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IPVS 2012 KOREA 22nd INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS Jeju, Korea June 10-13, 2012 Oral Sessions June 11 (Mon) IPVS 2012 KOREA 22nd INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS NO-049 | Swine Production/Nutrition/Feed-NUTRITION | Diverse sources of Ractopamine affect growth performance differently D Braña1, JR Gabriel2, JA Cuaron1 1CENID-Fisiologia, INIFAP, Queretaro, Mexico, 2FES-C, UNAM, Edo. de Mexico, Mexico, yeyobv@yahoo.com.mx Introduction Ractopamine (RAC) is a phenethanolamine, β-adrenergic receptor agonist that is commercially available (Paylean®, PLN, Elanco, Greenfield, IN, USA), for enhanced muscle protein growth in pigs. After the success of PLN, several companies have developed commercial RAC products of obscure origin and practically nil basic and safety data, presuming that the molecules and their effects would be identical to PLN. The food safety issues are on the verge of responsibility of public health authorities, but effectiveness for pork production is an industry matter that has not been appropriately addressed. The herein experiments were designed to compare growth performance of finishing pigs fed PLN and two commercially available “generic” RAC products (GEN), in two identical independent trials, where consistency of response within batches was also tested. Materials and Methods Trials were two repeated Randomized Complete Block experiments, blocks being consecutive weaning rounds. Within trial, there were 9 Treatments: a Control diet (CON), and 4 different batches (randomly bought) of each RAC source (PLN or GEN), included at 5 ppm in an adequate diet for PLN, to maximize lean growth rate. A total of 528 pigs (half gilts), 238 and 290 in each experiment, were assigned as follow: 106 pigs for the CON, 213 and 209 for PLN or GEN. Animals were individually housed and managed (2.09 m2/pig), fed twice a day and weighed weekly; average daily fat free lean growth (FFL) was estimated by means of real time ultrasound (Aloka 550 SD) measurements. Data were statistically analyzed under the restrictions of the described model, with 9 treatments (CON, 4 PLN and 4 GEN) and 4 blocks. Analyses of variance were facilitated by the General Linear and Mixed Models (SAS) and data are presented as the least square means. Results Initial body weight (Trial 1: 76.6 ±8.32; Trial 2: 84±7.36 kg) was similar (P