How are macrophages activated in tumor immunity?
a) Macrophages are directly activated by tumor cells through the recognition of surface antigens...
How are macrophages activated in tumor immunity?
a) Macrophages are directly activated by tumor cells through the recognition of surface antigens and by IFN-γ produced by tumor-specific T cells. b) Macrophages are activated by the release of lysosomal enzymes, reactive oxygen species, and nitric oxide, which are the same mechanisms used to destroy infectious organisms. c) Macrophages are activated by the recognition of tumor antigens presented by APCs and by the production of IFN-γ by tumor-specific T cells. d) Macrophages are activated by the recognition of tumor antigens presented by APCs and by the release of lysosomal enzymes, reactive oxygen species, and nitric oxide.
A resposta correta é a alternativa c) Macrófagos são ativados pelo reconhecimento de antígenos tumorais apresentados por APCs (células apresentadoras de antígenos) e pela produção de IFN-γ por células T específicas para o tumor.
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