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journal of orthopaedic & sports physical therapy | volume 50 | number 2 | february 2020 | 83 [ research report ] A pproximately 1 in 4 patients who are 25 years of age or younger and return to high-risk sport (eg, soccer and team handball) after primary anterior cruciate ligament (ACL) reconstruction sustain a second ACL injury.28 Given that younger patients return to sport after ACL reconstruction in greater numbers than older patients, their greater exposure may explain the elevat- ed reinjury risk.3,4,17,27 There are conflicting find- ings regarding the relationship between passing specific return- to-sport tests and the risk of second ACL injury.10,15,19 Among youth athletes with a mean age of 17 years, there were no dif- ferences in strength and hop performance at the time of return-to-sport clearance between those who successfully resumed their preinjury sports participation and those who sustained a second ACL in- jury.15 Professional athletes who did not meet 6 discharge criteria before return- ing to sport had 4 times the risk of graft rupture compared to their peers who met the discharge criteria.19 In addition, pa- tients with more symmetrical quadriceps strength and who returned to sport at least 9 months after surgery had an 84% reduction in the rate of knee injuries.10 Key considerations when interpreting previous research on the relationship be- tween passing return-to-sport discharge criteria and second ACL injury include the heterogeneous populations (eg, profession- U OBJECTIVE: To investigate the association between sustaining a second anterior cruciate liga- ment (ACL) injury and (1) time to return to sport, (2) symmetrical muscle function, and (3) symmetrical quadriceps strength at the time of return to sport in young athletes after primary ACL reconstruction. U DESIGN: Prospective cohort study. U METHODS: Patient demographics and results from 5 tests of muscle function (2 strength tests and 3 hop tests) were extracted from a rehabilita- tion registry. A questionnaire was sent to athletes (15-30 years old) who were involved in knee-stren- uous sport before the injury and had undergone primary ACL reconstruction to determine time of return to knee-strenuous sport (preinjury Tegner Activity Scale score of 6 or greater). We used the Cox proportional hazard regression model to analyze time to event. U RESULTS: One hundred fifty-nine (32% of the initial sample) athletes (mean ± SD age, 21.5 ± 4.4 years; 50% female) were included. Athletes with a higher preinjury Tegner Activity Scale score had a higher rate of second ACL injury (hazard ratio = 2.1; 95% confidence interval: 1.2, 3.6; P24:1. . [Crossref] 4⒐ Roberto Arias, Jerry Monaco, Brad J. Schoenfeld. 202⒊ Return to Sport After an Anterior Cruciate Ligament Tear: Bridging the Gap Between Research and Practice. Strength & Conditioning Journal 45:6, 674-682. [Crossref] 50. Han Gao, Haichen Hu, Dandan Sheng, Luyi Sun, Jun Chen, Tianwu Chen, Shiyi Chen. 202⒊ Risk Factors for Ipsilateral Versus Contralateral Reinjury After ACL Reconstruction in Athletes: A Systematic Review and Meta-analysis. Orthopaedic Journal of Sports Medicine 11:⒓ . [Crossref] 51. Frank Diemer. 202⒊ Quo vadis, Nachbehandlung? – Nachbehandlungsschemata kritisch betrachtet. physiopraxis 21:11/12, 34-3⒎ [Crossref] 52. Gabriel Peixoto Leão Almeida, Thamyla Rocha Albano, Carlos Augusto Silva Rodrigues, Maria Larissa Azevedo Tavares, Pedro Olavo de Paula Lima. 202⒊ Combining return to sport, psychological readiness, body mass, hamstring strength symmetry, and hamstring/quadriceps ratio increases the risk of a second anterior cruciate ligament injury. Knee Surgery, Sports Traumatology, Arthroscopy 31:11, 5087-509⒌ [Crossref] 5⒊ Christin M. Zwolski, Mark V. Paterno, Robert A. Magnussen, Staci M. Thomas, Jacqueline D. Goodway, Brittany N. Hand, Catherine C. Quatman-Yates, Laura C. Schmitt. 202⒊ The Association of Physical Competence With Psychological Response Among Young Athletes at Time of Return to Sport After ACL Reconstruction. The American Journal of Sports Medicine 51:11, 2908-29⒘ [Crossref] 5⒋ Adam VanZile, Matthew Snyder, Daniel Jones, Thomas Gus Almonroeder. 202⒊ Athletes with a History of ACL Reconstruction Exhibit Greater Inter-Limb Asymmetry in Impact Forces During the First Landing of a Drop Vertical Jump Compared to the Second Landing. Journal of Electromyography and Kinesiology 100, 10280⒐ [Crossref] 5⒌ Bálint Zsidai, Ramana Piussi, Roland Thomeé, David Sundemo, Volker Musahl, Kristian Samuelsson, Eric Hamrin Senorski. 202⒊ Generalised joint hypermobility leads to increased odds of sustaining a second ACL injury within 12 months of return to sport after ACL reconstruction. British Journal of Sports Medicine 57:15, 972-97⒏ [Crossref] 5⒍ Eric Golberg, Adam Pinkoski, Lauren Beaupre, Hossein Rouhani. 202⒊ Monitoring External Workload With Wearable Technology After Anterior Cruciate Ligament Reconstruction: A Scoping Review. Orthopaedic Journal of Sports Medicine 11:⒏ . [Crossref] 5⒎ Madison D. Sroufe, Anna E. Sumpter, Xavier D. Thompson, Thomas E. Moran, Amelia S. Bruce Leicht, David R. Diduch, Stephen F. Brockmeier, Mark D. Miller, F. Winston Gwathmey, Brian C. Werner, Brian Pietrosimone, Joe M. Hart. 202⒊ Comparison of Patient-Reported Outcomes, Strength, and Functional Performance in Primary Versus Revision Anterior Cruciate Ligament Reconstruction. The American Journal of Sports Medicine 51:8, 2057-206⒊ [Crossref] 5⒏ Thomas J West, Andrea M Bruder, Kay M Crossley, Adam G Culvenor. 202⒊ Unilateral tests of lower-limb function as prognostic indicators of future knee-related outcomes following anterior cruciate ligament injury: a systematic review and meta-analysis of 13 150 adolescents and adults. British Journal of Sports Medicine 57:13, 855-86⒊ [Crossref] 5⒐ Sergio R. Piedade, Bruno P. Leite Arruda, Rodrigo A. de Vasconcelos, David A. Parker, Nicola Maffulli. 202⒊ Rehabilitation following surgical reconstruction for anterior cruciate ligament insufficiency: What has changed since the 1960s?—State of the art. Journal of ISAKOS 8:3, 153-162. [Crossref] 60. Tomoya Ishida, Mina Samukawa, Makoto Suzuki, Hisashi Matsumoto, Yu Ito, Miku Sakashita, Yoshimitsu Aoki, Masanori Yamanaka, Harukazu Tohyama. 202⒊ Improvements in asymmetry in knee flexion motion during landing are associated with the postoperative period and quadriceps strength after anterior cruciate ligament reconstruction. Research in Sports Medicine 31:3, 285-29⒌ [Crossref] 61. Rachel K. Straub, Christopher M. Powers. 202⒊ Is muscular strength a predictor for primary or secondary ACL injury? A scoping review of prospective studies. Physical Therapy in Sport 61, 91-101. [Crossref] 62. Tomoya Iwaasa, Tsuneari Takahashi, Keiji Tensho, Suguru Koyama, Katsushi Takeshita, Jun Takahashi. 202⒊ Suture Augmentation Does Not Change Biomechanical Properties and Histological Remodeling of Tendon Graft in Anterior Cruciate Ligament Reconstruction: A Study in a Porcine Model. Arthroscopy: The Journal of Arthroscopic & Related Surgery 39:4, 1014-102⒋ [Crossref] 6⒊ Rebecca Simonson, Ramana Piussi, Johan Högberg, Carl Senorski, Roland Thomeé, Kristian Samuelsson, Eric Hamrin Senorski. 202⒊ Effect of Quadriceps and Hamstring Strength Relative to Body Weight on Risk of a Second ACL J ou rn al o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® D ow nl oa de d fr om w w w .jo sp t.o rg a t o n O ct ob er 2 1, 2 02 4. F or p er so na l u se o nl y. N o ot he r us es w ith ou t p er m is si on . C op yr ig ht © 2 02 0 Jo ur na l o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® . 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Journal of Novel Physiotherapy and Physical Rehabilitation 10:1, 001-0⒑ [Crossref] 6⒐ Rebecca Simonson, Ramana Piussi, Eric Hamrin Senorski. Anterior Cruciate Ligament Injury: Non-operative Treatment and Post-operative Rehabilitation 1-⒘ [Crossref] 70. Anna Cronström, Eva Tengman, Charlotte K. Häger. 202⒊ Return to Sports: A Risky Business? A Systematic Review with Meta-Analysis of Risk Factors for Graft Rupture Following ACL Reconstruction. Sports Medicine 53:1, 91-1⒑ [Crossref] 71. Neeraj Baheti, StephenLaPlante, John Abt. Clinician Perspectives on Biomechanical Analysis and Return to Play: Pediatric Versus Adult 1-⒖ [Crossref] 72. Braidy Solie, Jill Monson, Christopher Larson. 202⒊ Graft-Specific Surgical and Rehabilitation Considerations for Anterior Cruciate Ligament Reconstruction with the Quadriceps Tendon Autograft. International Journal of Sports Physical Therapy 18:2. . 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Adolescent Patients Exhibit Significant Improvements in Strength and Functional Performance From 6 to 9 Months After ACL Reconstruction With Quadriceps Autograft. Arthroscopy, Sports Medicine, and Rehabilitation 3:3, e837-e84⒊ [Crossref] 1⒑ Bart Dingenen, Bart Billiet, Liesbet De Baets, Johan Bellemans, Jan Truijen, Alli Gokeler. 2021. Rehabilitation strategies of Flemish physical therapists before and after anterior cruciate ligament reconstruction: An online survey. Physical Therapy in Sport 49, 68-7⒍ [Crossref]1⒒ Anne Fältström, Joanna Kvist, Natalia F.N. Bittencourt, Luciana D. Mendonça, Martin Hägglund. 2021. Clinical Risk Profile for a Second Anterior Cruciate Ligament Injury in Female Soccer Players After Anterior Cruciate Ligament Reconstruction. The American Journal of Sports Medicine 49:6, 1421-1430. [Crossref] 1⒓ Anne Fältström, Martin Hägglund, Henrik Hedevik, Joanna Kvist. 2021. Poor Validity of Functional Performance Tests to Predict Knee Injury in Female Soccer Players With or Without Anterior Cruciate Ligament Reconstruction. The American Journal of Sports Medicine 49:6, 1441-1450. [Crossref] 1⒔ Manuel Köhne. 2021. Strategien bei Kreuzbandriss im Profisport - Versagen ist keine Option!. Orthopädie & Rheuma 24:1, 44-5⒊ [Crossref] 1⒕ Kate E. Webster, Julian A. Feller, Haydn J. Klemm. 2021. Second ACL Injury Rates in Younger Athletes Who Were Advised to Delay Return to Sport Until 12 Months After ACL Reconstruction. Orthopaedic Journal of Sports Medicine 9:2. . [Crossref] 1⒖ Aubrey Armento, Jay Albright, Alexia Gagliardi, Ariel Kiyomi Daoud, David Howell, Stephanie Mayer. 2021. Patient expectations and perceived social support related to return to sport after anterior cruciate ligament reconstruction in adolescent athletes. Physical Therapy in Sport 47, 72-7⒎ [Crossref] 1⒗ Sofi Sonesson, Annika Österberg, Håkan Gauffin, Clare L. Ardern, Joanna Kvist, Martin Hägglund. 2021. Low correlation between functional performance and patient reported outcome measures in individuals with non-surgically treated ACL injury. Physical Therapy in Sport 47, 185-192. [Crossref] 1⒘ Timothy Machan, Kody Krupps. 2021. The Neuroplastic Adaptation Trident Model: A Suggested Novel Framework for ACL Rehabilitation. International Journal of Sports Physical Therapy 16:⒊ . [Crossref] 1⒙ Casey Unverzagt, Evan Andreyo, Jeff Tompkins. 2021. ACL Return to Sport Testing: It’s Time to Step up Our Game. International Journal of Sports Physical Therapy 16:⒋ . [Crossref] 1⒚ Timothy R Wohl, Cody R Criss, Dustin R Grooms. 2021. Visual Perturbation to Enhance Return to Sport Rehabilitation after Anterior Cruciate Ligament Injury: A Clinical Commentary. International Journal of Sports Physical Therapy 16:2. . [Crossref] 1⒛ John R. Magill, Heather S. Myers, Trevor A. Lentz, Laura S. Pietrosimone, Thomas Risoli, Cindy L. Green, Emily K. Reinke, Michael R. Messer, Jonathan C. Riboh. 2021. Healthy Pediatric Athletes Have Significant Baseline Limb Asymmetries on Common Return-to-Sport Physical Performance Tests. Orthopaedic Journal of Sports Medicine 9:1. . [Crossref] 121. Yousif Eliya, Khaled Nawar, Benjamin B Rothrauff, Bryson P Lesniak, Volker Musahl, Darren de SA. 20⒛ Anatomical anterior cruciate ligament reconstruction (ACLR) results in fewer rates of atraumatic graft rupture, and higher rates of rotatory knee stability: a meta-analysis. Journal of ISAKOS 5:6, 359-370. [Crossref] 122. Ryuta INADA, Yuichi FUJII, Yuki INOUE, Ayaka TANI, Nozomi SATO, Kenta HANASHIRO, Yuuka YASUURA, Taku ARAAKE, Yuki MORIKAWA, Seiji DEMIZU. 20⒛ Comparison of Recovery Status Using Three Hop Tests One Year after Anterior Cruciate Ligament Reconstruction. Rigakuryoho Kagaku 35:6, 899-90⒊ [Crossref] J ou rn al o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® D ow nl oa de d fr om w w w .jo sp t.o rg a t o n O ct ob er 2 1, 2 02 4. F or p er so na l u se o nl y. N o ot he r us es w ith ou t p er m is si on . C op yr ig ht © 2 02 0 Jo ur na l o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® . A ll ri gh ts r es er ve d. https://doi.org/10.1016/j.asmr.2021.01.026 https://doi.org/10.1016/j.ptsp.2021.02.003 https://doi.org/10.1177/0363546521999109 https://doi.org/10.1177/03635465211002541 https://doi.org/10.1007/s15002-021-3199-1 https://doi.org/10.1177/2325967120985636 https://doi.org/10.1016/j.ptsp.2020.10.011 https://doi.org/10.1016/j.ptsp.2020.12.006 https://doi.org/10.26603/001c.23679 https://doi.org/10.26603/001c.25463 https://doi.org/10.26603/001c.21251 https://doi.org/10.1177/2325967120982309 https://doi.org/10.1136/jisakos-2020-000476 https://doi.org/10.1589/rika.35.899 Feb2020-RR-Beischer 50-07 Corrigendum“Have you, since your primary ACL re- construction, reached any of these lev- els of physical activity?” (yes/no) (TABLE 1). If the athlete answered “yes,” then he or she was asked, “Please specify when [month/year] you returned to at least level 6” (on the Tegner Activity Scale). We calculated the variable “time (months) of return to knee-strenuous sport” based on the questionnaire responses. We pilot tested the questionnaire with 10 patients with ACL injury (not included in the study) to improve face validity, and made no changes to the questionnaire. The online questionnaire was sent to 494 athletes who had fulfilled the inclu- sion criteria. The athletes who did not respond to the questionnaire received up to 2 reminders by text message within a week of first contact, followed by up to 2 reminders by e-mail. Finally, nonre- sponders were contacted by telephone. A total of 344 athletes responded. Achieving Symmetrical Muscle Func- tion Data from strength and hop tests from the follow-up closest to return to sport were extracted from the Project ACL database (TABLE 2). All athletes completed a test battery of 2 strength tests (either isokinetic or isometric knee extension and knee flex- ion, reflecting quadriceps and hamstring strength) and 3 single-leg hop tests. Be- fore completing the test battery, athletes had to fulfill the following criteria: mini- mal knee pain, minimal knee effusion, performed single-leg exercise without TABLE 1 Project-Specific Questionnaire Regarding Return to Sport 1. Have you, since your primary anterior cruciate ligament reconstruction, reached any of these levels of physical activity? (yes/no) If yes: 1a. Please specify when you returned to at least level 6 (month/year) Tegner Activity Scale Levels 6 to 10 and Corresponding Sports Level 6: baseball, hurdling, orienteering, snowboarding Level 7: badminton, high jump, tennis, downhill skiing, volleyball Level 8: basketball, handball, floorball, long jump Level 9: football, ice hockey, mogul skiing Level 10: football: national or international level, American football, wrestling, figure skating TABLE 2 Follow-ups and Number of Athletes Included in the Analysis, With Respect to Time to RTS Abbreviation: RTS, return to sport. Time to RTS, mo Month Data Were Extracted Included Athletes (n = 159), n (%) 7-11 8 101 (63.5) 12-17 12 40 (25.2) 18-23 18 13 (8.2) 24-35 24 4 (2.5) ≥36 36 1 (0.6) J ou rn al o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® D ow nl oa de d fr om w w w .jo sp t.o rg a t o n O ct ob er 2 1, 2 02 4. F or p er so na l u se o nl y. N o ot he r us es w ith ou t p er m is si on . C op yr ig ht © 2 02 0 Jo ur na l o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® . A ll ri gh ts r es er ve d. journal of orthopaedic & sports physical therapy | volume 50 | number 2 | february 2020 | 85 perceiving new or increased symptoms, and trained single-leg maximal hop tests with their responsible physical thera- pist outside the testing environment for Project ACL data collection. At the time of follow-up, the test leader assessed the patient’s health status to ensure that he or she was well prepared to perform the tests. The test procedure, including a warm- up procedure, familiarization, and maxi- mum repetitions in both strength and hop tests, has been described in detail in previous studies (TABLE 3).4,13 The results from the strength and hop tests were expressed as the limb symmetry index (LSI), defined as the ratio between the injured side and the uninjured side and expressed as a percentage. Symmetrical muscle function was defined as achieving an LSI of 90% or greater in all 5 tests of muscle function. The LSI for the strength tests was calculated from isometric tests of quad- riceps strength and hamstring strength using the F200 DMS-EVE (David Health Solutions Ltd, Helsinki, Finland) and from isokinetic concentric strength tests of the quadriceps and hamstrings using the Biodex System 4 (Biodex Medical Systems, Shirley, NY). In our study, the isometric tests contributed to 9% of the total muscle strength LSI data. Isomet- ric and isokinetic strength tests are highly reliable (intraclass correlation coefficient = 0.91-0.99).1,7,21,23 After the strength testing, the partici- pants performed 3 single-leg hop tests in the following order: vertical hop, hop for distance, and side hop.4,13 High test- retest reliability for the 3 different tests in the battery of hop tests has been re- ported (intraclass correlation coefficient = 0.93-0.97).11 Patient Characteristics We extracted age at primary ACL recon- struction, sex, anthropometric data, and preinjury Tegner Activity Scale score from the Project ACL database. Outcome The primary outcome was sustaining a subsequent ACL injury (yes/no). The injuries were confirmed by the treating physical therapist or orthopaedic surgeon. There were no specific criteria to verify the ACL injury. No maximum time of follow- up was determined. Data regarding sub- sequent ACL injury were extracted from the Project ACL database, comprising the number of ACL injuries, date of the subse- quent ACL injury, and side of injury. Statistical Analysis Statistical analysis was performed using the SAS statistical analysis system (SAS/ STAT Version 14.2; SAS Institute Inc, Cary, NC). Descriptive statistics for pa- tient demographics and outcomes were reported with count and proportion for categorical variables. Continuous vari- ables were reported with mean, SD, me- dian, and range. For comparisons between athletes with complete data and those lost to follow-up, we used the Fisher exact test (lowest 1-sided P value multiplied by 2) for dichotomous variables, the Man- tel-Haenszel chi-square exact test for ordered categorical variables, and the Mann-Whitney U test for continuous variables. We used a Cox proportional hazard regression model for the analyses of time to second ACL injury, with time to return to sport, symmetrical muscle function, symmetrical quadriceps strength, and demographics as independent variables. Time to return to sport was dichotomized into less than 9 months and 9 months or greater.10 Time 0 was defined as the first month of participation in sports equal to knee-strenuous sport (ie, a Tegner Ac- tivity Scale score of 6 or greater). Sym- metrical muscle function was defined as achieving an LSI of 90% or greater in all 5 tests of muscle function. Symmetri- cal quadriceps strength was defined as achieving an LSI of 90% or greater in quadriceps strength. Hazard ratios (HRs) were calculated for descriptive purposes. Data were checked for nonpropor- tionality using the supremum test for proportional hazards assumption, and by introducing a time-dependent co- variate (the interaction between the TABLE 3 Tests of Muscle Functiona Abbreviation: RM, repetition maximum. aModified under a Creative Commons CC-BY-NC license (https://creativecommons.org/licenses/by-nc/ 4.0/) with permission from Beischer S, Hamrin Senorski E, Thomeé C, Samuelsson K, Thomeé R. Knee strength, hop performance and self-efficacy at 4 months are associated with symmetrical knee muscle function in young athletes 1 year after an anterior cruciate ligament reconstruction. BMJ Open Sport Exerc Med. 2019;5:e000504. https://doi.org/10.1136/bmjsem-2018-000504 bMeasured with the F200 DMS-EVE (David Health Solutions Ltd, Helsinki, Finland). cMeasured with the Biodex System 4 (Biodex Medical Systems, Shirley, NY) at 90°/s. dMeasured with the F300 DMS-EVE (David Health Solutions Ltd). eMeasured with MUSCLELAB (Ergotest Innovation AS, Porsgrunn, Norway). fAs many hops as possible in 30 seconds over 2 lines 40 cm apart. Knee Angle, deg Practice Trials, n (% 1-RM) Maximum Repetitions, n Rest Between Repetitions, s Knee extension 3-5 40 Isometricb 60 3 (70, 80, 90)Isokineticc 0-90 1-2 (90) Knee flexion 3-5 40 Isometricd 30 3 (70, 80, 90) Isokineticc 0-90 1-2 (90) Single-leg vertical hope ... 2 3 20-30 Single-leg hop for distance ... 2 3 20-30 Single-leg side hopf ... 10 1 180 J ou rn al o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® D ow nl oa de d fr om w w w .jo sp t.o rg a t o n O ct ob er 2 1, 2 02 4. F or p er so na l u se o nl y. N o ot he r us es w ith ou t p er m is si on . C op yr ig ht © 2 02 0 Jo ur na l o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® . A ll ri gh ts r es er ve d. https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ https://doi.org/10.1136/bmjsem-2018-000504 86 | february 2020 | volume 50 | number 2 | journal of orthopaedic & sports physical therapy [ research report ] independent variable of time to return to sport and the time variable of time from return to sport). To compare mod- els, generalized R2 was calculated for the univariable analysis. We planned a multiple survival analysis with stepwise Cox proportional hazard regression. However, a model based on fewer than 20 events would have been overfitted with unreliable results5 and was not performed. Sensitivity analyses were performed to check for influential outliers by excluding 10% of the variables with the most influ- ence on significant factors. In addition, we analyzed the association between time to return to sport and subsequent ACL injury for all eligible athletes, regardless of whether they had performed the mus- cle function tests. Significance tests were conducted at the 5% level. RESULTS O ne hundred fifty-nine (32%) athletes completed the muscle function tests. The main reason for exclusion from further analyses was that the athlete had not performed tests of muscle function close to the time of re- turn to sport (n = 105) (FIGURE 1). There were no differences in sex, age, preinjury level of physical activity, and anthropometrics between athletes with complete data (n = 159) and athletes with missing data from the muscle function tests or the study-specific questionnaire (n = 335). The athletes with complete data had a shorter time from injury to ACL reconstruction compared with the excluded individuals, by an average of 2 months (P = .007). The athletes (n = 159) had an average age of 21.5 ± 4.4 years at their primary ACL reconstruction, and 50% were fe- male. The median time to return to sport for all included athletes was 11.0 months (range, 7.5-37.9 months). One hundred one athletes (64%) returned to knee- strenuous sport between 7 and 11 months after ACL reconstruction (TABLE 2). The median follow-up time was 15.5 months (range, 0.4-46.5 months) after return to sport, and the time between return to sport and athletes answering the study- specific questionnaire ranged from 2 days to 5 years, with an average of 1.3 years. Athletes performed the tests of muscle function 65 ± 47 days before return to sport. The average LSI for each of the 5 muscle function tests varied between 89% and 99%. Twenty-four percent (n = 39) of the athletes achieved symmetrical muscle function across the battery of tests before returning to knee-strenuous sport. Eighteen (11%) athletes sustained a new ACL injury that was registered in Project ACL: 10 graft ruptures and 8 contralateral ACL ruptures (TABLE 4) oc- curred between 9 and 36 months after ACL reconstruction (median, 19 months). Athletes who sustained a new ACL injury returned to knee-strenuous sport, on av- erage, 10.1 ± 3.3 months (range, 7.6-19.4 months) after ACL reconstruction, com- pared with 12.7 ± 4.8 months (range, 7.5- 37.9 months) for athletes with no new ACL injury (TABLE 5). Ten of the 33 athletes who returned to knee-strenuous sport ear- lier than 9 months after reconstruction sustained a new ACL injury. Twelve (67%) of the second ACL injuries occurred in athletes who returned to knee-strenuous sport between 8 and 9 months after ACL reconstruction. Athletes who returned to knee-stren- uous sport at 9 months or later after sur- gery had a lower rate of new ACL injury compared with those who returned ear- lier than 9 months after ACL reconstruc- tion (HR = 0.15; 95% confidence interval [CI]: 0.06, 0.39; PACL injury in athletes who had returned to knee-stren- uous sport earlier than 9 months after surgery. Even though some of the included athletes returned to sports that were less demanding of knee function than in other studies,6,10 our results mirror the findings of previous research. Achieving Symmetrical Muscle Function We did not find an association between achieving symmetrical muscle function and sustaining a second ACL injury. However, only 5 (28%) of the athletes who sustained a second ACL injury, and 33 (23%) of the athletes who did not, regained symmetrical muscle function close to return to sport. The fact that few athletes had symmetrical muscle func- tion, in combination with a relatively limited population (n = 159), may explain TABLE 4 Baseline Demographics, Stratified by Athletes With and Without Subsequent ACL Injurya Abbreviations: ACL, anterior cruciate ligament; NA, not applicable; TAS, Tegner Activity Scale. aValues are mean ± SD or mean ± SD and median (range) unless otherwise indicated. For comparison between groups, Fisher’s exact test (lowest 1-sided P value multiplied by 2) was used for dichotomous variables, the Mantel-Haenszel chi-square test was used for ordered categorical variables, and the Mann-Whitney U test was used for continuous variables. Subsequent ACL Injury (n = 18) No Subsequent ACL Injury (n = 141) P Value Patient sex, n (%) .47 Female 11 (61) 59 (49) Height, cm 171.2 ± 8.3 174.7 ± 9.5 .13 Weight, kg 67.2 ± 8.5 71.2 ± 12.5 .21 Preinjury TAS score, n (%) .029 6 0 (0.0) 6 (4.3) 7 2 (11.1) 18 (12.8) 8 3 (16.7) 43 (30.5) 9 5 (27.8) 51 (36.2) 10 8 (44.4) 23 (16.3) Graft choice, n (%) .099 Hamstring 13 (72.2) 120 (87.0) Patella 4 (22.2) 17 (12.3) Quadriceps 1 (5.6) 0 (0) Allograft 0 (0) 1 (0.7) Age at index ACL reconstruction, y 20.3 ± 3.4 21.7 ± 4.5 .21 Time from ACL injury to reconstruction, mo 4.3 ± 4.8 2.8 (0.1-20.8) 6.4 ± 8.1 3.9 (0.2-58.7) .041 Time of follow-up, mo 11.1 ± 10.0 7.6 (0.4-28.4) 19.4 ± 11.1 16.5 (2.5-46.5) NA TABLE 5 Postoperative Outcome in Patients With and Without a Subsequent ACL Injurya Abbreviations: ACL, anterior cruciate ligament; LSI, limb symmetry index; RTS, return to sport. aValues are mean ± SD and median (range) unless otherwise indicated. bAll 5 tests of muscle function: LSI of 90% or greater. Subsequent ACL Injury (n = 18) No Subsequent ACL Injury (n = 141) Time to RTS, mo 10.1 ± 3.3 8.6 (7.6-19.4) 12.7 ± 4.8 11.0 (7.5-37.9) Symmetrical muscle functionb closest to RTS, n (%) 5 (27.8) 33 (23.4) Quadriceps LSI, % 92.3 ± 12.1 93.2 (56.9-112.0) 95.7 ± 9.4 96.5 (74.6-121.3) J ou rn al o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® D ow nl oa de d fr om w w w .jo sp t.o rg a t o n O ct ob er 2 1, 2 02 4. F or p er so na l u se o nl y. N o ot he r us es w ith ou t p er m is si on . C op yr ig ht © 2 02 0 Jo ur na l o f O rt ho pa ed ic & S po rt s Ph ys ic al T he ra py ® . A ll ri gh ts r es er ve d. http://www.jospt.org 88 | february 2020 | volume 50 | number 2 | journal of orthopaedic & sports physical therapy [ research report ] why there was no association between new ACL injury and muscle function. Our results contradict previous re- search that has supported a relationship between muscle function and new knee injury.10,19 The discrepancies in results might be explained by different athlete populations (we studied a mixed group of professional and nonprofessional ath- letes; Kyritsis et al19 only included male professional athletes) and by all athletes in our study having achieved an average LSI of 90% or greater (athletes in the study by Grindem et al10 had an aver- age LSI of between 75% and 84%). The higher LSI in our study might have been protective against a second ACL injury, and was partly explained by our criteria for patients to participate in completing the muscle function tests. Approximately 1 in every 10 athletes in our study sustained a new ACL injury, which is lower than the proportion found in other reports.6,26,28 Our results might be explained by the fact that the athletes were repeatedly assessed with tests of muscle function and patient-reported outcomes. Structured and progressive preoperative and postoperative rehabili- tation, combined with clear goal setting and detailed patient information, may improve rehabilitation outcomes.9 Patient Demographics Higher preinjury physical activity level was associated with a higher rate of sub- sequent ACL injury. Our results support previous research10 in which patients returning to level 1 sport (eg, soccer and team handball) had a 4-fold increase in the risk of a subsequent knee injury com- pared with those who did not participate in level 1 sport (29.7% versus 6.9%). In the present study, the rate of second ACL injury was approximately 25% in athletes with a preinjury Tegner Activity Scale score of 10, which is in accordance with previous studies.2,8,16,22,26,28 Younger age has been reported as a risk factor for subsequent ACL injury.10,20 We did not find an association between second ACL injury and patient demo- graphics. This may be because we studied a young group of patients, and the rate of new ACL injuries was low. Limitations Only one third of the 494 eligible athletes responded to the study-specific question- naire and had attended a follow-up of muscle function testing close to the time of return to sport. New ACL injuries were diagnosed clinically by the responsible physical therapist or orthopaedic surgeon. Because magnetic resonance imaging veri- fication of injury was not mandatory, some ACL injuries might have been missed. The mean follow-up time of 15.5 months to re- TABLE 6 HRs Associated With a Subsequent ACL Injury (n = 159) Value Event Rate HR of Subsequent Injurya P Value Generalized R2 Patient sex 0.69 (0.27, 1.77) .44 0.004 Female 8.6 Male 6.0 Height (cm), HR per 10 units 0.96 (0.91, 1.01) .14 0.014 150-defined as a Tegner Activity Scale score of level 6 or above, and none of the eligible athletes sustained a second ACL injury prior to return to sport, which eliminates the risk of immortal time bias. Therefore, the use of the Tegner Activity Scale (level 6 or above) may be an appropriate proxy for the risk exposure for ACL injury. A comparison analysis of demograph- ics between athletes with complete data and those lost to follow-up revealed no significant differences, except for the time between ACL injury and ACL recon- struction. There is no reason to believe that this influenced the results. However, we cannot rule out bias in the results due to unmeasured factors. We used 2 different modes of strength testing (isometric and isokinetic). As previous studies have demonstrated a moderate to high correlation between isometric and isokinetic tests of knee strength,14,18 we suggest that using results from 2 different tests had no or only mi- nor influence on the conclusions drawn. We did not account for other factors that might further explain the risk of second ACL injury, such as differences in reha- bilitation protocols, surgical techniques of ACL reconstruction, the treatment of concomitant injuries, contextual and so- cial factors, and psychological factors. CONCLUSION R eturning to knee-strenuous sport before 9 months after ACL re- construction was associated with a 7-fold increased rate of sustaining a sec- ond ACL injury. Achieving symmetrical muscle function or quadriceps strength was not associated with new ACL injury in young athletes. U KEY POINTS FINDINGS: The rate of a subsequent an- terior cruciate ligament (ACL) injury was approximately 7 times higher in athletes who returned to knee-strenuous sport earlier than 9 months after ACL reconstruction compared with athletes who returned to sport at or later than 9 months. There were no associations be- tween sustaining a subsequent ACL in- jury and achieving symmetrical muscle function or quadriceps strength. IMPLICATIONS: Clinicians should inform young athletes who undergo ACL recon- struction that delaying return to knee- strenuous sport until at least 9 months after ACL reconstruction confers a re- duction in subsequent ACL injury rate. CAUTION: This study only included 18 ath- letes who sustained a subsequent ACL injury, which limited the opportunities for in-depth analyses and assessment of multiple risk factors. The nonsignificant association between achieving symmet- rical muscle function and a subsequent ACL injury may be attributed to low sta- tistical power and to the fact that 68% of the athletes had missing data from the muscle function tests. ACKNOWLEDGMENTS: The authors thank bio statisticians Bengt Bengtsson and Nils- Gunnar Pehrsson from Statistiska Konsult- gruppen for help with statistical analyses. STUDY DETAILS AUTHOR CONTRIBUTIONS: All authors contributed to project planning. Drs Beischer, Hamrin Senorski, and Thomeé and Ms Gustavsson and Mr Thomeé acquired the data. Drs Beischer, Hamrin Senorski, and Thomeé and Ms Gustavs- son interpreted data. Dr Beischer and Ms Gustavsson drafted the manuscript. All authors critically revised the manu- script and approved the final version. 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Time From RTS to Event/End of Study, mo 0 6 12 18 24 30 36 42 48 Neeter C, Thomeé P, et al. 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https://www.jospt.org/action/showLinks?pmid=9291696&citationId=p_5 https://www.jospt.org/action/showLinks?pmid=24451111&crossref=10.1177%2F0363546513517540&citationId=p_26 https://www.jospt.org/action/showLinks?pmid=24451111&crossref=10.1177%2F0363546513517540&citationId=p_26 https://www.jospt.org/action/showLinks?pmid=25899429&crossref=10.1177%2F0363546515578836&citationId=p_16 journal of orthopaedic & sports physical therapy | volume 50 | number 2 | february 2020 | c1 [ research report ] APPENDIX HRS OF EACH OF THE INDEPENDENT VARIABLES FOR THE SENSITIVITY ANALYSES (N = 264) Value Event Ratea n HR of Subsequent Injuryb P Value Generalized R2 Patient sex 0.61 (0.24, 1.53) .29 0.004 Female 5.6 140 Male 3.4 124 Height (cm), HR per 10 units 0.95 (0.91, 1.00) .043 0.014 150-Reconstruction: A Case Report. 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HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery 20:3, 431-43⒍ [Crossref] ⒘ Mathilde Lundgaard‐Nielsen, Robert Bennike Herzog, Susan Warming, Martin Wyman Rathcke, Stig Peter Magnusson, Michael Rindom Krogsgaard. 202⒋ Good physical function but reduced quality of life in children 3 years after ACL reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy 32:7, 1725-173⒊ [Crossref] ⒙ Stephan G. Bodkin. 202⒋ Time to Reflect on Return to Sport Timing Following ACL Reconstruction. Sports Medicine 54:7, 1749-175⒋ [Crossref] ⒚ Thomas R. Hays, Michael S. Barnum, Bruce A. Levy. 202⒋ Editorial Commentary: Combined Anterior Cruciate Ligament/Medial Collateral Ligament Injuries: Surgeons Should Have a Low Threshold to Operate on the Medial Collateral Ligament. Arthroscopy: The Journal of Arthroscopic & Related Surgery 89. . [Crossref] ⒛ Nasim Eshraghi, Peyman Mirghaderi, Reza Omid, Mohamad Sajadi, Amirreza Pashapour‐Yeganeh, S. M. 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A ll ri gh ts r es er ve d. https://doi.org/10.1177/15563316241247202 https://doi.org/10.1002/ksa.12211 https://doi.org/10.1007/s40279-024-02017-0 https://doi.org/10.1016/j.arthro.2024.07.004 https://doi.org/10.1002/jeo2.70003 https://doi.org/10.3390/jcm13102994 https://doi.org/10.1136/bjsports-2023-107188 https://doi.org/10.1016/j.ptsp.2024.02.004 https://doi.org/10.1007/s12178-024-09897-9 https://doi.org/10.1177/23259671241239325 https://doi.org/10.1055/a-2270-3233 https://doi.org/10.1016/j.arthro.2023.07.011 https://doi.org/10.3390/jcm13051501 https://doi.org/10.1002/ksa.12081 https://doi.org/10.1123/ijatt.2022-0050 to Return to Sport After ACL Reconstruction as a Risk Factor for Second ACL Injury. Journal of Orthopaedic & Sports Physical Therapy 54:3, 161-17⒌ [Abstract] [Full Text] [PDF] [PDF Plus] [Supplementary Material] 32. Claudio Legnani, Matteo Del Re, Giuseppe M. 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