Human Transgenesis - Definitions Technical Possibilities and Moral Challenges
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beings, not a qualitative one.4 The problem does not lie in the tool itself, but in what use people will make of it. 4 Conclusion The biological and social possibilities that transgenic interventions may bring about are further evidence that reality is complex, dynamic and uncertain: The deeper our grasp of reality, the more we realise that there are no essences to be found, no underlying intentionality to be followed, and no holiness to be respected. Even as the concept of human nature dissolves into nothingness, the uniqueness and capacity of human agency is increased. Taking control of and responsibility for our evolu- tionary future means recognising and assessing genuine risks, not retreating behind obsolete notions concerning the essentialistic qualities of the human genome or the purported wisdom of the evolutionary process. It is time that we recognise trans- genesis as an eminently natural process, one that plays an important role in the development and evolution of all species, including Homo sapiens. Acknowledgements Brunello Stancioli acknowledges the support of CAPES – as a beneficiary of one of its scholarships for post-doctoral studies abroad – for his work on this article. References Aiuti, A., et al. (2002). Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloa- blative conditioning. Science, 296, 2410–2413. Akiba, T., et al. (1960). On the mechanism of the development of multiple-drug-resistant clones of Shigella. Japanese Journal of Microbiology, 4, 219–227. 4 Take, for instance, a hypothetical transgenic intervention that would cause the growth of an extra arm and a brain–machine interface integration that would allow the exact same change to occur by different means (cf. O'Doherty et al. 2011). F.G. da Fonseca et al. Akinci, B., et al. (2010). Allergic reactions to human insulin: a review of current knowledge and treatment options. Endocrine, 37(1), 33–39. Andam, C. P., Williams, D., & Gogarten, J. P. (2010). Natural taxonomy in light of horizontal gene transfer. Biology and Philosophy, 25, 589–602. Belshaw, R., et al. (2004). Long-term reinfection of the human genome by endogenous retroviruses. Proceedings of the National Academy of Sciences of the USA, 101(14), 4894–4899. Biotechnology Industry Organization—BIO. (2010). Healing, fueling, feeding: how biotechnology is enriching your life. http://www.valueofbiotech.com/sites/default/files/pdfs/ValueofBiotechFINAL.pdf. Accessed 26 April 2012. Boecio. (2005). Escritos (Opuscala Sacra). São Paulo: Martins Fontes. Bostrom, N., & Sandberg, A. (2009). The wisdom of nature: an evolutionary heuristic for human enhancement. In J. Savulescu & N. Bostrom (Eds.), Human enhancement (pp. 375–416). Oxford: Oxford University Press. Brem, S. K., & Anijar, K. Z. (2003). The bioethics of fiction: the chimera in film and print. The American Journal of Bioethics, 3(3), 22–24. Cavazzana-Calvo, M., et al. (2000). Gene therapy of human severe combined immunodeficiency (SCID)- X1 disease. Science, 288, 669–672. Check, E. (2005). Gene therapy put on hold as third child develops cancer. Nature, 433, 561. Choi, C. (2006). Transgenic drug market heats up. The Scientist, Aug. 3rd. Chou, H. H., et al. (2002). Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proceedings of the National Academy of Sciences of the USA, 99, 11736–11741. Cockrell, A. S., &Kafri, T. (2007). Gene delivery by lentivirus vectors.Molecular Biotechnology, 36, 184–204. Cordaux, R., & Batzer, M. A. (2009). The impact of retrotransposons on human genome evolution. Nature Reviews Genetics, 10(10), 691–703. Daniels, S. B., et al. (1990). Evidence for horizontal transmission of the P transposable element between Drosophila species. Genetics, 124(2), 339–355. della Mirandola, G. P. (1994). Oratio de hominis dignitate. Pordenone: Edizioni Studio Tesi. Doolittle, W. F., & Bapteste, E. (2007). Pattern pluralism and the tree of life hypothesis. Proceedings of the National Academy of Sciences of the USA, 104, 2043–2049. EFSA, GMO Panel Working Group on Animal Feeding Trials. (2008). Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. Food and Chemical Toxicology, 46(Suppl 1), S2–S70. Faulkner, G. J. (2011). Retrotransposons: mobile and mutagenic from conception to death. FEBS Letters, 585(11), 1589–1594. Gilbert, C., et al. (2010). A role for host-parasite interactions in the horizontal transfer of transposons across phyla. Nature, 464(7293), 1347–1350. Hohmann-Marriott, M. F., & Blankenship, R. E. (2011). Evolution of photosynthesis. Annual Review of Plant Biology, 62, 20.1–20.34. Hug, K. (2008). Genetically modified organisms: do the benefits outweigh the risks? Medicina (Kaunas, Lithuania), 44(2), 87–99. Karpowicz, P. (2003). In defense of stem cell chimeras: a response to “crossing species boundaries”. The American Journal of Bioethics, 3(3), 17–19. Kawase, Y. (2011). Rescuing the failing heart by targeted gene transfer. Journal of the American College of Cardiology, 57, 1169–1180. Keeling, P. J. (2009). Functional and ecological impacts of horizontal gene transfer in eukaryotes. Current Opinion in Genetics & Development, 19, 613–619. Keeling, P. J., & Palmer, J. D. (2008). Horizontal gene transfer in eukaryotic evolution. Nature Reviews Genetics, 9(8), 605–618. Konkel, M. K., & Batzer, M. A. (2010). A mobile threat to genome stability: the impact of non-LTR retrotransposons upon the human genome. Seminars in Cancer Biology, 20(4), 211–221. Koonin, E. V., Makarova, K. S., & Aravind, L. (2001). Horizontal gene transfer in prokaryotes: quantifi- cation and classification. Annual Review of Microbiology, 55, 709–742. Lander, E. S., et al. (2001). Initial sequencing and analysis of the human genome. Nature, 409, 860–921. Levasseur, D. N., et al. (2003). Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood, 102, 4312– 4319. Mostoslavsky, G., et al. (2006). Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proceedings of the National Academy of Sciences of the USA, 103, 16406–16411. Human Transgenesis: Technical Possibilities and Moral Challenges Nyberg, K., et al. (2004). Workshop on long-term follow-up of participants in human gene transfer research. Molecular Therapy, 10, 976–980. O'Doherty, et al. (2011). Active tactile exploration using a brain–machine–brain interface. Nature, 479, 228–231. Ott, M. G., et al. (2006). Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nature Medicine, 12, 401–409. Pinstrup-Andersen, P., & Schioler, E. (2000). Seeds of contention. Baltimore: Johns Hopkins University Press (International Food Policy Research Institute). Powell, R., & Buchanan, A. (2011). Breaking evolution's chains: the promise of enhancement by design. In J. Savulescu, R. ter Meulen, & G. Kahane (Eds.), Enhancing human capacities (p. 64). Oxford: Blackwell. Raven, P. H. (2010). Does the use of transgenic plants diminish or promote biodiversity? New Biotech- nology, 27(5), 528–533. Sagoff, M. (2005). Nature and human nature. In H. W. Baillie & T. K. Casey (Eds.), Is human nature obsolete? Genetics, bioengineering and the future of the human condition (pp. 67–98). Cambridge: The MIT Press. Savulescu, J., Sandberg, A., & Kahane, G. (2011). Well-being and enhancement. In J. Savulescu, R. ter Meulen, & G. Kahane (Eds.), Enhancing human capacities (p. 7). Oxford: Blackwell. Schaack, S., Gilbert, C., & Feschotte, C. (2010). Promiscuous DNA: horizontal transfer of transposable elements and why it matters for eukaryotic evolution. Trends in Ecology & Evolution, 25(9), 537–546. Shrader-Frechette, K. (2005). Property rights and genetic engineering: developing nations at risk.