Buscar

Replicação Viral - Multiplicação de Vírus - Bacteriófagos - Microbiologia

Prévia do material em texto

08/7,3/,&$¤ 2�9,5$/
2�¾FLGR�QXFOHLFR�GH�XP�YÊULRQ�FRQWÆP�VRPHQWH�XPD�SHTXHQD�TXDQWLGDGH�GRV�JHQHV�QHFHVV¾ULRV�
SDUD�D�VÊQWHVH�GH�QRYRV�YÊUXV��(QWUH�HOHV�HVWÀR�RV�JHQHV�TXH�FRGLÞFDP�RV�FRPSRQHQWHV�
HVWUXWXUDLV�GR�YÊULRQ�
ͻ
(VVDV�HQ]LPDV�VÀR�VLQWHWL]DGDV�H�IXQFLRQDP�VRPHQWH�TXDQGR�R�YÊUXV�HVW¾ GHQWUR�GD�FÆOXOD�
KRVSHGHLUD�H�HVWÀR�TXDVH�H[FOXVLYDPHQWH�HQYROYLGDV�QD�UHSOLFDÄÀR�H�QR�SURFHVVDPHQWR�GR�¾FLGR�
QXFOHLFR�
ͻ
$V�HQ]LPDV�QHFHVV¾ULDV�SDUD�D�VÊQWHVH�GH�SURWHÊQDV��RV�ULERVVRPRV��R�W51$�H�D�SURGXÄÀR�GH�
HQHUJLD�VÀR�IRUQHFLGRV�SHOD�FÆOXOD�KRVSHGHLUD�H�VÀR�XVDGRV�QD�VÊQWHVH�GH�SURWHÊQDV�YLUDLV��
LQFOXLQGR�HQ]LPDV�YLUDLV��
ͻ
(PERUD�RV�PHQRUHV�YÊULRQV�QÀR�SRVVXDP�QHQKXPD�HQ]LPD��RV�YÊULRQV�PDLRUHV�SRGHP�SRVVXLU�
XPD�RX�PDLV�HQ]LPDV�TXH�DX[LOLDP�QR�SURFHVVR�GH�SHQHWUDÄÀR�GR�YÊUXV�QD�FÆOXOD�KRVSHGHLUD�RX�
QD�UHSOLFDÄÀR�GR�¾FLGR�QXFOHLFR�YLUDO�
ͻ
$VVLP��SDUD�TXH�XP�YÊUXV�VH�PXOWLSOLTXH��HOH�SUHFLVD�LQYDGLU�D�FÆOXOD�KRVSHGHLUD�H�DVVXPLU�R�
FRPDQGR�GD�VXD�PDTXLQDULD�PHWDEÐOLFD��
ͻ
8P�×QLFR�YÊULRQ�SRGH�GDU�RULJHP��HP�XPD�×QLFD�FÆOXOD�KRVSHGHLUD��D�DOJXPDV�RX�PHVPR�
PLOKDUHV�GH�SDUWÊFXODV�YLUDLV�LJXDLV��(VVH�SURFHVVR�SRGH�DOWHUDU�GUDVWLFDPHQWH�D�FÆOXOD�
KRVSHGHLUD��SRGHQGR�FDXVDU�VXD�PRUWH��(P�DOJXPDV�LQIHFÄÒHV�YLUDLV��D�FÆOXOD�VREUHYLYH�H�
FRQWLQXD�D�SURGX]LU�YÊUXV�LQGHÞQLGDPHQWH�
ͻ
08/7,3/,&$¤ 2�'(�%$&7(5,°)$*26
2�PHFDQLVPR�E¾VLFR�GH�PXOWLSOLFDÄÀR�YLUDO�Æ VLPLODU�SDUD�WRGRV�RV�YÊUXV��ͻ
2V�EDFWHULÐIDJRV�SRGHP�PXOWLSOLFDU�VH�SRU�GRLV�PHFDQLVPRV�DOWHUQDWLYRV��R�FLFOR�OÊWLFR�H�R�FLFOR�
OLVRJÇQLFR��2�FLFOR�OÊWLFR�WHUPLQD�FRP�D�OLVH�H�PRUWH�GD�FÆOXOD�KRVSHGHLUD��M¾�QR�FLFOR�OLVRJÇQLFR�D�
FÆOXOD�KRVSHGHLUD�SHUPDQHFH�YLYD�
ͻ
��9LVWR�TXH�RV�EDFWHULÐIDJRV�7�SDUHV��7���7��H�7���VÀR�RV�PDLV�HVWXGDGRV��GHVFUHYHUHPRV�VXD�
PXOWLSOLFDÄÀR�HP�VHX�KRVSHGHLUR�(��FROL��FRPR�XP�H[HPSOR�GH�FLFOR�OÊWLFR�
%DFWHULÐIDJRV�7�SDUHV�� 2�&,&/2�/ª7,&2�� QR�FLFOR�OÊWLFR��R�YÊUXV�LQVHUH�R�VHX�PDWHULDO�JHQÆWLFR�
QR�GD�FÆOXOD�KRVSHGHLUD�H�SDVVD�D�GRPLQDU�R�PHWDEROLVPR�GD�FÆOXOD��GHVWUXLQGR�D�QR�ÞQDO�GR�
SURFHVVR��9ÊULRQV�GRV�EDFWHULÐIDJRV�7�SDUHV�VÀR�JUDQGHV��FRPSOH[RV�H�QÀR�HQYHORSDGRV��H�
DSUHVHQWDP�XPD�HVWUXWXUD�FDUDFWHUÊVWLFD�GH�FDEHÄD�H�FDXGD��2�FLFOR�GH�PXOWLSOLFDÄÀR�GHVVHV�
IDJRV��DVVLP�FRPR�R�GH�WRGRV�RV�RXWURV�YÊUXV��RFRUUH�HP�FLQFR�HWDSDV�GLVWLQWDV�
ͻ
$GVRUÄÀR�RX�$GHVÀR� DFRQWHFH�DSÐV�XPD�FROLVÀR�DR�DFDVR�HQWUH�DV�SDUWÊFXODV�GR�IDJR�
�EDFWHULÐIDJR��H�GD�EDFWÆULD��'XUDQWH�HVVH�SURFHVVR��XP�VÊWLR�GH�DGHVÀR��UHFHSWRU��QR�YÊUXV�OLJD�
VH�DR�VÊWLR�GR�UHFHSWRU�FRPSOHPHQWDU�QD�FÆOXOD�EDFWHULDQD��2V�EDFWHULÐIDJRV�7�SDUHV�SRVVXHP�
ÞEUDV�QD�H[WUHPLGDGH�GD�FDXGD��TXH�DWXDP�FRPR�VÊWLRV�GH�DGHVÀR��2V�UHFHSWRUHV�
FRPSOHPHQWDUHV�HVWÀR�QD�SDUHGH�GD�FÆOXOD�EDFWHULDQD�
�
9¯UXV�� 3DUWH��
ƋƵŝŶƚĂͲĨĞŝƌĂ͕�ϭϵ�ĚĞ�ĂŐŽƐƚŽ�ĚĞ�ϮϬϮϭ ϮϮ͗ϮϬ
3HQHWUDÄÀR� DSÐV�D�DGVRUÄÀR��RV�EDFWHULÐIDJRV�7�SDUHV�LQMHWDP�VHX�'1$��¾FLGR�QXFOHLFR��GHQWUR�
GD�EDFWÆULD��3DUD�LVVR��D�FDXGD�GR�EDFWHULÐIDJR�OLEHUD�XPD�HQ]LPD��D�OLVR]LPD�I¾JLFD��TXH�GHJUDGD�
XPD�SRUF �ÀR�GD�SDUHGH�FHOXODU�EDFWHULDQD��'XUDQWH�R�SURFHVVR�GH�SHQHWUDÄÀR��D�EDLQKD�GD�FDXGDࡤ
GR�IDJR�VH�FRQWUDL��H�R�FHQWUR�GD�FDXGD�DWUDYHVVD�D�SDUHGH�GD�FÆOXOD�EDFWHULDQD��4XDQGR�R�FHQWUR�
GD�FDXGD�DOFDQÄD�D�PHPEUDQD�SODVP¾WLFD��R�'1$�GD�FDEHF ��D�GR�IDJR�SHQHWUD�QD�EDFWÆULDࡤ
DWUDYHVVDQGR�R�O×PHQ�GD�FDXGD�H�GD�PHPEUDQD�SODVP¾WLFD��2�FDSVÊGHR�SHUPDQHFH�GR�ODGR�GH�
IRUD�GD�FÆOXOD�EDFWHULDQD��3RUWDQWR��D�SDUWÊFXOD�GR�IDJR�IXQFLRQD�FRPR�XPD�VHULQJD�KLSRGÆUPLFD��
LQMHWDQGR�R�¾FLGR�QXFOHLFR��TXH��QHVVH�FDVR��Æ�R�'1$��GHQWUR�GD�FÆOXOD�EDFWHULDQD�
�
%LRVVÊQWHVH� DVVLP�TXH�R�'1$�GR�EDFWHULÐIDJR�DOFDQÄD�R�FLWRSODVPD�GD�FÆOXOD�KRVSHGHLUD��RFRUUH�
D�ELRVVÊQWHVH�GR�¾FLGR�QXFOHLFR�H�GDV�SURWHÊQDV�YLUDLV��$�VÊQWHVH�SURWHLFD�GR�KRVSHGHLUR�Æ
LQWHUURPSLGD�SHOD�GHJUDGDÄÀR�GR�VHX�'1$�LQGX]LGD�SHOR�YÊUXV��SHOD�DÄÀR�GH�SURWHÊQDV�YLUDLV�TXH�
LQWHUIHUHP�FRP�D�WUDQVFULÄÀR��RX�SHOD�LQLELÄÀR�GD�WUDGXÄÀR��,QLFLDOPHQWH��R�IDJR�XWLOL]D�RV�
QXFOHRWÊGHRV�H�Y¾ULDV�HQ]LPDV�GD�FÆOXOD�KRVSHGHLUD�SDUD�VLQWHWL]DU�PXLWDV�FÐSLDV�GH�VHX�'1$��
/RJR�HP�VHJXLGD��LQLFLD�VH�D�ELRVVÊQWHVH�GDV�SURWHÊQDV�YLUDLV��7RGR�R�51$�WUDQVFULWR�QD�FÆOXOD�
FRUUHVSRQGH�DR�P51$�WUDQVFULWR�D�SDUWLU�GR�'1$�GR�IDJR�SDUD�D�VÊQWHVH�GH�HQ]LPDV�YLUDLV�H�GDV�
SURWHÊQDV�GR�FDSVÊGHR�YLUDO��2X�VHMD��R�P51$�GD�FÆOXOD�KRVSHGHLUD�Æ�XWLOL]DGR�QD�VÊQWHVH�GH�
HQ]LPDV�H�SURWHÊQDV�YLUDLV��DWUDYÆV�GR�¾FLGR�QXFOHLFR�GR�YÊUXV��2V�ULERVVRPRV��DV�HQ]LPDV�H�RV�
DPLQR¾FLGRV�GD�FÆOXOD�KRVSHGHLUD�VÀR�XVDGRV�QD�WUDGXÄÀR�
�
� 'XUDQWH�Y¾ULRV�PLQXWRV�DSÐV�D�LQIHFÄÀR��RV�IDJRV�FRPSOHWRV�QÀR�SRGHP�VHU�HQFRQWUDGRV�QD�FÆOXOD�
KRVSHGHLUD��6RPHQWH�FRPSRQHQWHV�LVRODGRV�t '1$�H�SURWHÊQD�t SRGHP�VHU�GHWHFWDGRV��2�SHUÊRGR�GD�
PXOWLSOLFDF ÀR�YLUDO�QR�TXDO�YÊULRQV�FRPSOHWRV�H�LQIHFFLRVRV�DLQGD�QÀR�VÀR�HQFRQWUDGRV�Æࡤ FKDPDGR�GH�
SHUÊRGR�GH�HFOLSVH�
0DWXUDÄÀR� GXUDQWH�HVVH�SURFHVVR��YÊULRQV�FRPSOHWRV�VÀR�IRUPDGRV�D�SDUWLU�GR�'1$�H�GRV�
FDSVÊGHRV�GR�EDFWHULÐIDJR��2V�FRPSRQHQWHV�YLUDLV�VH�RUJDQL]DP�HVSRQWDQHDPHQWH�SDUD�IRUPDU�D�
SDUWÊFXOD�YLUDO��$V�FDEHF �DV�H�DV�FDXGDV�GRV�IDJRV�VÀR�PRQWDGDV�VHSDUDGDPHQWH�D�SDUWLU�GHࡤ
VXEXQLGDGHV�GH�SURWHÊQDV��D�FDEHÄD�UHFHEH�R�'1$�YLUDO�H�VH�OLJD�½ FDXGD�
�
/LEHUDÄÀR� FRQVLVWH�QD�OLEHUDÄÀR�GRV�YÊULRQV�GD�FÆOXOD�KRVSHGHLUD��$�PHPEUDQD�SODVP¾WLFD�VHU¾�
URPSLGD�SDUD�OLEHUDU�RV�YÊULRQV��LVVR�DFRQWHFH�DWUDYÆV�GD�DÄÀR�GD�/LVR]LPD��$�/LVR]LPD��
FRGLILFDGD�SRU�XP�JHQH�YLUDO��Æ�VLQWHWL]DGD�GHQWUR�GD�FÆOXOD��(VVD�HQ]LPD�GHVWUÐL�D�SDUHGH�FHOXODU�
EDFWHULDQD��OLEHUDQGR�RV�QRYRV�EDFWHULÐIDJRV�SURGX]LGRV��2V�QRYRV�EDFWHULÐIDJRV�LQIHFWDP�RXWUDV�
FÆOXODV�H�R�FLFOR�VH�UHSHWH�
�
� &RPR�H[HPSOR�GH�FLFOR�OLVRJÇQLFR��VHU¾�XWLOL]DGR�R�EDFWHULÐIDJR�/DPEGD�
%DFWHULÐIDJR�/DPEGD�� 2�&,&/2�/,62*§1,&2� QHVVD�IRUPD�GH�UHSURGXÄÀR��R�YÊUXV�QÀR�FDXVD�
D�OLVH�H�D�PRUWH�GD�FÆOXOD�KRVSHGHLUD��1D�OLVRJHQLD��R�IDJR�SHUPDQHFH�ODWHQWH �LQDWLYR���$V�
FÆOXODV�EDFWHULDQDV�KRVSHGHLUDV�VÀR�FKDPDGDV�GH�FÆOXODV�OLVRJÇQLFDV�
ͻ
$SÐV�D�SHQHWUDÄÀR�QD�FÆOXOD�EDFWHULDQD��R�'1$��¾FLGR�QXFOHLFR��GR�IDJR��RULJLQDOPHQWH�OLQHDU��
DGRWD�R�IRUPDWR�GH�XP�FÊUFXOR�TXH�SRGH�VH�PXOWLSOLFDU�H�VHU�WUDQVFULWR��OHYDQGR�D�IRUPDÄÀR�GH�
QRYRV�IDJRV�H�½�OLVH�FHOXODU��FLFOR�OÊWLFR���2X�R�'1$�SRGH�VH�UHFRPELQDU�FRP�R�'1$�EDFWHULDQR�H�
VH�WRUQDU�SDUWH�GHOH��FLFOR�OLVRJÇQLFR��
�
2X�VHMD��DSÐV�R�YÊUXV�SHQHWUDU�D�PHPEUDQD�GD�FÆOXOD�H�VHX�¾FLGR�QXFOHLFR�HQWUDU�QD�FÆOXOD��HOH�
SRGH�VHJXLU�R�FLFOR�OÊWLFR�RX�R�OLVRJÇQLFR�
�
� 2�'1$�GR�IDJR�LQVHULGR�QR�FURPRVVRPR�EDFWHULDQR�Æ�FKDPDGR�GH 3UÐIDJR�
1R�FLFOR�OLVRJÇQLFR��D�PDLRULD�GRV�JHQHV�GR�SUÐIDJR�VÀR�UHSULPLGRV�SRU�SURWHÊQDV�UHSUHVVRUDV��
(VVHV�UHSUHVVRUHV�LQWHUURPSHP�D�WUDQVFULÄÀR�GH�WRGRV�RV�RXWURV�JHQHV�GR�IDJR��$VVLP��RV�JHQHV�
GR�IDJR�TXH�SRGHULDP�GLUHFLRQDU�SDUD�D�VÊQWHVH�GH�QRYRV�YÊULRQV�VÀR�GHVOLJDGRV�
�
(QWÀR�R�'1$�GR�IDJR��SUÐIDJR��VH�PXOWLSOLFD�MXQWR�DR�'1$�GD�FÆOXOD�EDFWHULDQD�KRVSHGHLUD�H�ILFD�
LQDWLYR��ODWHQWH��
�
6HPSUH�TXH�D�PDTXLQDULD�FHOXODU�UHSOLFDU�R�FURPRVVRPR�EDFWHULDQR��R�'1$�GR�IDJR�WDPEÆP�
VHU¾�UHSOLFDGR��2�SUÐIDJR�SHUPDQHFH�ODWHQWH�
�
2�SUÐIDJR�ILFD�LQDWLYR�QR�VHQWLGR�GH�QÀR�IRUPDU�QRYRV�YÊUXV�SURSULDPHQWH��PDV�HOH�Æ�FDSD]�GH�
PXGDU�DOJXPDV�IXQÄÒHV�H�SURSULHGDGHV�GD�FÆOXOD�TXH�IRL�LQIHFWDGD�
�
5(6802�'2�&�3,78/2����'2�/,952�¾
1MGVSFMSPSKME�� ��l�)H�������� 8SVXSVE��+IVEVH�.��*YROI��&IVHIPP�6��'EWI��
'LVMWXMRI�0��

Outros materiais

Materiais relacionados

Perguntas relacionadas

Perguntas Recentes