Buscar

Formulary for Primates

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Você viu 3, do total de 15 páginas

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Você viu 6, do total de 15 páginas

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Você viu 9, do total de 15 páginas

Faça como milhares de estudantes: teste grátis o Passei Direto

Esse e outros conteúdos desbloqueados

16 milhões de materiais de várias disciplinas

Impressão de materiais

Agora você pode testar o

Passei Direto grátis

Prévia do material em texto

FORMULARY
Association of 
Primate Veterinarians
APV Primate Formulary
Compiled By
D. Rick Lee, DVM and CJ Doane, DVM
Alamogordo Primate Facility
Thanks to the generous support of the 
Griffin Foundation
DISCLAIMER: The drug doses listed in this formulary were taken from several
references and the authors' personal experience. As always, exercise professional
judgement when selecting a dose. While every effort has been made to ensure the
accuracy of information contained herein, the publisher, editor and contributors are not
legally responsible for errors or omissions.
TABLE OF CONTENTS
FORMULARY
 Antibiotics
 Analgesics / Anti-Inflammatories
 Anesthesics / Sedatives
 Antiparasitic
 Antifungal
 Cardiovascular
 Vitamins / Supplements
 Miscellaneous
 Emergency 
NORMAL VALUES
 Chimpanzees
NEW WORLD NORMAL VALUES
 Bolivian Squirrel Monkey
 Owl Monkey
OLD WORLD NORMAL VALUES
 Baboon
 Rhesus
 Cynomologus
References
National B Virus Resource Center
ANTIBIOTICS ANTIBIOTICS
Drug Monkey Drug Chimpanzee Adult / Human*
Amikacin 5mg/kg IM TID Amikacin 2.3mg/kg IM SID
Amoxicillin 6.7-13.3mg/kg IM/PO TID Amoxicillin 500 mg IV/IM/PO TID
Amoxicillin/Clavulonic Acid 6.7-13.3mg/kg PO TID Amoxicillin/Clavulonic Acid 13.75mg/kg PO BID
Ampicillin 25-50mg/kg/day IV/IM div TID-QID; 
meningitis/septicemia 150-200mg/kg/day div 
q3-4hrs
Ampicillin 20mg/kg IV/IM/PO TID
Azithromycin 40mg/kg PO SID 1st day; then 20mg/kg PO 
SID 2-5th days
Azithromycin 5-10mg/kg PO SID
Cefataxime 50mg/kg IM TID Cefataxime 1gr IV/IM BID/TID/QID
Cefazolin 20mg/kg IV/IM TID Cefazolin 25mg/kg IV/IM BID
Ceftiofur 2.2mg/kg IM SID Ceftiofur 2mg/kg IM SID
Ceftriaxone 50mg/kg IM SID Ceftriaxone 50-100mg/kg IM SID-BID
Cephalexin 30mg/kg PO BID Cephalexin 1-4 grams ÷BID-TID
Chloramphenicol Palmitate 25mg/kg PO TID Infants Chloramphenicol Palmitate
Chloramphenicol Succinate 33.3mg/kg IM TID Adults Chloramphenicol Succinate 20mg/kg IM BID, 50mg/kg SQ TID
Ciprofloxacin 10mg/kg PO BID Ciprofloxacin 16-20mg/kg PO BID
Clarithromycin Clarithromycin 250-500mg PO BID x7-14d
Clindamycin 12.5mg/kg IM TID Clindamycin 150-300mg PO QID; 300-600mg IM BID/TID
Doxycycline 2.5mg/kg PO BID 1st day; 2.5mg/kg PO SID 
day 2
Doxycycline 2-5mg/kg PO BID
Enrofloxacin 5mg/kg IM/PO SID/BID Enrofloxacin 5mg/kg IM, PO SID
Erythromycin 35mg/kg PO TID; 15-20mg/kg/day IM BID Erythromycin 500mg PO BID before meal*
Furazolidone 10mg/kg PO BID Furazolidone 100mg PO QID
Gentamicin 2-4mg/kg IM BID Gentamicin 2-4mg/kg IV/IM BID
Levoquin Levoquin 500mg PO SID
Metronidazole 50mg/kg PO SID Metronidazole 25mg/kg PO BID
Minocycline 4mg/kg PO Minocycline 200mg, then 100mg IV(slow)/PO BID
Neomycin 50mg/kg PO BID Neomycin
Ofloxacin Ofloxacin 200-400mg IV CRI/PO
Oxacillin 16.7mg/kg IM TID Oxacillin
Oxytetracycline 25-50mg/kg PO; 10mg/kg IM/SQ Oxytetracycline 250-300mg/day IM/PO div SID-TID
Penicillin G Benzathine 20,000-60,000 IU/kg IM SID Penicillin G Benzathine 1,200,000 units deep IM once*
Penicillin G Potassium 6,700-13,300 IU/kg IV/IM TID Penicillin G Potassium 1-20 million units per day IV/IM*
Penicillin G Procaine 20,000-40,000 IU/kg IM/SQ BID Penicillin G Procaine 22,000 IU/kg IM SID
Penicillin V Potassium Penicillin V Potassium 11mg/kg PO QID
Rifampin Rifampin 600mg IV/PO SID
Rifampin/Isoniazid Rifampin/Isoniazid 600mg rifampin/ 300mg isoniazid PO SID
Streptomycin 2.5-5mg/kg IM BID Streptomycin 1-2g/d divided in 6-12 hour intervals
Sulfadimethoxine 50mg/kg 1st day, then 25mg/kg IM SID Sulfadimethoxine
Sulfamethoxazole/Trimethopr
im
trimethoprim: 4mg/kg SQ/PO TID Sulfamethoxazole/Trimethopr
im
Sulfa: 800mg PO BID; 15-20mg/kg/day IV div 
BID-QID
Tetracycline 20mg/kg PO TID Tetracycline 20-25mg/kg PO TID-BID
Ticarcillin/Clavulanate 
Potassium 
ticarcillin: 65-100mg/kg IV TID Ticarcillin/Clavulanate 
Potassium 
200-300mg/kg/d divided evenly and given q4-
6hrs
Tylosin 2mg/kg IM SID Tylosin
Vancomycin 20mg/kg IV/IM BID Vancomycin 500mg PO QID x7-10d; can give IV slow
ANALGESICS / ANTI-INFLAMMATORIES ANALGESICS / ANTI-INFLAMMATORIES
Drug Monkey Drug Chimpanzee Adult / Human*
Acetominophen 6mg/kg PO TID Acetominophen 500-1000mg PO TID
Acetominophen/Codeine Acetominophen/Codeine .24-36mg (10-15ml) q 6hr
Acetylsalicylic Acid 20mg/kg PO BID/TID Acetylsalicylic Acid 5-10mg/kg PO QID
Buprenorphine .01-.03mg/kg IM BID Buprenorphine NTE .3mg IM TID
Butorphanol .05mg/kg IM TID; New World: 0.02mg/kg 
SQ QID
Butorphanol
Carprofen 2mg/kg PO BID Carprofen 2mg/kg PO BID
Celecoxib Celecoxib 200mg PO SID/BID 
Deracoxib Deracoxib acute: 4mg/kg PO SID; chronic: 2mg/kg PO 
SID
Dexamethasone Shock: 2-4mg/kg IV once CNS: .25-2mg/kg 
IM BID; Anti-inflam: .25-1mg/kg IM SID; CNS: 
.25-2mg/kg IM BID
Dexamethasone 2mg/kg IV/IM/PO
Fentanyl 7-10mcg/kg/hr IV CRI; .05-.15mcg/kg IM PRN; 
Patch: 25mcg/5-10kg, 50mcg/10kg animal q48-
72h
Fentanyl 5-10mcg/kg/hr IV CRI
Flunixin Meglimine 2mg/kg IM BID Flunixin Meglimine
Hydrocodone Bitartrate Hydrocodone Bitartrate 5mg PO q4-6hr PRN
Hydrocortisone Sodium 
Succinate
Hydrocortisone Sodium 
Succinate
5mg/kg IV/IM BID
Ibuprofen 7mg/kg PO BID Ibuprofen 200-400mg PO TID
Ketoprofen 2mg/kg IV/IM SID Ketoprofen 2mg/kg IV/IM SID
Ketorolac 15-30mg/animal initially; then 10-15mg/animal 
q8h
Ketorolac 30mg PO QID or one dose of 60mg*
Lidocaine .7-1.4mg/kg IV PRN Lidocaine 1-1.5mg/kg IV, max of 3mg/kg
Meperidine HCl 2-4mg/kg IM/IV q1/2-1h Meperidine HCl 50-150mg PO q3-4hrs or PRN
Morphine Sulfate 1-2mg/kg IV/IM/SQ q4h Morphine Sulfate 0.01-0.1mg/kg IV*
Nalbuphine 2.5-5mg/kg IM q3-4h Nalbuphine 10mg IV/IM/SQ q3-6hr PRN*
Naloxone .1mg/kg IV/IM/SQ PRN Naloxone 15mcg/kg IV/IM/SQ PRN 
Naltrexone Naltrexone 3mg/kg SID
Naproxen Naproxen 5mg/kg PO SID
Oxymorphone .15mg/kg IV/IM/SQ q4-6h; 
New World: .025mg/kg IV/IM/SQ q4-6h
Oxymorphone 1-1.5mg IM/SQ q4-6hr PRN*
Prednisolone Sodium 
Succinate
10mg/kg IM/IV Prednisolone Sodium 
Succinate
10mg/kg IV
Prednisone/Prednisolone .5-2mg/kg PO Prednisone/Prednisolone .5-2.2mg/kg PO
Triamcinalone .02-2mg/kg IM PRN Triamcinalone
ANESTHETICS / SEDATIVES ANESTHETICS / SEDATIVES
Drug Monkey Drug Chimpanzee Adult / Human*
Acepromazine 0.1-.5mg/kg IV/IM Acepromazine .5-1.0mg/kg IM/SQ/PO
Atipamezole .15mg/kg IV/IM Atipamezole 150-300ug/kg IV/IM
Diazepam seizure: .5-1mg/kg IV/IM Diazepam .25-.5mg/kg IV/IM; .5-1mg/kg PO
Droperidol Droperidol 2.5-10mg IM 30-60min before procedure
Fentanyl/Droperidol 0.1-0.3ml/kg IM; New World: 0.05ml/kg IM Fentanyl/Droperidol 0.3ml/kg IM
Haloperidol .03-.05mg/kg IM BID Haloperidol 0.5-5.0mg PO BID/TID*
Ketamine 10mg/kg IM; 5mg/kg IV; 
New World: 10-15mg/kg IM
Ketamine 5-40mg/kg IM
Ketamine/Xylazine Ket 7mg/kg IM; Xyl 0.6mg/kg IM New 
World: Ket 10-20mg/kg IM; Xyl 3.0mg/kg IM
Ketamine/Xylazine Ket 15-20mg/kg IM; Xyl 1.0mg/kg IM
Meditomidine 10-35mcg/kg IM Meditomidine 30-60ug/kg IM preceded by Ketamine 2-
6mg/kg IM
Midazolam .05-.1mg/kg IV(slow)/IM Midazolam 1-2.5mg IV; 5mg IM*
Pentobarbital adult: 25mg/kg IV slowly to effect; juvenile 
15mg/kg IV slowly to effect; 
New World: 15mg/kg IV slowly to effect
Pentobarbital 100mg initial dose IV not to exceed 50mg/min; 
150-200mg IM*
Phenobarbital Seizure: 2mg/kg IV; 1-6mg/kg PO Phenobarbital
Propofol 2.5-5mg/kg bolus then 0.3-0.4mg/kg/min CRI Propofol 1-2mg/kg bolus followed by CRI to effect
Thiamylal Sodium 15-25mg/kg IV to effect Thiamylal Sodium
Thiopental 25mg/kg IV to effect Thiopental
Tiletamine/Zolazepam 5-8mg/kg IM; NewWorld: 1-2.5mg/kg IM Tiletamine/Zolazepam 3-5mg/kg IM; 20-80mg IV supplement
Xylazine .5-6mg/kg IM Xylazine 1.1mg/kg IV; 2.2mg/kg IM
Yohimbine .1mg/kg IV/IM Yohimbine 0.11mg/kg IV/IM
ANTIPARASITICS ANTIPARASITICS
Drug Monkey Drug Chimpanzee Adult / Human*
Chloroquine Phosphate 10mg/kg NGT day 1 AM; 5mg/kg NGT day 1 
PM, day 2 + 3 SID
Chloroquine Phosphate Suppression: 500mg PO q7d*
Fenbendazole 50mg/kg/day PO x3 days, repeat in 3 weeks, 
repeat in 3 months
Fenbendazole 50mg/kg/day PO x3d, repeat in 3 weeks
Iodoquinol 12mg/kg PO TID x10-20days Iodoquinol 630mg PO TID x20days
Ivermectin .2mg/kg SQ/PO Ivermectin .2mg/kg SQ/PO
Mebendazole 50mg/kg PO BID x3d; Trichuris: 100mg/kg PO 
BID x3d, repeat in 3wks
Mebendazole 100mg PO BID x3days
Mefloquine 25mg/kg NGT one dose Mefloquine active: 1250mg PO once; preventative: 250mg 
PO q7d
Praziquantel 5mg/kg IM/SQ/PO one dose Praziquantel 20mg/kg PO TID x1d
Primiquine .3mg/kg NGT SID x14d Primiquine
Pyrantel Pamoate Pyrantel Pamoate 10mg/kg PO, repeat in 3 wks
Thiabendazole adult: 100mg/kg PO SID, infant 50mg/kg PO 
SID x2d
Thiabendazole 7500-1500mg PO SID x2d (x7d for visceral 
larva migrans)
Yomesin 37.5mg PO SID x5d Yomesin
ANTIFUNGALS ANTIFUNGALS
Drug Monkey Drug Chimpanzee Adult / Human*
Flucytosine Flucytosine 50-150mg/kg/day PO div QID
Griseofulvin 20mg/kg PO SID; or 200mg/kg PO q10d Griseofulvin 500mg/day PO div SID-QID
Ketoconazole 5-10mg/kg PO BID Ketoconazole 200-400mg/day PO
Nystatin 100,000 units PO TID Nystatin 500K-1 million units PO TID
CARDIOVASCULAR CARDIOVASCULAR
Drug Monkey Drug Chimpanzee Adult / Human*
Amlodipine Amlodipine .1mg/kg PO SID
Carvedilol Carvedilol 3.125mg PO BID x2wk then inc to 6.25mg PO 
BID; inc PRN
Digoxin maint: 2-12mcg/kg IV/IM div SID-BID; 
2-15mcg/kg PO div SID-BID
Digoxin .005-.01mg/kg PO BID; .005-.01mg/kg IV PRN
Diltiazam HCl Diltiazam HCl .25-.35mg/kg IV slow, 180-240mg PO SID
Dobutamine HCl 2.5-10mcg/kg/min IV CRI Dobutamine HCl 2.5-10mcg/kg/min IV CRI
Dopamine HCl 2-5mcg/kg/min IV CRI - renal; 5-15mcg/kg/min 
IV CRI - cardio
Dopamine HCl 2-5mcg/kg/min IV CRI
Enalapril Enalapril .3mg/kg IV/PO
Hydralazine HCl Hydralazine HCl
Lisinopril Lisinopril .25-.5mg/kg PO SID
Nitroglycerin Nitroglycerin 7.5mg topically TID
Norepinephrine Norepinephrine .2-4mcg/min IV CRI
Procainamide Procainamide 50mg/kg/day PO div QID
Propranolol Propranolol .25-1mg/kg PO TID-BID
Quinidine Sulfate Quinidine Sulfate 100-200mg PO BID-TID
Sodium Nitroprusside Sodium Nitroprusside .3-10mcg/kg/min IV CRI
VITAMINS / SUPPLEMENTS VITAMINS / SUPPLEMENTS
Drug Monkey Drug Chimpanzee Adult / Human*
Calcitriol Calcitriol .03mg/kg PO SID
Ferrous Sulfate Ferrous Sulfate 325mg PO SID 
Folic Acid 15mcg/kg PO SID Folic Acid 500ug/day PO*
Iron Dextran 10mg/kg IM q7d Iron Dextran 11-22mg/kg IM
Vitamin B12 Vitamin B12 3-5ml IV/IM/PO
Vitamin C 30mg/kg IM SID Vitamin C 4-25mg/kg PO SID 
Vitamin D3 Vitamin D3 20 IU/kg PO SID
Vitamin E Vitamin E 3.75 IU/kg PO SID
Vitamin K1 1-5mg/day IM Vitamin K1 1mg/kg IM/PO TID
Zinc 2.5mcg/day x3d Zinc 1 75mg tablet BID PRN
MISCELLANEOUS MISCELLANEOUS
Drug Monkey Drug Chimpanzee Adult / Human*
Adequan 2mg/kg IM q3-5d x 2-3mo Adequan 2-3mg/kg q4d x2mo
Allopurinol Allopurinol 200-600mg/day
Aluminum Hydroxide Aluminum Hydroxide 600-1200mg PRN
Aminophylline 25-100mg/animal PO SID Aminophylline 10mg/kg IV
Atropine Sulfate .02-.04mg/kg IV/IM/SQ Atropine Sulfate .02-.05mg/kg IV/IM/SQ
Azathioprine 1-2mg/kg PO SID Azathioprine 1-2.5mg/kg/day PO*
Bisacodyl Bisacodyl 10-15mg PO PRN
Bismuth Subsalicylate 40mg/kg PO BID/TID Bismuth Subsalicylate 30mls PO PRN
Calcium Gluconate Calcium Gluconate 200mg/kg IV/IM/SQ
Cholestyramine Resin Cholestyramine Resin 8-16g/d PO BID
Chorionic Gonadotropin Chorionic Gonadotropin 5,000-10,000 USP units IM
Cimetidine 10mg/kg IM/PO TID Cimetidine 300mg IV(slow)/IM/PO TID/QID
Dapsone Dapsone 50mg/day PO, leprosy: 100mg/day PO
Denosyl SD4 (SAM-e) Denosyl SD4 (SAM-e) 18mg/kg PO SID
Diphenhydramine HCl 5mg/kg/day TID/QID IV/IM/PO Diphenhydramine HCl 25-50mg TID/QID IV/IM/PO
Docusate Sodium (DSS) 10-40mg PO Docusate Sodium (DSS) 50-200mg PO
Doxapram infant: 2mg/dose, adult: 2mg/kg max Doxapram 2mg/kg IV 
Epinephrine .1-.5mg IV/IC/IM/SQ Epinephrine .2-1mg IM/SQ; .5-10mg IV/ IC
Epoetin 50-100units/kg IV/SQ 3x/wk Epoetin 50-100units/kg IV/SQ 3x/wk
Ethambutol Ethambutol start 15mg/kg /day PO, then 25mg/kg/day PO
Fluoxetine Fluoxetine .5-1mg/kg PO SID
Furosemide 2-4mg/kg IM TID; 1-4mg/kg IV Furosemide 1-2mg/kg IV/IM/PO
Glycopyrrolate .004-.008mg/kg IM Glycopyrrolate .004mg/kg IV/IM; 1mg PO TID
Guaifenesin Guaifenesin 10-20mls PO q4-6h
Heparin Heparin 5-10K units IV QID; 10-20K units SQ BID
Hydrochlorothiazide Hydrochlorothiazide 1mg/kg PO SID
Insulin NPH Insulin NPH .25-.5units/kg/day SQ
Isoniazid 5mg/kg PO SID Isoniazid Active TB: 30-50mg/kg PO SID x9mos; 
Prophy: 300mg/day PO 
Isoproterenol .05-2mcg/kg/min IV CRI Isoproterenol .1-1mcg/kg/min IV CRI; .02-.06mg IV bolus
Leuprolide .3mg/kg IM q4wks Leuprolide
Loperamide .04mg/kg PO TID Loperamide 4mg PO PRN
Mannitol Cerebral edema: 1.65-2.2g/kg IV over 20 min; 
Diuretic: .25-.5g/kg IV over 5-10 min
Mannitol .5-1.0g/kg IV
Medroxyprogesterone 
acetate
150mg IM q3mos; 5-10mg PO SID x5-10d Medroxyprogesterone 
acetate
150mg IM q3mos
Megesterol Acetate Megesterol Acetate 800mg PO SID
Metformin Hydrochloride Metformin Hydrochloride 1500-2250mg/day PO, titrate to effect*
Metoclopramide .2-.5mg/kg IM SID-TID Metoclopramide .4mg/kg IV(slow)/IM/PO SID-TID
Misoprostol Misoprostol 5mcg/kg PO QID; 1-3mcg/kg intravaginally
Neostigmine .07-.08mg/kg IM q2-4h Neostigmine 0.5mg IM/SQ*
Oxytocin 2units/dose PRN Oxytocin .5-1mU/min IV CRI; 5-30 units IV/SQ PRN
Pancuronium .04-.1mg/kg IV PRN Pancuronium
Paromomycin 25-30mg/kg/day PO div BID Paromomycin
PGF2alpha 1mg/kg IM SID PGF2alpha
Phentolamine Mesylate Phentolamine Mesylate 5-10mg IV/SQ
Phenytoin 2.5mg/kg PO BID, increase PRN Phenytoin 125mg PO TID adjust PRN*
Potassium Chloride 20-100mEq PO SID; .5-1mEq/kg/hr IV Potassium Chloride 20-100mEq PO SID; .5-1mEq/kg/hr IV
Probenicid Probenicid 1gm PO BID x7days
Prochlorperazine .12mg/kg IV/IM Prochlorperazine 5-10mg IV/IM/PO SID-TID
Ranitidine .5mg/kg PO BID Ranitidine 150mg PO BID/TID*
Spironolactone Spironolactone 20-300mg/day div SID-TID
Stanozolol 5-10mg/kg IM q4-7d Stanozolol 2mg PO TID-QID
Succinylcholine 1mg/kg IV PRN Succinylcholine 0.3-1.1mg/kg IV for 2 min; 2.5-4.3mg/min CRI*
Sucralfate .5gm/dose; maintenance BID, active ulcer 4-
6wks QID
Sucralfate 1gm PO BID 
Sulfasalzine 10mg/kg PO TID Sulfasalzine 3-4g/day PO*
Terbutaline Terbutaline 5mg PO SID
Testosterone Testosterone 10-25mg IM 2-3x/wk
Theophylline Theophylline 5mg/kg, then 2-4mg/kg TID-QID
Winstrol Winstrol 2-4mg PO SID
EMERGENCY EMERGENCY
Drug Monkey Drug Chimpanzee Adult / Human* 
Aminophylline Aminophylline 10mg/kg IV
Atropine Sulfate .02-.04mg/kg IV/IM/SQ Atropine Sulfate .02-.05mg/kg IV/IM/SQ
Dexamethasone Shock: 2-4mg/kg IV once CNS: .25-2mg/kg 
IM BID; Anti-inflam: .25-1mg/kg IM SID; CNS: 
.25-2mg/kg IM BID
Dexamethasone 2mg/kg IV/IM/PO
Diazepam seizure: .5-1mg/kg IV/IM Diazepam .25-.5mg/kg IV/IM; .5-1mg/kg PO
Diphenhydramine HCl 5mg/kg/day TID/QID IV/IM/PO Diphenhydramine HCl 25-50mg TID/QID IV/IM/PO
Dobutamine HCl 2.5-10mcg/kg/min IV CRI Dobutamine HCl 2.5-10mcg/kg/min IV CRI
Dopamine HCl 2-5mcg/kg/min IV CRI - renal; 5-15mcg/kg/min 
IV CRI - cardio
Dopamine HCl 2-5mcg/kg/min IV CRI
Doxapram infant: 2mg/dose, adult: 2mg/kg max Doxapram 2mg/kg IV 
Epinephrine .1-.5mg IV/IC/IM/SQ Epinephrine .2-1mg IM/SQ; .5-10mg IV/ IC
Furosemide 2-4mg/kg IM TID; 1-4mg/kgIV Furosemide 1-2mg/kg IV/IM/PO
Glycopyrrolate .004-.008mg/kg IM Glycopyrrolate .004mg/kg IV/IM; 1mg PO TID
Insulin NPH Insulin NPH .25-.5units/kg/day SQ
Isoproterenol .05-2mcg/kg/min IV CRI Isoproterenol .1-1mcg/kg/min IV CRI; .02-.06mg IV bolus
Lidocaine .7-1.4mg/kg IV PRN Lidocaine 1-1.5mg/kg IV, max of 3mg/kg
Mannitol Cerebral edema: 1.65-2.2g/kg IV over 20 min; 
Diuretic: .25-.5g/kg IV over 5-10 min
Mannitol .5-1.0g/kg IV
Naloxone .1mg/kg IV/IM/SQ PRN Naloxone 15mcg/kg IV/IM/SQ PRN 
Naltrexone Naltrexone 3mg/kg SID
Nitroglycerin Nitroglycerin 7.5mg topically TID
Norepinephrine Norepinephrine .2-4mcg/min IV CRI
Pentobarbital adult: 25mg/kg IV slowly to effect; juvenile 
15mg/kg IV slowly to effect; 
New World: 15mg/kg IV slowly to effect
Pentobarbital 100mg initial dose IV not to exceed 50mg/min; 
150-200mg IM*
Prednisolone Sodium 
Succinate
10mg/kg IM/IV Prednisolone Sodium 
Succinate
10mg/kg IV
Procainamide Procainamide 50mg/kg/day PO div QID
Propranolol Propranolol .25-1mg/kg PO TID-BID
Terbutaline Terbutaline 5mg PO SID
Theophylline Theophylline 5mg/kg, then 2-4mg/kg TID-QID
NORMAL VALUES
CHIMPANZEE
Hematology
Value
Infant 
(<1yr)
Juvenile 
(1-3yrs)
Adolescent 
(3-6yrs)
Young Adult 
(6-10yrs)
Adult 
(10-20yrs)
Adult 
(>20yrs)
RBC x10
6
/μl 4.7-5.8 4.6-5.4 4.6-5.8 4.7-6.1
Hgb (gm/dl) 11.5-14.7 11.9-15.2 12.8-16.4 12.2-16.8
Hct (%) 35-44 36-44 37-48 37-50
MCV (fl) 68-81 75-84 76-85 76-88
MCH (pg) 22-27 25-28 25-29 25-30
MCHC (gm/dl) 32-34 32-34.4 32.5-34.6 32.1-34.1
WBC x10
3
/μl 6.64-16.0 6.93-16.3 6.4-16.2 7.74-17.02 7.2-14.8 6.48-16.25
Mono x10
3
/μl 0-0.6 .29-3.32 .17-3.22 .2-3.39 .41-3.61 .51-3.32
Lymph x10
3
/μl 26.27-68.63 25.14-56.67 22.73-59.71 23.4-60.56 25.09-58.81 22.16-60.27
Neut x10
3
/μl 2.34-8.83 1.87-10.4 2.15-10.88 2.7-11.26 2.6-10.98 1.83-11.07
Eosin x10
3
/μl .01-.21 0-.39 .01-.4 0-.41 0-.45 0-.4
Platelets x10
3
/μl 192-530 236-429 148-363 137-347
NORMAL VALUES
CHIMPANZEE
Serum Chemistry
Value
Infant 
(<1yr)
Juvenile 
(1-3yrs)
Adolescent 
(3-6yrs)
Young Adult 
(6-10yrs)
Adult 
(10-20yrs)
Adult 
(>20yrs)
Tot bili (mg/dl) .1-.6 0-.7 .04-.76 .21-.58
ALT (U/L) 23-52 23-52 18-46 17-38 20-44 23-48
AST (U/L) 13-34 14-32 11-31 13-46 13-46 12-29
Alk Phos (U/L) 396-914 357-704 145-789 9-185 54-153 212-582
Creatinine (mg/dl) .5-.9 .5-.8 .6-1.7 .7-1.2 .8-1.3 .5-1.0
Glucose (mg/dl) 68-125 65-120 65-110 60-100 66-108 56-119
BUN (mg/dl) 7-20 10-20 9-23 7-17 9-17 7-19
Tot protein (gm/dl) 6.0-7.6 6.4-7.8 6.8-8.0 7.0-8.2 6.7-8.3 6.4-7.7
Albumin (gm/dl) 3.2-4.2 3.4-4.2 3.5-4.4 3.0-4.0 3.3-4.1 3.4-4.1
Globulin (gm/dl) 2.4-3.7 2.7-4.1 3.7-4.1 3.5-4.7 3.2-4.7 2.6-4.0
Cholesterol (mg/dl) 178-357 190-285 162-298 182-265 170-288 190-300
GGT (U/L) 9-114 1-20 13-24 10-35
Triglycerides (mg/dl) 32-135 49-124 40-108 44-154 56-164 41-104
Ca (mg/dl) 9.6-11.9 8.7-11.7 8.8-9.4 7.6-10.9 8.1-10.2 9.2-11.1
Phos (mg/dl) 4.7-7.7 1.6-6.1 1.9-5.3 1.8-4.3
CPK (U/L) 32-386 98-309 78-366 80-553
LDH (U/L) 216-553 230-435 125-408 194-435 203-503 265-480
Cl (mEq/L) 100-115 104-120 93-119 93-115
Na (mEq/L) 130-146 129-146 95-147 136-148
K (mEq/L) 2.9-6.0 3.6-4.7 3.6-4.5 2.8-4.4 3.2-4.4 3.2-4.9
HDL (mg/dl) 44-114 43-103 32-92 35-82
LDL (mg/dl) 98-242 119-195 109-174 106-209
From Lab Animal Medicine ed 2
NEW WORLD NORMAL VALUES
Hematology Serum Chemistry Urinalysis (Dipstick)
Value Value Value
RBC x10
6
/μl 4.4-6.9 Tot bili (mg/dl) 0.3-1.2 Urine Specific Gravity 1.002-1.023
Hgb (gm/dl) 11.7-18.4 ALT (U/L) 10-93 Vol (ml/kg/d) 74.4-89.4
Hct (%) 36.6-52.2 Alk Phos (U/L) 0-1951 Protein 0-3+
MCV (fl) 76.3-86.3 Creatinine (mg/dl) 0.6-1.5 Glucose 0-1+
MCH (pg) 24.6-28.4 Glucose (mg/dl) 103-212 Ketones 0-2+
MCHC (gm/dl) 31.4-33.9 BUN (mg/dl) 6-28 Bilirubin 0
WBC x10
3
/μl 3.0-25.4 Tot protein (gm/dl) 7.0-9.2 Urobilinogen 0
Monos x10
3
/μl 0-0.6 Albumin (gm/dl) 3.2-5.0 Occult blood 0-4+
Lymph x10
3
/μl 3.5-10.6 Cholesterol (mg/dl) 65-196 pH 6-8.5
Neut x10
3
/μl 1.0-6.5 GGT (U/L) 3-47
Eos x10
3
/μl 0-2.9 Ca (mg/dl) 8.3-11.4
Baso x10
3
/μl 0-0.4 Phos (mg/dl) 2.5-6.3
Platelets x10
6
/μl 205-550 Na (mEq/L) 145-165
K (mEq/L) 2.6-6.8
From Lab Animal Medicine ed 2
OWL MONKEY
OLD WORLD NORMAL VALUES
BABOON
Hematology Serum Chemistry
Value Individual Caged Gang-caged Corralled Value Male Female
RBC x10
6
/μl 4.27-5.69 4.07-5.79 3.76-5.61 Tot bili (mg/dl) 0.0-0.4 0.1-0.3
Hgb (gm/dl) 10.6-14.4 10.3-14.9 9.5-14.5 Direct bili (mg/dl) 0.0-0.2 0.0-0.2
Hct (%) 32.4-43.5 32.5-44.9 29.0-45.2 ALT (U/L) 29-69 4-84
MCV (fl) 70.8-83.4 72.3-85.5 70.6-84.4 AST (U/L) 29-69 18-50
MCH (pg) 23.4-27.2 23.5-28.3 22.6-28.3 Alk Phos (U/L) 0-555 0-560
MCHC (gm/dl) 31.6-34.6 30.9-33.9 30.8-34.4 Creatinine (mg/dl) 0.7-1.5 0.5-1.1
WBC x10
3
/μl 3.1-15.5 3.2-17.0 1.8-27.4 Glucose (mg/dl) 65-101 40-136
Mono% 0-5 0-5 0-7 BUN (mg/dl) 9-19 7-20
Lymph % 6-66 10-88 0-49 Tot protein (gm/dl) 6.3-7.9 5.9-8.1
Neut % 32-90 9-87 47-100 Albumin (gm/dl) 2.3-5.1 1.8-4.6
Eosin % 0-3 0-4 0-2 Globulin (gm/dl) 2.3-4.7 2.8-4.6
Baso % 0 0-1 0-1 Cholesterol (mg/dl) 52-150 27-167
Platelets x10
6
/μl 164-521 150-550 104-566 GGT (U/L) 23-63 11-53
Triglycerides (mg/dl) 36-94 32-104
Ca (mg/dl) 8.2-10.0 7.4-10.4
Phos (mg/dl) 1.6-4.6 0.8-4.4
CPK (U/L) 70-730 0-780
LDH (U/L) 104-438 163-401
Cl (mEq/L) 90-112 89-109
Na (mEq/L) 148-154 141-153
K (mEq/L) 2.9-5.1 2.7-5.1
HDL (mg/dl) 18-102 2-98
Amylase (U/l) 117-389 45-411
Anion Gap 18-40 18-42
CO2 (mEq/l) 20-30 17-27
Iron (mcg/dl) 4-124 5-163
Lipase (U/l) 0-19 0-12
From Lab Animal Medicine ed 2
OLD WORLD NORMAL VALUES
BABOON
Hematology Serum Chemistry
Value Individual Caged Gang-caged Corralled Value Male Female
RBC x10
6
/μl 4.27-5.69 4.07-5.79 3.76-5.61 Tot bili (mg/dl) 0.0-0.4 0.1-0.3
Hgb (gm/dl) 10.6-14.4 10.3-14.9 9.5-14.5 Direct bili (mg/dl) 0.0-0.2 0.0-0.2
Hct (%) 32.4-43.5 32.5-44.9 29.0-45.2 ALT (U/L) 29-69 4-84
MCV (fl) 70.8-83.4 72.3-85.5 70.6-84.4 AST (U/L) 29-69 18-50
MCH (pg) 23.4-27.2 23.5-28.3 22.6-28.3 Alk Phos (U/L) 0-555 0-560
MCHC (gm/dl) 31.6-34.6 30.9-33.9 30.8-34.4 Creatinine (mg/dl) 0.7-1.5 0.5-1.1
WBC x10
3
/μl 3.1-15.5 3.2-17.0 1.8-27.4 Glucose (mg/dl) 65-101 40-136
Mono% 0-5 0-5 0-7 BUN (mg/dl) 9-19 7-20
Lymph % 6-66 10-88 0-49 Tot protein (gm/dl) 6.3-7.9 5.9-8.1
Neut % 32-90 9-87 47-100 Albumin (gm/dl) 2.3-5.1 1.8-4.6
Eosin % 0-3 0-4 0-2 Globulin (gm/dl) 2.3-4.7 2.8-4.6
Baso % 0 0-1 0-1 Cholesterol (mg/dl) 52-150 27-167
Platelets x10
6
/μl 164-521 150-550 104-566 GGT (U/L) 23-63 11-53
Triglycerides (mg/dl) 36-94 32-104
Ca (mg/dl) 8.2-10.0 7.4-10.4
Phos (mg/dl) 1.6-4.6 0.8-4.4
CPK (U/L) 70-730 0-780
LDH (U/L) 104-438 163-401
Cl (mEq/L) 90-112 89-109
Na (mEq/L) 148-154 141-153
K (mEq/L) 2.9-5.1 2.7-5.1
HDL (mg/dl) 18-102 2-98
Amylase (U/l) 117-389 45-411
Anion Gap 18-40 18-42
CO2 (mEq/l) 20-30 17-27
Iron (mcg/dl) 4-124 5-163
Lipase (U/l) 0-19 0-12
From Lab Animal Medicine ed 2
OLD WORLD NORMAL VALUES
RHESUS
Hematology
Value Weanlings Juvenile
Adult Male 
Indoor
Adult Male 
Outdoor
Adult Female 
Indoor
Pregant 
Female 
Geriatric 
Females
RBC x10
6
/μl 4.9-5.7 4.85-5.9 5.7-6.4 4.95-6.1 5.46-6.0 4.8-5.5 5.85-6.94
Hgb (gm/dl) 11.0-12.8 10.7-12.7 12.9-15.1 11.7-14.3 12.2-13.4 12.1-13.0 13.7-15.5
Hct (%) 34.2-39.6 32.2-38.0 42.6-49.6 35.9-44.3 38.3-42.3 34.8-38.2 41.3-47.5
MCV (fl) 66-74 61-71 72-76 67-74 67-73 68-74 67-73MCH (pg) 20.9-24.1 19.9-23.9 21.8-24.6 22.3-24.7 21.2-23.2 23.2-25.6 21.9-23.9
MCHC (gm/dl) 31.5-33.1 32.6-34.0 29.6-31.2 31.3-33.5 31.0-32.4 33.5-34.9 32.5-33.5
WBC x10
3
/μl 7.4-13.0 9.6-20.0 5.8-10.4 8.3-18.1 6.4-10.2 8.2-18.8 5.3-11.3
Mono x10
3
/μl 1-5 0-8 0-4 1-5 1-7 2-6 4-10
Lymph x10
3
/μl 49-72 17-45 38-60 16-42 33-51 9-25 26-50
Neut x10
3
/μl 25-47 46-76 34-58 54-78 43-61 68-84 39-63
Eosin x10
3
/μl 1-3 0-4 0-4 0-2 0-4 1-3 1-7
Platelets x10
6
/μl 3.54-6.52 4.47-6.47 2.97-4.99 3.13-4.57 3.56-6.54 2.46-4.56
Plasma Protein (gm/dl) 6.2-6.9 6.1-6.7 6.8-8.0 6.8-7.6 7.2-8.0 6.3-7.1 6.9-7.9
Fibrinogen (mg/dl) 100-300 100-300 100-300 100-300 100-300
OLD WORLD NORMAL VALUES
RHESUS
Serum Chemistry
Value
Adult Males 
Outdoor
Adult Male 
Indoor
Adult Female 
Indoor
Geriatric 
Females
Sodium (mM/l) 144-152 147-155 146-150 145-151
Potassium (mM/l) 3.1-4.2 4.7-5.7 4.3-5.3 4.6-5.8
Chloride (mM/l) 104-112 106-110 112-116 106-114
Total CO2 (mM/l) 18-29 21-27 22-28 20-26
Anion Gap (mM/l) 15-23 rectal temp: 99.0-102.5 F
Calcium (mM/l) 8.7-10.8 9.9-10.9 9.2-10.2 9.1-10.5 HR: 120-180bpm
Phosphorus (mg/dl) 1.4-6.4 3.8-5.6 3.4-5.4 3.1-5.5 RR: 30-70/min
Creatinine (mg/dl) 0.7-1.4 1.0-1.4 0.8-1.2 0.9-1.3 gestation: 160-170 days
BUN (mg/dl) 17-29 22-30 16-22 13-21
Glucose (mg/dl) 38-74 55-89 43-71 40-72
ALT (U/l) 1-40 24-78 26-52 41-79
Alk Phos (U/l) 0-603 55-237 91-181 98-216
Total Protein (g/dl) 5.9-7.9 7.3-8.3 7.2-8.0 6.5-7.9
Albumin (g/dl) 3.2-4.1 3.8-4.8 4.1-4.7 3.4-4.4
GGT (U/l) 21-50 51-85 48-76 35-59
CPK (U/l) 88-1796 63-237 0-436 0-3003
AST (U/l) 23-68 27-45 24-38 40-88
Tot bilirubin (mg/dl) 0-0.2 0-0.3 0.1-0.3 0.2-0.4
LDH (U/l) 193-598 223-505 217-419 216-870
Cholesterol (mg/dl) 68-190 132-190 148-200 127-187
Triglyceride (mg/dl) 11-64 72-256 18-92 40-306
From California National Primate Research Center
OLD WORLD NORMAL VALUES
CYNOMOLOGUS
Hematology Serum Chemistry
Value Adult Males Adult Females Value
Adult Females 
Indoor
RBC x10
6
/μl 6.31-7.55 5.74-6.84 Sodium (mM/l) 146-152
Hgb (gm/dl) 12.7-14.7 10.7-12.9 Potassium (mM/l) 4.6-6.2
Hct (%) 42.0-49.2 35.6-42.6 Chloride (mM/l) 108-112
MCV (fl) 63-69 58-66 Total CO2 (mM/l) 21-29
MCH (pg) 18.5-21.1 16.6-22.6 Anion Gap (mM/l)
MCHC (gm/dl) 29.1-31.1 25.8-32.8 Calcium (mM/l) 9.3-10.5
WBC x10
3
/μl 7.6-10.8 8.1-13.1 Phosphorus (mg/dl) 3.8-5.4
Mono x10
3
/μl 1-5 2-6 Creatinine (mg/dl) 0.8-1.0
Lymph x10
3
/μl 45-71 44-64 BUN (mg/dl) 21-31
Neut x10
3
/μl 23-51 31-51 Glucose (mg/dl) 43-69
Eosin x10
3
/μl 0-4 1-3 ALT (U/l) 39-95
Platelets x10
6
/μl 3.30-5.30 2.21-5.59 Alk Phos (U/l) 173-343
Plasma Protein (gm/dl) 8.1-8.9 7.5-8.7 Total Protein (g/dl) 7.3-8.3
Fibrinogen (mg/dl) 100-300 100-300 Albumin (g/dl) 4.0-4.8
GGT (U/l) 43-91
CPK (U/l) 1-2692
AST (U/l) 28-58
rectal temp: 99.0-102.5 F Tot bilirubin (mg/dl) 0.2-0.4
HR: 120-180bpm LDH (U/l) 177-566
RR: 30-70/min Cholesterol (mg/dl) 134-202
gestation: 160-170 days Triglyceride (mg/dl) 35-123
From California National Primate Research Center
REFERENCES:
Physician's Desk Reference, 55th Edition, Medical Economics Company, NJ, 2001.
Kohn, DF et al, Anesthesia and Analgesia in Laboratory Animals, Academic Press, San Diego, 1997. 
Fortman, JD et al, The Laboratory Nonhuman Primate, CRC Press, Boca Raton, 2002.
Alamogordo Primate Facility, A Charles River Company, Holloman AFB, NM 
 Dr. Julia K. Hilliard, Ph.D. Ph: 404-651-0808
 Laboratory Director Fax: 404-651-0814
 Martin J. Wildes, MT (AAB) Ph: 404-651-0792
 Laboratory Manager Fax: 404-641-0814
 Dr. Norman Bernstein, M.D. Ph: 540-374-3277
 Dr. David Davenport, M.D. Ph: 269-341-6400
Primary Clinical Consultants:
 email: ddave@chartermi.net
Atlanta, Georgia 30303
 World Wide Web site: 
 http://www.gsu.edu/bvirus
National B Virus Resource Center:
Bernacky, BJ et al, Nonhuman Primates in Laboratory Animal Medicine, 2nd Ed., eds Fox et al., Academic 
Press, San Diego, 2002.
Hawk, CT and Leary, SL, Formulary for Laboratory Animals, 2nd Ed., Iowa Stae University Press, Ames, 1999.
Primate Medicine Department, California National Primate Research Center, University of California, Davis
Flecknell, PA ed. Laboratory Animal Anaesthesia:An Introduction for Research Workers and Technicians, 
Academic Press, 1996. 
 email: bvirus@gsu.edu 
 email: mwildes@gsu.edu
National B Virus Resource Center
Viral Immunology Center
Georgia State University
50 Decatur Street

Outros materiais