a troca entre proliferação e</div><div class="t m1 x14 h17 y1a9 ffb fsc fc0 sc0 ls54 ws17b">diferenciação de células musculares 416</div><div class="t m0 x13 h15 y1aa ff9 fsb fc0 sc0 lsa9 ws17c">F<span class="_0 blank"></span>atores de transcrição do zíper básico da leucina 416</div><div class="t m0 x15 h14 y47 ffa fs8 fc2 sc0 ls45">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x13 h17 y1ab ffb fsc fc0 sc0 ls99 ws17d">Armadilhas do intensificador: natural e</div><div class="t m1 x14 h17 y1ac ffb fsc fc0 sc0 ls53 ws17e">experimental 418</div><div class="t m0 x13 h15 y1ad ff9 fsb fc0 sc0 ls48 ws102">F<span class="_0 blank"></span>atores de <span class="_4 blank"></span>T<span class="_2 blank"></span>ranscrição Dedo de Zinco 420</div><div class="t m0 x13 h15 y1ae ff9 fsb fc0 sc0 ls48 ws17f">Receptores Nucleares de Hormônios e Seus</div><div class="t m0 x14 h15 y1af ff9 fsb fc0 sc0 ls48 ws180">Elementos Responsivos a Hormônios 420</div><div class="t m0 x0 h14 y1b0 ff8 fsa fc0 sc0 ls62 ws181">Pr<span class="_0 blank"></span>oteínas que dobram o DNA 423</div><div class="t m0 x0 h14 y1b1 ff8 fsa fc0 sc0 ls56 ws74">Ativação dependente de contexto ou silenciamento 423</div><div class="t m0 x0 h14 y1b2 ff8 fsa fc0 sc0 ls47 ws182">Regulação da atividade do fator de transcrição 425</div><div class="t m0 x0 h13 y1b3 ff8 fs4 fc0 sc0 ls85 ws183">Regulação transcricional da</div><div class="t m0 x0 h13 y1b4 ff8 fs4 fc0 sc0 ls50 ws184">expr<span class="_0 blank"></span>essão gênica: A<span class="_0 blank"></span> ativação da</div><div class="t m0 x0 h13 y1b5 ff8 fs4 fc0 sc0 ls50 ws185">cr<span class="_0 blank"></span>omatina 431</div><div class="t m0 x0 h14 y1b6 ff8 fsa fc0 sc0 ls47 ws186">Nucleossomos e a ativação da cr<span class="_4 blank"></span>omatina r<span class="_0 blank"></span>eprimida 431</div><div class="t m0 x13 h15 y1b7 ff9 fsb fc0 sc0 ls44 ws154">Acessibilidade a fatores trans-reguladores 432</div><div class="t m0 x13 h15 y1b8 ff9 fsb fc0 sc0 ls48 ws187">Sítios hipersensíveis à DNAase I 434</div><div class="t m0 x0 h18 y1b9 ffc fs9 fc2 sc0 lsdd ws5e">P<span class="_7 blank"></span>ARTE III<span class="ff8 fsd fc0 lsde ws5f"> Mecanismo da Difer<span class="_0 blank"></span>enciação Celular</span></div><div class="t m0 x1e h1b y1ba ffc fse fc0 sc0 lsdf">10</div><div class="t m0 x18 h15 y1bb ff9 fsb fc0 sc0 ls81 ws149">Ruptura e reorganização de nucleossomos: o papel</div><div class="t m0 x19 h15 y1bc ff9 fsb fc0 sc0 ls44 ws188">dos complexos de ruptura 436</div><div class="t m0 x18 h15 y1bd ff9 fsb fc0 sc0 ls81 ws149">Ruptura e reorganização de nucleossomos: o papel</div><div class="t m0 x19 h15 y1be ff9 fsb fc0 sc0 ls81 ws189">da competição de histonas 437</div><div class="t m0 x2 h14 y1bf ff8 fsa fc0 sc0 ls47 ws18a">Regiões de contr<span class="_0 blank"></span>ole de loco: transcrição do gene da</div><div class="t m0 x19 h14 y1c0 ff8 fsa fc0 sc0 ls4d ws18b">globina 437</div><div class="t m0 x1a h14 y1c1 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y1c2 ffb fsc fc0 sc0 ls75 ws18c">T<span class="_3 blank"></span>rocas no gene de globina 440</div><div class="t m0 x2 h14 y1c3 ff8 fsa fc0 sc0 lsb5 ws18d">Metilação de DNA e atividade gênica 442</div><div class="t m0 x18 h15 y1c4 ff9 fsb fc0 sc0 ls48 ws18e">Correlações entre metilação do promotor e</div><div class="t m0 x19 h15 y1c5 ff9 fsb fc0 sc0 ls4a ws5c">inatividade gênica 442</div><div class="t m0 x18 h15 y1c6 ff9 fsb fc0 sc0 ls4e ws96">Metilação e a manutenção dos padrões de</div><div class="t m0 x19 h15 y1c7 ff9 fsb fc0 sc0 lsc9 ws18f">transcrição 443</div><div class="t m0 x1a h14 y1c8 ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y1c9 ffb fsc fc0 sc0 ls54 ws190">Metilação e impressão gênica 444</div><div class="t m0 x2 h14 y1ca ff8 fsa fc0 sc0 ls5d ws191">Compensação de dosagem do cr<span class="_0 blank"></span>omossomo X de</div><div class="t m0 x19 h14 y1cb ff8 fsa fc0 sc0 lscd ws192">mamífer<span class="_0 blank"></span>os 446</div><div class="t m0 x1a h14 y1cc ffa fs8 fc2 sc0 ls4b">Q<span class="ff8 fsa fc0 ls56 ws55">Informações adicionais & Especulações</span></div><div class="t m1 x18 h17 y1cd ffb fsc fc0 sc0 lse0 ws193">O mecanismo de inativação do cromossomo X <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_8 blank"> </span>449</div><div class="t m0 x2 h14 y1ce ff8 fsa fc0 sc0 ls4d ws194">Associação do DNA ativo com a matriz nuclear 451</div><div class="t m0 x18 h15 y1cf ff9 fsb fc0 sc0 lsad ws135">Ligação da cromatina ativa a uma matriz nuclear 451</div><div class="t m0 x18 h15 y1d0 ff9 fsb fc0 sc0 ls63 ws195">T<span class="_2 blank"></span>opoisomerases e a transcrição gênica 453</div><div class="t m0 x18 h15 y1d1 ff9 fsb fc0 sc0 ls4a ws196">Isoladores e domínios 454</div><div class="t m0 x18 h15 y1d2 ff9 fsb fc0 sc0 ls48 ws102">Resumo 455</div><div class="t m0 x2 h13 y1d3 ff8 fs4 fc0 sc0 ls85 ws197">Contr<span class="_0 blank"></span>ole do desenvolvimento pelo</div><div class="t m0 x2 h13 y1d4 ff8 fs4 fc0 sc0 lse1 ws198">pr<span class="_0 blank"></span>ocessamento e tradução</div><div class="t m0 x2 h13 y1d5 ff8 fs4 fc0 sc0 ls72 wse8">difer<span class="_0 blank"></span>encial do RNA 461</div><div class="t m0 x2 h21 y1d6 ffd fsa fc0 sc0 lsce">C<span class="fs10 lscf ws15c">ONTROLE</span><span class="lsd0 ws1"> </span><span class="fs10 lsa4 wscd">DO</span><span class="lse2 ws1"> D<span class="_2 blank"></span><span class="fs10 lsb8 ws125">ESENVOL<span class="_3 blank"></span>VIMENTO<span class="fsa lsd0 ws1"> </span><span class="lsd1 ws15d">PELO<span class="fsa lse3 ws1"> P<span class="_2 blank"></span><span class="fs10 lsd2 ws15e">ROCESSAMENTO</span></span></span></span></span></div><div class="t m0 x19 h14 y1d7 ffd fsa fc0 sc0 lsd3">D<span class="fs10 lsd4 ws15f">IFERENCIAL</span><span class="ls8f ws1"> </span><span class="fs10 ls86 ws160">DE</span><span class="lsd5 ws199"> RNA</span><span class="ff8 lsd6 ws1"> </span><span class="ls4d">461</span></div><div class="t m0 x2 h14 y1d8 ff8 fsa fc0 sc0 lsd7 ws19a">Contr<span class="_0 blank"></span>ole do desenvolvimento precoce pela seleção de</div><div class="t m0 x19 h14 y1d9 ff8 fsa fc0 sc0 ls62 ws9c">RNA nuclear 462</div><div class="t m0 x2 h14 y1da ff8 fsa fc0 sc0 ls62 ws19b">Os mecanismos de emenda de RNA: Spliceosomes 465</div><div class="t m0 x2 h14 y1db ff8 fsa fc0 sc0 ls42 ws147">Emenda alternativa do RNA: Criando pr<span class="_0 blank"></span>oteínas</div><div class="t m0 x19 h14 y1dc ff8 fsa fc0 sc0 ls5d ws19c">alternativas a partir do mesmo gene 466</div><div class="t m0 x18 h15 y1dd ff9 fsb fc0 sc0 ls44 ws129">Um gene, Muitas Proteínas Relacionadas 466</div><div class="t m0 x18 h15 y1de ff9 fsb fc0 sc0 lsc4 ws82">Processamento Alternativo de RNA e</div><div class="t m0 x19 h15 y1df ff9 fsb fc0 sc0 ls63 ws19d">Determinação Sexual em Drosophila 468</div><div class="t m0 x18 h15 y1e0 ff9 fsb fc0 sc0 ls63 ws57">Uso Disseminado do Processamento de RNA para</div><div class="t m0 x19 h15 y1e1 ff9 fsb fc0 sc0 ls4e ws69">o Controle da Expressão Gênica 471</div><div class="t m0 x2 h21 y1e2 ffd fsa fc0 sc0 lsce">R<span class="fs10 lse4 ws161">EGULAÇÃO</span><span class="lsd8 ws1"> </span><span class="fs10 lse5 ws162">DA </span><span class="lse6 ws1"> T<span class="_3 blank"></span><span class="fs10 lsd9 ws163">RADUÇÃO<span class="fsa lsd8 ws1"> </span><span class="lse7 ws164">DOS<span class="fsa lse8 ws1"> P<span class="_3 blank"></span><span class="fs10 lse9">ROCESSOS</span></span></span></span></span></div><div class="t m0 x19 h14 y1e3 ffd fsa fc0 sc0 lsd3">D<span class="fs10 lsea ws165">ESENVOL<span class="_0 blank"></span>VIMENT<span class="_0 blank"></span>AIS<span class="ff8 fsa lsda ws1"> <span class="ffd ls4d">471</span></span></span></div><div class="t m0 x2 h14 y1e4 ff8 fsa fc0 sc0 ls4d ws62">Mecanismos da tradução eucariótica 472</div><div class="t m0 x2 h14 y1e5 ff8 fsa fc0 sc0 ls56 ws19e">Contr<span class="_0 blank"></span>ole da síntese protéica pela longevidade difer<span class="_0 blank"></span>encial</div><div class="t m0 x19 h14 y1e6 ff8 fsa fc0 sc0 ls52 ws19f">do mRNA 474</div><div class="t m0 x18 h15 y55 ff9 fsb fc0 sc0 ls4e ws1a0">Degradação Seletiva de mRNAs 475</div><div class="t m0 x2 h14 y1e7 ff8 fsa fc0 sc0 ls42 ws1a1">Contr<span class="_0 blank"></span>ole da tradução de mensagens do oócito 476</div><div class="t m0 x1f h1b y1e8 ffc fse fc0 sc0 lseb">11</div><div 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style="border-style:none;position:absolute;left:49.444600px;bottom:571.666000px;width:166.667400px;height:10.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[416,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.000200px;bottom:558.333000px;width:128.889800px;height:10.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[417,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.555800px;bottom:544.999000px;width:121.111200px;height:11.112000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[419,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.000200px;bottom:507.777000px;width:225.000800px;height:36.111000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[422,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:50.000200px;bottom:494.999000px;width:200.000800px;height:10.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[422,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.000200px;bottom:482.221000px;width:176.111800px;height:10.556000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[423,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:70.555800px;bottom:457.221000px;width:210.000200px;height:23.334000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[424,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:50.000200px;bottom:431.110000px;width:216.111800px;height:25.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[425,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:420.554000px;width:157.222700px;height:10.001000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[426,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:71.111300px;bottom:406.666000px;width:168.333700px;height:11.666000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[456,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:656.111000px;width:230.000000px;height:23.333000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[457,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.557000px;bottom:629.444000px;width:228.889000px;height:24.445000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[457,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:310.001000px;bottom:605.000000px;width:223.890000px;height:22.777000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[460,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:331.112000px;bottom:579.444000px;width:176.112000px;height:23.889000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[462,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:308.890000px;bottom:568.333000px;width:193.889000px;height:10.000000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[462,"FitH",788]'><div class="d m2" style="border-style:none;position:absolute;left:330.001000px;bottom:542.222000px;width:191.667000px;height:23.333000px;background-color:rgba(255,255,255,0.000001);"></div></a><a class="l" data-dest-detail='[463,"FitH",788]'><div class="d m2" 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