<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/35da187a-909b-4d25-92ce-1983166615f3/bg1.png"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls0 ws0">Enzimas<span class="ff2 ls1 ws1">\ue003<span class="_0 blank"></span>\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003<span class="ff1 ls2 ws2">Cacá</span><span class="ls3">\ue003<span class="ff1 ls6c ws3">Filh<span class="_1 blank"></span>o<span class="ff2 ls3">\ue003</span><span class="ls6d ws4">\u2013<span class="ff2 ls3">\ue003</span><span class="ls4 ws5">MED</span><span class="ff2 ws6">\ue003</span><span class="ls6e ws7">21<span class="ff2 ls3">\ue003\ue003</span></span></span></span></span></span></div><div class="t m0 x1 h3 y2 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x2 h4 y3 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls6f ws8">Enzimas</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls70 wsa">são<span class="ff3 ls7">\ue003</span><span class="ls71 wsb">proteínas</span></span><span class="ff3 ls6d ws9">\ue003<span class="_1 blank"></span><span class="ff6 ls8 wsc">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls9 wsd">catalisam<span class="ff3 ls7">\ue003</span><span class="ls72 wse">as<span class="ff3 ls7">\ue003</span><span class="ls73 wsf">reaç õ e<span class="_2 blank"> </span>s<span class="ff3 ls6d ws9">\ue003</span><span class="ls21 ws10">biológicas.<span class="ff3 ls74">\ue003\ue003</span></span></span></span></span></span></span></div><div class="t m0 x2 h4 y4 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 lsa ws11">Sem</span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ff6 ls12 ws13">catálise,</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls72 wse">as<span class="ff3 ls7">\ue003</span><span class="ls75 ws14">reações</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls16 ws15">químic<span class="_1 blank"></span>as<span class="ff3 ls6d ws9">\ue003</span><span class="lsb ws16">necessárias<span class="ff3 ls7">\ue003</span><span class="ls76 ws17">para<span class="ff3 ls7">\ue003</span><span class="lsc ws18">sustentar<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ws9">\ue003<span class="_1 blank"></span><span class="ff6 ls77 ws19">vida<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">não<span class="ff3 ls6d ws9">\ue003</span><span class="ls78 ws1a">ocorreriam<span class="_1 blank"></span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ls79 ws1b">em</span>\ue003<span class="ff6 ls22 ws1c">tempo</span><span class="ls7">\ue003<span class="ff6 ls7a ws1d">útil.</span></span>\ue003</span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x2 h4 y5 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls6f ws8">As<span class="ff3 ls7">\ue003</span><span class="lsd ws1e">enzimas</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls75 ws14">são<span class="ff3 ls7">\ue003</span><span class="ls72 wse">as</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls9 wsd">mais<span class="ff3 ls7">\ue003</span><span class="lse ws1f">notáveis</span></span><span class="ff3 ls6d ws9">\ue003<span class="ff6 lsf">e</span>\ue003</span><span class="ff6 ls7b ws20">altamente</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls77 ws21">especializadas<span class="ff3 ls7">\ue003</span><span class="ls14 ws22">proteínas.<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x2 h4 y6 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls6f ws8">As<span class="ff3 ls7">\ue003</span><span class="ls7c ws23">inte raçõ e s</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 lsd ws1e">fr<span class="_2 blank"> </span>acas</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls8 wsc">que</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls7d ws24">se</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls9 wsd">estabelecem</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls10 ws25">entre</span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ff6 ls79 ws1b">en<span class="_1 blank"></span>zima<span class="_1 blank"></span><span class="ff3 ls6d ws9">\ue003<span class="ff6 lsf">e</span>\ue003<span class="ff6 ls11">o</span>\ue003<span class="ff6 ls6f ws26">substrato</span>\ue003<span class="ff6 ls75 ws14">são</span>\ue003<span class="ff6 ls7e ws27">usadas </span>\ue003<span class="ff6 ls7f ws28">para</span><span class="ls7">\ue003<span class="ff6 ls12 ws13">distorcer</span>\ue003</span><span class="ff6 ws12">a</span><span class="ls7">\ue003<span class="ff6 ls7c ws29">molécul a</span></span>\ue003</span></span></div><div class="t m0 x0 h4 y7 ff6 fs1 fc1 sc0 ls80 ws2a">do<span class="ff3 ls6d ws9">\ue003</span><span class="ls13 ws2b">substrato<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">e<span class="ff3 ls6d ws9">\ue003</span><span class="lsb ws2c">catalisar<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ls7">\ue003</span><span class="ls81 ws2d">reação</span><span class="ff3">\ue003</span></span></span></span></span></div><div class="t m0 x2 h4 y8 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls6d ws12">A<span class="ff3 ws9">\ue003</span><span class="ls82 ws2e">maiori<span class="_1 blank"></span>a<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">das<span class="ff3 ls6d ws9">\ue003</span><span class="lsd ws1e">enzimas<span class="ff3 ls6d ws9">\ue003</span><span class="ls70 wsa">sã<span class="_1 blank"></span>o<span class="ff3 ls7">\ue003</span><span class="ls71 wsb">proteínas.<span class="ff3 ls7">\ue003</span><span class="ls22 ws1c">E<span class="_1 blank"></span>ntão,<span class="ff3 ls6d ws9">\ue003</span><span class="lsc ws18">suas<span class="ff3 ls6d ws9">\ue003</span><span class="ls9 wsd">estruturas<span class="ff3 ls6d ws9">\ue003</span><span class="ls7f ws28">proteic<span class="_1 blank"></span>as<span class="ff3 ls7">\ue003</span><span class="ls16 ws15">pri<span class="_1 blank"></span>marias,<span class="ff3 ls6d ws9">\ue003</span><span class="ls13 ws2b">secu<span class="_1 blank"></span>ndarias,<span class="ff3 ls7">\ue003</span><span class="ls83 ws2f">terciarias<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">e<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x0 h4 y9 ff6 fs1 fc1 sc0 ls84 ws30">quaternárias <span class="ff3 ls7">\ue003</span><span class="ls7d ws24">são<span class="ff3 ls6d ws9">\ue003</span><span class="ls85 ws31">essenc<span class="_1 blank"></span>iais<span class="_1 blank"></span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ls7e ws32">para</span>\ue003<span class="ff6 ls14 ws22">sua</span><span class="ls7">\ue003<span class="ff6 ls84 ws33">atividade</span>\ue003<span class="ff6 ls86 ws34">cat<span class="_2 blank"> </span>alíti c a.<span class="_2 blank"> </span></span></span>\ue003</span></span></span></div><div class="t m0 x2 h4 ya ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls81 ws35">Algumas</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls4c ws36">enzimas<span class="ff3 ls7">\ue003</span><span class="ls8 wsc">não<span class="ff3 ls7">\ue003</span><span class="ls75 ws37">requerem</span></span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls80 ws38">nenhum</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls15 ws39">outro<span class="ff3 ls7">\ue003</span><span class="ls87 ws3a">grupo</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls16 ws15">qu<span class="_1 blank"></span>ímico<span class="ff3 ls7">\ue003</span><span class="ls17 ws3b">além<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws2a">de<span class="ff3 ls6d ws9">\ue003</span><span class="ls70 wsa">se<span class="_1 blank"></span>us<span class="ff3 ls6d ws9">\ue003</span><span class="lsa ws11">aminoác<span class="_1 blank"></span>idos.<span class="ff3 ls7">\ue003</span><span class="ls81 ws35">Algumas<span class="ff3 ls7">\ue003</span><span class="ls74 ws3c">outras<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m0 x0 h4 yb ff6 fs1 fc1 sc0 ls88 ws3d">requerem<span class="ff3 ls7">\ue003</span><span class="ls18 ws3e">componentes<span class="ff3 ls6d ws9">\ue003</span><span class="ls4d ws3f">químicos<span class="ff3 ls7">\ue003</span><span class="ls70 wsa">a<span class="_1 blank"></span>dicio<span class="_1 blank"></span>nai<span class="_1 blank"></span>s<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls75 ws40">são<span class="ff3 ls6d ws9">\ue003</span><span class="ls89 ws41">chamado<span class="ff3 ls6d ws9">\ue003</span></span></span>de<span class="ff3 ls7">\ue003<span class="ff7 ls7b ws42">co<span class="ff8 ls19">\u2010</span><span class="ls8a ws43">fator<span class="ff8 ls6d ws9">\ue003</span></span></span></span><span class="ws44">(que<span class="ff3 ls6d ws9">\ue003</span></span>pode<span class="ff3 ls6d ws9">\ue003</span></span>ser<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws2a">um<span class="ff3 ls7">\ue003<span class="ff7 ls1a ws45">íon<span class="ff8 ls6d ws9">\ue003</span><span class="ls88 ws46">inorgânico</span></span><span class="ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x0 h4 yc ff6 fs1 fc1 sc0 ls22 ws1c">ou<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws30">uma<span class="ff3 ls7">\ue003<span class="ff7 ls8b ws40">coenzima<span class="ff8 ls6d ws9">\ue003</span></span></span><span class="ls17 ws3b">[molécula<span class="ff3 ls6d ws9">\ue003</span><span class="ls8c ws47">orgâ<span class="_1 blank"></span>nica<span class="_1 blank"></span><span class="ff3 ls7">\ue003<span class="ff6 ls10 ws25">complexa</span><span class="ls6d ws9">\ue003<span class="ff6 ls22 ws1c">ou</span>\ue003<span class="ff6 ls8 wsc">uma</span>\ue003<span class="ff6 ls20 ws48">molécula</span></span>\ue003<span class="ff6 ls6d ws49">m<span class="_1 blank"></span>etalorgânica]).<span class="ff3">\ue003</span></span></span></span></span></span></div><div class="t m0 x1 h5 yd ff2 fs2 fc0 sc0 ls6d">\ue003</div><div class="t m0 x1 h6 ye ff1 fs2 fc0 sc0 ls1b ws4a">As<span class="ff2">\ue003</span><span class="ls8d ws4b">enzim<span class="_2 blank"> </span>as<span class="ff2 ls6d ws4c">\ue003</span><span class="ls8e ws4d">são</span></span><span class="ff2">\ue003</span>classifica<span class="_1 blank"></span>das<span class="ff2">\ue003</span><span class="ls8f ws4e">pelas<span class="ff2 ls6d ws4c">\ue003</span><span class="ls90 ws4f">rea<span class="_1 blank"></span>ções<span class="ff2 ls6d ws4c">\ue003</span><span class="ls8f ws4e">que<span class="ff2 ls6d ws4c">\ue003<span class="_1 blank"></span><span class="ff1 ls91 ws50">catalisam<span class="ff2 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x2 h4 yf ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 lsf ws51">Se</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls1c ws52">tem</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls92 ws53">\u201case\u201d<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">no</span></span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 lsd ws1e">nome,</span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ls1d">é</span>\ue003</span><span class="ff6 ls4c ws36">enzima.</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls93 ws54">Então</span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span><span class="ls7">\ue003</span></span><span class="ff6 ls80 ws55">parte</span><span class="ff3 ls6d ws9">\ue003</span><span class="ff6 ls22 ws1c">anterior</span><span class="ff3 ls6d ws9">\ue003<span class="_1 blank"></span><span class="ff6 ls80 ws2a">do<span class="ff3 ls7">\ue003</span><span class="ls94 ws56">\u201case\u201d<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">é<span class="ff3 ls7">\ue003</span><span class="ls1e ws57">relativa<span class="ff3 ls6d ws9">\ue003</span><span class="ls72 wse">ao<span class="ff3 ls6d ws9">\ue003</span><span class="ls82 ws2e">substr<span class="_1 blank"></span>ato<span class="ff3 ls6d ws9">\ue003</span><span class="ls95 ws58">(ex:<span class="ff3 ls7">\ue003</span><span class="ls96 ws59">Urease<span class="ff3 ls74 ws5a">\ue003\u2010</span><span class="ls1d">><span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x0 h4 y10 ff6 fs1 fc1 sc0 ls97 ws5b">Enzima<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls1f ws5c">catalisa<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ws9">\ue003</span><span class="ls20 ws5d">hidrólise</span><span class="ff3 ws9">\ue003</span><span class="ls80 ws2a">de</span><span class="ff3 ws9">\ue003</span><span class="ls95 ws5e">Uréia).</span><span class="ff3">\ue003</span></span></span></span></div><div class="t m0 x2 h4 y11 ff4 fs1 fc1 sc0 ls5">\uf0b7<span class="ff5 ls6 wsc1"> </span><span class="ff6 ls6d ws12">A<span class="ff3 ws9">\ue003</span><span class="ls1f ws5c">classificação</span><span class="ff3 ws9">\ue003</span><span class="ls80 ws2a">da</span><span class="ff3 ws9">\ue003</span><span class="ls4c ws36">enzima</span><span class="ff3 ws9">\ue003</span><span class="ls70 wsa">se</span><span class="ff3 ws9">\ue003</span><span class="ls10 ws25">baseia</span><span class="ff3 ws9">\ue003</span><span class="lse ws1f">em</span><span class="ff3 ws9">\ue003</span><span class="ls21 ws5f">6(seis)</span><span class="ff3 ws9">\ue003</span><span class="ls80 ws38">grandes</span><span class="ff3 ws9">\ue003</span><span class="lsc ws18">classes,</span><span class="ff3 ws9">\ue003</span><span class="ls98 ws60">cada</span><span class="ff3 ws9">\ue003</span><span class="ls22 ws1c">uma</span><span class="ff3 ws9">\ue003</span><span class="ls23 ws61">com</span><span class="ff3 ws9">\ue003</span><span class="ls99 ws62">subclasses,</span><span class="ff3 ws9">\ue003</span><span class="lsb ws2c">conforme</span><span class="ff3 ws9">\ue003</span><span class="ls11">o</span><span class="ff3 ws9">\ue003</span><span class="ls71 wsb">tipo<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">de</span></span><span class="ff3">\ue003</span></span></div><div class="t m0 x0 h4 y12 ff6 fs1 fc1 sc0 ls81 ws2d">reação<span class="ff3 ls7">\ue003</span><span class="lsb ws2c">catalisada.<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x0 h3 y13 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x3 h7 y14 ff7 fs3 fc1 sc0 ls9a ws63">Classificação<span class="ff8 ls6d ws64">\ue003</span><span class="ls9b ws65">das<span class="ff8 ls6d ws64">\ue003</span></span><span class="ws66">Enzim as<span class="ff8 ls6d">\ue003</span></span></div><div class="t m0 x4 h8 y15 ff7 fs1 fc1 sc0 ls13 ws2b">Número<span class="ff8 ls24">\ue003</span><span class="lsc ws18">Classe<span class="ff8 ls25">\ue003</span><span class="ls1f ws5c">Tipo<span class="ff8 ls6d ws9">\ue003</span><span class="ls23 ws61">de<span class="ff8 ls6d ws9">\ue003</span><span class="ls88 ws67">Reação<span class="ff8 ls6d ws9">\ue003</span><span class="ls26 ws68">Catalisada<span class="ff8 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x5 h9 y16 ff6 fs1 fc1 sc0 ls1a">1<span class="ff3 ls27">\ue003</span><span class="ls8a ws43">Oxidorredutases<span class="ff3 ls28">\ue003</span></span><span class="fs4 ls9c ws69 v1">Transferência<span class="ff3 ls29">\ue003<span class="ff6 ls9d ws6a">de</span><span class="ls2a">\ue003<span class="ff6 ls9e ws6b">Elétrons<span class="_1 blank"></span><span class="ff3 ls2a">\ue003<span class="ff6 ls2b ws6c">(íons</span><span class="ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x6 ha y17 ff6 fs4 fc1 sc0 ls9d ws6a">hidret<span class="_1 blank"></span>os<span class="ff3 ls6d ws6d">\ue003</span><span class="ls9f ws6e">ou<span class="ff3 ls2c">\ue003</span><span class="lsa0 ws6f">átom<span class="_1 blank"></span>os<span class="ff3 ls2c">\ue003</span><span class="lsa1 ws70">de<span class="ff3 ls2c">\ue003</span><span class="lsa2 ws71">H).<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x5 h9 y18 ff6 fs1 fc1 sc0 ls1a">2<span class="ff3 ls2d">\ue003</span><span class="ls17 ws3b">Transferases<span class="ff3 ls2e">\ue003</span></span><span class="fs4 lsa3 ws72 v1">Reação<span class="ff3 ls2f">\ue003<span class="ff6 ls9d ws6a">de</span>\ue003<span class="ff6 lsa4 ws73">transferên<span class="_2 blank"> </span>cia</span><span class="ls30">\ue003<span class="ff6 lsa1 ws70">de</span><span class="ls6d">\ue003</span></span></span></span></div><div class="t m0 x6 ha y19 ff6 fs4 fc1 sc0 ls31 ws74">grupos.<span class="ff3 ls6d">\ue003</span></div><div class="t m0 x5 h4 y1a ff6 fs1 fc1 sc0 ls1a">3<span class="ff3 ls32">\ue003</span><span class="ls33 ws75">Hidrolases<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x6 ha y1b ff6 fs4 fc1 sc0 lsa5 ws76">Reações<span class="ff3 ls34">\ue003</span><span class="ls9d ws6a">de<span class="ff3 ls34">\ue003</span><span class="lsa6 ws77">Hidrólise<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x6 ha y1c ff6 fs4 fc1 sc0 lsa7 ws78">(transferência<span class="ff3 ls35">\ue003</span><span class="ls9d ws6a">de<span class="ff3 ls36">\ue003</span><span class="ls2c ws79">grupos<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x6 ha y1d ff6 fs4 fc1 sc0 ls9d ws6a">funci<span class="_1 blank"></span>onais<span class="ff3 ls2c">\ue003</span><span class="lsa8 ws7a">para<span class="ff3 ls2c">\ue003<span class="ff6">a</span>\ue003</span><span class="lsa9 ws7b">água)<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x5 h4 y1e ff6 fs1 fc1 sc0 ls1a">4<span class="ff3 ls37">\ue003</span><span class="ls12 ws13">Liases<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x6 ha y1f ff6 fs4 fc1 sc0 lsaa ws7c">Adição<span class="ff3 ls38">\ue003</span><span class="ls9d ws6a">dos<span class="ff3 ls39">\ue003</span><span class="lsab ws7d">grupos <span class="ff3 ls39">\ue003</span><span class="lsac ws7e">às <span class="ff3 ls39">\ue003</span><span class="lsad ws7f">duplas<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x6 ha y20 ff6 fs4 fc1 sc0 lsae ws80">ligações<span class="ff3 ls3a">\ue003</span><span class="ls9f ws6e">ou<span class="ff3 ls3b">\ue003</span><span class="lsaf ws81">formação<span class="ff3 ls3c">\ue003</span><span class="ls9d ws6a">de<span class="ff3 ls3a">\ue003</span><span class="lsb0 ws82">duplas<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x6 ha y21 ff6 fs4 fc1 sc0 lsae ws80">ligações<span class="ff3 ls3d">\ue003</span><span class="ls3e ws83">por<span class="ff3 ls3d">\ue003</span><span class="ls31 ws84">meio<span class="ff3 ls3d">\ue003</span><span class="lsa1 ws70">da<span class="ff3 ls3d">\ue003</span><span class="lsb1 ws85">remoç<span class="_1 blank"></span>ão<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x6 ha y22 ff6 fs4 fc1 sc0 lsa1 ws70">de<span class="ff3 ls2c">\ue003</span><span class="ls31 ws74">grupos.<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x5 h4 y23 ff6 fs1 fc1 sc0 ls1a">5<span class="ff3 ls3f">\ue003</span><span class="ls17 ws3b">Isomerases<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x6 ha y24 ff6 fs4 fc1 sc0 ls9c ws69">Transferência<span class="ff3 ls40">\ue003</span><span class="ls9d ws6a">de<span class="ff3 ls41">\ue003</span><span class="lsb2 ws86">grupos<span class="ff3 ls41">\ue003</span></span>dentr<span class="_1 blank"></span>o<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x6 ha y25 ff6 fs4 fc1 sc0 lsa1 ws70">da<span class="ff3 ls6d ws6d">\ue003<span class="_1 blank"></span><span class="ff6 lsb3 ws87">mesma<span class="ff3 ls6d ws6d">\ue003<span class="_1 blank"></span><span class="ff6 ls31 ws74">molécula<span class="ff3 ls6d ws6d">\ue003<span class="_1 blank"></span><span class="ff6 lsa8 ws7a">para<span class="ff3 ls6d ws6d">\ue003<span class="_1 blank"></span><span class="ff6 lsb4 ws88">formar<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x6 ha y26 ff6 fs4 fc1 sc0 lsa8 ws7a">isômeros.<span class="ff3 ls6d">\ue003</span></div><div class="t m0 x5 h4 y27 ff6 fs1 fc1 sc0 ls1a">6<span class="ff3 ls42">\ue003</span><span class="lsb5 ws89">Ligases<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x6 ha y28 ff6 fs4 fc1 sc0 lsb6 ws8a">Form<span class="_2 blank"> </span>ação<span class="_2 blank"> </span><span class="ff3 ls43">\ue003</span><span class="lsa1 ws70">de<span class="ff3 ls44">\ue003</span><span class="ls9c ws69">ligações<span class="ff3 ls43">\ue003</span><span class="ls9d ws6a">do<span class="ff3 ls44">\ue003</span><span class="lsb7 ws8b">tipo<span class="ff3 ls44">\ue003</span><span class="ls6d ws8c">C<span class="ff3">\u2010</span></span></span></span></span></span></div><div class="t m0 x6 ha y29 ff6 fs4 fc1 sc0 lsb8 ws8d">C,<span class="ff3 ls45">\ue003</span><span class="ls6d ws8c">C<span class="ff3 ws6d">\u2010</span><span class="lsb9 ws8e">S,<span class="ff3 ls46">\ue003</span></span>C<span class="ff3 ws6d">\u2010</span><span class="lsba ws8f">O,<span class="ff3 ls46">\ue003</span></span>C<span class="ff3 ws6d">\u2010</span><span class="ls47">N<span class="ff3 ls48">\ue003</span><span class="lsa1 ws70">por<span class="ff3 ls45">\ue003</span><span class="lsbb ws90">mei<span class="_1 blank"></span>o<span class="ff3 ls45">\ue003</span><span class="lsa1 ws70">de<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x6 ha y2a ff6 fs4 fc1 sc0 lsbc ws91">reações<span class="ff3 ls35">\ue003</span><span class="ls9d ws6a">de<span class="ff3 ls36">\ue003</span><span class="lsbd ws92">condens<span class="_2 blank"> </span>ação<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x6 ha y2b ff6 fs4 fc1 sc0 lsbe ws93">acopladas <span class="ff3 ls2c">\ue003<span class="ff6">a</span><span class="ls6d ws6d">\ue003</span></span><span class="ls9d ws6a">quebra<span class="ff3 ls6d ws6d">\ue003</span>do<span class="ff3 ls2c">\ue003</span><span class="lsbf ws94">ATP.<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x1 h3 y2c ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 h5 y2d ff2 fs2 fc0 sc0 ls6d">\ue003</div><div class="t m0 x1 h3 y2e ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 h6 y2f ff1 fs2 fc0 sc0 lsc0 ws95">Como<span class="ff2 ls1b">\ue003</span><span class="lsc1 ws96">as<span class="ff2 ls1b">\ue003</span><span class="ls49 ws97">enzimas<span class="ff2 ls1b">\ue003</span><span class="lsc2 ws98">funcionam<span class="ff2 ls6d">\ue003</span></span></span></span></div><div class="t m0 x7 h4 y30 ff4 fs1 fc1 sc0 ls6d ws9">\uf0b7<span class="ff5 ls4a wsc1"> </span><span class="ff6 ws12">A</span><span class="ff3">\ue003<span class="ff6 ls15 ws39">enzima</span>\ue003<span class="ff6 lsc3 ws99">fornece</span>\ue003<span class="ff6 ls80 ws2a">um</span><span class="ls7">\ue003<span class="ff6 lsc4 wsf">amb<span class="_2 blank"> </span>ient e<span class="_2 blank"> </span></span></span>\ue003<span class="ff6 ls4b ws9a">específico</span>\ue003<span class="ff6 ls80 ws2a">onde</span>\ue003<span class="ff6 ls80 ws30">uma</span><span class="ls7">\ue003<span class="ff6 ls7e ws32">dada</span>\ue003<span class="ff6 ls81 ws2d">reação</span>\ue003<span class="ff6 lsf">é</span></span>\ue003<span class="ff6 ls79 ws1b">energi<span class="_1 blank"></span>camen<span class="_1 blank"></span>te<span class="ff3 ls6d ws9">\ue003</span><span class="ls9 wsd">mais<span class="ff3 ls6d ws9">\ue003</span><span class="ls4b ws9a">favorável.<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x7 h4 y31 ff4 fs1 fc1 sc0 ls6d ws9">\uf0b7<span class="ff5 ls4a wsc1"> </span><span class="ff6 ws12">A</span><span class="ff3">\ue003<span class="ff6 ls81 ws2d">reação</span>\ue003<span class="ff6 lsc5 ws20">ocorre</span>\ue003<span class="ff6 ls8 wsc">no</span><span class="ls7">\ue003<span class="ff6 lsc6 ws9b">inte rio r </span>\ue003<span class="ff6 ls80 ws2a">dos<span class="_2 blank"> </span></span></span>\ue003<span class="ff6 ls20 ws48">limites</span>\ue003<span class="ff6 ls8 wsc">de</span>\ue003<span class="ff6 ls80 ws30">uma</span><span class="ls7">\ue003<span class="ff6 ls8a ws43">cavidade</span></span>\ue003<span class="ff6 ls8 wsc">na</span>\ue003<span class="ff6 ls15 ws39">enz<span class="_1 blank"></span>ima<span class="ff3 ls7">\ue003</span><span class="ls98 ws60">chamada<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">de<span class="ff3 ls6d ws9">\ue003<span class="ff7 ls1f ws5c">sítio</span><span class="ff8">\ue003<span class="ff7 ls4c ws36">ativo.</span></span>\ue003</span></span></span></span></span></div><div class="t m0 x7 h4 y32 ff4 fs1 fc1 sc0 ls6d ws9">\uf0b7<span class="ff5 ls4a wsc1"> </span><span class="ff6 ws12">A</span><span class="ff3">\ue003<span class="ff6 ls20 ws48">molécula</span>\ue003<span class="ff6 ls8 wsc">que</span>\ue003<span class="_1 blank"></span><span class="ff6 ls70 wsa">se<span class="ff3 ls6d ws9">\ue003</span><span class="ls10 ws25">liga<span class="ff3 ls7">\ue003</span><span class="ls72 wse">ao<span class="ff3 ls7">\ue003</span><span class="ls4d ws3f">sítio<span class="ff3 ls6d ws9">\ue003</span><span class="lsd ws1e">ativo<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">e<span class="ff3 ls6d ws9">\ue003</span><span class="ls71 wsb">sofra<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span><span class="ls7">\ue003</span></span><span class="lsc7 ws9c">ação<span class="ff3 ls7">\ue003</span><span class="ls8 wsc">da<span class="_1 blank"></span><span class="ff3 ls6d ws9">\ue003<span class="ff6 ls79 ws1b">enzim<span class="_1 blank"></span>a<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">é<span class="ff3 ls6d ws9">\ue003</span><span class="ls92 ws53">chamada<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws9d">de<span class="ff3 ls6d ws9">\ue003<span class="ff7 ls4c ws36">substrato</span></span><span class="ls20 v0">.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h3 y33 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 hb y34 ff1 fs3 fc2 sc0 ls4e ws9e">IMPORTANTE:<span class="_1 blank"></span><span class="ff2 ls6d ws64">\ue003<span class="ff1 lsc8 ws9f">AS</span>\ue003<span class="ff1 lsc9 wsa0">ENZIMAS</span>\ue003<span class="ff1 lsc9 wsa0">AFETAM</span>\ue003<span class="ff1 ls4f">A</span>\ue003<span class="ff1 lsca wsa1">VELOCIDADE</span>\ue003<span class="ff1 ls5a wsa2">MAS</span>\ue003<span class="ff1 ls50 wsa3">NÃO</span>\ue003<span class="ff1 ls51">O</span>\ue003<span class="ff1 lscb wsa4">EQUILÍBRIO</span>\ue003<span class="ff1 lsca wsa1">DAS</span>\ue003<span class="ff1 ls52 wsa5">REAÇÕES</span>\ue003</span></div><div class="t m0 x1 h4 y35 ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls99 ws62">Portanto,</span><span class="ls7">\ue003<span class="ff6 ls6d ws12">a</span>\ue003<span class="ff6 ls72 wse">reação</span>\ue003<span class="ff6 ls80 ws2a">pode</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls70 wsa">ser</span><span class="ls6d ws9">\ue003<span class="_1 blank"></span><span class="ff6 ls1f ws5c">escrita<span class="ff3 ls6d ws9">\ue003</span>assim:<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m0 x8 hc y36 ff9 fs1 fc1 sc0 ls54">\ue727<span class="lscc wsa6">\ued45\ue735<span class="_3 blank"></span>\ue003 <span class="lscd wsa7">\u2194\ue727<span class="_4 blank"></span>\ue735<span class="_4 blank"></span>\ue003\u2194\ue727<span class="_4 blank"></span>\ue732<span class="_5 blank"></span>\ue003<span class="lsce wsa8">\u2194\ue727<span class="lscc wsa9">\ued45\ue732<span class="_5 blank"></span><span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x1 h3 y37 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x9 hd y38 ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº1]: <span class="_1 blank"></span><span class="ff6 lsd0 wsaa">Elas<span class="ff3 ls6d wsab">\ue003</span><span class="ls52 wsac">tem<span class="ff3 ls6d wsab">\ue003</span><span class="ls5a wsad">um<span class="ff3 ls55">\ue003</span><span class="lsd1 wsae">alto<span class="ff3 ls55">\ue003</span><span class="lsd2 wsaf">gra u <span class="ff3 ls55">\ue003</span></span></span>de<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m0 x9 hd y39 ff6 fs5 fc1 sc0 lsd3 wsb0">especificidade<span class="ff3 ls6d wsab">\ue003</span><span class="lsd4 wsa1">por<span class="ff3 ls6d wsab">\ue003</span><span class="ls56 wsb1">seus<span class="ff3 ls6d wsab">\ue003</span><span class="ls57 wsb2">substratos,<span class="ff3 ls6d wsab">\ue003</span><span class="lsd5 wsb3">aceleram<span class="ff3 ls6d wsab">\ue003</span><span class="lsd6 wsb4">reações<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x9 hd y3a ff6 fs5 fc1 sc0 ls56 wsb1">químicas<span class="ff3 ls6d wsab">\ue003</span><span class="ls5a wsad">de<span class="ff3 ls55">\ue003</span><span class="lsd7 wsb5">maneira<span class="ff3 ls55">\ue003</span><span class="lsd8 wsb6">formidável<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">e</span>\ue003</span><span class="ls58 wsb8">funcionam<span class="ff3 ls55">\ue003</span><span class="ls68 wsb9">em<span class="ff3 ls6d wsab">\ue003</span><span class="ls59 wsba">soluções<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m0 x9 hd y3b ff6 fs5 fc1 sc0 ls5a wsad">aquosas<span class="ff3 ls6d wsab">\ue003</span><span class="ls59 wsba">sob<span class="ff3 ls6d wsab">\ue003</span><span class="ls57 wsb2">condições<span class="ff3 ls6d wsab">\ue003</span><span class="lsd9 wsbb">muito<span class="ff3 ls6d wsab">\ue003</span><span class="ls56 wsb1">suaves<span class="ff3 ls6d wsab">\ue003</span><span class="lsda wsbc">de<span class="ff3 ls6d wsab">\ue003</span><span class="ls5b wsbd">temperatura<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">e</span>\ue003</span><span class="lsdb wsbe">pH.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m0 x9 hd y3c ff6 fs5 fc1 sc0 ls68 wsb9">Pouquíssimos<span class="ff3 ls6d wsab">\ue003</span><span class="lsdc wsbf">cata li<span class="_2 blank"> </span>zador e s <span class="ff3 ls6d wsab">\ue003</span><span class="ls5b wsc0">não<span class="ff3 ls6d wsab">\u2010</span><span class="lsd7 wsc1">biol<span class="_2 blank"> </span>ógicos<span class="ff3 ls6d wsab">\ue003</span><span class="ls62 wsc2">apre<span class="_1 blank"></span>senta<span class="_1 blank"></span>m<span class="ff3 ls6d wsab">\ue003</span><span class="ls58 wsb8">tais<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x9 hd y3d ff6 fs5 fc1 sc0 lsdd wsc3">prop<span class="_1 blank"></span>riedad<span class="_1 blank"></span>es.<span class="ff3 ls6d">\ue003</span></div><div class="t m0 x9 hd y3e ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº2]: <span class="_1 blank"></span><span class="ff6 lsd4 wsa1">Existe<span class="ff3 ls55">\ue003</span><span class="ls5a wsad">um<span class="ff3 ls6d wsab">\ue003</span>pequeno<span class="ff3 ls6d wsab">\ue003</span><span class="lsd5 wsb3">grupo<span class="ff3 ls6d wsab">\ue003</span></span>de<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x9 hd y3f ff6 fs5 fc1 sc0 lsde wsc4">moléculas<span class="ff3 ls6d wsab">\ue003</span><span class="lsdf wsc5">de<span class="ff3 ls6d wsab">\ue003</span><span class="ls52 wsac">RNA<span class="ff3 ls6d wsab">\ue003</span><span class="ls5a wsad">que<span class="ff3 ls6d wsab">\ue003</span><span class="ls5c wsc6">também<span class="ff3 ls6d wsab">\ue003</span><span class="ls5d wsc7">apresentam<span class="ff3 ls6d wsab">\ue003</span><span class="ls5b wsc0">propriedades<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m0 x9 hd y40 ff6 fs5 fc1 sc0 lse0 wsc8">catalíticas.<span class="ff3 ls6d">\ue003</span></div><div class="t m0 x9 he y41 ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº3]: <span class="_1 blank"></span><span class="ff6 ls5d wsc7">Fe<span class="fs6 lse1 wsb3 v2">2+</span><span class="ls5e">,<span class="ff3 ls6d wsab">\ue003</span><span class="lsd6 wsb4">Mg<span class="fs6 lse1 wsb3 v2">2+</span><span class="ls5f wsc9">,Mn<span class="fs6 lse1 wsb3 v2">2+</span><span class="lse2 wsca">,Zn<span class="fs6 lse1 wsb3 v2">2+</span><span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x9 hd y42 ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº4]: <span class="_1 blank"></span><span class="ff3 ls60">\u2192<span class="ff6 ls6d wsb7">A<span class="ff3 wsab">\ue003</span><span class="lse3 wscb">coenzima,</span><span class="ff3 wsab">\ue003</span><span class="lse4 wscc">ou</span></span><span class="ls55">\ue003<span class="ff6 ls6d wsb7">o<span class="ff3 wsab">\ue003</span><span class="lse5 wscd">íon</span><span class="ff3 wsab">\ue003</span><span class="lse6 wsce">metál i co ,</span><span class="ff3">\ue003</span></span></span></span></div><div class="t m0 x9 hd y43 ff6 fs5 fc1 sc0 ls5a wsad">que<span class="ff3 ls6d wsab">\ue003</span><span class="ls61 wscf">está<span class="ff3 ls6d wsab">\ue003</span><span class="lsdb wsbe">ligado<span class="ff3 ls6d wsab">\ue003</span><span class="ls62">à<span class="ff3 ls6d wsab">\ue003</span><span class="ls5d wsc7">parte<span class="ff3 ls6d wsab">\ue003</span><span class="lsd6 wsb4">proteica<span class="ff3 ls6d wsab">\ue003</span></span></span></span></span></span>da<span class="ff3 ls6d wsab">\ue003</span><span class="lsde wsc4">enzima<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">é</span>\ue003</span><span class="ls6a wsd0">denominada<span class="ff3 ls6d wsab">\ue003</span></span></span>de<span class="ff3 ls6d">\ue003</span></div><div class="t m0 x9 hd y44 ff7 fs5 fc1 sc0 lsdb wsbe">grupo<span class="ff8 ls6d wsab">\ue003</span><span class="ls63 wsd1">prostético<span class="ff6 ls58">.<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x9 hd y45 ff3 fs5 fc1 sc0 ls6d wsab">\u2192<span class="ff6 lse7 wsd2">Uma</span>\ue003<span class="ff6 lsd5 wsb3">enzima</span><span class="ls55">\ue003<span class="ff6 lsdc wsbf">complet a </span></span>\ue003<span class="ff6 wsb7">e</span>\ue003<span class="ff6 ls64 wsd3">catali</span><span class="ls65">\ue19f<span class="ff6 lse8 wsd4">ca<span class="_2 blank"> </span>mente</span></span>\ue003<span class="ff6 wsb7">a</span><span class="ls66">\ue19f<span class="ff6 lsd4 wsa1">va,<span class="_2 blank"> </span></span></span>\ue003<span class="ff6 ls63 wsd5">juntamente</span>\ue003</div><div class="t m0 x9 hd y46 ff6 fs5 fc1 sc0 lsdc wsd6">com<span class="ff3 ls6d wsab">\ue003</span><span class="ls67 wsd7">sua<span class="ff3 ls6d wsab">\ue003</span><span class="lse9 wsd8">coenzima<span class="ff3 ls55">\ue003</span><span class="lsde wsc4">e/ou<span class="ff3 ls6d wsab">\ue003</span><span class="lsea wsd9">íons<span class="_2 blank"> </span><span class="ff3 ls6d wsab">\ue003</span><span class="lse7 wsd2">metá<span class="_1 blank"></span>licos<span class="ff3 ls6d wsab">\ue003</span>lig<span class="_1 blank"></span>ados,<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">é</span><span class="ls55">\ue003</span></span><span class="lsdc wsbf">chamada<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m0 x9 hd y47 ff6 fs5 fc1 sc0 ls5a wsad">de<span class="ff3 ls6d wsab">\ue003<span class="ff7 lseb wsda">holoe<span class="_2 blank"> </span>nzima<span class="_2 blank"> </span></span></span><span class="ls58">.<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">A</span><span class="ls55">\ue003</span></span><span class="ls5d wsc7">parte<span class="ff3 ls55">\ue003</span><span class="ls68 wsb9">proteica<span class="ff3 ls6d wsab">\ue003</span><span class="ls69 wsdb">dessa<span class="ff3 ls6d wsab">\ue003<span class="_1 blank"></span><span class="ff6 lsd3 wsb0">enzima<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">é</span>\ue003</span><span class="lsd0 wsaa">chamada<span class="ff3 ls6d wsab">\ue003</span><span class="ls5a wsad">de<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x9 hf y48 ff7 fs5 fc1 sc0 lsec wsdc">apoenzima<span class="ff3 ls6d wsab">\ue003<span class="ff6 lsdb wsbe v0">ou</span><span class="ff8 v0">\ue003<span class="_1 blank"></span><span class="ff7 lsed wsdd">apoprote<span class="_1 blank"></span>ína<span class="ff6 ls6d wsb7">.<span class="ff3">\ue003</span></span></span></span></span></div><div class="t m0 x9 hd y49 ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº5]: <span class="_1 blank"></span><span class="ff6 ls6a">E<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">=</span>\ue003</span><span class="lse3 wsde">Enzima<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m0 x9 hd y4a ff6 fs5 fc1 sc0 ls56">S<span class="ff3 ls6d wsab">\ue003</span><span class="ls6d wsb7">=<span class="ff3 wsab">\ue003</span></span><span class="ls5c wsb5">Substrato<span class="ff3 ls6d">\ue003</span></span></div><div class="t m0 x9 hd y4b ff6 fs5 fc1 sc0 ls6d wsb7">P<span class="ff3 wsab">\ue003</span><span class="ls6b">=</span><span class="ff3 wsab">\ue003</span><span class="lsee wsdf">Produt o </span><span class="ff3">\ue003</span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x1 y0 w2 h1" alt="" src="https://files.passeidireto.com/35da187a-909b-4d25-92ce-1983166615f3/bg2.png"><div class="t m0 x1 h5 y4c ff2 fs2 fc0 sc0 ls6d">\ue003</div><div class="t m0 x1 h5 y4d ff2 fs2 fc0 sc0 ls6d">\ue003</div><div class="t m0 x1 h6 y4e ff1 fs2 fc0 sc0 lsef">O<span class="ff2 ls1b">\ue003</span><span class="lsf9 wsc1">estado</span><span class="ff2 ls6d ws4c">\ue003</span><span class="ls8f ws4e">de<span class="ff2 ls1b">\ue003</span></span><span class="lsfa wse0">transição<span class="_1 blank"></span><span class="ff2 ls1b">\ue003<span class="ff1 ls6d wse1">e<span class="ff2 ws4c">\ue003</span>a</span>\ue003<span class="ff1 lsf0 wse2">sua</span>\ue003<span class="ff1 lsfb wse3">importância<span class="_1 blank"></span><span class="ff2 ls1b">\ue003<span class="ff1 ls8f ws4e">na</span>\ue003<span class="ff1 lsfc wse4">reação</span><span class="ls6d ws4c">\ue003<span class="ff1 lsc0 ws95">em</span></span>\ue003<span class="ff1 ls8f ws4e">que</span><span class="ls6d ws4c">\ue003<span class="ff1 wse1">a</span></span>\ue003<span class="ff1 ls49 ws97">enzima</span>\ue003<span class="ff1 lsf1 wse5">está<span class="_1 blank"></span><span class="ff2 ls6d ws4c">\ue003<span class="ff1 lsfd wse6">prese<span class="_1 blank"></span>nte<span class="ff2 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y4f ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls6d ws12">A</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls80 wse7">noção</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls26 ws68">moderna</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls8 wsc">da</span><span class="ls7">\ue003<span class="ff6 ls9 wsd">catálise</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls20 ws48">enzimática</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls8a ws43">diz</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls80 ws2a">que</span>\ue003<span class="ff6 ls6d ws12">a</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls23 ws61">fim</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls80 ws2a">de</span>\ue003<span class="ff6 lsfe wse8">real i z a r</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls8 wsc">uma</span><span class="ls6d ws9">\ue003</span><span class="ff6 lsc ws18">catálise,</span><span class="ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ff6 ls79 ws1b">enzim<span class="_1 blank"></span>a<span class="ff3 ls6d ws9">\ue003</span><span class="ls7d ws24">deve<span class="ff3 ls6d ws9">\ue003</span><span class="ls23 ws61">ser<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m0 x1 h4 y50 ff6 fs1 fc1 sc0 lsff wse9">compleme nt ar<span class="ff3 ls7">\ue003</span><span class="lsc4 wsea">ao <span class="ff3 ls6d ws9">\ue003</span><span class="ls79 ws1b">estado<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">de<span class="ff3 ls6d ws9">\ue003</span><span class="ls81 ws2d">transição.<span class="ff3 ls7">\ue003</span><span class="ls26 ws68">Isso<span class="ff3 ls6d ws9">\ue003</span><span class="lsc ws18">significa<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls89">a<span class="ff3 ls6d ws9">\ue003<span class="_1 blank"></span><span class="ff6 lsf2 wseb">interação<span class="ff3 ls6d ws9">\ue003</span><span class="ls12 ws13">ótima<span class="ff3 ls6d ws9">\ue003</span><span class="ls15 ws39">(por<span class="ff3 ls6d ws9">\ue003</span><span class="ls100 wsec">meio<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">de<span class="ff3 ls6d ws9">\ue003</span><span class="ls26 ws68">ligações<span class="ff3 ls6d ws9">\ue003</span><span class="ls75 ws14">fracas)<span class="ff3 ls6d ws9">\ue003</span><span class="ls101 wsed">entre<span class="ff3 ls6d ws9">\ue003</span><span class="ls11">o<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y51 ff6 fs1 fc1 sc0 ls6f ws26">substrato<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">e<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ls7">\ue003</span><span class="ls1a ws45">enzima<span class="ff3 ls7">\ue003</span><span class="ls72 wsee">ocorrem</span></span><span class="ff3 ws9">\ue003</span><span class="lsc wsef">somente </span><span class="ff3 ws9">\ue003</span><span class="ls80 ws2a">no</span><span class="ff3 ws9">\ue003</span><span class="lsf2 wseb">estado</span><span class="ff3 ws9">\ue003</span><span class="ls80 ws9d">de </span><span class="ff3 ws9">\ue003</span><span class="lsc4 wsf">t ran<span class="_2 blank"> </span>siç ão<span class="_2 blank"> </span>.</span><span class="ff3">\ue003</span></span></span></div><div class="t m0 x1 h4 y52 ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls10 ws25">Segue</span><span class="ls7">\ue003<span class="ff6 lsc4 wsf">abai xo<span class="_2 blank"> </span></span>\ue003<span class="ff6 ls6d ws12">o</span>\ue003<span class="ff6 ls9 wsd">exemplo</span><span class="ls6d ws9 v0">\ue003<span class="ff6 ls7e wsf0">das</span>\ue003<span class="ff6 ls73 wsf">rea ç õ e s </span>\ue003<span class="ff6 ls23 ws61">sem</span><span class="ls7">\ue003</span><span class="ff6 ws12">a</span>\ue003<span class="ff6 ls87 ws3a">presença</span>\ue003<span class="ff6 ls80 ws9d">de</span>\ue003<span class="ff6 ls4c ws36">enzima,</span><span class="ls7">\ue003<span class="ff6 ls84 wsf1">reação</span>\ue003<span class="ff6 ls102 wsf2">com</span>\ue003<span class="ff6 ls75 ws14">uma</span></span>\ue003<span class="ff6 ls8a ws43">suposta</span>\ue003<span class="ff6 ls99 ws62">enzima</span>\ue003<span class="ff6 ls8 wsc">que</span>\ue003<span class="ff6 ls7d ws24">se</span>\ue003</span></span></div><div class="t m0 x1 h4 y53 ff6 fs1 fc1 sc0 lsf3 wsf3">encaixa<span class="ff3 ls6d ws9">\ue003</span><span class="lsf2 wsf4">perfeitamente<span class="ff3 ls6d ws9">\ue003</span><span class="lsc4 wsea">ao<span class="ff3 ls6d ws9">\ue003</span><span class="ls103 wsf5">substrato<span class="ff3 ls6d ws9">\ue003</span><span class="ls1d">e<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">uma<span class="ff3 ls7">\ue003</span><span class="lsc7 wsf6">reação<span class="ff3 ls6d ws9">\ue003</span><span class="ls23 ws61">com<span class="ff3 ls6d ws9">\ue003</span></span></span>uma<span class="ff3 ls6d ws9">\ue003</span><span class="ls4c ws36">enzima<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls7d ws24">se<span class="ff3 ls7">\ue003</span><span class="ls75 ws14">encaixa<span class="ff3 ls6d ws9">\ue003</span></span></span>no<span class="ff3 ls6d ws9">\ue003</span></span></span></span></span></span></span><span class="wseb">estado<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws9d">de<span class="ff3 ls6d ws9">\ue003</span><span class="ls97 ws5b">transição.<span class="ff3 ls7">\ue003</span><span class="ls104 wsf7">No <span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x1 h4 y54 ff6 fs1 fc1 sc0 ls4b ws9a">esquema,<span class="ff3 ls7">\ue003</span><span class="ls80 wsf8">usa<span class="ff3 ls19">\u2010</span><span class="ls7d ws24">se<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ls8a wsf9">ideia<span class="ff3 ls7">\ue003</span><span class="ls8 wsc">de<span class="ff3 ls6d ws9">\ue003</span></span></span></span><span class="ws2a">um<span class="ff3 ls6d ws9">\ue003</span><span class="ls11 wsfa">bastão<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">de<span class="ff3 ls6d ws9">\ue003</span><span class="ls26 ws68">metal<span class="ff3 ls6d ws9">\ue003</span><span class="ls102 wsf2">como<span class="ff3 ls7">\ue003</span><span class="ls81 ws2d">substrato<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">e<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ls14 ws22">sua<span class="ff3 ls7">\ue003</span><span class="ls105 wsfb">quebra<span class="ff3 ls7">\ue003</span><span class="ls23 ws61">como<span class="ff3 ls6d ws9">\ue003</span></span></span></span></span></span></span></span></span></span><span class="wsfc">produto.<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m0 x1 h3 y55 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 xa h3 y56 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 h3 y57 ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 hb y58 ff1 fs3 fc2 sc0 lsf4 wsfd">ATENÇÃO<span class="ff2 ls6d">\ue003</span></div><div class="t m0 x1 h4 y59 ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls6d ws12">A</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls5 wsfe">mesma</span><span class="ls6d ws9">\ue003</span><span class="ff6 lsf ws51">energia</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls80 ws2a">de</span><span class="ls6d ws9">\ue003</span><span class="ff6 lsd ws1e">ligação</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls80 ws2a">que</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls12 ws13">fornece</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls78 ws1a">energia</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls76 ws17">pa<span class="_1 blank"></span>ra<span class="ff3 ls7">\ue003</span><span class="ls89">a<span class="ff3 ls6d ws9">\ue003</span><span class="ls1f ws5c">catálise<span class="ff3 ls6d ws9">\ue003</span><span class="lsf">é<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span><span class="ls7">\ue003</span></span><span class="ls1e ws57">responsável<span class="ff3 ls6d ws9">\ue003</span><span class="ls99 ws62">pela<span class="ff3 ls6d ws9">\ue003</span><span class="ls4c ws36">especific<span class="_1 blank"></span>idade<span class="ff3 ls6d ws9">\ue003</span><span class="ls106 wsff">(a<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y5a ff6 fs1 fc1 sc0 ls106 wsff">habilida<span class="_1 blank"></span>de<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">da<span class="ff3 ls6d ws9">\ue003</span><span class="ls99 ws62">enzima<span class="ff3 ls6d ws9">\ue003</span><span class="ls93 ws54">discrimin<span class="_1 blank"></span>ar<span class="ff3 ls6d ws9">\ue003</span><span class="ls10 ws25">entre<span class="ff3 ls6d ws9">\ue003</span><span class="ls11">o<span class="ff3 ls6d ws9">\ue003</span><span class="lsc7 ws100">substrato<span class="ff3 ls6d ws9">\ue003</span><span class="ls1d">e<span class="ff3 ls6d ws9">\ue003</span><span class="ls107 ws101">outra<span class="ff3 ls6d ws9">\ue003</span><span class="ls21 ws5f">molécula).<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h3 y5b ff3 fs1 fc1 sc0 ls6d">\ue003</div><div class="t m0 x1 h6 y5c ff1 fs2 fc0 sc0 ls8f ws4e">Grupos<span class="ff2 ls1b">\ue003</span><span class="ls91 ws50">Catalíticos<span class="ff2 ls6d ws4c">\ue003</span><span class="lsf5 ws102">Específicos<span class="ff2 ls6d ws4c">\ue003</span><span class="ls108 ws103">co<span class="_1 blank"></span>ntr<span class="_1 blank"></span>ibue<span class="_1 blank"></span>m<span class="ff2 ls1b">\ue003</span><span class="ls109 ws104">para<span class="ff2 ls1b">\ue003</span><span class="ls6d wse1">a<span class="ff2 ls1b">\ue003</span><span class="ls10a ws105">ca<span class="_1 blank"></span>tálise<span class="ff2 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y5d ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls97 ws5b">Uma</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls71 wsb">vez</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls8 wsc">que</span><span class="ls7">\ue003<span class="ff6 ls11">o</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls81 ws2d">substrato</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls70 wsa">se</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls10 ws25">liga</span><span class="ls6d ws9">\ue003<span class="ff6 ls89">à</span>\ue003</span><span class="ff6 ls15 ws39">enzi<span class="_1 blank"></span>ma,<span class="ff3 ls6d ws9">\ue003</span><span class="ls22 ws1c">os<span class="ff3 ls7">\ue003</span><span class="ls1a ws45">grupos<span class="ff3 ls6d ws9">\ue003</span><span class="ls23 ws61">catalític<span class="_1 blank"></span>os<span class="ff3 ls6d ws9">\ue003</span><span class="ls12 ws13">funcionais<span class="ff3 ls6d ws9">\ue003</span><span class="ls10b ws40">auxiliam<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ws9">\ue003</span><span class="ls81 ws2d">quebra<span class="ff3 ls7">\ue003</span><span class="lsf">e<span class="ff3 ls7">\ue003</span></span></span>a<span class="ff3 ws9">\ue003</span><span class="lsd ws1e">formação<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">de</span></span><span class="ff3">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y5e ff6 fs1 fc1 sc0 ls1a ws45">ligações<span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws2a">por<span class="ff3 ls7">\ue003</span><span class="ls5 wsfe">meio<span class="ff3 ls6d ws9">\ue003</span></span>de<span class="ff3 ls6d ws9">\ue003</span><span class="ls7d ws24">variados<span class="ff3 ls6d ws9">\ue003</span><span class="ls23 ws61">mecanismos,<span class="ff3 ls6d ws9">\ue003</span><span class="ls103 ws106">incluindo<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003<span class="ff7 ls9 wsd">catálise</span><span class="ff8">\ue003<span class="ff7 ls10c ws107">ácido</span><span class="ls19">\u2010<span class="ff7 lsc ws18">base</span></span>\ue003<span class="_1 blank"></span><span class="ff7 ls17 ws3b">geral<span class="ff6 ls93">,<span class="ff3 ls7">\ue003</span><span class="ls6d ws12">a<span class="ff3 ws9">\ue003</span></span></span><span class="lsc5 wsef">catálise<span class="ff8 ls7">\ue003</span><span class="ls10d ws108">covalen te<span class="ff3 ls6d ws9">\ue003<span class="ff6 lsf">e</span><span class="ls7">\ue003</span><span class="ff6 ws12">a</span>\ue003</span><span class="ls9 wsd">catálise<span class="ff8 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y5f ff7 fs1 fc1 sc0 ls23 ws61">por<span class="ff8 ls6d ws9">\ue003</span><span class="ls33 ws75">íons<span class="ff8 ls6d ws9">\ue003</span><span class="ls77 ws19">metálicos<span class="ff6 ls20">.<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m0 x1 h10 y60 ffb fs1 fc0 sc0 ls6d ws109">Catálise\ue003ácido\u2010base\ue003geral\ue003</div><div class="t m0 x1 h4 y61 ff3 fs1 fc1 sc0 ls53">\ue003<span class="ff6 ls1f ws5c">Muitas</span><span class="ls6d ws9">\ue003</span><span class="ff6 lsb ws2c">reações</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls10e ws10a">tem</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls21 ws5f">intermediários</span><span class="ls6d ws9">\ue003</span><span class="ff6 ls10f ws10b">carrega<span class="_1 blank"></span>dos<span class="ff3 ls6d ws9">\ue003</span><span class="ls9 wsd">instáveis<span class="ff3 ls6d ws9">\ue003</span><span class="ls8 wsc">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls7e ws10c">tendem<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span>\ue003</span><span class="ls7d ws24">se<span class="ff3 ls7">\ue003</span><span class="ls22 ws1c">transfor<span class="_1 blank"></span>mar<span class="ff3 ls7">\ue003</span><span class="ls97 ws10d">rapidamente<span class="ff3 ls6d ws9">\ue003</span><span class="lse ws1f">em<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y62 ff6 fs1 fc1 sc0 ls8a wsf9">reagentes<span class="ff3 ls6d ws9">\ue003</span><span class="ls12 ws13">constituintes,<span class="ff3 ls7">\ue003</span><span class="ls8b ws10e">impedindo<span class="ff3 ls7">\ue003</span><span class="ls7d ws24">assim<span class="ff3 ls6d ws9">\ue003<span class="ff6 ws12">a</span><span class="ls7">\ue003</span></span><span class="ls81 ws2d">reação.<span class="ff3 ls6d ws9">\ue003</span><span class="lsa ws11">Esses<span class="ff3 ls6d ws9">\ue003</span><span class="ls110 ws10f">intermediários<span class="ff3 ls7">\ue003</span></span></span>po<span class="_2 blank"> </span>dem<span class="ff3 ls6d ws9">\ue003</span><span class="ls23 ws61">ser<span class="ff3 ls6d ws9">\ue003</span><span class="ls18 ws3e">estabi<span class="_1 blank"></span>lizados<span class="ff3 ls7">\ue003</span><span class="lsc ws18">pela<span class="ff3 ls6d ws9">\ue003</span><span class="ls1a ws45">transferência<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y63 ff6 fs1 fc1 sc0 ls94 ws56">(retirada<span class="ff3 ls6d ws9">\ue003</span><span class="ls22 ws1c">ou<span class="ff3 ls6d ws9">\ue003</span>ad<span class="_1 blank"></span>ição)<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">de<span class="ff3 ls6d ws9">\ue003</span><span class="lsf6 ws110">prótons<span class="ff3 ls6d ws9">\ue003</span></span>do<span class="ff3 ls6d ws9">\ue003</span><span class="ls26 ws68">substra<span class="_1 blank"></span>to<span class="ff3 ls6d ws9">\ue003</span><span class="ls22 ws1c">ou<span class="ff3 ls7">\ue003</span><span class="ls80 ws2a">do<span class="ff3 ls6d ws9">\ue003</span><span class="ls78 ws1a">intermediári<span class="_1 blank"></span>o,<span class="ff3 ls6d ws9">\ue003</span><span class="ls76 ws17">para<span class="ff3 ls6d ws9">\ue003</span><span class="ls18 ws3e">formar<span class="_1 blank"></span><span class="ff3 ls7">\ue003<span class="ff6 ls33 ws75">espécies</span><span class="ls6d ws9">\ue003<span class="ff6 ls8 wsc">que</span>\ue003<span class="ff6 ls7d ws24">se</span>\ue003<span class="ff6 ls80 ws38">quebram</span></span>\ue003<span class="ff6 lse ws1f">em</span><span class="ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></div><div class="t m0 x1 h4 y64 ff6 fs1 fc1 sc0 ls11 wsfa">produtos<span class="ff3 ls6d ws9">\ue003</span><span class="ls26 ws68">ma<span class="_1 blank"></span>is<span class="ff3 ls6d ws9">\ue003</span><span class="ls111 ws111">rapida me nte <span class="ff3 ls6d ws9">\ue003</span><span class="ls80 ws2a">que<span class="ff3 ls6d ws9">\ue003</span><span class="ls22 ws1c">os<span class="ff3 ls6d ws9">\ue003</span><span class="ls81 ws112">reagente s.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x9 hd y65 ffa fs5 fc1 sc0 lscf wsc1">Coment<span class="_1 blank"></span>ado [Cacá<span class="_1 blank"></span> Fº6]: <span class="_1 blank"></span><span class="ff6 ls6d wsb7">Em<span class="ff3 wsab">\ue003</span><span class="ls64 wsd3">suma,</span><span class="ff3 wsab">\ue003</span>a<span class="ff3 wsab">\ue003</span><span class="lse9 ws113">catálise</span><span class="ff3 wsab">\ue003</span><span class="ls112 ws114">ácido</span><span class="ff3 wsab">\u2010</span><span class="lsf7 ws115">base</span><span class="ff3">\ue003</span></span></div><div class="t m0 x9 hd y66 ff6 fs5 fc1 sc0 lsd2 ws116">gera l<span class="ff3 ls55">\ue003</span><span class="ws117">re f e re<span class="ff3 ls6d wsab">\u2010</span><span class="ls113 ws118">se<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">a</span><span class="ls55">\ue003</span><span class="ff6 wsb7">transferências</span>\ue003</span><span class="ls5a wsad">de<span class="ff3 ls6d wsab">\ue003</span><span class="lse3 wscb">prótons<span class="ff3 ls6d wsab">\ue003<span class="ff6 wsb7">mediadas</span>\ue003</span><span class="lsd4 wsa1">por<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m0 x9 hd y67 ff6 fs5 fc1 sc0 ls68 wsb9">outras<span class="ff3 ls6d wsab">\ue003</span><span class="lsf8 ws119">classes<span class="ff3 ls6d wsab">\ue003</span><span class="ls5a wsad">de<span class="ff3 ls6d wsab">\ue003</span><span class="ls114 ws11a">moléculas<span class="ff3 ls55">\ue003</span><span class="ls112 ws11b">(como<span class="ff3 ls6d wsab">\ue003</span><span class="lsd4 wsa1">por<span class="ff3 ls6d wsab">\ue003</span><span class="ws11c">exemplo<span class="ff3 ls6d wsab">\ue003</span><span class="lsdb wsbe">os<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m0 x9 hd y68 ff6 fs5 fc1 sc0 ls115 ws11d">aminoácidos).<span class="ff3 ls6d">\ue003</span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi xb y0 w3 h11" alt="" src="https://files.passeidireto.com/35da187a-909b-4d25-92ce-1983166615f3/bg3.png"><div class="t m1 x1 h12 y69 ff3 fs7 fc1 sc0 ls116">\ue003<span class="ff6 ls117 ws11e">No</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls156 ws120">centro </span><span class="ls6d ws11f">\ue003</span><span class="ff6 lsb ws121">ativo</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls157 ws122">de</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">uma</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls12c ws124">enzima,</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">um</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls117 ws11e">certo</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls75 ws125">numero</span><span class="ls118">\ue003<span class="ff6 ls157 ws122">de</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls119 ws126">cadeias</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls11f ws127">laterais</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls157 ws128">de</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls75 ws125">aminoácidos</span>\ue003<span class="ff6 ls157 ws122">pode<span class="_2 blank"> </span></span><span class="ls6d ws11f">\ue003</span><span class="ff6 ws129">atuar</span><span class="ls6d ws11f">\ue003<span class="_1 blank"></span><span class="ff6 ls125 ws12a">tanto<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11a ws12b">como<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x1 h12 y6a ff6 fs7 fc1 sc0 ls157 ws12c">doador<span class="ff3 ls118">\ue003</span><span class="ls158 ws12d">ou<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11b ws12e">aceptor<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls159 ws12f">pr<span class="_1 blank"></span>ótons.<span class="ff3 ls6d ws11f">\ue003</span><span class="ls119 ws126">Esse<span class="ff3 ls6d ws11f">\ue003</span><span class="ls15a ws130">tip<span class="_1 blank"></span>o<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11c ws131">catálise<span class="ff3 ls6d ws11f">\ue003</span><span class="ls15b ws132">ocorre<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">na<span class="_1 blank"></span><span class="ff3 ls118">\ue003<span class="ff6 ls77 ws133">maioria</span>\ue003<span class="ff6 ls15c ws134">das</span><span class="ls6d ws11f">\ue003<span class="ff6 ls15d ws135">enzim<span class="_1 blank"></span>as.<span class="ff3 ls118">\ue003</span><span class="ls15e ws136">De<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11d ws137">fato,<span class="_1 blank"></span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ls15f ws138">as</span>\ue003<span class="ff6 ls160 ws139">tran<span class="_1 blank"></span>sfer<span class="_1 blank"></span>ênci<span class="_1 blank"></span>as<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">de<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m1 x1 h12 y6b ff6 fs7 fc1 sc0 ls123 ws13a">prótons<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">são</span><span class="ls118">\ue003</span></span><span class="ls15f ws138">as<span class="ff3 ls6d ws11f">\ue003</span><span class="ls15c ws12d">reações<span class="ff3 ls6d ws11f">\ue003</span><span class="lsb ws121">bioquímicas<span class="ff3 ls118">\ue003</span><span class="ls11e ws13c">mais<span class="ff3 ls6d ws11f">\ue003</span></span>comuns.<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m1 x1 h13 y6c ffb fs7 fc0 sc0 lsd ws13d">Catálise\ue003Covalente\ue003</div><div class="t m1 x1 h12 y6d ff3 fs7 fc1 sc0 ls116">\ue003<span class="ff6 ls11f ws127">Nesse</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls161 ws13e">tipo</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls157 ws122">de</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls120 ws13f">catálise</span><span class="ls6d ws11f">\ue003<span class="ff6 ls121">é</span>\ue003</span><span class="ff6 ls122 ws140 v0">formada</span><span class="ls6d ws11f v0">\ue003<span class="ff6 ls123 ws13a">uma<span class="_1 blank"></span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">ligação</span>\ue003<span class="ff6 ls124 ws141">covalente</span>\ue003<span class="ff6 ls125 ws12a">transitória</span>\ue003<span class="ff6 ls15d ws135">en<span class="_1 blank"></span>tre<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">a</span>\ue003<span class="_1 blank"></span><span class="ff6 ls133 ws142">enzima<span class="ff3 ls6d ws11f">\ue003</span><span class="ls121">e<span class="ff3 ls6d ws11f">\ue003</span><span class="ls126">o<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws143">substrato.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></div><div class="t m1 x1 h12 y6e ff6 fs7 fc1 sc0 ls75 ws125">Considerando<span class="ff3 ls6d ws11f">\ue003</span><span class="ls162 ws144">ab ai x o <span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">a</span>\ue003</span><span class="ls163 ws145">hidrólise <span class="ff3 ls6d ws11f">\ue003</span><span class="ls164 ws146">quí mi ca<span class="ff3 ls6d ws11f">\ue003</span><span class="ls127 ws147">entre<span class="ff3 ls6d ws11f">\ue003</span><span class="ls123 ws13a">os<span class="ff3 ls6d ws11f">\ue003</span><span class="ls13c ws148">grupos<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">A</span>\ue003</span><span class="ls121">e<span class="ff3 ls118">\ue003</span><span class="ls135 ws149">B:<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m2 xc h14 y6f ff9 fs8 fc1 sc0 ls165 ws14a">\ue723\ued46\ue724<span class="_5 blank"></span>\ue003</div><div class="t m3 xd h15 y70 ff9 fs9 fc1 sc0 ls6d">\uebc1</div><div class="t m4 xe h16 y71 ff9 fsa fc1 sc0 ls6d">\uec2e</div><div class="t m3 xf h15 y70 ff9 fs9 fc1 sc0 ls6d">\uebc8</div><div class="c xd y72 w4 h17"><div class="t m2 x10 h14 y73 ff9 fs8 fc1 sc0 ls6d">\uf231</div></div><div class="c xe y72 w5 h17"><div class="t m2 x11 h14 y73 ff9 fs8 fc1 sc0 ls6d">\ue6db</div></div><div class="c xf y72 w6 h17"><div class="t m2 x11 h14 y73 ff9 fs8 fc1 sc0 ls6d">\uf22e</div></div><div class="t m2 x12 h14 y6f ff9 fs8 fc1 sc0 ls166 ws14b">\ue003\ue723<span class="_6 blank"> </span>\ued45<span class="_6 blank"> </span>\ue724<span class="ff3 ls6d">\ue003</span></div><div class="t m2 x1 h18 y74 ff3 fs8 fc1 sc0 ls128">\ue003<span class="ff6 ls167 ws14c">Na</span><span class="ls6d ws14d">\ue003</span><span class="ff6 ls129 ws14e">presença</span><span class="ls6d ws14d">\ue003</span><span class="ff6 ls168 ws14f">de</span><span class="ls6d ws14d">\ue003</span><span class="ff6 ls168 ws14f">um<span class="_1 blank"></span><span class="ff3 ls6d ws14d">\ue003<span class="ff6 ls169 ws150">catalis ado r </span>\ue003<span class="ff6 ls16a ws151">covalent<span class="_2 blank"> </span>e</span>\ue003<span class="ff6 ls16b wsa1">(uma</span>\ue003<span class="ff6 ls16c ws152">enzima</span>\ue003<span class="ff6 ls16d ws153">com</span>\ue003<span class="ff6 ls12a">o</span>\ue003<span class="ff6 ls16e ws154">nucleofílico</span>\ue003<span class="ff6 ls16f ws155">X:</span>\ue003<span class="ff6 lse3 ws156">),</span>\ue003<span class="ff6 lse1">a</span>\ue003<span class="ff6 ls170 ws157">reação</span>\ue003<span class="ff6 ls171 ws158">ocorre</span>\ue003<span class="ff6 ls169 ws159">da</span>\ue003</span></span></div><div class="t m2 x1 h18 y75 ff6 fs8 fc1 sc0 ls16e ws154">seguinte<span class="ff3 ls6d ws14d">\ue003</span><span class="ls172">forma:</span></div><div class="t m1 x13 h19 y76 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h1a y77 ff9 fs7 fc1 sc0 ls173 ws15a">\ue723\ued46\ue724\ued45\ue73a<span class="_5 blank"></span>:<span class="_5 blank"></span>\ue003<span class="_2 blank"> </span>\u2192<span class="_2 blank"> </span>\ue723\ued46\ue73a\ued45\ue724<span class="_5 blank"></span>\ue003<span class="_5 blank"></span>\ue003</div><div class="t m3 x15 h15 y78 ff9 fs9 fc1 sc0 ls6d">\ue72a</div><div class="t m4 x16 h16 y79 ff9 fsa fc1 sc0 ls6d">2</div><div class="t m3 x17 h15 y78 ff9 fs9 fc1 sc0 ls6d">\ue731</div><div class="t m1 x15 h1a y7a ff9 fs7 fc1 sc0 ls6d">\uf231</div><div class="c x16 y7b w7 h1b"><div class="t m1 x11 h1a y7c ff9 fs7 fc1 sc0 ls6d">\ue6db</div></div><div class="c x17 y7b w8 h1b"><div class="t m1 x11 h1a y7c ff9 fs7 fc1 sc0 ls6d">\uf22e</div></div><div class="t m1 x18 h1a y7a ff9 fs7 fc1 sc0 ls141 ws15b">\ue003\ue003\ue723<span class="_6 blank"> </span>\ued45<span class="_7 blank"> </span>\ue73a:<span class="_7 blank"> </span>\ued45\ue724\ue003<span class="ff3 ls6d">\ue003</span></div><div class="t m1 x1 h12 y7d ff3 fs7 fc1 sc0 ls116">\ue003<span class="ff6 ls124 ws141">Isso</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls174 ws15c">altera</span><span class="ls6d ws11f">\ue003<span class="ff6 ls12b">o</span>\ue003</span><span class="ff6 ls12c ws124">caminho</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">da</span><span class="ls118">\ue003<span class="ff6 ls175 ws15d">reação</span><span class="ls6d ws11f">\ue003<span class="ff6 ls121">e</span></span>\ue003<span class="ff6 ls12c ws124">resulta</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls15b ws132">em</span>\ue003<span class="ff6 ls11e ws13c">catálise</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls176 ws15e">apenas</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls15c ws134">quando<span class="_2 blank"> </span></span><span class="ls6d ws11f">\ue003<span class="ff6 ls126">o</span>\ue003</span><span class="ff6 ls119 ws126">novo</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls177 ws9c">caminho</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls125 ws12a">tem</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls123 ws13a">uma</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls15d ws135">ene<span class="_1 blank"></span>rgia<span class="_1 blank"></span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ls146 ws123">de</span>\ue003</span></span></span></div><div class="t m1 x1 h12 y7e ff6 fs7 fc1 sc0 ls178 ws15f">ativação<span class="ff3 ls118">\ue003</span><span class="ls11f ws127">menor<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">que<span class="ff3 ls118">\ue003</span><span class="ls179 ws160">aquele <span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">da<span class="ff3 ls118">\ue003</span><span class="ls17a ws161">re<span class="_2 blank"> </span>ação <span class="ff3 ls6d ws11f">\ue003</span></span></span></span>não<span class="ff3 ls12d">\u2010</span><span class="ls8a ws162">catalisada.<span class="_2 blank"> </span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls117 ws11e">Assim,<span class="ff3 ls118">\ue003</span><span class="ls158 ws163">os<span class="ff3 ls6d ws11f">\ue003</span><span class="ls75 ws125">dois<span class="ff3 ls6d ws11f">\ue003</span><span class="ls12e ws164">novos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17b ws165">pa<span class="_1 blank"></span>ssos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17c ws2d">precisam<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17d ws166">ser<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11e ws13c">mais<span class="ff3 ls118">\ue003</span><span class="ls17e wsc1">rápidos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">que<span class="ff3 ls6d ws11f">\ue003</span><span class="ls123 ws13a">os<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m1 x1 h12 y7f ff6 fs7 fc1 sc0 ls157 ws122">da<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17f ws167">reação<span class="ff3 ls118">\ue003</span></span>não<span class="_2 blank"> </span><span class="ff3 ls6d ws11f">\u2010</span><span class="ls8a ws162">catalisada.<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x1 h19 y80 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h13 y81 ffb fs7 fc0 sc0 ls119 ws168">Catálise\ue003por\ue003íons\ue003metálicos\ue003</div><div class="t m1 x1 h12 y82 ff3 fs7 fc1 sc0 ls116">\ue003<span class="ff6 ls180 ws67">As</span><span class="ls118">\ue003<span class="ff6 ls181 ws169">interaç õe s</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls120 ws13f">iônicas</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls15d ws135">entre</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls157 ws16a">um</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls182 ws16b">metal</span><span class="ls6d ws11f v0">\ue003<span class="ff6 lsb ws121">ligado</span>\ue003<span class="ff6 ls12f">à</span>\ue003<span class="ff6 ls133 ws142">enzima</span>\ue003<span class="ff6 ls130">e</span>\ue003<span class="ff6 ls126">o</span>\ue003<span class="ff6 ls175 ws15d">substrato</span>\ue003<span class="ff6 ls175 ws15d">podem</span><span class="ls118">\ue003<span class="ff6 ls183 ws16c">ajudar</span>\ue003</span><span class="ff6 ws13b">a</span>\ue003<span class="ff6 ls127 ws147">orientar</span><span class="ls118">\ue003<span class="ff6 ls126">o</span>\ue003<span class="ff6 ls177 ws16d">substrato</span></span>\ue003<span class="ff6 ls184 ws16e">para</span>\ue003</span></span></div><div class="t m1 x1 h12 y83 ff6 fs7 fc1 sc0 ls6d ws13b">a<span class="ff3 ls118">\ue003</span><span class="ls17a ws161">reaç ão </span><span class="ff3 ws11f">\ue003</span><span class="ls123 ws13a">ou<span class="ff3 ls118">\ue003</span><span class="ls131 ws16f">estabilizar</span></span><span class="ff3 ws11f">\ue003</span><span class="ls123 ws13a">os<span class="ff3 ls118">\ue003</span><span class="ls132 ws170">estados</span></span><span class="ff3 ws11f">\ue003</span><span class="ls157 ws128">de</span><span class="ff3 ws11f">\ue003</span><span class="ls133 ws142">transição</span><span class="ff3 ws11f">\ue003</span><span class="ls163 ws60">carregados</span><span class="ff3 ws11f">\ue003</span><span class="ls124 ws141">eletricamente.</span><span class="ff3 ws11f">\ue003</span><span class="lsd ws171">Os</span><span class="ff3 ws11f">\ue003</span><span class="ls124">metais</span><span class="ff3 ws11f">\ue003</span><span class="ls175 ws15d">podem</span><span class="ff3 ws11f">\ue003</span><span class="ls185 ws172">também</span><span class="ff3 ws11f">\ue003</span><span class="ls134 ws173">mediar<span class="_1 blank"></span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ls15c ws12d">reações</span>\ue003</span></span></div><div class="t m1 x1 h12 y84 ff6 fs7 fc1 sc0 ls157 ws128">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls135 ws149">oxido<span class="ff3 ls6d ws11f">\u2010</span><span class="ls119 ws126">redução<span class="ff3 ls6d ws11f">\ue003</span><span class="ls118 ws129">por<span class="ff3">\ue003</span><span class="ls182 ws16b">meio</span><span class="ff3">\ue003</span></span></span></span><span class="ws122">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls8a ws162">mudanças<span class="_2 blank"> </span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls174 ws174">reversíve is<span class="ff3 ls6d ws11f">\ue003</span></span></span>no<span class="ff3 ls6d ws11f">\ue003</span><span class="ls13d ws175">estado<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls186 ws176">oxidação<span class="ff3 ls118">\ue003</span></span></span></span>do<span class="ff3 ls118">\ue003</span><span class="ls135 ws149">íon<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11f ws127">metáli<span class="_1 blank"></span>co.<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m1 x1 h19 y85 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h1c y86 ff1 fsb fc0 sc0 ls187 ws95">Cinética<span class="ff2 ls136">\ue003</span><span class="ls188 ws177">Enzimática<span class="ff2 ls6d">\ue003</span></span></div><div class="t m1 x7 h12 y87 ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> <span class="ff6 ls138">A</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls176 ws106">concentração<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">do</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls139 ws178">substrato</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls189 ws179">afe ta<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="lsf2 ws17a">velocidade </span><span class="ff3 ws11f">\ue003</span><span class="ls146 ws123">das</span><span class="ff3 ws11f">\ue003</span><span class="ls126 ws17b">reações</span><span class="ff3 ws11f">\ue003</span><span class="ls13c ws148">catalisadas</span><span class="ff3 ws11f">\ue003</span><span class="ls157 ws12c">por</span><span class="ff3 ws11f">\ue003</span><span class="ls13a ws17c">enzimas.</span><span class="ff3">\ue003</span></span></span></div><div class="t m1 x7 h12 y88 ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls18a ws17d">Equação<span class="ff3 ls118">\ue003</span><span class="ls157 ws128">de </span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls18b ws17e">Mic<span class="_2 blank"> </span>hael is </span><span class="ff3 ls6d ws11f">\u2010</span><span class="ff6 ls119 ws17f">Me nte n<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x19 h1a y89 ff9 fs7 fc1 sc0 ls13b ws180">\ue727\ued45<span class="_1 blank"></span>\ue735</div><div class="t m1 x1a h1a y8a ff9 fs7 fc1 sc0 ls6d">\ue72d</div><div class="t m5 x1b h1d y8b ff9 fsc fc1 sc0 ls6d">\ueb35</div><div class="t m1 x12 h1a y8c ff9 fs7 fc1 sc0 ls18c">\u2190\u2192</div><div class="t m1 x12 h1a y8d ff9 fs7 fc1 sc0 ls6d">\ue72d</div><div class="t m5 x1c h1d y8e ff9 fsc fc1 sc0 ls18d">\ueb3f\ueb35</div><div class="t m1 x1d h1a y89 ff9 fs7 fc1 sc0 ls13c ws181">\ue003\ue727\ue735\ue003</div><div class="t m5 x1e h1d y8f ff9 fsc fc1 sc0 ls6d">\uebc4</div><div class="t m3 x1f h1e y90 ff9 fsd fc1 sc0 ls6d">\uec2e</div><div class="t m1 x1e h1a y89 ff9 fs7 fc1 sc0 ls6d">\uf231</div><div class="c x1f y91 w9 h1b"><div class="t m1 x20 h1a y92 ff9 fs7 fc1 sc0 ls6d">\uf22e</div></div><div class="t m1 x21 h1a y89 ff9 fs7 fc1 sc0 ls18e ws182">\ue003\ue727 \ued45\ue732<span class="_3 blank"></span><span class="ff3 ls6d">\ue003</span></div><div class="t m1 x7 h12 y93 ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls18f ws183">Descr<span class="_1 blank"></span>eve<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11d ws137">como<span class="ff3 ls6d ws11f">\ue003<span class="_1 blank"></span><span class="ff6 ls12f">a<span class="ff3 ls6d">\ue003</span><span class="ls117 ws184">velocidade</span><span class="ff3 ls6d">\ue003</span><span class="ls146 ws123">da<span class="ff3 ls118">\ue003</span><span class="ls175 ws15d">reação</span></span><span class="ff3 ls6d">\ue003</span><span class="ls146 ws123">pode</span><span class="ff3 ls6d">\ue003</span><span class="ls17c ws2d">variar</span><span class="ff3 ls6d">\ue003</span><span class="ls11d ws137">com</span><span class="ff3 ls6d">\ue003</span>a<span class="ff3 ls6d">\ue003</span><span class="ls176 ws106">concentração<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">do</span></span><span class="ff3 ls6d">\ue003</span><span class="ls132 ws170">substrato<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m1 x22 h1f y94 ff9 fs7 fc1 sc0 ls157 ws185">\ue738\ue74b<span class="_8 blank"> </span>\ued4c \ue003 <span class="ls190 ws186 v3">\ue738\ue749\ue73d\ue754 \ue003.<span class="_7 blank"> </span></span><span class="ls13d v4">\uf23e</span><span class="ls13e v3">\ue735</span><span class="ls6d v4">\uf23f</span></div><div class="t m1 x23 h20 y95 ff9 fs7 fc1 sc0 ls121 ws187">\ue72d\ue749 \ued45 <span class="ls13d v5">\uf23e</span><span class="ls13f">\ue735<span class="ls140 v5">\uf23f</span><span class="ls141 ws188 v6">\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue003<span class="_1 blank"></span>\ue003\ue003\ue003\ue003\ue003\ue003\ue003\ue72d\ue749<span class="_6 blank"> </span>\ued4c \ue003<span class="_7 blank"> </span><span class="ls6d v3">\ue72d</span></span></span></div><div class="t m5 x24 h1d y96 ff9 fsc fc1 sc0 ls18d">\ueb3f\ueb35</div><div class="t m1 x25 h1a y97 ff9 fs7 fc1 sc0 ls191">\ued45\ue72d</div><div class="t m5 x26 h1d y96 ff9 fsc fc1 sc0 ls6d">\ueb36</div><div class="t m1 x27 h1a y98 ff9 fs7 fc1 sc0 ls6d">\ue72d</div><div class="t m5 x28 h1d y99 ff9 fsc fc1 sc0 ls6d">\ueb35</div><div class="t m1 x29 h1a y94 ff9 fs7 fc1 sc0 ls142">\ue003<span class="ff3 ls6d">\ue003</span></div><div class="t m1 x1 h1c y9a ff1 fsb fc0 sc0 ls192 ws189">As<span class="ff2 ls136">\ue003</span><span class="ls193 ws18a">enzim<span class="_2 blank"> </span>as<span class="ff2 ls6d ws18b">\ue003</span><span class="ls194 ws18c">são<span class="ff2 ls136">\ue003</span><span class="ls195 ws18d">sujeitas<span class="ff2 ls136">\ue003</span><span class="ls6d ws18e">à<span class="_1 blank"></span><span class="ff2 ls136">\ue003<span class="ff1 ls196 ws18f">inibição</span><span class="ls6d">\ue003</span></span></span></span></span></span></div><div class="t m1 x7 h12 y9b ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls197 ws190">As</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls143 ws191">inibições</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls157 ws128">podem<span class="ff3 ls118">\ue003</span><span class="ls11d ws137">ser</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls11c ws131">reversíveis</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls123 ws13a">ou</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 lsd ws192">irreversíveis<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 xb h12 y9c ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 lsd ws171">Os</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls11e ws13c">inibidores<span class="ff3 ls118">\ue003</span><span class="ls143 ws191">enzimáticos</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls17d ws166">são<span class="ff3 ls118">\ue003</span><span class="ls162 ws193">agente s </span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls145 ws194">moleculares</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">que</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls11c ws131">interferem</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls157 ws122">na<span class="ff3 ls118">\ue003</span><span class="ls120 ws13f">catálise.<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m1 x7 h12 y9d ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls77 ws133">Inibição</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls133 ws142">Reversível<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 xb h12 y9e ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls11f ws127">Competitiva<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x1 h19 y9f ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m6 x2a h21 ya0 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2a h21 ya1 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2a h22 ya2 ff6 fse fc3 sc0 ls198 ws195">Uma<span class="ff3 ls6d ws196">\ue003</span><span class="ls199 ws197">inibiç<span class="_1 blank"></span>ão<span class="ff3 ls6d ws196">\ue003</span><span class="ls19a ws198">competitiva<span class="ff3 ls147">\ue003</span><span class="ls14b ws199">que<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws153">pode<span class="ff3 ls6d ws196">\ue003</span><span class="ls148 ws19a">ser<span class="ff3 ls147">\ue003</span><span class="ls19b ws19b">usada<span class="ff3 ls6d ws196">\ue003</span></span></span></span>de<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws153">exe<span class="_2 blank"> </span>mplo<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">é</span>\ue003</span></span></span></span></span></div><div class="t m6 x2a h22 ya3 ff6 fse fc3 sc0 ls6d ws19c">o<span class="ff3 ws196">\ue003</span><span class="ls149 ws19d">tratamento</span><span class="ff3 ws196">\ue003</span><span class="ls19c ws11d">com</span><span class="ff3 ws196">\ue003</span><span class="ls14a ws19e">pacientes</span><span class="ff3 ws196">\ue003</span><span class="ls14b ws199">que</span><span class="ff3 ws196">\ue003</span><span class="ls19d ws19f">ingeriram<span class="ff3 ls147">\ue003</span><span class="ls19e ws1a0">metanol . </span></span><span class="ff3 ws196">\ue003</span><span class="ls19f ws1a1">Dá</span><span class="ff3 ws196">\u2010</span><span class="ls1a0 ws1a2">se</span><span class="ff3">\ue003</span></div><div class="t m6 x2a h22 ya4 ff6 fse fc3 sc0 ls68 ws1a3">ao<span class="ff3 ls6d ws196">\ue003</span><span class="ls14c ws1a4">paciente<span class="ff3 ls6d ws196">\ue003</span><span class="ls6a ws1a5">etanol,<span class="ff3 ls6d ws196">\ue003</span><span class="ls19b ws1a6">que<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">irá<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a0 ws1a2">se<span class="ff3 ls6d ws196">\ue003</span></span>ligar<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">no<span class="ff3 ls147">\ue003</span><span class="ls1a2 wsc4">lugar<span class="ff3 ls6d ws196">\ue003</span></span>do<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws1a8">metanol.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m1 x1 h19 ya5 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 ya6 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 ya7 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 ya8 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 xb h12 ya9 ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls75 ws125">Não<span class="ff3 ls118">\ue003</span><span class="ls11f ws127">competitiva<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m1 x1 h19 yaa ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m6 x2b h21 yab ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2b h21 yac ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2b h22 yad ff6 fse fc3 sc0 ls198 ws195">Um<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a3 ws1a9">inibidor<span class="ff3 ls6d ws196">\ue003</span><span class="ls14d ws1aa">não<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">com<span class="_1 blank"></span>petitivo<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a4 ws1ab">(também<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws153">chamado<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">de<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a5 ws1ac">incompetitivo)<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a0 ws1a2">se<span class="ff3 ls6d ws196">\ue003</span></span></span></span></span></span>liga<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m6 x2b h22 yae ff6 fse fc3 sc0 ls1a6 ws1ad">em<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">um<span class="ff3 ls6d ws196">\ue003</span><span class="ls14e ws1ae">sítio<span class="ff3 ls6d ws196">\ue003</span><span class="ls14f ws1af">dif<span class="_1 blank"></span>erente<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">do<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a7 ws1b0">sítio<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a8 ws1b1">at i v o <span class="ff3 ls6d ws196">\ue003</span></span></span>do<span class="ff3 ls6d ws196">\ue003</span><span class="ls150 ws1b2">substrato,<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">porém,<span class="ff3 ls6d ws196">\ue003</span><span class="ls149 ws19d">diferente<span class="ff3 ls6d ws196">\ue003</span></span></span></span>do<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m6 x2b h22 yaf ff6 fse fc3 sc0 ls1a9 ws1b4">inibidor <span class="ff3 ls6d ws196">\ue003</span><span class="ws1b5">comp etitiv o, <span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">liga<span class="ff3 ls6d ws196">\u2010</span><span class="ls1a7 ws1b6">se<span class="ff3 ls6d ws196">\ue003</span><span class="ls6a ws1a5">apenas<span class="ff3 ls6d ws196">\ue003</span><span class="ls68 ws1a3">ao<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a5 ws1b7">complexo<span class="ff3 ls6d ws196">\ue003</span><span class="ls151 ws1b8">ES.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m1 x1 h19 yb0 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 yb1 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 yb2 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 yb3 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 yb4 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 yb5 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m6 x9 h22 yb6 ffa fse fc1 sc0 ls1aa wsc1">Comentad<span class="_1 blank"></span>o [Cacá <span class="_1 blank"></span>Fº7]: <span class="ff6 ls1ab ws1b9">Quanto<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">menor<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">o</span>\ue003</span><span class="ls1ac ws1ba">Km,<span class="ff3 ls6d ws196">\ue003<span class="_1 blank"></span><span class="ff6 lsd0 ws1bb">mais<span class="ff3 ls147">\ue003</span><span class="ls68 ws1a3">rápida<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m6 x9 h22 yb7 ff6 fse fc1 sc0 ls14d ws1aa">será<span class="ff3 ls152">\ue003</span><span class="ls68">a<span class="ff3 ls6d ws196">\ue003</span><span class="lsd0">reação</span></span></div><div class="t m6 x2c h21 yb8 ff3 fse fc1 sc0 ls6d">\ue003</div><div class="t m6 x9 h22 yb9 ffa fse fc1 sc0 ls1aa wsc1">Comentad<span class="_1 blank"></span>o [Cacá <span class="_1 blank"></span>Fº8]: <span class="ff6 ls14b ws1bc">Ing<span class="_1 blank"></span>estão<span class="ff3 ls6d ws196">\ue003</span><span class="ws199">de<span class="ff3 ls6d ws196">\ue003</span><span class="ls19e ws1a0">meta n o l <span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">irá<span class="ff3 ls6d ws196">\ue003</span><span class="ls1ad ws1bd">formar<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m6 x9 h22 yba ff6 fse fc1 sc0 ls153 ws1be">formaldeído,<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">que<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">irá<span class="ff3 ls6d ws196">\ue003</span></span>causar<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">cegu<span class="_1 blank"></span>eira.<span class="ff3 ls6d ws196">\ue003</span><span class="ls1ae ws1bf">Ao<span class="ff3 ls6d ws196">\ue003</span><span class="ls1af ws1c0">administrar<span class="ff3 ls147">\ue003</span><span class="ls1b0 ws1b6">etan ol <span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m6 x9 h22 ybb ff6 fse fc1 sc0 ls14b ws199">no<span class="ff3 ls147">\ue003</span><span class="ls6d ws19c">paciente,<span class="ff3 ws196">\ue003</span><span class="ls68">a</span><span class="ff3 ws196">\ue003</span><span class="lsd0 ws1bb">enzima</span><span class="ff3 ws196">\ue003</span><span class="ls1a4 ws1c1">irá<span class="ff3 ls147">\ue003</span><span class="ls1b1 ws1c2">conve r t<span class="_2 blank"> </span>er</span></span><span class="ff3 ws196">\ue003</span>o<span class="ff3 ls147">\ue003</span><span class="lsd3 ws1b3">produto<span class="ff3 ls147">\ue003</span><span class="ls1b2 ws1c3">final</span></span><span class="ff3 ws196">\ue003</span><span class="ls6a ws1a5">em</span><span class="ff3">\ue003</span></span></div><div class="t m6 x9 h22 ybc ff6 fse fc1 sc0 lsd0 ws1c4">acetaldeído,<span class="ff3 ls6d ws196">\ue003</span><span class="ls154 ws1c5">enquanto<span class="ff3 ls6d ws196">\ue003</span><span class="ls1b3 ws1c6">os<span class="ff3 ls6d ws196">\ue003</span><span class="ls1b4 ws1c7">rins<span class="ff3 ls6d ws196">\ue003</span><span class="ls1b5 ws1c8">secretam<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">o</span>\ue003</span><span class="ls14b ws199">metanol<span class="ff3 ls6d ws196">\ue003</span><span class="ls1af ws1c0">para<span class="ff3 ls6d ws196">\ue003</span><span class="ls68">a<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m6 x9 h22 ybd ff6 fse fc1 sc0 ls150 ws1b2">urina,<span class="ff3 ls6d ws196">\ue003</span><span class="ls68 ws1a3">evitando<span class="ff3 ls6d ws196">\ue003</span><span class="ls155 ws1c9">assim<span class="ff3 ls6d ws196">\ue003</span></span>a<span class="ff3 ls6d ws196">\ue003</span><span class="lsd0 ws1bb">cegueira.<span class="ff3 ls6d">\ue003</span></span></span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x1 y0 w2 h11" alt="" src="https://files.passeidireto.com/35da187a-909b-4d25-92ce-1983166615f3/bg4.png"><div class="t m1 x1 h19 y69 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 xb h12 ybe ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls124 ws141">Mista<span class="ff3 ls6d">\ue003</span></span></div><div class="t m6 x1 h21 ybf ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x1 h21 yc0 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x1 h21 yc1 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x1 h21 yc2 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x1 h21 yc3 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2d h22 yc4 ff6 fse fc3 sc0 ls198 ws195">Um<span class="ff3 ls6d ws196">\ue003</span><span class="ls1b6 ws1ca">inibidor<span class="_1 blank"></span><span class="ff3 ls147">\ue003<span class="ff6 ls1cb ws1cb">misto</span><span class="ls6d ws196">\ue003<span class="ff6 ws19c">é</span>\ue003<span class="ff6 ls1b7 ws1cc">aquele</span>\ue003<span class="ff6 ls14b ws199">que</span>\ue003<span class="ff6 ls154 ws1c5">também</span>\ue003<span class="ff6 ls1a0 ws1a2">se</span>\ue003<span class="ff6 ls1a1 ws1a7">liga</span>\ue003<span class="ff6 ls68">a</span>\ue003<span class="ff6 ls14b ws199">um</span>\ue003<span class="ff6 ls14e ws1ae">sítio</span>\ue003</span></span></span></div><div class="t m6 x2d h22 yc5 ff6 fse fc3 sc0 ls149 ws19d">diferente<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">do<span class="ff3 ls6d ws196">\ue003</span><span class="ls1cc ws1cd">sítio<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a2 ws1ce">ativo<span class="ff3 ls6d ws196">\ue003</span></span></span>do<span class="ff3 ls147">\ue003</span><span class="ls5b ws1cf">substrato,<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">porém,<span class="ff3 ls6d ws196">\ue003</span><span class="ls1cd ws1d0">ele<span class="ff3 ls6d ws196">\ue003</span></span></span><span class="ws153">pode<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a0 ws1a2">se<span class="ff3 ls6d ws196">\ue003</span><span class="ls1ce ws1d1">ligar<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m6 x2d h22 yc6 ff6 fse fc3 sc0 ls1b5 ws1c8">tanto<span class="ff3 ls6d ws196">\ue003</span><span class="ls68">a<span class="ff3 ls6d ws196">\ue003</span><span class="ls151">E<span class="ff3 ls6d ws196">\ue003</span><span class="ls1cf ws1d2">como<span class="ff3 ls6d ws196">\ue003</span></span></span><span class="ws1a3">ao<span class="ff3 ls6d ws196">\ue003</span><span class="ls1cf ws1d2">complexo<span class="ff3 ls147">\ue003</span><span class="ls1d0 ws1d3">ES.<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m6 x2d h21 yc7 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2d h21 yc8 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2d h21 yc9 ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x2d h21 yca ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m6 x1 h21 ycb ff3 fse fc3 sc0 ls6d">\ue003</div><div class="t m1 x2 h12 ycc ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls117 ws11e">Irreversível<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x7 h12 ycd ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls120 ws13f">Inibidores</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 lsd ws192">irreversíveis</span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">são</span>\ue003</span><span class="ff6 ls119 ws126">aqueles<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">que</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1b8 ws1d4">se<span class="_2 blank"> </span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 lsd ws171">ligam<span class="ff3 ls118">\ue003</span><span class="ls1d1 ws1d5">com</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">um</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls183 ws16c">grupo</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1d2 ws16a">funcion al <span class="ff3 ls118">\ue003</span><span class="ls157 ws122">da<span class="ff3 ls118">\ue003</span><span class="ls11d ws137">molécula</span></span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">da</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls15d ws135">enzim<span class="_1 blank"></span>a<span class="ff3 ls6d ws11f">\ue003</span><span class="ls123 ws13a">ou<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m1 x2e h12 yce ff6 fs7 fc1 sc0 ls126">o<span class="ff3 ls6d ws11f">\ue003</span><span class="ls77 ws1d6">destroem</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls123 ws13a">ou</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls176 ws106">ainda</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls189 ws1d7">form<span class="_2 blank"> </span>am</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws17d">uma<span class="ff3 ls118">\ue003</span></span><span class="lsd ws171">associação</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls132 ws170">covalente</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls175 ws15d">bastante</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls15d ws135">estável<span class="_1 blank"></span>,<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1d3 ws1d8">combin an d o<span class="ff3 ls12d">\u2010</span><span class="ls1b8 ws1d4">se<span class="_2 blank"> </span><span class="ff3 ls6d ws11f">\ue003</span><span class="ls15e ws136">assim<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x2e h12 ycf ff6 fs7 fc1 sc0 ls175 ws1d9">irreversivelmente<span class="ff3 ls118">\ue003</span><span class="ls1d1 ws1d5">co m <span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="ls15d ws135">enzim<span class="_1 blank"></span>a.<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m1 x7 h12 yd0 ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls120 ws13f">Inibidores</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1d1 ws1d5">com</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls125 ws12a">base</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls157 ws122">no</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1d4 ws1da">mecanism<span class="_1 blank"></span>o<span class="ff3 ls118">\ue003</span><span class="ls183 ws146">(também<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1d5 ws1db">chamados<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls190 ws1dc">\u201cinibidores<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17d ws166">sui<span class="_1 blank"></span>cida<span class="_1 blank"></span>s\u201d)<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">são<span class="ff3 ls118">\ue003</span><span class="lsf2 ws1dd">aqueles</span><span class="ff3 ws11f">\ue003</span><span class="ls157 ws122">que</span><span class="ff3">\ue003</span></span></span></span></span></span></span></span></div><div class="t m1 x2e h12 yd1 ff6 fs7 fc1 sc0 ls117 ws11e">participam<span class="ff3 ls6d ws11f">\ue003</span><span class="ls118 ws129">dos<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">primeiros</span><span class="ls118">\ue003</span></span><span class="ls157 ws143">passos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1d6 ws145">quími cos</span></span><span class="ff3">\ue003</span><span class="ls157 ws122">da</span><span class="ff3">\ue003</span><span class="ls175 ws16a">reação <span class="ff3 ls6d ws11f">\ue003</span><span class="ls145 ws194">enzimática<span class="ff3 ls6d ws11f">\ue003</span></span></span>normal,<span class="ff3">\ue003</span><span class="lsb ws121">mas</span><span class="ff3">\ue003</span><span class="ls1b8 ws1d4">são<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1d7 ws1de">desenha<span class="_1 blank"></span>dos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">de<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x2e h12 yd2 ff6 fs7 fc1 sc0 ls12c ws124">modo<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">que<span class="ff3 ls6d ws11f">\ue003</span><span class="ls17d ws166">se<span class="ff3 ls6d ws11f">\ue003</span><span class="ls75 ws125">ligam<span class="ff3 ls6d ws11f">\ue003</span></span></span>de<span class="ff3 ls118">\ue003</span><span class="ls1d8 ws1df">forma<span class="ff3 ls118">\ue003</span><span class="ls131 ws16f">irreversível<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">a</span>\ue003</span></span></span></span>enzima.<span class="ff3 ls118">\ue003</span><span class="ls11e ws13c">Portanto,<span class="ff3 ls6d ws11f">\ue003</span><span class="ls15d ws135">eles<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1b8 ws1d4">se<span class="ff3 ls6d ws11f">\ue003</span><span class="lsd ws171">utilizam<span class="ff3 ls118">\ue003</span><span class="ls146 ws123">do<span class="_1 blank"></span><span class="ff3 ls6d ws11f">\ue003<span class="ff6 ls11f ws127">mecanismo</span>\ue003<span class="ff6 ls157 ws128">de</span>\ue003</span></span></span></span></span></span></div><div class="t m1 x2e h12 yd3 ff6 fs7 fc1 sc0 ls175 ws15d">reação<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11f ws127">enzimática<span class="ff3 ls6d ws11f">\ue003</span><span class="ls118 ws129">normal<span class="ff3">\ue003</span><span class="ls1d9 ws1e0">para<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1da ws1e1">ina<span class="_1 blank"></span>tivar<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="ls1db ws1e2">enz<span class="_1 blank"></span>ima.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m1 x1 h19 yd4 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h1c yd5 ff1 fsb fc0 sc0 ls192 ws189">As<span class="ff2 ls136">\ue003</span><span class="ls193 ws18a">enzim<span class="_2 blank"> </span>as<span class="ff2 ls6d ws18b">\ue003</span><span class="ls8f ws1e3">dependem<span class="ff2 ls6d ws18b">\ue003</span><span class="ls1dc ws1e4">do<span class="ff2 ls136">\ue003</span><span class="lsfb ws1e5">pH<span class="ff2 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x1 h12 yd6 ff3 fs7 fc1 sc0 ls116">\ue003<span class="ff6 ls180 ws67">As</span><span class="ls118">\ue003<span class="ff6 ls119 ws126">enzimas</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls185 ws172">tem</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls11d ws137">seu</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls1b8 ws1d4">valor</span>\ue003<span class="ff6 ls146 ws123">de</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls157 ws122">pH</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls159 ws12f">ótimo,</span><span class="ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">no<span class="_1 blank"></span><span class="ff3 ls118">\ue003<span class="ff6 ls157 ws122">qual,</span><span class="ls6d ws11f">\ue003<span class="ff6 ls11d ws137">com</span>\ue003<span class="ff6 ls123 ws13a">determinado</span>\ue003<span class="ff6 ls119 ws126">valor,</span>\ue003<span class="ff6 ls133 ws142">estarã<span class="_1 blank"></span>o<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">no<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1b8 ws1d4">seu<span class="ff3 ls6d ws11f">\ue003</span><span class="ls8a ws162">ápice<span class="ff3 ls118">\ue003</span></span></span><span class="ws128">de<span class="ff3 ls6d ws11f">\ue003</span></span>produç<span class="_2 blank"> </span>ão<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m1 x1 h12 yd7 ff6 fs7 fc1 sc0 ls12c ws124">catalítica.<span class="ff3 ls6d">\ue003</span></div><div class="t m1 x1 h19 yd8 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h1c yd9 ff1 fsb fc0 sc0 lsfb ws1e5">Regulação<span class="ff2 ls1b9">\ue003</span>da<span class="ff2 ls136">\ue003</span><span class="ls8f ws1e3">atividade<span class="ff2 ls136">\ue003</span><span class="ls1ba ws1e6">enzimá<span class="_1 blank"></span>tica<span class="ff2 ls6d">\ue003</span></span></span></div><div class="t m1 x2 h12 yda ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls6d ws13b">É<span class="ff3 ws11f">\ue003</span><span class="ls120 ws13f">essencial<span class="ff3 ls118">\ue003</span><span class="ls1d9 ws1e0">para</span></span><span class="ff3 ws11f">\ue003</span><span class="ls126">o<span class="ff3 ls118">\ue003</span></span></span><span class="ff6 ws1e7">metabolismo,<span class="ff3 ls118">\ue003</span><span class="ls134 ws173">coord<span class="_1 blank"></span>enar<span class="ff3 ls6d ws11f">\ue003</span><span class="ls123 ws13a">os<span class="ff3 ls118">\ue003</span><span class="ls11c ws131">processos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls11f ws127">metabólicos;<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m1 x2 h12 ydb ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls6d ws16d">Moduladores<span class="ff3 ws11f">\ue003</span><span class="ls75 ws125">alostéricos<span class="ff3 ls118">\ue003</span><span class="ls121">e</span></span><span class="ff3 ws11f">\ue003</span><span class="ls11d ws137">efetores</span><span class="ff3 ws11f">\ue003</span><span class="ls75 ws125">alostéricos</span><span class="ff3">\ue003</span></span></div><div class="t m5 x25 h23 ydc ff7 fsc fc1 sc0 ls1dd ws1e8">C=<span class="ff8 ls1bb">\ue003</span><span class="ls1de ws1e9">subuni<span class="_2 blank"> </span>dade<span class="ff8 ls1bb">\ue003</span><span class="ls1df ws1ea">catalític<span class="_2 blank"> </span>a<span class="ff8 ls6d">\ue003</span></span></span></div><div class="t m5 x14 h23 ydd ff8 fsc fc1 sc0 ls1bc ws1eb">\ue003<span class="_9 blank"></span>\ue003\ue003\ue003\ue003\ue003\ue003<span class="ff7 ls1e0 ws1ec">R=</span><span class="ls6d ws1ed">\ue003<span class="ff7 ls1e1 ws1ee">subunidade</span><span class="ls1bb">\ue003<span class="ff7 ls1e2 ws1ef">re<span class="_1 blank"></span>guladora<span class="ff8 ls6d">\ue003</span></span></span></span></div><div class="t m1 x14 h19 yde ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m6 x14 h22 ydf ff6 fse fc3 sc0 ls149 ws19d">Quando<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">o</span>\ue003</span><span class="ls14d ws1aa">modulador<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a0 ws1a2">se<span class="ff3 ls6d ws196">\ue003</span><span class="ls1ad ws1f0">liga,<span class="ff3 ls6d ws196">\ue003</span><span class="ls1bd">a<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws153">subunidade<span class="ff3 ls6d ws196">\ue003</span><span class="ls1be ws1f1">catalítica<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">começa<span class="ff3 ls6d ws196">\ue003</span><span class="ls68">a<span class="ff3 ls6d ws196">\ue003</span><span class="ls1ab ws1f2">se<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">ligar<span class="ff3 ls6d ws196">\ue003</span></span></span><span class="ws1a3">ao<span class="ff3 ls6d ws196">\ue003</span><span class="ls14c ws1f3">substrato<span class="ff3 ls147">\ue003</span><span class="ls1b1 ws1f4">com<span class="ff3 ls6d ws196">\ue003</span><span class="ls14a ws19e">alta<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></span></span></div><div class="t m6 x14 h22 ye0 ff6 fse fc3 sc0 ls1e3 ws1f5">afinidad<span class="_1 blank"></span>e.<span class="ff3 ls6d ws196">\ue003</span><span class="ls14c ws1f3">Quando<span class="ff3 ls6d ws196">\ue003</span><span class="ls1e4 wsc1">ocorre<span class="ff3 ls6d ws196">\ue003</span><span class="ls68">a<span class="ff3 ls6d ws196">\ue003</span><span class="ls14a ws19e">dissociação<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">do<span class="ff3 ls6d ws196">\ue003</span>modulador<span class="ff3 ls6d ws196">\ue003</span>da<span class="ff3 ls6d ws196">\ue003</span><span class="ls14d ws1aa">subunidade<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">reguladora,<span class="ff3 ls147">\ue003</span></span></span></span></span>a<span class="ff3 ls6d ws196">\ue003</span><span class="ws1a3">enzima<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m6 x14 h22 ye1 ff6 fse fc3 sc0 ls6d ws19c">reverte<span class="ff3 ws196">\ue003</span><span class="lsd3 ws1b3">para</span><span class="ff3 ws196">\ue003</span><span class="ls68">a<span class="ff3 ls147">\ue003</span><span class="ls1a7 ws1f6">sua</span></span><span class="ff3 ws196">\ue003</span><span class="ls19f ws1a1">forma</span><span class="ff3 ws196">\ue003</span><span class="ls5b ws153">menos</span><span class="ff3 ws196">\ue003</span><span class="ls1e5 ws1f7">ativa</span><span class="ff3 ws196">\ue003</span><span class="ls1e6 ws1f8">(ou</span><span class="ff3 ws196">\ue003</span><span class="ls1a8 ws1b1">até</span><span class="ff3 ws196">\ue003</span><span class="ls19e ws1f9">mesm o </span><span class="ff3 ws196">\ue003</span><span class="ls1ad ws1fa">inativa). </span><span class="ff3">\ue003</span></div><div class="t m1 x14 h19 ye2 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h19 ye3 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h19 ye4 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h19 ye5 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h19 ye6 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x14 h19 ye7 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x1 h19 ye8 ff3 fs7 fc1 sc0 ls6d">\ue003</div><div class="t m1 x2 h12 ye9 ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls77 ws133">Inibição<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">por</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls160 ws139">feedba<span class="_1 blank"></span>ck<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x7 h12 yea ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls164 ws1fb">Quando<span class="ff3 ls118">\ue003</span><span class="ls157 ws122">um<span class="ff3 ls118">\ue003</span>produto<span class="_2 blank"> </span></span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">de</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls123 ws13a">uma<span class="ff3 ls118">\ue003</span><span class="ls175 ws15d">reação</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls15e ws136">chega<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="ls123 ws13a">uma</span><span class="ff3 ws11f">\ue003</span><span class="ls176 ws1fc">determinada</span><span class="ff3 ws11f">\ue003</span><span class="lsb ws121">concentração</span><span class="ff3 ws11f">\ue003</span><span class="ls121">e<span class="ff3 ls118">\ue003</span><span class="ls13c ws148">assim,<span class="ff3 ls118">\ue003</span></span></span>a<span class="ff3 ws11f">\ue003</span><span class="ls117 ws11e">enzima</span><span class="ff3 ws11f">\ue003</span><span class="ls1e7 ws1fd">para</span><span class="ff3">\ue003</span></span></span></div><div class="t m1 x2e h12 yeb ff6 fs7 fc1 sc0 ls157 ws128">de<span class="ff3 ls6d ws11f">\ue003</span><span class="ls18a ws1fe">produzi<span class="ff3 ls12d">\u2010</span><span class="ls132 ws1ff">lo <span class="ff3 ls6d ws11f">\ue003</span></span><span class="ws12d">(ref e re<span class="ff3 ls6d ws11f">\u2010</span><span class="ls1b8 ws1d4">se<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">a</span><span class="ls118">\ue003</span></span><span class="lsb ws200">necessidade<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1e8 ws201">ce<span class="_2 blank"> </span>lular <span class="ff3 ls118">\ue003</span><span class="ls15c ws134">para<span class="ff3 ls118">\ue003</span><span class="ls1e9 ws202">re to mar<span class="ff3 ls6d ws11f">\ue003<span class="ff6 ws13b">a</span>\ue003</span><span class="ls177 ws203">pro dução) .<span class="ff3 ls1ea">\ue003\ue003</span></span></span></span></span></span></span></span></span></div><div class="t m1 x2 h12 yec ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls77 ws133">Modificação<span class="ff3 ls118">\ue003</span><span class="ls1bf ws204">covalente</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls15e ws136">reversível<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x7 h12 yed ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls1e9 ws205">Em<span class="ff3 ls118">\ue003</span><span class="lsd ws171">uma</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls123 ws13a">outra<span class="ff3 ls118">\ue003</span><span class="ls11e ws13c">classe<span class="ff3 ls118">\ue003</span><span class="ls174 ws206">importante</span></span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls157 ws128">de </span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls119 ws126">enzimas</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1eb ws167">regulad o ras,<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="ls11d ws137">atividade</span><span class="ff3 ws11f v0">\ue003<span class="ff6 ls121">é</span>\ue003<span class="ff6 lsb ws121">regulada</span>\ue003<span class="ff6 ls146 ws123">por</span>\ue003</span></span></span><span class="ff6 ws124 v0">modificação<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x2e h12 yee ff6 fs7 fc1 sc0 ls139 ws178">covalente<span class="ff3 ls6d ws11f">\ue003</span><span class="ls157 ws122">da<span class="ff3 ls118">\ue003</span><span class="ls145 ws194">molécula<span class="ff3 ls6d ws11f">\ue003</span><span class="ls146 ws123">da<span class="ff3 ls118">\ue003</span><span class="ls1db ws1e2">enzi<span class="_1 blank"></span>ma.<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x7 h12 yef ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls18a ws1fe">Entre<span class="ff3 ls118">\ue003</span><span class="ls158 ws163">os</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 lsb ws121">grupos</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls8a ws162">modific<span class="_2 blank"> </span>adores<span class="ff3 ls118">\ue003</span><span class="ls161 ws13e">estão:</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1c0 ws207">fosfato,<span class="ff3 ls118">\ue003</span><span class="ls162 ws208">adenosi n a<span class="_2 blank"> </span></span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1ec ws209">monofo<span class="_2 blank"> </span>sfato,</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1ed ws20a">uridila<span class="ff3 ls118">\ue003</span><span class="ls139 ws178">monofosfato,<span class="ff3 ls6d">\ue003</span></span></span></div><div class="t m1 x2e h12 yf0 ff6 fs7 fc1 sc0 ls178 ws15f">adenosina<span class="ff3 ls6d ws11f">\ue003</span><span class="ls15e ws136">difosfato<span class="ff3 ls6d ws11f">\ue003</span><span class="ls75 ws125">ribose<span class="ff3 ls6d ws11f">\ue003</span><span class="ls121">e<span class="ff3 ls118">\ue003</span><span class="ls132 ws170">grupos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls1c0 ws207">metila.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m1 x7 h12 yf1 ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls17c ws20b">Esses</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls15c ws134">grupos<span class="ff3 ls118">\ue003</span><span class="ls145 ws194">geralmente</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1ee ws20c">são<span class="_2 blank"> </span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls12d ws1e7">ligados</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls15d ws135">cov<span class="_1 blank"></span>ale<span class="_1 blank"></span>ntemen<span class="_1 blank"></span>te<span class="ff3 ls6d ws11f">\ue003<span class="_1 blank"></span><span class="ff6 ls121">e<span class="ff3 ls6d">\ue003</span><span class="ls119 ws126">removidos</span><span class="ff3 ls6d">\ue003</span><span class="ls157 ws122">da</span><span class="ff3 ls6d">\ue003</span><span class="ls133 ws142">enzima<span class="ff3 ls118">\ue003</span><span class="ls15b ws132">reguladora</span></span><span class="ff3 ls6d">\ue003</span><span class="ls157 ws12c">por</span><span class="ff3 ls6d">\ue003</span><span class="ls186 ws176">ou<span class="_1 blank"></span>tras<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m1 x2e h12 yf2 ff6 fs7 fc1 sc0 ls133 ws142">enzimas.<span class="ff3 ls6d">\ue003</span></div><div class="t m1 x7 h24 yf3 ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls180 ws67">As<span class="ff3 ls118">\ue003</span><span class="ls127 ws147">fosforilaç<span class="_1 blank"></span>ões<span class="ff3 ls6d ws11f">\ue003</span><span class="lsb ws20d">representam<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3 ws11f">\ue003</span><span class="ls1ef ws20e">grand<span class="_1 blank"></span>e<span class="ff3 ls118">\ue003</span><span class="ls1f0 ws20f">maioria<span class="ff3 ls118">\ue003</span><span class="ls15c ws210">das<span class="ff3 ls118">\ue003</span><span class="ls6d ws211">modificaçõe s<span class="ff3 ws11f">\ue003</span><span class="ls177 ws212 v0">regul adoras <span class="ff3 ls118">\ue003</span><span class="ls180 ws167">conhe cidas <span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></span></span></span></div><div class="t m1 x2 h12 yf4 ff4 fs7 fc1 sc0 ls12d">\uf0b7<span class="ff5 ls137 wsc1"> </span><span class="ff6 ls11f ws127">Zimogênios<span class="ff3 ls6d">\ue003</span></span></div><div class="t m1 x7 h12 yf5 ffc fs7 fc1 sc0 ls12c">o<span class="ff5 ls144 wsc1"> </span><span class="ff6 ls1f1 ws213">Para<span class="ff3 ls118">\ue003</span><span class="ls15f ws184">algumas</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ws124">enzimas,</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls157 ws16a">um<span class="ff3 ls118">\ue003</span><span class="ls77 ws133">precursor</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls1f2 ws214">inat i vo, <span class="ff3 ls118">\ue003</span><span class="ls163 ws60">chamado<span class="_2 blank"> </span></span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls164 ws20f">zimogênio,<span class="ff3 ls118">\ue003</span><span class="ls130">é</span></span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls8a ws162">hidrolisado</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ls146 ws123">para</span><span class="ff3 ls6d ws11f">\ue003</span><span class="ff6 ws215">formar<span class="ff3 ls118">\ue003</span><span class="ls6d ws13b">a<span class="ff3">\ue003</span></span></span></div><div class="t m1 x2e h12 yf6 ff6 fs7 fc1 sc0 ls1db ws1e2">enzima<span class="ff3 ls6d ws11f">\ue003</span><span class="ls178 ws15f">ativa.<span class="ff3 ls6d ws11f">\ue003</span><span class="ls124 ws141">Podemos<span class="ff3 ls6d ws11f">\ue003</span><span class="ls122 ws140">encontra<span class="_1 blank"></span><span class="ff3 ls12d">\u2010<span class="ff6 ls1f3 ws216">las</span><span class="ls6d ws11f">\ue003<span class="ff6 ls157 ws122">no</span><span class="ls118">\ue003<span class="ff6 ls132 ws170">estomago</span>\ue003<span class="ff6 ls121">e</span></span>\ue003<span class="_1 blank"></span><span class="ff6 ls146 ws123">no<span class="ff3 ls6d ws11f">\ue003</span><span class="ls178 ws15f">pâncreas.<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m1 x1 h12 yf7 ff6 fs7 fc1 sc0 ls15f ws138">UHUW!!<span class="ff3 ls6d">\ue003</span></div><div class="t m6 x9 h22 yf8 ffa fse fc1 sc0 ls1aa wsc1">Comentad<span class="_1 blank"></span>o [Cacá <span class="_1 blank"></span>Fº9]: <span class="ff6 ls6d ws19c">A<span class="ff3 ws196">\ue003</span><span class="ls1a3 ws1a9">inibi<span class="_1 blank"></span>ção<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a1 ws1a7">irrever<span class="_1 blank"></span>sível<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">é</span>\ue003</span><span class="ls5b ws153">uma<span class="ff3 ls6d ws196">\ue003</span><span class="ls14d ws1aa">das<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m6 x9 h22 yf9 ff6 fse fc1 sc0 ls1c1 ws217">ferramentas<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f4 ws218">mais<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a3 ws1a9">importan<span class="_1 blank"></span>tes<span class="ff3 ls6d ws196">\ue003</span><span class="ls19b ws1a6">na<span class="ff3 ls152">\ue003</span><span class="ls1c2 ws219">pesquisa<span class="ff3 ls147">\ue003</span><span class="ls14d ws1aa">das<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f5 wsd8">enzimas<span class="ff3 ls6d ws196">\ue003</span><span class="ls6a ws1a5">em<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m6 x9 h22 yfa ff6 fse fc1 sc0 ls1f6 ws21a">farmacologia<span class="ff3 ls6d">\ue003</span></div><div class="t m6 x9 h22 yfb ffa fse fc1 sc0 ls1aa wsc1">Comentad<span class="_1 blank"></span>o [Cacá <span class="_1 blank"></span>Fº10]: <span class="_1 blank"></span><span class="ff6 ls1c3 ws21b">Esses<span class="ff3 ls6d ws196">\ue003</span><span class="ls199 ws197">inibidor<span class="_1 blank"></span>es<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">ocupam</span>\ue003</span><span class="ls14b ws199">um<span class="ff3 ls6d">\ue003</span></span></span></span></div><div class="t m6 x9 h22 yfc ff6 fse fc1 sc0 ls14d ws1aa">papel<span class="ff3 ls6d ws196">\ue003</span><span class="ls151 ws1b8">central<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">no<span class="ff3 ls6d ws196">\ue003</span><span class="ls1c4 ws21c">desenvolvimento<span class="ff3 ls147">\ue003</span><span class="lsd5 ws21d">racional<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f7 ws21e">de<span class="_1 blank"></span><span class="ff3 ls6d ws196">\ue003<span class="ff6 ls68 ws1a3">drogas,</span>\ue003<span class="ff6 ls5b ws153">uma</span>\ue003</span></span></span></span></span></span></div><div class="t m6 x9 h22 yfd ff6 fse fc1 sc0 ls14d ws1aa">abordagem<span class="ff3 ls6d ws196">\ue003</span><span class="lsd5 ws21d">moderna<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">para<span class="ff3 ls147">\ue003</span><span class="ls68">a<span class="ff3 ls6d ws196">\ue003</span><span class="ls5b ws153">obtenção<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">de<span class="ff3 ls147">\ue003</span><span class="ls19c ws11d">novos<span class="ff3 ls6d ws196">\ue003</span><span class="ls154 ws1c5">agentes<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m6 x9 h22 yfe ff6 fse fc1 sc0 ls1b5 ws1c8">farmacêuticos,<span class="ff3 ls6d ws196">\ue003</span><span class="ls1b0 ws21f">em<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">que<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">novos<span class="ff3 ls6d ws196">\ue003</span><span class="ls1c4 ws220">substratos<span class="ff3 ls6d ws196">\ue003</span></span></span></span></span>são<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f8 ws198">sintetizad os <span class="ff3 ls6d">\ue003</span></span></div><div class="t m6 x9 h22 yff ff6 fse fc1 sc0 ls1c5 ws221">baseando<span class="ff3 ls1c6">\u2010</span><span class="ls1a0 ws1a2">se<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">no<span class="ff3 ls6d ws196">\ue003</span><span class="ls154 ws1c5">conhecimento<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">dos<span class="ff3 ls6d ws196">\ue003</span><span class="ls1c7 ws222">substratos<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f9 ws223">já<span class="ff3 ls6d ws196">\ue003</span></span><span class="ws224">conhecidos<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></div><div class="t m6 x9 h22 y100 ff6 fse fc1 sc0 ls1c8">e<span class="ff3 ls6d ws196">\ue003</span><span class="lsd3 ws1b3">nos</span><span class="ff3 ls6d ws196">\ue003</span><span class="ls1fa ws225">mecan<span class="_2 blank"> </span>ismos</span><span class="ff3 ls6d ws196">\ue003</span><span class="ls14d ws1aa">das<span class="_2 blank"> </span></span><span class="ff3 ls6d ws196">\ue003</span><span class="ls151 ws1b8">reações.<span class="ff3 ls6d">\ue003</span></span></div><div class="t m6 x9 h22 y101 ffa fse fc1 sc0 ls1aa wsc1">Comentad<span class="_1 blank"></span>o [Cacá <span class="_1 blank"></span>Fº11]: <span class="_1 blank"></span><span class="ff6 ls1fb ws226">Um<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a3 ws1a9">inibidor<span class="ff3 ls6d ws196">\ue003</span><span class="ls155 ws1c9">suicida<span class="ff3 ls6d ws196">\ue003</span><span class="ls19b ws1a6">bem<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="t m6 x9 h22 y102 ff6 fse fc1 sc0 ls150 ws1b2">planejado<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">é</span>\ue003</span><span class="ls151 ws1b8">especifico<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f7 ws21e">para<span class="ff3 ls6d ws196">\ue003</span><span class="ls19b ws1a6">uma<span class="ff3 ls6d ws196">\ue003</span><span class="ls149 ws19d">única<span class="ff3 ls6d ws196">\ue003</span><span class="ls68 ws227">enzima<span class="ff3 ls6d ws196">\ue003<span class="ff6 ws19c">e</span>\ue003</span><span class="ls14d ws1aa">não<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">reativo<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></span></span></div><div class="t m6 x9 h22 y103 ff6 fse fc1 sc0 ls68 ws228">até<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">que<span class="ff3 ls6d ws196">\ue003</span><span class="ls1fc ws229">esteja<span class="ff3 ls6d ws196">\ue003</span><span class="ls19b ws22a">dentro <span class="ff3 ls6d ws196">\ue003</span></span></span>do<span class="ff3 ls6d ws196">\ue003</span><span class="ls14e ws1ae">sítio<span class="ff3 ls6d ws196">\ue003</span><span class="ls1af ws1c0">ativo<span class="ff3 ls6d ws196">\ue003</span></span></span>da<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f5 wsd8">enzima.<span class="ff3 ls6d ws196">\ue003</span><span class="ls1fd ws1cb">Ass i m, <span class="ff3 ls6d ws196">\ue003</span></span></span></span><span class="ws1a3">as<span class="ff3 ls6d">\ue003</span></span></div><div class="t m6 x9 h22 y104 ff6 fse fc1 sc0 ls1af ws1c0">drogas<span class="ff3 ls6d ws196">\ue003</span><span class="ls1c9 ws22b">baseadas<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a0 ws1a2">nessa<span class="ff3 ls6d ws196">\ue003</span><span class="ls1c4 ws21c">estratégia<span class="ff3 ls6d ws196">\ue003</span><span class="ls1f5 ws22c">oferecem<span class="ff3 ls6d ws196">\ue003</span><span class="lsd0 ws1bb">grande<span class="ff3 ls6d">\ue003</span></span></span></span></span></span></div><div class="t m6 x9 h22 y105 ff6 fse fc1 sc0 ls1fe ws22d">vanta<span class="_1 blank"></span>gem<span class="ff3 ls6d ws196">\ue003</span><span class="ls14b ws199">de<span class="ff3 ls6d ws196">\ue003</span>apresentar<span class="ff3 ls6d ws196">\ue003</span><span class="ls1af ws1c0">poucos<span class="ff3 ls6d ws196">\ue003</span><span class="ls1a6 ws1ad">ef<span class="_1 blank"></span>eito<span class="_1 blank"></span>s<span class="ff3 ls6d ws196">\ue003</span><span class="ls1cf ws22e">colaterais.<span class="ff3 ls6d">\ue003</span></span></span></span></span></div><div class="c x9 y106 wa h25"><div class="t m6 x10 h26 y107 ffa fse fc1 sc0 ls1a1">Co</div></div><div class="t m6 x2f h26 y108 ffa fse fc1 sc0 ls6d">m</div><div class="c x9 y106 wa h25"><div class="t m6 x30 h26 y107 ffa fse fc1 sc0 ls6d">e</div></div><div class="t m6 x31 h26 y108 ffa fse fc1 sc0 ls6d">n</div><div class="c x9 y106 wa h25"><div class="t m6 x32 h26 y107 ffa fse fc1 sc0 ls1ff ws22f">tado</div></div><div class="t m6 x33 h26 y108 ffa fse fc1 sc0 ls6d wsc1"> </div><div class="c x9 y106 wa h25"><div class="t m6 x34 h26 y107 ffa fse fc1 sc0 ls200 ws230">[Cacá</div></div><div class="t m6 x35 h26 y108 ffa fse fc1 sc0 ls200 wsc1"> Fº12</div><div class="c x9 y106 wa h25"><div class="t m6 x36 h26 y107 ffa fse fc1 sc0 ls1fb">]:</div></div><div class="t m6 x37 h26 y108 ffa fse fc1 sc0 ls1ca wsc1"> <span class="ff3 ls6d">\ue003</span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div>
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