Aula+de+Fatores
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Aula+de+Fatores


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Cálculos
\ufffd Fatores
\ufffd Equivalência
\ufffd Correção
\u2022 antibióticos\u2022 antibióticos
\ufffd Umidade
\ufffd Objetivo: ajustar massa a ser pesada de cada um dos 
fármacos
Cálculos
\ufffd Fator de equivalência
Eq
base
sal
Eq
Eq
Feq =
Cálculos
\ufffd Cloridrato de fluoxetina
\ufffd Massa do sal: 345,8g/mol
\ufffd Massa da base: 309,3g/mol
\ufffd Índice\ufffd Índice
\ufffd Feq = 1,12
\ufffd Referência: Prozac
fluoxetina
fluoxetinadecloridrato
Eq
Eq
Feq __=
Cálculos
\ufffd Cloridrato de propranolol
\ufffd Massa do sal: 295,8g/mol
\ufffd Massa da base: 259,3g/mol
\ufffd Índice\ufffd Índice
\ufffd Feq = ?
\ufffd Referência: Inderal
lpropranolo
lpropranolodecloridrato
Eq
Eq
Feq __=
Cálculos
\ufffd Cloridrato de ranitidina
\ufffd Massa do sal: 350,9g/mol
\ufffd Massa da base: 314,4g/mol
\ufffd Índice\ufffd Índice
\ufffd Feq = 1,12
\ufffd Referência: Antak
ranitidina
ranitidinadecloridrato
Eq
Eq
Feq __=
Cálculos
\ufffd Sulfato de salbutamol
\ufffd Massa do sal (C13H21NO3)2.H2SO4 : 576,70g/mol
\ufffd Massa da base (C13H21NO3) 239,3g/mol
\ufffd Índice\ufffd Índice
\ufffd Feq = 1,20
\ufffd Referência: Aerolin
salbutamol
salbutamoldeSulfato
Eq
Eq
Feq __=
Cálculos Cálculos
\ufffd Fator de correção: Teor
\ufffd Omeprazol 10%
\ufffd betacaroteno 11%\ufffd betacaroteno 11%
\ufffd Ativos a 98%
\ufffd Ácido glicólico 70%
\ufffd Finasterida 1mg (20 cápsulas)
Cálculos
\ufffd Fator de correção: Potência
\ufffd Azitromicina
\u2022 Azithromycin contains one or two molecules of water of hydration. 
It contains USP28 the equivalent of not less than 945 µg and not 
more than 1030 µg of azithromycin (C38H72N2O12 ) per mg, 
calculated on the anhydrous basis.
\u2022 Water: between 4.0% and 5.0% where it is labeled as the 
dihydrate; between 1.8% and 4.0% where it is labeled as the 
monohydrate.
Cálculos
\ufffd Fator de correção: Potência
\ufffd Neomicina
\u2022 Neomycin Sulfate is the sulfate salt of a kind of neomycin, an 
antibacterial substance produced by the growth of Streptomyces
fradiae Waksman (Fam. Streptomycetaceae), or a mixture of two 
or more such salts. It has a potency equivalent to not less than 
600 µg of neomycin per mg, calculated on the dried basis.
Cálculos
\ufffd Fator de correção: Potência
\ufffd Eritromicina (estearato)
\u2022 Erythromycin Stearate is the stearic acid salt of Erythromycin, 
with an excess of Stearic Acid. The sum of the percentages of 
erythromycin A, erythromycin B, and erythromycin C is not less 
than 55.0 percent, calculated on the anhydrous basis.
\u2022 Water: not more than 4.0%
Cálculos
\ufffd Fator de correção: Potência
\ufffd Claritromicina
\u2022 Clarithromycin contains not less than 960 µg and not more than 
1040 µg of C38H69NO13 per mg, calculated on the anhydrous 
basis.
\u2022 Water: not more than 2.0%.
Cálculos
\ufffd Fator de correção: Potência
\ufffd Cefalexina
\u2022 Cephalexin has a potency of not less than 950 µg and not more 
than 1030 µg of C16H17N3O4S per mg, calculated on the 
anhydrous basis.
\u2022 Water: between 4.0% and 8.0%
Cálculos
\ufffd Fator de correção: Potência
\ufffd Cefalexina cloridrato
\u2022 Cephalexin Hydrochloride contains the equivalent of not less than 
800 µg and not more than 880 µg of cephalexin (C16H17N3O4S) 
per mg.
\u2022 Water: between 3.0% and 6.5%.
Cálculos
Cálculos
\ufffd Fator de umidade: água
\ufffd Amoxicilina
\u2022 contains not less than 900 µg and not more than 1050 µg of 
C16H19N3O5S per mg, calculated on the anhydrous basis.
\u2022 Water: between 11.5% and 14.5%.
\u2022 Massa molar anidra (C16H19N3O5S ): 364,5g/mol
\u2022 Massa molar trihidratada (C16H19N3O5S. 3H2O ): 418,5g/mol
Cálculos
\ufffd Fator de correção
\ufffd Nistatina
\u2022 Nystatin is a substance, or a mixture of two or more substances, \u2022 Nystatin is a substance, or a mixture of two or more substances, 
produced by the growth of Streptomyces noursei Brown et al. 
(Fam. Streptomycetaceae). It has a potency of not less than 4400 
USP Nystatin Units per mg, or, where intended for use in the 
extemporaneous preparation of oral suspensions, not less than 
5000 USP Nystatin Units per mg.