Which TIMP is a mannose-rich glycoprotein with a molecular mass of 23 kDa and is involved in abnormal ECM accumulation either directly or indirectly through inhibition of MMP-14 or activation of MMP-2?
A) TIMP-1
B) TIMP-2
C) TIMP-3
D) TIMP-4
E) None of the above

Question

Which TIMP is a mannose-rich glycoprotein with a molecular mass of 23 kDa and is involved in abnormal ECM accumulation either directly or indirectl...

Ed · Answer

Para responder a essa pergunta, precisamos analisar as opções de TIMPs (Inibidores de Metaloproteinases da Matriz) e suas características.

A questão menciona um TIMP que é uma glicoproteína rica em manose com uma massa molecular de 23 kDa e que está envolvida na acumulação anormal da matriz extracelular (ECM), inibindo a MMP-14 ou ativando a MMP-2.

Vamos analisar as alternativas:

A) TIMP-1 - Tem um papel importante na regulação das metaloproteinases, mas não é especificamente conhecido por ser uma glicoproteína rica em manose.

B) TIMP-2 - É conhecido por interagir com MMP-2 e MMP-14, e tem uma massa molecular próxima de 23 kDa. É frequentemente associado à regulação da ECM.

C) TIMP-3 - Tem uma massa molecular diferente e não é especificamente descrito como uma glicoproteína rica em manose.

D) TIMP-4 - Também tem uma massa molecular diferente e não é a resposta correta.

E) None of the above - Não se aplica, pois TIMP-2 parece ser a resposta correta.

Com base na análise, a alternativa correta é: **B) TIMP-2**.

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Papel das Metaloproteinases na DPOC

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Essa pergunta também está no material:

Papel das Metaloproteinases na DPOC

Which of the following MMPs is a collagenase that degrades collagen and is significantly associated with COPD?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is known to be involved in COPD and is expressed by neutrophils and macrophages?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is both a collagenase and an elastase and is critical in lung destruction during the development of COPD?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is expressed by macrophages and CD68-positive cells in the lungs and is associated with small airway disease and the severity of emphysema?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is a potent elastase in humans and is expressed by the mucosal epithelium and macrophages in humans?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-7
E) MMP-10

Which MMP is significantly elevated in stable COPD patients compared with asthmatic patients and controls, suggesting it as a potential biomarker for COPD?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is an elastase expressed in both mice and humans, and its role in COPD remains questionable due to controversial data?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is involved in emphysema and its role in COPD remains unclear?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP has been shown to have a proinflammatory function and is involved in alveolar destruction and the pathogenesis of COPD?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is a major inhibitor of ECM remodeling that mediates fibrosis and is a COPD regulator that strongly influences tissue homeostasis?
A) TIMP-1
B) TIMP-2
C) TIMP-3
D) TIMP-4
E) None of the above

Mais conteúdos dessa disciplina

Terapia Respiratória

Papel das Metaloproteinases na DPOC

Respostas

Ainda com dúvidas?

Essa pergunta também está no material:

Papel das Metaloproteinases na DPOC

Which of the following MMPs is a collagenase that degrades collagen and is significantly associated with COPD?A) MMP-1B) MMP-8C) MMP-13D) MMP-3E) MMP-10

Which MMP is known to be involved in COPD and is expressed by neutrophils and macrophages?A) MMP-1B) MMP-8C) MMP-13D) MMP-3E) MMP-10

Which MMP is both a collagenase and an elastase and is critical in lung destruction during the development of COPD?A) MMP-1B) MMP-8C) MMP-13D) MMP-3E) MMP-10

Which MMP is expressed by macrophages and CD68-positive cells in the lungs and is associated with small airway disease and the severity of emphysema?A) MMP-1B) MMP-8C) MMP-13D) MMP-3E) MMP-10

Which MMP is a potent elastase in humans and is expressed by the mucosal epithelium and macrophages in humans?A) MMP-1B) MMP-8C) MMP-13D) MMP-7E) MMP-10

Which MMP is significantly elevated in stable COPD patients compared with asthmatic patients and controls, suggesting it as a potential biomarker for COPD?A) MMP-2B) MMP-9C) MMP-14D) MMP-12E) MMP-28

Which MMP is an elastase expressed in both mice and humans, and its role in COPD remains questionable due to controversial data?A) MMP-2B) MMP-9C) MMP-14D) MMP-12E) MMP-28

Which MMP is involved in emphysema and its role in COPD remains unclear?A) MMP-2B) MMP-9C) MMP-14D) MMP-12E) MMP-28

Which MMP has been shown to have a proinflammatory function and is involved in alveolar destruction and the pathogenesis of COPD?A) MMP-2B) MMP-9C) MMP-14D) MMP-12E) MMP-28

Which MMP is a major inhibitor of ECM remodeling that mediates fibrosis and is a COPD regulator that strongly influences tissue homeostasis?A) TIMP-1B) TIMP-2C) TIMP-3D) TIMP-4E) None of the above

Mais conteúdos dessa disciplina

Which of the following MMPs is a collagenase that degrades collagen and is significantly associated with COPD?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is known to be involved in COPD and is expressed by neutrophils and macrophages?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is both a collagenase and an elastase and is critical in lung destruction during the development of COPD?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is expressed by macrophages and CD68-positive cells in the lungs and is associated with small airway disease and the severity of emphysema?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-3
E) MMP-10

Which MMP is a potent elastase in humans and is expressed by the mucosal epithelium and macrophages in humans?
A) MMP-1
B) MMP-8
C) MMP-13
D) MMP-7
E) MMP-10

Which MMP is significantly elevated in stable COPD patients compared with asthmatic patients and controls, suggesting it as a potential biomarker for COPD?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is an elastase expressed in both mice and humans, and its role in COPD remains questionable due to controversial data?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is involved in emphysema and its role in COPD remains unclear?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP has been shown to have a proinflammatory function and is involved in alveolar destruction and the pathogenesis of COPD?
A) MMP-2
B) MMP-9
C) MMP-14
D) MMP-12
E) MMP-28

Which MMP is a major inhibitor of ECM remodeling that mediates fibrosis and is a COPD regulator that strongly influences tissue homeostasis?
A) TIMP-1
B) TIMP-2
C) TIMP-3
D) TIMP-4
E) None of the above