<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/78a32ff7-a307-4973-9e48-7514d08126ef/bg1.png"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls27 ws34">Fármacos colinérgicos </div><div class="t m0 x2 h3 y2 ff2 fs1 fc1 sc0 ls27"><span class="fc4 sc0">J</span></div><div class="t m0 x2 h3 y3 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">Relax</span><span class="fc4 sc0">ant</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span><span class="fc4 sc0">m</span><span class="fc4 sc0">us</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ular</span><span class="fc4 sc0">es</span><span class="fc4 sc0">:</span><span class="fc4 sc0"> </span><span class="fc4 sc0">at</span><span class="fc4 sc0">uam</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y4 ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">e</span><span class="fc4 sc0">m </span><span class="fc4 sc0">n</span><span class="fc4 sc0">í</span><span class="fc4 sc0">ve</span><span class="fc4 sc0">l</span><span class="fc4 sc0"> </span><span class="fc4 sc0">ce</span><span class="fc4 sc0">n</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ra</span><span class="fc4 sc0">l</span></div><div class="t m0 x2 h3 y5 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">B</span><span class="fc4 sc0">loqueador</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y6 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">neur</span><span class="fc4 sc0">om</span><span class="fc4 sc0">us</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ular</span><span class="fc4 sc0">es</span><span class="fc4 sc0">:</span><span class="fc4 sc0"> </span><span class="fc4 sc0">at</span><span class="fc4 sc0">uam</span><span class="fc4 sc0"> </span><span class="fc4 sc0">na </span></div><div class="t m0 x2 h3 y7 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">s</span><span class="fc4 sc0">inaps</span><span class="fc4 sc0">e </span><span class="fc4 sc0">neur</span><span class="fc4 sc0">om</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">or</span><span class="fc4 sc0">a </span></div><div class="t m0 x2 h3 y8 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">Neur</span><span class="fc4 sc0">ônios</span><span class="fc4 sc0"> </span><span class="fc4 sc0">m</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">or</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span><span class="fc4 sc0">(</span><span class="fc4 sc0">ef</span><span class="fc4 sc0">er</span><span class="fc4 sc0">ênc</span><span class="fc4 sc0">ias</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y9 ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">d</span><span class="fc4 sc0">o</span><span class="fc4 sc0"> </span><span class="fc4 sc0">SN</span><span class="fc4 sc0">C</span><span class="fc4 sc0">) </span><span class="fc4 sc0">co</span><span class="fc4 sc0">n</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ro</span><span class="fc4 sc0">l</span><span class="fc4 sc0">a</span><span class="fc4 sc0">m </span><span class="fc4 sc0">o</span><span class="fc4 sc0">s </span></div><div class="t m0 x2 h3 ya ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">m</span><span class="fc4 sc0">ús</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ulos</span><span class="fc4 sc0"> </span><span class="fc4 sc0">es</span><span class="fc4 sc0">t</span><span class="fc4 sc0">r</span><span class="fc4 sc0">iados</span><span class="fc4 sc0"> </span><span class="fc4 sc0">v</span><span class="fc4 sc0">olunt</span><span class="fc4 sc0">ár</span><span class="fc4 sc0">ios</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 yb ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">e</span><span class="fc4 sc0"> </span><span class="fc4 sc0">f</span><span class="fc4 sc0">a</span><span class="fc4 sc0">ze</span><span class="fc4 sc0">m </span><span class="fc4 sc0">u</span><span class="fc4 sc0">ma</span><span class="fc4 sc0"> </span><span class="fc4 sc0">si</span><span class="fc4 sc0">n</span><span class="fc4 sc0">a</span><span class="fc4 sc0">p</span><span class="fc4 sc0">se</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 yc ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">co</span><span class="fc4 sc0">l</span><span class="fc4 sc0">i</span><span class="fc4 sc0">n</span><span class="fc4 sc0">é</span><span class="fc4 sc0">rg</span><span class="fc4 sc0">i</span><span class="fc4 sc0">ca</span><span class="fc4 sc0"> </span><span class="fc4 sc0">co</span><span class="fc4 sc0">m </span><span class="fc4 sc0">a</span><span class="fc4 sc0">s </span><span class="fc4 sc0">f</span><span class="fc4 sc0">i</span><span class="fc4 sc0">b</span><span class="fc4 sc0">ra</span><span class="fc4 sc0">s </span></div><div class="t m0 x2 h3 yd ff2 fs1 fc1 sc0 ls27 ws0"><span class="fc4 sc0">mu</span><span class="fc4 sc0">scu</span><span class="fc4 sc0">l</span><span class="fc4 sc0">a</span><span class="fc4 sc0">re</span><span class="fc4 sc0">s</span></div><div class="t m0 x2 h3 ye ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">Rec</span><span class="fc4 sc0">ept</span><span class="fc4 sc0">or</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span><span class="fc4 sc0">nic</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">í</span><span class="fc4 sc0">nic</span><span class="fc4 sc0">os</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 yf ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">ionot</span><span class="fc4 sc0">r</span><span class="fc4 sc0">ópic</span><span class="fc4 sc0">os</span><span class="fc4 sc0">:</span><span class="fc4 sc0"> </span><span class="fc4 sc0">pr</span><span class="fc4 sc0">om</span><span class="fc4 sc0">ov</span><span class="fc4 sc0">em</span><span class="fc4 sc0"> </span><span class="fc4 sc0">um</span><span class="fc4 sc0">a </span></div><div class="t m0 x2 h3 y10 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">c</span><span class="fc4 sc0">ont</span><span class="fc4 sc0">r</span><span class="fc4 sc0">aç</span><span class="fc4 sc0">ão </span><span class="fc4 sc0">or</span><span class="fc4 sc0">ganiz</span><span class="fc4 sc0">ada </span><span class="fc4 sc0">das</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y11 ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">f</span><span class="fc4 sc0">i</span><span class="fc4 sc0">b</span><span class="fc4 sc0">ra</span><span class="fc4 sc0">s </span><span class="fc4 sc0">mu</span><span class="fc4 sc0">scu</span><span class="fc4 sc0">l</span><span class="fc4 sc0">a</span><span class="fc4 sc0">re</span><span class="fc4 sc0">s</span></div><div class="t m0 x2 h3 y12 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">A</span><span class="fc4 sc0">lguns</span><span class="fc4 sc0"> </span><span class="fc4 sc0">m</span><span class="fc4 sc0">edic</span><span class="fc4 sc0">am</span><span class="fc4 sc0">ent</span><span class="fc4 sc0">os</span><span class="fc4 sc0"> </span><span class="fc4 sc0">at</span><span class="fc4 sc0">uam</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y13 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">nes</span><span class="fc4 sc0">s</span><span class="fc4 sc0">a </span><span class="fc4 sc0">s</span><span class="fc4 sc0">inaps</span><span class="fc4 sc0">e </span><span class="fc4 sc0">neur</span><span class="fc4 sc0">om</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">or</span><span class="fc4 sc0">a</span></div><div class="t m0 x2 h3 y14 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">Cur</span><span class="fc4 sc0">ar</span><span class="fc4 sc0">e:</span><span class="fc4 sc0"> </span><span class="fc4 sc0">pr</span><span class="fc4 sc0">epar</span><span class="fc4 sc0">aç</span><span class="fc4 sc0">ão </span><span class="fc4 sc0">de </span><span class="fc4 sc0">v</span><span class="fc4 sc0">ár</span><span class="fc4 sc0">ias</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y15 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">s</span><span class="fc4 sc0">ubs</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ânc</span><span class="fc4 sc0">ias</span><span class="fc4 sc0">,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">dent</span><span class="fc4 sc0">r</span><span class="fc4 sc0">e </span><span class="fc4 sc0">elas</span><span class="fc4 sc0"> </span><span class="fc4 sc0">a </span></div><div class="t m0 x2 h3 y16 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">t</span><span class="fc4 sc0">uboc</span><span class="fc4 sc0">ur</span><span class="fc4 sc0">ar</span><span class="fc4 sc0">ina,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">que </span><span class="fc4 sc0">é </span><span class="fc4 sc0">um</span><span class="fc4 sc0"> </span><span class="fc4 sc0">pot</span><span class="fc4 sc0">ent</span><span class="fc4 sc0">e </span></div><div class="t m0 x2 h3 y17 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">bloqueador</span><span class="fc4 sc0"> </span><span class="fc4 sc0">m</span><span class="fc4 sc0">us</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ular</span><span class="blank _0"></span><span class="fc4 sc0">,</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y18 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">c</span><span class="fc4 sc0">aus</span><span class="fc4 sc0">ando </span><span class="fc4 sc0">um</span><span class="fc4 sc0">a </span><span class="fc4 sc0">par</span><span class="fc4 sc0">alis</span><span class="fc4 sc0">ia </span></div><div class="t m0 x2 h3 y19 ff2 fs1 fc1 sc0 ls27 ws34"><span class="fc4 sc0">i</span><span class="fc4 sc0">me</span><span class="fc4 sc0">d</span><span class="fc4 sc0">i</span><span class="fc4 sc0">a</span><span class="fc4 sc0">t</span><span class="fc4 sc0">a</span><span class="fc4 sc0"> </span><span class="fc4 sc0">e</span><span class="fc4 sc0"> </span><span class="fc4 sc0">mo</span><span class="fc4 sc0">rt</span><span class="fc4 sc0">e</span><span class="fc4 sc0"> </span><span class="fc4 sc0">p</span><span class="fc4 sc0">o</span><span class="fc4 sc0">r </span><span class="fc4 sc0">a</span><span class="fc4 sc0">sf</span><span class="fc4 sc0">i</span><span class="fc4 sc0">xi</span><span class="fc4 sc0">a</span></div><div class="t m0 x2 h3 y1a ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">O</span><span class="fc4 sc0">s</span><span class="fc4 sc0"> </span><span class="fc4 sc0">bloqueador</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y1b ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">neur</span><span class="fc4 sc0">om</span><span class="fc4 sc0">us</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ular</span><span class="fc4 sc0">es</span><span class="fc4 sc0"> </span><span class="fc4 sc0">não </span><span class="fc4 sc0">pos</span><span class="fc4 sc0">s</span><span class="fc4 sc0">uem</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y1c ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">out</span><span class="fc4 sc0">r</span><span class="fc4 sc0">a </span><span class="fc4 sc0">pr</span><span class="fc4 sc0">opr</span><span class="fc4 sc0">iedade </span><span class="fc4 sc0">s</span><span class="fc4 sc0">e </span><span class="fc4 sc0">não </span></div><div class="t m0 x2 h3 y1d ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">par</span><span class="fc4 sc0">alis</span><span class="fc4 sc0">ar</span><span class="fc4 sc0"> </span><span class="fc4 sc0">(</span><span class="fc4 sc0">não </span><span class="fc4 sc0">alt</span><span class="fc4 sc0">er</span><span class="fc4 sc0">am</span><span class="fc4 sc0"> </span><span class="fc4 sc0">o </span><span class="fc4 sc0">es</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ado </span></div><div class="t m0 x2 h3 y1e ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">de </span><span class="fc4 sc0">c</span><span class="fc4 sc0">ons</span><span class="fc4 sc0">c</span><span class="fc4 sc0">iênc</span><span class="fc4 sc0">ia,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">não </span><span class="fc4 sc0">pr</span><span class="fc4 sc0">ov</span><span class="fc4 sc0">oc</span><span class="fc4 sc0">am</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y1f ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">anes</span><span class="fc4 sc0">t</span><span class="fc4 sc0">es</span><span class="fc4 sc0">ia,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">não </span><span class="fc4 sc0">ac</span><span class="fc4 sc0">ar</span><span class="fc4 sc0">r</span><span class="fc4 sc0">et</span><span class="fc4 sc0">am</span><span class="fc4 sc0"> </span></div><div class="t m0 x2 h3 y20 ff2 fs1 fc1 sc0 ls0 ws1"><span class="fc4 sc0">analges</span><span class="fc4 sc0">ia)</span></div><div class="t m0 x3 h3 y21 ff2 fs1 fc1 sc0 ls27 ws34">- Relaxantes musculares: atuam em nível central</div><div class="t m0 x3 h3 y22 ff2 fs1 fc1 sc0 ls0 ws34">- Bloqueadores neuromusculares: atuam na sinapse </div><div class="t m0 x3 h3 y23 ff2 fs1 fc1 sc0 ls0 ws34">neuromotora </div><div class="t m0 x3 h3 y24 ff2 fs1 fc1 sc0 ls27 ws34">- Receptores nicotínicos ionotrópicos: promovem uma </div><div class="t m0 x3 h3 y25 ff2 fs1 fc1 sc0 ls0 ws34">contração organizada das fibras musculares. <span class="blank _0"></span>Alguns </div><div class="t m0 x3 h3 y26 ff2 fs1 fc1 sc0 ls0 ws34">medicamentos atuam nessa sinapse neuromotora</div><div class="t m0 x3 h3 y27 ff2 fs1 fc1 sc0 ls27 ws34">- <span class="ff3 ls0 ws1">Curare</span><span class="ls0">: preparação de várias substâncias, dentre elas </span></div><div class="t m0 x3 h3 y28 ff2 fs1 fc1 sc0 ls0 ws34">a tubocurarina, que é um potente bloqueador muscular<span class="blank _0"></span>, </div><div class="t m0 x3 h3 y29 ff2 fs1 fc1 sc0 ls0 ws34">causando uma <span class="ff4">paralisia imediata</span><span class="ls28"> e <span class="ff4 ls27">morte por asfixia<span class="ff2">.</span></span></span></div><div class="t m0 x4 h3 y2a ff2 fs1 fc1 sc0 ls0 ws1">Rocurônio</div><div class="t m0 x5 h4 y2b ff1 fs2 fc2 sc0 ls27 ws34">R<span class="blank _1"></span>eceptor nicotínico de acetilcolina</div><div class="t m0 x3 h3 y2c ff2 fs1 fc1 sc0 ls0 ws34">- Medeia a neurotransrmissão pos-sináptica na junção neuromuscular e nos gânglios </div><div class="t m0 x3 h3 y2d ff2 fs1 fc1 sc0 ls0 ws34">autônomos periféricos</div><div class="t m0 x3 h3 y2e ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">No </span><span class="ff3 ws0">SNC</span><span class="ff2 ls0">: controla a liberação dos neurotransmissores pelas estruturas pré-sinápticas</span></div><div class="t m0 x3 h3 y2f ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Pode ser estimulado pelo alcaloide nicotina e pelo neurotransmissor <span class="blank _0"></span>ACh</span></div><div class="t m0 x3 h3 y30 ff2 fs1 fc1 sc0 ls27 ws34">Existem diferentes subtipos de receptores nicotínicos, e vários fármacos que atuam </div><div class="t m0 x3 h3 y31 ff2 fs1 fc1 sc0 ls0 ws34">nesses receptores conseguem diferenciá-los</div><div class="t m0 x3 h5 y32 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ls1">L<span class="ff2 ls0">igação da <span class="blank _0"></span>ACh ao receptor nicotínico<span class="ff5 ls27">: </span>inicia o potencial da placa terminal (PPT) nos </span></span></div><div class="t m0 x3 h3 y33 ff2 fs1 fc1 sc0 ls0 ws34">músculos ou o potencial pós-sináptico excitatório (PPSE) nos gânglios periféricos<span class="ff5 ls27">.</span></div><div class="t m0 x5 h4 y34 ff1 fs2 fc2 sc0 ls27 ws34">Antagonistas de receptores nicotínicos musculares</div><div class="t m0 x6 h4 y35 ff1 fs2 fc2 sc0 ls27 ws34">Fármacos que atuam na junção neuromuscular </div><div class="t m0 x7 h6 y36 ff1 fs3 fc3 sc0 ls27 ws34">Não despolarizantes <span class="blank _2"> </span><span class="ws2 v1">Despolarizantes</span><span class="fs2 v1"> </span></div><div class="t m0 x8 h3 y37 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2">Antagonistas dos receptores nicotínicos </span></div><div class="t m0 x8 h3 y38 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Impedem a ativação do receptor nicotínico pela </span></div><div class="t m0 x8 h3 y39 ff2 fs1 fc1 sc0 ls27 ws0">ACh</div><div class="t m0 x8 h5 y3a ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">B</span><span class="ff2">aixo Kd - Maior tempo de ação</span></div><div class="t m0 x8 h5 y3b ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">A</span><span class="ff2 ls28">finidade </span><span class="ws0">>>></span><span class="ff2"> <span class="blank _0"></span>ACh sobre esses receptores</span></div><div class="t m0 x8 h5 y3c ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">E</span><span class="ff2 ls0">liminação hepática e renal, exceto o mivacúrio </span></div><div class="t m0 x8 h3 y3d ff2 fs1 fc1 sc0 ls0 ws34">(degradado pela colinesterase plasmática)</div><div class="t m0 x9 h3 y3e ff2 fs1 fc1 sc0 ls0 ws1">T<span class="blank _0"></span>ubocurarina</div><div class="t m0 x9 h3 y3f ff2 fs1 fc1 sc0 ls0 ws1">Doxacurônio</div><div class="t m0 x4 h3 y40 ff2 fs1 fc1 sc0 ls0 ws34">Pancurônio </div><div class="t m0 xa h3 y41 ff2 fs1 fc1 sc0 ls0 ws34">Pipecurônio </div><div class="t m0 xb h3 y42 ff2 fs1 fc1 sc0 ls27 ws0">Atracúrio</div><div class="t m0 xc h5 y43 ff6 fs1 fc1 sc0 ls2">M<span class="ff2 ls27 ws0">ivacúrio</span></div><div class="t m0 xd h5 y44 ff6 fs1 fc1 sc0 ls3">C<span class="ff2 ls27 ws0">isatracúrio</span></div><div class="t m0 x4 h5 y45 ff6 fs1 fc1 sc0 ls27 ws3">V<span class="ff2 ls0 ws1">ecurônio</span></div><div class="t m0 xc h5 y46 ff6 fs1 fc1 sc0 ls2">M<span class="ff2 ls27 ws0">ivacúrio</span></div><div class="t m0 xe h3 y47 ff2 fs1 fc1 sc0 ls27 ws34">- <span class="blank _0"></span>Agonistas nicotínicos </div><div class="t m0 xe h3 y48 ff2 fs1 fc1 sc0 ls0 ws34">- <span class="blank _0"></span>Ativam o neurônio, provocando uma </div><div class="t m0 xe h3 y49 ff2 fs1 fc1 sc0 ls0 ws34">despolarização da fibra muscular<span class="blank _0"></span>. </div><div class="t m0 xe h3 y4a ff2 fs1 fc1 sc0 ls0 ws34">Contudo, a despolarização é exacerbada </div><div class="t m0 xe h3 y4b ff2 fs1 fc1 sc0 ls0 ws34">e desorganizada (excesso de <span class="blank _0"></span>ACh/</div><div class="t m0 xe h3 y4c ff2 fs1 fc1 sc0 ls0 ws1">agonista).</div><div class="t m0 xf h5 y4d ff6 fs1 fc1 sc0 ls0 ws4">Principal<span class="ff5 ls27 ws34"> </span>representante<span class="ff5 ls27 ws34">: </span></div><div class="t m0 xf h7 y4e ff3 fs1 fc1 sc0 ls0">succinilcolina</div><div class="t m0 xf h5 y4f ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ls4">M<span class="ff2 ls0">ecanismo de ação </span></span></div><div class="t m0 xf h3 y50 ff2 fs1 fc1 sc0 ls0 ws34">muito rápido </div><div class="t m0 xf h3 y51 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Degradada pela </span></div><div class="t m0 xf h3 y52 ff2 fs1 fc1 sc0 ls0 ws34">colinesterase sérica e </div><div class="t m0 xf h3 y53 ff2 fs1 fc1 sc0 ls0 ws1">hepática<span class="ff7 ls27 ws34"> \u2192<span class="ff5"> </span></span><span class="ws34">diminui a </span></div><div class="t m0 xf h3 y54 ff2 fs1 fc1 sc0 ls0 ws34">possibilidade de interação </div><div class="t m0 xf h3 y55 ff2 fs1 fc1 sc0 ls0 ws1">medicamentosa</div><div class="t m0 xf h5 y56 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">t</span> <span class="ff2 ws0">recuperaçã<span class="ff6 ls5">o</span></span><span class="ls6">:</span><span class="ff2"> 10 mim</span></div><div class="t m0 xf h5 y57 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">t</span> <span class="ff6 ws3">f<span class="ff2 ls0 ws1">asciculações</span></span>: <span class="ff2">30s </span></div><div class="t m0 xf h5 y58 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">t</span> <span class="ff2 ls0 ws1">paralisia</span>: <span class="ff2 ls0">60s</span></div><div class="t m0 xf h5 y59 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ls7">B<span class="ff2 ls0">loqueio em duas fases</span></span>: </div><div class="t m0 xf h5 y5a ff6 fs1 fc1 sc0 ls0 ws4">fasciculações<span class="ff5 ls27 ws34"> </span>no<span class="ff5 ls27 ws34"> <span class="ff6 ws3">músculo</span> </span></div><div class="t m0 xf h5 y5b ff6 fs1 fc1 sc0 ls5">e<span class="ff5 ls27 ws34"> </span><span class="ls0 ws4">repolarização</span></div><div class="t m0 xf h3 y5c ff2 fs1 fc1 sc0 ls0 ws34">- De escolha na intubação</div><div class="t m0 x10 h3 y5d ff3 fs1 fc1 sc0 ls27 ws34">Sequência de paralisia<span class="ff2">: pálpebras e músculos faciais (primeiros a </span></div><div class="t m0 x10 h3 y5e ff2 fs1 fc1 sc0 ls27 ws34">se paralisarem); extremidades e membros; músculos intercostais; </div><div class="t m0 x10 h3 y5f ff2 fs1 fc1 sc0 ls0 ws34">diafragma (último a se paralisar)</div><div class="t m0 x10 h3 y60 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Músculos periféricos são os primeiros a sofrerem o bloqueio </span></div><div class="t m0 x10 h3 y61 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Músculos respiratórios são os últimos a sofrerem o bloqueio</span></div><div class="t m0 x10 h3 y62 ff3 fs1 fc1 sc0 ls0 ws34">Usos clínicos<span class="ff2">: relaxamento cirúrgico, intubação traqueal, ortopedia </span></div><div class="t m0 x10 h3 y63 ff2 fs1 fc1 sc0 ls0 ws34">(redução/estabilização), controle de ventilação, convulsões (raro)</div><div class="t m1 x11 h8 y64 ff8 fs4 fc4 sc0 ls27"><span class="fc4 sc0">\</span></div><div class="t m2 x12 h9 y65 ff8 fs5 fc4 sc0 ls27"><span class="fc4 sc0">e</span></div><div class="t m3 x11 ha y66 ff8 fs6 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m4 x13 hb y67 ff8 fs7 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m5 x11 hc y68 ff8 fs8 fc4 sc0 ls27"><span class="fc4 sc0">/</span></div><div class="t m6 x12 hd y69 ff8 fs9 fc4 sc0 ls27"><span class="fc4 sc0">a</span></div><div class="t m7 x14 he y6a ff8 fsa fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m8 x15 hf y6b ff8 fsb fc4 sc0 ls8 ws5"><span class="fc4 sc0">P</span><span class="blank _0"></span><span class="fc4 sc0">ARALI</span><span class="fc4 sc0">SI</span><span class="fc4 sc0">A</span></div><div class="t m9 x16 h10 y6c ff8 fsc fc4 sc0 ls9 ws6"><span class="fc4 sc0">FLÁ</span><span class="fc4 sc0">CI</span><span class="fc4 sc0">D</span><span class="blank _0"></span><span class="fc4 sc0">A</span></div><div class="t ma x17 h11 y6d ff8 fsd fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t mb x18 h12 y6e ff8 fse fc4 sc0 ls29"><span class="fc4 sc0">Nat</span></div><div class="t mc x19 h13 y6f ff8 fsf fc4 sc0 ls27"><span class="fc4 sc0">/</span></div><div class="t md x1a h14 y70 ff8 fs10 fc4 sc0 lsa ws7"><span class="fc4 sc0">De</span><span class="fc4 sc0">ri</span><span class="fc4 sc0">v</span><span class="fc4 sc0">ad</span><span class="fc4 sc0">os</span></div><div class="t me x4 h15 y71 ff8 fs11 fc4 sc0 ls2a"><span class="fc4 sc0">de</span></div><div class="t mf x1b h16 y72 ff8 fs12 fc4 sc0 ls27"><span class="fc4 sc0">:</span></div><div class="t m10 x1c h17 y73 ff8 fs13 fc4 sc0 ls2b ws8"><span class="fc4 sc0">PO</span><span class="fc4 sc0">T</span><span class="fc4 sc0">Ê</span><span class="blank _0"></span><span class="fc4 sc0">NCI</span><span class="fc4 sc0">A</span></div><div class="t m11 x1d h18 y74 ff9 fs14 fc4 sc0 ls27"><span class="fc4 sc0">%</span></div><div class="t m12 x1e h19 y75 ff9 fs15 fc4 sc0 ls2c"><span class="fc4 sc0">:c</span></div><div class="t m13 x1f h1a y76 ff9 fs16 fc4 sc0 ls2d"><span class="fc4 sc0">:c</span></div><div class="t m14 x20 h1b y77 ff9 fs17 fc4 sc0 ls2e"><span class="fc4 sc0">:S</span></div><div class="t m15 x21 h1c y78 ff9 fs18 fc4 sc0 ls2f"><span class="fc4 sc0">:*</span></div><div class="t m16 x22 h1d y79 ff9 fs19 fc4 sc0 ls30"><span class="fc4 sc0">:*</span></div><div class="t m17 x23 h1e y7a ff8 fs1a fc4 sc0 ls27"><span class="fc4 sc0">"</span></div><div class="t m18 x24 h1f y7b ff8 fs1b fc4 sc0 ls27"><span class="fc4 sc0">"</span></div><div class="t m19 x25 h20 y7c ffa fs1c fc4 sc0 ls27"><span class="fc4 sc0">\u20ac</span></div><div class="t m1a x26 h21 y7d ff9 fs1d fc4 sc0 lsb ws9"><span class="fc4 sc0">:</span><span class="fc4 sc0">÷÷÷÷÷</span></div><div class="t m1b x27 h22 y7e ff9 fs1e fc4 sc0 ls31"><span class="fc4 sc0">.in:9?t!:::?!!i</span></div><div class="t m1c x28 h23 y7f ff9 fs1f fc4 sc0 ls27"><span class="fc4 sc0">:</span></div><div class="t m1d x29 h24 y80 ff8 fs20 fc4 sc0 lsc wsa"><span class="fc4 sc0">Ele</span><span class="fc4 sc0">s</span></div><div class="t m1e x2a h25 y81 ff8 fs21 fc4 sc0 lsd wsb"><span class="fc4 sc0">p</span><span class="fc4 sc0">aram</span></div><div class="t m1f x2b h26 y82 ff8 fs22 fc4 sc0 ls32"><span class="fc4 sc0">de</span></div><div class="t m20 x2c h27 y83 ff8 fs23 fc4 sc0 lse wsc"><span class="fc4 sc0">r</span><span class="fc4 sc0">esponder</span></div><div class="t m21 x2d h28 y84 ff8 fs24 fc4 sc0 ls27"><span class="fc4 sc0">a</span></div><div class="t m22 x2e h29 y85 ff8 fs25 fc4 sc0 lsf wsd"><span class="fc4 sc0">Ele</span><span class="fc4 sc0">s</span></div><div class="t m23 x1f h2a y86 ff8 fs26 fc4 sc0 ls10 wse"><span class="fc4 sc0">nã</span><span class="fc4 sc0">o</span></div><div class="t m24 x2f h2b y87 ff8 fs27 fc4 sc0 ls11 wsf"><span class="fc4 sc0">alt</span><span class="fc4 sc0">e</span><span class="fc4 sc0">ram</span></div><div class="t m25 x30 h2c y88 ff8 fs28 fc4 sc0 ls27"><span class="fc4 sc0">o</span></div><div class="t m26 x31 h2d y89 ff8 fs29 fc4 sc0 ls12 ws10"><span class="fc4 sc0">es</span><span class="fc4 sc0">ta</span><span class="fc4 sc0">do</span></div><div class="t m27 x32 h2e y8a ff8 fs2a fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m28 x33 h2f y8b ff8 fs2b fc4 sc0 ls13 ws11"><span class="fc4 sc0">con</span><span class="fc4 sc0">d</span><span class="fc4 sc0">ut</span><span class="fc4 sc0">ân</span><span class="fc4 sc0">ci</span><span class="fc4 sc0">a</span></div><div class="t m29 x34 h30 y8c ff8 fs2c fc4 sc0 ls33"><span class="fc4 sc0">dos</span></div><div class="t m2a x35 h31 y8d ff8 fs2d fc4 sc0 ls34"><span class="fc4 sc0">íons</span></div><div class="t m2b x1 h32 y8e ff8 fs2e fc4 sc0 ls35"><span class="fc4 sc0">de</span></div><div class="t m2c x36 h33 y8f ff8 fs2f fc4 sc0 ls14 ws12"><span class="fc4 sc0">c</span><span class="fc4 sc0">o</span><span class="fc4 sc0">nsc</span><span class="fc4 sc0">iênc</span><span class="fc4 sc0">ia</span></div><div class="t m2d x37 h34 y90 ff8 fs30 fc4 sc0 ls27"><span class="fc4 sc0">,</span></div><div class="t m2e x38 h35 y91 ff8 fs31 fc4 sc0 ls15 ws13"><span class="fc4 sc0">nã</span><span class="fc4 sc0">o</span></div><div class="t m2f x22 h36 y92 ff8 fs32 fc4 sc0 ls36 ws14"><span class="fc4 sc0">pr</span><span class="fc4 sc0">o</span><span class="fc4 sc0">v</span><span class="blank _0"></span><span class="fc4 sc0">o</span></div><div class="t m30 x39 h37 y93 ff8 fs33 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m31 x3a h38 y94 ff8 fs34 fc4 sc0 ls37 ws15"><span class="fc4 sc0">oaman</span><span class="fc4 sc0">aig</span><span class="fc4 sc0">es</span><span class="fc4 sc0">iae</span></div><div class="t m32 x30 h39 y95 ff8 fs35 fc4 sc0 ls38 ws16"><span class="fc4 sc0">an</span><span class="fc4 sc0">e</span><span class="fc4 sc0">s</span><span class="fc4 sc0">t</span><span class="fc4 sc0">e</span><span class="fc4 sc0">s</span><span class="fc4 sc0">ia</span></div><div class="t m33 x32 h3a y96 ffb fs36 fc4 sc0 ls27"><span class="fc4 sc0">\u21b3</span></div><div class="t m34 x23 h3b y97 ff9 fs37 fc4 sc0 ls16 ws17"><span class="fc4 sc0">MÉDI</span><span class="fc4 sc0">ÁÊÍ</span><span class="fc4 sc0">ÊÊÍ</span><span class="fc4 sc0">Í</span><span class="fc4 sc0">Ê</span></div><div class="t m35 x16 h3c y98 ff8 fs38 fc4 sc0 ls39 ws18"><span class="fc4 sc0">.mg</span><span class="fc4 sc0">?g</span><span class="fc4 sc0">oi?!!in</span><span class="fc4 sc0">min</span><span class="fc4 sc0">moaue</span><span class="fc4 sc0">ioaa</span><span class="blank _3"></span><span class="fc4 sc0">T</span><span class="blank _3"></span><span class="fc4 sc0">n</span><span class="blank _4"></span><span class="fc4 sc0">w</span><span class="blank _0"></span><span class="fc4 sc0">a</span></div><div class="t m36 x3b h3d y99 ff8 fs39 fc4 sc0 ls17 ws19"><span class="fc4 sc0">musc</span><span class="fc4 sc0">ular</span></div><div class="t m37 x3c h3e y9a ff8 fs3a fc4 sc0 ls3a ws1a"><span class="fc4 sc0">td</span><span class="fc4 sc0">e</span><span class="fc4 sc0">r</span><span class="fc4 sc0">e</span><span class="fc4 sc0">c</span><span class="fc4 sc0">u</span><span class="fc4 sc0">p</span></div><div class="t m38 x3d h3f y9b ff8 fs3b fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m39 x3e h40 y9c ff8 fs3c fc4 sc0 ls18 ws1b"><span class="fc4 sc0">ftn</span><span class="fc4 sc0">idj</span></div><div class="t m3a x3f h41 y9d ff8 fs3d fc4 sc0 ls19 ws1c"><span class="fc4 sc0">Músc</span><span class="fc4 sc0">ulo</span></div><div class="t m3b x40 h42 y9e ff8 fs3e fc4 sc0 ls1a ws1d"><span class="fc4 sc0">sis</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ema</span></div><div class="t m3c x37 h43 y9f ff8 fs3f fc4 sc0 ls1b ws1e"><span class="fc4 sc0">ef</span><span class="fc4 sc0">er</span><span class="fc4 sc0">ent</span><span class="fc4 sc0">e</span></div><div class="t m3d x32 h44 ya0 ff8 fs40 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m3e x12 h45 ya1 ff8 fs41 fc4 sc0 ls27"><span class="fc4 sc0">(</span></div><div class="t m3f x26 h46 ya2 ff8 fs42 fc4 sc0 ls3b"><span class="fc4 sc0">dose</span></div><div class="t m40 x41 h47 ya3 ff8 fs43 fc4 sc0 ls3c"><span class="fc4 sc0">maior</span></div><div class="t m41 x42 h48 ya4 ff8 fs44 fc4 sc0 ls27"><span class="fc4 sc0">~</span></div><div class="t m42 x43 h49 ya5 ff8 fs45 fc4 sc0 ls27"><span class="fc4 sc0">"</span></div><div class="t m43 x44 h4a ya6 ff8 fs46 fc4 sc0 ls3d ws1f"><span class="fc4 sc0">97</span><span class="fc4 sc0">¥</span></div><div class="t m44 x45 h4b ya7 ff8 fs47 fc4 sc0 ls27"><span class="fc4 sc0">"</span></div><div class="t m45 x1d h4c ya8 ff8 fs48 fc4 sc0 ls27"><span class="fc4 sc0">"</span></div><div class="t m46 x46 h4d ya9 ff8 fs49 fc4 sc0 ls27"><span class="fc4 sc0">}</span></div><div class="t m47 x47 h4e yaa ff8 fs4a fc4 sc0 ls1c ws20"><span class="fc4 sc0">so</span><span class="fc4 sc0">má</span><span class="fc4 sc0">tic</span><span class="fc4 sc0">o</span></div><div class="t m48 x32 h4f yab ffc fs4b fc4 sc0 ls27"><span class="fc4 sc0">_</span></div><div class="t m49 x48 h50 yac ff8 fs4c fc4 sc0 ls3e ws21"><span class="fc4 sc0">BAI</span><span class="fc4 sc0">X</span><span class="fc4 sc0">A</span></div><div class="t m4a x3c h51 yad ff8 fs4d fc4 sc0 ls3f ws22"><span class="fc4 sc0">td</span><span class="fc4 sc0">e</span><span class="fc4 sc0">i</span><span class="fc4 sc0">n</span><span class="fc4 sc0">i</span><span class="blank _5"> </span><span class="fc4 sc0">c</span><span class="fc4 sc0">i</span><span class="fc4 sc0">o</span><span class="fc4 sc0">d</span><span class="fc4 sc0">e</span><span class="blank _5"> </span><span class="fc4 sc0">a</span><span class="fc4 sc0">ç</span><span class="fc4 sc0">ã</span><span class="fc4 sc0">a</span><span class="fc4 sc0">c</span><span class="blank _5"> </span><span class="fc4 sc0">o</span><span class="fc4 sc0">o</span><span class="fc4 sc0">s</span></div><div class="t m4b x42 h52 yae ff8 fs4e fc4 sc0 ls27"><span class="fc4 sc0">o</span></div><div class="t m4c x26 h53 yaf ff8 fs4f fc4 sc0 ls40"><span class="fc4 sc0">tt</span></div><div class="t m4d x49 h54 yb0 ff8 fs50 fc4 sc0 ls1d ws23"><span class="fc4 sc0">r</span><span class="fc4 sc0">ec</span><span class="fc4 sc0">uperaç</span><span class="fc4 sc0">ão</span></div><div class="t m4e x4a h55 yb1 ff8 fs51 fc4 sc0 ls27"><span class="fc4 sc0">:</span></div><div class="t m4f x4b h56 yb2 ff8 fs52 fc4 sc0 ls1e ws24"><span class="fc4 sc0">10-</span><span class="fc4 sc0">20</span></div><div class="t m50 x4c h57 yb3 ff8 fs53 fc4 sc0 ls41"><span class="fc4 sc0">min</span></div><div class="t m51 x42 h58 yb4 ff8 fs54 fc4 sc0 ls27"><span class="fc4 sc0">\u2022</span></div><div class="t m52 x42 h59 yb5 ff8 fs55 fc4 sc0 ls42"><span class="fc4 sc0">1-</span></div><div class="t m53 x4d h5a yb6 ff8 fs56 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m54 x42 h5b yb7 ffd fs57 fc4 sc0 ls27"><span class="fc4 sc0">\u20ac</span></div><div class="t m55 x3d h5c yb8 ff8 fs58 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m56 x4e h5d yb9 ff8 fs59 fc4 sc0 ls43 ws25"><span class="fc4 sc0">FE</span><span class="fc4 sc0">I</span></div><div class="t m57 x4f h5e yba ff8 fs5a fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m58 x50 h5f ybb ff9 fs5b fc4 sc0 ls44 ws26"><span class="fc4 sc0">Na</span><span class="fc4 sc0">t</span><span class="blank"> </span><span class="fc4 sc0">s</span><span class="blank"> </span><span class="fc4 sc0">u</span><span class="blank"> </span><span class="fc4 sc0">k</span><span class="blank"> </span><span class="fc4 sc0">i</span></div><div class="t m59 x51 h60 ybc ff8 fs5c fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m5a x24 h61 ybd ff8 fs5d fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m5b x42 h62 ybe ff8 fs5e fc4 sc0 ls27"><span class="fc4 sc0">É</span></div><div class="t m5c x3d h63 ybf ff9 fs5f fc4 sc0 ls45 ws27"><span class="fc4 sc0">-1</span><span class="blank"> </span><span class="fc4 sc0">¥</span></div><div class="t m5d x4f h64 yc0 ff8 fs60 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m5e x52 h65 yc1 ff9 fs61 fc4 sc0 ls1f ws28"><span class="fc4 sc0">imdb</span><span class="blank _4"></span><span class="fc4 sc0">.</span><span class="blank _0"></span><span class="fc4 sc0">gs</span></div><div class="t m5f x3f h66 yc2 ff8 fs62 fc4 sc0 ls46"><span class="fc4 sc0">:*</span></div><div class="t m60 x11 h67 yc3 ff9 fs63 fc4 sc0 ls47"><span class="fc4 sc0">:*</span></div><div class="t m61 x53 h68 yc4 ff8 fs64 fc4 sc0 ls48"><span class="fc4 sc0">:S</span></div><div class="t m62 x46 h69 yc5 ff9 fs65 fc4 sc0 ls27"><span class="fc4 sc0">}</span></div><div class="t m63 x2f h6a yc6 ff8 fs66 fc4 sc0 ls49 ws29"><span class="fc4 sc0">ins</span><span class="fc4 sc0">ta</span></div><div class="t m64 x54 h6b yc7 ff8 fs67 fc4 sc0 ls27"><span class="fc4 sc0">:</span></div><div class="t m65 x55 h6c yc8 ff9 fs68 fc4 sc0 ls27"><span class="fc4 sc0">|</span></div><div class="t m66 x56 h6d yc9 ff9 fs69 fc4 sc0 ls27"><span class="fc4 sc0">|</span></div><div class="t m67 x42 h6e yca ff8 fs6a fc4 sc0 ls27"><span class="fc4 sc0">o</span></div><div class="t m68 x3d h6f ycb ff8 fs6b fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m69 x3e h70 ycc ff8 fs6c fc4 sc0 ls4a ws2a"><span class="fc4 sc0">In</span><span class="fc4 sc0">i</span><span class="fc4 sc0">ci</span><span class="fc4 sc0">o</span></div><div class="t m6a x44 h71 ycd ff8 fs6d fc4 sc0 ls4b"><span class="fc4 sc0">Medula</span></div><div class="t m6b x42 h72 yce ff8 fs6e fc4 sc0 ls27"><span class="fc4 sc0">E</span></div><div class="t m6c x57 h73 ycf ff8 fs6f fc4 sc0 ls20 ws2b"><span class="fc4 sc0">supr</span><span class="fc4 sc0">a</span></div><div class="t m6d x58 h74 yd0 ff8 fs70 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m6e x59 h75 yd1 ff8 fs71 fc4 sc0 ls21 ws2c"><span class="fc4 sc0">r</span><span class="fc4 sc0">enal</span></div><div class="t m6f x42 h76 yd2 ff8 fs72 fc4 sc0 ls27"><span class="fc4 sc0">¥</span></div><div class="t m70 x5a h77 yd3 ff8 fs73 fc4 sc0 ls27"><span class="fc4 sc0">e</span></div><div class="t m71 x5b h78 yd4 ff8 fs74 fc4 sc0 ls4c"><span class="fc4 sc0">ir</span></div><div class="t m72 x5c h79 yd5 ff8 fs75 fc4 sc0 ls27"><span class="fc4 sc0">/</span></div><div class="t m73 x4e h7a yd6 ff8 fs76 fc4 sc0 ls4d ws2d"><span class="fc4 sc0">AC</span><span class="fc4 sc0">H</span></div><div class="t m74 x3e h7b yd7 ff8 fs77 fc4 sc0 ls4e ws2e"><span class="fc4 sc0">AC</span><span class="fc4 sc0">H</span></div><div class="t m75 x3f h7c yd8 ff8 fs78 fc4 sc0 ls22 ws2f"><span class="fc4 sc0">Glân</span><span class="fc4 sc0">d</span><span class="fc4 sc0">ulas</span></div><div class="t m76 x47 h7d yd9 ff8 fs79 fc4 sc0 ls23 ws30"><span class="fc4 sc0">sis</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ema</span></div><div class="t m77 x22 h7e yda ff8 fs7a fc4 sc0 ls27"><span class="fc4 sc0">e</span></div><div class="t m78 x3d h7f ydb ff8 fs7b fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m79 x4e h80 ydc ff8 fs7c fc4 sc0 ls27"><span class="fc4 sc0">(</span></div><div class="t m7a x5d h81 ydd ff8 fs7d fc4 sc0 ls4f"><span class="fc4 sc0">nic</span></div><div class="t m7b x5e h82 yde ff8 fs7e fc4 sc0 ls27"><span class="fc4 sc0">)</span></div><div class="t m7c x4f h83 ydf ff8 fs7f fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m7d x52 h84 ye0 ff8 fs80 fc4 sc0 ls27"><span class="fc4 sc0">(</span></div><div class="t m7e x3e h85 ye1 ff8 fs81 fc4 sc0 ls50"><span class="fc4 sc0">mus</span></div><div class="t m7f x5f h86 ye2 ff8 fs82 fc4 sc0 ls27"><span class="fc4 sc0">)</span></div><div class="t m80 x3f h87 ye3 ff8 fs83 fc4 sc0 ls24 ws31"><span class="fc4 sc0">sa</span><span class="fc4 sc0">liv</span><span class="fc4 sc0">a</span><span class="fc4 sc0">r</span><span class="fc4 sc0">es</span></div><div class="t m81 x1e h88 ye4 ff8 fs84 fc4 sc0 ls27"><span class="fc4 sc0">}</span></div><div class="t m82 x40 h89 ye5 ff8 fs85 fc4 sc0 ls25 ws32"><span class="fc4 sc0">pa</span><span class="fc4 sc0">r</span><span class="fc4 sc0">a</span><span class="fc4 sc0">s</span><span class="fc4 sc0">simpá</span><span class="fc4 sc0">tic</span><span class="fc4 sc0">o</span></div><div class="t m83 x51 h8a ye6 ff8 fs86 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m84 x11 h8b ye7 ff8 fs87 fc4 sc0 ls26 ws33"><span class="fc4 sc0">et</span><span class="fc4 sc0">c</span></div><div class="t m85 x45 h8c ye8 ff8 fs88 fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t m86 x60 h8d ye9 ff8 fs89 fc4 sc0 ls27"><span class="fc4 sc0">/</span></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/78a32ff7-a307-4973-9e48-7514d08126ef/bg2.png"><div class="t m0 x61 h4 yea ff1 fs2 fc2 sc0 ls27 ws34">R<span class="blank _1"></span>eversão do bloqueio</div><div class="t m0 x5 h3 yeb ff2 fs1 fc1 sc0 ls0 ws34">#1. <span class="blank _0"></span>Administração de agonistas colinérgicos indiretos: <span class="ff3 ls27 ws0">neostigmina</span><span class="ls27"> </span></div><div class="t m0 x5 h3 yec ff2 fs1 fc1 sc0 ls0 ws34">- Bastante segura para não despolarizantes </div><div class="t m0 x5 h3 yed ff2 fs1 fc1 sc0 ls0 ws34">- Utilizada para fase II da succinilcolina; nunca para fase I</div><div class="t m0 x5 h5 yee ff2 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ls0 ws4">Inibição</span><span class="ls0"> da acetilcolinesterase</span><span class="ff5">: </span><span class="ls0">acetilcolina terá sua degradação diminuída, </span></div><div class="t m0 x5 h3 yef ff2 fs1 fc1 sc0 ls0 ws34">aumentando sua concentração na fenda sináptica<span class="ff5 ls27">; <span class="ff2">isso permite uma maior </span></span></div><div class="t m0 x5 h3 yf0 ff2 fs1 fc1 sc0 ls0 ws34">ocupação de receptores e impede a ligação do bloqueador neuromuscular<span class="ff5 ls27">.</span></div><div class="t m0 x5 h5 yf1 ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff6 ws3">Essa</span> <span class="ff6 ws3">ação</span> <span class="ff6 ws3">ocorrerá</span> <span class="ff6 ls0 ws4">em</span> <span class="ff6 ls28 ws35">todos</span> <span class="ff6 ls0 ws4">os</span><span class="ls51"> </span><span class="ff6 ws3">receptores</span><span class="ls51"> </span><span class="ff7">\u2192 <span class="ff6 ls0 ws4">efeitos</span></span><span class="ls51"> </span><span class="ff6 ws3">adversos</span></div><div class="t m0 x5 h3 yf2 ff2 fs1 fc1 sc0 ls0 ws34">#2. <span class="blank _0"></span>Administração de <span class="ff3">sugammadex</span></div><div class="t m0 x5 h3 yf3 ff2 fs1 fc1 sc0 ls0 ws34">- Fármaco barato e efetivo (ainda sob patente)</div><div class="t m0 x5 h3 yf4 ff2 fs1 fc1 sc0 ls0 ws34">- Molécula que se liga ao NMBA<span class="blank _0"></span> (antagonista neuromuscular), que se liga ao </div><div class="t m0 x5 h3 yf5 ff2 fs1 fc1 sc0 ls0 ws34">bloqueador neuromuscular<span class="blank _0"></span>, recolhendo esses bloqueadores do organismo, </div><div class="t m0 x5 h3 yf6 ff2 fs1 fc1 sc0 ls0 ws34">permitindo que a <span class="blank _0"></span>ACh volte a atuar</div><div class="t m0 x5 h3 yf7 ff2 fs1 fc1 sc0 ls0 ws34">- Diminui a incidência de eventos adversos (baixa toxicidade)</div><div class="t m0 x62 h3 yf8 ff2 fs1 fc1 sc0 ls0 ws34">Importância: possibilitar a recuperação </div><div class="t m0 x62 h3 yf9 ff2 fs1 fc1 sc0 ls0 ws34">dos movimentos do paciente, inclusive </div><div class="t m0 x62 h3 yfa ff2 fs1 fc1 sc0 ls0 ws34">a fala e a respiração </div><div class="t m0 x63 h4 yfb ff1 fs2 fc2 sc0 ls27 ws34">Efeitos farmacológicos da nicotina</div><div class="t m0 x39 h5 yfc ff6 fs1 fc1 sc0 ls27 ws3">A<span class="ff5 ls51 ws34"> </span><span class="ls0 ws4">nicotina<span class="ff5 ls51 ws34"> </span><span class="ls2">m</span></span><span class="ff2 ws34">imetiza as ações da <span class="blank _0"></span>A<span class="ff6 ls0 ws4">Ch</span> em receptores nicotínicos (gânglios):</span></div><div class="t m0 x39 h3 yfd ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Coração (efeitos simpáticos alternados com parassimpáticos)</span></div><div class="t m0 x39 h3 yfe ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0 ws1">Hipertensão</span></div><div class="t m0 x39 h3 yff ff5 fs1 fc1 sc0 ls27 ws34">- <span class="ff2 ls0">Bloqueio nervoso por dessensibilização</span></div><div class="t m0 x39 h3 y100 ff2 fs1 fc1 sc0 ls27 ws34">Estimula receptores N /(células cromafins) e receptores Nm na placa terminal </div><div class="t m0 x39 h3 y101 ff3 fs1 fc1 sc0 ls0 ws1">Cigarro<span class="ff2 ws34">: causa estado de alerta inicial seguido de depressão</span></div><div class="t m0 x39 h3 y102 ff2 fs1 fc1 sc0 ls0 ws34">- Superdosagem: 10-30 cigarros em pessoa não fumante <span class="ff7 ls27">\u2192 <span class="ff2">convulsão, coma e morte</span></span></div><div class="t m0 x39 h3 y103 ff2 fs1 fc1 sc0 ls0 ws34">- Dependência: memória associativa no sistema recompensa relacionado à fuga (nesse caso, do </div><div class="t m0 x39 h3 y104 ff2 fs1 fc1 sc0 ls27 ws34">relaxamento, calma que o ato de fumar traz) de situações de estresse</div><div class="t m0 x39 h3 y105 ff2 fs1 fc1 sc0 ls0 ws34">- Downregulation/infrarregulação/internalização de receptores: quanto maior o uso de nicotina, maior </div><div class="t m0 x39 h3 y106 ff2 fs1 fc1 sc0 ls0 ws34">dessensibilização dos receptores, levando à internalização dos receptores </div><div class="t m0 x39 h3 y107 ff2 fs1 fc1 sc0 ls0 ws34">- Fumar um cigarro atrás do outro: infraregulação tão grande de receptores que o efeito da nicotina é </div><div class="t m0 x39 h3 y108 ff2 fs1 fc1 sc0 ls0 ws34">muito passageiro e insuficiente, precisa manter a nicotina em altas doses para o organismo entender </div><div class="t m0 x39 h3 y109 ff2 fs1 fc1 sc0 ls0 ws34">que está tudo bem </div><div class="t m0 x39 h3 y10a ff3 fs1 fc1 sc0 ls0 ws1">Farmacocinética<span class="ff2 ls27">:</span></div><div class="t m0 x39 h3 y10b ff2 fs1 fc1 sc0 ls0 ws34">- <span class="blank _0"></span>Absorção de aproximadamente 0,5-3 mg/cigarro </div><div class="t m0 x39 h3 y10c ff2 fs1 fc1 sc0 ls0 ws34">- 80 a 90% metabolizada no fígado, mas também nos rins e pulmões <span class="ffe ls27">\u2192</span> meia vida: 1,5 a 2h </div><div class="t m0 x64 h8e y10d ff1 fs3 fc3 sc0 ls27 ws34">Efeitos colaterais </div><div class="t m0 x65 h3 y10e ff3 fs1 fc1 sc0 ls0 ws34">Interações medicamentosas<span class="ff5 ls27">: <span class="ff2">podem ocorrer com anestésicos e </span></span></div><div class="t m0 x65 h3 y10f ff2 fs1 fc1 sc0 ls0 ws34">antibióticos, potencializando os efeitos desses fármacos<span class="ff5 ls27">.</span></div><div class="t m0 x66 h3 y110 ff2 fs1 fc1 sc0 ls0 ws1">hipotensão<span class="ff5 ls27 ws34"> (</span>tubocurarina<span class="ff5 ls27 ws34">) <span class="blank _6"> </span></span><span class="v2">taquicardia</span></div><div class="t m0 x46 h3 y111 ff2 fs1 fc1 sc0 ls27 ws0">arritmia</div><div class="t m0 x67 h3 y112 ff2 fs1 fc1 sc0 ls0 ws1">bradicardia</div><div class="t m0 x68 h3 y113 ff2 fs1 fc1 sc0 ls27 ws34">dor muscular </div><div class="t m0 x67 h3 y114 ff2 fs1 fc1 sc0 ls0 ws34">elevação da </div><div class="t m0 x69 h3 y115 ff2 fs1 fc1 sc0 ls0 ws34">pressão intra-ocular </div><div class="t m0 x3d h3 y116 ff2 fs1 fc1 sc0 ls0 ws1">(succinilcolina)</div><div class="t m0 x45 h3 y117 ff2 fs1 fc1 sc0 ls0 ws34">hipercalemia: </div><div class="t m0 x59 h3 y118 ff2 fs1 fc1 sc0 ls0 ws34">geralmente, em </div><div class="t m0 x6a h3 y119 ff2 fs1 fc1 sc0 ls27 ws34">pacientes com </div><div class="t m0 x45 h3 y11a ff2 fs1 fc1 sc0 ls27 ws34">traumatismos </div><div class="t m0 x59 h3 y11b ff2 fs1 fc1 sc0 ls0 ws1">(succinilcolina)</div><div class="t m0 x6b h3 y11c ff2 fs1 fc1 sc0 ls0 ws34">hipertermia maligna: </div><div class="t m0 x6c h3 y11d ff2 fs1 fc1 sc0 ls27 ws34">pacientes com </div><div class="t m0 x6d h3 y11e ff2 fs1 fc1 sc0 ls0 ws34">predisposição </div><div class="t m0 x50 h3 y11f ff2 fs1 fc1 sc0 ls0 ws34">genética </div><div class="t m0 x6c h3 y120 ff2 fs1 fc1 sc0 ls0 ws1">(succinilcolina)</div><div class="t m0 x6e h5 y121 ff2 fs1 fc1 sc0 ls27 ws34">Pessoa estressad<span class="ff6 ls52">a</span><span class="ff5">/</span></div><div class="t m0 x6e h5 y122 ff6 fs1 fc1 sc0 ls0 ws4">pós<span class="ff5 ls27 ws34"> </span>atividade<span class="ff5 ls27 ws34"> <span class="ff6 ws3">física</span>: </span></div><div class="t m0 x29 h5 y123 ff6 fs1 fc1 sc0 ls0 ws4">prevalece<span class="ff2 ls27 ws34"> reação </span></div><div class="t m0 x6f h3 y124 ff2 fs1 fc1 sc0 ls27 ws34">simpática (contração </div><div class="t m0 x6f h5 y125 ff2 fs1 fc1 sc0 ls27 ws34">muscular<span class="blank _0"></span>, <span class="ff6 ws3">sudorese</span>). </div><div class="t m0 x6f h3 y126 ff2 fs1 fc1 sc0 ls27 ws34">Ao fumar um cigarro<span class="ff5">, </span></div><div class="t m0 x70 h5 y127 ff6 fs1 fc1 sc0 ls5">a<span class="ff5 ls27 ws34"> </span><span class="ls0 ws4">nicotina</span><span class="ff5 ls53 ws34"> </span><span class="ls28 ws35">faz</span><span class="ff5 ls27 ws34"> </span><span class="ls27 ws3">uma<span class="ff5 ws34"> </span></span></div><div class="t m0 x6f h3 y128 ff2 fs1 fc1 sc0 ls0 ws34">inversão autonômica<span class="ff5 ls27"> </span></div><div class="t m0 x70 h5 y129 ff5 fs1 fc1 sc0 ls27 ws0">(<span class="ff6 ls0 ws4">redução<span class="ff2 ls28 ws34"> do efeito </span></span></div><div class="t m0 x70 h3 y12a ff2 fs1 fc1 sc0 ls0 ws34">simpático) seguida </div><div class="t m0 x6f h3 y12b ff2 fs1 fc1 sc0 ls0 ws34">de dessensibilização<span class="ff5 ls27"> </span></div><div class="t m0 x33 h5 y12c ff6 fs1 fc1 sc0 ls0 ws4">dos<span class="ff5 ls27 ws34"> <span class="ff6 ws3">receptores</span> </span></div><div class="t m0 x2a h5 y12d ff6 fs1 fc1 sc0 ls0 ws4">nicotínicos<span class="ff5 ls27 ws34"> </span></div><div class="t m0 x6f h5 y12e ff6 fs1 fc1 sc0 ls27 ws3">simpáticos<span class="ff5 ws34">, </span><span class="ls5">o<span class="ff5 ls53 ws34"> </span><span class="ls0 ws4">que</span></span><span class="ff5 ws34"> </span><span class="ls0 ws4">dá</span><span class="ff5 ws34"> </span></div><div class="t m0 x70 h5 y12f ff6 fs1 fc1 sc0 ls27 ws3">uma<span class="ff5 ws34"> </span>sensação<span class="ff5 ws34"> </span><span class="ls0 ws4">de</span><span class="ff5 ws34"> </span></div><div class="t m0 x71 h5 y130 ff6 fs1 fc1 sc0 ls0 ws4">tranquilidade<span class="ff5 ls27">.</span></div><div class="t m0 x72 h3 y131 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">M</span><span class="fc4 sc0">or</span><span class="fc4 sc0">t</span><span class="fc4 sc0">e </span><span class="fc4 sc0">por</span><span class="fc4 sc0"> </span><span class="fc4 sc0">dos</span><span class="fc4 sc0">e </span><span class="fc4 sc0">ex</span><span class="fc4 sc0">c</span><span class="fc4 sc0">es</span><span class="fc4 sc0">s</span><span class="fc4 sc0">iv</span><span class="fc4 sc0">a </span><span class="fc4 sc0">de </span><span class="fc4 sc0">nic</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">ina </span><span class="ffe ls27"><span class="fc4 sc0">\u2192</span></span><span class="fc4 sc0"> </span><span class="fc4 sc0">c</span><span class="fc4 sc0">onv</span><span class="fc4 sc0">uls</span><span class="fc4 sc0">ão </span><span class="fc4 sc0">dec</span><span class="fc4 sc0">or</span><span class="fc4 sc0">r</span><span class="fc4 sc0">ida </span><span class="fc4 sc0">de </span><span class="fc4 sc0">aum</span><span class="fc4 sc0">ent</span><span class="fc4 sc0">o </span><span class="fc4 sc0">de </span><span class="fc4 sc0">s</span><span class="fc4 sc0">ec</span><span class="fc4 sc0">r</span><span class="fc4 sc0">eç</span><span class="fc4 sc0">ão </span><span class="fc4 sc0">no </span><span class="fc4 sc0">pulm</span><span class="fc4 sc0">ão,</span><span class="fc4 sc0"> </span></div><div class="t m0 x73 h3 y132 ff2 fs1 fc1 sc0 ls0 ws34"><span class="fc4 sc0">t</span><span class="fc4 sc0">aquic</span><span class="fc4 sc0">ar</span><span class="fc4 sc0">dia,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">ent</span><span class="fc4 sc0">r</span><span class="fc4 sc0">e </span><span class="fc4 sc0">out</span><span class="fc4 sc0">r</span><span class="fc4 sc0">os</span><span class="fc4 sc0"> </span><span class="fc4 sc0">s</span><span class="fc4 sc0">int</span><span class="fc4 sc0">om</span><span class="fc4 sc0">as</span><span class="fc4 sc0">,</span><span class="fc4 sc0"> </span><span class="fc4 sc0">que </span><span class="fc4 sc0">oc</span><span class="fc4 sc0">or</span><span class="fc4 sc0">r</span><span class="fc4 sc0">em</span><span class="fc4 sc0"> </span><span class="fc4 sc0">dev</span><span class="fc4 sc0">ido </span><span class="fc4 sc0">a </span><span class="fc4 sc0">um</span><span class="fc4 sc0">a </span><span class="fc4 sc0">alt</span><span class="fc4 sc0">a </span><span class="fc4 sc0">des</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ar</span><span class="fc4 sc0">ga </span><span class="fc4 sc0">de </span><span class="fc4 sc0">nic</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">ina.</span><span class="fc4 sc0"> </span></div><div class="t m87 x3e h8f y133 ff8 fs8a fc4 sc0 ls27"><span class="fc4 sc0">^</span></div><div class="t m88 x74 h90 y134 ff9 fs8b fc4 sc0 ls27"><span class="fc4 sc0">\</span></div><div class="t m89 x3e h91 y135 ff8 fs8c fc4 sc0 ls27"><span class="fc4 sc0">1</span></div><div class="t m8a x3f h92 y136 ff9 fs8d fc4 sc0 ls27"><span class="fc4 sc0">o</span></div><div class="t m8b x5e h93 y137 ff8 fs8e fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m8c x75 h94 y138 ff8 fs8f fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m8d x76 h95 y139 fff fs90 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m8e x77 h96 y13a ff8 fs91 fc4 sc0 ls27"><span class="fc4 sc0">!</span></div><div class="t m8f x78 h97 y13b ff8 fs92 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m90 x79 h98 y13c ff9 fs93 fc4 sc0 ls27"><span class="fc4 sc0">(</span></div><div class="t m91 x7a h99 y13d ff9 fs94 fc4 sc0 ls66"><span class="fc4 sc0">iiiiiiiiiiii</span></div><div class="t m92 x7b h9a y13e ff9 fs95 fc4 sc0 ls67"><span class="fc4 sc0">.ir?::::i:ini:::::::i</span></div><div class="t m93 x7c h9b y13f ff9 fs96 fc4 sc0 ls27"><span class="fc4 sc0">:</span></div><div class="t m94 x4c h9c y140 ff9 fs97 fc4 sc0 ls68"><span class="fc4 sc0">:*</span></div><div class="t m95 x7d h9d y141 ff8 fs98 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t m96 x7e h9e y142 ff8 fs99 fc4 sc0 ls69 ws36"><span class="fc4 sc0">car</span><span class="fc4 sc0">ot</span><span class="fc4 sc0">í</span><span class="fc4 sc0">d</span><span class="fc4 sc0">e</span><span class="fc4 sc0">o</span></div><div class="t m97 x7f h9f y143 ff8 fs9a fc4 sc0 ls27"><span class="fc4 sc0">e</span></div><div class="t m98 x80 ha0 y144 ff8 fs9b fc4 sc0 ls54 ws37"><span class="fc4 sc0">aór</span><span class="fc4 sc0">t</span><span class="fc4 sc0">icos</span></div><div class="t m99 x7a ha1 y145 ff8 fs9c fc4 sc0 ls6a ws38"><span class="fc4 sc0">Re</span><span class="fc4 sc0">s</span><span class="fc4 sc0">p</span><span class="blank"> </span><span class="fc4 sc0">i</span><span class="blank"> </span><span class="fc4 sc0">r</span><span class="blank"> </span><span class="fc4 sc0">a</span><span class="blank"> </span><span class="fc4 sc0">t</span><span class="blank"> </span><span class="fc4 sc0">ó</span><span class="blank"> </span><span class="fc4 sc0">r</span><span class="blank"> </span><span class="fc4 sc0">i</span><span class="blank"> </span><span class="fc4 sc0">o</span></div><div class="t m9a x81 ha2 y146 ff8 fs9d fc4 sc0 ls55 ws39"><span class="fc4 sc0">pf</span><span class="fc4 sc0">r</span></div><div class="t m9b x82 ha3 y147 ff8 fs9e fc4 sc0 ls56 ws3a"><span class="fc4 sc0">Es</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ímulos</span></div><div class="t m9c x7f ha4 y148 ff8 fs9f fc4 sc0 ls6b"><span class="fc4 sc0">de</span></div><div class="t m9d x48 ha5 y149 ff8 fsa0 fc4 sc0 ls6c ws3b"><span class="fc4 sc0">ce</span><span class="fc4 sc0">n</span><span class="fc4 sc0">t</span><span class="fc4 sc0">r</span><span class="fc4 sc0">os</span></div><div class="t m9e x83 ha6 y14a ff8 fsa1 fc4 sc0 ls27"><span class="fc4 sc0">+</span></div><div class="t m9f x84 ha7 y14b ff8 fsa2 fc4 sc0 ls6d"><span class="fc4 sc0">FR</span></div><div class="t ma0 x16 ha8 y14c ff8 fsa3 fc4 sc0 ls57 ws3c"><span class="fc4 sc0">D</span><span class="fc4 sc0">es</span><span class="fc4 sc0">sensibil</span><span class="fc4 sc0">iza</span><span class="fc4 sc0">ç</span><span class="fc4 sc0">ã</span><span class="fc4 sc0">o</span></div><div class="t ma1 x85 ha9 y14d ff8 fsa4 fc4 sc0 ls6e ws3d"><span class="fc4 sc0">AC</span><span class="fc4 sc0">H</span><span class="blank"> </span><span class="fc4 sc0">E</span></div><div class="t ma2 x86 haa y14e ff8 fsa5 fc4 sc0 ls58 ws3e"><span class="fc4 sc0">r</span><span class="fc4 sc0">espirat</span><span class="fc4 sc0">órios</span></div><div class="t ma3 x80 hab y14f ff8 fsa6 fc4 sc0 ls6f"><span class="fc4 sc0">no</span></div><div class="t ma4 x87 hac y150 ff8 fsa7 fc4 sc0 ls70"><span class="fc4 sc0">SNC</span></div><div class="t ma5 x88 had y151 ff8 fsa8 fc4 sc0 ls71"><span class="fc4 sc0">dos</span></div><div class="t ma6 x4a hae y152 ff8 fsa9 fc4 sc0 ls72 ws3f"><span class="fc4 sc0">re</span><span class="fc4 sc0">c</span><span class="fc4 sc0">e</span><span class="fc4 sc0">p</span><span class="fc4 sc0">t</span><span class="fc4 sc0">o</span><span class="blank"> </span><span class="fc4 sc0">re</span><span class="blank"> </span><span class="fc4 sc0">s</span></div><div class="t ma7 x89 haf y153 ff8 fsaa fc4 sc0 ls73"><span class="fc4 sc0">no</span></div><div class="t ma8 x8a hb0 y154 ff8 fsab fc4 sc0 ls74"><span class="fc4 sc0">SNC</span></div><div class="t ma9 x8b hb1 y155 ff9 fsac fc4 sc0 ls27"><span class="fc4 sc0">÷</span></div><div class="t maa x8c hb2 y156 ff9 fsad fc4 sc0 ls75 ws40"><span class="fc4 sc0">;÷</span><span class="fc4 sc0">§</span><span class="fc4 sc0">p</span><span class="ffa"><span class="fc4 sc0">µ</span></span></div><div class="t mab x77 hb3 y157 ff8 fsae fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mac x53 hb4 y158 ffa fsaf fc4 sc0 ls27"><span class="fc4 sc0">µ</span></div><div class="t mad x8d hb5 y159 ff8 fsb0 fc4 sc0 ls27"><span class="fc4 sc0">,</span></div><div class="t mae x72 hb6 y15a ff10 fsb1 fc4 sc0 ls27"><span class="fc4 sc0">\udb8b\udc1b</span></div><div class="t maf x10 hb7 y15b ff8 fsb2 fc4 sc0 ls27"><span class="fc4 sc0">*</span></div><div class="t mb0 xb hb8 y15c ff8 fsb3 fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mb1 x6 hb9 y15d ff8 fsb4 fc4 sc0 ls27"><span class="fc4 sc0">÷</span></div><div class="t mb2 x8e hba y15e ff8 fsb5 fc4 sc0 ls76 ws41"><span class="fc4 sc0">:÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span></div><div class="t mb3 xa hbb y15f ff8 fsb6 fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mb4 x86 hbc y160 ff8 fsb7 fc4 sc0 ls77 ws42"><span class="fc4 sc0">;÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span></div><div class="t mb5 x14 hbd y161 ff8 fsb8 fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mb6 x13 hbe y162 ff8 fsb9 fc4 sc0 ls27"><span class="fc4 sc0">+</span></div><div class="t mb7 x8f hbf y163 ff8 fsba fc4 sc0 ls27"><span class="fc4 sc0">*</span></div><div class="t mb8 x15 hc0 y164 ff8 fsbb fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mb9 x49 hc1 y165 ff8 fsbc fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mba x90 hc2 y166 ff8 fsbd fc4 sc0 ls78 ws43"><span class="fc4 sc0">?÷</span><span class="fc4 sc0">ç÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span><span class="fc4 sc0">÷</span></div><div class="t mbb x91 hc3 y167 ff9 fsbe fc4 sc0 ls79"><span class="fc4 sc0">:*</span></div><div class="t mbc x92 hc4 y168 ff9 fsbf fc4 sc0 ls7a"><span class="fc4 sc0">:{</span></div><div class="t mbd x93 hc5 y169 ff8 fsc0 fc4 sc0 ls27"><span class="fc4 sc0">÷</span></div><div class="t mbe x94 hc6 y16a ff8 fsc1 fc4 sc0 ls27"><span class="fc4 sc0">.</span></div><div class="t mbf x7d hc7 y16b ff8 fsc2 fc4 sc0 ls27"><span class="fc4 sc0">)</span></div><div class="t mc0 x95 hc8 y16c ff8 fsc3 fc4 sc0 ls27"><span class="fc4 sc0">|</span></div><div class="t mc1 x96 hc9 y16d ff8 fsc4 fc4 sc0 ls59 ws44"><span class="fc4 sc0">Es</span><span class="fc4 sc0">t</span><span class="fc4 sc0">ímulo</span></div><div class="t mc2 x97 hca y16e ff8 fsc5 fc4 sc0 ls7b"><span class="fc4 sc0">de</span></div><div class="t mc3 x7f hcb y16f ff8 fsc6 fc4 sc0 ls7c ws45"><span class="fc4 sc0">no</span><span class="fc4 sc0">c</span><span class="fc4 sc0">ic</span><span class="fc4 sc0">ept</span><span class="fc4 sc0">o</span><span class="fc4 sc0">r</span><span class="fc4 sc0">es</span></div><div class="t mc4 x98 hcc y170 ff8 fsc7 fc4 sc0 ls5a ws46"><span class="fc4 sc0">D</span><span class="fc4 sc0">es</span><span class="fc4 sc0">sensibil</span><span class="fc4 sc0">iza</span><span class="fc4 sc0">ç</span><span class="fc4 sc0">ã</span><span class="fc4 sc0">o</span></div><div class="t mc5 x99 hcd y171 ff8 fsc8 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t mc6 x60 hce y172 ff8 fsc9 fc4 sc0 ls7d ws47"><span class="fc4 sc0">Pe</span><span class="fc4 sc0">l</span><span class="fc4 sc0">e</span></div><div class="t mc7 x8e hcf y173 ff8 fsca fc4 sc0 ls7e ws48"><span class="fc4 sc0">ts</span><span class="fc4 sc0">u</span><span class="fc4 sc0">d</span><span class="fc4 sc0">o</span><span class="fc4 sc0">r</span><span class="fc4 sc0">e</span><span class="fc4 sc0">s</span><span class="fc4 sc0">e</span></div><div class="t mc8 x96 hd0 y174 ff8 fscb fc4 sc0 ls7f ws49"><span class="fc4 sc0">At</span><span class="fc4 sc0">i</span><span class="blank"> </span><span class="fc4 sc0">v</span><span class="fc4 sc0">a</span><span class="blank"> </span><span class="fc4 sc0">ç</span><span class="blank"> </span><span class="fc4 sc0">ã</span><span class="blank"> </span><span class="fc4 sc0">o</span></div><div class="t mc9 x97 hd1 y175 ff8 fscc fc4 sc0 ls80"><span class="fc4 sc0">de</span></div><div class="t mca x9a hd2 y176 ff8 fscd fc4 sc0 ls5b ws4a"><span class="fc4 sc0">gâ</span><span class="fc4 sc0">ngl</span><span class="fc4 sc0">io</span><span class="fc4 sc0">s</span></div><div class="t mcb x13 hd3 y177 ff8 fsce fc4 sc0 ls5c ws4b"><span class="fc4 sc0">lvtudor</span><span class="fc4 sc0">es</span><span class="fc4 sc0">e</span></div><div class="t mcc x9b hd4 y178 ff8 fscf fc4 sc0 ls5d ws4c"><span class="fc4 sc0">simpá</span><span class="fc4 sc0">tic</span><span class="fc4 sc0">a</span></div><div class="t mcd x9c hd5 y179 ff8 fsd0 fc4 sc0 ls27"><span class="fc4 sc0">e</span></div><div class="t mce x92 hd6 y17a ff8 fsd1 fc4 sc0 ls5e ws4d"><span class="fc4 sc0">da</span><span class="fc4 sc0">s</span></div><div class="t mcf x53 hd7 y17b ff8 fsd2 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t md0 x4d hd8 y17c ff8 fsd3 fc4 sc0 ls5f ws4e"><span class="fc4 sc0">simpá</span><span class="fc4 sc0">tic</span><span class="fc4 sc0">o</span><span class="fc4 sc0">s</span></div><div class="t md1 xe hd9 y17d ff8 fsd4 fc4 sc0 ls60 ws4f"><span class="fc4 sc0">t</span><span class="fc4 sc0">er</span><span class="fc4 sc0">min</span><span class="fc4 sc0">ações</span></div><div class="t md2 x9d hda y17e ff8 fsd5 fc4 sc0 ls61 ws50"><span class="fc4 sc0">senso</span><span class="fc4 sc0">r</span><span class="fc4 sc0">ia</span><span class="fc4 sc0">is</span></div><div class="t md3 x11 hdb y17f ff8 fsd6 fc4 sc0 ls81 ws51"><span class="fc4 sc0">Suga</span><span class="fc4 sc0">mma</span><span class="fc4 sc0">de</span><span class="fc4 sc0">x</span></div><div class="t md4 x9e hdc y180 ff8 fsd7 fc4 sc0 ls62 ws52"><span class="fc4 sc0">NA</span><span class="fc4 sc0">CHR</span></div><div class="t md5 x9f hdd y181 ff9 fsd8 fc4 sc0 ls27"><span class="fc4 sc0">[</span></div><div class="t md6 x72 hde y182 ff9 fsd9 fc4 sc0 ls27"><span class="fc4 sc0">{</span></div><div class="t md7 x51 hdf y183 ff8 fsda fc4 sc0 ls27 ws53"><span class="fc4 sc0">E</span><span class="fc4 sc0">lé</span><span class="fc4 sc0">t</span><span class="fc4 sc0">r</span><span class="fc4 sc0">i</span><span class="fc4 sc0">c</span><span class="fc4 sc0">a</span></div><div class="t md8 xa0 he0 y184 ff8 fsdb fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t md9 x9a he1 y185 ff8 fsdc fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t mda x12 he2 y186 ff8 fsdd fc4 sc0 ls63 ws54"><span class="fc4 sc0">fraq</span><span class="fc4 sc0">ue</span><span class="fc4 sc0">za</span></div><div class="t mdb x49 he3 y187 ff8 fsde fc4 sc0 ls82 ws55"><span class="fc4 sc0">le</span><span class="fc4 sc0">v</span><span class="fc4 sc0">e</span></div><div class="t ma0 x88 ha8 y188 ff8 fsa3 fc4 sc0 ls57 ws3c"><span class="fc4 sc0">D</span><span class="fc4 sc0">es</span><span class="fc4 sc0">sensibil</span><span class="fc4 sc0">iza</span><span class="fc4 sc0">ç</span><span class="fc4 sc0">ã</span><span class="fc4 sc0">o</span></div><div class="t mdc x56 he4 y189 ff8 fsdf fc4 sc0 ls83 ws56"><span class="fc4 sc0">le</span><span class="fc4 sc0">v</span><span class="fc4 sc0">e</span></div><div class="t mdd xa1 he5 y18a ff8 fse0 fc4 sc0 ls64 ws57"><span class="fc4 sc0">t</span><span class="fc4 sc0">emporária</span></div><div class="t mde x98 he6 y18b ff8 fse1 fc4 sc0 ls65 ws58"><span class="fc4 sc0">do</span><span class="fc4 sc0">s</span></div><div class="t mdf xa2 he7 y18c ff8 fse2 fc4 sc0 ls84 ws59"><span class="fc4 sc0">re</span><span class="fc4 sc0">c</span><span class="fc4 sc0">e</span><span class="fc4 sc0">p</span><span class="fc4 sc0">t</span><span class="blank"> </span><span class="fc4 sc0">o</span><span class="blank"> </span><span class="fc4 sc0">re</span><span class="blank"> </span><span class="fc4 sc0">s</span></div><div class="t me0 xa3 he8 y18d ff8 fse3 fc4 sc0 ls85"><span class="fc4 sc0">Nm</span></div><div class="t me1 xa4 he9 y18e ff8 fse4 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div><div class="t me2 x7d hea y18f ff8 fse5 fc4 sc0 ls27"><span class="fc4 sc0">-</span></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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