<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg1.png"><div class="c x1 y1 w2 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws2">HEMOST<span class="blank _0"></span>ASIA </div><div class="t m0 x3 h4 y3 ff2 fs1 fc0 sc0 ls0 ws0">INTRODUÇÃ<span class="blank _1"></span>O\ue601</div><div class="t m0 x3 h5 y4 ff3 fs1 fc0 sc0 ls0 ws0">Processo\ue601\ufb01siológico\ue601e\ue601dinâmico\ue601que\ue601visa\ue601manter\ue601o\ue601</div><div class="t m0 x3 h5 y5 ff3 fs1 fc0 sc0 ls0 ws0">sangue\ue601\ufb02uido\ue601no\ue601interior\ue601dos\ue601vasos,\ue601e\ue601impedindo\ue601que\ue601</div><div class="t m0 x3 h5 y6 ff3 fs1 fc0 sc0 ls0">ocorra\ue601uma\ue601hemorragia\ue601ou\ue601trombose\ue601e\ue601para\ue601que\ue601isso\ue601</div><div class="t m0 x3 h5 y7 ff3 fs1 fc0 sc0 ls0">aconteça\ue601é\ue601necessário\ue601que\ue601se\ue601construa\ue601um\ue601</div><div class="t m0 x3 h5 y8 ff3 fs1 fc0 sc0 ls0">tampão(trombo\ue601hemostático,\ue601que\ue601é\ue601o\ue601coagulo).\ue601</div><div class="t m0 x3 h5 y9 ff3 fs1 fc0 sc0 ls0">Nos\ue601mecanismos\ue601hemostáticos\ue601temos\ue601a\ue601hemostasia\ue601</div><div class="t m0 x3 h5 ya ff3 fs1 fc0 sc0 ls0">primária,\ue601secundária\ue601e\ue601terciária.\ue601</div><div class="t m0 x3 h4 yb ff2 fs1 fc0 sc0 ls0">Formação\ue601da\ue601Plaqueta\ue601\ue601</div><div class="t m0 x3 h5 yc ff3 fs1 fc0 sc0 ls0">Ocorre\ue601a\ue601partir\ue601da\ue601separação\ue601de\ue601pequenas\ue601partes\ue601de\ue601</div><div class="t m0 x3 h5 yd ff3 fs1 fc0 sc0 ls0">citoplasma\ue601das\ue601regiões\ue601periféricas\ue601dos\ue601</div><div class="t m0 x3 h5 ye ff3 fs1 fc0 sc0 ls0">megacariócitos,\ue601através\ue601de\ue601canais\ue601de\ue601demarcação\ue601</div><div class="t m0 x3 h5 yf ff3 fs1 fc0 sc0 ls0">plaquetária\ue601que\ue601formam\ue601um\ue601sistema\ue601canalicular\ue601</div><div class="t m0 x3 h5 y10 ff3 fs1 fc0 sc0 ls0">aberto,\ue601que\ue601se\ue601comunica\ue601com\ue601invaginações\ue601da\ue601</div><div class="t m0 x3 h5 y11 ff3 fs1 fc0 sc0 ls0">membrana\ue601plasmática.\ue601</div><div class="t m0 x3 h5 y12 ff3 fs1 fc0 sc0 ls0">-\ue601Ela\ue601vem\ue601da\ue601linhagem\ue601mieloide\ue601</div><div class="t m0 x3 h5 y13 ff3 fs1 fc0 sc0 ls0">-\ue601Vida\ue601média\ue601de\ue60110\ue601a\ue60114\ue601dias\ue601</div><div class="t m0 x3 h5 y14 ff3 fs1 fc1 sc0 ls0 ws0">Função:<span class="fc0">\ue601(hemostasia)\ue601garantir\ue601a\ue601coagulação\ue601do\ue601</span></div><div class="t m0 x3 h5 y15 ff3 fs1 fc0 sc0 ls0">sangue.\ue601</div><div class="t m0 x3 h5 y16 ff3 fs1 fc1 sc0 ls0 ws0">Como\ue601é\ue601formada:<span class="fc0">\ue601É\ue601formada\ue601pela\ue601ação\ue601da\ue601trombopoietina(TBO)\ue601em\ue601que\ue601é\ue601sintetizado\ue601nos\ue601</span></div><div class="t m0 x3 h5 y17 ff3 fs1 fc0 sc0 ls0">rins\ue601ou\ue601no\ue601fígado,\ue601onde\ue601esse\ue601hormônio\ue601vai\ue601atuar\ue601para\ue601a\ue601formação\ue601das\ue601plaquetas\ue601na\ue601medula\ue601</div><div class="t m0 x3 h5 y18 ff3 fs1 fc0 sc0 ls0">óssea.\ue601E\ue601sua\ue601destruição\ue601será\ue601no\ue601baço.\ue601</div><div class="t m0 x3 h4 y19 ff2 fs1 fc0 sc0 ls0">Estrutura\ue601Plaquetária\ue601</div><div class="t m0 x3 h5 y1a ff3 fs1 fc0 sc0 ls0">São\ue601fragmentos\ue601de\ue601megacariócitos(não\ue601são\ue601células)\ue601que,\ue601apesar\ue601de\ue601não\ue601possuírem\ue601núcleo,\ue601</div><div class="t m0 x3 h5 y1b ff3 fs1 fc0 sc0 ls0">apresentam\ue601características\ue601de\ue601células\ue601intactas.\ue601Existem\ue601as\ue601glicoproteínas,\ue601grânulo\ue601alfa\ue601e\ue601</div><div class="t m0 x3 h5 y1c ff3 fs1 fc0 sc0 ls0">grânulos\ue601densos\ue601e\ue601são\ue601eles:\ue601\ue601</div><div class="t m0 x3 h5 y1d ff3 fs1 fc1 sc0 ls0 ws0">Glicoproteínas\ue601</div><div class="t m0 x3 h5 y1e ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>GPIa:\ue601Reage\ue601com\ue601o\ue601colágeno(glicoproteína\ue601importante\ue601para\ue601a\ue601adesão\ue601plaquetária)\ue601</div><div class="t m0 x3 h5 y1f ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>GPIb:\ue601Atua\ue601na\ue601\ufb01xação\ue601da\ue601plaqueta\ue601ao\ue601endotélio\ue601vascular<span class="blank _0"></span>,\ue601se\ue601liga\ue601ao\ue601fator\ue601de\ue601von\ue601</div><div class="t m0 x4 h5 y20 ff3 fs1 fc0 sc0 ls0 ws0">Willbrand(proteína\ue601plasmática\ue601de\ue601alto\ue601peso\ue601molecular<span class="blank _0"></span>,\ue601produzida\ue601por\ue601células\ue601endoteliais\ue601e\ue601</div><div class="t m0 x4 h5 y21 ff3 fs1 fc0 sc0 ls0">megacariócitos,\ue601possui\ue601receptores\ue601para\ue601colágeno,\ue601plaquetas,\ue601e\ue601atividade\ue601ristocetina,\ue601</div><div class="t m0 x4 h5 y22 ff3 fs1 fc0 sc0 ls0">funciona\ue601na\ue601adesão\ue601de\ue601plaquetas\ue601ao\ue601colágeno\ue601e\ue601formação\ue601do\ue601tampão\ue601hemostático).\ue601</div><div class="t m0 x3 h5 y23 ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>GPIIb-\ue601IIIa:\ue601Atua\ue601na\ue601agregação\ue601plaquetária\ue601</div><div class="t m0 x3 h5 y24 ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>GPIV:\ue601Atua\ue601nas\ue601interações\ue601da\ue601superfície\ue601de\ue601contato\ue601\ue601</div><div class="t m0 x3 h5 y25 ff3 fs1 fc0 sc0 ls0 ws0">De\ufb01ciência\ue601dessas\ue601glicoproteínas\ue601nos\ue601causam\ue601doenças.\ue601Ex:\ue601com\ue601a\ue601falta\ue601de\ue601IB/IX\ue601temos\ue601a\ue601</div><div class="t m0 x3 h5 y26 ff3 fs1 fc0 sc0 ls0 ws0">síndrome\ue601de\ue601bernard-soulier<span class="blank _0"></span>,\ue601e\ue601na\ue601falta\ue601de\ue601IIB/IIIA\ue601temos\ue601trombastenia\ue601de\ue601glanzmann.\ue601</div><div class="t m0 x3 h5 y27 ff3 fs1 fc1 sc0 ls0 ws0">Grânulos-Alfa\ue601</div><div class="t m0 x3 h5 y28 ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>Fator\ue601de\ue601V<span class="blank _0"></span>onWillebrand\ue601</div><div class="t m0 x3 h5 y29 ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>Fibrogênio\ue601</div><div class="t m0 x3 h5 y2a ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>Fibronectina\ue601</div><div class="t m0 x3 h5 y2b ff3 fs1 fc1 sc0 ls0">Grânulos\ue601Densos\ue601</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg2.png"><div class="c x5 y2c w3 h6"><div class="t m0 x6 h5 y2d ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>ADP\ue601</div><div class="t m0 x6 h5 y2e ff3 fs1 fc0 sc0 ls0 ws1">\u2022<span class="blank"> </span>Cálcio\ue601</div><div class="t m0 x6 h4 y4 ff2 fs1 fc0 sc0 ls0 ws0">Coagulação<span class="ff3">:\ue601refere-se\ue601ao\ue601processo\ue601que\ue601leva\ue601à\ue601</span></div><div class="t m0 x6 h5 y5 ff3 fs1 fc0 sc0 ls0 ws0">formação\ue601\ufb01siológica\ue601que\ue601ocorre\ue601em\ue601resposta\ue601ao\ue601</div><div class="t m0 x6 h5 y6 ff3 fs1 fc0 sc0 ls0">dano\ue601vascular\ue601\ue601</div><div class="t m0 x6 h4 y7 ff2 fs1 fc0 sc0 ls0 ws0">Trombose<span class="ff3">:\ue601é\ue601o\ue601processo\ue601de\ue601coagulação\ue601patológica\ue601</span></div><div class="t m0 x6 h5 y8 ff3 fs1 fc0 sc0 ls0">com\ue601formação\ue601de\ue601um\ue601coágulo\ue601localizado,que\ue601pode\ue601</div><div class="t m0 x6 h5 y9 ff3 fs1 fc0 sc0 ls0">chegar\ue601a\ue601ocluir\ue601o\ue601vaso\ue601</div><div class="t m0 x6 h4 ya ff2 fs1 fc0 sc0 ls0 ws0">Fibrinólise<span class="ff3">:\ue601refere-se\ue601ao\ue601processo\ue601de\ue601dissolução\ue601</span></div><div class="t m0 x6 h5 yb ff3 fs1 fc0 sc0 ls0 ws0">do\ue601coágulo\ue601e\ue601atua\ue601sobre\ue601a\ue601\ufb01brina\ue601formada\ue601</div><div class="t m0 x6 h4 yd ff2 fs1 fc0 sc0 ls0 ws0">V<span class="blank _0"></span>asoconstrição:\ue601<span class="ff3">o\ue601dano\ue601físico\ue601ao\ue601vaso\ue601provoca\ue601uma\ue601resposta\ue601contrátil\ue601da\ue601musculatura\ue601lisa\ue601</span></div><div class="t m0 x6 h5 ye ff3 fs1 fc0 sc0 ls0 ws0">vascular<span class="blank _0"></span>,\ue601que\ue601diminui\ue601o\ue601calibre\ue601do\ue601vaso,\ue601podendo\ue601ocluir\ue601completamente\ue601e\ue601impedir\ue601a\ue601perda\ue601</div><div class="t m0 x6 h5 yf ff3 fs1 fc0 sc0 ls0">de\ue601sangue.\ue601</div><div class="t m0 x6 h4 y11 ff2 fs1 fc0 sc0 ls0 ws0">Hemostasia\ue601primaria\ue601ou\ue601fase\ue601celular:<span class="ff3">\ue601Quando\ue601o\ue601vaso\ue601sanguíneo\ue601sofre\ue601uma\ue601lesão\ue601ha\ue601uma\ue601</span></div><div class="t m0 x6 h5 y12 ff3 fs1 fc0 sc0 ls0">atração\ue601de\ue601plaquetas\ue601sendo\ue601apenas\ue601elas\ue601a\ue601fazerem\ue601o\ue601processo\ue601inicial\ue601que\ue601é\ue601formando\ue601um\ue601</div><div class="t m0 x6 h5 y13 ff3 fs1 fc0 sc0 ls0">tampão\ue601ou\ue601um\ue601trombo\ue601plaquetário(coagulação)\ue601naquela\ue601região.\ue601As\ue601plaquetas\ue601se\ue601ligam\ue601ao\ue601</div><div class="t m0 x6 h5 y14 ff3 fs1 fc0 sc0 ls0">colágeno\ue601do\ue601tecido\ue601e\ue601também\ue601se\ue601ligam\ue601a\ue601outras\ue601plaquetas.\ue601E\ue601teremos\ue601nessa\ue601hemostasia\ue601</div><div class="t m0 x6 h5 y15 ff3 fs1 fc0 sc0 ls0">primária\ue601três\ue601fases\ue601que\ue601são\ue601adesão,\ue601ativação\ue601e\ue601agregação.\ue601\ue601</div><div class="t m0 x6 h4 y17 ff2 fs1 fc1 sc0 ls0">Adesão\ue601Plaquetária\ue601\ue601</div><div class="t m0 x6 h5 y18 ff3 fs1 fc0 sc0 ls0">A\ue601hemostasia\ue601primária\ue601só\ue601acontece\ue601quando\ue601á\ue601um\ue601rompimento\ue601do\ue601vaso\ue601e\ue601a\ue601exposição\ue601da\ue601</div><div class="t m0 x6 h5 y19 ff3 fs1 fc0 sc0 ls0">camada\ue601sub-endotelial\ue601e\ue601ocorrendo\ue601então\ue601a\ue601saída\ue601de\ue601colágeno,\ue601sangue\ue601e\ue601fator\ue601de\ue601</div><div class="t m0 x6 h5 y1a ff3 fs1 fc0 sc0 ls0 ws0">V<span class="blank _0"></span>onWillebrand\ue601damos\ue601início\ue601a\ue601<span class="fc2">adesão\ue601plaquetária(coagulação)\ue601</span>que\ue601será\ue601a<span class="fc2">\ue601ligação\ue601do\ue601</span></div><div class="t m0 x6 h5 y1b ff3 fs1 fc2 sc0 ls0 ws0">colágeno\ue601com\ue601as\ue601plaquetas<span class="fc0">,\ue601então\ue601colágeno\ue601fará\ue601uma\ue601fraca\ue601ligação\ue601com\ue601a\ue601</span>GPIa<span class="fc0">\ue601com\ue601essa\ue601</span></div><div class="t m0 x6 h5 y1c ff3 fs1 fc0 sc0 ls0 ws0">fraca\ue601ligação\ue601será\ue601necessário\ue601ele\ue601se\ue601ligar\ue601com\ue601o\ue601<span class="fc3">GPIb</span>\ue601e\ue601ela\ue601se\ue601ligará\ue601ao\ue601fator\ue601de\ue601V<span class="blank _0"></span>on\ue601e\ue601o\ue601</div><div class="t m0 x6 h5 y1d ff3 fs1 fc0 sc0 ls0">mesmo\ue601se\ue601liga\ue601ao\ue601colágeno\ue601deixando\ue601uma\ue601forte\ue601ligação\ue601entre\ue601plaqueta\ue601e\ue601colágeno\ue601ocorrendo\ue601</div><div class="t m0 x6 h5 y1e ff3 fs1 fc0 sc0 ls0">a\ue601ativação\ue601dessa\ue601plaqueta.\ue601</div><div class="t m0 x6 h4 y20 ff2 fs1 fc1 sc0 ls0">Ativação\ue601Plaquetária\ue601</div><div class="t m0 x6 h5 y21 ff3 fs1 fc0 sc0 ls0 ws0">A\ue601plaqueta\ue601ao\ue601se\ue601ligar\ue601com\ue601o\ue601colágeno\ue601e\ue601ser\ue601ativada\ue601ela\ue601vai\ue601expor\ue601os\ue601<span class="fc2">grânulos\ue601alfa</span>\ue601que\ue601vão\ue601</div><div class="t m0 x6 h5 y22 ff3 fs1 fc0 sc0 ls0 ws0">liberar\ue601a<span class="fc2">\ue601\ufb01bronectina</span>\ue601e\ue601o\ue601<span class="fc2">\ufb01brogênio</span>\ue601e\ue601os\ue601<span class="fc2">grânulos\ue601densos</span>\ue601vão\ue601liberar\ue601o\ue601<span class="fc2">ADP</span>\ue601o\ue601mesmo\ue601ativa\ue601</div><div class="t m0 x6 h5 y23 ff3 fs1 fc0 sc0 ls0 ws0">a\ue601<span class="fc2">fosfolipase\ue601A2\ue601</span>e\ue601ativando\ue601também\ue601o\ue601<span class="fc2">tromboxano</span>\ue601<span class="fc2">A2</span>\ue601e\ue601o\ue601mesmo\ue601fazendo\ue601ativação\ue601de\ue601</div><div class="t m0 x6 h5 y24 ff3 fs1 fc0 sc0 ls0">outras\ue601plaquetas.\ue601</div><div class="t m0 x6 h4 y26 ff2 fs1 fc1 sc0 ls0">Agregação\ue601Plaquetária\ue601\ue601</div><div class="t m0 x6 h5 y27 ff3 fs1 fc0 sc0 ls0 ws0">Na\ue601ativação\ue601de\ue601mais\ue601plaquetas\ue601ocorre\ue601o\ue601processo\ue601da\ue601liberação\ue601de\ue601a\ue601<span class="fc2">GPIIb</span>-\ue601<span class="fc2">IIIa</span>\ue601da\ue601plaqueta\ue601</div><div class="t m0 x6 h5 y28 ff3 fs1 fc0 sc0 ls0 ws0">fazendo\ue601a\ue601<span class="fc2">união(agregação)</span>\ue601das\ue601plaquetas\ue601formando\ue601o\ue601<span class="fc2">trombo\ue601branco</span>\ue601dando\ue601o\ue601\ufb01m\ue601da\ue601</div><div class="t m0 x6 h5 y29 ff3 fs1 fc0 sc0 ls0">hemostasia\ue601primária.\ue601</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg3.png"><div class="c x5 y2f w3 h7"><div class="t m0 x6 h4 y30 ff2 fs1 fc0 sc0 ls0 ws3">Hemostasia\ue601secundaria\ue601ou\ue601<span class="blank"> </span>Fase\ue601Plasmática\ue601</div><div class="t m0 x6 h5 y31 ff3 fs1 fc2 sc0 ls0 ws0">Evita\ue601o\ue601ressangramento<span class="fc0">\ue601pela\ue601formação\ue601de\ue601uma\ue601rede\ue601de\ue601</span>\ufb01brina(coágulo)\ue601<span class="fc0">encarregada\ue601de\ue601</span></div><div class="t m0 x6 h5 y32 ff3 fs1 fc2 sc0 ls0 ws0">estabilizar\ue601o\ue601trombo(trombo\ue601branco)<span class="fc0">.\ue601É\ue601representada\ue601principalmente\ue601pela\ue601</span>cascata\ue601da\ue601</div><div class="t m0 x6 h5 y33 ff3 fs1 fc2 sc0 ls0 ws0">coagulação<span class="fc0">(formação\ue601da\ue601casquinha\ue601depois\ue601de\ue601algum\ue601corte)\ue601onde\ue601podemos\ue601ter\ue601duas\ue601vias:\ue601</span></div><div class="t m0 x6 h5 y34 ff3 fs1 fc0 sc0 ls0">intrínseca\ue601e\ue601extrínseca.\ue601</div><div class="t m0 x6 h4 y35 ff2 fs1 fc1 sc0 ls0">Via\ue601Extrínseca\ue601</div><div class="t m0 x6 h5 y36 ff3 fs1 fc0 sc0 ls0">Essa\ue601via\ue601ocorre\ue601quando\ue601ha\ue601uma\ue601lesão\ue601no\ue601vaso\ue601e\ue601a\ue601ativação\ue601do\ue601fator\ue601III\ue601e\ue601VII\ue601os\ue601mesmo\ue601se\ue601</div><div class="t m0 x6 h5 y37 ff3 fs1 fc0 sc0 ls0">unem\ue601e\ue601ativam\ue601o\ue601fator\ue601X.\ue601</div><div class="t m0 x6 h4 y38 ff2 fs1 fc1 sc0 ls0">Via\ue601Intrínseca\ue601\ue601</div><div class="t m0 x6 h5 y39 ff3 fs1 fc0 sc0 ls0">Essa\ue601via\ue601vai\ue601ocorrer\ue601quando\ue601as\ue601células\ue601sanguíneas\ue601começam\ue601a\ue601ter\ue601conexão\ue601com\ue601o\ue601colágeno\ue601</div><div class="t m0 x6 h5 y3a ff3 fs1 fc0 sc0 ls0">fazendo\ue601a\ue601ativação\ue601do\ue601fator\ue601XII\ue601ativando\ue601fator\ue601XI\ue601ativando\ue601IX\ue601e\ue601o\ue601mesmo\ue601ativando\ue601fator\ue601X\ue601</div><div class="t m0 x6 h5 y3b ff3 fs1 fc0 sc0 ls0">A\ue601junção\ue601do\ue601via\ue601intrínseca\ue601e\ue601extrínseca\ue601vão\ue601terminar\ue601em\ue601fator\ue601X\ue601nisso\ue601ambos\ue601transformam\ue601</div><div class="t m0 x6 h5 y3c ff3 fs1 fc2 sc0 ls0 ws0">protrombina<span class="fc0">\ue601em\ue601</span>trombina<span class="fc0">\ue601e\ue601ela\ue601atua\ue601transformando\ue601</span>\ufb01brinogênio<span class="fc0">\ue601em\ue601</span>\ufb01brina<span class="fc0">\ue601e\ue601essa\ue601\ufb01brina\ue601</span></div><div class="t m0 x6 h5 y3d ff3 fs1 fc0 sc0 ls0 ws0">fará\ue601uma\ue601rede\ue601fazendo\ue601o\ue601<span class="fc2">tampão</span>.\ue601Ou\ue601seja,\ue601essa\ue601fase\ue601\ue601da\ue601coagulação\ue601culmina\ue601com\ue601a<span class="fc2">\ue601geração\ue601</span></div><div class="t m0 x6 h5 y3e ff3 fs1 fc2 sc0 ls0 ws0">de\ue601trombina\ue601e\ue601a\ue601formação\ue601da\ue601\ufb01brina<span class="fc0">,\ue601proteína\ue601que\ue601ancora\ue601o\ue601tampão\ue601plaquetário.\ue601</span></div><div class="t m0 x6 h4 y3f ff2 fs1 fc0 sc0 ls0">Hemostasia\ue601Terciária\ue601</div><div class="t m0 x6 h4 y40 ff2 fs1 fc2 sc0 ls0 ws0">P<span class="ff3">rocesso\ue601enzimático\ue601de\ue601lise\ue601do\ue601coágulo<span class="fc0">.\ue601Assim\ue601que\ue601o\ue601trombo\ue601(coágulo\ue601de\ue601\ufb01brina)\ue601é\ue601formado\ue601</span></span></div><div class="t m0 x6 h5 y41 ff3 fs1 fc0 sc0 ls0 ws0">este\ue601já\ue601começa\ue601a\ue601ser\ue601dissolvido\ue601pelo\ue601sistema\ue601<span class="fc2">\ufb01brinolítico</span>\ue601endógeno(temos\ue601anticoagulantes\ue601</div><div class="t m0 x6 h5 y42 ff3 fs1 fc0 sc0 ls0">endógenos\ue601para\ue601estancar).\ue601Anticoagulante\ue601externo:\ue601heparina\ue601(medida\ue601pelo\ue601exame\ue601kPTT),\ue601</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg4.png"><div class="c x5 y2c w3 h6"><div class="t m0 x6 h5 y2d ff3 fs1 fc0 sc0 ls0 ws0">varfarina\ue601(medida\ue601pelo\ue601\ue601T<span class="blank _0"></span>AP)\ue601o\ue601nosso\ue601tecido\ue601começa\ue601a\ue601ativar\ue601a\ue601cascata\ue601através\ue601do\ue601fator\ue601\ue601</div><div class="t m0 x6 h5 y2e ff3 fs1 fc0 sc0 ls0 ws0">tecidual\ue601e\ue601o\ue601próprio\ue601tecido\ue601libera\ue601o\ue601TP<span class="blank _0"></span>A\ue601(ativador\ue601do\ue601plasminogênio\ue601tecidual)\ue601que\ue601converte\ue601</div><div class="t m0 x6 h5 y3 ff3 fs1 fc0 sc0 ls0">plasminogênio\ue601em\ue601plasmina.\ue601</div><div class="t m0 x6 h4 y5 ff2 fs1 fc1 sc0 ls0 ws0">Fibrinólise:<span class="ff3 fc0">\ue601\ue601Nesse\ue601\ue601processo\ue601\ue601é\ue601\ue601liberado\ue601\ue601vários\ue601\ue601fragmentos\ue601\ue601de\ue601\ue601\ufb01brina,\ue601\ue601os\ue601\ue601quais\ue601</span></div><div class="t m0 x6 h5 y6 ff3 fs1 fc0 sc0 ls0 ws0">chamamos\ue601de\ue601produtos\ue601de\ue601degradação\ue601da\ue601\ufb01brina\ue601(PDF),\ue601também\ue601conhecidos\ue601como\ue601\ue601</div><div class="t m0 x6 h5 y7 ff3 fs1 fc0 sc0 ls0">dímeros\ue601D\ue601(exame\ue601D-dímeros\ue601medem\ue601eles).\ue601A\ue601elevação\ue601do\ue601Dímero\ue601D\ue601pode\ue601ser\ue601causada\ue601por\ue601</div><div class="t m0 x6 h5 y8 ff3 fs1 fc0 sc0 ls0">trombose\ue601venosa\ue601profunda,\ue601coagulação\ue601intravascular\ue601disseminada,\ue601cirurgia,\ue601trauma\ue601ou\ue601</div><div class="t m0 x6 h5 y9 ff3 fs1 fc0 sc0 ls0">infecção\ue601recente\ue601.\ue601Também\ue601pode\ue601ser\ue601encontrada\ue601em\ue601pacientes\ue601com\ue601doença\ue601hepática,\ue601\ue601</div><div class="t m0 x6 h5 ya ff3 fs1 fc0 sc0 ls0 ws0">gestantes,\ue601eclampsia,\ue601cardiopatia\ue601e\ue601alguns\ue601tipos\ue601de\ue601câncer<span class="blank _0"></span>.\ue601Após\ue601cumprirem\ue601o\ue601papel\ue601de\ue601</div><div class="t m0 x6 h5 yb ff3 fs1 fc0 sc0 ls0">reparo\ue601a\ue601plasmina\ue601é\ue601degradada(para\ue601parar\ue601de\ue601ter\ue601ação)\ue601pela\ue601alfa\u20122\ue601antiplasmina\ue601enquanto\ue601\ue601o\ue601</div><div class="t m0 x6 h5 yc ff3 fs1 fc0 sc0 ls0 ws0">TP<span class="blank _0"></span>A\ue601sofre\ue601ação\ue601do\ue601inibidor\ue601do\ue601ativador\ue601do\ue601plasminogênio-1(P<span class="blank _0"></span>AI-1)\ue601liberado\ue601pelo\ue601</div><div class="t m0 x6 h5 yd ff3 fs1 fc0 sc0 ls0 ws0">endotélio.Se\ue601a\ue601plasmina\ue601não\ue601fosse\ue601degradada\ue601esta\ue601degradaria\ue601o\ue601\ufb01brinogênio\ue601solúvel\ue601</div><div class="t m0 x6 h5 ye ff3 fs1 fc0 sc0 ls0 ws0">circulante(\ufb01brinogenólise)\ue601prejudicando\ue601a\ue601coagulação.\ue601\ue601</div><div class="t m0 x6 h4 y10 ff2 fs1 fc0 sc0 ls0">Distúrbios\ue601da\ue601Hemostasia\ue601</div><div class="t m0 x6 h5 y11 ff3 fs1 fc0 sc0 ls0 ws0">Doenças\ue601Hemorrágicas(hemorragia):\ue601De\ufb01ciência\ue601da\ue601hemostasia\ue601primária\ue601ou\ue601secundária,\ue601</div><div class="t m0 x6 h5 y12 ff3 fs1 fc0 sc0 ls0">caracterizada\ue601por\ue601sangramentos\ue601\ue601</div><div class="t m0 x6 h5 y13 ff3 fs1 fc0 sc0 ls0">Doenças\ue601(trombose):\ue601caracteriza-se\ue601pela\ue601coagulação\ue601patológica,\ue601com\ue601formação\ue601de\ue601um\ue601</div><div class="t m0 x6 h5 y14 ff3 fs1 fc0 sc0 ls0">trombo\ue601localizado\ue601que\ue601pode\ue601evoluir\ue601e\ue601ocluir\ue601o\ue601vaso.\ue601</div><div class="t m0 x6 h4 y16 ff2 fs1 fc0 sc0 ls0">Distúrbios\ue601Plaquetários\ue601\ue601</div><div class="t m0 x6 h4 y17 ff2 fs1 fc1 sc0 ls0 ws0">Trombocitopenia:<span class="fc0">\ue601<span class="ff3">Redução\ue601na\ue601quantidade\ue601de\ue601plaquetas\ue601o\ue601que\ue601leva\ue601a\ue601uma\ue601propensão\ue601a\ue601</span></span></div><div class="t m0 x6 h5 y18 ff3 fs1 fc0 sc0 ls0">sangramentos.\ue601Encontrada\ue601em\ue601pacientes\ue601com\ue601dengue\ue601grave.\ue601\ue601</div><div class="t m0 x6 h4 y19 ff2 fs1 fc1 sc0 ls0 ws0">Trombocitose:<span class="ff3 fc0">\ue601Aumento\ue601da\ue601quantidade\ue601de\ue601plaquetas\ue601o\ue601que\ue601leva\ue601a\ue601propensão\ue601a\ue601formação\ue601de\ue601</span></div><div class="t m0 x6 h5 y1a ff3 fs1 fc0 sc0 ls0">coágulos(trombos)\ue601</div><div class="t m0 x6 h4 y1b ff2 fs1 fc1 sc0 ls0 ws0">Desordens\ue601da\ue601função\ue601plaquetária:<span class="ff3 fc0">\ue601hereditária\ue601e\ue601adquirida\ue601(doença\ue601de\ue601base)\ue601\ue601</span></div><div class="t m0 x6 h5 y1d ff3 fs1 fc0 sc0 ls0 ws0">A<span class="blank _0"></span>V<span class="blank _2"></span>ALIA<span class="blank _1"></span>ÇÃ<span class="blank _1"></span>O\ue601D<span class="blank _0"></span>A\ue601HEMOST<span class="blank _1"></span>ASIA/CO<span class="blank _1"></span>A<span class="blank _1"></span>GULA<span class="blank _1"></span>ÇÃ<span class="blank _1"></span>O\ue601</div><div class="t m0 x6 h5 y1e ff3 fs1 fc0 sc0 ls0">Indicações:\ue601</div><div class="t m0 x6 h5 y1f ff3 fs1 fc0 sc0 ls0 ws0">-\ue601A<span class="blank _1"></span>valiação\ue601de\ue601pacientes\ue601com\ue601manifestações\ue601clínicas\ue601ou\ue601história\ue601familiar\ue601para\ue601hemorragias\ue601</div><div class="t m0 x6 h5 y20 ff3 fs1 fc0 sc0 ls0">ou\ue601tromboses;\ue601</div><div class="t m0 x6 h5 y21 ff3 fs1 fc0 sc0 ls0">-\ue601Controle\ue601da\ue601terapia\ue601com\ue601anticoagulantes\ue601(varfarina/Marevan,\ue601heparina/\ue601Clexane,\ue601</div><div class="t m0 x6 h5 y22 ff3 fs1 fc0 sc0 ls0">rivaroxaban/\ue601Xarelto\ue601etc);\ue601</div><div class="t m0 x6 h5 y23 ff3 fs1 fc0 sc0 ls0 ws0">-\ue601A<span class="blank _1"></span>valiação\ue601de\ue601intervenções\ue601cirúrgicas\ue601(pré-operatório).\ue601</div><div class="t m0 x6 h4 y26 ff2 fs1 fc0 sc0 ls0">Diagnóstico\ue601</div><div class="t m0 x6 h5 y27 ff3 fs1 fc0 sc0 ls0">-\ue601Contagem\ue601de\ue601plaquetas\ue601</div><div class="t m0 x6 h5 y28 ff3 fs1 fc0 sc0 ls0 ws0">-\ue601T<span class="blank _1"></span>empo\ue601de\ue601sangramento\ue601</div><div class="t m0 x6 h5 y29 ff3 fs1 fc0 sc0 ls0">-\ue601Agregação\ue601plaquetária\ue601</div><div class="t m0 x6 h5 y2a ff3 fs1 fc0 sc0 ls0 ws0">-\ue601T<span class="blank _1"></span>empo\ue601de\ue601Protrombina\ue601</div><div class="t m0 x6 h5 y2b ff3 fs1 fc0 sc0 ls0 ws0">-\ue601T<span class="blank _1"></span>empo\ue601de\ue601Tromboplastina\ue601parcial\ue601ativado\ue601</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg5.png"><div class="c x5 y2c w3 h6"><div class="t m0 x6 h5 y2d ff3 fs1 fc0 sc0 ls0 ws0">-\ue601T<span class="blank _1"></span>empo\ue601de\ue601Trombina\ue601</div><div class="t m0 x6 h5 y2e ff3 fs1 fc0 sc0 ls0">-\ue601Dosagem\ue601de\ue601Fibrinogênio\ue601</div><div class="t m0 x6 h5 y3 ff3 fs1 fc0 sc0 ls0">-\ue601Dosagem\ue601de\ue601Fatores\ue601e\ue601Anticoagulantes\ue601circulantes\ue601</div><div class="t m0 x6 h5 y4 ff3 fs1 fc0 sc0 ls0">-\ue601Determinação\ue601de\ue601Antitrombina\ue601</div><div class="t m0 x6 h5 y5 ff3 fs1 fc0 sc0 ls0">-\ue601Dosagem\ue601de\ue601Proteínas\ue601C\ue601e\ue601S\ue601</div><div class="t m0 x6 h5 y6 ff3 fs1 fc0 sc0 ls0">-\ue601Dímero\ue601D\ue601</div><div class="t m0 x6 h4 y8 ff2 fs1 fc0 sc0 ls0">Coagulograma\ue601</div><div class="t m0 x6 h5 y9 ff3 fs1 fc2 sc0 ls0 ws0">Re\ufb02ete\ue601risco\ue601de\ue601sangramento\ue601e\ue601não\ue601de\ue601trombose<span class="fc0">,os\ue601testes\ue601de\ue601coagulação\ue601podem\ue601ser\ue601feitos\ue601</span></div><div class="t m0 x6 h5 ya ff3 fs1 fc0 sc0 ls0 ws0">no\ue601coagulograma\ue601,composto\ue601pelos\ue6014\ue601exames:\ue601T<span class="blank _0"></span>AP\ue601ou\ue601TP\ue601(tempo\ue601de\ue601protrombina,\ue601avalia\ue601</div><div class="t m0 x6 h5 yb ff3 fs1 fc0 sc0 ls0">quantos\ue601segundos\ue601demora\ue601para\ue601formar\ue601o\ue601coágulo,se\ue601der\ue601mais\ue601que\ue60112\ue601segundos\ue601suspeitamos\ue601</div><div class="t m0 x6 h5 yc ff3 fs1 fc0 sc0 ls0">de\ue601problema\ue601no\ue601fator\ue6017\ue601ou\ue601tecidual\ue601)\ue601que\ue601avalia\ue601a\ue601via\ue601extrínseca\ue601da\ue601coagulação,\ue601que\ue601é\ue601</div><div class="t m0 x6 h5 yd ff3 fs1 fc0 sc0 ls0 ws0">composta\ue601pelos\ue601fatores\ue601III\ue601(tromboplastina\ue601tissular),\ue601\ue601VII,\ue601X,\ue601V<span class="blank _2"></span>,\ue601II\ue601(protrombina),\ue601I\ue601</div><div class="t m0 x6 h5 ye ff3 fs1 fc0 sc0 ls0 ws0">(\ufb01brinogênio),\ue601\ufb01nalmente\ue601a\ue601\ufb01brina.\ue601Também\ue601tem\ue601o\ue601TTP\ue601A,\ue601TTP\ue601ou\ue601KPTT\ue601(tempo\ue601de\ue601</div><div class="t m0 x6 h5 yf ff3 fs1 fc0 sc0 ls0 ws0">tromboplastina\ue601parcial\ue601ativado,\ue601cerca\ue601de\ue60125\ue601segundos,\ue601se\ue601der\ue601maior\ue601signi\ufb01ca\ue601que\ue601falta\ue601os\ue601</div><div class="t m0 x6 h5 y10 ff3 fs1 fc0 sc0 ls0">fatores\ue6018,\ue6019,\ue60112\ue601,11,\ue601calitreina)\ue601que\ue601avalia\ue601a\ue601via\ue601intrínseca\ue601da\ue601coagulação\ue601que\ue601envolve\ue601vários\ue601</div><div class="t m0 x6 h5 y11 ff3 fs1 fc0 sc0 ls0 ws0">fatores\ue601de\ue601coagulação\ue601como\ue601os\ue601fatores\ue601XII,\ue601XI,\ue601IX,\ue601VIII,\ue601X,V<span class="blank _2"></span>,\ue601II\ue601(protrombina),\ue601I\ue601(\ufb01brinogênio)\ue601</div><div class="t m0 x6 h5 y12 ff3 fs1 fc0 sc0 ls0 ws0">e\ue601\ufb01nalmente\ue601a\ue601\ufb01brina.Paciente\ue601com\ue601T<span class="blank _0"></span>AP\ue601e\ue601KPTT\ue601alargado:\ue601problemas\ue601nos\ue601fatores\ue601a\ue601partir\ue601do\ue601</div><div class="t m0 x6 h5 y13 ff3 fs1 fc0 sc0 ls0 ws0">XTC:\ue601T<span class="blank _1"></span>empo\ue601de\ue601coagulação\ue601(não\ue601é\ue601muito\ue601usado)\ue601\ue601TS:\ue601tempo\ue601de\ue601sangramento\ue601(não\ue601é\ue601muito\ue601</div><div class="t m0 x6 h5 y14 ff3 fs1 fc0 sc0 ls0">usado).\ue601Nesse\ue601caso\ue601avalia-se\ue601como\ue601as\ue601plaquetas\ue601estão\ue601funcionando.\ue601</div><div class="t m0 x6 h4 y16 ff2 fs1 fc0 sc0 ls0">Plaquetograma\ue601</div><div class="t m0 x6 h5 y17 ff3 fs1 fc0 sc0 ls0">\ue601Análise\ue601das\ue601plaquetas\ue601\ue601</div><div class="t m0 x6 h5 y18 ff3 fs1 fc0 sc0 ls0">-\ue601Contagem\ue601de\ue601plaquetas\ue601\ue601</div><div class="t m0 x6 h5 y19 ff3 fs1 fc0 sc0 ls0">-\ue601Determinação\ue601do\ue601plaquetócrito(corresponde\ue601ao\ue601volume\ue601total\ue601de\ue601plaquetas\ue601num\ue601</div><div class="t m0 x6 h5 y1a ff3 fs1 fc0 sc0 ls0">determinado\ue601volume\ue601de\ue601sangue)\ue601</div><div class="t m0 x6 h5 y1b ff3 fs1 fc0 sc0 ls0">-\ue601Índices\ue601plaquetários:\ue601VPM\ue601e\ue601PDW\ue601</div><div class="t m0 x6 h5 y1c ff3 fs1 fc0 sc0 ls0">-\ue601Plaquetopenia\ue601e\ue601Plaquetocitose\ue601</div><div class="t m0 x6 h5 y1d ff3 fs1 fc0 sc0 ls0 ws0">-\ue601Dimero\ue601(Con\ufb01rma\ue601que\ue601houve\ue601geração\ue601de\ue601trombina\ue601e\ue601de\ue601plasmina)\ue601\ue601</div><div class="t m0 x6 h5 y1e ff3 fs1 fc0 sc0 ls0">-\ue601Fragmento\ue601da\ue601protrombina\ue601(F1+2)\ue601Marcador\ue601útil\ue601para\ue601a\ue601coagulação\ue601ativada\ue601(CID\ue601em\ue601baixo\ue601</div><div class="t m0 x6 h5 y1f ff3 fs1 fc0 sc0 ls0">grau\ue601e\ue601monitorar\ue601uso\ue601de\ue601anticoagulante\ue601oral).\ue601</div><div class="t m0 x6 h5 y20 ff3 fs1 fc1 sc0 ls0 ws0">V<span class="blank _0"></span>ariantes:\ue601\ue601</div><div class="t m0 x6 h5 y21 ff3 fs1 fc0 sc0 ls0">-Gravidez\ue601</div><div class="t m0 x6 h5 y22 ff3 fs1 fc0 sc0 ls0">-Altitude\ue601\ue601</div><div class="t m0 x6 h5 y23 ff3 fs1 fc0 sc0 ls0">-Idade\ue601\ue601</div><div class="t m0 x6 h5 y24 ff3 fs1 fc0 sc0 ls0">-Uso\ue601de\ue601fármacos\ue601</div><div class="t m0 x6 h4 y25 ff2 fs1 fc2 sc0 ls0">\ue601\ue601</div><div class="t m0 x6 h4 y26 ff2 fs1 fc0 sc0 ls0 ws0">Hemo\ufb01lia:\ue601<span class="ff3">Doença\ue601hemorrágica\ue601hereditária\ue601que\ue601</span></div><div class="t m0 x6 h5 y27 ff3 fs1 fc0 sc0 ls0">afeta\ue601a\ue601coagulação\ue601do\ue601sangue\ue601e\ue601pode\ue601causar\ue601</div><div class="t m0 x6 h5 y28 ff3 fs1 fc0 sc0 ls0">sangramentos\ue601prolongados\ue601e\ue601hematomas\ue601\ue601</div><div class="t m0 x6 h4 y29 ff3 fs1 fc0 sc0 ls0 ws0">Não\ue601possui\ue601cascata\ue601de\ue601coagulação.<span class="ff2">\ue601</span></div><div class="t m0 x6 h5 y2a ff3 fs1 fc0 sc0 ls0 ws0">Hemo\ufb01lia\ue601A:\ue601De\ufb01ciência\ue601no\ue601fato\ue601VIII\ue601</div><div class="t m0 x6 h5 y2b ff3 fs1 fc0 sc0 ls0 ws0">Hemo\ufb01lia\ue601B:\ue601De\ufb01ciência\ue601no\ue601fator\ue601IX\ue601</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/001846fd-749a-4d41-ad23-69137a946d3c/bg6.png"><div class="c x1 y2f w4 h8"><div class="t m0 x6 h5 y43 ff3 fs1 fc0 sc0 ls0 ws0">Hemo\ufb01lia\ue601C:\ue601De\ufb01ciência\ue601no\ue601fator\ue601XI\ue601</div><div class="t m0 x6 h5 y44 ff3 fs1 fc1 sc0 ls0 ws0">Manifestações\ue601clínicas<span class="fc0">:\ue601proporcional\ue601ao\ue601nível\ue601dos\ue601fatores\ue601de\ufb01cientes\ue601</span></div><div class="t m0 x6 h5 y45 ff3 fs1 fc0 sc0 ls0">Primeiras\ue601hemorragias\ue601\u2192\ue601Primeiro\ue601ou\ue601segundo\ue601ano\ue601de\ue601vida,\ue601sangramentos\ue601após\ue601pequenos\ue601</div><div class="t m0 x6 h5 y46 ff3 fs1 fc0 sc0 ls0">traumas.\ue601</div><div class="t m0 x6 h5 y47 ff3 fs1 fc0 sc0 ls0">Hemograma:\ue601normal\ue601</div><div class="t m0 x6 h5 y48 ff3 fs1 fc0 sc0 ls0 ws0">\u2022\ue601Após\ue601hemorragia\ue601intensa:\ue601neutro\ufb01lia\ue601</div><div class="t m0 x6 h5 y49 ff3 fs1 fc0 sc0 ls0">\u2022\ue601Hemorragia\ue601aguda\ue601ou\ue601crônica:\ue601plaquetose\ue601(sem\ue601relação\ue601à\ue601sangramento)\ue601</div><div class="t m0 x6 h5 y30 ff3 fs1 fc0 sc0 ls0">TS:\ue601Normal\ue601</div><div class="t m0 x6 h5 y31 ff3 fs1 fc0 sc0 ls0 ws0">TC:\ue601Normal\ue601ou\ue601aumentado\ue601</div><div class="t m0 x6 h5 y32 ff3 fs1 fc0 sc0 ls0">TP:\ue601Normal\ue601</div><div class="t m0 x6 h5 y33 ff3 fs1 fc0 sc0 ls0 ws0">TTPa:\ue601Aumentado\ue601</div><div class="t m0 x6 h5 y34 ff3 fs1 fc0 sc0 ls0">Dosagem\ue601de\ue601fator\ue601VIII\ue601(H.A)\ue601ou\ue601IX\ue601(H.B):\ue601Baixo\ue601</div><div class="t m0 x6 h4 y35 ff2 fs1 fc0 sc0 ls0 ws0">Hemo\ufb01lia\ue601C\ue601ou\ue601De\ufb01ciência\ue601do\ue601Fator\ue601XI\ue601</div><div class="t m0 x6 h5 y36 ff3 fs1 fc0 sc0 ls0">\u2022\ue601Herança\ue601Autossômica\ue601recessiva\ue601</div><div class="t m0 x6 h5 y37 ff3 fs1 fc0 sc0 ls0">\u2022\ue601Afeta\ue601ambos\ue601os\ue601sexos,\ue601mais\ue601comum\ue601em\ue601indivíduos\ue601de\ue601</div><div class="t m0 x6 h5 y4a ff3 fs1 fc0 sc0 ls0">origem\ue601judaica\ue601</div><div class="t m0 x6 h5 y38 ff3 fs1 fc0 sc0 ls0">\u2022\ue601Quadro\ue601clínico\ue601heterogêneo\ue601\u2192\ue601Hemorragias\ue601menos\ue601</div><div class="t m0 x6 h5 y39 ff3 fs1 fc0 sc0 ls0">frequentes\ue601(Traumas\ue601e\ue601processos\ue601cirúrgicos)\ue601</div><div class="t m0 x6 h4 y4b ff2 fs1 fc0 sc0 ls0 ws0">Trombo\ufb01lia\ue601</div><div class="t m0 x6 h5 y3b ff3 fs1 fc0 sc0 ls0">Caracteriza-se\ue601por\ue601uma\ue601tendência\ue601ao\ue601tromboembolismo,\ue601</div><div class="t m0 x6 h5 y3c ff3 fs1 fc0 sc0 ls0 ws0">ocorrendo\ue601principalmente\ue601pela\ue601de\ufb01ciência\ue601do\ue601sistema\ue601da\ue601anticoagulação\ue601natural\ue601e/ou\ue601pela\ue601</div><div class="t m0 x6 h5 y3d ff3 fs1 fc0 sc0 ls0">presença\ue601de\ue601mutações,\ue601com\ue601comprovação\ue601laboratorial.\ue601</div><div class="t m0 x6 h5 y3e ff3 fs1 fc0 sc0 ls0">\u2022\ue601Pode\ue601ser\ue601hereditária\ue601ou\ue601adquirida,\ue601primária\ue601ou\ue601secundária.\ue601</div><div class="t m0 x6 h5 y4c ff3 fs1 fc0 sc0 ls0">-\ue601Retorno\ue601venoso\ue601</div><div class="t m0 x6 h4 y3f ff2 fs1 fc0 sc0 ls0 ws0">Causas<span class="ff3">:\ue601Infecções\ue601virais,\ue601aterosclerose\ue601e\ue601leuce<span class="ff4 ws2">mia. <span class="ff5">!</span></span></span></div><div class="t m0 x6 h9 y4d ff4 fs1 fc0 sc0 ls0 ws2"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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