falasca2012_Vascular dysfunction in HIV-infected patients.

Prévia do material em texto

Poster Abstract � P216
Vascular dysfunction in HIV-infected patients
Falasca, K1; Ucciferri, C2; Tatasciore, A3; Tommasi, R3; De Caterina, R3; Pizzigallo, E1 and Vecchiet, J1
1Department of Infectious Disease, ‘‘G. d’Annunzio’’ University, Chieti, Italy. 2Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
3Department of Cardiology, ‘‘G. d’Annunzio’’ University, Chieti, Italy.
Atherosclerotic cardiovascular disease is an increasing concern for patients with human immunodeficiency virus (HIV) infection.
We investigated carotid intima-media thickness (IMT), flow-mediated dilation (FMD), pulse wave velocity (PWV) and the
augmentation index (AIx), evaluated as indices of subclinical atherosclerosis, in HIV-infected patients compared to uninfected
subjects. We enrolled 80 HIV-infected patients, 68 of whom treated with combined antiretroviral therapy (cART) and 12 therapy-
naı¨ve, matched with 82 healthy subjects for age, systolic and diastolic blood pressure. We investigated IMT, FMD, PWV, AIx,
viro-immunological parameters, inflammatory markers, microalbuminuria and other biochemical parameters. Compared with
uninfected subjects, HIV-infected subjects had higher IMT, PWV and AIx values (all P�0.0001); and lower FMD (P�0.001).
In the HIV� group, naı¨ve patients had statistically lower levels of IMT (P�0.02), and AIx (P�0.042) and higher FMD (P�0.032)
compared with cART-treated patients. In the HIV�group, IMT values was significantly related to the number of CD4�
(r��0.31, P�0.008) and CD8� cells (r�0.261, P�0.025), interleukin-6 (r�0.284, P�0.015) and endothelin-1 (r�0.302,
P�0.009). Vascular dysfunction evaluated as IMT, FMD and arterial stiffness is increased in HIV-infected subjects than in healthy
subjects. Furthermore, cART-treated patients showed higher IMT and AIx and lower FMD values than naı¨ve patients. Our data
support the hypothesis that both HIV infection and cART treatment are risk factors for accelerated arteriosclerosis.
Published 11 November 2012
Copyright:– 2012 Falasca K et al; licensee International AIDS Society. This is an open access article distributed under the terms of the Creative Commons Attribution
License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
is properly cited.
Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection
Falasca K et al. Journal of the International AIDS Society 2012, 15(Suppl 4):18124
http://www.jiasociety.org/index.php/jias/article/view/18124 | http://dx.doi.org/10.7448/IAS.15.6.18124
1