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Vol.:(0123456789)1 3 Arch Orthop Trauma Surg DOI 10.1007/s00402-017-2809-5 ARTHROSCOPY AND SPORTS MEDICINE Evidence‑based concepts for prevention of knee and ACL injuries. 2017 guidelines of the ligament committee of the German Knee Society (DKG) Julian Mehl1 · Theresa Diermeier1 · Elmar Herbst1 · Andreas B. Imhoff1 · Thomas Stoffels2 · Thore Zantop3 · Wolf Petersen4 · Andrea Achtnich1 Received: 22 February 2017 © Springer-Verlag GmbH Germany 2017 warm-up exercises and are focusing on muscle strength, bal- ance, and proprioception, as well as running and flexibility. It is reported that these training programs can reduce the incidence of knee injuries by up to 27% and ACL injuries by up to 51%. Conclusions Screening, identification, and correction of endangering movement patterns like the dynamic valgus are the first crucial steps in order to prevent knee and ACL injuries in athletes. Furthermore, jumping, running and flex- ibility exercises as well as balance and strength training are proven to reduce the incidence of these injuries and should, therefore, be integrated into the regular warm up program. Appropriate complete prevention programs are freely acces- sible via the Internet and should be adapted to the specific sport disciplines. Keywords Injury risk · Knee · ACL · Prevention · Screening · Valgus · Core stability · Proprioception Introduction Anterior cruciate ligament (ACL) tears are one of the most frequent injuries of the knee with an estimated incidence of 1:3500 [34, 44]. Due to the typical jumping and stop-and-go movements ACL tears are relatively common in ball sports. However, knee injuries are also frequent in other sports like alpine skiing, judo, and field hockey. The ACL has an important function for knee kinematics, and ACL tears result in serious consequences for the con- cerned athlete. Instability of the knee joint might directly reduce the athlete’s performance. In the long term chronic instability might lead to repetitive subluxations with conse- quently meniscal and cartilage lesions [51–53]. Therefore, Abstract Introduction Knee injuries and especially anterior cruciate ligament (ACL) tears are frequent in athletes. Therefore, pri- mary and secondary prevention of sports-related lower limb injuries is an ongoing topic of interest. The aim of present study was to establish guidelines for the prevention of knee and ACL injuries on the basis of evidence-based concepts represented in current literature. Methods A comprehensive literature review regarding pre- vention programs for knee and ACL injuries was conducted. Results Several modifiable and non-modifiable risk fac- tors for knee injuries in athletes have been reported in lit- erature. Referring to the ACL, specific injury mechanisms have been identified and are well understood. In particular, it has been demonstrated that dynamic valgus is one of the most important modifiable risk factors. Simple tests like the drop jump test have shown their efficacy in screening and detecting athletes at risk. There is only few evidence for the preventive effect on knee and ACL injuries by single exercises. However, in order to prevent or correct endanger- ing movement patterns including dynamic valgus, several complex prevention programs have been developed in the past. These prevention programs are included in standard * Andrea Achtnich a.achtnich@tum.de 1 Department of Orthopaedic Sports Medicine, Klinikum Rechts der Isar, TU Munich, Ismaninger Str. 22, 81675 Munich, Germany 2 Department of Trauma and Orthopaedic Surgery, Unfallkrankenhaus Marzahn, Berlin, Germany 3 Sporthopaedicum Straubing, Straubing, Germany 4 Department of Orthopaedic and Trauma Surgery, Martin-Luther-Krankenhaus, Berlin, Germany Arch Orthop Trauma Surg 1 3 the incidence of osteoarthritis in athletes with an ACL tear is significantly increased [40]. Reconstruction of the ACL decreases the risk of osteoar- thritis [2]; nevertheless, only 50% of athletes return to their pre-injury activity level, which frequently leads to an early end of the athlete’s career [6]. It is also alarming that 7–24% of patients with ACL reconstruction suffer an ACL tear of the contralateral knee [45, 55]. For these reasons primary and secondary prevention of knee injuries is a topic of cur- rent interest. In the past years various strategies for prevention of ACL tears have been developed including following key points [18]: 1. Education about typical injury mechanisms and poten- tial modifications of endangering movements, 2. exercises to improve balance and proprioception, 3. neuromuscular training for inter- and intramuscular coordination, 4. invigoration of the ischiocrural and hip stabilizing mus- cles, and 5. running exercises. These strategies were summarized in special prevention programs (e.g., Sportsmetrics, Prevent Injury and Enhance Performance PEP, Knee Ligament Injury Prevention Pro- gram, FIFA 11) [4]. A recent meta-analysis found a reduc- tion of both knee injuries in general and ACL tears by 27 and 51%, respectively, for patients, who participate in such programs [18]. The aim of this article was to summarize and analyze evidence-based concepts for prevention of knee and ACL injuries. On the basis of these data the ligament commit- tee of the German Knee Society (DKG) wants to provide guidelines in order to reduce the incidence of knee and ACL injuries in athletes. These recommendations are directed to clinicians, physical therapists, athletes’ coaches, and to the athletes themselves. Methods for guideline development The present study was conducted on behalf of the ligament committee of the German Knee Society (DKG). All above- mentioned authors are members of the committee and were involved in the development of the literature search strategy according to a general consensus process as well as in the internal review process. The first part of this article gives a short overview of current aspects of injury mechanisms and the assessment of risk factors for knee and ACL injuries, while the main part discusses different concepts for injury prevention. For this purpose literature was searched for studies, which present preventive exercises or programs and investigate their influence on the incidence of knee and ACL injuries in athletes. The following were the key questions that should be answered by present study: 1. What are the typical injury mechanisms and risk factors for knee and ACL injuries in athletes? 2. Is there evidence for exercises or programs reducing the incidence of knee and ACL injuries in athletes? 3. How can these programs be integrated in the regular training? The recommendations given at the end of this article have been confirmed by all authors unanimously. Injury mechanisms and assessment of risk factors Injury mechanism Video analyses of ACL tears revealed new details about the injury mechanism [9, 63]. According to these studies, in 72–95% of the cases, ACL ruptures occur during non- contact situations [9, 45, 46]. The most dangerous situa- tions for ball sports are as follows: 1. landing after a jump, 2. abrupt stopping, and 3. sudden direction change including rotary knee motion [49, 63]. At the same time the knee is only slightly bended (5°–25° knee flexion) and in a valgus position. In such sit- uations, the in situ forces within the ACL increase remark- ably. In addition it could also cause an impingement of the ACL against the lateral femoral condyle. Most athletes report from a planted foot at the moment of injury. Further, usually the body’s center of gravity is behind of that of the knee. In this position the associated contraction of the quadriceps femoris muscle results in an anterior transla- tionof the tibia with high tension to the ACL. Due to an inappropriate lever arm, the ischiocrural muscles cannot sufficiently protect the ACL against this anteriorly directed force. In addition to that, the hip needs to be flexed in order to maintain the balance, which forces the quadriceps femoris muscle to further contract. By means of surface EMG Colby et al. [12] could demonstrate that this move- ment is connected with high activation of the quadriceps femoris muscle, whereas the activity of the ischiocrural muscles is lower [12]. Arch Orthop Trauma Surg 1 3 Athletes at risk The risk factors for injuries of the knee and in particular the ACL are summarized in Table 1 [3, 52, 57]. Common non-modifiable risk factors ACL re-ruptures are age and gender. Patients under 20 years and female patients have a significantly higher risk for ACL re-ruptures [19, 39]. Also generalized ligamentous laxity is mentioned as one risk fac- tor [3]. Modifiable risk factors are kind of sports, hormone status, and neuromuscular control. Sports at risk are soccer, basketball, handball, and alpine skiing [3]. Several studies could also show an elevated injury risk for females without contraception in the pre-ovulatory phase [3]. With regards to prevention programs, neuromuscular risk factors are of major interest. Various studies could show associated neuromuscular risk factors in athletes [3, 29, 30, 32]. Especially quadriceps femoris muscle dominance, weak knee flexors, and the dynamic valgus-position with defi- ciency in hip and core stability are of importance. It has been observed that in athletes at risk, activation of the quadriceps femoris muscle occurs earlier than for the protective flexors (hamstring muscles) [32]. Furthermore, athletes at risk show general movement pat- terns similar to the knee position identified during injury mechanism analyses: knee valgus (frontal plane) and low flexion angles with the center of gravity behind the knee (sagittal plane). This valgus knee position is also termed as dynamic valgus [3, 29, 57]. In principle, the harmful valgus drift right after a one- legged landing- or stabilization phase- could occur due to decreased hip and core muscle strength with consecutive lateral tilting of the hip to the contralateral side, extended eversion of the lower ankle, missing coordination, and pro- prioceptive skills or by any combination of the aforemen- tioned mechanisms. In athletes at risk proprioceptive defi- ciencies in core control and strength deficits of the external rotators and abductors of the hip could be verified [36, 70]. The dynamic valgus could also arise in the distal part of the ankle (eversion) and foot (external rotation) [56]. Another risk factor in these athletes is an extended “one-leg-domi- nance” [29]. These movement patterns are more common in female athletes [29]. Micromotion studies could demonstrate that landing position is more upright in women compared to men with a less flexed knee and hip. “One-leg dominance” and predominance of strength of the quadriceps femoris muscle is also a typical female phenomenon. Moreover, female ath- letes have an increased valgus position of their knees and deficiencies in hip and core stability. Screening tests Prevention programs are expensive and, therefore, in the past years several tests were developed to identify athletes at risk. The main focus of these tests is to detect functional valgus position of the knees. The “Drop Jump Screening Test” is one of the most com- mon tests [30, 47]. It consists of a vertical jump from a box, in which the landing position is analyzed with a video cam- era (Fig. 1). The frontal projection angle or the distances between both knees and ankles could be measured (knee distance < ankle distance = dynamic valgus). During such landing situations the knee sustains the most uncontrolled movement [47]. Minzner et al. [43] demonstrated a good correlation between the relation of the distances of knee and ankle and two- or three-dimensional video analyses. Noyes et al. [47] showed that this test is also useful to evaluate the success or progression of training focused on the correction of dynamic valgus knee position. In this study the distance between the two knees in female athletes before training was 23 ± 8 cm. After a neuromuscular prevention program the knee distance was increased to 29 ± 8 cm was, therefore, able to reduce the dynamic valgus. Hewett et al. [30] evaluated the “Drop Jump Screen- ing Test” in 205 female athletes (soccer, basketball, Table 1 Risk factors for knee and/or ACL injuries Non-modifiable risk factors Modifiable risk factors Age: < 20 years Gender: female Hormone status: preovulatory phase without contraception Sports: soccer, handball, basketball, alpine skiing Narrow intercondylar notch Generalized ligamentous laxity Pes pronatus valgus Synthetic floor or turf History of muscle, tendon, knee or ankle injuries Infectious disease Poor weather conditions (outdoor sports) Dynamic valgus Low flexion of hip and knee during landing Poor hip and trunk control Weakness of knee flexors and hip abductors (relative to knee extensors) Delayed activation of flexors Proprioceptive deficits Muscle fatigue Poor general fitness Arch Orthop Trauma Surg 1 3 volleyball). This study verified a dynamic valgus position as one risk factor for sustaining an ACL tear. In female athletes with an ACL tear the knee abduction angle was increased by 8° when compared to healthy female controls. In this study, an abduction moment could predict an injury to the ACL with a specificity of 73% and sensitivity of 78%. In the sagittal plane, the authors found a decreased maximum knee flexion angle of 10.5° during landing in athletes with ACL tear compared to healthy athletes (flex- ion angle in athletes with ACL tear: 71.9° ± 12°; flexion angle in athletes without ACL tear: 82.4° ± 8°). Another test for analyzing the dynamic valgus position is the “Single Leg Squat” (Fig. 2) [16]. In the original version of the test the athlete is positioned on a 20-cm box with folded arms: In this position the athlete should perform five single-leg squats with maximum flexion (one squat in 2 s). These squats are recorded by a video cam- era. With different qualitative criteria the performance of the squats is graded in “good”, “middle” and “poor”. The criteria are listed in Table 2. Further, it is also possible to determine the frontal projection angle. Originally this test was designed to evaluate the dynamic valgus position in patients with patellofemoral pain syndrome. Ortiz et al. [48] also used “single leg squats” to assess the effect of a 6 weeks’ ACL prevention program in female soccer play- ers. The authors found a successful reduction of functional valgus during “single leg squats” after performing that Fig. 1 “Drop Jump Screening Test” to detect risk athletes. It con- sists of a vertical jump from a box, in which the landing position is analyzed with a camera. The frontal projection angle or the dis- tances between both knees and ankles could be measured (knee dis- tance < ankle distance = dynamic valgus). During such landing situa- tions the knee sustains the most uncontrolled movement Fig. 2 Another test for analyzing the dynamic valgus position is the “Single Leg Squat” [16]. Therefore, the athlete should perform five single-leg squats with maximum flexion (one squat in 2 s). These squats are recorded by a video camera and graded as “good”, “mid- dle” and “poor” Table 2 Clinical assessment of single-leg squat according Crossley et al. [16] To be classified as “good” in the overall assessment, 4 of 5 criteria have to be fulfilled. Athletes, who fulfill only one criterion, are clas- sified as “poor” CriterionTo be rated “Good” (A) Overall impression 1. Ability to maintain balance 5. No loss of balance 2. Perturbations of the person 6. Smooth performance 3. Depth of the squat 7. Squat with at least 60° of knee flexion 4. Speed of the squat 8. 1 Squat per 2 seconds (B) Trunk posture 9. Lateral deviation 13. No lateral deviation 10. Rotation 14. No rotation 11. Lateral flexion 15. No lateral flexion 12. Forward flexion 16. No forward flexion (C) Pelvic posture 17. Shunt or lateral deviation 20. No shunt or lateral deviation 18. Rotation 21. No rotation 19. Tilt 22. No tilt (D) Hip 23. Adduction 25. No adduction 24. Internal rotation 26. No internal rotation (E) Knee 27. Valgus 29. No valgus 28. Knee to foot position 30. Center of knee over center of foot Arch Orthop Trauma Surg 1 3 prevention program. In these tests a valgus position of the knee was correlated with a reduced hip abduction [1, 16]. The “Functional Movement Screen” (FMS) is another test known in sports science to evaluate the risk of injury [10, 13, 42, 58]. The aim of the FMS is to detect functional asymmetries and disbalances [58]. The athletes have to complete seven different exercises, which are scored with a maximum of three points (three points: perfect performance, two points: evasive movements, one point: exercise is not possible, no point: pain). 14 points and more are associated with an increased risk of injury. Until now this test has been used only rarely for knee injury prevention since the main aim of the test is limited to injury risk assessment [10, 42]. A systematic review demonstrated a specificity of 86% for the FSM, but also a low sensitivity of 25% [18]. The predic- tive value for risk assessment is also low [18]. Therefore, at the moment FSM is not recommended for ACL injury risk assessment. Prevention program Education about mechanism of injury and modification of endangering movement patterns Concluding from the data regarding the genesis of an ACL tear, education about mechanism of injury could be part of prevention. Various studies are supporting this hypothesis. Lephardt et al. [38] using three-dimensional motion analysis demonstrated that endangering movement patterns could be modified with appropriate training. According to Cowling et al. [15], verbal instructions are already suffi- cient to increase the knee flexion angle significantly during landing. The approach for prevention of knee injuries was first described in the “Henning program”, a prevention program for ACL tears in basketball player [22]. The aim of this pro- gram was to modify movement patterns to avoid endanger- ing joint positions. The so-called “plant and cut” maneu- ver should be performed smoothly in single small steps to avoid abrupt motions. During landing, after a jump the knee should be flexed and stopping should also be performed in several small steps and with avoidance of low knee flexion angles. This prevention strategy was educated to the sports- men by means of a video film. With this approach of preven- tion the injury rate was reduced by 89% [23]. Moreover, a study from alpine skiing demonstrated a pre- ventive effect by education regarding injury mechanisms. Within the “Vermont ACL prevention program” athletes were confronted with videos of typical ACL injury situations during skiing. These videos should stimulate the athletes to develop individual prevention strategies [20]. Further- more, the videos should help to detect endangering situa- tions and to develop strategies as a response to the injury stimulus in “almost injury” situations. In the winter season of 1993/94 4700 ski instructors and ski slope patrols took part in this program. Hereby the rate of severe knee injuries was reduced by 62% [20]. In summary, there are certain indications that education about injury mechanism and modification of endangering knee movement patterns could avoid ACL tears (Table 3). The avoidance of dynamic valgus position and landing with flexed knee are the basis for exercises and warm-up programs with the aim to prevent knee and ankle injuries. Balance training Proprioception (afferent information on joint position) rep- resents the sensorial source of information that enables neu- romuscular control of the joint [37]. Proprioceptive informa- tion is given by different mechanoreceptors that are located in muscles, joints (ligaments and capsule), and the skin. In the knee joint this mechanism regulates the interaction between the extensor and flexor muscles, which is crucial for balancing the stress on the ACL but can be practiced by balance training (Fig. 3). It has been shown that exercises on a balance board decrease the incidence of primary and secondary ankle joint injuries [7, 64, 66]. However, current literature is lacking consistent data regarding the benefits of such exercises on Table 3 Avoidance of endangering movements Frontal plane Sagittal plane Avoidance of dynamic valgus Centers of hip, knee, and ankle are aligned During landing after jumping the hip and the knee should be flexed (if possible 90°) and should not be straight Knee pointing externally Body’s center of gravity over the foot Hips are horizontal Trunk is upright Rotation as a smooth movement in single steps Stopping with several small steps and without extended knees Arch Orthop Trauma Surg 1 3 the incidence of ACL injuries. Caraffa et al. [11] conducted a study with 300 male soccer players and found a significant reduction of ACL injuries due to exercises on the balance board [10 ACL injuries in the study group (n = 300) versus 70 ACL tears in the control group (n = 300)]. Wedderkopp et al. [67] analyzed an intervention program including exercises on balance boards as well as muscle strengthening on juvenile female handball players. In this study a decrease of the injury rate by 78% was shown by applying this prevention program. In order to investigate the preventive effect of balance training, another study com- pared two different prevention programs on 16 female hand- ball teams: (1) Standardized strengthening exercises (control group) versus (2) Combination of strengthening exercises and balance board training (study group) [68]. It was found that the incidence of injuries was reduced from 6.9 per 1000 playing hours in the control group to 2.4 injuries per 1000 playing hours in the study group. However, on the basis of the given data a statement regarding knee injuries was not possible. Contrary results were reported by Soderman et al., who conducted a balance board training with 121 juvenile female soccer players [59], while further 100 players served as con- trol group. After one season of observation there was no significant difference between both groups regarding fre- quency of injuries. The incidence of severe injuries was even higher in the intervention group (8 versus 1) with four out of five ACL ruptures in this group. Only in patients, who have had injuries within the past 3 months prior to the beginning of the study, a significant lower injury rate was observed in the intervention group. In summary, on the basis of current data, the usage of balance boards should be recommended as the general inci- dence of injuries can hereby be reduced. In several studies, which demonstrate a positive effect of preventive warm up programs, balance training is included in these programs [41, 46, 49, 50, 54]. Especially the combination of balance exercises with sport-specific exercises is an appropriate sup- plement to warm up programs (Fig. 4). Neuromuscular training Athletes at high risk for ACL injuries are characterized by a dominance of the quadriceps muscle, as on an experimen- tal anterior tibial translation (injury stimulus)these athletes react with quadriceps activation. By contrast, several studies have demonstrated that a rapid activation of the hamstring muscles as a reaction on an injury stimulus helps to protect the knee joint [5, 8, 26, 33, 60]. Fig. 3 Proprioception exercises on a balance board; leg position has to be noted and a dynamic valgus position has to be avoided Fig. 4 Combination of balance exercises with sport-specific exer- cises Arch Orthop Trauma Surg 1 3 Hewett et al. [27] could show that by means of a specific jump training, activation of the hamstring and gluteal mus- cles can be increased and, therefore, also a possible imbal- ance between the quadriceps and the hamstring muscles can be reduced. In this context, it is important that during land- ing, both the athletes knees and hips are flexed by 90°. On the basis of this knowledge the “Cincinnati Sportsmetric Training Program” has been introduced. This prevention program has been tested on 1263 athletes (football, volley- ball, basketball) [28]. It consists of different jumping exer- cises with increasing complexity. In this regard, too, move- ment control based on the principles proposed by Henning [23] is very important in order to avoid endangering move- ment patterns. In the study by Hewett et al. only two athletes of the training group suffered severe injuries compared to ten athletes of the control group. The relative incidence for injuries was 0.12 in the training group and 0.43 in the con- trol group. Summarized, the studies by Hewett et al. [27, 28] show that specific jumping exercises can improve the balance between flexor and extensor muscles at the knee joint; however, consideration of Henning’s principles for movement modifications is crucial [23]. Therefore, jumping exercises have been included in sev- eral warm up programs [41, 46, 49, 50, 54] and are par- ticularly suited for sport disciplines with repetitive jumping tasks. Strength training Because of the crucial role of muscle imbalance in the occurrence of dynamic valgus alignment and the associated risk of ACL tears, strength exercises have been integrated in many prevention programs [17]. These are primarily focus- ing on the knee flexors, hip abductors, and trunk stabilizers [29]. Muscle strength training can be performed using basic training devices at the gym. However, for a better integration of muscle strength training into warm up programs, dynamic exercises have been developed that can be performed by means of simple training tools [29]. Typical strength exercises for ACL prevention are the “Russian hamstrings” [29], which activate the posterior muscle chain both concentrically (upwards) and eccentri- cally (downwards) (Fig. 5). The flexor training on the exercise ball represents a fur- ther possibility to strengthen the posterior thigh muscles as well as the abdominal muscles and the stabilizers of the hip. In addition to that, exercises that strengthen the hip abduc- tors and the hip rotators are included in ACL prevention programs (Fig. 6) [29]. Several studies that could show a positive effect of pre- ventive warm up programs include strength exercises in their warm up programs [21, 35, 41]. Individual strength exercises, however, have not been tested separately so far. Running und flexibility training Running exercises are suitable for injury prevention as they are a classical part of every warm up program. Running and flexibility exercises have been integrated into the “Prevent Injury and Enhance Performance Program” (PEP), which was developed especially for the prevention of ACL injuries in football [21, 41]. It includes different Fig. 5 Muscle strength training: typical exercises for ACL prevention are the “Russian hamstrings”, which activate the posterior muscle chain both concentrically (upwards) and eccentrically (downwards) Fig. 6 Flexor training on the exercise ball represents a possibility to strengthen the posterior thigh muscles as well as the abdominal mus- cles and the stabilizers of the hip Arch Orthop Trauma Surg 1 3 running exercises (e.g., straight ahead running, side steps, running with hip rotation). It is important that the instructors pay special attention to the correct execution of these exer- cises. Above all, a dynamic valgus has to be avoided. Several studies have shown that the PEP can significantly decrease the prevalence of ACL injuries in football players [21, 41]. However, there are no studies, which have investigated the effect of individual running exercises separately. The effect of specific warm up programs on the prevention of ACL ruptures and knee injuries Several systematic reviews and meta-analyses have shown that the risk of knee injuries and ACL ruptures can be sig- nificantly reduced by specific warm up programs [17, 24, 31, 61, 62, 69]. In a meta-analysis of 24 studies, published in 2015, a preventive warm up program could reduce knee injuries by 26.9% and ACL ruptures by 50.7% [17]. Nine of these studies reported additional prevention of musculoskeletal injuries in general. Although the majority of these studies focused on female athletes, a preventive effect could also be demonstrated for male athletes [17]. Most studies have investigated programs that have combined multiple preven- tive concepts: balance training, jumping exercises, strength exercises, running, flexibility exercises, and stretching [17]. However, a meta-regression analysis did not show a signifi- cant effect on the results by any of these individual proce- dures [17]. Only for stretching a little evidence could be shown that it has no effect on the result [25, 65]. Probably the effect of the different preventive procedures is based on modifications of dangerous movement patterns (dynamic valgus, low knee and hip flexion). Therefore, the individual preventive exercises, which are presented in this article, can be combined in such a way that the warm up programs are suitable for the specific sports discipline. Hence, running exercises are suitable for football, jumping exercises for handball or basketball, and strength exercises for skiing. It seems reasonable that these exercises are combined with sport-specific exercises as this can increase the compliance. Furthermore, it could be demonstrated that movements of the upper extremities can influence movement patterns of the lower extremities [14]. There is also evidence that the timing of preventive pro- grams has an influence on the efficacy of risk reduction. Per- forming the preventive training during the pre-season period shows a significantly higher effect than performing it only during the competitive period [17]. Further effects on the efficacy of preventive programs could be shown for duration, frequency, and compliance. The longer the duration of the program (> 20 min) and the more frequent it is conducted (> three times per week), the greater is the effect [61, 62]. Established prevention programs Table 4 gives a summary of different established warm up programs for prevention of knee injuries and ACL ruptures. The preventive effect on primary ACL injuries is scien- tifically proven for most of these programs; however, their effects on the secondary prevention of a re-rupture after ACL reconstruction are still to be investigated. All of these programs are available via Internet. They have been developed specifically for ball sports (football, handball, basketball) and include balance, strength, jumping, Table 4 Overview of established warm up programs for injury prevention R running exercises, P plyometrics (jumping exercises), S strengthening exercises, B balance training, F flexibility training/stretching Name Discipline Exercises Duration (approx.) Scientific evidence Web addressFIFA 11+ Football R, P, S, B 20 min Soligard et al. [61] www.dfb.de/trainer/b-juniorin/ artikel/fifa-11-310/ www.fmarc.com/downloads/ cards/11pluscards_d.pdf www.f-marc.com/1lplus/ startseite/ Prevent injury and enhance performance (PEP) Football R, P, S, F 20 min Mandelbaui et al. [41] smsmf.org/files/PEP_ program_0412201l.pdf Sportsmetrics Football, basketball, tennis, volleyball P, S 60 min Hewett et al. [27, 28] http://sportsmetrics.org/ Harmo Knee Prevention Program Football, basketball R, P, B, F 20–25 min Kiani et al. [35] harmoknee.com “Sei kein Dummy” (prevention program of VBG) Football R, P, S, F 20–30 min – http://www.vbg.de/Shared- Docs/Medien-Center/DE/ Broschuere/Branchen/Sport/ Trainingsuebungen_fuer_ ein_starkes_FuBballteam. pdf?_b Arch Orthop Trauma Surg 1 3 running, and flexibility exercises. The aim of these exercises is to reduce the dynamic valgus and to strengthen the poste- rior muscle chain (flexor muscles of the knee and abductor muscles of the hip). These exercises can be modified and integrated into specific warm up programs of other sports disciplines of high risk (e.g. judo, hockey, skiing). This inte- gration is very useful in order to increase the athletes’ com- pliance. The duration of most of the warm up programs is 20 min. The application of preventive procedures is intensi- fied during the pre-season period, while it is reduced during the competition period. Conclusion and recommendations Especially in non-contact situations there are typical move- ment patterns with increased risk of ACL injuries in ath- letes. Dynamic knee valgus with only slight flexion in the knee and hip joints after landing or during sudden direction change seems to be particularly predisposing. In this respect, several “screening” tests like single-leg squats or jumping tests have been developed, that can help to detect athletes at risk. There is significant evidence that the incidence of knee injuries and ACL ruptures can be reduced by appropriate modifications of the athletes’ training. In this regard preven- tion programs should be based on the following aspects: 1. Information about injury mechanisms, 2. jumping exercises for muscle strengthening and correc- tion of movement patterns, 3. balance training, 4. strength training, 5. running/flexibility exercises. These preventive exercises should be integrated into the usual warm up program in combination with sport-specific exercises. Thus the athlete’s motivation and compliance can be kept high and no further resources are needed. Corre- spondingly several complete warm up programs have already been developed, which are freely accessible via the Internet. However, to date the effectiveness of these programs is only evident for ball sports, while their influence in other sports with higher rates of contact injuries like Judo has not been investigated so far. So, further research is needed in this field. Nevertheless, until further data are available we recommend the same exercises adjusted to the specific warm up programs also for these sports. Acknowledgements The ligament committee of the German Knee Society (DKG) developed this study to provide guidelines regarding the topic prevention of knee and ACL injuries. Members are listed below. Petersen W, Zantop T, Imhoff A, Müller P, Patt T, Scheffler S, Höher J, Stöhr A, Ellermann A, Stoffels T, Jung T, Herbort M, Akoto R, Achtnich A, Diermeier T, Mehl J, Herbst E, Stein T. Compliance with ethical standards Conflict of interest The authors declare that they have no conflict of interest. Funding There is no funding source. Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors. References 1. Ageberg E, Bennell KL, Hunt MA, Simic M, Roos EM, Creaby MW (2010) Validity and inter-rater reliability of mediolateral knee motion observed during a single-limb mini squat. BMC Musculoskelet Disord 11:265 2. 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Am J Sports Med 35(3):368–373 Evidence-based concepts for prevention of knee and ACL injuries. 2017 guidelines of the ligament committee of the German Knee Society (DKG) Abstract Introduction Methods Results Conclusions Introduction Methods for guideline development Injury mechanisms and assessment of risk factors Injury mechanism Athletes at risk Screening tests Prevention program Education about mechanism of injury and modification of endangering movement patterns Balance training Neuromuscular training Strength training Running und flexibility training The effect of specific warm up programs on the prevention of ACL ruptures and knee injuries Established prevention programs Conclusion and recommendations Acknowledgements References