A maior rede de estudos do Brasil

Grátis
5 pág.
Aula+de+Fatores

Pré-visualização | Página 1 de 1

Cálculos
� Fatores
� Equivalência
� Correção
• antibióticos• antibióticos
� Umidade
� Objetivo: ajustar massa a ser pesada de cada um dos 
fármacos
Cálculos
� Fator de equivalência
Eq
base
sal
Eq
Eq
Feq =
Cálculos
� Cloridrato de fluoxetina
� Massa do sal: 345,8g/mol
� Massa da base: 309,3g/mol
� Índice� Índice
� Feq = 1,12
� Referência: Prozac
fluoxetina
fluoxetinadecloridrato
Eq
Eq
Feq __=
Cálculos
� Cloridrato de propranolol
� Massa do sal: 295,8g/mol
� Massa da base: 259,3g/mol
� Índice� Índice
� Feq = ?
� Referência: Inderal
lpropranolo
lpropranolodecloridrato
Eq
Eq
Feq __=
Cálculos
� Cloridrato de ranitidina
� Massa do sal: 350,9g/mol
� Massa da base: 314,4g/mol
� Índice� Índice
� Feq = 1,12
� Referência: Antak
ranitidina
ranitidinadecloridrato
Eq
Eq
Feq __=
Cálculos
� Sulfato de salbutamol
� Massa do sal (C13H21NO3)2.H2SO4 : 576,70g/mol
� Massa da base (C13H21NO3) 239,3g/mol
� Índice� Índice
� Feq = 1,20
� Referência: Aerolin
salbutamol
salbutamoldeSulfato
Eq
Eq
Feq __=
Cálculos Cálculos
� Fator de correção: Teor
� Omeprazol 10%
� betacaroteno 11%� betacaroteno 11%
� Ativos a 98%
� Ácido glicólico 70%
� Finasterida 1mg (20 cápsulas)
Cálculos
� Fator de correção: Potência
� Azitromicina
• Azithromycin contains one or two molecules of water of hydration. 
It contains USP28 the equivalent of not less than 945 µg and not 
more than 1030 µg of azithromycin (C38H72N2O12 ) per mg, 
calculated on the anhydrous basis.
• Water: between 4.0% and 5.0% where it is labeled as the 
dihydrate; between 1.8% and 4.0% where it is labeled as the 
monohydrate.
Cálculos
� Fator de correção: Potência
� Neomicina
• Neomycin Sulfate is the sulfate salt of a kind of neomycin, an 
antibacterial substance produced by the growth of Streptomyces
fradiae Waksman (Fam. Streptomycetaceae), or a mixture of two 
or more such salts. It has a potency equivalent to not less than 
600 µg of neomycin per mg, calculated on the dried basis.
Cálculos
� Fator de correção: Potência
� Eritromicina (estearato)
• Erythromycin Stearate is the stearic acid salt of Erythromycin, 
with an excess of Stearic Acid. The sum of the percentages of 
erythromycin A, erythromycin B, and erythromycin C is not less 
than 55.0 percent, calculated on the anhydrous basis.
• Water: not more than 4.0%
Cálculos
� Fator de correção: Potência
� Claritromicina
• Clarithromycin contains not less than 960 µg and not more than 
1040 µg of C38H69NO13 per mg, calculated on the anhydrous 
basis.
• Water: not more than 2.0%.
Cálculos
� Fator de correção: Potência
� Cefalexina
• Cephalexin has a potency of not less than 950 µg and not more 
than 1030 µg of C16H17N3O4S per mg, calculated on the 
anhydrous basis.
• Water: between 4.0% and 8.0%
Cálculos
� Fator de correção: Potência
� Cefalexina cloridrato
• Cephalexin Hydrochloride contains the equivalent of not less than 
800 µg and not more than 880 µg of cephalexin (C16H17N3O4S) 
per mg.
• Water: between 3.0% and 6.5%.
Cálculos
Cálculos
� Fator de umidade: água
� Amoxicilina
• contains not less than 900 µg and not more than 1050 µg of 
C16H19N3O5S per mg, calculated on the anhydrous basis.
• Water: between 11.5% and 14.5%.
• Massa molar anidra (C16H19N3O5S ): 364,5g/mol
• Massa molar trihidratada (C16H19N3O5S. 3H2O ): 418,5g/mol
Cálculos
� Fator de correção
� Nistatina
• Nystatin is a substance, or a mixture of two or more substances, • Nystatin is a substance, or a mixture of two or more substances, 
produced by the growth of Streptomyces noursei Brown et al. 
(Fam. Streptomycetaceae). It has a potency of not less than 4400 
USP Nystatin Units per mg, or, where intended for use in the 
extemporaneous preparation of oral suspensions, not less than 
5000 USP Nystatin Units per mg.