<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg1.png"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls0 ws0">Apopt<span class="blank _0"></span>ose</div><div class="t m1 x2 h3 y2 ff2 fs1 fc0 sc0 ls2">e</div><div class="t m2 x3 h4 y3 ff3 fs2 fc0 sc0 ls1 ws1">Necr<span class="blank _0"></span>ose</div><div class="t m3 x4 h5 y4 ff4 fs3 fc0 sc0 ls3 ws2">Ma<span class="blank"> </span>ya<span class="blank"> </span>ra</div><div class="t m4 x5 h6 y5 ff5 fs4 fc0 sc0 ls2">M</div><div class="t m5 x6 h7 y6 ff2 fs5 fc0 sc0 ls2">.</div><div class="t m6 x7 h8 y7 ff6 fs6 fc0 sc0 ls4 ws3">dirão</div><div class="t m7 x8 h9 y8 ff7 fs7 fc0 sc0 ls5">BCM</div><div class="t m8 x9 ha y9 ff2 fs8 fc0 sc0 ls2">-</div><div class="t m9 xa hb ya ff2 fs9 fc0 sc0 ls2">A</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 hc" data-page-no="2"><div class="pc pc2 w0 hc"><img class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg2.png"><div class="t ma xb he yb ff2 fsa fc0 sc0 ls2">\u2022</div><div class="t mb xc hf yc ff8 fsb fc0 sc0 ls11 ws5">Homeostase</div><div class="t mc xd h10 yd ff9 fsc fc0 sc0 ls12">de</div><div class="t md xe h11 ye ff2 fsd fc0 sc0 ls13">um</div><div class="t me xf h12 yf ffa fse fc0 sc0 ls6 ws6">or<span class="blank _0"></span>ganismo</div><div class="t mf x10 h13 y10 ffb fsf fc0 sc0 ls14 ws7">multicelular</div><div class="t m10 x11 h14 y11 ff2 fs10 fc0 sc0 ls2">:</div><div class="t m11 xb h15 y12 ffc fs11 fc0 sc0 ls2">\u21b3</div><div class="t m12 x12 h16 y13 ffd fs12 fc0 sc0 ls15 ws8">homeostase</div><div class="t m13 x13 h17 y14 ffe fs13 fc0 sc0 ls16">são</div><div class="t m14 x14 h18 y15 ff2 fs14 fc0 sc0 ls17">as</div><div class="t m15 x15 h19 y16 fff fs15 fc0 sc0 ls18">condiçoes</div><div class="t m16 x16 h1a y17 ff10 fs16 fc0 sc0 ls19 ws9">Ótimas</div><div class="t m17 x17 h1b y18 ff11 fs17 fc0 sc0 ls1a wsa">para</div><div class="t m18 x18 h1c y19 ff2 fs18 fc0 sc0 ls1b">uma</div><div class="t m19 x19 h1d y1a ff12 fs19 fc0 sc0 ls1c wsb">célula</div><div class="t m1a xa h1e y1b ff13 fs1a fc0 sc0 ls1d wsc">trabalhar</div><div class="t m1b x1a h1f y1c ff2 fs1b fc0 sc0 ls2">,</div><div class="t m1c x1b h20 y1d ff14 fs1c fc0 sc0 ls1e wsd">hav<span class="blank _0"></span>endo</div><div class="t m1d x1c h21 y1e ff2 fs1d fc0 sc0 ls1f">um</div><div class="t m1e x1d h22 y1f ff15 fs1e fc0 sc0 ls7 wse">equilibrio</div><div class="t m1f x1e h23 y20 ff16 fs1f fc0 sc0 ls20 wsf">entre</div><div class="t m20 x1f h24 y21 ff2 fs20 fc0 sc0 ls2">a</div><div class="t m21 x3 h25 y22 ff17 fs21 fc0 sc0 ls8 ws10">pr<span class="blank _0"></span>olif<span class="blank _1"></span>eração</div><div class="t m22 x4 h26 y23 ff18 fs22 fc0 sc0 ls21 ws11">celular</div><div class="t m23 x20 h27 y24 ff2 fs23 fc0 sc0 ls2">,</div><div class="t m24 x21 h28 y25 ff19 fs24 fc0 sc0 ls22 ws12">necessária</div><div class="t m25 x22 h29 y26 ff1a fs25 fc0 sc0 ls23 ws13">para</div><div class="t m26 x0 h2a y27 ff1b fs26 fc0 sc0 ls24 ws14">manter</div><div class="t m27 x23 h2b y28 ff2 fs27 fc0 sc0 ls2">o</div><div class="t m28 x24 h2c y29 ff1c fs28 fc0 sc0 ls25 ws15">tecid<span class="blank _2"> </span>o</div><div class="t m29 x25 h2d y2a ff1d fs29 fc0 sc0 ls26 ws16">viáv<span class="blank _0"></span>el</div><div class="t m2a x15 h2e y2b ff2 fs2a fc0 sc0 ls2">,</div><div class="t m2b x26 h2f y2c ff2 fs2b fc0 sc0 ls2">a</div><div class="t m2c x27 h30 y2d ff1e fs2c fc0 sc0 ls9 ws17">dif<span class="blank _1"></span>erenciação</div><div class="t m2d x28 h31 y2e ff1f fs2d fc0 sc0 ls27 ws18">celular</div><div class="t m2e x29 h32 y2f ff2 fs2e fc0 sc0 ls2">,</div><div class="t m2f x2a h33 y30 ff20 fs2f fc0 sc0 lsa ws19">ativação</div><div class="t m30 xa h34 y31 ff2 fs30 fc0 sc0 ls28">ou</div><div class="t m31 x2b h35 y32 ff2 fs31 fc0 sc0 ls29 ws1a">não</div><div class="t m32 x2c h36 y33 ff2 fs32 fc0 sc0 ls2a">de</div><div class="t m33 x2d h37 y34 ff2 fs33 fc0 sc0 ls2b">um</div><div class="t m34 x2e h38 y35 ff21 fs34 fc0 sc0 ls2c ws1b">determinado</div><div class="t m35 x2f h39 y36 ff22 fs35 fc0 sc0 ls2d ws1c">gene</div><div class="t m36 x30 h3a y37 ff2 fs36 fc0 sc0 ls2e">que</div><div class="t m37 x31 h3b y38 ff23 fs37 fc0 sc0 lsb ws1d">Ébano</div><div class="t m38 x32 h3c y39 ff2 fs38 fc0 sc0 ls2">e</div><div class="t m39 x33 h3d y3a ff24 fs39 fc0 sc0 lsc ws1e">função</div><div class="t m3a x34 h3e y3b ff25 fs3a fc0 sc0 ls2f">da</div><div class="t m3b x20 h3f y3c ff26 fs3b fc0 sc0 ls30 ws1f">célula</div><div class="t m3c x35 h40 y3d ff27 fs3c fc0 sc0 ls2">(</div><div class="t m3d x36 h41 y3e ff2 fs3d fc0 sc0 ls31">Ex</div><div class="t m3e x37 h42 y3f ff2 fs3e fc0 sc0 ls2">-</div><div class="t m3f x38 h43 y40 ff2 fs3f fc0 sc0 ls2">:</div><div class="t m40 x1b h44 y41 ff1 fs40 fc0 sc0 lsd ws20">neur<span class="blank _1"></span>ônio</div><div class="t m41 x12 h45 y42 ff2 fs41 fc0 sc0 ls2">é</div><div class="t m42 x39 h46 y43 ff28 fs42 fc0 sc0 ls32 ws21">dif<span class="blank _1"></span>erente</div><div class="t m43 x3a h47 y44 ff2 fs43 fc0 sc0 ls33">do</div><div class="t m44 x14 h48 y45 ff29 fs44 fc0 sc0 ls34 ws22">hepatócit<span class="blank _0"></span>os</div><div class="t m45 x3b h49 y46 ff2 fs45 fc0 sc0 ls2">e</div><div class="t m46 x3c h4a y47 ff2 fs46 fc0 sc0 ls2">a</div><div class="t m47 x3d h4b y48 ff2a fs47 fc0 sc0 ls35 ws23">mor<span class="blank"> </span>te</div><div class="t m48 x3e h4c y49 ff2b fs48 fc0 sc0 ls36 ws24">celular</div><div class="t m49 x34 h4d y4a ff2 fs49 fc0 sc0 ls2">,</div><div class="t m4a x3f h4e y4b ff2 fs4a fc0 sc0 ls2">o</div><div class="t m4b x19 h4f y4c ff2c fs4b fc0 sc0 ls37">fim</div><div class="t m4c x9 h50 y4d ff2 fs4c fc0 sc0 ls38">de</div><div class="t m4d x36 h51 y4e ff2 fs4d fc0 sc0 ls39 ws25">dar</div><div class="t m4e x0 h52 y4f ff2 fs4e fc0 sc0 ls3a ws26">espaço</div><div class="t m4f x40 h53 y50 ff2 fs4f fc0 sc0 ls3b ws27">para</div><div class="t m50 x41 h54 y51 ff2 fs50 fc0 sc0 ls2 ws28">nov<span class="blank _0"></span>as</div><div class="t m51 x42 h55 y52 ff2d fs51 fc0 sc0 ls3c ws29">células</div><div class="t m52 x43 h56 y53 ff2 fs52 fc0 sc0 ls2">(</div><div class="t m53 x44 h57 y54 ff2 fs53 fc0 sc0 ls3d ws2a">neurônios</div><div class="t m54 x45 h58 y55 ff2 fs54 fc0 sc0 ls3e ws2b">são</div><div class="t m55 x46 h59 y56 ff2 fs55 fc0 sc0 ls3f">as</div><div class="t m56 x4 h5a y57 ff2e fs56 fc0 sc0 ls40 ws2c">células</div><div class="t m57 x8 h5b y58 ff2 fs57 fc0 sc0 ls41">que</div><div class="t m58 x47 h5c y59 ff2 fs58 fc0 sc0 ls42 ws2d">vivem</div><div class="t m59 x22 h5d y5a ff2 fs59 fc0 sc0 ls43">mais</div><div class="t m5a x48 h5e y5b ff2 fs5a fc0 sc0 ls2">)</div><div class="t m5b x2d h5f y5c ff2 fs5b fc0 sc0 ls2">\u2022</div><div class="t m5c x49 h60 y5d ff2f fs5c fc0 sc0 ls44">Uma</div><div class="t m5d x23 h61 y5e ff30 fs5d fc0 sc0 ls45 ws2e">lesão</div><div class="t m5e x4a h62 y5f ff31 fs5e fc0 sc0 ls46 ws2f">celular</div><div class="t m5f x4b h63 y60 ff32 fs5f fc0 sc0 ls47 ws30">pode</div><div class="t m60 x4c h64 y61 ff2 fs60 fc0 sc0 ls48">ser</div><div class="t m61 x4d h65 y62 ff33 fs61 fc0 sc0 ls49 ws31">rever<span class="blank"> </span>s<span class="blank"> </span>í<span class="blank"> </span>ve<span class="blank"> </span>l</div><div class="t m62 x28 h66 y63 ff34 fs62 fc0 sc0 ls2">(</div><div class="t m63 x3e h67 y64 ff35 fs63 fc0 sc0 ls4a ws32">quando</div><div class="t m64 x3f h68 y65 ff2 fs64 fc0 sc0 ls4b">e-</div><div class="t m65 x8 h69 y66 ff36 fs65 fc0 sc0 ls4c ws33">lev<span class="blank _0"></span>e</div><div class="t m66 x9 h6a y67 ff2 fs66 fc0 sc0 ls2">e</div><div class="t m67 x4e h6b y68 ff37 fs67 fc0 sc0 ls4d ws34">transitória</div><div class="t m68 x1b h6c y69 ff2 fs68 fc0 sc0 ls4e">ou</div><div class="t m69 x4f h6d y6a ff38 fs69 fc0 sc0 ls4f ws35">irre<span class="blank _0"></span>ver<span class="blank _0"></span>sív<span class="blank _0"></span>el</div><div class="t m6a x50 h6e y6b ff39 fs6a fc0 sc0 ls2">(</div><div class="t m6b x25 h6f y6c ff3a fs6b fc0 sc0 ls50">quando</div><div class="t m6c x51 h70 y6d ff2 fs6c fc0 sc0 ls2">é</div><div class="t m6d x52 h71 y6e ff3b fs6d fc0 sc0 ls51 ws36">intensa</div><div class="t m6e x10 h72 y6f ff2 fs6e fc0 sc0 ls2">e</div><div class="t m6f x53 h73 y70 ff3c fs6f fc0 sc0 ls52 ws37">progr<span class="blank _0"></span>essiv<span class="blank _0"></span>a</div><div class="t m70 x11 h74 y71 ff3d fs70 fc0 sc0 ls2">)</div><div class="t m71 x2a h75 y72 ff2 fs71 fc0 sc0 ls2">,</div><div class="t m72 x54 h76 y73 ff3e fs72 fc0 sc0 ls53">ambas</div><div class="t m73 x55 h77 y74 ff2 fs73 fc0 sc0 ls54 ws38">são</div><div class="t m74 x56 h78 y75 ff2 fs74 fc0 sc0 ls55 ws39">causadas</div><div class="t m75 x1b h79 y76 ff2 fs75 fc0 sc0 ls56 ws3a">por</div><div class="t m76 x57 h7a y77 ff3f fs76 fc0 sc0 ls57 ws3b">estres<span class="blank _0"></span>se</div><div class="t m77 x58 h7b y78 ff2 fs77 fc0 sc0 ls2">(</div><div class="t m78 x59 h7c y79 ff2 fs78 fc0 sc0 ls58">Ex</div><div class="t m79 x5a h7d y7a ff2 fs79 fc0 sc0 ls2">-</div><div class="t m7a x13 h7e y7b ff2 fs7a fc0 sc0 ls2">:</div><div class="t m7b x5b h7f y7c ff40 fs7b fc0 sc0 ls59 ws3c">estimado</div><div class="t m7c x5c h80 y7d ff41 fs7c fc0 sc0 ls5a ws3d">mecânico</div><div class="t m7d x10 h81 y7e ff2 fs7d fc0 sc0 ls2">=</div><div class="t m7e x5d h82 y7f ff42 fs7e fc0 sc0 ls5b ws3e">musculação</div><div class="t m7f x5e h83 y80 ff43 fs7f fc0 sc0 ls2">)</div><div class="t m80 x5f h84 y81 ff2 fs80 fc0 sc0 ls2">,</div><div class="t m81 x60 h85 y82 ff2 fs81 fc0 sc0 ls5c">que</div><div class="t m82 x21 h86 y83 ff44 fs82 fc0 sc0 ls5d ws3f">pode</div><div class="t m83 x35 h87 y84 ff2 fs83 fc0 sc0 ls5e">ser</div><div class="t m84 x1b h88 y85 ff1 fs84 fc0 sc0 lse ws40">adaptativ<span class="blank _1"></span>o</div><div class="t m85 x61 h89 y86 ff2 fs85 fc0 sc0 ls5f">ou</div><div class="t m86 x62 h8a y87 ff2 fs86 fc0 sc0 ls60 ws41">não</div><div class="t m87 x63 h8b y88 ff2 fs87 fc0 sc0 ls2">,</div><div class="t m88 x64 h8c y89 ff2 fs88 fc0 sc0 ls61">ou</div><div class="t m89 x1d h8d y8a ff45 fs89 fc0 sc0 ls62 ws42">por</div><div class="t m8a x65 h8e y8b ff46 fs8a fc0 sc0 ls63 ws43">estímulo</div><div class="t m8b x27 h8f y8c ff47 fs8b fc0 sc0 ls64 ws44">lesivo</div><div class="t m8c x66 h90 y8d ff2 fs8c fc0 sc0 ls2">(</div><div class="t m8d x3c h91 y8e ff2 fs8d fc0 sc0 ls65">Ex</div><div class="t m8e x53 h92 y8f ff2 fs8e fc0 sc0 ls2">.</div><div class="t m8f x67 h93 y90 ff2 fs8f fc0 sc0 ls2">:</div><div class="t m90 x45 h94 y91 ff48 fs90 fc0 sc0 ls66 ws45">fa<span class="blank"> </span>l<span class="blank"> </span>ta</div><div class="t m91 x68 h95 y92 ff2 fs91 fc0 sc0 ls67">de</div><div class="t m92 x11 h96 y93 ff2 fs92 fc0 sc0 ls68">02</div><div class="t m93 x34 h97 y94 ff2 fs93 fc0 sc0 ls2">,</div><div class="t m94 x3f h98 y95 ff2 fs94 fc0 sc0 ls69">de</div><div class="t m95 x8 h99 y96 ff49 fs95 fc0 sc0 ls6a ws46">nutrientes</div><div class="t m96 x56 h9a y97 ff4a fs96 fc0 sc0 ls2">)</div><div class="t m97 x37 h9b y98 ff2 fs97 fc0 sc0 ls2">,</div><div class="t m98 x69 h9c y99 ff4b fs98 fc0 sc0 ls6b ws47">lev<span class="blank _0"></span>ando</div><div class="t m99 x1b h9d y9a ff2 fs99 fc0 sc0 ls2">a</div><div class="t m9a xc h9e y9b ff4c fs9a fc0 sc0 ls6c">lesão</div><div class="t m9b x6a h9f y9c ff2 fs9b fc0 sc0 ls2">.</div><div class="t m9c x6b ha0 y9d ff2 fs9c fc0 sc0 ls2">A</div><div class="t m9d x6c ha1 y9e ff4d fs9d fc0 sc0 ls6d ws48">lesão</div><div class="t m9e x6d ha2 y9f ff4e fs9e fc0 sc0 ls6e ws49">irre<span class="blank _0"></span>v<span class="blank _0"></span>ersív<span class="blank _0"></span>el</div><div class="t m9f x6e ha3 ya0 ff4f fs9f fc0 sc0 ls6f ws4a">lev<span class="blank _0"></span>a</div><div class="t ma0 x6f ha4 ya1 ff2 fsa0 fc0 sc0 ls2">à</div><div class="t ma1 x70 ha5 ya2 ff2 fsa1 fc0 sc0 ls70 ws4b">necrose</div><div class="t ma2 x71 ha6 ya3 ff2 fsa2 fc0 sc0 ls71">ou</div><div class="t ma3 x72 ha7 ya4 ff2 fsa3 fc0 sc0 ls2">a</div><div class="t ma4 x3f ha8 ya5 ff50 fsa4 fc0 sc0 ls72 ws4c">apoptose</div><div class="t ma5 x73 ha9 ya6 ff51 fsa5 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t ma6 x74 haa ya7 ff2 fsa6 fc0 sc0 ls73 ws4d">morte</div><div class="t ma7 x75 hab ya8 ff52 fsa7 fc0 sc0 ls74 ws4e">celular</div><div class="t ma8 x1b hac ya9 ffc fsa8 fc0 sc0 ls2">\u21b3</div><div class="t ma9 x76 had yaa ff53 fsa9 fc0 sc0 ls75 ws4f">adaptação</div><div class="t maa x1d hae yab ff54 fsaa fc0 sc0 ls76 ws50">pode</div><div class="t mab xe haf yac ff2 fsab fc0 sc0 ls77">ser</div><div class="t mac x77 hb0 yad ff2 fsac fc0 sc0 ls78">do</div><div class="t mad x5c hb1 yae ff55 fsad fc0 sc0 ls79">tipo</div><div class="t mae x78 hb2 yaf ff2 fsae fc0 sc0 ls2">:</div><div class="t maf xb hb3 yb0 ff2 fsaf fc0 sc0 ls2">-</div><div class="t mb0 x79 hb4 yb1 ff56 fsb0 fc0 sc0 lsf ws51">hiperplasia</div><div class="t mb1 xd hb5 yb2 ff57 fsb1 fc0 sc0 ls2">\u2192</div><div class="t mb2 x7a hb6 yb3 ff58 fsb2 fc0 sc0 ls7a ws52">aumento</div><div class="t mb3 x7b hb7 yb4 ff2 fsb3 fc0 sc0 ls7b">do</div><div class="t mb4 x0 hb8 yb5 ff59 fsb4 fc0 sc0 ls7c ws53">número</div><div class="t mb5 x7c hb9 yb6 ff2 fsb5 fc0 sc0 ls7d">de</div><div class="t mb6 x7d hba yb7 ff5a fsb6 fc0 sc0 ls7e ws54">células</div><div class="t mb7 x2d hbb yb8 ff2 fsb7 fc0 sc0 ls2">-</div><div class="t mb8 x79 hbc yb9 ff5b fsb8 fc0 sc0 ls7f ws55">hiper<span class="blank"> </span>tr<span class="blank _0"></span>ofia</div><div class="t mb9 x58 hbd yba ff57 fsb9 fc0 sc0 ls2">\u2192</div><div class="t mba x13 hbe ybb ff2 fsba fc0 sc0 ls80 ws56">aumento</div><div class="t mbb x7e hbf ybc ff2 fsbb fc0 sc0 ls81">do</div><div class="t mbc x2d hc0 ybd ff5c fsbc fc0 sc0 ls82 ws57">taman<span class="blank _2"> </span>ho</div><div class="t mbd x7f hc1 ybe ff5d fsbd fc0 sc0 ls83">das</div><div class="t mbe xd hc2 ybf ff5e fsbe fc0 sc0 ls84">células</div><div class="t mbf x2d hc3 yc0 ff2 fsbf fc0 sc0 ls2">-</div><div class="t mc0 x49 hc4 yc1 ff5f fsc0 fc0 sc0 ls85 ws58">atr<span class="blank _0"></span>ofia</div><div class="t mc1 x1c hc5 yc2 ff57 fsc1 fc0 sc0 ls2">\u2192</div><div class="t mc2 x80 hc6 yc3 ff60 fsc2 fc0 sc0 ls86">diminuição</div><div class="t mc3 x7e hc7 yc4 ff61 fsc3 fc0 sc0 ls87">do</div><div class="t mc4 x31 hc8 yc5 ff62 fsc4 fc0 sc0 ls88 ws59">tamanho</div><div class="t mc5 x45 hc9 yc6 ff2 fsc5 fc0 sc0 ls89 ws5a">por</div><div class="t mc6 x2d hca yc7 ff63 fsc6 fc0 sc0 ls8a ws5b">fa<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>a</div><div class="t mc7 x7c hcb yc8 ff2 fsc7 fc0 sc0 ls8b">de</div><div class="t mc8 x63 hcc yc9 ff64 fsc8 fc0 sc0 ls8c ws5c">estímulo</div><div class="t mc9 x65 hcd yca ff65 fsc9 fc0 sc0 ls2">(</div><div class="t mca x1 hce ycb ff2 fsca fc0 sc0 ls8d">pelo</div><div class="t mcb x77 hcf ycc ff66 fscb fc0 sc0 ls8e">desuso</div><div class="t mcc x44 hd0 ycd ff2 fscc fc0 sc0 ls8f">ou</div><div class="t mcd x4d hd1 yce ff67 fscd fc0 sc0 ls90">pela</div><div class="t mce x3c hd2 ycf ff68 fsce fc0 sc0 ls91 ws5d">fa<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>a</div><div class="t mcf x81 hd3 yd0 ff2 fscf fc0 sc0 ls92">de</div><div class="t md0 x82 hd4 yd1 ff69 fsd0 fc0 sc0 ls93 ws5e">nutrientes</div><div class="t md1 x5f hd5 yd2 ff6a fsd1 fc0 sc0 ls2">)</div><div class="t md2 x2d hd6 yd3 ff2 fsd2 fc0 sc0 ls2">-</div><div class="t md3 x49 hd7 yd4 ff6b fsd3 fc0 sc0 ls94 ws5f">metaplasia</div><div class="t md4 x80 hd8 yd5 ff57 fsd4 fc0 sc0 ls2">\u2192</div><div class="t md5 x5a hd9 yd6 ff2 fsd5 fc0 sc0 ls95">um</div><div class="t md6 x83 hda yd7 ff6c fsd6 fc0 sc0 ls96">tipo</div><div class="t md7 x7e hdb yd8 ff6d fsd7 fc0 sc0 ls97">celular</div><div class="t md8 x2 hdc yd9 ff2 fsd8 fc0 sc0 ls2">é</div><div class="t md9 x84 hdd yda ff6e fsd9 fc0 sc0 ls98 ws60">substituído</div><div class="t mda x2d hde ydb ff2 fsda fc0 sc0 ls99 ws61">por</div><div class="t mdb x85 hdf ydc ff6f fsdb fc0 sc0 ls9a ws62">outro</div><div class="t mdc x86 he0 ydd ff70 fsdc fc0 sc0 ls2">(</div><div class="t mdd x1c he1 yde ff2 fsdd fc0 sc0 ls9b">Ex</div><div class="t mde x87 he2 ydf ff2 fsde fc0 sc0 ls2">:</div><div class="t mdf x6c he3 ye0 ff2 fsdf fc0 sc0 ls10 ws63">como</div><div class="t me0 xe he4 ye1 ff71 fse0 fc0 sc0 ls9c">pela</div><div class="t me1 x88 he5 ye2 ff72 fse1 fc0 sc0 ls9d ws64">fumaça</div><div class="t me2 x89 he6 ye3 ff73 fse2 fc0 sc0 ls9e">do</div><div class="t me3 x84 he7 ye4 ff74 fse3 fc0 sc0 ls9f ws65">cigarro</div><div class="t me4 x8a he8 ye5 ff2 fse4 fc0 sc0 ls2">I</div><div class="t me5 x2d he9 ye6 ffc fse5 fc0 sc0 ls2">\u21b3</div><div class="t me6 x79 hea ye7 ff75 fse6 fc0 sc0 lsa0 ws66">reve<span class="blank"> </span>rs<span class="blank"> </span>i<span class="blank"> </span>b<span class="blank"> </span>i<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>e</div><div class="t me7 x8b heb ye8 ff2 fse7 fc0 sc0 ls2">:</div><div class="t me8 xb hec ye9 ff2 fse8 fc0 sc0 ls2">\u2022</div><div class="t me9 xc hed yea ff76 fse9 fc0 sc0 lsa1 ws67">Mor<span class="blank"> </span>te</div><div class="t mea x86 hee yeb ff77 fsea fc0 sc0 lsa2 ws68">celular</div><div class="t meb x8c hef yec ff2 fseb fc0 sc0 ls2">:</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf3" class="pf w0 hc" data-page-no="3"><div class="pc pc3 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg3.png"><div class="t mec x2d hf0 yed ffc fsec fc0 sc0 ls2">\u21b3</div><div class="t med x79 hf1 yee ff78 fsed fc0 sc0 lsae ws69">Necrose</div><div class="t mee x6b hf2 yef ff2 fsee fc0 sc0 ls2">:</div><div class="t mef xb hf3 yf0 ff2 fsef fc0 sc0 ls2">-</div><div class="t mf0 x85 hf4 yf1 ff2 fsf0 fc0 sc0 ls2">é</div><div class="t mf1 x2e hf5 yf2 ff79 fsf1 fc0 sc0 lsaf ws6a">patológica</div><div class="t mf2 x50 hf6 yf3 ff2 fsf2 fc0 sc0 ls2">,</div><div class="t mf3 x3a hf7 yf4 ff2 fsf3 fc0 sc0 lsb0 ws6b">causada</div><div class="t mf4 x27 hf8 yf5 ff7a fsf4 fc0 sc0 lsb1">pela</div><div class="t mf5 x8d hf9 yf6 ff7b fsf5 fc0 sc0 lsa3 ws6c">diminuição</div><div class="t mf6 x8e hfa yf7 ff7c fsf6 fc0 sc0 lsb2">da</div><div class="t mf7 x54 hfb yf8 ff7d fsf7 fc0 sc0 lsb3 ws6d">concentração</div><div class="t mf8 x8f hfc yf9 ff2 fsf8 fc0 sc0 lsb4">de</div><div class="t mf9 x90 hfd yfa ff7e fsf9 fc0 sc0 lsb5">Oz</div><div class="t mfa x1a hfe yfb ff2 fsfa fc0 sc0 ls2">.</div><div class="t mfb x1b hff yfc ff7f fsfb fc0 sc0 lsb6 ws6e">portanto</div><div class="t mfc x1c h100 yfd ff2 fsfc fc0 sc0 lsa4 ws6f">causa</div><div class="t mfd x13 h101 yfe ff80 fsfd fc0 sc0 lsb7">inflamação</div><div class="t mfe x91 h102 yff ff81 fsfe fc0 sc0 lsb8 ws70">devido</div><div class="t mff x53 h103 y100 ff2 fsff fc0 sc0 ls2">a</div><div class="t m100 x45 h104 y101 ff82 fs100 fc0 sc0 lsa5 ws71">liberação</div><div class="t m101 x54 h105 y102 ff83 fs101 fc0 sc0 lsb9">de</div><div class="t m102 x20 h106 y103 ff84 fs102 fc0 sc0 lsba ws72">substâncias</div><div class="t m103 x2d h107 y104 ff2 fs103 fc0 sc0 ls2">-</div><div class="t m104 xc h108 y105 ff2 fs104 fc0 sc0 ls2">é</div><div class="t m105 x61 h109 y106 ff85 fs105 fc0 sc0 lsbb ws73">acidental</div><div class="t m106 x5a h10a y107 ff2 fs106 fc0 sc0 ls2">/</div><div class="t m107 x92 h10b y108 ff86 fs107 fc0 sc0 lsbc ws74">traumática</div><div class="t m108 x0 h10c y109 ff2 fs108 fc0 sc0 ls2">-</div><div class="t m109 xc h10d y10a ff2 fs109 fc0 sc0 lsbd ws75">ocorre</div><div class="t m10a x1c h10e y10b ff87 fs10a fc0 sc0 lsbe ws76">desnaturouáo</div><div class="t m10b x5c h10f y10c ff88 fs10b fc0 sc0 lsbf ws77">pr<span class="blank _0"></span>oteica</div><div class="t m10c x2d h110 y10d ff2 fs10c fc0 sc0 ls2">-</div><div class="t m10d x93 h111 y10e ff2 fs10d fc0 sc0 lsa6 ws78">ocorre</div><div class="t m10e x94 h112 y10f ff89 fs10e fc0 sc0 lsc0 ws79">autólise</div><div class="t m10f x5b h113 y110 ff51 fs10f fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m110 x14 h114 y111 ff8a fs110 fc0 sc0 lsc1 ws7a">codegeodaçáo</div><div class="t m111 x1f h115 y112 ff8b fs111 fc0 sc0 lsc2 ws7b">enzimática</div><div class="t m112 x68 h116 y113 ff2 fs112 fc0 sc0 lsc3">dos</div><div class="t m113 x95 h117 y114 ff8c fs113 fc0 sc0 lsc4 ws7c">componentes</div><div class="t m114 x96 h118 y115 ff8d fs114 fc0 sc0 lsc5 ws7d">celulares</div><div class="t m115 x2d h119 y116 ff2 fs115 fc0 sc0 lsc6 ws7e">por</div><div class="t m116 x57 h11a y117 ff8e fs116 fc0 sc0 lsc7 ws7f">enzimas</div><div class="t m117 x8c h11b y118 ff8f fs117 fc0 sc0 lsc8">da</div><div class="t m118 x65 h11c y119 ff90 fs118 fc0 sc0 lsc9 ws80">pr<span class="blank _0"></span>ópria</div><div class="t m119 x97 h11d y11a ff91 fs119 fc0 sc0 lsca ws81">célula</div><div class="t m11a x8d h11e y11b ff2 fs11a fc0 sc0 lscb">que</div><div class="t m11b x53 h11f y11c ff2 fs11b fc0 sc0 lscc ws82">são</div><div class="t m11c x98 h120 y11d ff92 fs11c fc0 sc0 lscd ws83">liberadas</div><div class="t m11d x99 h121 y11e ff2 fs11d fc0 sc0 lsce">de</div><div class="t m11e x9a h122 y11f ff93 fs11e fc0 sc0 lscf ws84">lisossomos</div><div class="t m11f x9b h123 y120 ff2 fs11f fc0 sc0 lsd0 ws85">após</div><div class="t m120 x0 h124 y121 ff2 fs120 fc0 sc0 ls2">a</div><div class="t m121 x9c h125 y122 ff2 fs121 fc0 sc0 lsd1 ws86">mor<span class="blank"> </span>te</div><div class="t m122 x39 h126 y123 ff94 fs122 fc0 sc0 lsd2 ws87">celular</div><div class="t m123 x1b h127 y124 ff2 fs123 fc0 sc0 ls2">-</div><div class="t m124 x93 h128 y125 ff2 fs124 fc0 sc0 lsd3 ws88">ocorre</div><div class="t m125 x6a h129 y126 ff95 fs125 fc0 sc0 lsd4 ws89">heter<span class="blank _0"></span>ólise</div><div class="t m126 x65 h12a y127 ff51 fs126 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m127 x9d h12b y128 ff96 fs127 fc0 sc0 lsd5 ws8a">colapso</div><div class="t m128 x9e h12c y129 ff2 fs128 fc0 sc0 ls2">e</div><div class="t m129 x4d h12d y12a ff97 fs129 fc0 sc0 lsd6 ws8b">ruptura</div><div class="t m12a x9f h12e y12b ff2 fs12a fc0 sc0 lsd7">da</div><div class="t m12b x3e h12f y12c ff98 fs12b fc0 sc0 lsd8 ws8c">membrana</div><div class="t m12c xa0 h130 y12d ff99 fs12c fc0 sc0 lsa7 ws8d">plasmática</div><div class="t m12d xa1 h131 y12e ff2 fs12d fc0 sc0 ls2">,</div><div class="t m12e x2d h132 y12f ff9a fs12e fc0 sc0 lsd9">por</div><div class="t m12f x76 h133 y130 ff2 fs12f fc0 sc0 lsda ws8e">isso</div><div class="t m130 x24 h134 y131 ff2 fs130 fc0 sc0 lsdb ws8f">ocorre</div><div class="t m131 x25 h135 y132 ff2 fs131 fc0 sc0 lsdc">de</div><div class="t m132 x6d h136 y133 ff2 fs132 fc0 sc0 lsdd">maneira</div><div class="t m133 xa2 h137 y134 ff2 fs133 fc0 sc0 lsde">mais</div><div class="t m134 xa3 h138 y135 ff9b fs134 fc0 sc0 lsdf ws90">rápid<span class="blank _2"> </span>a</div><div class="t m135 xa4 h139 y136 ff2 fs135 fc0 sc0 ls2">,</div><div class="t m136 xa5 h13a y137 ff2 fs136 fc0 sc0 lse0">com</div><div class="t m137 x34 h13b y138 ff2 fs137 fc0 sc0 lse1 ws91">processo</div><div class="t m138 x73 h13c y139 ff9c fs138 fc0 sc0 lsa8 ws92">inflamatório</div><div class="t m139 x1b h13d y13a ff9d fs139 fc0 sc0 lse2 ws93">desencadeado</div><div class="t m13a x59 h13e y13b ff9e fs13a fc0 sc0 lse3">pelo</div><div class="t m13b x7a h86 y13c ff9f fs82 fc0 sc0 lse4 ws94">rec<span class="blank"> </span>r<span class="blank"> </span>u<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>e<span class="blank"> </span>n<span class="blank"> </span>to</div><div class="t m13c x8d h13f y13d ffa0 fs13b fc0 sc0 lse5 ws95">celular</div><div class="t m13d x8a h140 y13e ffa1 fs13c fc0 sc0 lse6 ws96">leetrav<span class="blank _0"></span>arament<span class="blank _0"></span>o</div><div class="t m13e xa h141 y13f ff2 fs13d fc0 sc0 lse7">de</div><div class="t m13f x56 h142 y140 ffa2 fs13e fc0 sc0 lse8 ws97">lisossomos</div><div class="t m140 x0 h143 y141 ff2 fs13f fc0 sc0 lse9">no</div><div class="t m141 x49 h144 y142 ff2 fs140 fc0 sc0 ls2">-</div><div class="t m142 x85 h145 y143 ffa3 fs141 fc0 sc0 lsea ws98">ãloplasma</div><div class="t m143 x4a h146 y144 ff2 fs142 fc0 sc0 lseb ws99">lev<span class="blank _0"></span>a</div><div class="t m144 x6d h147 y145 ff2 fs143 fc0 sc0 ls2">a</div><div class="t m145 xa6 h148 y146 ffa4 fs144 fc0 sc0 lsec ws9a">digestão</div><div class="t m146 xa7 h149 y147 ff2 fs145 fc0 sc0 lsed">da</div><div class="t m147 xa8 h14a y148 ffa5 fs146 fc0 sc0 lsee ws9b">célula</div><div class="t m148 xa9 h14b y149 ffa6 fs147 fc0 sc0 ls2">)</div><div class="t m149 x1b h14c y14a ff2 fs148 fc0 sc0 ls2">-</div><div class="t m14a xaa h14d y14b ff2 fs149 fc0 sc0 ls2">é</div><div class="t m14b x57 h14e y14c ff2 fs14a fc0 sc0 ls2">a</div><div class="t m14c xab h14f y14d ff2 fs14b fc0 sc0 lsef">maior</div><div class="t m14d xac h150 y14e ff2 fs14c fc0 sc0 lsf0">via</div><div class="t m14e xad h151 y14f ffa7 fs14d fc0 sc0 lsf1">de</div><div class="t m14f x14 h152 y150 ff2 fs14e fc0 sc0 lsf2 ws9c">morte</div><div class="t m150 x7b h153 y151 ff2 fs14f fc0 sc0 lsf3 ws9d">celular</div><div class="t m151 x66 h154 y152 ff2 fs150 fc0 sc0 lsf4">na</div><div class="t m152 xae h155 y153 ff2 fs151 fc0 sc0 lsf5">maioria</div><div class="t m153 xaf h156 y154 ff2 fs152 fc0 sc0 lsf6 ws9e">das</div><div class="t m154 x61 h157 y155 ffa8 fs153 fc0 sc0 lsf7 ws9f">lesões</div><div class="t m155 xb0 h158 y156 ffa9 fs154 fc0 sc0 lsf8 wsa0">encontradas</div><div class="t m156 xf h159 y157 ff2 fs155 fc0 sc0 ls2">,</div><div class="t m157 x26 h15a y158 ff2 fs156 fc0 sc0 lsa9 wsa1">como</div><div class="t m158 xb1 h15b y159 ff2 fs157 fc0 sc0 lsf9">as</div><div class="t m159 x1f h15c y15a ff2 fs158 fc0 sc0 lsfa">que</div><div class="t m15a x6f h15d y15b ffaa fs159 fc0 sc0 lsfb wsa2">res<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>m</div><div class="t m15b x2d h15e y15c ff2 fs15a fc0 sc0 lsfc">de</div><div class="t m15c x85 h15f y15d ffab fs15b fc0 sc0 lsfd">isquemia</div><div class="t m15d x80 h160 y15e ff2 fs15c fc0 sc0 ls2">,</div><div class="t m15e xb2 h161 y15f ffac fs15d fc0 sc0 lsfe wsa3">exp<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank"> </span>i<span class="blank"> </span>ç<span class="blank"> </span>ã<span class="blank"> </span>o</div><div class="t m15f xf h162 y160 ff2 fs15e fc0 sc0 ls2">e</div><div class="t m160 x7e h163 y161 ffad fs15f fc0 sc0 lsff wsa4">botinas</div><div class="t m161 xb3 h164 y162 ff2 fs160 fc0 sc0 ls2">,</div><div class="t m162 x16 h165 y163 ffae fs161 fc0 sc0 ls100 wsa5">inf<span class="blank _0"></span>ecções</div><div class="t m163 x82 h166 y164 ff2 fs162 fc0 sc0 ls2">e</div><div class="t m164 x1b h167 y165 ffaf fs163 fc0 sc0 ls101">traumas</div><div class="t m165 xb h168 y166 ff2 fs164 fc0 sc0 ls2">-</div><div class="t m166 x85 h169 y167 ffb0 fs165 fc0 sc0 ls102 wsa6">mecanismo</div><div class="t m167 x50 h16a y168 ff51 fs166 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m168 xe h16b y169 ffb1 fs167 fc0 sc0 ls103 wsa7">primeir<span class="blank _0"></span>o</div><div class="t m169 x4c h16c y16a ff2 fs168 fc0 sc0 ls104 wsa8">ocorre</div><div class="t m16a x1b h16d y16b ff1 fs169 fc0 sc0 lsaa wsa9">int<span class="blank _0"></span>err<span class="blank _1"></span>ompiment<span class="blank _0"></span>o</div><div class="t m16b x7c h16e y16c ffb2 fs16a fc0 sc0 ls105">das</div><div class="t m16c xb4 h16f y16d ffb3 fs16b fc0 sc0 ls106 wsaa">funções</div><div class="t m16d x1 h170 y16e ffb4 fs16c fc0 sc0 ls107 wsab">vitais</div><div class="t m16e x52 h171 y16f ff2 fs16d fc0 sc0 ls2">(</div><div class="t m16f xb5 h172 y170 ff2 fs16e fc0 sc0 ls2">+</div><div class="t m170 xb1 h173 y171 ffb5 fs16f fc0 sc0 ls108 wsac">produção</div><div class="t m171 xb6 h174 y172 ff2 fs170 fc0 sc0 ls109">de</div><div class="t m172 xb h175 y173 ffb6 fs171 fc0 sc0 lsab wsad">ener<span class="blank _0"></span>gia</div><div class="t m173 x24 h176 y174 ff2 fs172 fc0 sc0 ls2">e</div><div class="t m174 xb4 h177 y175 ff2 fs173 fc0 sc0 ls2">&</div><div class="t m175 x59 h178 y176 ff2 fs174 fc0 sc0 ls10a wsae">sínteses</div><div class="t m176 x4b h179 y177 ffb7 fs175 fc0 sc0 ls10b wsaf">celulares</div><div class="t m177 x4d h17a y178 ffb8 fs176 fc0 sc0 ls2">)</div><div class="t m178 x8d h17b y179 ff2 fs177 fc0 sc0 ls2">,</div><div class="t m179 x84 h17c y17a ffb9 fs178 fc0 sc0 ls10c wsb0">então</div><div class="t m17a x2d h17d y17b ff2 fs179 fc0 sc0 ls10d">os</div><div class="t m17b x85 h17e y17c ffba fs17a fc0 sc0 ls10e wsb1">hidr<span class="blank _0"></span>of<span class="blank _1"></span>ones</div><div class="t m17c xb2 h17f y17d ffbb fs17b fc0 sc0 ls2">(</div><div class="t m17d xb7 h180 y17e ffbc fs17c fc0 sc0 ls10f wsb2">prot<span class="blank _0"></span>ease</div><div class="t m17e x15 h181 y17f ff2 fs17d fc0 sc0 ls2">,</div><div class="t m17f x7e h182 y180 ffbd fs17e fc0 sc0 ls110 wsb3">dipases</div><div class="t m180 x1f h183 y181 ff2 fs17f fc0 sc0 ls2">,</div><div class="t m181 xb8 h184 y182 ffbe fs180 fc0 sc0 ls111">gleioidases</div><div class="t m182 xb9 h185 y183 ff2 fs181 fc0 sc0 ls2">,</div><div class="t m183 x2d h186 y184 ff2 fs182 fc0 sc0 ls112">RNA</div><div class="t m184 xba h187 y185 ff2 fs183 fc0 sc0 ls113 wsb4">res</div><div class="t m185 xbb h188 y186 ff2 fs184 fc0 sc0 ls2">,</div><div class="t m186 x94 h189 y187 ff2 fs185 fc0 sc0 ls114 wsb5">DNA</div><div class="t m187 xb4 h18a y188 ff2 fs186 fc0 sc0 ls115">ser</div><div class="t m188 x4a h18b y189 ffbf fs187 fc0 sc0 ls2">)</div><div class="t m189 x25 h18c y18a ff2 fs188 fc0 sc0 ls116 wsb6">são</div><div class="t m18a x9d h18d y18b ffc0 fs189 fc0 sc0 ls117 wsb7">liberadas</div><div class="t m18b x3b h18e y18c ff2 fs18a fc0 sc0 ls118">do</div><div class="t m18c x3 h18f y18d ffc1 fs18b fc0 sc0 ls119 wsb8">lisossomo</div><div class="t m18d x2d h190 y18e ff2 fs18c fc0 sc0 ls11a wsb9">para</div><div class="t m18e xbc h191 y18f ff2 fs18d fc0 sc0 ls2">o</div><div class="t m18f x23 h192 y190 ffc2 fs18e fc0 sc0 ls11b wsba">àtool</div><div class="t m190 x1d h193 y191 ff2 fs18f fc0 sc0 ls2">,</div><div class="t m191 xb7 h194 y192 ff2 fs190 fc0 sc0 ls11c">sendo</div><div class="t m192 xa6 h195 y193 ff2 fs191 fc0 sc0 ls11d wsbb">capazes</div><div class="t m193 xb1 h196 y194 ff2 fs192 fc0 sc0 ls11e">de</div><div class="t m194 x8d h197 y195 ffc3 fs193 fc0 sc0 ls11f wsbc">digerir</div><div class="t m195 x9f h198 y196 ffc4 fs194 fc0 sc0 ls120 wsbd">substratos</div><div class="t m196 x3f h199 y197 ffc5 fs195 fc0 sc0 ls121 wsbe">celulares</div><div class="t m197 x73 h19a y198 ff2 fs196 fc0 sc0 ls2">.</div><div class="t m198 x35 h19b y199 ff2 fs197 fc0 sc0 ls122 wsbf">Por</div><div class="t m199 x2b h19c y19a ffc6 fs198 fc0 sc0 lsac wsc0">fim</div><div class="t m19a x8f h19d y19b ff2 fs199 fc0 sc0 ls2">,</div><div class="t m19b xb h19e y19c ffc7 fs19a fc0 sc0 ls123 wsc1">res<span class="blank"> </span>p<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>s</div><div class="t m19c xbd h19f y19d ffc8 fs19b fc0 sc0 ls124 wsc2">ativadas</div><div class="t m19d x1 h1a0 y19e ffc9 fs19c fc0 sc0 ls125 wsc3">pela</div><div class="t m19e xf h1a1 y19f ffca fs19d fc0 sc0 ls126">alta</div><div class="t m19f x44 h1a2 y1a0 ffcb fs19e fc0 sc0 ls127 wsc4">concentração</div><div class="t m1a0 x17 h1a3 y1a1 ff2 fs19f fc0 sc0 ls128">de</div><div class="t m1a1 xa4 h1a4 y1a2 ff2 fs1a0 fc0 sc0 ls129">ca</div><div class="t m1a2 x18 h1a5 y1a3 ff2 fs1a1 fc0 sc0 ls2">"</div><div class="t m1a3 x5f h1a6 y1a4 ff2 fs1a2 fc0 sc0 ls12a">no</div><div class="t m1a4 xbe h1a7 y1a5 ffcc fs1a3 fc0 sc0 ls12b wsc5">citoplasma</div><div class="t m1a5 x56 h1a8 y1a6 ff2 fs1a4 fc0 sc0 ls2">,</div><div class="t m1a6 xbf h1a9 y1a7 ffcd fs1a5 fc0 sc0 ls12c">iniciam</div><div class="t m1a7 x2d h1aa y1a8 ff2 fs1a6 fc0 sc0 ls2">o</div><div class="t m1a8 xc h1ab y1a9 ffce fs1a7 fc0 sc0 ls12d wsc6">processo</div><div class="t m1a9 x7f h1ac y1aa ff2 fs1a8 fc0 sc0 ls12e">de</div><div class="t m1aa x8c h1ad y1ab ffcf fs1a9 fc0 sc0 ls12f wsc7">autólise</div><div class="t m1ab xc0 h1ae y1ac ff2 fs1aa fc0 sc0 ls2">.</div><div class="t m1ac xb h1af y1ad ff2 fs1ab fc0 sc0 ls2">-</div><div class="t m1ad x85 h1b0 y1ae ffd0 fs1ac fc0 sc0 ls130 wsc8">alterações</div><div class="t m1ae x6c h1b1 y1af ffd1 fs1ad fc0 sc0 ls131 wsc9">nucleares</div><div class="t m1af x88 h1b2 y1b0 ff2 fs1ae fc0 sc0 ls2">:</div><div class="t m1b0 xaf h1b3 y1b1 ff2 fs1af fc0 sc0 ls2">a</div><div class="t m1b1 x79 h1b4 y1b2 ff2 fs1b0 fc0 sc0 ls2">.</div><div class="t m1b2 xba h1b5 y1b3 ffd2 fs1b1 fc0 sc0 ls132 wsca">caridise</div><div class="t m1b3 xac h1b6 y1b4 ff51 fs1b2 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1b4 x13 h1b7 y1b5 ffd3 fs1b3 fc0 sc0 ls133 wscb">núcleo</div><div class="t m1b5 xf h1b8 y1b6 ffd4 fs1b4 fc0 sc0 ls134 wscc">desbotado</div><div class="t m1b6 x3b h1b9 y1b7 ff2 fs1b5 fc0 sc0 ls2">e</div><div class="t m1b7 x84 h1ba y1b8 ffd5 fs1b6 fc0 sc0 ls135 wscd">dissolvido</div><div class="t m1b8 xb h1bb y1b9 ffd6 fs1b7 fc0 sc0 ls2">(</div><div class="t m1b9 x93 h1bc y1ba ffd7 fs1b8 fc0 sc0 ls136 wsce">digestão</div><div class="t m1ba xb4 h1bd y1bb ff2 fs1b9 fc0 sc0 ls137">do</div><div class="t m1bb xb7 h1be y1bc ffd8 fs1ba fc0 sc0 ls138">DNA</div><div class="t m1bc x6d h1bf y1bd ffd9 fs1bb fc0 sc0 ls2">)</div><div class="t m1bd x2d h1c0 y1be ffda fs1bc fc0 sc0 ls139">b.</div><div class="t m1be x76 h1c1 y1bf ffdb fs1bd fc0 sc0 ls13a wscf">pior<span class="blank _0"></span>ou</div><div class="t m1bf x7f h1c2 y1c0 ff51 fs1be fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1c0 x41 h1c3 y1c1 ffdc fs1bf fc0 sc0 lsad wsd0">r<span class="blank _0"></span>etração<span class="blank _0"></span></div><div class="t m1c1 x4b h1c4 y1c2 ffdd fs1c0 fc0 sc0 ls13b wsd1">nuclear</div><div class="t m1c2 x1b h1c5 y1c3 ff2 fs1c1 fc0 sc0 ls2">e</div><div class="t m1c3 xc1 h1c6 y1c4 ff2 fs1c2 fc0 sc0 ls2">.</div><div class="t m1c4 x4f h1c7 y1c5 ffde fs1c3 fc0 sc0 ls13c wsd2">cariovux<span class="blank _0"></span>e</div><div class="t m1c5 xc2 h1c8 y1c6 ff51 fs1c4 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1c6 xd h1c9 y1c7 ffdf fs1c5 fc0 sc0 ls13d wsd3">fragmentação</div><div class="t m1c7 x31 h1ca y1c8 ff2 fs1c6 fc0 sc0 ls13e wsd4">nuclear</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf4" class="pf w0 hc" data-page-no="4"><div class="pc pc4 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg4.png"><div class="t m1c8 xb h1cb y1c9 ff2 fs1c7 fc0 sc0 ls2">-</div><div class="t m1c9 x93 h1cc y1ca ffe0 fs1c8 fc0 sc0 ls150 wsd5">alter<span class="blank _0"></span>ações</div><div class="t m1ca x41 h1cd y1cb ffe1 fs1c9 fc0 sc0 ls13f wsd6">àtoplasmíatvias</div><div class="t m1cb xb1 h1ce y1cc ff2 fs1ca fc0 sc0 ls2">:</div><div class="t m1cc x2d h1cf y1cd ff2 fs1cb fc0 sc0 ls151">a.</div><div class="t m1cd x85 h1d0 y1ce ff1 fs1cc fc0 sc0 ls152 wsd7">tom<span class="blank"> </span>a</div><div class="t m1ce x59 h1d1 y1cf ff51 fs1cd fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1cf x5a h1d2 y1d0 ffe2 fs1ce fc0 sc0 ls153 wsd8">pr<span class="blank _0"></span>oteínas</div><div class="t m1d0 x5c h1d3 y1d1 ffe3 fs1cf fc0 sc0 ls140 wsd9">citoplasmático</div><div class="t m1d1 x98 h1d4 y1d2 ffe4 fs1d0 fc0 sc0 ls154 wsda">desnaturadas</div><div class="t m1d2 x9 h1d5 y1d3 ff2 fs1d1 fc0 sc0 ls155">que</div><div class="t m1d3 x2b h1d6 y1d4 ff2 fs1d2 fc0 sc0 ls156">se</div><div class="t m1d4 x22 h1d7 y1d5 ffe5 fs1d3 fc0 sc0 ls141 wsdb">ligam</div><div class="t m1d5 x1b h1d8 y1d6 ffe6 fs1d4 fc0 sc0 ls2">à</div><div class="t m1d6 x79 h1d9 y1d7 ffe7 fs1d5 fc0 sc0 ls157 wsdc">eosina</div><div class="t m1d7 x2d h1da y1d8 ff2 fs1d6 fc0 sc0 ls158">b.</div><div class="t m1d8 xc h1db y1d9 ffe8 fs1d7 fc0 sc0 ls142 wsdd">apar<span class="blank _0"></span>ência</div><div class="t m1d9 xb2 h1dc y1da ffe9 fs1d8 fc0 sc0 ls143 wsde">vítr<span class="blank _0"></span>ea</div><div class="t m1da xc0 h1dd y1db ff51 fs1d9 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1db x15 h1de y1dc ffea fs1da fc0 sc0 ls159 wsdf">per<span class="blank _0"></span>da</div><div class="t m11d xc3 h1df y1dd ffeb fs1db fc0 sc0 ls15a">de</div><div class="t m1dc xc4 h1e0 y1de ffec fs1dc fc0 sc0 ls15b wse0">partículas</div><div class="t m1dd xc5 h1e1 y1df ffed fs1dd fc0 sc0 ls15c">de</div><div class="t m1de x2a h1e2 y1e0 ffee fs1de fc0 sc0 ls15d wse1">glicogênio</div><div class="t m1df x2d h1e3 y1e1 ff2 fs1df fc0 sc0 ls15e">c.</div><div class="t m1e0 x79 h1e4 y1e2 ffef fs1e0 fc0 sc0 ls15f wse2">citoplasma</div><div class="t m1e1 x4a h1e5 y1e3 fff0 fs1e1 fc0 sc0 ls160 wse3">var<span class="blank"> </span>i<span class="blank"> </span>e<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>e</div><div class="t m1e2 x1e h1e6 y1e4 ff51 fs1e2 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1e3 xa2 h1e7 y1e5 fff1 fs1e3 fc0 sc0 ls161 wse4">digestão</div><div class="t m1e4 x70 h1e8 y1e6 fff2 fs1e4 fc0 sc0 lsb9">de</div><div class="t m1e5 xc6 h1e9 y1e7 fff3 fs1e5 fc0 sc0 ls144 wse5">or<span class="blank _0"></span>ganelas</div><div class="t m1e6 x1b h1ea y1e8 ff2 fs1e6 fc0 sc0 ls162">d.</div><div class="t m1e7 xc h1eb y1e9 fff4 fs1e7 fc0 sc0 ls163">descontinuidade</div><div class="t m1e8 xc7 h1ec y1ea fff5 fs1e8 fc0 sc0 ls164">da</div><div class="t m1e9 xf h1ed y1eb ff2 fs1e9 fc0 sc0 ls165">membrana</div><div class="t m1ea xae h1ee y1ec fff6 fs1ea fc0 sc0 ls145 wse6">plasmática</div><div class="t m1eb xc8 h1ef y1ed ff2 fs1eb fc0 sc0 ls2">e</div><div class="t m1ec x19 h1f0 y1ee fff7 fs1ec fc0 sc0 ls166">da</div><div class="t m1ed xc9 h1f1 y1ef fff8 fs1ed fc0 sc0 ls167 wse7">membrana</div><div class="t m1ee x2d h1f2 y1f0 ff2 fs1ee fc0 sc0 ls168 wse8">das</div><div class="t m1ef x2e h1f3 y1f1 fff9 fs1ef fc0 sc0 ls146 wse9">or<span class="blank _0"></span>ganelas</div><div class="t m1f0 x73 h1f4 y1f2 ff2 fs1f0 fc0 sc0 ls169">A)</div><div class="t m1f1 xb h1f5 y1f3 ff2 fs1f1 fc0 sc0 ls2">-</div><div class="t m1f2 x79 h1f6 y1f4 fffa fs1f2 fc0 sc0 ls16a">tipos</div><div class="t m1f3 xca h1f7 y1f5 fffb fs1f3 fc0 sc0 ls16b">de</div><div class="t m1f4 xb4 h1f8 y1f6 ff2 fs1f4 fc0 sc0 ls16c wsea">necrose</div><div class="t m1f5 x42 h1f9 y1f7 ff2 fs1f5 fc0 sc0 ls2">:</div><div class="t m1f6 x2d h1fa y1f8 ff2 fs1f6 fc0 sc0 ls16d">a.</div><div class="t m1f7 x4f h1fb y1f9 ff2 fs1f7 fc0 sc0 ls16e wseb">necrose</div><div class="t m1f8 x7f h1fc y1fa ff2 fs1f8 fc0 sc0 ls16f">de</div><div class="t m1f9 xb2 h1fd y1fb fffc fs1f9 fc0 sc0 ls170 wsec">coagulação</div><div class="t m1fa x15 h1fe y1fc ff51 fs1fa fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m1fb x27 h1ff y1fd ff2 fs1fb fc0 sc0 ls171 wsed">tecid<span class="blank _2"> </span>o</div><div class="t m1fc x8d h200 y1fe fffd fs1fc fc0 sc0 ls172 wsee">firme</div><div class="t m1fd xb6 h201 y1ff ff2 fs1fd fc0 sc0 ls2">e</div><div class="t m1fe x82 h202 y200 fffe fs1fe fc0 sc0 ls173 wsef">pálido</div><div class="t m1ff x5e h203 y201 ff2 fs1ff fc0 sc0 ls174">ou</div><div class="t m200 xc8 h204 y202 ffff fs200 fc0 sc0 ls175 wsf0">amarelado</div><div class="t m201 x2d h205 y203 ff2 fs201 fc0 sc0 ls176">b.</div><div class="t m202 x49 h206 y204 ff2 fs202 fc0 sc0 ls177 wsf1">necrose</div><div class="t m203 xbd h207 y205 ff100 fs203 fc0 sc0 ls2 wsf2">liopuef<span class="blank _0"></span>ativa</div><div class="t m204 xcb h208 y206 ff51 fs204 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m205 x15 h209 y207 ff101 fs205 fc0 sc0 ls178 wsf3">tecid<span class="blank _2"> </span>os</div><div class="t m206 x4d h20a y208 ff102 fs206 fc0 sc0 ls179 wsf4">celulares</div><div class="t m207 x81 h20b y209 ff103 fs207 fc0 sc0 ls17a wsf5">tiram</div><div class="t m208 x68 h20c y20a ff2 fs208 fc0 sc0 ls17b">mais</div><div class="t m209 xaf h20d y20b ff1 fs209 fc0 sc0 ls17c">amolecidos</div><div class="t m20a x2e h20e y20c ff2 fs20a fc0 sc0 ls2">,</div><div class="t m20b x7c h20f y20d ff104 fs20b fc0 sc0 ls17d wsf6">desorganizados</div><div class="t m20c x42 h210 y20e ff2 fs20c fc0 sc0 ls2">e</div><div class="t m20d x4b h211 y20f ff105 fs20d fc0 sc0 ls17e wsf7">até</div><div class="t m20e x97 h212 y210 ff106 fs20e fc0 sc0 ls17f wsf8">líquidos</div><div class="t m20f xa h213 y211 ff107 fs20f fc0 sc0 ls180">B)</div><div class="t m210 x2d h214 y212 ff2 fs210 fc0 sc0 ls181">c.</div><div class="t m211 x79 h215 y213 ff2 fs211 fc0 sc0 ls182 wsf9">Necrose</div><div class="t m212 xb0 h216 y214 ff2 fs212 fc0 sc0 ls147 wsfa">caseira</div><div class="t m213 xcc h217 y215 ff57 fs213 fc0 sc0 ls2">\u2192</div><div class="t m214 xa6 h218 y216 ff2 fs214 fc0 sc0 ls183 wsfb">rod<span class="blank"> </span>e<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>a</div><div class="t m215 xa7 h219 y217 ff2 fs215 fc0 sc0 ls184 wsfc">por</div><div class="t m216 x10 h21a y218 ff108 fs216 fc0 sc0 ls185 wsfd">processo</div><div class="t m217 xcd h21b y219 ff109 fs217 fc0 sc0 ls148 wsfe">inflamatório</div><div class="t m218 xaf h21c y21a ff10a fs218 fc0 sc0 ls186 wsff">crônico</div><div class="t m219 x94 h21d y21b ff10b fs219 fc0 sc0 ls187">tipo</div><div class="t m21a x1d h21e y21c ff10c fs21a fc0 sc0 ls188 ws100">granulomat<span class="blank _0"></span>ose</div><div class="t m21b x9e h21f y21d ff2 fs21b fc0 sc0 ls2">-</div><div class="t m21c x89 h220 y21e ff10d fs21c fc0 sc0 ls189 ws101">macr<span class="blank _0"></span>óf<span class="blank _1"></span>agos</div><div class="t m21d xb h221 y21f ff2 fs21d fc0 sc0 ls18a">d.</div><div class="t m21e x4f h222 y220 ff2 fs21e fc0 sc0 ls18b ws102">necrose</div><div class="t m21f x87 h223 y221 ff10e fs21f fc0 sc0 ls149 ws103">gor<span class="blank _0"></span>dur<span class="blank _0"></span>osa</div><div class="t m220 x4b h224 y222 ff51 fs220 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m221 x5c h225 y223 ff10f fs221 fc0 sc0 ls18c ws104">observada</div><div class="t m222 xce h226 y224 ff2 fs222 fc0 sc0 ls18d">no</div><div class="t m223 x70 h227 y225 ff110 fs223 fc0 sc0 ls18e ws105">tecid<span class="blank _2"> </span>o</div><div class="t m224 xc5 h228 y226 ff111 fs224 fc0 sc0 ls18f ws106">adiposo</div><div class="t m225 x8 h229 y227 ff112 fs225 fc0 sc0 ls190 ws107">pr<span class="blank _0"></span>ó</div><div class="t m226 x6 h22a y228 ff2 fs226 fc0 sc0 ls2">-</div><div class="t m227 xa h22b y229 ff113 fs227 fc0 sc0 ls191">c)</div><div class="t m228 xb h22c y22a ff2 fs228 fc0 sc0 ls192 ws108">xém<span class="blank"> </span>o</div><div class="t m229 xbb h22d y22b ff2 fs229 fc0 sc0 ls193">ao</div><div class="t m22a x87 h22e y22c ff114 fs22a fc0 sc0 ls194 ws109">pâncr<span class="blank _0"></span>eas</div><div class="t m22b x9d h22f y22d ff115 fs22b fc0 sc0 ls2">(</div><div class="t m22c x88 h230 y22e ff116 fs22c fc0 sc0 ls14a ws10a">saponificação</div><div class="t m22d x53 h231 y22f ff117 fs22d fc0 sc0 ls14b ws10b">gor<span class="blank _0"></span>dur<span class="blank _0"></span>osa</div><div class="t m22e x5e h232 y230 ff118 fs22e fc0 sc0 ls2">)</div><div class="t m22f x2d h233 y231 ff2 fs22f fc0 sc0 ls195">e.</div><div class="t m230 x4f h234 y232 ff2 fs230 fc0 sc0 ls196 ws10c">necrose</div><div class="t m231 x87 h235 y233 ff119 fs231 fc0 sc0 ls197 ws10d">gangrenosa</div><div class="t m232 x77 h236 y234 ff51 fs232 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m233 xcf h237 y235 ff11a fs233 fc0 sc0 ls198 ws10e">somatória</div><div class="t m234 xd0 h238 y236 ff2 fs234 fc0 sc0 ls199">da</div><div class="t m235 xc6 h239 y237 ff2 fs235 fc0 sc0 ls14c ws10f">necrose</div><div class="t m236 x54 h23a y238 ff11b fs236 fc0 sc0 ls19a ws110">coagula</div><div class="t m237 xd1 h23b y239 ff2 fs237 fc0 sc0 ls2">-</div><div class="t m238 xb h23c y23a ff2 fs238 fc0 sc0 ls19b ws111">tive</div><div class="t m239 x62 h23d y23b ff2 fs239 fc0 sc0 ls2">e</div><div class="t m23a x1c h23e y23c ff11c fs23a fc0 sc0 ls14d ws112">lioouef<span class="blank _0"></span>álira</div><div class="t m23b x58 h23f y23d ff11d fs23b fc0 sc0 ls19c">D)</div><div class="t m23c xb1 h240 y23e ff11e fs23c fc0 sc0 ls19d">E)</div><div class="t m23d xb h241 y23f ffc fs23d fc0 sc0 ls2">\u21b3</div><div class="t m23e x76 h242 y240 ff11f fs23e fc0 sc0 ls19e ws113">Apoptose</div><div class="t m23f xb4 h243 y241 ff2 fs23f fc0 sc0 ls2">:</div><div class="t m240 x9c h244 y242 ff2 fs240 fc0 sc0 ls2">-</div><div class="t m241 x85 h245 y243 ff2 fs241 fc0 sc0 ls2">é</div><div class="t m242 xab h246 y244 ff2 fs242 fc0 sc0 ls2">o</div><div class="t m243 x23 h247 y245 ff120 fs243 fc0 sc0 ls19f">suicídio</div><div class="t m244 x92 h248 y246 ff121 fs244 fc0 sc0 ls1a0 ws114">celular</div><div class="t m245 x77 h249 y247 ff2 fs245 fc0 sc0 ls2">,</div><div class="t m246 xd2 h24a y248 ff122 fs246 fc0 sc0 ls1a1 ws115">portanto</div><div class="t m247 x3b h24b y249 ff2 fs247 fc0 sc0 ls2">é</div><div class="t m248 x3 h24c y24a ff123 fs248 fc0 sc0 ls1a2 ws116">pr<span class="blank _0"></span>ogramada</div><div class="t m249 xa5 h24d y24b ff2 fs249 fc0 sc0 ls2">,</div><div class="t m24a x8e h24e y24c ff124 fs24a fc0 sc0 ls1a3 ws117">silenciosa</div><div class="t m24b x6 h24f y24d ff2 fs24b fc0 sc0 ls2">e</div><div class="t m24c x73 h250 y24e ff2 fs24c fc0 sc0 ls1a4 ws118">não</div><div class="t m24d x37 h251 y24f ff2 fs24d fc0 sc0 ls1a5 ws119">ocorre</div><div class="t m24e xd3 h252 y250 ff2 fs24e fc0 sc0 ls2">o</div><div class="t m24f x1b h253 y251 ff125 fs24f fc0 sc0 ls1a6 ws11a">fe<span class="blank"> </span>n<span class="blank"> </span>ó<span class="blank"> </span>m<span class="blank"> </span>e<span class="blank"> </span>n<span class="blank"> </span>o</div><div class="t m250 xd4 h254 y252 ff126 fs250 fc0 sc0 ls1a7">de</div><div class="t m251 x59 h255 y253 ff127 fs251 fc0 sc0 ls1a8 ws11b">autólise</div><div class="t m252 xc0 h256 y254 ff2 fs252 fc0 sc0 ls2">.</div><div class="t m253 x88 h257 y255 ff2 fs253 fc0 sc0 ls1a9 ws11c">por</div><div class="t m254 x52 h258 y256 ff2 fs254 fc0 sc0 ls1aa ws11d">isso</div><div class="t m255 x6e h259 y257 ff2 fs255 fc0 sc0 ls1ab ws11e">não</div><div class="t m256 x6f h25a y258 ff2 fs256 fc0 sc0 ls2">é</div><div class="t m257 x32 h25b y259 ff128 fs257 fc0 sc0 ls1ac ws11f">inflamatória</div><div class="t m258 xb h25c y25a ff2 fs258 fc0 sc0 ls2">-</div><div class="t m259 xaa h25d y25b ff2 fs259 fc0 sc0 ls1ad ws120">nov<span class="blank _0"></span>a</div><div class="t m25a x94 h25e y25c ff129 fs25a fc0 sc0 ls1ae ws121">contração</div><div class="t m25b x7a h25f y25d ff2 fs25b fc0 sc0 ls2">e</div><div class="t m25c xcb h260 y25e ff12a fs25c fc0 sc0 ls1af ws122">condensação</div><div class="t m25d x66 h261 y25f ff2 fs25d fc0 sc0 ls1b0 ws123">das</div><div class="t m25e xd0 h262 y260 ff12b fs25e fc0 sc0 ls1b1 ws124">estruturas</div><div class="t m25f x95 h263 y261 ff12c fs25f fc0 sc0 ls1b2 ws125">celulares</div><div class="t m260 x2d h264 y262 ff2 fs260 fc0 sc0 ls2">-</div><div class="t m261 xc h265 y263 ff2 fs261 fc0 sc0 ls1b3 ws126">ocorre</div><div class="t m262 xca h266 y264 ff12d fs262 fc0 sc0 ls1b4 ws127">fragmentação</div><div class="t m263 x4b h267 y265 ff2 fs263 fc0 sc0 ls2">,</div><div class="t m264 xf h268 y266 ff2 fs264 fc0 sc0 ls1b5">ou</div><div class="t m265 x27 h269 y267 ff12e fs265 fc0 sc0 ls1b6 ws128">seja</div><div class="t m266 xc3 h26a y268 ff2 fs266 fc0 sc0 ls2">,</div><div class="t m267 x6e h26b y269 ff2 fs267 fc0 sc0 ls1b7 ws129">não</div><div class="t m268 xa3 h26c y26a ff12f fs268 fc0 sc0 ls1b8 ws12a">tem</div><div class="t m269 xa9 h26d y26b ff130 fs269 fc0 sc0 ls1b9 ws12b">ruptura</div><div class="t m26a xd5 h26e y26c ff2 fs26a fc0 sc0 ls1ba">da</div><div class="t m26b xd6 h26f y26d ff131 fs26b fc0 sc0 ls1bb ws12c">membrana</div><div class="t m26c x1b h270 y26e ff1 fs26c fc0 sc0 ls1bc">plasmática</div><div class="t m26d x7c h271 y26f ff2 fs26d fc0 sc0 ls2">,</div><div class="t m26e x23 h272 y270 ff132 fs26e fc0 sc0 ls1bd ws12d">seguida</div><div class="t m26f x25 h273 y271 ff2 fs26f fc0 sc0 ls1be">de</div><div class="t m270 xc7 h274 y272 ff133 fs270 fc0 sc0 ls1bf ws12e">fo<span class="blank"> </span>g<span class="blank"> </span>o<span class="blank"> </span>c<span class="blank"> </span>i<span class="blank"> </span>to<span class="blank"> </span>s<span class="blank"> </span>e</div><div class="t m271 xb1 h275 y273 ff134 fs271 fc0 sc0 ls1c0">por</div><div class="t m272 x16 h276 y274 ff135 fs272 fc0 sc0 ls1c1 ws12f">células</div><div class="t m273 x9f h277 y275 ff136 fs273 fc0 sc0 ls14e ws130">vizinhas</div><div class="t m274 x34 h278 y276 ff2 fs274 fc0 sc0 ls1c2">ou</div><div class="t m275 x19 h279 y277 ff137 fs275 fc0 sc0 ls99 ws131">por</div><div class="t m276 xc9 h27a y278 ff138 fs276 fc0 sc0 ls1c3 ws132">macr<span class="blank _0"></span>óf<span class="blank _0"></span>agos</div><div class="t m277 x2d h27b y279 ff139 fs277 fc0 sc0 ls1c4 ws133">res<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>e<span class="blank"> </span>n<span class="blank"> </span>t<span class="blank"> </span>e<span class="blank"> </span>s</div><div class="t m278 x6b h27c y27a ff2 fs278 fc0 sc0 ls2">.</div><div class="t m279 x58 h27d y27b ff13a fs279 fc0 sc0 ls1c5 ws134">Essa</div><div class="t m27a xe h27e y27c ff13b fs27a fc0 sc0 ls1c6 ws135">fragmentação</div><div class="t m27b x1f h27f y27d ff13c fs27b fc0 sc0 ls1c7 ws136">celular</div><div class="t m27c x45 h280 y27e ff13d fs27c fc0 sc0 ls1c8 ws137">fo<span class="blank"> </span>r<span class="blank"> </span>m<span class="blank"> </span>a</div><div class="t m27d xd7 h281 y27f ff2 fs27d fc0 sc0 ls1c9 ws138">corpos</div><div class="t m27e xd8 h282 y280 ff13e fs27e fc0 sc0 ls1ca ws139">apopléticos</div><div class="t m27f x2b h283 y281 ff2 fs27f fc0 sc0 ls2">,</div><div class="t m280 x37 h284 y282 ff13f fs280 fc0 sc0 ls1cb">são</div><div class="t m281 x2d h285 y283 ff2 fs281 fc0 sc0 ls14f ws13a">esses</div><div class="t m282 x62 h286 y284 ff2 fs282 fc0 sc0 ls1cc">que</div><div class="t m283 x64 h287 y285 ff2 fs283 fc0 sc0 ls1cd ws13b">serão</div><div class="t m284 x2f h288 y286 ff2 fs284 fc0 sc0 ls1ce ws13c">teog<span class="blank _2"> </span>oe<span class="blank _2"> </span>ita<span class="blank _2"> </span>do<span class="blank _2"> </span>s</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w0 hc" data-page-no="5"><div class="pc pc5 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg5.png"><div class="t m285 xb h289 y287 ff2 fs285 fc0 sc0 ls2">-</div><div class="t m286 x79 h28a y288 ff140 fs286 fc0 sc0 ls1de ws13d">elimina</div><div class="t m287 x6c h28b y289 ff141 fs287 fc0 sc0 ls1df ws13e">células</div><div class="t m288 xd9 h28c y28a ff142 fs288 fc0 sc0 ls1cf ws13f">indesejadas</div><div class="t m289 x3 h28d y28b ff143 fs289 fc0 sc0 ls1e0 ws140">seletivament<span class="blank _0"></span>e</div><div class="t m28a x29 h28e y28c ff2 fs28a fc0 sc0 ls2">,</div><div class="t m28b xc8 h28f y28d ff2 fs28b fc0 sc0 ls1e1">sem</div><div class="t m28c x5 h290 y28e ff144 fs28c fc0 sc0 ls1e2 ws141">distúrbio</div><div class="t m28d x22 h291 y28f ff145 fs28d fc0 sc0 ls1e3 ws142">celular</div><div class="t m28e xb h292 y290 ff2 fs28e fc0 sc0 ls2">-</div><div class="t m28f x85 h293 y291 ff2 fs28f fc0 sc0 ls1e4">As</div><div class="t m290 x7c h294 y292 ff2 fs290 fc0 sc0 ls1d0 ws143">causas</div><div class="t m291 xb7 h295 y293 ff146 fs291 fc0 sc0 ls1e5 ws144">podem</div><div class="t m292 x4b h296 y294 ff2 fs292 fc0 sc0 ls1e6">ser</div><div class="t m293 x97 h297 y295 ff2 fs293 fc0 sc0 ls2">:</div><div class="t m294 x2d h298 y296 ff2 fs294 fc0 sc0 ls1e7">a.</div><div class="t m295 x76 h299 y297 ff147 fs295 fc0 sc0 ls2 ws145">fisiológica</div><div class="t m296 x4a h29a y298 ff51 fs296 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m297 xad h29b y299 ff148 fs297 fc0 sc0 ls1e8 ws146">emlsriogênese</div><div class="t m298 xb3 h29c y29a ff2 fs298 fc0 sc0 ls2">(</div><div class="t m299 xb8 h29d y29b ff149 fs299 fc0 sc0 ls1e9 ws147">rnia<span class="blank _0"></span>pt<span class="blank _0"></span>og<span class="blank _0"></span>éne<span class="blank _0"></span>se</div><div class="t m29a xd7 h29e y29c ff2 fs29a fc0 sc0 ls2">,</div><div class="t m29b xd7 h29f y29d ff14a fs29b fc0 sc0 ls1ea ws148">mor<span class="blank"> </span>f<span class="blank _0"></span>ogênese</div><div class="t m29c xc9 h2a0 y29e ff14b fs29c fc0 sc0 ls2">!</div><div class="t m29d x4e h2a1 y29f ff2 fs29d fc0 sc0 ls1eb ws149">processo</div><div class="t m29e xb h2a2 y2a0 ff14c fs29e fc0 sc0 ls1ec">celular</div><div class="t m29f x86 h2a3 y2a1 ff14d fs29f fc0 sc0 ls1ed ws14a">normal</div><div class="t m2a0 x4a h2a4 y2a2 ff2 fs2a0 fc0 sc0 ls2">,</div><div class="t m2a1 x13 h2a5 y2a3 ff14e fs2a1 fc0 sc0 ls1ee ws14b">seleção</div><div class="t m2a2 x88 h2a6 y2a4 ff14f fs2a2 fc0 sc0 ls1ef ws14c">térm<span class="blank"> </span>ic<span class="blank"> </span>a</div><div class="t m2a3 x89 h2a7 y2a5 ff150 fs2a3 fc0 sc0 ls1f0 ws14d">negativa</div><div class="t m2a4 x9f h2a8 y2a6 ff2 fs2a4 fc0 sc0 ls1f1">de</div><div class="t m2a5 xb9 h2a9 y2a7 ff151 fs2a5 fc0 sc0 ls1d1 ws14e">linf<span class="blank _1"></span>ócitos</div><div class="t m2a6 x20 h2aa y2a8 ff152 fs2a6 fc0 sc0 ls2">(</div><div class="t m2a7 x5 h2ab y2a9 ff2 fs2a7 fc0 sc0 ls2">a</div><div class="t m2a8 xc9 h2ac y2aa ff153 fs2a8 fc0 sc0 ls1f2 ws14f">seleção</div><div class="t m2a9 x1b h2ad y2ab ff1 fs2a9 fc0 sc0 ls1d2 ws150">negativa</div><div class="t m2aa x2e h2ae y2ac ff154 fs2aa fc0 sc0 ls1f3 ws151">elimina</div><div class="t m2ab x6c h2af y2ad ff2 fs2ab fc0 sc0 ls1f4">os</div><div class="t m2ac xb7 h2b0 y2ae ff155 fs2ac fc0 sc0 ls1f5 ws152">linf<span class="blank _0"></span>ócit<span class="blank _0"></span>os</div><div class="t m2ad x15 h2b1 y2af ff2 fs2ad fc0 sc0 ls2">T</div><div class="t m2ae x97 h2b2 y2b0 ff2 fs2ae fc0 sc0 ls1f6">que</div><div class="t m2af x89 h2b3 y2b1 ff156 fs2af fc0 sc0 ls1f7 ws153">rea<span class="blank"> </span>g<span class="blank"> </span>e<span class="blank"> </span>m</div><div class="t m2b0 xd0 h2b4 y2b2 ff157 fs2b0 fc0 sc0 ls1f8 ws154">muito</div><div class="t m2b1 x68 h2b5 y2b3 ff158 fs2b1 fc0 sc0 ls1f9 ws155">fo<span class="blank"> </span>r<span class="blank _3"> </span>t<span class="blank"> </span>e</div><div class="t m2b2 xd5 h2b6 y2b4 ff2 fs2b2 fc0 sc0 ls1fa">com</div><div class="t m2b3 x8 h2b7 y2b5 ff2 fs2b3 fc0 sc0 ls1fb">as</div><div class="t m2b4 x6 h2b8 y2b6 ff159 fs2b4 fc0 sc0 ls1fc ws156">células</div><div class="t m2b5 x1b h2b9 y2b7 ff1 fs2b5 fc0 sc0 ls1d3 ws157">apr<span class="blank _0"></span>esent<span class="blank _0"></span>ador<span class="blank _0"></span>as</div><div class="t m2b6 x86 h2ba y2b8 ff2 fs2b6 fc0 sc0 ls1fd">do</div><div class="t m2b7 xb0 h2bb y2b9 ff2 fs2b7 fc0 sc0 ls1fe">timo</div><div class="t m2b8 x25 h2bc y2ba ff2 fs2b8 fc0 sc0 ls2">,</div><div class="t m2b9 x5b h2bd y2bb ff15a fs2b9 fc0 sc0 ls1ff ws158">atotociaidode</div><div class="t m2ba xa2 h2be y2bc ff15b fs2ba fc0 sc0 ls200 ws159">mediada</div><div class="t m2bb x32 h2bf y2bd ff15c fs2bb fc0 sc0 ls201">pela</div><div class="t m2bc xda h2c0 y2be ff15d fs2bc fc0 sc0 ls202 ws15a">célula</div><div class="t m2bd xbe h2c1 y2bf ff15e fs2bd fc0 sc0 ls2">(</div><div class="t m2be xd8 h2c2 y2c0 ff2 fs2be fc0 sc0 ls203">ou</div><div class="t m2bf xdb h2c3 y2c1 ff15f fs2bf fc0 sc0 ls204 ws15b">seja</div><div class="t m2c0 x73 h2c4 y2c2 ff2 fs2c0 fc0 sc0 ls2">,</div><div class="t m2c1 x74 h2c5 y2c3 ff160 fs2c1 fc0 sc0 ls205 ws15c">processos</div><div class="t m2c2 xdc h2c6 y2c4 ff161 fs2c2 fc0 sc0 ls206 ws15d">naturais</div><div class="t m2c3 x63 h2c7 y2c5 ff2 fs2c3 fc0 sc0 ls207">de</div><div class="t m2c4 xac h2c8 y2c6 ff162 fs2c4 fc0 sc0 ls208 ws15e">inv<span class="blank _0"></span>olução</div><div class="t m2c5 x30 h2c9 y2c7 ff2 fs2c5 fc0 sc0 ls2">e</div><div class="t m2c6 x7b h2ca y2c8 ff163 fs2c6 fc0 sc0 ls209 ws15f">desapar<span class="blank _0"></span>eciment<span class="blank _0"></span>o</div><div class="t m2c7 xdd h2cb y2c9 ff164 fs2c7 fc0 sc0 ls20a">de</div><div class="t m2c8 xa5 h2cc y2ca ff165 fs2c8 fc0 sc0 ls20b ws160">certas</div><div class="t m2c9 xde h2cd y2cb ff166 fs2c9 fc0 sc0 ls20c ws161">estruturas</div><div class="t m2ca x0 h2ce y2cc ff1 fs2ca fc0 sc0 ls1d4 ws162">anat<span class="blank _0"></span>ômicas</div><div class="t m2cb xbb h2cf y2cd ff167 fs2cb fc0 sc0 ls20d ws163">durante</div><div class="t m2cc x5a h2d0 y2ce ff2 fs2cc fc0 sc0 ls2">a</div><div class="t m2cd x7a h2d1 y2cf ff2 fs2cd fc0 sc0 ls20e">vida</div><div class="t m2ce x7e h2d2 y2d0 ff168 fs2ce fc0 sc0 ls20f">do</div><div class="t m2cf x9e h2d3 y2d1 ff169 fs2cf fc0 sc0 ls1d5 ws164">or<span class="blank _0"></span>ganismo</div><div class="t m2d0 x45 h2d4 y2d2 ff2 fs2d0 fc0 sc0 ls2">e</div><div class="t m2d1 x33 h2d5 y2d3 ff2 fs2d1 fc0 sc0 ls210 ws165">para</div><div class="t m2d2 x5e h2d6 y2d4 ff16a fs2d2 fc0 sc0 ls1d6 ws166">equilíbrio</div><div class="t m2d3 x7 h2d7 y2d5 ff16b fs2d3 fc0 sc0 ls211 ws167">interno</div><div class="t m2d4 x2c h2d8 y2d6 ff16c fs2d4 fc0 sc0 ls212">do</div><div class="t m2d5 x1b h2d9 y2d7 ff16d fs2d5 fc0 sc0 ls1d7 ws168">or<span class="blank _0"></span>ganismo</div><div class="t m2d6 xb0 h2da y2d8 ff16e fs2d6 fc0 sc0 ls2">)</div><div class="t m2d7 xb h2db y2d9 ff16f fs2d7 fc0 sc0 ls213">b.</div><div class="t m2d8 x76 h2dc y2da ff170 fs2d8 fc0 sc0 ls214 ws169">patológica</div><div class="t m2d9 xb2 h2dd y2db ff51 fs2d9 fc0 sc0 ls2">\udb8b\udc1b</div><div class="t m2da x5b h2de y2dc ff2 fs2da fc0 sc0 ls215 ws16a">dano</div><div class="t m2db x15 h2df y2dd ff2 fs2db fc0 sc0 ls216">ao</div><div class="t m2dc x27 h2e0 y2de ff2 fs2dc fc0 sc0 ls217 ws16b">DNA</div><div class="t m2dd x6e h2e1 y2df ff2 fs2dd fc0 sc0 ls2">(</div><div class="t m2de xb8 h2e2 y2e0 ff171 fs2de fc0 sc0 ls218 ws16c">devido</div><div class="t m2df xdf h2e3 y2e1 ff2 fs2df fc0 sc0 ls2">à</div><div class="t m2e0 x98 h2e4 y2e2 ff172 fs2e0 fc0 sc0 ls219 ws16d">hipóáa</div><div class="t m2e1 x95 h2e5 y2e3 ff2 fs2e1 fc0 sc0 ls2">,</div><div class="t m2e2 xd5 h2e6 y2e4 ff2 fs2e2 fc0 sc0 ls2">à</div><div class="t m2e3 xe0 h2e7 y2e5 ff173 fs2e3 fc0 sc0 ls21a ws16e">radia<span class="blank _2"> </span>ção</div><div class="t m2e4 xbf h2e8 y2e6 ff2 fs2e4 fc0 sc0 ls21b">ou</div><div class="t m2e5 x8f h2e9 y2e7 ff2 fs2e5 fc0 sc0 ls2">a</div><div class="t m2e6 xaf h2ea y2e8 ff174 fs2e6 fc0 sc0 ls21c ws16f">fár<span class="blank _2"> </span>m<span class="blank"> </span>a<span class="blank"> </span>c<span class="blank _2"> </span>o<span class="blank"> </span>s</div><div class="t m2e7 xb4 h2eb y2e9 ff175 fs2e7 fc0 sc0 ls21d ws170">ietdoáios</div><div class="t m2e8 xe1 h2ec y2ea ff176 fs2e8 fc0 sc0 ls2">)</div><div class="t m2e9 xc0 h2ed y2eb ff2 fs2e9 fc0 sc0 ls2">,</div><div class="t m2ea xe2 h2ee y2ec ff177 fs2ea fc0 sc0 ls21e ws171">acúmulo</div><div class="t m2eb x3b h2ef y2ed ff2 fs2eb fc0 sc0 ls21f">de</div><div class="t m2ec x10 h2f0 y2ee ff178 fs2ec fc0 sc0 ls220 ws172">pr<span class="blank _0"></span>oteínas</div><div class="t m2ed xe3 h2f1 y2ef ff2 fs2ed fc0 sc0 ls221">mal</div><div class="t m2ee xbe h2f2 y2f0 ff179 fs2ee fc0 sc0 ls222 ws173">dobradas</div><div class="t m2ef x96 h2f3 y2f1 ff2 fs2ef fc0 sc0 ls2">,</div><div class="t m2f0 xe4 h2f4 y2f2 ff17a fs2f0 fc0 sc0 ls223">ação</div><div class="t m2f1 x90 h2f5 y2f3 ff17b fs2f1 fc0 sc0 ls224">dos</div><div class="t m2f2 xb h2f6 y2f4 ff17c fs2f2 fc0 sc0 ls2 ws174">linf<span class="blank _1"></span>ócitos</div><div class="t m2f3 x7d h2f7 y2f5 ff2 fs2f3 fc0 sc0 ls2">t</div><div class="t m2f4 x58 h2f8 y2f6 ff17d fs2f4 fc0 sc0 ls225 ws175">àtdóãios</div><div class="t m2f5 x9d h2f9 y2f7 ff2 fs2f5 fc0 sc0 ls226">em</div><div class="t m2f6 x1e h2fa y2f8 ff17e fs2f6 fc0 sc0 ls227 ws176">inf<span class="blank _0"></span>ecções</div><div class="t m2f7 x3 h2fb y2f9 ff17f fs2f7 fc0 sc0 ls228 ws177">virais</div><div class="t m2f8 xa9 h2fc y2fa ff2 fs2f8 fc0 sc0 ls2">e</div><div class="t m2f9 xb9 h2fd y2fb ff2 fs2f9 fc0 sc0 ls229 ws178">tumores</div><div class="t m2fa xe5 h2fe y2fc ff2 fs2fa fc0 sc0 ls2">(</div><div class="t m2fb x99 h2ff y2fd ff2 fs2fb fc0 sc0 ls22a">uma</div><div class="t m2fc xa h300 y2fe ff180 fs2fc fc0 sc0 ls22b ws179">célula</div><div class="t m2fd xe6 h301 y2ff ff2 fs2fd fc0 sc0 ls22c">leão</div><div class="t m2fe xe7 h302 y300 ff2 fs2fe fc0 sc0 ls2">.</div><div class="t m2ff xe8 h303 y301 ff2 fs2ff fc0 sc0 ls22d ws17a">nada</div><div class="t m300 x7c h304 y302 ff2 fs300 fc0 sc0 ls22e ws17b">vai</div><div class="t m301 xb4 h305 y303 ff181 fs301 fc0 sc0 ls22f">para</div><div class="t m302 x65 h306 y304 ff182 fs302 fc0 sc0 ls230 ws17c">apoptose</div><div class="t m303 x27 h307 y305 ff2 fs303 fc0 sc0 ls2">a</div><div class="t m304 x9e h308 y306 ff183 fs304 fc0 sc0 ls231">fim</div><div class="t m305 x66 h309 y307 ff2 fs305 fc0 sc0 ls232">de</div><div class="t m306 x3d h30a y308 ff184 fs306 fc0 sc0 ls233 ws17d">evit<span class="blank _2"> </span>ar</div><div class="t m307 xcd h30b y309 ff185 fs307 fc0 sc0 ls234 ws17e">danos</div><div class="t m308 xe5 h30c y30a ff186 fs308 fc0 sc0 ls235 ws17f">patológicos</div><div class="t m309 xbf h30d y30b ff187 fs309 fc0 sc0 ls236 ws180">futuros</div><div class="t m30a x1a h30e y30c ff2 fs30a fc0 sc0 ls2">,</div><div class="t m30b xe8 h30f y30d ff2 fs30b fc0 sc0 ls237 ws181">como</div><div class="t m30c x62 h310 y30e ff188 fs30c fc0 sc0 ls238">câncer</div><div class="t m30d xac h311 y30f ff189 fs30d fc0 sc0 ls2">)</div><div class="t m30e x1d h312 y310 ff2 fs30e fc0 sc0 ls2">,</div><div class="t m30f xe9 h313 y311 ff18a fs30f fc0 sc0 ls239 ws182">toni<span class="blank _2"> </span>cida<span class="blank _2"> </span>de</div><div class="t m310 x51 h314 y312 ff2 fs310 fc0 sc0 ls2">,</div><div class="t m311 x1e h315 y313 ff18b fs311 fc0 sc0 ls1d8 ws183">radiot<span class="blank _0"></span>erapia</div><div class="t m312 xea h316 y314 ff2 fs312 fc0 sc0 ls2">,</div><div class="t m313 xdf h317 y315 ff18c fs313 fc0 sc0 ls23a">radicais</div><div class="t m314 x2a h318 y316 ff18d fs314 fc0 sc0 ls23b ws184">livres</div><div class="t m315 xeb h319 y317 ff2 fs315 fc0 sc0 ls2">,</div><div class="t m316 x9a h31a y318 ff2 fs316 fc0 sc0 ls23c ws185">vírus</div><div class="t m317 x36 h31b y319 ff2 fs317 fc0 sc0 ls2">e</div><div class="t m318 xbf h31c y31a ff1 fs318 fc0 sc0 ls1d9 ws186">tipóia</div><div class="t m319 xb h31d y31b ff2 fs319 fc0 sc0 ls2">-</div><div class="t m31a x49 h31e y31c ff2 fs31a fc0 sc0 ls23d ws187">mecanismo</div><div class="t m31b x41 h31f y31d ff2 fs31b fc0 sc0 ls2">:</div><div class="t m31c xb h320 y31e ffc fs31c fc0 sc0 ls2">\u21b3</div><div class="t m31d x57 h321 y31f ff2 fs31d fc0 sc0 ls2">a</div><div class="t m31e xbc h322 y320 ff18e fs31e fc0 sc0 ls23e ws188">apoptose</div><div class="t m31f xb7 h323 y321 ff18f fs31f fc0 sc0 ls23f ws189">depende</div><div class="t m320 x7e h324 y322 ff190 fs320 fc0 sc0 ls240">da</div><div class="t m321 xa2 h325 y323 ff191 fs321 fc0 sc0 ls1da ws18a">ativação</div><div class="t m322 xec h326 y324 ff2 fs322 fc0 sc0 ls241">de</div><div class="t m323 x46 h327 y325 ff192 fs323 fc0 sc0 ls242 ws18b">carpas</div><div class="t m324 xde h328 y326 ff2 fs324 fc0 sc0 ls2">,</div><div class="t m325 xed h329 y327 ff2 fs325 fc0 sc0 ls1db ws18c">essas</div><div class="t m326 xa h32a y328 ff2 fs326 fc0 sc0 ls243 ws18d">são</div><div class="t m327 x2d h32b y329 ff1 fs327 fc0 sc0 ls1dc ws18e">enzimas</div><div class="t m328 x2e h32c y32a ff193 fs328 fc0 sc0 ls244">que</div><div class="t m329 x7d h32d y32b ff194 fs329 fc0 sc0 ls245 ws18f">possuem</div><div class="t m32a x7a h32e y32c ff195 fs32a fc0 sc0 ls246 ws190">cisterna</div><div class="t m32b x7b h32f y32d ff2 fs32b fc0 sc0 ls247">no</div><div class="t m32c xee h330 y32e ff196 fs32c fc0 sc0 ls248">sítio</div><div class="t m32d xef h331 y32f ff2 fs32d fc0 sc0 ls249 ws191">ativo</div><div class="t m32e xc6 h332 y330 ff2 fs32e fc0 sc0 ls2">e</div><div class="t m32f xe3 h333 y331 ff2 fs32f fc0 sc0 ls24a">que</div><div class="t m330 xc8 h334 y332 ff197 fs330 fc0 sc0 ls24b">leiam</div><div class="t m331 xc9 h335 y333 ff198 fs331 fc0 sc0 ls24c ws192">pr<span class="blank _0"></span>oteínas</div><div class="t m332 x9b h336 y334 ff2 fs332 fc0 sc0 ls24d">em</div><div class="t m333 x1b h337 y335 ff199 fs333 fc0 sc0 ls24e ws193">sítios</div><div class="t m334 xbc h338 y336 ff2 fs334 fc0 sc0 ls24f">com</div><div class="t m335 x6b h339 y337 ff19a fs335 fc0 sc0 ls250 ws194">res<span class="blank"> </span>í<span class="blank"> </span>d<span class="blank"> </span>u<span class="blank"> </span>o<span class="blank"> </span>s</div><div class="t m336 x14 h33a y338 ff2 fs336 fc0 sc0 ls251">de</div><div class="t m337 x15 h33b y339 ff2 fs337 fc0 sc0 ls252 ws195">ácido</div><div class="t m338 x78 h33c y33a ff19b fs338 fc0 sc0 ls253 ws196">aspártico</div><div class="t m339 xea h33d y33b ff2 fs339 fc0 sc0 ls2">.</div><div class="t m33a x8a h33e y33c ff19c fs33a fc0 sc0 ls254 ws197">Além</div><div class="t m33b x5e h33f y33d ff19d fs33b fc0 sc0 ls255 ws198">disso</div><div class="t m33c xf0 h340 y33e ff2 fs33c fc0 sc0 ls2">,</div><div class="t m33d xed h341 y33f ff2 fs33d fc0 sc0 ls256 ws199">compares</div><div class="t m33e x56 h342 y340 ff19e fs33e fc0 sc0 ls257 ws19a">ativam</div><div class="t m33f xb h343 y341 ff19f fs33f fc0 sc0 ls258">outras</div><div class="t m340 x23 h344 y342 ff1a0 fs340 fc0 sc0 ls259 ws19b">prot<span class="blank _0"></span>eases</div><div class="t m341 x5b h345 y343 ff1a1 fs341 fc0 sc0 ls25a ws19c">res<span class="blank"> </span>p<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>á<span class="blank"> </span>vei<span class="blank"> </span>s</div><div class="t m342 x78 h346 y344 ff1a2 fs342 fc0 sc0 ls25b">pela</div><div class="t m343 x3 h347 y345 ff1a3 fs343 fc0 sc0 ls2 ws19d">degradação</div><div class="t m344 x11 h348 y346 ff1a4 fs344 fc0 sc0 ls25c">de</div><div class="t m345 x54 h349 y347 ff2 fs345 fc0 sc0 ls25d ws19e">DNA</div><div class="t m346 x5 h34a y348 ff2 fs346 fc0 sc0 ls2">,</div><div class="t m347 xf1 h34b y349 ff1a5 fs347 fc0 sc0 ls25e ws19f">laminas</div><div class="t m348 x2d h34c y34a ff1 fs348 fc0 sc0 ls1dd ws1a0">nuclear<span class="blank _1"></span>es</div><div class="t m349 x76 h34d y34b ff2 fs349 fc0 sc0 ls2">e</div><div class="t m34a xba h34e y34c ff1a6 fs34a fc0 sc0 ls25f ws1a1">pr<span class="blank _0"></span>oteínas</div><div class="t m34b x8c h34f y34d ff2 fs34b fc0 sc0 ls260">do</div><div class="t m34c xad h350 y34e ff1a7 fs34c fc0 sc0 ls261 ws1a2">citoesquelet<span class="blank _0"></span>o</div><div class="t m34d xf2 h351 y34f ff2 fs34d fc0 sc0 ls2">,</div><div class="t m34e x89 h352 y350 ff1a8 fs34e fc0 sc0 ls2 ws1a3">r<span class="blank _0"></span>esultando</div><div class="t m34f x98 h353 y351 ff2 fs34f fc0 sc0 ls262">em</div><div class="t m350 x71 h354 y352 ff1a9 fs350 fc0 sc0 ls263 ws1a4">modificações</div><div class="t m351 x55 h355 y353 ff1aa fs351 fc0 sc0 ls264 ws1a5">mor<span class="blank"> </span>f<span class="blank _1"></span>ológicas</div><div class="t m352 xe8 h356 y354 ff2 fs352 fc0 sc0 ls265">da</div><div class="t m353 xf3 h357 y355 ff1ab fs353 fc0 sc0 ls266 ws1a6">apoptose</div><div class="t m354 xc2 h358 y356 ff2 fs354 fc0 sc0 ls2">.</div><div class="t m355 xaf h359 y357 ffc fs355 fc0 sc0 ls2">\u21b3</div><div class="t m356 xf3 h35a y358 ff1ac fs356 fc0 sc0 ls267 ws1a7">apoptose</div><div class="t m357 x6c h35b y359 ff1ad fs357 fc0 sc0 ls268">depende</div><div class="t m358 xd9 h35c y35a ff2 fs358 fc0 sc0 ls269">de</div><div class="t m359 x7e h35d y35b ff1ae fs359 fc0 sc0 ls26a">duas</div><div class="t m35a x3b h35e y35c ff1af fs35a fc0 sc0 ls26b ws1a8">vias</div><div class="t m35b x53 h35f y35d ff2 fs35b fc0 sc0 ls2">,</div><div class="t m35c xea h360 y35e ff1b0 fs35c fc0 sc0 ls26c">elas</div><div class="t m35d xe3 h361 y35f ff2 fs35d fc0 sc0 ls26d">que</div><div class="t m35e xc8 h362 y360 ff2 fs35e fc0 sc0 ls26e ws1a9">vão</div><div class="t m35f x20 h363 y361 ff1b1 fs35f fc0 sc0 ls26f ws1aa">ativar</div><div class="t m360 x35 h364 y362 ff2 fs360 fc0 sc0 ls270">as</div><div class="t m361 x56 h365 y363 ff2 fs361 fc0 sc0 ls271 ws1ab">caspases</div><div class="t m362 x1c h366 y364 ff2 fs362 fc0 sc0 ls2">/</div><div class="t m363 x24 h367 y365 ff1b2 fs363 fc0 sc0 ls272 ws1ac">mitocondrial</div><div class="t m364 x83 h368 y366 ff2 fs364 fc0 sc0 ls2">)</div><div class="t m365 xf4 h369 y367 ff1b3 fs365 fc0 sc0 ls2">µ</div><div class="t m366 xc5 h36a y368 ff1b4 fs366 fc0 sc0 ls273 ws1ad">desencadeada</div><div class="t m367 x47 h36b y369 ff1b5 fs367 fc0 sc0 ls274 ws1ae">pela</div><div class="t m368 xf5 h36c y36a ff1b6 fs368 fc0 sc0 ls275">ligação</div><div class="t m369 xf6 h36d y36b ff2 fs369 fc0 sc0 ls276">de</div><div class="t m36a xf7 h36e y36c ff1b7 fs36a fc0 sc0 ls277 ws1af">Via</div><div class="t m36b x8e h36f y36d ff1b8 fs36b fc0 sc0 ls278 ws1b0">eãbunseca</div><div class="t m36c xf8 h370 y36e ff1b9 fs36c fc0 sc0 ls279 ws1b1">moléculas</div><div class="t m36d xe6 h371 y36f ff2 fs36d fc0 sc0 ls27a">aos</div><div class="t m36e x62 h372 y370 ff2 fs36e fc0 sc0 ls27b">Via</div><div class="t m36f x87 h373 y371 ff1ba fs36f fc0 sc0 ls27c">intrínseca</div><div class="t m370 x96 h374 y372 ff2 fs370 fc0 sc0 ls27d ws1b2">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m371 x49 h375 y373 ff1bb fs371 fc0 sc0 ls27e ws1b3">aumento</div><div class="t m372 x63 h376 y374 ff2 fs372 fc0 sc0 ls27f">da</div><div class="t m373 xac h377 y375 ff1bc fs373 fc0 sc0 ls280 ws1b4">permeabilidade</div><div class="t m374 x98 h378 y376 ff2 fs374 fc0 sc0 ls281 ws1b5">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m375 xd5 h379 y377 ff2 fs375 fc0 sc0 ls282">de</div><div class="t m376 xd8 h37a y378 ff2 fs376 fc0 sc0 ls283 ws1b6">mor<span class="blank"> </span>te</div><div class="t m377 xd1 h37b y379 ff2 fs377 fc0 sc0 ls284">na</div><div class="t m378 x4e h37c y37a ff1bd fs378 fc0 sc0 ls285 ws1b7">membrana</div><div class="t m379 xc h37d y37b ff1be fs379 fc0 sc0 ls286 ws1b8">intracelular</div><div class="t m37a x4a h37e y37c ff2 fs37a fc0 sc0 ls2">.</div><div class="t m37b xe9 h37f y37d ff1bf fs37b fc0 sc0 ls287 ws1b9">controle</div><div class="t m37c x4b h380 y37e ff2 fs37c fc0 sc0 ls2">:</div><div class="t m37d x13 h381 y37f ff2 fs37d fc0 sc0 ls288 ws1ba">proteínas</div><div class="t m37e xc6 h382 y380 ff2 fs37e fc0 sc0 ls289 ws1bb">ulular</div><div class="t m37f xbe h383 y381 ff2 fs37f fc0 sc0 ls28a">se</div><div class="t m380 xde h384 y382 ff1c0 fs380 fc0 sc0 ls28b">liga</div><div class="t m381 x9a h385 y383 ff2 fs381 fc0 sc0 ls28c">ao</div><div class="t m382 xf9 h386 y384 ff2 fs382 fc0 sc0 ls28d ws1bc">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>r</div><div class="t m383 x69 h387 y385 ff2 fs383 fc0 sc0 ls28e ws1bd">fãs</div><div class="t m384 x79 h388 y386 ff2 fs384 fc0 sc0 ls2">-</div><div class="t m385 x57 h389 y387 ff1c1 fs385 fc0 sc0 ls28f ws1be">fa<span class="blank"> </span>m<span class="blank"> </span>í<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>a</div><div class="t m386 x87 h38a y388 ff1c2 fs386 fc0 sc0 ls290">Bd</div><div class="t m387 x1d h38b y389 ff57 fs387 fc0 sc0 ls2">\u2192</div><div class="t m388 x8b h38c y38a ff1c3 fs388 fc0 sc0 ls291 ws1bf">intracelular</div><div class="t m389 x98 h38d y38b ff2 fs389 fc0 sc0 ls2">-</div><div class="t m38a xfa h38e y38c ff2 fs38a fc0 sc0 ls292 ws1c0">Fa<span class="blank"> </span>s</div><div class="t m38b xfb h38f y38d ff2 fs38b fc0 sc0 ls2">L</div><div class="t m38c x72 h390 y38e ff57 fs38c fc0 sc0 ls2">\u2192</div><div class="t m38d xbe h391 y38f ff1c4 fs38d fc0 sc0 ls293 ws1c1">ligante</div><div class="t m38e x6 h392 y390 ff2 fs38e fc0 sc0 ls294 ws1c2">vol<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>o</div><div class="t m38f xfc h393 y391 ff2 fs38f fc0 sc0 ls295 ws1c3">para</div><div class="t m390 x9b h394 y392 ff2 fs390 fc0 sc0 ls2">o</div><div class="t m391 x49 h395 y393 ff2 fs391 fc0 sc0 ls2">-</div><div class="t m392 x57 h396 y394 ff1c5 fs392 fc0 sc0 ls296 ws1c4">prot<span class="blank _0"></span>eínas</div><div class="t m393 x80 h397 y395 ff2 fs393 fc0 sc0 ls297 ws1c5">sensoras</div><div class="t m394 x98 h398 y396 ff2 fs394 fc0 sc0 ls2">-</div><div class="t m395 xa4 h399 y397 ff2 fs395 fc0 sc0 ls298 ws1c6">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>r</div><div class="t m396 xd5 h39a y398 ff2 fs396 fc0 sc0 ls299">de</div><div class="t m397 xde h39b y399 ff2 fs397 fc0 sc0 ls29a">TNF</div><div class="t m398 x47 h39c y39a ff2 fs398 fc0 sc0 ls29b">meio</div><div class="t m399 xf5 h39d y39b ff2 fs399 fc0 sc0 ls29c ws1c7">atrasada</div><div class="t m39a x61 h39e y39c ffc fs39a fc0 sc0 ls2">\u21b3</div><div class="t m39b x7c h39f y39d ff1c6 fs39b fc0 sc0 ls29d ws1c8">detecta</div><div class="t m39c x59 h3a0 y39e ff2 fs39c fc0 sc0 ls29e ws1c9">erros</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w0 hc" data-page-no="6"><div class="pc pc6 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg6.png"><div class="t m39d xb h3a1 y39f ff2 fs39d fc0 sc0 ls2a6">a.</div><div class="t m39e x79 h3a2 y3a0 ff2 fs39e fc0 sc0 ls2a7">Nia</div><div class="t m39f xbb h3a3 y3a1 ff1c7 fs39f fc0 sc0 ls2a8 ws1ca">intrínseca</div><div class="t m3a0 x5b h3a4 y3a2 ff2 fs3a0 fc0 sc0 ls2">:</div><div class="t m3a1 x68 h3a5 y3a3 ff1c8 fs3a1 fc0 sc0 ls2">\u2461</div><div class="t m3a2 xb h3a6 y3a4 ffc fs3a2 fc0 sc0 ls2">\u21b3</div><div class="t m3a3 x76 h3a7 y3a5 ff2 fs3a3 fc0 sc0 ls2">é</div><div class="t m3a4 xba h3a8 y3a6 ff2 fs3a4 fc0 sc0 ls2">o</div><div class="t m3a5 x7c h3a9 y3a7 ff1c9 fs3a5 fc0 sc0 ls29f ws1cb">equilibrio</div><div class="t m3a6 x7a h3aa y3a8 ff1ca fs3a6 fc0 sc0 ls2a9 ws1cc">entre</div><div class="t m3a7 xd2 h3ab y3a9 ff2 fs3a7 fc0 sc0 ls2aa">as</div><div class="t m3a8 xfd h3ac y3aa ff1cb fs3a8 fc0 sc0 ls2">\u2462</div><div class="t m3a9 x0 h3ad y3ab ff1cc fs3a9 fc0 sc0 ls2ab ws1cd">moléculas</div><div class="t m3aa xb0 h3ae y3ac ff1cd fs3aa fc0 sc0 ls2ac ws1ce">pr<span class="blank _0"></span>oapoptólícas</div><div class="t m3ab x51 h3af y3ad ff2 fs3ab fc0 sc0 ls2">e</div><div class="t m3ac x2d h3b0 y3ae ff1ce fs3ac fc0 sc0 ls2ad ws1cf">antiapoptótieas</div><div class="t m3ad x5a h3b1 y3af ff2 fs3ad fc0 sc0 ls2ae">que</div><div class="t m3ae xb3 h3b2 y3b0 ff1cf fs3ae fc0 sc0 ls2">\u2466</div><div class="t m3af xb h3b3 y3b1 ff1d0 fs3af fc0 sc0 ls2a0 ws1d0">r<span class="blank _0"></span>egulam<span class="blank _4"></span></div><div class="t m3b0 xd4 h3b4 y3b2 ff2 fs3b0 fc0 sc0 ls2">a</div><div class="t m3b1 xb2 h3b5 y3b3 ff1d1 fs3b1 fc0 sc0 ls2af ws1d1">permeabilidade</div><div class="t m3b2 x1b h3b6 y3b4 ff1d2 fs3b2 fc0 sc0 ls2b0 ws1d2">mitocondrial</div><div class="t m3b3 x58 h3b7 y3b5 ff2 fs3b3 fc0 sc0 ls2">.</div><div class="t m3b4 xb h3b8 y3b6 ffc fs3b4 fc0 sc0 ls2">\u21b3</div><div class="t m3b5 x4f h3b9 y3b7 ff1d3 fs3b5 fc0 sc0 ls2b1 ws1d3">pr<span class="blank _0"></span>oteínas</div><div class="t m3b6 x59 h3ba y3b8 ff1d4 fs3b6 fc0 sc0 ls2b2 ws1d4">antiapoptóticas</div><div class="t m3b7 xfe h3bb y3b9 ff2 fs3b7 fc0 sc0 ls2">:</div><div class="t m3b8 xff h3bc y3ba ff1d5 fs3b8 fc0 sc0 ls2">\u2460</div><div class="t m3b9 x2d h3bd y3bb ff1d6 fs3b9 fc0 sc0 ls2b3">Bel</div><div class="t m3ba x4f h3be y3bc ff2 fs3ba fc0 sc0 ls2b4">-2</div><div class="t m3bb xbc h3bf y3bd ff2 fs3bb fc0 sc0 ls2">,</div><div class="t m3bc xbb h3c0 y3be ff1d7 fs3bc fc0 sc0 ls2b5">Bd</div><div class="t m3bd x6b h3c1 y3bf ff2 fs3bd fc0 sc0 ls2">-</div><div class="t m3be xb4 h3c2 y3c0 ff2 fs3be fc0 sc0 ls2">*</div><div class="t m3bf x6c h3c3 y3c1 ff2 fs3bf fc0 sc0 ls2">L</div><div class="t m3c0 x50 h3c4 y3c2 ff1d8 fs3c0 fc0 sc0 ls2">(</div><div class="t m3c1 x13 h3c5 y3c3 ff1d9 fs3c1 fc0 sc0 ls2b6 ws1d5">inibem</div><div class="t m3c2 xf h3c6 y3c4 ff1da fs3c2 fc0 sc0 ls2b7">Bar</div><div class="t m3c3 xb5 h3c7 y3c5 ff2 fs3c3 fc0 sc0 ls2">e</div><div class="t m3c4 xb h3c8 y3c6 ff2 fs3c4 fc0 sc0 ls2b8">Bak</div><div class="t m3c5 x100 h3c9 y3c7 ff2 fs3c5 fc0 sc0 ls2">e</div><div class="t m3c6 x94 h3ca y3c8 ff1db fs3c6 fc0 sc0 ls2b9 ws1d6">sequestram</div><div class="t m3c7 xcb h3cb y3c9 ff2 fs3c7 fc0 sc0 ls2">o</div><div class="t m3c8 x4b h3cc y3ca ff1dc fs3c8 fc0 sc0 ls2ba ws1d7">citocromo</div><div class="t m3c9 xb1 h3cd y3cb ff2 fs3c9 fc0 sc0 ls2bb">c)</div><div class="t m3ca x2d h3ce y3cc ffc fs3ca fc0 sc0 ls2">\u21b3</div><div class="t m3cb x76 h3cf y3cd ff1dd fs3cb fc0 sc0 ls2bc ws1d8">pr<span class="blank _0"></span>oteínas</div><div class="t m3cc x80 h3d0 y3ce ff1de fs3cc fc0 sc0 ls2bd ws1d9">pro<span class="blank _0"></span>apoptot<span class="blank _4"></span>eias</div><div class="t m3cd x7e h3d1 y3cf ff2 fs3cd fc0 sc0 ls2">:</div><div class="t m3ce x52 h3d2 y3d0 ff2 fs3ce fc0 sc0 ls2be">Boa</div><div class="t m3cf xb h3d3 y3d1 ff2 fs3cf fc0 sc0 ls2">e</div><div class="t m3d0 x4f h3d4 y3d2 ff1df fs3d0 fc0 sc0 ls2bf">Bok</div><div class="t m3d1 x1b h3d5 y3d3 ffc fs3d1 fc0 sc0 ls2">\u21b3</div><div class="t m3d2 x79 h3d6 y3d4 ff1e0 fs3d2 fc0 sc0 ls2c0 ws1da">pr<span class="blank _4"></span>oteínas</div><div class="t m3d3 x58 h3d7 y3d5 ff2 fs3d3 fc0 sc0 ls2c1 ws1db">sensoras</div><div class="t m3d4 xe2 h3d8 y3d6 ff2 fs3d4 fc0 sc0 ls2">:</div><div class="t m3d5 x51 h3d9 y3d7 ff2 fs3d5 fc0 sc0 ls2c2">BH</div><div class="t m3d6 x27 h3da y3d8 ff2 fs3d6 fc0 sc0 ls2">3</div><div class="t m3d7 x44 h3db y3d9 ff2 fs3d7 fc0 sc0 ls2">=</div><div class="t m3d8 x4d h3dc y3da ff2 fs3d8 fc0 sc0 ls2c3">Bim</div><div class="t m3d9 x101 h3dd y3db ff2 fs3d9 fc0 sc0 ls2">,</div><div class="t m3da x102 h3de y3dc ff2 fs3da fc0 sc0 ls2c4">Bad</div><div class="t m3db x98 h3df y3dd ff2 fs3db fc0 sc0 ls2">,</div><div class="t m3dc x46 h3e0 y3de ff2 fs3dc fc0 sc0 ls2c5">Bid</div><div class="t m3dd x2d h3e1 y3df ffc fs3dd fc0 sc0 ls2">\u21b3</div><div class="t m3de x76 h3e2 y3e0 ff1e1 fs3de fc0 sc0 ls2c6 ws1dc">ext<span class="blank"> </span>r<span class="blank"> </span>ava<span class="blank"> </span>s<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>e<span class="blank"> </span>n<span class="blank"> </span>t<span class="blank"> </span>o</div><div class="t m3df x14 h3e3 y3e1 ff2 fs3df fc0 sc0 ls2c7">do</div><div class="t m3e0 x103 h3e4 y3e2 ff1e2 fs3e0 fc0 sc0 ls2c8 ws1dd">citocr<span class="blank _0"></span>omo</div><div class="t m3e1 xff h3e5 y3e3 ff2 fs3e1 fc0 sc0 ls2">C</div><div class="t m3e2 xa8 h3e6 y3e4 ff2 fs3e2 fc0 sc0 ls2">e</div><div class="t m3e3 x53 h3e7 y3e5 ff1e3 fs3e3 fc0 sc0 ls2c9 ws1de">fat<span class="blank"> </span>o<span class="blank"> </span>r</div><div class="t m3e4 xb9 h3e8 y3e6 ff1e4 fs3e4 fc0 sc0 ls2ca">de</div><div class="t m3e5 xc5 h3e9 y3e7 ff1e5 fs3e5 fc0 sc0 ls2a1 ws1df">ativação</div><div class="t m3e6 xc9 h3ea y3e8 ff1e6 fs3e6 fc0 sc0 ls15c">da</div><div class="t m3e7 x35 h3eb y3e9 ff1e7 fs3e7 fc0 sc0 ls2cb ws1e0">apoptose</div><div class="t m3e8 x90 h3ec y3ea ff2 fs3e8 fc0 sc0 ls2">a</div><div class="t m3e9 xaf h3ed y3eb ff2 fs3e9 fc0 sc0 ls2">(</div><div class="t m3ea xaa h3ee y3ec ff2 fs3ea fc0 sc0 ls2cc">Air</div><div class="t m3eb xba h3ef y3ed ff2 fs3eb fc0 sc0 ls2">)</div><div class="t m3ec x39 h3f0 y3ee ff1e8 fs3ec fc0 sc0 ls2cd">são</div><div class="t m3ed x41 h3f1 y3ef ff1e9 fs3ed fc0 sc0 ls2ce ws1e1">res<span class="blank"> </span>p<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>á<span class="blank"> </span>ve<span class="blank"> </span>i<span class="blank"> </span>s</div><div class="t m3ee x7b h3f2 y3f0 ff1ea fs3ee fc0 sc0 ls2cf ws1e2">pela</div><div class="t m3ef x3b h3f3 y3f1 ff1eb fs3ef fc0 sc0 ls2a2 ws1e3">ativação</div><div class="t m3f0 x33 h3f4 y3f2 ff1ec fs3f0 fc0 sc0 ls2d0 ws1e4">das</div><div class="t m3f1 xfb h3f5 y3f3 ff2 fs3f1 fc0 sc0 ls2d1 ws1e5">caapases</div><div class="t m3f2 x104 h3f6 y3f4 ff2 fs3f2 fc0 sc0 ls2">(</div><div class="t m3f3 x55 h3f7 y3f5 ff2 fs3f3 fc0 sc0 ls2d2 ws1e6">Caspar</div><div class="t m3f4 x75 h3f8 y3f6 ff2 fs3f4 fc0 sc0 ls2">8</div><div class="t m3f5 x2d h3f9 y3f7 ff2 fs3f5 fc0 sc0 ls2d3 ws1e7">inicia</div><div class="t m3f6 xbb h3fa y3f8 ff2 fs3f6 fc0 sc0 ls2">a</div><div class="t m3f7 xca h3fb y3f9 ff2 fs3f7 fc0 sc0 ls2d4">via</div><div class="t m3f8 x4a h3fc y3fa ff1ed fs3f8 fc0 sc0 ls2d5 ws1e8">wc<span class="blank"> </span>t<span class="blank"> </span>rón<span class="blank"> </span>s<span class="blank"> </span>i<span class="blank"> </span>c<span class="blank"> </span>a</div><div class="t m3f9 x7e h3fd y3fb ff2 fs3f9 fc0 sc0 ls2">e</div><div class="t m3fa x43 h3fe y3fc ff2 fs3fa fc0 sc0 ls2d6 ws1e9">oaspase</div><div class="t m3fb xce h3ff y3fd ff2 fs3fb fc0 sc0 ls2">9</div><div class="t m3fc x105 h400 y3fe ff2 fs3fc fc0 sc0 ls2d7 ws1ea">inicia</div><div class="t m3fd xe3 h401 y3ff ff2 fs3fd fc0 sc0 ls2">a</div><div class="t m3fe xfb h402 y400 ff2 fs3fe fc0 sc0 ls2d8">via</div><div class="t m3ff x3f h403 y401 ff1ee fs3ff fc0 sc0 ls2d9 ws1eb">intrínseca</div><div class="t m400 xf5 h404 y402 ff1ef fs400 fc0 sc0 ls2">)</div><div class="t m401 xb h405 y403 ffc fs401 fc0 sc0 ls2">\u21b3</div><div class="t m402 x85 h406 y404 ff1f0 fs402 fc0 sc0 ls2da ws1ec">Etapas</div><div class="t m403 x7f h407 y405 ff2 fs403 fc0 sc0 ls2">:</div><div class="t m404 x2d h408 y406 ff2 fs404 fc0 sc0 ls2">^</div><div class="t m405 x9c h409 y407 ff2 fs405 fc0 sc0 ls2">.</div><div class="t m406 xc h40a y408 ff1f1 fs406 fc0 sc0 ls2db">quando</div><div class="t m407 x64 h40b y409 ff2 fs407 fc0 sc0 ls2dc">as</div><div class="t m408 xd h40c y40a ff1f2 fs408 fc0 sc0 ls2dd ws1ed">àlulas</div><div class="t m409 x77 h40d y40b ff1f3 fs409 fc0 sc0 ls2de">são</div><div class="t m40a x9e h40e y40c ff1f4 fs40a fc0 sc0 ls2df ws1ee">privadas</div><div class="t m40b x67 h40f y40d ff1f5 fs40b fc0 sc0 ls2e0">de</div><div class="t m40c x8a h410 y40e ff1f6 fs40c fc0 sc0 ls2e1 ws1ef">fa<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m40d x29 h411 y40f ff2 fs40d fc0 sc0 ls2e2">de</div><div class="t m40e xbe h412 y410 ff1f7 fs40e fc0 sc0 ls2e3 ws1f0">crescimento</div><div class="t m40f x36 h413 y411 ff2 fs40f fc0 sc0 ls2">e</div><div class="t m410 xbf h414 y412 ff1f8 fs410 fc0 sc0 ls2e4 ws1f1">outros</div><div class="t m411 x2d h415 y413 ff1f9 fs411 fc0 sc0 ls2e5">sinais</div><div class="t m412 x6a h416 y414 ff2 fs412 fc0 sc0 ls2e6">de</div><div class="t m413 x58 h417 y415 ff1fa fs413 fc0 sc0 ls2e7 ws1f2">sobre<span class="blank _4"></span>vivência</div><div class="t m414 x4c h418 y416 ff2 fs414 fc0 sc0 ls2e8">ou</div><div class="t m415 xc3 h419 y417 ff2 fs415 fc0 sc0 ls2e9 ws1f3">são</div><div class="t m416 x3 h41a y418 ff1fb fs416 fc0 sc0 ls2ea ws1f4">wcp<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _3"> </span>to<span class="blank"> </span>e<span class="blank"> </span>o</div><div class="t m417 xb9 h41b y419 ff2 fs417 fc0 sc0 ls2">a</div><div class="t m418 x71 h41c y41a ff1fc fs418 fc0 sc0 ls2eb ws1f5">agentes</div><div class="t m419 xe0 h41d y41b ff1fd fs419 fc0 sc0 ls2ec ws1f6">que</div><div class="t m41a xc9 h41e y41c ff1fe fs41a fc0 sc0 ls2ed ws1f7">leram</div><div class="t m41b x38 h41f y41d ff2 fs41b fc0 sc0 ls2">o</div><div class="t m41c x8f h420 y41e ff2 fs41c fc0 sc0 ls2ee ws1f8">DNA</div><div class="t m41d x2d h421 y41f ff2 fs41d fc0 sc0 ls2ef">ou</div><div class="t m41e x4f h422 y420 ff1ff fs41e fc0 sc0 ls2f0 ws1f9">acumulam</div><div class="t m41f x8c h423 y421 ff200 fs41f fc0 sc0 ls2f1 ws1fa">quantidades</div><div class="t m420 xcf h424 y422 ff201 fs420 fc0 sc0 ls2f2 ws1fb">inaceitáv<span class="blank _4"></span>eis</div><div class="t m421 x32 h425 y423 ff202 fs421 fc0 sc0 ls2f3">de</div><div class="t m422 x3e h426 y424 ff203 fs422 fc0 sc0 ls2f4 ws1fc">pr<span class="blank _4"></span>o<span class="blank _2"> </span>teínas</div><div class="t m423 x8 h427 y425 ff204 fs423 fc0 sc0 ls2f5 ws1fd">anormalmente</div><div class="t m424 xb h428 y426 ff205 fs424 fc0 sc0 ls2f6 ws1fe">dobradas</div><div class="t m425 x63 h429 y427 ff2 fs425 fc0 sc0 ls2">,</div><div class="t m426 x87 h42a y428 ff2 fs426 fc0 sc0 ls2f7">um</div><div class="t m427 xe9 h42b y429 ff206 fs427 fc0 sc0 ls2f8 ws1ff">grupo</div><div class="t m428 x4b h42c y42a ff207 fs428 fc0 sc0 ls2f9">de</div><div class="t m429 xcf h42d y42b ff208 fs429 fc0 sc0 ls2fa ws200">pr<span class="blank _4"></span>oteínas</div><div class="t m42a xa3 h42e y42c ff2 fs42a fc0 sc0 ls2fb ws201">sensoras</div><div class="t m42b xe3 h42f y42d ff2 fs42b fc0 sc0 ls2">é</div><div class="t m42c x106 h430 y42e ff209 fs42c fc0 sc0 ls2fc ws202">ativado</div><div class="t m42d xd6 h431 y42f ff2 fs42d fc0 sc0 ls2">,</div><div class="t m42e xf1 h432 y430 ff2 fs42e fc0 sc0 ls2fd">as</div><div class="t m42f x73 h433 y431 ff2 fs42f fc0 sc0 ls2fe">BH</div><div class="t m430 xf5 h434 y432 ff2 fs430 fc0 sc0 ls2">3</div><div class="t m431 x1b h435 y433 ff2 fs431 fc0 sc0 ls2ff">2.</div><div class="t m432 x79 h436 y434 ff20a fs432 fc0 sc0 ls300">As</div><div class="t m433 xab h437 y435 ff20b fs433 fc0 sc0 ls301">BH</div><div class="t m434 x86 h438 y436 ff2 fs434 fc0 sc0 ls2">3</div><div class="t m435 x63 h439 y437 ff2 fs435 fc0 sc0 ls2">,</div><div class="t m436 xb0 h43a y438 ff2 fs436 fc0 sc0 ls302 ws203">por</div><div class="t m437 x1d h43b y439 ff2 fs437 fc0 sc0 ls303">sua</div><div class="t m438 xe h43c y43a ff2 fs438 fc0 sc0 ls304 ws204">vez</div><div class="t m439 xd9 h43d y43b ff2 fs439 fc0 sc0 ls2">,</div><div class="t m43a xe2 h43e y43c ff20c fs43a fc0 sc0 ls305">atiram</div><div class="t m43b x89 h43f y43d ff20d fs43b fc0 sc0 ls306">duas</div><div class="t m43c x6f h440 y43e ff20e fs43c fc0 sc0 ls307 ws205">moléculas</div><div class="t m43d xd7 h441 y43f ff20f fs43d fc0 sc0 ls308 ws206">praapoptót<span class="blank _4"></span>eias</div><div class="t m43e xa h442 y440 ff2 fs43e fc0 sc0 ls2">,</div><div class="t m43f x107 h443 y441 ff2 fs43f fc0 sc0 ls309">as</div><div class="t m440 x38 h444 y442 ff210 fs440 fc0 sc0 ls30a">Bao</div><div class="t m441 x90 h445 y443 ff2 fs441 fc0 sc0 ls2">e</div><div class="t m442 x2d h446 y444 ff211 fs442 fc0 sc0 ls30b">Bak</div><div class="t m443 xf3 h447 y445 ff2 fs443 fc0 sc0 ls2">,</div><div class="t m444 x100 h448 y446 ff2 fs444 fc0 sc0 ls30c">que</div><div class="t m445 x64 h449 y447 ff2 fs445 fc0 sc0 ls30d">se</div><div class="t m446 x5a h44a y448 ff212 fs446 fc0 sc0 ls30e ws207">dimerizam</div><div class="t m447 x97 h44b y449 ff2 fs447 fc0 sc0 ls2">e</div><div class="t m448 xfe h44c y44a ff2 fs448 fc0 sc0 ls30f">se</div><div class="t m449 xee h44d y44b ff213 fs449 fc0 sc0 ls310 ws208">inserem</div><div class="t m44a x32 h44e y44c ff214 fs44a fc0 sc0 ls311 ws209">dentro</div><div class="t m44b xd7 h44f y44d ff2 fs44b fc0 sc0 ls312">da</div><div class="t m44c x60 h450 y44e ff215 fs44c fc0 sc0 ls313 ws20a">membrana</div><div class="t m44d x1b h451 y44f ff1 fs44d fc0 sc0 ls2a3 ws20b">mit<span class="blank _4"></span>ocondrial</div><div class="t m44e x2e h452 y450 ff2 fs44e fc0 sc0 ls2">,</div><div class="t m44f xbc h453 y451 ff216 fs44f fc0 sc0 ls314 ws20c">alterando</div><div class="t m450 x13 h454 y452 ff2 fs450 fc0 sc0 ls2">a</div><div class="t m451 xcc h455 y453 ff217 fs451 fc0 sc0 ls315 ws20d">permeabilidade</div><div class="t m452 x108 h456 y454 ff218 fs452 fc0 sc0 ls316 ws20e">mitocondrial</div><div class="t m453 xe3 h457 y455 ff2 fs453 fc0 sc0 ls2">e</div><div class="t m454 xfb h458 y456 ff219 fs454 fc0 sc0 ls317 ws20f">fo<span class="blank"> </span>r<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank"> </span>d<span class="blank"> </span>o</div><div class="t m455 xd1 h459 y457 ff2 fs455 fc0 sc0 ls318 ws210">canais</div><div class="t m456 x75 h45a y458 ff2 fs456 fc0 sc0 ls319 ws211">por</div><div class="t m457 x1b h45b y459 ff2 fs457 fc0 sc0 ls31a ws212">onde</div><div class="t m458 xab h45c y45a ff2 fs458 fc0 sc0 ls2">o</div><div class="t m459 x23 h45d y45b ff21a fs459 fc0 sc0 ls31b ws213">citocromo</div><div class="t m45a x92 h45e y45c ff2 fs45a fc0 sc0 ls2">C</div><div class="t m45b x2f h45f y45d ff2 fs45b fc0 sc0 ls2">e</div><div class="t m45c xcb h460 y45e ff21b fs45c fc0 sc0 ls31c ws214">outras</div><div class="t m45d xb5 h461 y45f ff21c fs45d fc0 sc0 ls31d ws215">prot<span class="blank _4"></span>eínas</div><div class="t m45e x10 h462 y460 ff21d fs45e fc0 sc0 ls31e ws216">mitocondriais</div><div class="t m45f x71 h463 y461 ff21e fs45f fc0 sc0 ls31f ws217">ext<span class="blank"> </span>r<span class="blank"> </span>ava<span class="blank"> </span>s<span class="blank"> </span>a<span class="blank"> </span>m</div><div class="t m460 x47 h464 y462 ff21f fs460 fc0 sc0 ls320 ws218">para</div><div class="t m461 x109 h465 y463 ff2 fs461 fc0 sc0 ls2">o</div><div class="t m462 x8f h466 y464 ff220 fs462 fc0 sc0 ls321 ws219">idoso</div><div class="t m463 xe7 h467 y465 ff2 fs463 fc0 sc0 ls2">.</div><div class="t m464 xaf h468 y466 ff221 fs464 fc0 sc0 ls322">Além</div><div class="t m465 xbc h469 y467 ff222 fs465 fc0 sc0 ls323 ws21a">disso</div><div class="t m466 x6b h46a y468 ff2 fs466 fc0 sc0 ls2">,</div><div class="t m467 x58 h46b y469 ff2 fs467 fc0 sc0 ls2a4 ws21b">essas</div><div class="t m468 x1 h46c y46a ff223 fs468 fc0 sc0 ls324 ws21c">pr<span class="blank _0"></span>oteínas</div><div class="t m469 xfe h46d y46b ff2 fs469 fc0 sc0 ls325 ws21d">sensoras</div><div class="t m46a x5d h46e y46c ff224 fs46a fc0 sc0 ls326">inibem</div><div class="t m46b xcd h46f y46d ff2 fs46b fc0 sc0 ls327">as</div><div class="t m46c xfd h470 y46e ff225 fs46c fc0 sc0 ls328 ws21e">moléculas</div><div class="t m46d x7 h471 y46f ff226 fs46d fc0 sc0 ls329 ws21f">antiapoptó</div><div class="t m46e xf6 h472 y470 ff2 fs46e fc0 sc0 ls2">-</div><div class="t m46f x0 h473 y471 ff227 fs46f fc0 sc0 ls32a ws220">tiras</div><div class="t m470 x62 h474 y472 ff2 fs470 fc0 sc0 ls2">B</div><div class="t m471 x6a h475 y473 ff228 fs471 fc0 sc0 ls32b">d2</div><div class="t m472 x58 h476 y474 ff2 fs472 fc0 sc0 ls2">e</div><div class="t m473 x4a h477 y475 ff229 fs473 fc0 sc0 ls32c">Bd</div><div class="t m474 x5b h478 y476 ff2 fs474 fc0 sc0 ls2">-</div><div class="t m475 x2f h479 y477 ff2 fs475 fc0 sc0 ls32d">xl</div><div class="t m476 xc0 h47a y478 ff2 fs476 fc0 sc0 ls2">,</div><div class="t m477 x4b h47b y479 ff2 fs477 fc0 sc0 ls2">o</div><div class="t m195 x26 h47c y47a ff22a fs478 fc0 sc0 ls32e">que</div><div class="t m478 x44 h47d y47b ff22b fs479 fc0 sc0 ls32f ws221">aumenta</div><div class="t m479 xea h47e y47c ff2 fs47a fc0 sc0 ls2">o</div><div class="t m47a x82 h47f y47d ff22c fs47b fc0 sc0 ls330 ws222">ext<span class="blank"> </span>r<span class="blank"> </span>ava<span class="blank"> </span>s<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>e<span class="blank"> </span>n<span class="blank"> </span>t<span class="blank"> </span>o</div><div class="t m47b x73 h480 y47e ff22d fs47c fc0 sc0 ls331 ws223">dessas</div><div class="t m47c x2d h481 y47f ff1 fs47d fc0 sc0 ls2a5 ws224">pr<span class="blank _1"></span>oteínas</div><div class="t m47d xbb h482 y480 ff22e fs47e fc0 sc0 ls332 ws225">mitocondriais</div><div class="t m47e x2d h483 y481 ff2 fs47f fc0 sc0 ls333">3.</div><div class="t m47f x4f h484 y482 ff22f fs480 fc0 sc0 ls334">Em</div><div class="t m480 x39 h485 y483 ff230 fs481 fc0 sc0 ls335 ws226">conjunto</div><div class="t m481 x5a h486 y484 ff2 fs482 fc0 sc0 ls336">com</div><div class="t m482 x83 h487 y485 ff231 fs483 fc0 sc0 ls337">alguns</div><div class="t m483 x43 h488 y486 ff232 fs484 fc0 sc0 ls338 ws227">cof<span class="blank _0"></span>atous</div><div class="t m484 xa3 h489 y487 ff2 fs485 fc0 sc0 ls2">,</div><div class="t m485 x5d h48a y488 ff2 fs486 fc0 sc0 ls2">o</div><div class="t m486 x10a h48b y489 ff233 fs487 fc0 sc0 ls339 ws228">citocromo</div><div class="t m487 x5e h48c y48a ff2 fs488 fc0 sc0 ls2">C</div><div class="t m488 x34 h48d y48b ff234 fs489 fc0 sc0 ls33a ws229">ativa</div><div class="t m489 xa0 h48e y48c ff2 fs48a fc0 sc0 ls2">e</div><div class="t m48a x47 h48f y48d ff235 fs48b fc0 sc0 ls33b ws22a">caspase</div><div class="t m48b xa1 h490 y48e ff236 fs48c fc0 sc0 ls2">9</div><div class="t m48c x10b h491 y48f ff2 fs48d fc0 sc0 ls2">.</div><div class="t m48d xe8 h492 y490 ff237 fs48e fc0 sc0 ls33c ws22b">Outras</div><div class="t m48e xbd h493 y491 ff238 fs48f fc0 sc0 ls33d ws22c">prot<span class="blank _4"></span>eínas</div><div class="t m48f x2f h494 y492 ff2 fs490 fc0 sc0 ls33e">que</div><div class="t m490 x15 h495 y493 ff2 fs491 fc0 sc0 ls33f ws22d">atrasaram</div><div class="t m491 xef h496 y494 ff239 fs492 fc0 sc0 ls340 ws22e">das</div><div class="t m492 x82 h497 y495 ff23a fs493 fc0 sc0 ls341 ws22f">mitocôndrias</div><div class="t m493 x5 h498 y496 ff23b fs494 fc0 sc0 ls342 ws230">bloqueiam</div><div class="t m494 x69 h499 y497 ff2 fs495 fc0 sc0 ls343">as</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf7" class="pf w0 hc" data-page-no="7"><div class="pc pc7 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg7.png"><div class="t m495 x6 h49a y498 ff23c fs496 fc1 sc0 ls344 ws4">Células expostas a </div><div class="t m495 x9a h49a y499 ff23c fs496 fc1 sc0 ls2 ws4">fatores de crescimento </div><div class="t m495 x55 h49a y49a ff23c fs496 fc1 sc0 ls344 ws4">e outros sinais de </div><div class="t m495 xf8 h49a y49b ff23c fs496 fc1 sc0 ls2 ws4">sobrevivência: +Bcl-2, </div><div class="t m495 xc9 h49a y49c ff23c fs496 fc1 sc0 ls2 ws4">+Bcl-xL, -Bax, -Bak.</div><div class="t m495 x6 h49a y49d ff23c fs496 fc1 sc0 ls344 ws4">Células privadas de </div><div class="t m495 x10c h49a y49e ff23c fs496 fc1 sc0 ls2 ws4">fatores de </div><div class="t m495 x6 h49a y49f ff23c fs496 fc1 sc0 ls2 ws4">crescimento: +Bax, </div><div class="t m495 x104 h49a y4a0 ff23c fs496 fc1 sc0 ls2 ws4">+Bak, -Bcl-2, -Bcl-xL. </div><div class="t m496 xaf h49b y4a1 ff23d fs497 fc0 sc0 ls358 ws231">atividades</div><div class="t m497 x64 h49c y4a2 ff23e fs498 fc0 sc0 ls359">dos</div><div class="t m498 x13 h49d y4a3 ff23f fs499 fc0 sc0 ls35a ws232">antagonistas</div><div class="t m499 xb1 h49e y4a4 ff240 fs49a fc0 sc0 ls35b ws233">das</div><div class="t m49a x3 h49f y4a5 ff241 fs49b fc0 sc0 ls35c ws234">aapases</div><div class="t m49b x10d h4a0 y4a6 ff2 fs49c fc0 sc0 ls2">,</div><div class="t m49c xc6 h4a1 y4a7 ff2 fs49d fc0 sc0 ls35d">os</div><div class="t m49d xcd h4a2 y4a8 ff242 fs49e fc0 sc0 ls35e ws235">quais</div><div class="t m49e xf0 h4a3 y4a9 ff243 fs49f fc0 sc0 ls345 ws236">funcionam</div><div class="t m49f x69 h4a4 y4aa ff2 fs4a0 fc0 sc0 ls346 ws237">como</div><div class="t m4a0 xb h4a5 y4ab ff244 fs4a1 fc0 sc0 ls35f ws238">inibidores</div><div class="t m4a1 x6b h4a6 y4ac ff245 fs4a2 fc0 sc0 ls360 ws239">fisiológicos</div><div class="t m4a2 xa6 h4a7 y4ad ff2 fs4a3 fc0 sc0 ls361">da</div><div class="t m4a3 x5c h4a8 y4ae ff246 fs4a4 fc0 sc0 ls362 ws23a">apoptose</div><div class="t m4a4 xff h4a9 y4af ff2 fs4a5 fc0 sc0 ls2">.</div><div class="t m4a5 x10e h4aa y4b0 ff247 fs4a6 fc0 sc0 ls363">Então</div><div class="t m4a6 xdf h4ab y4b1 ff2 fs4a7 fc0 sc0 ls2">,</div><div class="t m4a7 xa9 h4ac y4b2 ff2 fs4a8 fc0 sc0 ls2">o</div><div class="t m4a8 x3e h4ad y4b3 ff248 fs4a9 fc0 sc0 ls364 ws23b">res<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>o</div><div class="t m4a9 x20 h4ae y4b4 ff249 fs4aa fc0 sc0 ls347 ws23c">final</div><div class="t m4aa x10f h4af y4b5 ff2 fs4ab fc0 sc0 ls2">é</div><div class="t m4ab xfc h4b0 y4b6 ff2 fs4ac fc0 sc0 ls2">a</div><div class="t m4ac x1b h4b1 y4b7 ff1 fs4ad fc0 sc0 ls348 ws23d">ativ<span class="blank _0"></span>ação</div><div class="t m4ad xf3 h4b2 y4b8 ff24a fs4ae fc0 sc0 ls365">da</div><div class="t m4ae x94 h4b3 y4b9 ff24b fs4af fc0 sc0 ls366 ws23e">cascata</div><div class="t m4af xe h4b4 y4ba ff24c fs4b0 fc0 sc0 ls367">de</div><div class="t m4b0 x9d h4b5 y4bb ff24d fs4b1 fc0 sc0 ls368 ws23f">caspases</div><div class="t m4b1 xf2 h4b6 y4bc ff2 fs4b2 fc0 sc0 ls2">,</div><div class="t m4b2 x6e h4b7 y4bd ff2 fs4b3 fc0 sc0 ls369">que</div><div class="t m4b3 xce h4b8 y4be ff2 fs4b4 fc0 sc0 ls36a ws240">lev<span class="blank _0"></span>a</div><div class="t m4b4 x17 h4b9 y4bf ff2 fs4b5 fc0 sc0 ls2">à</div><div class="t m4b5 xb9 h4ba y4c0 ff24e fs4b6 fc0 sc0 ls349 ws241">fragmentação</div><div class="t m4b6 xa h4bb y4c1 ff24f fs4b7 fc0 sc0 ls36b ws242">nuclear</div><div class="t m4b7 x2c h4bc y4c2 ff2 fs4b8 fc0 sc0 ls2">.</div><div class="t m4b8 xeb h4bd y4c3 ff2 fs4b9 fc0 sc0 ls2">O</div><div class="t m4b9 xb h4be y4c4 ff2 fs4ba fc0 sc0 ls2">*</div><div class="t m4ba xc h4bf y4c5 ff2 fs4bb fc0 sc0 ls36c">em</div><div class="t m4bb xab h4c0 y4c6 ff250 fs4bc fc0 sc0 ls36d ws243">situações</div><div class="t m4bc xd h4c1 y4c7 ff251 fs4bd fc0 sc0 ls36e ws244">normais</div><div class="t m4bd x103 h4c2 y4c8 ff2 fs4be fc0 sc0 ls2">a</div><div class="t m4be x27 h4c3 y4c9 ff252 fs4bf fc0 sc0 ls36f ws245">pr<span class="blank _4"></span>oteína</div><div class="t m4bf xce h4c4 y4ca ff2 fs4c0 fc0 sc0 ls370 ws246">nuclear</div><div class="t m4c0 x110 h4c5 y4cb ff2 fs4c1 fc0 sc0 ls371">PS3</div><div class="t m4c1 x11 h4c6 y4cc ff2 fs4c2 fc0 sc0 ls2">(</div><div class="t m4c2 x5f h4c7 y4cd ff253 fs4c3 fc0 sc0 ls372 ws247">chamada</div><div class="t m4c3 xb h4c8 y4ce ff254 fs4c4 fc0 sc0 ls373">de</div><div class="t m4c4 x4f h4c9 y4cf ff255 fs4c5 fc0 sc0 ls34a ws248">guar<span class="blank _4"></span>diã</div><div class="t m4c5 xc2 h4ca y4d0 ff256 fs4c6 fc0 sc0 ls374">do</div><div class="t m4c6 xb7 h4cb y4d1 ff257 fs4c7 fc0 sc0 ls375 ws249">genoma</div><div class="t m4c7 xd9 h4cc y4d2 ff2 fs4c8 fc0 sc0 ls2">)</div><div class="t m4c8 xf h4cd y4d3 ff2 fs4c9 fc0 sc0 ls376 ws24a">ativa</div><div class="t m4c9 xb1 h4ce y4d4 ff2 fs4ca fc0 sc0 ls377 ws24b">carapaus</div><div class="t m4ca x105 h4cf y4d5 ff258 fs4cb fc0 sc0 ls378 ws24c">atrav<span class="blank _4"></span>és</div><div class="t m4cb x111 h4d0 y4d6 ff259 fs4cc fc0 sc0 ls379">da</div><div class="t m4cc xc8 h4d1 y4d7 ff25a fs4cd fc0 sc0 ls37a ws24d">ativação</div><div class="t m4cd x2d h4d2 y4d8 ff25b fs4ce fc0 sc0 ls37b">das</div><div class="t m4ce x61 h4d3 y4d9 ff25c fs4cf fc0 sc0 ls37c ws24e">pr<span class="blank _0"></span>oteínas</div><div class="t m4cf xe9 h4d4 y4da ff2 fs4d0 fc0 sc0 ls37d ws24f">sensoras</div><div class="t m4d0 x26 h4d5 y4db ff2 fs4d1 fc0 sc0 ls2">e</div><div class="t m4d1 x7b h4d6 y4dc ff25d fs4d2 fc0 sc0 ls37e ws250">consequente</div><div class="t m4d2 xd0 h4d7 y4dd ff25e fs4d3 fc0 sc0 ls37f ws251">bloqueio</div><div class="t m4d3 xfd h4d8 y4de ff25f fs4d4 fc0 sc0 ls380">das</div><div class="t m4d4 x1b h4d9 y4df ff1 fs4d5 fc0 sc0 ls34b ws252">pr<span class="blank _4"></span>ot<span class="blank _4"></span>eínas</div><div class="t m4d5 x39 h4da y4e0 ff260 fs4d6 fc0 sc0 ls381 ws253">aãliapoptótvias</div><div class="t m4d6 xcb h4db y4e1 ff2 fs4d7 fc0 sc0 ls2">.</div><div class="t m4d7 x112 h4dc y4e2 ff2 fs4d8 fc0 sc0 ls382">Uma</div><div class="t m4d8 x27 h4dd y4e3 ff261 fs4d9 fc0 sc0 ls383 ws254">mutação</div><div class="t m4d9 x101 h4de y4e4 ff2 fs4da fc0 sc0 ls384">no</div><div class="t m4da x45 h4df y4e5 ff2 fs4db fc0 sc0 ls385">gene</div><div class="t m4db xf4 h4e0 y4e6 ff2 fs4dc fc0 sc0 ls386">PS3</div><div class="t m4dc x5f h4e1 y4e7 ff2 fs4dd fc0 sc0 ls34c ws255">causa</div><div class="t m4dd x1b h4e2 y4e8 ff262 fs4de fc0 sc0 ls387">inibição</div><div class="t m4de x24 h4e3 y4e9 ff263 fs4df fc0 sc0 ls388">da</div><div class="t m4df x41 h4e4 y4ea ff264 fs4e0 fc0 sc0 ls389 ws256">apoptose</div><div class="t m4e0 x9d h4e5 y4eb ff2 fs4e1 fc0 sc0 ls38a">em</div><div class="t m4e1 xcf h4e6 y4ec ff265 fs4e2 fc0 sc0 ls38b ws257">tumores</div><div class="t m4e2 xa8 h4e7 y4ed ff266 fs4e3 fc0 sc0 ls34d ws258">malignos</div><div class="t m4e3 xf4 h4e8 y4ee ff2 fs4e4 fc0 sc0 ls2">,</div><div class="t m4e4 x68 h4e9 y4ef ff2 fs4e5 fc0 sc0 ls2">o</div><div class="t m4e5 xfb h4ea y4f0 ff2 fs4e6 fc0 sc0 ls38c">que</div><div class="t m4e6 xbe h4eb y4f1 ff2 fs4e7 fc0 sc0 ls38d ws259">lev<span class="blank _0"></span>a</div><div class="t m4e7 xb h4ec y4f2 ff2 fs4e8 fc0 sc0 ls38e">ao</div><div class="t m4e8 xf3 h4ed y4f3 ff2 fs4e9 fc0 sc0 ls38f ws25a">câncer</div><div class="t m4e9 xd4 h4ee y4f4 ff2 fs4ea fc0 sc0 ls2">(</div><div class="t m4ea xb4 h4ef y4f5 ff267 fs4eb fc0 sc0 ls390 ws25b">present<span class="blank _0"></span>e</div><div class="t m4eb x1 h4f0 y4f6 ff2 fs4ec fc0 sc0 ls391">em</div><div class="t m4ec xe2 h4f1 y4f7 ff2 fs4ed fc0 sc0 ls392">só</div><div class="t m4ed x1e h4f2 y4f8 ff2 fs4ee fc0 sc0 ls2">-</div><div class="t m4ee xb5 h4f3 y4f9 ff2 fs4ef fc0 sc0 ls393 ws25c">dos</div><div class="t m4ef x6e h4f4 y4fa ff268 fs4f0 fc0 sc0 ls394 ws25d">cânceres</div><div class="t m4f0 xea h4f5 y4fb ff269 fs4f1 fc0 sc0 ls2">)</div><div class="t m4f1 xdf h4f6 y4fc ff2 fs4f2 fc0 sc0 ls2">,</div><div class="t m4f2 xa9 h4f7 y4fd ff2 fs4f3 fc0 sc0 ls34e ws25e">essas</div><div class="t m4f3 x8e h4f8 y4fe ff26a fs4f4 fc0 sc0 ls395 ws25f">mutações</div><div class="t m4f4 x9a h4f9 y4ff ff26b fs4f5 fc0 sc0 ls396 ws260">podem</div><div class="t m4f5 xfc h4fa y500 ff2 fs4f6 fc0 sc0 ls397">ser</div><div class="t m4f6 x1b h4fb y501 ff1 fs4f7 fc0 sc0 ls398">genéticas</div><div class="t m4f7 x7c h4fc y502 ff2 fs4f8 fc0 sc0 ls399">mas</div><div class="t m4f8 xb4 h4fd y503 ff26c fs4f9 fc0 sc0 ls39a ws261">também</div><div class="t m4f9 xd9 h4fe y504 ff26d fs4fa fc0 sc0 ls39b ws262">podem</div><div class="t m4fa xfe h4ff y505 ff2 fs4fb fc0 sc0 ls39c">ser</div><div class="t m4fb x3b h500 y506 ff26e fs4fc fc0 sc0 ls39d ws263">causadas</div><div class="t m4fc x33 h501 y507 ff2 fs4fd fc0 sc0 ls39e ws264">por</div><div class="t m4fd x71 h502 y508 ff26f fs4fe fc0 sc0 ls34f ws265">cigarr<span class="blank _4"></span>o</div><div class="t m4fe x21 h503 y509 ff2 fs4ff fc0 sc0 ls2">,</div><div class="t m4ff xeb h504 y50a ff270 fs500 fc0 sc0 ls39f ws266">álcool</div><div class="t m500 xf5 h505 y50b ff2 fs501 fc0 sc0 ls2">,</div><div class="t m501 x2b h506 y50c ff2 fs502 fc0 sc0 ls3a0 ws267">etc</div><div class="t m502 x75 h507 y50d ff2 fs503 fc0 sc0 ls2">.</div><div class="t m503 x6b h508 y50e ff271 fs504 fc0 sc0 ls3a1 ws268">dano</div><div class="t m504 xbb h509 y50f ff2 fs505 fc0 sc0 ls3a2">do</div><div class="t m505 x6b h50a y510 ff2 fs506 fc0 sc0 ls3a3 ws269">DNA</div><div class="t m506 xb h50b y511 ff272 fs507 fc0 sc0 ls3a4">b.</div><div class="t m507 x4f h50c y512 ff2 fs508 fc0 sc0 ls3a5">via</div><div class="t m508 x113 h50d y513 ff273 fs509 fc0 sc0 ls3a6 ws26a">ext<span class="blank"> </span>r<span class="blank"> </span>í<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>a</div><div class="t m509 xe h50e y514 ff2 fs50a fc0 sc0 ls2">:</div><div class="t m50a xe8 h50f y515 ffc fs50b fc0 sc0 ls2">\u21b3</div><div class="t m50b x85 h510 y516 ff274 fs50c fc0 sc0 ls3a7 ws26b">muitas</div><div class="t m50c x63 h511 y517 ff275 fs50d fc0 sc0 ls3a8">células</div><div class="t m50d xad h512 y518 ff2 fs50e fc0 sc0 ls3a9 ws26c">apressam</div><div class="t m50e x9e h513 y519 ff276 fs50f fc0 sc0 ls3aa ws26d">moléculas</div><div class="t m50f x45 h514 y51a ff277 fs510 fc0 sc0 ls3ab">de</div><div class="t m510 xc6 h515 y51b ff278 fs511 fc0 sc0 ls3ac ws26e">super<span class="blank"> </span>fície</div><div class="t m511 x54 h516 y51c ff2 fs512 fc0 sc0 ls2">,</div><div class="t m512 x114 h517 y51d ff279 fs513 fc0 sc0 ls3ad">chamados</div><div class="t m513 x56 h518 y51e ff27a fs514 fc0 sc0 ls3ae ws26f">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m514 x2d h519 y51f ff2 fs515 fc0 sc0 ls3af">de</div><div class="t m515 x85 h51a y520 ff27b fs516 fc0 sc0 ls3b0 ws270">mor<span class="blank"> </span>te</div><div class="t m516 x23 h51b y521 ff2 fs517 fc0 sc0 ls2">,</div><div class="t m517 x7d h51c y522 ff2 fs518 fc0 sc0 ls3b1">que</div><div class="t m518 x50 h51d y523 ff27c fs519 fc0 sc0 ls2 ws271">disparam</div><div class="t m519 xcf h51e y524 ff2 fs51a fc0 sc0 ls2">a</div><div class="t m51a xb5 h51f y525 ff2 fs51b fc0 sc0 ls3b2 ws272">apoptose</div><div class="t m51b x84 h520 y526 ff2 fs51c fc0 sc0 ls2">.</div><div class="t m51c x3 h521 y527 ff2 fs51d fc0 sc0 ls2">A</div><div class="t m51d xef h522 y528 ff2 fs51e fc0 sc0 ls3b3">maioria</div><div class="t m51e xa5 h523 y529 ff27d fs51f fc0 sc0 ls3b4 ws273">dessas</div><div class="t m51f x19 h524 y52a ff27e fs520 fc0 sc0 ls3b5 ws274">moléculas</div><div class="t m520 x115 h525 y52b ff2 fs521 fc0 sc0 ls3b6 ws275">são</div><div class="t m521 x0 h526 y52c ff27f fs522 fc0 sc0 ls3b7 ws276">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m522 x63 h527 y52d ff280 fs523 fc0 sc0 ls3b8 ws277">membros</div><div class="t m523 x6d h528 y52e ff2 fs524 fc0 sc0 ls3b9">da</div><div class="t m524 x88 h529 y52f ff281 fs525 fc0 sc0 ls350 ws278">f<span class="blank _4"></span>amília</div><div class="t m525 xa7 h52a y530 ff282 fs526 fc0 sc0 ls3ba">do</div><div class="t m526 x10e h52b y531 ff283 fs527 fc0 sc0 ls3bb ws279">fa<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank _2"> </span>r</div><div class="t m527 x17 h52c y532 ff284 fs528 fc0 sc0 ls3bc">de</div><div class="t m528 xf4 h52d y533 ff2 fs529 fc0 sc0 ls3bd ws27a">necrose</div><div class="t m529 x114 h52e y534 ff285 fs52a fc0 sc0 ls3be">tumoral</div><div class="t m52a x35 h52f y535 ff286 fs52b fc0 sc0 ls2">(</div><div class="t m52b x107 h530 y536 ff2 fs52c fc0 sc0 ls3bf">TNF</div><div class="t m52c x69 h531 y537 ff287 fs52d fc0 sc0 ls2">)</div><div class="t m52d xa1 h532 y538 ff2 fs52e fc0 sc0 ls2">,</div><div class="t m52e x116 h533 y539 ff2 fs52f fc0 sc0 ls3c0">que</div><div class="t m52f x1b h534 y53a ff288 fs530 fc0 sc0 ls3c1 ws27b">contém</div><div class="t m530 x7c h535 y53b ff2 fs531 fc0 sc0 ls3c2">em</div><div class="t m531 x7f h536 y53c ff2 fs532 fc0 sc0 ls351 ws27c">suas</div><div class="t m532 x8b h537 y53d ff289 fs533 fc0 sc0 ls3c3 ws27d">reg<span class="blank"> </span>i<span class="blank"> </span>õ<span class="blank"> </span>e<span class="blank"> </span>s</div><div class="t m533 x15 h538 y53e ff28a fs534 fc0 sc0 ls352 ws27e">citoplasmático</div><div class="t m534 x32 h539 y53f ff2 fs535 fc0 sc0 ls3c4">um</div><div class="t m535 xf4 h53a y540 ff2 fs536 fc0 sc0 ls2">"</div><div class="t m536 x68 h53b y541 ff28b fs537 fc0 sc0 ls3c5 ws27f">domínio</div><div class="t m537 x8 h53c y542 ff28c fs538 fc0 sc0 ls3c6">de</div><div class="t m538 xf8 h53d y543 ff2 fs539 fc0 sc0 ls3c7 ws280">mor<span class="blank"> </span>te</div><div class="t m539 x10f h53e y544 ff2 fs53a fc0 sc0 ls2">"</div><div class="t m53a xe4 h53f y545 ff2 fs53b fc0 sc0 ls2">,</div><div class="t m53b x69 h540 y546 ff2 fs53c fc0 sc0 ls3c8">que</div><div class="t m53c x0 h541 y547 ff2 fs53d fc0 sc0 ls3c9">medeia</div><div class="t m53d xbb h542 y548 ff2 fs53e fc0 sc0 ls2">a</div><div class="t m53e x24 h543 y549 ff28d fs53f fc0 sc0 ls3ca ws281">interação</div><div class="t m53f xe1 h544 y54a ff2 fs540 fc0 sc0 ls3cb">com</div><div class="t m540 x15 h545 y54b ff2 fs541 fc0 sc0 ls3cc ws282">outras</div><div class="t m541 x2 h546 y54c ff28e fs542 fc0 sc0 ls3cd ws283">pr<span class="blank _4"></span>oteínas</div><div class="t m542 x10d h547 y54d ff28f fs543 fc0 sc0 ls3ce ws284">env<span class="blank _4"></span>olvidas</div><div class="t m543 xde h548 y54e ff2 fs544 fc0 sc0 ls3cf">na</div><div class="t m544 xf1 h549 y54f ff290 fs545 fc0 sc0 ls3d0 ws285">mor<span class="blank"> </span>te</div><div class="t m545 x56 h54a y550 ff291 fs546 fc0 sc0 ls3d1 ws286">celular</div><div class="t m546 xd3 h54b y551 ff2 fs547 fc0 sc0 ls2">.</div><div class="t m547 xb h54c y552 ff292 fs548 fc0 sc0 ls3d2 ws287">Esses</div><div class="t m548 x62 h54d y553 ff293 fs549 fc0 sc0 ls3d3 ws288">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank _2"> </span>re<span class="blank"> </span>s</div><div class="t m549 xe9 h54e y554 ff2 fs54a fc0 sc0 ls3d4 ws289">ativam</div><div class="t m54a x88 h54f y555 ff294 fs54b fc0 sc0 ls3d5 ws28a">pr<span class="blank _4"></span>oteínas</div><div class="t m54b x1f h550 y556 ff295 fs54c fc0 sc0 ls3d6 ws28b">adaptadas</div><div class="t m54c xcd h551 y557 ff296 fs54d fc0 sc0 ls3d7 ws28c">citoplasmático</div><div class="t m54d x74 h552 y558 ff2 fs54e fc0 sc0 ls3d8">que</div><div class="t m54e x2d h553 y559 ff1 fs54f fc0 sc0 ls3d9 ws28d">re<span class="blank"> </span>c<span class="blank"> </span>r<span class="blank"> </span>u<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>m</div><div class="t m54f x2e h554 y55a ff2 fs550 fc0 sc0 ls2">a</div><div class="t m550 xbb h555 y55b ff297 fs551 fc0 sc0 ls3da ws28e">pró</div><div class="t m551 x6b h556 y55c ff2 fs552 fc0 sc0 ls2">-</div><div class="t m552 x58 h557 y55d ff2 fs553 fc0 sc0 ls3db ws28f">carpase</div><div class="t m553 x1 h558 y55e ff2 fs554 fc0 sc0 ls2">.</div><div class="t m554 x42 h559 y55f ff2 fs555 fc0 sc0 ls2">8</div><div class="t m555 x77 h55a y560 ff2 fs556 fc0 sc0 ls2">e</div><div class="t m556 x1e h55b y561 ff2 fs557 fc0 sc0 ls3dc ws290">ativam</div><div class="t m557 xff h55c y562 ff298 fs558 fc0 sc0 ls3dd ws291">outras</div><div class="t m558 x9f h55d y563 ff299 fs559 fc0 sc0 ls3de ws292">carapaus</div><div class="t m559 xfd h55e y564 ff2 fs55a fc0 sc0 ls2">,</div><div class="t m55a x2a h55f y565 ff29a fs55b fc0 sc0 ls3df ws293">res<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank"> </span>d<span class="blank"> </span>o</div><div class="t m55b x117 h560 y566 ff2 fs55c fc0 sc0 ls3e0">em</div><div class="t m55c x8f h561 y567 ff2 fs55d fc0 sc0 ls3e1 ws294">apoptose</div><div class="t m55d xb h562 y568 ffc fs55e fc0 sc0 ls2">\u21b3</div><div class="t m55e x85 h563 y569 ff2 fs55f fc0 sc0 ls3e2 ws295">essa</div><div class="t m55f x6a h564 y56a ff2 fs560 fc0 sc0 ls3e3">via</div><div class="t m560 x80 h565 y56b ff29b fs561 fc0 sc0 ls3e4 ws296">também</div><div class="t m561 xd9 h566 y56c ff29c fs562 fc0 sc0 ls3e5">pode</div><div class="t m562 x1e h567 y56d ff2 fs563 fc0 sc0 ls3e6">ser</div><div class="t m563 xb1 h568 y56e ff29d fs564 fc0 sc0 ls3e7">úmida</div><div class="t m564 xd0 h569 y56f ff2 fs565 fc0 sc0 ls3e8 ws297">por</div><div class="t m565 xc6 h56a y570 ff29e fs566 fc0 sc0 ls3e9 ws298">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m566 xde h56b y571 ff2 fs567 fc0 sc0 ls3ea">de</div><div class="t m567 x5 h56c y572 ff2 fs568 fc0 sc0 ls3eb ws299">mor<span class="blank"> </span>te</div><div class="t m568 x107 h56d y573 ff29f fs569 fc0 sc0 ls3ec ws29a">pro<span class="blank _0"></span>totípicos</div><div class="t m569 xe8 h56e y574 ff2 fs56a fc0 sc0 ls3ed">do</div><div class="t m56a x76 h56f y575 ff2a0 fs56b fc0 sc0 ls3ee">tipo</div><div class="t m56b x23 h570 y576 ff2 fs56c fc0 sc0 ls353 ws29b">TNFI</div><div class="t m56c x8c h571 y577 ff2 fs56d fc0 sc0 ls2">e</div><div class="t m56d x8b h572 y578 ff2 fs56e fc0 sc0 ls3ef ws29c">Fa<span class="blank"> </span>s</div><div class="t m56e xe1 h573 y579 ff2 fs56f fc0 sc0 ls2">.</div><div class="t m56f xcb h574 y57a ff2 fs570 fc0 sc0 ls2">O</div><div class="t m570 x77 h575 y57b ff2a1 fs571 fc0 sc0 ls354 ws29d">ligante</div><div class="t m571 xa7 h576 y57c ff2a2 fs572 fc0 sc0 ls3f0">de</div><div class="t m572 x3c h577 y57d ff2 fs573 fc0 sc0 ls3f1 ws29e">Fa<span class="blank"> </span>s</div><div class="t m573 xb6 h578 y57e ff2 fs574 fc0 sc0 ls2">(</div><div class="t m574 x32 h579 y57f ff2 fs575 fc0 sc0 ls3f2 ws29f">Fa<span class="blank"> </span>s</div><div class="t m575 xdd h57a y580 ff2 fs576 fc0 sc0 ls2">-</div><div class="t m576 xa4 h57b y581 ff2 fs577 fc0 sc0 ls2">L</div><div class="t m577 xcd h57c y582 ff2a3 fs578 fc0 sc0 ls2">)</div><div class="t m578 x111 h57d y583 ff2 fs579 fc0 sc0 ls2">é</div><div class="t m579 x72 h57e y584 ff2 fs57a fc0 sc0 ls3f3">uma</div><div class="t m57a x21 h57f y585 ff2a4 fs57b fc0 sc0 ls3f4 ws2a0">prot<span class="blank _4"></span>eína</div><div class="t m57b x2b h580 y586 ff2 fs57c fc0 sc0 ls3f5">de</div><div class="t m57c x2d h581 y587 ff1 fs57d fc0 sc0 ls355 ws2a1">membr<span class="blank _0"></span>ana</div><div class="t m57d x86 h582 y588 ff2 fs57e fc0 sc0 ls3f6 ws2a2">apressa</div><div class="t m57e x13 h583 y589 ff2 fs57f fc0 sc0 ls2">,</div><div class="t m57f x92 h584 y58a ff2a5 fs580 fc0 sc0 ls3f7 ws2a3">principalmente</div><div class="t m580 x78 h585 y58b ff2 fs581 fc0 sc0 ls2">,</div><div class="t m581 xa7 h586 y58c ff2 fs582 fc0 sc0 ls3f8">em</div><div class="t m582 x10 h587 y58d ff2a6 fs583 fc0 sc0 ls3f9 ws2a4">linf<span class="blank _4"></span>ócitos</div><div class="t m583 x3e h588 y58e ff2 fs584 fc0 sc0 ls2">T</div><div class="t m584 x71 h589 y58f ff2a7 fs585 fc0 sc0 ls3fa ws2a5">ativados</div><div class="t m585 x20 h58a y590 ff2 fs586 fc0 sc0 ls2">.</div><div class="t m586 xf1 h58b y591 ff2a8 fs587 fc0 sc0 ls3fb ws2a6">Cuando</div><div class="t m587 x69 h58c y592 ff2 fs588 fc0 sc0 ls356 ws2a7">essas</div><div class="t m588 xb h58d y593 ff2a9 fs589 fc0 sc0 ls3fc ws3b">células</div><div class="t m589 xbb h58e y594 ff2 fs58a fc0 sc0 ls2">T</div><div class="t m58a xbd h58f y595 ff2aa fs58b fc0 sc0 ls3fd ws2a8">rec<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>h<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>e<span class="blank"> </span>m</div><div class="t m58b xd9 h590 y596 ff2 fs58c fc0 sc0 ls3fe">os</div><div class="t m58c x51 h591 y597 ff2ab fs58d fc0 sc0 ls3ff ws2a9">alvos</div><div class="t m58d x78 h592 y598 ff2 fs58e fc0 sc0 ls400">que</div><div class="t m58e x84 h593 y599 ff2 fs58f fc0 sc0 ls401 ws2aa">exp<span class="blank"> </span>re<span class="blank"> </span>s<span class="blank"> </span>s<span class="blank"> </span>a<span class="blank"> </span>m</div><div class="t m58f x68 h594 y59a ff2 fs590 fc0 sc0 ls402 ws2ab">fas</div><div class="t m590 xfd h595 y59b ff2 fs591 fc0 sc0 ls2">,</div><div class="t m591 x60 h596 y59c ff2 fs592 fc0 sc0 ls403">as</div><div class="t m592 xd8 h597 y59d ff2ac fs593 fc0 sc0 ls404 ws2ac">moléculas</div><div class="t m593 xe4 h598 y59e ff2 fs594 fc0 sc0 ls405 ws2ad">fas</div><div class="t m594 x2c h599 y59f ff2ad fs595 fc0 sc0 ls406 ws2ae">são</div><div class="t m595 x2d h59a y5a0 ff2ae fs596 fc0 sc0 ls407 ws2af">ligadas</div><div class="t m596 x94 h59b y5a1 ff2 fs597 fc0 sc0 ls408">em</div><div class="t m597 x59 h59c y5a2 ff2af fs598 fc0 sc0 ls409 ws2b0">rea<span class="blank"> </span>ç<span class="blank"> </span>ã<span class="blank"> </span>o</div><div class="t m598 xd9 h59d y5a3 ff2b0 fs599 fc0 sc0 ls40a ws2b1">cruzada</div><div class="t m599 xb1 h59e y5a4 ff2b1 fs59a fc0 sc0 ls40b ws2b2">pelo</div><div class="t m59a x66 h59f y5a5 ff2 fs59b fc0 sc0 ls40c ws2b3">Fa<span class="blank"> </span>s</div><div class="t m59b x53 h5a0 y5a6 ff2 fs59c fc0 sc0 ls2">-</div><div class="t m59c xd0 h5a1 y5a7 ff2 fs59d fc0 sc0 ls2">L</div><div class="t m59d x9f h5a2 y5a8 ff2 fs59e fc0 sc0 ls2">e</div><div class="t m59e x110 h5a3 y5a9 ff2b2 fs59f fc0 sc0 ls40d ws2b4">prot<span class="blank _4"></span>eínas</div><div class="t m59f xe0 h5a4 y5aa ff2b3 fs5a0 fc0 sc0 ls40e">de</div><div class="t m5a0 xd1 h5a5 y5ab ff2b4 fs5a1 fc0 sc0 ls357 ws2b5">ligação</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf8" class="pf w0 hc" data-page-no="8"><div class="pc pc8 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg8.png"><div class="t m5a1 xaf h5a6 y5ac ff2b5 fs5a2 fc0 sc0 ls412 ws2b6">adaptadora</div><div class="t m5a2 xac h5a7 y5ad ff2b6 fs5a3 fc0 sc0 ls413 ws2b7">via</div><div class="t m5a3 xad h5a8 y5ae ff2b7 fs5a4 fc0 sc0 ls414 ws2b8">domínio</div><div class="t m5a4 x4c h5a9 y5af ff2b8 fs5a5 fc0 sc0 ls415">de</div><div class="t m5a5 xb1 h5aa y5b0 ff2b9 fs5a6 fc0 sc0 ls416 ws2b9">morte</div><div class="t m5a6 x10 h5ab y5b1 ff2 fs5a7 fc0 sc0 ls2">.</div><div class="t m5a7 x6f h5ac y5b2 ff2ba fs5a8 fc0 sc0 ls417 ws2ba">Estas</div><div class="t m5a8 xdd h5ad y5b3 ff2 fs5a9 fc0 sc0 ls418 ws2bb">são</div><div class="t m5a9 x4 h5ae y5b4 ff2 fs5aa fc0 sc0 ls419">as</div><div class="t m5aa x60 h5af y5b5 ff2bb fs5ab fc0 sc0 ls41a ws2bc">res<span class="blank"> </span>p<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>á<span class="blank"> </span>ve<span class="blank"> </span>i<span class="blank"> </span>s</div><div class="t m5ab x38 h5b0 y5b6 ff2 fs5ac fc0 sc0 ls41b ws2bd">por</div><div class="t m5ac x2d h5b1 y5b7 ff2bc fs5ad fc0 sc0 ls41c ws2be">rec<span class="blank"> </span>r<span class="blank"> </span>u<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>r</div><div class="t m5ad xca h5b2 y5b8 ff2 fs5ae fc0 sc0 ls2">e</div><div class="t m5ae x6b h5b3 y5b9 ff2bd fs5af fc0 sc0 ls41d ws2bf">ativar</div><div class="t m5af x65 h5b4 y5ba ff2 fs5b0 fc0 sc0 ls2">a</div><div class="t m5b0 x14 h5b5 y5bb ff2 fs5b1 fc0 sc0 ls41e ws2c0">carpase</div><div class="t m5b1 xb5 h5b6 y5bc ff2be fs5b2 fc0 sc0 ls2">8</div><div class="t m5b2 x44 h5b7 y5bd ff2 fs5b3 fc0 sc0 ls2">.</div><div class="t m5b3 xaf h5b8 y5be ffc fs5b4 fc0 sc0 ls2">\u21b3</div><div class="t m5b4 x57 h5b9 y5bf ff2bf fs5b5 fc0 sc0 ls41f ws2c1">Além</div><div class="t m5b5 xd4 h5ba y5c0 ff2c0 fs5b6 fc0 sc0 ls420 ws2c2">dessas</div><div class="t m5b6 x3a h5bb y5c1 ff2 fs5b7 fc0 sc0 ls2">,</div><div class="t m5b7 x2f h5bc y5c2 ff2c1 fs5b8 fc0 sc0 ls421 ws2c3">perf<span class="blank _0"></span>orinas</div><div class="t m5b8 x44 h5bd y5c3 ff2c2 fs5b9 fc0 sc0 ls422 ws2c4">liberadas</div><div class="t m5b9 x45 h5be y5c4 ff2c3 fs5ba fc0 sc0 ls423">pelo</div><div class="t m5ba x46 h5bf y5c5 ff2c4 fs5bb fc0 sc0 ls424 ws2c5">Ltc</div><div class="t m5bb x106 h5c0 y5c6 ff2c5 fs5bc fc0 sc0 ls425 ws2c6">também</div><div class="t m5bc x9a h5c1 y5c7 ff2c6 fs5bd fc0 sc0 ls426 ws2c7">ativam</div><div class="t m5bd x109 h5c2 y5c8 ff2 fs5be fc0 sc0 ls2">a</div><div class="t m5be x118 h5c3 y5c9 ff2c7 fs5bf fc0 sc0 ls427">via</div><div class="t m5bf xaf h5c4 y5ca ff2 fs5c0 fc0 sc0 ls428 ws2c8">dos</div><div class="t m5c0 x100 h5c5 y5cb ff2 fs5c1 fc0 sc0 ls429 ws2c9">carapaus</div><div class="t m5c1 x2d h5c6 y5cc ffc fs5c2 fc0 sc0 ls2">\u21b3</div><div class="t m5c2 x76 h5c7 y5cd ff2c8 fs5c3 fc0 sc0 ls42a ws2ca">Etapas</div><div class="t m5c3 xd4 h5c8 y5ce ff2 fs5c4 fc0 sc0 ls2">:</div><div class="t m5c4 xaf h5c9 y5cf ff2 fs5c5 fc0 sc0 ls42b">1.</div><div class="t m5c5 xc h5ca y5d0 ff2 fs5c6 fc0 sc0 ls42c">ou</div><div class="t m5c6 x2e h5cb y5d1 ff2c9 fs5c7 fc0 sc0 ls42d ws2cb">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m5c7 x13 h5cc y5d2 ff2 fs5c8 fc0 sc0 ls42e">TNF</div><div class="t m5c8 xcb h5cd y5d3 ff2 fs5c9 fc0 sc0 ls2">,</div><div class="t m5c9 x112 h5ce y5d4 ff2 fs5ca fc0 sc0 ls42f">de</div><div class="t m5ca xcf h5cf y5d5 ff2ca fs5cb fc0 sc0 ls430 ws2cc">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m5cb x3c h5d0 y5d6 ff2 fs5cc fc0 sc0 ls431 ws2cd">Fa<span class="blank"> </span>e<span class="blank"> </span>s</div><div class="t m5cc x75 h5d1 y5d7 ff2cb fs5cd fc0 sc0 ls2">\u2460</div><div class="t m5cd x73 h5d2 y5d8 ff57 fs5ce fc0 sc0 ls2">\u2460</div><div class="t m5ce x1b h5d3 y5d9 ff2 fs5cf fc0 sc0 ls432">que</div><div class="t m5cf x12 h5d4 y5da ff2cc fs5d0 fc0 sc0 ls433 ws2ce">rec<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>h<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>e<span class="blank"> </span>m</div><div class="t m5d0 xb7 h5d5 y5db ff2 fs5d1 fc0 sc0 ls434">as</div><div class="t m5d1 x2f h5d6 y5dc ff2cd fs5d2 fc0 sc0 ls435 ws2cf">moléculas</div><div class="t m5d2 x44 h5d7 y5dd ff2 fs5d3 fc0 sc0 ls436 ws2d0">Fa<span class="blank"> </span>s</div><div class="t m5d3 x3b h5d8 y5de ff2 fs5d4 fc0 sc0 ls2">-</div><div class="t m5d4 x8d h5d9 y5df ff2 fs5d5 fc0 sc0 ls2">L</div><div class="t m5d5 x3c h5da y5e0 ff2 fs5d6 fc0 sc0 ls437">ou</div><div class="t m5d6 xd6 h5db y5e1 ff57 fs5d7 fc0 sc0 ls2">\u2464</div><div class="t m5d7 x2d h5dc y5e2 ff2 fs5d8 fc0 sc0 ls438">as</div><div class="t m5d8 x85 h5dd y5e3 ff2ce fs5d9 fc0 sc0 ls439 ws2d1">portuárias</div><div class="t m5d9 xb2 h5de y5e4 ff2cf fs5da fc0 sc0 ls43a ws2d2">ativam</div><div class="t m5da xd9 h5df y5e5 ff2 fs5db fc0 sc0 ls43b">as</div><div class="t m5db x26 h5e0 y5e6 ff2d0 fs5dc fc0 sc0 ls43c ws2d3">oaspases</div><div class="t m5dc xff h5e1 y5e7 ff2 fs5dd fc0 sc0 ls2">8</div><div class="t m5dd x10 h5e2 y5e8 ff2 fs5de fc0 sc0 ls2">,</div><div class="t m5de x119 h5e3 y5e9 ff2d1 fs5df fc0 sc0 ls2">\u2466</div><div class="t m5df x2d h5e4 y5ea ff2 fs5e0 fc0 sc0 ls43d ws2d4">iniciadores</div><div class="t m5e0 xb0 h5e5 y5eb ff2 fs5e1 fc0 sc0 ls43e">da</div><div class="t m5e1 xd h5e6 y5ec ff2 fs5e2 fc0 sc0 ls43f">via</div><div class="t m5e2 x14 h5e7 y5ed ff2 fs5e3 fc0 sc0 ls440 ws2d5">ext<span class="blank"> </span>r<span class="blank"> </span>í<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>a</div><div class="t m5e3 x78 h5e8 y5ee ff2 fs5e4 fc0 sc0 ls2">.</div><div class="t m5e4 xee h5e9 y5ef ff2 fs5e5 fc0 sc0 ls2">(</div><div class="t m5e5 x6e h5ea y5f0 ff2 fs5e6 fc0 sc0 ls441 ws2d6">assim</div><div class="t m5e6 xaf h5eb y5f1 ff2d2 fs5e7 fc0 sc0 ls442">chamada</div><div class="t m5e7 x11a h5ec y5f2 ff2d3 fs5e8 fc0 sc0 ls443 ws2d7">justament<span class="blank _4"></span>e</div><div class="t m5e8 x42 h5ed y5f3 ff2d4 fs5e9 fc0 sc0 ls444 ws2d8">porque</div><div class="t m5e9 x27 h5ee y5f4 ff2 fs5ea fc0 sc0 ls445">os</div><div class="t m5ea xb1 h5ef y5f5 ff2d5 fs5eb fc0 sc0 ls446 ws2d9">rec<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m5eb x0 h5f0 y5f6 ff2 fs5ec fc0 sc0 ls447 ws2da">estão</div><div class="t m5ec x100 h5f1 y5f7 ff2d6 fs5ed fc0 sc0 ls448 ws2db">vol<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>s</div><div class="t m5ed x4a h5f2 y5f8 ff2d7 fs5ee fc0 sc0 ls449 ws2dc">para</div><div class="t m5ee x14 h5f3 y5f9 ff2d8 fs5ef fc0 sc0 ls44a ws2dd">fo<span class="blank"> </span>r<span class="blank"> </span>a</div><div class="t m5ef x1e h5f4 y5fa ff2d9 fs5f0 fc0 sc0 ls44b">da</div><div class="t m5f0 x11b h5f5 y5fb ff2da fs5f1 fc0 sc0 ls44c ws2de">membrana</div><div class="t m5f1 x1b h5f6 y5fc ff2db fs5f2 fc0 sc0 ls44d ws2df">plasmática</div><div class="t m5f2 xb0 h5f7 y5fd ff2 fs5f3 fc0 sc0 ls2">)</div><div class="t m5f3 xb h5f8 y5fe ff2 fs5f4 fc0 sc0 ls44e">c.</div><div class="t m5f4 x76 h5f9 y5ff ff2 fs5f5 fc0 sc0 ls44f">via</div><div class="t m5f5 x6a h5fa y600 ff2dc fs5f6 fc0 sc0 ls450 ws2e0">intrínseca</div><div class="t m5f6 x1 h5fb y601 ff2 fs5f7 fc0 sc0 ls2">+</div><div class="t m5f7 x9d h5fc y602 ff2 fs5f8 fc0 sc0 ls451">ira</div><div class="t m5f8 x52 h5fd y603 ff2dd fs5f9 fc0 sc0 ls452 ws2e1">wc<span class="blank"> </span>t<span class="blank"> </span>r<span class="blank"> </span>í<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>a</div><div class="t m5f9 x11c h5fe y604 ff2 fs5fa fc0 sc0 ls2">:</div><div class="t m5fa x1b h5ff y605 ff2 fs5fb fc0 sc0 ls2">I</div><div class="t m5fb x93 h600 y606 ff2 fs5fc fc0 sc0 ls2">.</div><div class="t m5fc x76 h601 y607 ff2de fs5fd fc0 sc0 ls453 ws2e2">Ta<span class="blank"> </span>n<span class="blank"> </span>t<span class="blank"> </span>o</div><div class="t m5fd xd4 h602 y608 ff2 fs5fe fc0 sc0 ls2">a</div><div class="t m5fe x59 h603 y609 ff2df fs5ff fc0 sc0 ls454 ws2e3">caspase</div><div class="t m5ff x11d h604 y60a ff2 fs600 fc0 sc0 ls2">8</div><div class="t m600 x15 h605 y60b ff2e0 fs601 fc0 sc0 ls2">(</div><div class="t m601 x7e h606 y60c ff2 fs602 fc0 sc0 ls455">via</div><div class="t m602 xf2 h607 y60d ff2e1 fs603 fc0 sc0 ls456 ws2e4">ext<span class="blank"> </span>r<span class="blank"> </span>í<span class="blank"> </span>n<span class="blank"> </span>s<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>a</div><div class="t m603 x45 h608 y60e ff2e2 fs604 fc0 sc0 ls2">)</div><div class="t m604 xa9 h609 y60f ff2e3 fs605 fc0 sc0 ls457 ws2e5">quanto</div><div class="t m605 x95 h60a y610 ff2 fs606 fc0 sc0 ls2">a</div><div class="t m606 xe5 h60b y611 ff2e4 fs607 fc0 sc0 ls458 ws2e6">coespase</div><div class="t m607 x96 h60c y612 ff2 fs608 fc0 sc0 ls2">9</div><div class="t m608 x119 h60d y613 ff2e5 fs609 fc0 sc0 ls2">(</div><div class="t m609 x38 h60e y614 ff2 fs60a fc0 sc0 ls459">via</div><div class="t m60a x1b h60f y615 ff2e6 fs60b fc0 sc0 ls45a ws2e7">intrínseca</div><div class="t m60b x1c h610 y616 ff2 fs60c fc0 sc0 ls2">)</div><div class="t m60c x11e h611 y617 ff2e7 fs60d fc0 sc0 ls45b">atiram</div><div class="t m60d x1 h612 y618 ff2 fs60e fc0 sc0 ls45c">as</div><div class="t m60e x77 h613 y619 ff2 fs60f fc0 sc0 ls45d ws2e8">caspases</div><div class="t m60f x1f h614 y61a ff2e8 fs610 fc0 sc0 ls45e ws2e9">exec<span class="blank"> </span>u<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank"> </span>a<span class="blank"> </span>s</div><div class="t m610 xc6 h615 y61b ff2 fs611 fc0 sc0 ls2">(</div><div class="t m611 xa4 h616 y61c ff2 fs612 fc0 sc0 ls45f">ou</div><div class="t m612 xc5 h617 y61d ff2e9 fs613 fc0 sc0 ls460 ws2ea">seja</div><div class="t m613 x34 h618 y61e ff2 fs614 fc0 sc0 ls2">,</div><div class="t m614 xbe h619 y61f ff2ea fs615 fc0 sc0 ls461 ws2eb">ambas</div><div class="t m615 x11f h61a y620 ff2 fs616 fc0 sc0 ls462">as</div><div class="t m616 xf5 h61b y621 ff2 fs617 fc0 sc0 ls463">vias</div><div class="t m617 x120 h61c y622 ff2 fs618 fc0 sc0 ls464 ws2ec">são</div><div class="t m618 x1b h61d y623 ff2 fs619 fc0 sc0 ls465 ws2ed">necessárias</div><div class="t m619 x11e h61e y624 ff2eb fs61a fc0 sc0 ls466 ws2ee">para</div><div class="t m61a x5b h61f y625 ff2ec fs61b fc0 sc0 ls467">que</div><div class="t m61b x11d h620 y626 ff2 fs61c fc0 sc0 ls40f ws2ef">ocorra</div><div class="t m61c x9e h621 y627 ff2ed fs61d fc0 sc0 ls468 ws2f0">apoptose</div><div class="t m61d x10 h622 y628 ff2ee fs61e fc0 sc0 ls2">)</div><div class="t m61e x1b h623 y629 ff2 fs61f fc0 sc0 ls469">I.</div><div class="t m61f x79 h624 y62a ff2ef fs620 fc0 sc0 ls46a ws2f1">Essas</div><div class="t m620 xbd h625 y62b ff2 fs621 fc0 sc0 ls46b ws2f2">carapaus</div><div class="t m621 xcc h626 y62c ff2f0 fs622 fc0 sc0 ls46c ws2f3">voa<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank"> </span>a<span class="blank"> </span>s</div><div class="t m622 x11b h627 y62d ff2 fs623 fc0 sc0 ls2">,</div><div class="t m623 x78 h628 y62e ff2f1 fs624 fc0 sc0 ls46d ws2f4">quando</div><div class="t m624 xd0 h629 y62f ff2f2 fs625 fc0 sc0 ls46e ws2f5">ativados</div><div class="t m625 x18 h62a y630 ff2 fs626 fc0 sc0 ls2">,</div><div class="t m626 x29 h62b y631 ff2 fs627 fc0 sc0 ls46f ws2f6">diriam</div><div class="t m627 xf1 h62c y632 ff2 fs628 fc0 sc0 ls470 ws2f7">numerosos</div><div class="t m628 x8f h62d y633 ff2f3 fs629 fc0 sc0 ls471 ws2f8">alvos</div><div class="t m629 x1a h62e y634 ff2 fs62a fc0 sc0 ls2">,</div><div class="t m62a x2d h62f y635 ff2f4 fs62b fc0 sc0 ls472 ws2f9">lev<span class="blank _4"></span>ando</div><div class="t m62b xca h630 y636 ff2 fs62c fc0 sc0 ls2">à</div><div class="t m62c xb4 h631 y637 ff2f5 fs62d fc0 sc0 ls473 ws2fa">ativação</div><div class="t m62d xc0 h632 y638 ff2 fs62e fc0 sc0 ls474 ws2fb">dos</div><div class="t m62e x5c h633 y639 ff2 fs62f fc0 sc0 ls475 ws2fc">nucleares</div><div class="t m62f xc4 h634 y63a ff2 fs630 fc0 sc0 ls2">,</div><div class="t m630 x10 h635 y63b ff2 fs631 fc0 sc0 ls476">que</div><div class="t m631 x9f h636 y63c ff2f6 fs632 fc0 sc0 ls477 ws2fd">degradam</div><div class="t m632 xf0 h637 y63d ff2 fs633 fc0 sc0 ls478">as</div><div class="t m633 xeb h638 y63e ff2f7 fs634 fc0 sc0 ls479 ws2fe">nuchopr<span class="blank _0"></span>otánas</div><div class="t m634 x2d h639 y63f ff2 fs635 fc0 sc0 ls2">e</div><div class="t m635 x93 h63a y640 ff2 fs636 fc0 sc0 ls2">o</div><div class="t m636 x76 h63b y641 ff2 fs637 fc0 sc0 ls47a ws2ff">DNA</div><div class="t m637 x39 h63c y642 ff2 fs638 fc0 sc0 ls2">,</div><div class="t m638 x86 h63d y643 ff2 fs639 fc0 sc0 ls47b ws300">além</div><div class="t m639 xb2 h63e y644 ff2 fs63a fc0 sc0 ls47c">de</div><div class="t m63a x65 h63f y645 ff2f8 fs63b fc0 sc0 ls47d ws301">degradar</div><div class="t m63b x7b h640 y646 ff2f9 fs63c fc0 sc0 ls47e ws302">também</div><div class="t m63c xce h641 y647 ff2 fs63d fc0 sc0 ls47f">os</div><div class="t m63d xd0 h642 y648 ff2fa fs63e fc0 sc0 ls480 ws303">componentes</div><div class="t m63e x34 h643 y649 ff2 fs63f fc0 sc0 ls481">da</div><div class="t m63f xd6 h644 y64a ff2fb fs640 fc0 sc0 ls482 ws304">matriz</div><div class="t m640 x107 h645 y64b ff2fc fs641 fc0 sc0 ls483 ws305">nuclear</div><div class="t m641 x10b h646 y64c ff2 fs642 fc0 sc0 ls2">e</div><div class="t m642 x2d h647 y64d ff2 fs643 fc0 sc0 ls484">do</div><div class="t m643 x57 h648 y64e ff2fd fs644 fc0 sc0 ls485 ws306">citoesquelet<span class="blank _4"></span>o</div><div class="t m644 xe9 h649 y64f ff2 fs645 fc0 sc0 ls2">,</div><div class="t m645 x5b h64a y650 ff2fe fs646 fc0 sc0 ls486 ws307">promo<span class="blank _4"></span>vendo</div><div class="t m646 x9e h64b y651 ff2 fs647 fc0 sc0 ls2">a</div><div class="t m647 x3b h64c y652 ff2ff fs648 fc0 sc0 ls410 ws308">fragment<span class="blank _0"></span>ação</div><div class="t m648 x106 h64d y653 ff2 fs649 fc0 sc0 ls487 ws309">das</div><div class="t m649 x114 h64e y654 ff300 fs64a fc0 sc0 ls488 ws30a">células</div><div class="t m64a x11f h64f y655 ff2 fs64b fc0 sc0 ls2">.</div><div class="t m64b x0 h650 y656 ff2 fs64c fc0 sc0 ls489">II.</div><div class="t m64c x85 h651 y657 ff2 fs64d fc0 sc0 ls48a">as</div><div class="t m64d xbc h652 y658 ff301 fs64e fc0 sc0 ls48b ws30b">células</div><div class="t m64e x41 h653 y659 ff302 fs64f fc0 sc0 ls48c ws30c">apopléticos</div><div class="t m64f x77 h654 y65a ff2 fs650 fc0 sc0 ls48d ws30d">atraem</div><div class="t m650 xc3 h655 y65b ff2 fs651 fc0 sc0 ls48e">os</div><div class="t m651 x108 h656 y65c ff303 fs652 fc0 sc0 ls48f ws30e">fag<span class="blank _2"> </span>ó<span class="blank"> </span>c<span class="blank"> </span>i<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>s</div><div class="t m652 x9f h657 y65d ff304 fs653 fc0 sc0 ls490 ws30f">pr<span class="blank _4"></span>oduzindo</div><div class="t m653 xd8 h658 y65e ff305 fs654 fc0 sc0 ls491 ws310">sinais</div><div class="t m654 x107 h659 y65f ff306 fs655 fc0 sc0 ls492 ws311">para</div><div class="t m655 xe6 h65a y660 ff2 fs656 fc0 sc0 ls493">que</div><div class="t m656 x121 h65b y661 ff2 fs657 fc0 sc0 ls2">a</div><div class="t m657 xb h65c y662 ff307 fs658 fc0 sc0 ls494">célula</div><div class="t m658 x62 h65d y663 ff308 fs659 fc0 sc0 ls495">seja</div><div class="t m659 x64 h65e y664 ff309 fs65a fc0 sc0 ls496 ws312">fa<span class="blank"> </span>g<span class="blank"> </span>ó<span class="blank"> </span>a<span class="blank"> </span>to<span class="blank"> </span>d<span class="blank"> </span>a</div><div class="t m65a x42 h65f y665 ff2 fs65b fc0 sc0 ls2">.</div><div class="t m65b x112 h660 y666 ff2 fs65c fc0 sc0 ls497">Em</div><div class="t m65c x7b h661 y667 ff30a fs65d fc0 sc0 ls498 ws313">células</div><div class="t m65d x84 h662 y668 ff30b fs65e fc0 sc0 ls499 ws314">apopléticos</div><div class="t m65e xf4 h663 y669 ff2 fs65f fc0 sc0 ls2">a</div><div class="t m65f xd7 h664 y66a ff30c fs660 fc0 sc0 ls49a ws315">fo<span class="blank"> </span>s<span class="blank"> </span>fa<span class="blank"> </span>t<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>i<span class="blank"> </span>t<span class="blank"> </span>s<span class="blank"> </span>e<span class="blank"> </span>r<span class="blank"> </span>e<span class="blank"> </span>.<span class="blank"> </span>n<span class="blank"> </span>o</div><div class="t m660 x96 h665 y66b ff2 fs661 fc0 sc0 ls49b ws316">mov<span class="blank _0"></span>e</div><div class="t m661 x118 h666 y66c ff2 fs662 fc0 sc0 ls2">-</div><div class="t m662 xa1 h667 y66d ff2 fs663 fc0 sc0 ls49c">se</div><div class="t m663 xb h668 y66e ff30d fs664 fc0 sc0 ls49d ws317">para</div><div class="t m664 xab h669 y66f ff30e fs665 fc0 sc0 ls49e ws318">fo<span class="blank"> </span>r<span class="blank"> </span>a</div><div class="t m665 x11a h66a y670 ff2 fs666 fc0 sc0 ls2">e</div><div class="t m666 xc2 h66b y671 ff2 fs667 fc0 sc0 ls2">é</div><div class="t m667 x4a h66c y672 ff2 fs668 fc0 sc0 ls49f ws319">exp<span class="blank"> </span>re<span class="blank"> </span>s<span class="blank"> </span>s<span class="blank"> </span>a</div><div class="t m668 x112 h66d y673 ff2 fs669 fc0 sc0 ls4a0">no</div><div class="t m669 x52 h66e y674 ff30f fs66a fc0 sc0 ls4a1 ws31a">fo<span class="blank"> </span>l<span class="blank"> </span>h<span class="blank"> </span>e<span class="blank"> </span>t<span class="blank"> </span>o</div><div class="t m66a xc4 h66f y675 ff310 fs66b fc0 sc0 ls4a2 ws31b">ext<span class="blank"> </span>e<span class="blank"> </span>r<span class="blank"> </span>n<span class="blank"> </span>o</div><div class="t m66b x98 h670 y676 ff311 fs66c fc0 sc0 ls4a3">da</div><div class="t m66c xc5 h671 y677 ff312 fs66d fc0 sc0 ls4a4 ws31c">membrana</div><div class="t m66d xd1 h672 y678 ff2 fs66e fc0 sc0 ls2">,</div><div class="t m66e x73 h673 y679 ff2 fs66f fc0 sc0 ls4a5 ws31d">onde</div><div class="t m66f x37 h674 y67a ff2 fs670 fc0 sc0 ls2">é</div><div class="t m670 xb h675 y67b ff313 fs671 fc0 sc0 ls4a6 ws31e">rec<span class="blank"> </span>o<span class="blank"> </span>n<span class="blank"> </span>h<span class="blank"> </span>e<span class="blank"> </span>c<span class="blank"> </span>i<span class="blank _2"> </span>d<span class="blank"> </span>a</div><div class="t m671 xc2 h676 y67c ff314 fs672 fc0 sc0 ls4a7 ws31f">pelos</div><div class="t m672 x5b h677 y67d ff315 fs673 fc0 sc0 ls4a8 ws320">macr<span class="blank _0"></span>óf<span class="blank _4"></span>agos</div><div class="t m673 xb5 h678 y67e ff2 fs674 fc0 sc0 ls2">,</div><div class="t m674 x9e h679 y67f ff316 fs675 fc0 sc0 ls4a9 ws321">lev<span class="blank _4"></span>ando</div><div class="t m675 x102 h67a y680 ff2 fs676 fc0 sc0 ls2">à</div><div class="t m676 x9f h67b y681 ff317 fs677 fc0 sc0 ls4aa ws322">nhogóator<span class="blank _0"></span>e</div><div class="t m677 xd5 h67c y682 ff2 fs678 fc0 sc0 ls4ab ws323">das</div><div class="t m678 x5 h67d y683 ff318 fs679 fc0 sc0 ls4ac ws324">células</div><div class="t m679 x117 h67e y684 ff319 fs67a fc0 sc0 ls4ad ws325">apostólicos</div><div class="t m67a x2d h67f y685 ff2 fs67b fc0 sc0 ls4ae ws326">IV<span class="blank _1"></span>.</div><div class="t m67b x57 h680 y686 ff2 fs67c fc0 sc0 ls4af">no</div><div class="t m67c xab h681 y687 ff2 fs67d fc0 sc0 ls4b0 ws327">corpo</div><div class="t m67d x6b h682 y688 ff31a fs67e fc0 sc0 ls4b1 ws328">apoplético</div><div class="t m67e x6d h683 y689 ff31b fs67f fc0 sc0 ls4b2 ws329">secreto</div><div class="t m67f x52 h684 y68a ff31c fs680 fc0 sc0 ls4b3 ws32a">fa<span class="blank"> </span>to<span class="blank"> </span>re<span class="blank"> </span>s</div><div class="t m680 xb8 h685 y68b ff31d fs681 fc0 sc0 ls4b4 ws32b">solúveis</div><div class="t m681 x82 h686 y68c ff2 fs682 fc0 sc0 ls4b5">que</div><div class="t m682 x71 h687 y68d ff2 fs683 fc0 sc0 ls4b6 ws32c">rec<span class="blank"> </span>r<span class="blank"> </span>u<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>m</div><div class="t m683 xdb h688 y68e ff2 fs684 fc0 sc0 ls4b7">os</div><div class="t m684 x6 h689 y68f ff31e fs685 fc0 sc0 ls4b8 ws32d">fag<span class="blank"> </span>ó<span class="blank"> </span>c<span class="blank"> </span>i<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>s</div><div class="t m685 x22 h68a y690 ff2 fs686 fc0 sc0 ls2">,</div><div class="t m686 x8f h68b y691 ff2 fs687 fc0 sc0 ls2">o</div><div class="t m687 x120 h68c y692 ff2 fs688 fc0 sc0 ls4b9">que</div><div class="t m688 x2d h68d y693 ff31f fs689 fc0 sc0 ls411 ws32e">f<span class="blank _4"></span>acilita<span class="blank _4"></span></div><div class="t m689 x94 h68e y694 ff2 fs68a fc0 sc0 ls2">a</div><div class="t m68a xd4 h68f y695 ff320 fs68b fc0 sc0 ls4ba ws32f">rem<span class="blank"> </span>o<span class="blank"> </span>ç<span class="blank"> </span>ã<span class="blank"> </span>o</div><div class="t m68b xe1 h690 y696 ff321 fs68c fc0 sc0 ls4bb ws330">imediata</div><div class="t m68c x89 h691 y697 ff322 fs68d fc0 sc0 ls4bc ws331">dessas</div><div class="t m68d xd0 h692 y698 ff323 fs68e fc0 sc0 ls4bd ws332">células</div><div class="t m68e x4 h693 y699 ff324 fs68f fc0 sc0 ls4be ws333">mor<span class="blank"> </span>tas</div><div class="t m68f xeb h694 y69a ff2 fs690 fc0 sc0 ls4bf ws334">antes</div><div class="t m690 x107 h695 y69b ff2 fs691 fc0 sc0 ls4c0">que</div><div class="t m691 x115 h696 y69c ff325 fs692 fc0 sc0 ls4c1 ws335">sofram</div><div class="t m692 x2d h697 y69d ff2 fs693 fc0 sc0 ls4c2">uma</div><div class="t m693 xbc h698 y69e ff326 fs694 fc0 sc0 ls4c3 ws336">segunda</div><div class="t m694 xd h699 y69f ff327 fs695 fc0 sc0 ls4c4 ws337">lesão</div><div class="t m695 xc0 h69a y6a0 ff2 fs696 fc0 sc0 ls4c5">de</div><div class="t m696 xd2 h69b y6a1 ff328 fs697 fc0 sc0 ls4c6 ws338">membrana</div><div class="t m697 xa8 h69c y6a2 ff2 fs698 fc0 sc0 ls2">e</div><div class="t m698 x53 h69d y6a3 ff329 fs699 fc0 sc0 ls4c7 ws339">liberem</div><div class="t m699 xa5 h69e y6a4 ff2 fs69a fc0 sc0 ls4c8">seus</div><div class="t m69a xbe h69f y6a5 ff32a fs69b fc0 sc0 ls4c9 ws33a">conteúdos</div><div class="t m69b x74 h6a0 y6a6 ff32b fs69c fc0 sc0 ls4ca ws33b">celulares</div><div class="t m69c x48 h6a1 y6a7 ff2 fs69d fc0 sc0 ls2">.</div><div class="t m69d xb h6a2 y6a8 ff2 fs69e fc0 sc0 ls4cb ws33c">Esses</div><div class="t m69e xbc h6a3 y6a9 ff32c fs69f fc0 sc0 ls4cc ws33d">fa<span class="blank"> </span>to<span class="blank"> </span>r<span class="blank"> </span>e<span class="blank"> </span>s</div><div class="t m69f x8c h6a4 y6aa ff32d fs6a0 fc0 sc0 ls4cd ws33e">solúveis</div><div class="t m6a0 xf h6a5 y6ab ff32e fs6a1 fc0 sc0 ls4ce ws33f">podem</div><div class="t m6a1 xc3 h6a6 y6ac ff2 fs6a2 fc0 sc0 ls4cf">ser</div><div class="t m6a2 x3c h6a7 y6ad ff32f fs6a3 fc0 sc0 ls4d0 ws340">glicopr<span class="blank _0"></span>oteína</div><div class="t m6a3 x106 h6a8 y6ae ff2 fs6a4 fc0 sc0 ls4d1 ws341">adesivas</div><div class="t m6a4 xf8 h6a9 y6af ff2 fs6a5 fc0 sc0 ls2">,</div><div class="t m6a5 x6 h6aa y6b0 ff2 fs6a6 fc0 sc0 ls4d2 ws342">por</div><div class="t m6a6 x4e h6ab y6b1 ff330 fs6a7 fc0 sc0 ls4d3 ws343">womp<span class="blank _2"> </span>lo</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf9" class="pf w0 hc" data-page-no="9"><div class="pc pc9 w0 hc"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 hd" alt="" src="https://files.passeidireto.com/51533acb-e862-4b1c-8d7d-0950061de2b5/bg9.png"><div class="t m6a7 xb h6ac y6b2 ff2 fs6a8 fc0 sc0 ls2">\u2022</div><div class="t m6a8 x122 h6ad y6b3 ff331 fs6a9 fc0 sc0 ls4d4 ws344">Resumi<span class="blank _2"> </span>ndo</div><div class="t m6a9 x123 h6ae y6b4 ff2 fs6aa fc0 sc0 ls2">:</div><div class="t m6aa x2d h6af y6b5 ffc fs6ab fc0 sc0 ls2">\u21b3</div><div class="t m6ab x49 h6b0 y6b6 ff332 fs6ac fc0 sc0 ls4d5 ws345">lesão</div><div class="t m6ac xca h6b1 y6b7 ff333 fs6ad fc0 sc0 ls4d6 ws346">erierrrsível</div><div class="t m6ad x9d h6b2 y6b8 ff2 fs6ae fc0 sc0 ls2">:</div><div class="t m6ae xb h6b3 y6b9 ffc fs6af fc0 sc0 ls2">\u21b3</div><div class="t m6af x79 h6b4 y6ba ff2 fs6b0 fc0 sc0 ls4d7 ws347">necrose</div><div class="t m6b0 x11e h6b5 y6bb ff57 fs6b1 fc0 sc0 ls2">×</div><div class="t m6b1 xb7 h6b6 y6bc ff334 fs6b2 fc0 sc0 ls4d8 ws348">apoptose</div><div class="t m6b2 xf h6b7 y6bd ff2 fs6b3 fc0 sc0 ls2">:</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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