hipotireoidismo
9 pág.

hipotireoidismo


DisciplinaNutrição19.573 materiais159.777 seguidores
Pré-visualização5 páginas
Interciência 
 & Sociedade36
HIPOTIREOIDISMO E HIPERTIREOIDISMO \u2013 UMA BREVE REVISÃO 
SOBRE AS DISFUNÇÕES TIREOIDIANAS
2/,9(,5$\ufffd\ufffd9DQHVVD
)DFXOGDGH\ufffd0XQLFLSDO\ufffd3URIHVVRU\ufffd)UDQFR\ufffd0RQWRUR\ufffd\ufffd)03)0\ufffd
YDQ\ufffdQXWUL\ufffd\ufffd\ufffd\ufffd#KRWPDLO\ufffdFRP
MALDONADO, Rafael Resende 
)DFXOGDGH\ufffd0XQLFLSDO\ufffd3URIHVVRU\ufffd)UDQFR\ufffd0RQWRUR\ufffd\ufffd)03)0\ufffd
UDWDIWD#\DKRR\ufffdFRP\ufffdEU\ufffd
RESUMO\ufffd\ufffd+LSRWLUHRLGLVPR\ufffdH\ufffdKLSHUWLUHRLGLVPR\ufffdVmR\ufffdGLVIXQo}HV\ufffdGD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffdTXH\ufffdFDXVDP\ufffdGLYHUVDV\ufffd
DOWHUDo}HV\ufffdQR\ufffdRUJDQLVPR\ufffdKXPDQR\ufffd\ufffd(VWH\ufffdWUDEDOKR\ufffdWHYH\ufffdFRPR\ufffdREMHWLYR\ufffdUHDOL]DU\ufffdXPD\ufffdUHYLVmR\ufffdGD\ufffdOLWHUDWXUD\ufffd
VREUH\ufffdDVSHFWRV\ufffdJHUDLV\ufffdGHVVDV\ufffdGXDV\ufffdGLVIXQo}HV\ufffd\ufffdWDLV\ufffdFRPR\ufffdWLSRV\ufffd\ufffdGH¿QLo}HV\ufffd\ufffdVLQWRPDV\ufffd\ufffdHIHLWRV\ufffdVREUH\ufffdR\ufffd
RUJDQLVPR\ufffd\ufffdGLDJQyVWLFRV\ufffdH\ufffd WUDWDPHQWR\ufffd\ufffd)RL\ufffd UHDOL]DGD\ufffdXPD\ufffdEXVFD\ufffdGH\ufffdDUWLJRV\ufffdFLHQWt¿FRV\ufffdHP\ufffdGLIHUHQWHV\ufffd
EDVHV\ufffdGH\ufffdGDGRV\ufffdFRP\ufffd WHUPRV\ufffdDVVRFLDGRV\ufffdD\ufffdKLSRWLUHRLGLVPR\ufffdH\ufffdKLSHUWLUHRLGLVPR\ufffd\ufffd([LVWH\ufffdYDVWD\ufffd OLWHUDWXUD\ufffd
VREUH\ufffdR\ufffdDVVXQWR\ufffd\ufffdLQGLFDQGR\ufffdTXH\ufffdHVWDV\ufffdGLVIXQo}HV\ufffdSRGHP\ufffdRFRUUHU\ufffdGH\ufffdGLIHUHQWHV\ufffdIRUPDV\ufffd\ufffdFRP\ufffdLPSDFWRV\ufffd
QR\ufffdVLVWHPD\ufffdFDUGLRYDVFXODU\ufffd\ufffdSXOPRQDU\ufffd\ufffdFpUHEUR\ufffdH\ufffdWDPEpP\ufffdGXUDQWH\ufffdD\ufffdJHVWDomR\ufffd\ufffd2\ufffdGLDJQyVWLFR\ufffdp\ufffdIHLWR\ufffdDWUD\ufffd
YpV\ufffdGD\ufffdGRVDJHP\ufffdGRV\ufffdKRUP{QLRV\ufffd76+\ufffd\ufffd7\ufffd\ufffdH\ufffd7\ufffd\ufffd\ufffd4XDQWR\ufffdj\ufffdTXHVWmR\ufffdQXWULFLRQDO\ufffd\ufffdSRXFRV\ufffdWUDEDOKRV\ufffdIRUDP\ufffd
HQFRQWUDGRV\ufffdVREUH\ufffdR\ufffdSDSHO\ufffdGD\ufffdDOLPHQWDomR\ufffdWDQWR\ufffdQR\ufffdVXUJLPHQWR\ufffd\ufffdFRPR\ufffdQR\ufffdFRQWUROH\ufffdGHVWDV\ufffdGLVIXQo}HV\ufffd\ufffd
PALAVRAS-CHAVE\ufffd\ufffd+LSRWHLURLGLVPR\ufffd\ufffdKLSHUWLUHRLGLVPR\ufffd\ufffdGRHQoD\ufffdGH\ufffd*UDYHV\ufffd\ufffdVLVWHPD\ufffdFDUGLRYDVFXODU\ufffd\ufffdDWL\ufffd
YLGDGH\ufffdItVLFD\ufffd
ABSTRACT: +\SRWK\URLGLVP\ufffdDQG\ufffdK\SHUWK\URLGLVP\ufffdDUH\ufffdGLVRUGHUV\ufffdRI\ufffdWK\URLG\ufffdJODQG\ufffdZKLFK\ufffdFDXVH\ufffdVHYHUDO\ufffd
FKDQJHV\ufffdLQ\ufffdWKH\ufffdKXPDQ\ufffdERG\\ufffd\ufffd7KLV\ufffdVWXG\\ufffdDLPHG\ufffdWR\ufffdUHYLHZ\ufffdWKH\ufffdOLWHUDWXUH\ufffdRQ\ufffdJHQHUDO\ufffdDVSHFWV\ufffdRI\ufffdWKHVH\ufffdWZR\ufffdGL-
VRUGHUV\ufffd\ufffdVXFK\ufffdDV\ufffdW\SHV\ufffd\ufffdGH¿QLWLRQV\ufffd\ufffdV\PSWRPV\ufffd\ufffdHIIHFWV\ufffdRQ\ufffdWKH\ufffdERG\\ufffd\ufffdGLDJQRVLV\ufffdDQG\ufffdWUHDWPHQW\ufffd\ufffd$\ufffdVHDUFK\ufffdRI\ufffd
VFLHQWL¿F\ufffdDUWLFOHV\ufffdLQ\ufffdGLIIHUHQW\ufffdGDWDEDVHV\ufffdZLWK\ufffdDVVRFLDWHG\ufffdK\SRWK\URLGLVP\ufffdDQG\ufffdK\SHUWK\URLGLVP\ufffdWHUPV\ufffdZDV\ufffd
SHUIRUPHG\ufffd\ufffd7KHUH\ufffdLV\ufffdYDVW\ufffdOLWHUDWXUH\ufffdRQ\ufffdWKH\ufffdVXEMHFW\ufffd\ufffdLQGLFDWLQJ\ufffdWKDW\ufffdWKHVH\ufffdGLVRUGHUV\ufffdFDQ\ufffdRFFXU\ufffdLQ\ufffdGLIIHUHQW\ufffd
ZD\V\ufffd\ufffdZLWK\ufffdLPSDFWV\ufffdRQ\ufffdWKH\ufffdFDUGLRYDVFXODU\ufffdV\VWHP\ufffd\ufffdOXQJ\ufffd\ufffdEUDLQ\ufffd\ufffdDQG\ufffdDOVR\ufffdGXULQJ\ufffdSUHJQDQF\\ufffd\ufffd7KH\ufffdGLDJQRVLV\ufffd
LV\ufffdPDGH\ufffdE\\ufffdWKH\ufffdGRVDJH\ufffdRI\ufffdWKH\ufffdKRUPRQHV\ufffd76+\ufffd\ufffd7\ufffd\ufffdDQG\ufffd7\ufffd\ufffd\ufffd5HJDUGLQJ\ufffdQXWULWLRQDO\ufffdLVVXH\ufffd\ufffdIHZ\ufffdVWXGLHV\ufffdZHUH\ufffd
IRXQG\ufffdDERXW\ufffdWKH\ufffdUROH\ufffdRI\ufffdIRRG\ufffdERWK\ufffdLQ\ufffdDSSHDUDQFH\ufffdDV\ufffdLQ\ufffdFRQWUROOLQJ\ufffdWKHVH\ufffdGLVRUGHUV\ufffd
KEYWORDS: +\SRWK\URLGLVP\ufffd\ufffdK\SHUWK\URLGLVP\ufffd\ufffd*UDYHV\ufffdGLVHDVH\ufffd\ufffdFDUGLRYDVFXODU\ufffdV\VWHP\ufffd\ufffdSK\VLFDO\ufffdDF-
WLYLW\\ufffd
1. INTRODUÇÃO
+LSRWLUHRLGLVPR\ufffd H\ufffd KLSHUWLUHRLGLVPR 
VmR\ufffd GXDV\ufffd GLVIXQo}HV\ufffd GD\ufffd JOkQGXOD\ufffd WLUHRLGH\ufffd
TXH\ufffd FDXVDP\ufffd XPD\ufffd VpULH\ufffd GH\ufffd DOWHUDo}HV\ufffd QR\ufffd
RUJDQLVPR\ufffd KXPDQR\ufffd\ufffd 2\ufffd KLSRWLUHRLGLVPR\ufffd p\ufffd
GH¿QLGR\ufffdFRPR\ufffdXP\ufffdHVWDGR\ufffdFOtQLFR\ufffdUHVXOWDQWH\ufffd
GH\ufffdTXDQWLGDGH\ufffd LQVX¿FLHQWH\ufffdRX\ufffdDXVrQFLD\ufffdGH\ufffd
KRUP{QLRV\ufffdFLUFXODQWHV\ufffdGD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffd\ufffd
GHQRPLQDGRV\ufffd 7\ufffd\ufffd \ufffdWLUR[LQD\ufffd\ufffd H\ufffd 7\ufffd\ufffd \ufffdWUL\ufffdLRGR\ufffd
WLURQLQD\ufffd\ufffd\ufffd SDUD\ufffd VXSULU\ufffd XPD\ufffd IXQomR\ufffd RUJkQLFD\ufffd
QRUPDO\ufffd\ufffd (QTXDQWR\ufffd TXH\ufffd R\ufffd KLSHUWLUHRLGLVPR\ufffd
FRQVLVWH\ufffd HP\ufffd XP\ufffd HVWDGR\ufffd KLSHUPHWDEyOLFR\ufffd
FDXVDGR\ufffdSHOR\ufffdDXPHQWR\ufffdQD\ufffd IXQomR\ufffdGD\ufffdJOkQ\ufffd
dula tireoide e, consequente, aumento dos 
QtYHLV\ufffdFLUFXODQWHV\ufffdGRV\ufffdKRUP{QLRV\ufffd7\ufffd\ufffdH\ufffd7\ufffd\ufffdOL\ufffd
YUHV\ufffd\ufffd$V\ufffdFDXVDV\ufffdPDLV\ufffdFRPXQV\ufffdVmR\ufffdKLSHUSOD\ufffd
VLD\ufffdGLIXVD\ufffdGD\ufffdWLUHRLGH\ufffdDVVRFLDGD\ufffdj\ufffdGRHQoD\ufffdGH\ufffd
*UDYHV\ufffd\ufffdEyFLR\ufffdPXOWLQRGXODU\ufffdKLSHUIXQFLRQDQ\ufffd
WH\ufffdH\ufffdDGHQRPD\ufffdKLSHUIXQFLRQDQWH\ufffdGD\ufffdWLUHRLGH\ufffd\ufffd
2. HIPOTIREOIDISMO
\ufffd +LSRWLUHRLGLVPR\ufffd p\ufffd GH¿QLGR\ufffd
FRPR\ufffdXP\ufffdHVWDGR\ufffdFOtQLFR\ufffdUHVXOWDQWH\ufffdGH\ufffdTXDQ\ufffd
WLGDGH\ufffd LQVX¿FLHQWH\ufffd RX\ufffd DXVrQFLD\ufffd GH\ufffd KRUP{\ufffd
QLRV\ufffdFLUFXODQWHV\ufffdGD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffd\ufffdGHQR\ufffd
PLQDGRV\ufffd7\ufffd\ufffd\ufffdWLUR[LQD\ufffd\ufffdH\ufffd7\ufffd\ufffd\ufffdWUL\ufffdLRGRWLURQLQD\ufffd\ufffd\ufffd
SDUD\ufffd VXSULU\ufffd XPD\ufffd IXQomR\ufffd RUJkQLFD\ufffd QRUPDO\ufffd\ufffd
$\ufffd IRUPD\ufffd PDLV\ufffd SUHYDOHQWH\ufffd p\ufffd D\ufffd GRHQoD\ufffd WL\ufffd
UHRLGLDQD\ufffd SULPiULD\ufffd\ufffd GHQRPLQDGD\ufffd GH\ufffd KLSRWL\ufffd
UHRLGLVPR\ufffd SULPiULR\ufffd\ufffd TXH\ufffd p\ufffd XPD\ufffd GH¿FLrQFLD\ufffd
KRUPRQDO\ufffd FDXVDGD\ufffd GHYLGR\ufffd j\ufffd LQFDSDFLGDGH\ufffd\ufffd
SDUFLDO\ufffdRX\ufffdWRWDO\ufffd\ufffdGD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffdGH\ufffdSUR\ufffd
Interciência 
 & Sociedade37
GX]LU\ufffd RV\ufffd KRUP{QLRV\ufffd WLUHRLGLDQRV\ufffd \ufffd0h//(5\ufffd
HW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd1R\ufffdHQWDQWR\ufffd\ufffdR\ufffdKLSRWLUHRLGLVPR\ufffd
SRGH\ufffdVH\ufffdDSUHVHQWDU\ufffdGH\ufffdRXWUDV\ufffdPDQHLUDV\ufffd\ufffdWDLV\ufffd
FRPR\ufffd KLSRWLUHRLGLVPR\ufffd FRQJrQLWR\ufffd\ufffd FHQWUDO\ufffd H\ufffd
VXEFOtQLFR\ufffd\ufffd\ufffd
2\ufffd KLSRWLUHRLGLVPR\ufffd FRQJrQLWR\ufffd \ufffd+&\ufffd\ufffd
p\ufffdD\ufffd FDXVD\ufffdPDLV\ufffd FRPXP\ufffdGH\ufffd UHWDUGR\ufffdPHQWDO\ufffd
SDVVtYHO\ufffd GH\ufffd SUHYHQomR\ufffd\ufffd (OH\ufffd UHVXOWD\ufffd GD\ufffd GH\ufffd
¿FLrQFLD\ufffd GRV\ufffd KRUP{QLRV\ufffd WLUHRLGLDQRV\ufffd\ufffd IXQ\ufffd
damentais na organogênese do sistema 
QHUYRVR\ufffd FHQWUDO\ufffd DWp\ufffd RV\ufffd GRLV\ufffd DQRV\ufffd GH\ufffd YLGD\ufffd\ufffd
quando estimulam o crescimento dos den\ufffd
GULWRV\ufffdH\ufffdD[{QLRV\ufffd\ufffdDOpP\ufffdGH\ufffdFRQWULEXtUHP\ufffdSDUD\ufffd
D\ufffd IRUPDomR\ufffdGR\ufffdFyUWH[\ufffdFHUHEUDO\ufffdDQWHULRU\ufffd\ufffdKL\ufffd
SRFDPSR\ufffd\ufffd FyUWH[\ufffd DXGLWLYR\ufffd H\ufffd FHUHEHOR\ufffd \ufffd%(\ufffd
1(9,'(6\ufffdHW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd
\ufffd *HUDOPHQWH\ufffd HVWH\ufffd WLSR\ufffd GH\ufffd KLSHUWL\ufffd
UHRLGLVPR\ufffdp\ufffdGHFRUUHQWH\ufffdGH\ufffdGHIHLWRV\ufffdQD\ufffd IRU\ufffd
mação glandular durante a embriogênese e 
HYLGrQFLDV\ufffdVXJHUHP\ufffdTXH\ufffdPXWDo}HV\ufffdQRV\ufffd ID\ufffd
WRUHV\ufffdGH\ufffdWUDQVFULomR\ufffd\ufffd77)\ufffd\ufffd\ufffd77)\ufffd\ufffdH\ufffd3$;\ufffd\ufffd\ufffd\ufffd
PXLWDV\ufffdYH]HV\ufffdVmR\ufffdRV\ufffdUHVSRQViYHLV\ufffdSHOD\ufffdGR\ufffd
HQoD\ufffd\ufffd$\ufffdIDOWD\ufffdGH\ufffdHVWtPXOR\ufffdGR\ufffd76+\ufffd\ufffdKRUP{QLR\ufffd
HVWLPXODGRU\ufffdGD\ufffdWLUHRLGH\ufffd\ufffdQD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffd
OHYD\ufffdD\ufffdRFRUUrQFLD\ufffdGD\ufffdGRHQoD\ufffd\ufffdPRWLYDGD\ufffdSRU\ufffd
Pi\ufffdIRUPDomR\ufffdRX\ufffdGLVIXQomR\ufffdKLSRIiVLFD\ufffdRX\ufffdKL\ufffd
SRWDOkPLFD\ufffd\ufffd2FRUUH\ufffdJHUDOPHQWH\ufffdSRU\ufffdGLV\ufffdKRU\ufffd
PRJrQHVH\ufffdGD\ufffdJOkQGXOD\ufffdWLUHRLGH\ufffd\ufffdSRU\ufffdGHIHLWR\ufffd
QR\ufffd WUDQVSRUWDGRU\ufffd GH\ufffd LRGHWR\ufffd QD\ufffd PHPEUDQD\ufffd
EDVDO\ufffd H\ufffdRX\ufffd DSLFDO\ufffd\ufffd GHIHLWRV\ufffd QD\ufffd VtQWHVH\ufffd GD\ufffd
7*\ufffdRX\ufffdGHIHLWRV\ufffdQD\ufffdRUJDQL¿FDomR\ufffdGR\ufffd LRGHWR\ufffd
\ufffd3(5521(\ufffdHW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd$\ufffdELRVVtQWHVH\ufffdGRV\ufffd
KRUP{QLRV\ufffd GD\ufffd WLUHRLGH\ufffd WHP\ufffdQD\ufffd HQ]LPD\ufffd WLUH\ufffd
RSHUR[LGDVH\ufffd \ufffd732\ufffd\ufffd XPD\ufffd IXQomR\ufffd FKDYH\ufffd GH\ufffd
FDWDOLVDU\ufffdLPSRUWDQWHV\ufffdUHDo}HV\ufffd\ufffd0XWDo}HV\ufffdQR\ufffd
gene relacionado a esta enzima são consi\ufffd
GHUDGRV\ufffdD\ufffdSULQFLSDO\ufffdFDXVD\ufffdGH\ufffd+&\ufffdSRU\ufffdGLVRU\ufffd
PRQRJrQHVH\ufffd\ufffd628=$\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd 
'RHQoDV\ufffd QHXURSVLTXLiWULFDV\ufffd SR\ufffd
GHP\ufffdDSUHVHQWDU\ufffdP~OWLSORV\ufffdHQIRTXHV\ufffd\ufffdGHQWUH\ufffd
HOHV\ufffdUHODomR\ufffdFRP\ufffdRV\ufffdKRUP{QLRV\ufffdGD\ufffdWLUHRLGH\ufffd\ufffd\ufffd
Pesquisa realizada com um menino de cin\ufffd
FR\ufffdDQRV\ufffdGH\ufffdLGDGH\ufffdFRP\ufffdKLSRWLUHRLGLVPR\ufffdFRQ\ufffd
JrQLWR\ufffdDVVRFLDGR\ufffdD\ufffdSUREOHPDV\ufffdGR\ufffdGHVHQYRO\ufffd
YLPHQWR\ufffdGH\ufffdRUGHP\ufffdLQVWUXPHQWDO\ufffdH\ufffdHVWUXWXUDO\ufffd\ufffd
UHODWD\ufffdUHWDUGR\ufffdQR\ufffdGHVHQYROYLPHQWR\ufffdSVLFRPR\ufffd
WRU\ufffd\ufffd SULQFLSDOPHQWH\ufffd QD\ufffd IDOD\ufffd\ufffd KLSRWRQLD\ufffdPXV\ufffd
FXODU\ufffdH\ufffdKLSRDFXVLD\ufffdELODWHUDO\ufffd\ufffd$\ufffdHYROXomR\ufffdGR\ufffd
FDVR\ufffdUHODWDGR\ufffdDSRQWRX\ufffdPHOKRUD\ufffdGD\ufffdVLQWRPD\ufffd
WRORJLD\ufffd DVVLP\ufffd TXH\ufffd VH\ufffd REWHYH\ufffd FRQWUROH\ufffd GRV\ufffd
KRUP{QLRV\ufffd WLUHRLGRV\ufffd \ufffd%UDJDWWL\ufffd:LQFNOHU\ufffd 	\ufffd
5RWWD\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd
3UREOHPDV\ufffd IRQRXGLROyJLFRV\ufffd WDP\ufffd
EpP\ufffdVmR\ufffd UHODWDGRV\ufffd HP\ufffd FULDQoDV\ufffd TXH\ufffd DSUH\ufffd
VHQWDP\ufffdKLSRWLUHRLGLVPR\ufffdFRQJrQLWR\ufffd\ufffd7UDEDOKR\ufffd
UHDOL]DGR\ufffd FRP\ufffd FULDQoDV\ufffd GH\ufffd \ufffd\ufffd D\ufffd \ufffd\ufffd DQRV\ufffd QR\ufffd
$FUH\ufffdH\ufffdHP\ufffd5RQG{QLD\ufffd\ufffdDSRQWDRX\ufffdSDUD\ufffdDWUDVR\ufffd
QR\ufffdLQtFLR\ufffdGD\ufffdOLQJXDJHP\ufffdRUDO\ufffd\ufffdWURFDV\ufffdQD\ufffdIDOD\ufffd\ufffd
IDOD\ufffd LQLQWHOLJtYHO\ufffd\ufffd FRPSRUWDPHQWR\ufffd DJLWDGR\ufffd H\ufffd
FRPSRUWDPHQWR\ufffd QHUYRVR\ufffd\ufffd 9HUL¿FRX\ufffdVH\ufffd DOWH\ufffd
UDomR\ufffdQD\ufffdIDOD\ufffdHP\ufffd\ufffd\ufffd\ufffd\ufffdGR\ufffdJUXSR\ufffdDYDOLDGR\ufffdH\ufffd
DOWHUDomR\ufffd DXGLWLYD\ufffd HP\ufffd \ufffd\ufffd\ufffd\ufffd\ufffd\ufffd 3DUD\ufffd DTXHOHV\ufffd
TXH\ufffdWLYHUDP\ufffdGLDJQyVWLFR\ufffdH\ufffdWUDWDPHQWR\ufffdPDLV\ufffd
WDUGLR\ufffdGR\ufffdKLSRWLUHRLGLVPR\ufffd\ufffdR\ufffdtQGLFH\ufffdGH\ufffdTXHL\ufffd
[DV\ufffdIRL\ufffdPDLRU\ufffdGR\ufffdTXH\ufffdSDUD\ufffdDTXHOHV\ufffdFRP\ufffdGLDJ\ufffd
QyVWLFR\ufffdH\ufffd WUDWDPHQWR\ufffd \ufffdPDLV\ufffdSUHFRFH\ufffd \ufffd)(5\ufffd
5(,5$\ufffdHW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd \ufffd$\ufffd LQFLGrQFLD\ufffdGR\ufffd+&\ufffdp\ufffd
YDULiYHO\ufffd\ufffdVHQGR\ufffdTXH\ufffdQR\ufffd%UDVLO\ufffd\ufffdHOD\ufffdp\ufffdGH\ufffdDSUR\ufffd
[LPDGDPHQWH\ufffd\ufffd\ufffdFDVR\ufffdSDUD\ufffdFDGD\ufffd\ufffd\ufffd\ufffd\ufffd\ufffdQDVFL\ufffd
GRV\ufffdYLYRV\ufffd\ufffd'(\ufffd&$59$/+2\ufffdHW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd
2\ufffd KLSRWLUHRLGLVPR\ufffd SULPiULR\ufffd \ufffd+3\ufffd\ufffd
SRGH\ufffdVHU\ufffdSHUPDQHQWH\ufffdRX\ufffd WUDQVLWyULR\ufffd\ufffd&HUFD\ufffd
GH\ufffd\ufffd\ufffd\ufffd\ufffdGR\ufffd+3\ufffdSHUPDQHQWH\ufffdp\ufffdGHFRUUHQWH\ufffdGH\ufffd
defeitos na formação glandular durante a 
HPEULRJrQHVH\ufffdH\ufffdp\ufffdGHQRPLQDGR\ufffdGLVJHQHVLD\ufffd
WLUHRLGLDQD\ufffd \ufffd./(77\ufffd\ufffd \ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd 3RU\ufffd RXWUR\ufffd ODGR\ufffd\ufffd
GHIHLWRV\ufffd JHQpWLFRV\ufffd QR\ufffd GHVHQYROYLPHQWR\ufffd H\ufffd
IXQomR\ufffd GD\ufffd KLSy¿VH\ufffd SRGHP\ufffd UHVXOWDU\ufffd HP\ufffd Yi\ufffd
ULDV\ufffdIRUPDV\ufffdGH\ufffdGH¿FLrQFLD\ufffdFDUDFWHUtVWLFDV\ufffdGR\ufffd
KLSRWLUHRLGLVPR\ufffd FHQWUDO\ufffd \ufffd3(5521(\ufffd HW\ufffd DO\ufffd\ufffd\ufffd
\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd2\ufffdKLSRWLUHRLGLVPR\ufffdFHQWUDO\ufffdRFRUUH\ufffdSRU\ufffd
GH¿FLrQFLD\ufffd GH\ufffd KRUP{QLRV\ufffd WLUHRLGLDQRV\ufffd SRU\ufffd
IDOWD\ufffdGH\ufffdHVWtPXOR\ufffdGR\ufffd76+\ufffdKLSR¿ViULR\ufffdRX\ufffdGR\ufffd
75+\ufffd\ufffdKRUP{QLR\ufffdOLEHUDGRU\ufffdGD\ufffdWLUHRWUR¿QD\ufffd\ufffdKL\ufffd
SRWDOkPLFR\ufffd\ufffd\ufffd
(QTXDQWR\ufffd LVVR\ufffd\ufffd R\ufffd KLSRWLUHRLGLV\ufffd
PR\ufffd VXEFOtQLFR\ufffd \ufffd+6\ufffd\ufffd RX\ufffd GRHQoD\ufffd WLUHRGLDQD 
PtQLPD\ufffd p\ufffd GH¿QLGR\ufffd SHOD\ufffd HOHYDomR\ufffd GR\ufffd QtYHO\ufffd
VpULFR\ufffdGR\ufffd76+\ufffd\ufffdDFLPD\ufffdGR\ufffdOLPLWH\ufffdVXSHULRU\ufffdGD\ufffd
QRUPDOLGDGH\ufffd\ufffdDVVRFLDGD\ufffdD\ufffdQtYHLV\ufffdQRUPDLV\ufffdGH\ufffd
WLUR[LQD\ufffdOLYUH\ufffd\ufffd7\ufffd/\ufffd\ufffd\ufffd3,0(17(/\ufffd	\ufffd+$16(1\ufffd\ufffd
\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd7(,;(,5$\ufffdHW\ufffdDO\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd\ufffd2XWUR\ufffdWUDED\ufffd
OKR\ufffd UHODWD\ufffd TXH\ufffdR\ufffd KLSRWLUHRLGLVPR\ufffd VXEFOtQLFR\ufffd
\ufffd6+7\ufffd\ufffd p\ufffd XPD\ufffd GLVIXQomR\ufffd FDUDFWHUL]DGD\ufffd SRU\ufffd
YDORU\ufffd VpULFR\ufffd DXPHQWDGR\ufffd GR\ufffd76+\ufffd FRP\ufffd FRQ\ufffd
FHQWUDo}HV\ufffdQRUPDLV\ufffdGH\ufffd7\ufffd\ufffdH\ufffd7\ufffd\ufffd\ufffdQD\ufffdDXVrQ\ufffd
FLD\ufffd GH\ufffd VLQWRPDV\ufffd FOtQLFRV\ufffd PDQLIHVWRV\ufffd\ufffd (VWD\ufffd
HQWLGDGH\ufffd Mi\ufffd IRL\ufffd GHQRPLQDGD\ufffd GH\ufffd KLSRWLUHRL\ufffd
GLVPR\ufffdSUpFOtQLFR\ufffd\ufffdGLPLQXLomR\ufffdGD\ufffdUHVHUYD\ufffdGD\ufffd
WLUHRLGH\ufffdRX\ufffdPL[HGHPD\ufffdSUp\ufffdFOtQLFR\ufffd\ufffd520$/\ufffd