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ROSA MARTHA PEREZ GUTIERREZ 
Investigador Titular C 
SNI: III. 
Laboratorio: Investigación de Productos Naturales 
Extensión: 55142 
E-mail: rmpg@prodigy.net.mx 
 
 
 
Formación académica: 
Doctora en Ciencias Biológicas. Universidad Autónoma Metropolitana-Xochimilco 
 
Líneas de Investigación: 
Estudio químico de compuestos bioactivos de plantas, síntesis de nanopartículas con bioactivos 
de plantas y su estudio farmacológico 
Formación de Recursos Humanos: 
 
 Licenciatura Maestría Doctorado 
 38 21 2 
 
Total de artículos: 193 
 
Ultimas publicaciones 2014-2017: 
 
1. Rosa Martha Perez Gutierrez, Diana Madrigales Ahuatzi, María del Carmen Horcacitas. Efren García Baez, 
Tereza Cruz Victoria, Jose María Mota Flores. (2014) Antiobesity and antidiabetic effects of the hexane extract 
from Phalaris canariensis in high-fat diet-induced obese mice and streptozotocin-induced diabetic mice. Evid Based 
Complement Alternat Med. 2014, Article ID 145901, 13 pages, doi:10.1155/2014/145901. 
2. Rosa Martha Perez Gutierrez, Jose Maria Mota Flores (2014) Effect of chronic administration of hexane extract 
of Byrsonima crassifolia seed on β-cell and pancreatic oxidative parameters in streptozotocin-induced diabetic rat. 
African Journal of Traditional, Complementary and Alternative medicines. 11(2), 231-236. 
3.Alethia Muñiz-Ramirez, Rosa Martha Perez Gutierrez, Efren Garcia Baez, Jose Maria Mota Flores. (2014). 
Antimicrobial activities of diterpene labdane from seeds of Byrsonima crassifolia. Bol. Latin. y del Caribe de 
Plantas Medicinales y Aromáticas.13(1)31-3769 –3780 
4.Rosa Martha Perez Gutierrez, Efren Garcia Baez. (2014). Evaluation of hypoglycemic, antioxidant and 
antiglycating activities of the Eysenhardtia polystachya. Phcog Mag, April - June (Supplement 2) 10(38)S404-
S418. 
5.Rosa Martha Perez Gutierrez, Maria de Jesus Martinez Ortiz (2014). Beneficial effect of Azadirachta indica on 
advanced glycation end-product in streptozotocin-diabetic rat. Pharmaceutical Biology, 52(11)1435-1444; DOI: 
10.3109/13880209.2014.895389 
6.Rosa Martha Perez Gutierrez (2014). Effect of Mexican oregano (Lippia graveolens Kunth) on streptozotocin 
induced diabetic mice and its role in regulating carbohydrate metabolic enzymes and their inhibitory effect on the 
formation of advanced glycation end products. Annual Review & Research in Biology. 4(23), 3470-3491. 
7.Adriana María Neira Gonzalez, Rosa Martha Perez Gutierrez, Luis Bernardo Flores Cotera (2014). Antidiabetic 
activity of Piper auritum leaves in streptozotocin-induced diabetic rat, beneficial effect on advanced glycation 
endproduct. Chinese Journal of Integrative Medicine. (DOI) 10.1007/s11655-014-1753-2 
8.Rosa Martha Perez Gutierrez, Vicente aguiñiga Juarez, Jahel Valdes Sauceda, Irasema Anaya Sosa. (2014). In 
vitro and in vivo antidiabetic and antiglication properties of Apium graveolens in Type 1 and 2 diabetic rats. 
International Journal of Pharmacology. DOI: 10.3923/IJP.2014. 
9.Rosa Martha Perez Gutierrez, Alethia Muñiz Ramírez, Jahel Valdes Sauceda (2015). Review: The potential of 
chalcones as a source of drugs. Afr J Pharm Pharmacol. 9(8): 237-257. 
mailto:rmpg@prodigy.net.mx
http://www.ncbi.nlm.nih.gov/pubmed/?term=Antiobesity+and+antidiabetic++Phalaris+canariensis+in+high-fat+diet-induced+obese+mice+and+streptozotocin-induced+diabetic+mice.+Evidence-Based+Complementary+and+Alternative+Medicine%2C+vol.+2014%2C+Article+ID+145901%2C+13+pages%2C+doi%3A10.1155%2F2014%2F145901.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Antiobesity+and+antidiabetic++Phalaris+canariensis+in+high-fat+diet-induced+obese+mice+and+streptozotocin-induced+diabetic+mice.+Evidence-Based+Complementary+and+Alternative+Medicine%2C+vol.+2014%2C+Article+ID+145901%2C+13+pages%2C+doi%3A10.1155%2F2014%2F145901.
http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/2263
http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/2263
http://link.springer.com/article/10.1007/s11418-011-0519-9
http://link.springer.com/article/10.1007/s11418-011-0519-9
http://link.springer.com/search?facet-author=%22Adriana+Mar%C3%ADa+Neira+Gonzalez%22
http://link.springer.com/search?facet-author=%22Rosa+Martha+Perez+Gutierrez%22
http://link.springer.com/search?facet-author=%22Luis+Bernardo+Flores+Cotera%22
http://link.springer.com/journal/11655
http://link.springer.com/search?facet-author=%22Rosa+Martha+Perez+Gutierrez%22
http://link.springer.com/search?facet-author=%22Rosa+Martha+Perez+Gutierrez%22
10.Rosa Martha Perez Gutierrez (2015). Evaluation of anti-inflammatory activity of the bark of Eysenhardtia 
polystachya in experimental animal models. African Journal of Pharmacy and Pharmacology.9(8). 230-236. 
11. Rosa Martha Perez-Gutierrez, Diana Madrigales-Ahuatzi, (2015). Investigating antioxidant properties of the 
diterpenes from seeds of Phalaris canariensis. Nutrition and Food Sciences 5(4):376-384. 
 Rosa Martha Perez-Gutierrez, Alethia Muñiz Ramírez (2015). Inhibitory Activities of Guaianolides from the Seeds 
of Byrsonima Crassifolia against Protein Glycation In Vitro. Medicinal chemistry. 2015, 5:5. 
 .http://dx.doi.org/10.4172/2161-0444.1000267 
 12. D. Madrigales-Ahuatzi, RM Perez-Gutierrez. (2016). Evaluation of anti-inflammatory activity of seeds of 
Phalaris canariensis. Drug Research. 66:23-27. Doi: http://dx.doi.org/10.1055/s-0035-1548764 
13.Rosa Martha Perez-Gutierrez (2016). Antidiabetic and antioxidant Properties, and α-amylase and α-glucosidase 
Inhibition Effects of Triterpene Saponins from Piper auritum. Food Sci. Biotechnol. 25(1): 229-239 (2016) DOI 
10.1007/s10068-016-0034-6 
14.Rosa Martha Perez-Gutierrez. (2016). Review of Cucurbita pepo (pumpkin) its phytochemistry and 
pharmacology. Medicinal Chemistry 6 (1):012-021, 2016, doi: 10.4172/2161-044.1000316 
15.Perez Gutierrez RM, Jahel Valdes Sauceda, Jose Maria Mota Flores, Blanca Elizabeth Lopes Silva. (2016). 
Protective effects of oleanane an ursane type triterpenoids from Origanum majorana against the formation of 
advanced glycation endproducts. Medicinal Chemistry 6 (2):095-114, doi: org/10.4172/2161-0444.1000333 
16.Perez Gutierrez RM. (2016). Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia. 
Food Science and Biotechnology 2016, 25(2), 561-566. 
17. Perez Gutierrez RM, Madrigales Ahuatzi D, Cruz Victoria T. (2016). Inhibition by seeds of Phalaris 
canariensis extracts of key enzymes linked to obesity. Altern Ther Health Med 2016; 22(1); 8-14. 
18. Rosa Martha Perez-Gutierrez, Alethia Muñiz Ramírez (2016). Hypoglycemic effects of sesquiterpenes lactones 
from Byrsonina crassifolia. Food Sci Biotechnol 25(4): 1135-1145. ISSN: 1226-7708 
19.Rosa Martha Perez-Gutierrez, Abraham H. Garcia Campoy, Alethia Muñiz Ramírez (2016) Properties of 
Flavonoids Isolated from the Bark of Eysenhardtia polystachya, and their Effect on Oxidative Stress in 
Streptozotocin-Induced Diabetes Mellitus in mice. Oxidative Med Cellular Longevity. Volume 2016 (2016), Article 
ID 9156510, 13 pages http://dx.doi.org/10.1155/2016/9156510 ISSN: 1942-0900 UK 
20. Rosa Martha Perez-Gutierrez, Rita Valadez Romero (2016) Effects of bixin in high-fat diet-fed-induced fatty 
liver in c57bl/6j mice. Asian Pacific J Tropical Biomedicine. 6(12):1015-1021. ISSN: 2222-1808, China 
21. Rosa Martha Pérez Gutiérrez (2017). Hypolipidemic and hypoglycemic activities of a oleanolic acid derivative 
from Malva parviflora on streptozotocin-induced diabetic mice. Archives of Pharmacal Research. 40(5), 550–562. 
DOI: 10.1007/s12272-016-0873-y 
 22. Rosa Martha Perez Gutierrez, Carlos Hoyo-Vadillo. (2017). Anti-inflammatory potential of Petiveria alliacea on 
activated RAW264.7 murine macrophages. Pharmacog Mag 13(50):S174-178 
23. Rosa Martha Perez Gutierrez, AbrahamH. Garcia Campoy. Jose Maria Mota Flores. (2017). Dihydrochalcones 
from the bark of Eysenhardtia polystachyai inhibit formationof advanced glycation and products at multiple stages in 
vitro studies. Journal of Pharmacy and Pharmacology. 1(3): 3-23. 
24. Karina Gutiérrez-García, Adriana Neira-González, Rosa Martha Pérez-Gutiérrez, Giovana Granados-Ramírez, 
Ramon Zarraga, Kazimierz Wrobel, Francisco Barona-Gómez, Luis B. Flores-Cotera. (2017). Phylogenomics and 
inhibitory activity upon the formation of Advanced Glycation End-Products of 2, 4-diacetylphloroglucinol-producing 
Pseudomonas endophytes from Piper auritum. J Nat Prod. 80(7): 1955-1963. Doi 10.1021/acs/natprod.6b00823 
25. Alethia Muniz . Abraham H. Garcia . Rosa M. Perez . Efren V. Garcıa . Daphne E. Gonzalez. (2017). In Vitro 
Inhibitory Activity of the End Products of Advanced Glycation of Acca sellowiana Fruit. Diabetes Ther. 
htps://doi.org/10.1007/s13300-017.0335-7 
 
Book: NANOSTRUCTURES FOR ORAL MEDICINE Edited By Ecaterina Andronescu and Alexandru Miltau 
Grumezescu. CHAPTER 2 A Novel Approach to the Oral Delivery of Bionanostructures for Systemic Disease 
Rosa Martha Perez Gutierrez, Juan Vicente Mendez Mendez, Israel Arzate Vazquez (2017). Elseviere 
 
http://dx.doi.org/10.4172/2161-0444.1000267
http://dx.doi.org/10.1055/s-0035-1548764
http://link.springer.com/journal/10068
http://www.ncbi.nlm.nih.gov/pubmed/?term=Perez%20Gutierrez%20RM%5BAuthor%5D&cauthor=true&cauthor_uid=26773316
http://www.ncbi.nlm.nih.gov/pubmed/?term=Madrigales%20Ahuatzi%20D%5BAuthor%5D&cauthor=true&cauthor_uid=26773316
http://www.ncbi.nlm.nih.gov/pubmed/?term=Cruz%20Victoria%20T%5BAuthor%5D&cauthor=true&cauthor_uid=26773316
http://www.ncbi.nlm.nih.gov/pubmed/26773316
http://dx.doi.org/10.1155/2016/9156510
https://link.springer.com/journal/12272
http://www.phcog.com/searchresult.asp?search=&author=Rosa+Martha+Perez+Gutierrez&journal=Y&but_search=Search&entries=10&pg=1&s=0
http://www.phcog.com/searchresult.asp?search=&author=Carlos+Hoyo%2DVadillo&journal=Y&but_search=Search&entries=10&pg=1&s=0
http://www.phcog.com/searchresult.asp?search=&author=Rosa+Martha+Perez+Gutierrez&journal=Y&but_search=Search&entries=10&pg=1&s=0