<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg1.png"><div class="c x1 y1 w2 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Provienen del origen de las células por el <span class="blank _0"></span>proceso de Hematopoyesis.</div></div><div class="c x1 y3 w3 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">HEMATOPO<span class="blank _0"></span>YESIS. </div></div><div class="c x3 y4 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">(Hemato = sangre, poyesis = génesis/generac<span class="blank _0"></span>ión). Generación de las células de la </div></div><div class="c x3 y5 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws0">sangre.</div></div><div class="c x4 y6 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y8 w4 h8"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">Proce<span class="blank _0"></span>so de formación, desarrollo y madura<span class="blank _0"></span>ción de los eleme<span class="blank _0"></span>ntos celulares de<span class="blank _0"></span> la </div></div><div class="c x3 y9 w4 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws1">sangre.</div></div><div class="c x4 ya w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 yb w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Plaqueta<span class="blank _0"></span>s.<span class="blank _1"> </span>Son fragmentos de la membrana de una cé<span class="blank _0"></span>lula que es la que da origen a las </div></div><div class="c x1 yc w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">plaquetas (megacariocitos<span class="ls1">).</span></div></div><div class="c x1 yd w7 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">Generación<span class="blank _2"> </span> <span class="blank _0"></span>de células sanguíneas.</div></div><div class="c x1 ye w8 ha"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Medula ósea.<span class="blank"> </span>Donde se lleva a cabo el proce<span class="blank _0"></span>so de generación de la sangre. Proce<span class="blank _0"></span>so </div></div><div class="c x1 yf w8 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">hematopoyét<span class="blank _0"></span>ico. <span class="blank _2"> </span>Trabaja y genera células sanguíneas para<span class="blank _0"></span> cubrir la demanda del organismo.</div></div><div class="c x1 y10 w9 h8"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">Diariamente<span class="blank _0"></span> se producen 2x10^7 células B <span class="blank _0"></span>en la médula ósea <span class="blank _0"></span>del ratón, 10% sale <span class="blank _0"></span>a periferia </div></div><div class="c x1 y11 w9 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">y madura<span class="blank _0"></span> en el bazo y únicament<span class="blank _0"></span>e 1<span class="blank _2"> </span>-3% logra <span class="blank _0"></span>entra<span class="blank _0"></span>r al <span class="blank _2"> </span>poll LB maduros (madura<span class="blank _0"></span>r y </div></div><div class="c x1 y12 w9 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">convert<span class="blank _0"></span>irse en una célula funcional, hablamos <span class="blank _0"></span>de 20 mil a 60 mil).</div></div><div class="c x1 y13 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">A pesar de que la medula produce muchas c<span class="blank _0"></span>élulas, hay mecanismos durante el tra<span class="blank _0"></span>yecto <span class="blank _2"> </span>de la </div></div><div class="c x1 y14 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">maduración que van a ir eliminando a c<span class="blank _0"></span>élulas hasta que quede un número que logre pasar </div></div><div class="c x1 y15 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">esos mecanismos y logre madurar.</div></div><div class="c x1 y16 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Esos mecanismos<span class="blank"> </span>lo que buscan es lograr que salgan a la madurac<span class="blank _0"></span>ión células eficientes y </div></div><div class="c x1 y17 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">funcionales para evitar enfer<span class="blank _0"></span>medades.</div></div><div class="c x1 y18 wb h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws2">HEMATOPO<span class="blank _0"></span>YESIS.</div></div><div class="c x1 y19 w8 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Comienza en el proceso de la formación de un individuo. Desde que<span class="blank _0"></span> se forma el <span class="blank _2"> </span>saco vitelino</div></div><div class="c x1 y1a w8 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">ya se notan los primeros islotes de cé<span class="blank _0"></span>lulas hematopoyét<span class="blank _0"></span>icas <span class="blank _2"> </span>que forman células sanguíneas. </div></div><div class="c x3 y1b w4 h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">Primeros <span class="ff4">3 meses. Primer<span class="blank _2"> </span>os órganos <span class="blank _0"></span>hematopoyéti<span class="blank _2"> </span>cos: Hígado, Bazo, y Riñón.</span></div></div><div class="c x4 y1c w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y1d wc h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws4">4 meses. Se comi<span class="blank _2"> </span>enza <span class="blank _0"></span>a prod<span class="blank _2"> </span>ucir<span class="blank _2"> </span> <span class="blank _3"></span>la hematopo<span class="blank _2"> </span>yesis <span class="blank _3"></span>en<span class="blank _2"> </span> la medul<span class="blank _2"> </span>a <span class="blank _0"></span>ósea, <span class="blank _0"></span>en los hu<span class="blank _2"> </span>esos </div></div><div class="c x3 y1e wc h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws4">largos.<span class="blank _2"> </span> <span class="blank _0"></span>El hígado<span class="blank _2"> </span>, <span class="blank _0"></span>bazo y riñón<span class="blank _2"> </span> <span class="blank _3"></span>p<span class="blank _2"> </span>asan a<span class="blank _0"></span> segun<span class="blank _2"> </span>do <span class="blank _0"></span>térmi<span class="blank _2"> </span>no. </div></div><div class="c x4 y1f w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y20 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">En una etapa adulta en qué situación ocurre<span class="blank _0"></span> la <span class="blank _2"> </span>hematopoyesis del hígado<span class="blank"> </span>es cuando hay falla </div></div><div class="c x1 y21 wa h2"><div class="t m0 x2 hb y22 ff1 fs0 fc0 sc0 ls0 ws4">en la medula ósea. Cuando hay una <span class="ff4">anemi<span class="blank _2"> </span>a <span class="blank _0"></span>aplásica<span class="ff1">,<span class="blank _2"> </span> o una </span>aplasia total<span class="blank"> </span><span class="ff1">donde no ha<span class="blank _0"></span>y </span></span></div></div><div class="c x1 y23 wa h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">ningún precursor de las células sanguíneas circulante<span class="blank _0"></span>s, la medula ósea no funciona. Ahí es </div></div><div class="c x1 y24 wa hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">donde el hígado recue<span class="blank _0"></span>rda qu<span class="blank _2"> </span>e tuvo act<span class="blank _0"></span>ividad hematopoyética y trat<span class="blank _0"></span>a de <span class="blank _2"> </span>compensarlo pero </div></div><div class="c x1 y25 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">también termina afec<span class="blank _0"></span>tándose. </div></div><div class="c x1 y26 wd hd"><div class="t m0 x2 h5 y27 ff2 fs1 fc0 sc0 ls0 ws4"><span class="fc2 sc0">R</span><span class="fc2 sc0">A</span><span class="fc2 sc0">T</span><span class="fc2 sc0">Ó</span><span class="fc2 sc0">N. </span></div></div><div class="c x1 y28 we he"><div class="t m0 x2 hf y29 ff2 fs3 fc0 sc0 ls0 ws4">¿CÓMO SE ORIGINAN LAS <span class="blank _3"></span>CÉLULAS DEL SISTEMA </div></div><div class="c x1 y2a we h10"><div class="t m0 x2 hf y29 ff2 fs3 fc0 sc0 ls0 ws3">INMUNOLÓGICO?</div></div><div class="c x1 y2b wf h11"><div class="t m0 x2 h12 y2c ff1 fs4 fc1 sc0 ls0 ws4">viernes, 4 de mar<span class="blank _0"></span>zo de 202<span class="blank _0"></span>2</div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>1</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x9 y2f w11 h15" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg2.png"><div class="c x1 y30 wd h16"><div class="t m0 x2 h17 y2 ff2 fs6 fc0 sc0 ls0 ws4">RATÓN. </div></div><div class="c x1 y31 w12 h18"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">En el saco vitelino se observan Hemangioblastos<span class="blank"> </span>que dan origen a células epiteliales y a toda </div></div><div class="c x1 y32 w12 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">la línea de las cé<span class="blank _0"></span>lulas s<span class="blank _2"> </span>anguíneas roja<span class="blank _0"></span>s (eritrocitos). Después apare<span class="blank _0"></span>cen l<span class="blank _2"> </span>a <span class="blank _2"> </span>aorta, gónadas, </div></div><div class="c x1 y33 w12 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">mesodermos (AGM)<span class="blank"> </span>permite la genera<span class="blank _0"></span>ción de otros precursores hematopoyét<span class="blank _0"></span>icos <span class="blank _2"> </span>como </div></div><div class="c x1 y34 w12 h19"><div class="t m0 x2 h3 y35 ff1 fs0 fc0 sc0 ls0 ws4">células madre hemat<span class="blank _0"></span>opoyéticas y <span class="blank _2"> </span>siguen produciendo c<span class="blank _0"></span>élulas epiteliales . Las HSC<span class="blank _0"></span> (células </div></div><div class="c x1 y36 w12 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">madre hematopoyé<span class="blank _0"></span>ticas) <span class="blank _2"> </span>van a tene<span class="blank _0"></span>r <span class="blank _2"> </span>capacidad de autorre<span class="blank _0"></span>novarse o diferenciarse (puede </div></div><div class="c x1 y37 w12 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">diferenciarse a una et<span class="blank _0"></span>apa madura o <span class="blank _2"> </span>puede gene<span class="blank _0"></span>rar otra célula idéntica a ella) si se difere<span class="blank _0"></span>ncia </div></div><div class="c x1 y38 w12 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">puede dar origen a progenitores sanguíneos (aún son t<span class="blank _0"></span>empranos en esta etapa).</div></div><div class="c x3 y39 w13 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Gónadas (testículos, ovarios).</div></div><div class="c x4 y3a w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y3b w14 h18"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">A los 10.5 días de la gestación sigue pre<span class="blank _0"></span>sente la AGM. Hígado feta<span class="blank _0"></span>l comienza l<span class="blank _2"> </span>a producción </div></div><div class="c x1 y3c w14 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">de las células sanguíneas. Se forman más progenitor<span class="blank _0"></span>es y se van a ir diferenciando hacia un </div></div><div class="c x1 y3d w14 h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">linaje celular (progenitores mieloides comunes CMP<span class="blank _0"></span> , progenitores linfoides<span class="blank _2"> </span> <span class="blank _0"></span>comunes CLP<span class="blank _0"></span> </div></div><div class="c x1 y3e w14 hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">que a su vez dan origen a la línea de los <span class="blank _0"></span>eritrocit<span class="blank _0"></span>os MEP ,<span class="blank _2"> </span> granulocitos y monocitos GMP y de </div></div><div class="c x1 y3f w14 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">los linfocitos B y T<span class="ls1">).</span></div></div><div class="c x1 y40 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">A los 13.5 días hígado sigue teniendo a<span class="blank _0"></span>ctividad hematopoyética<span class="blank _0"></span>. <span class="blank _2"> </span>Comienzan a apare<span class="blank _0"></span>cer </div></div><div class="c x1 y41 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">estructura<span class="blank _0"></span>s <span class="blank _2"> </span>óseas y ya se puede llevar a<span class="blank _0"></span> cabo la hematopoyesis en una etapa adulta.</div></div><div class="c x1 y42 wa h18"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Las HSC<span class="blank _0"></span> <span class="blank _2"> </span>entran en una actividad de reposo, no es necesario que se diferencien <span class="blank _0"></span>para evitar </div></div><div class="c x1 y43 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">sobreproducción. Se diferencian HSC un poco más específicas<span class="blank"> </span>para los diferentes linajes de la </div></div><div class="c x1 y44 wa h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">circulación sanguínea como los<span class="blank"> </span>linf<span class="blank _2"> </span>ocitos <span class="blank _0"></span>b, t, granulocitos, monocit<span class="blank _0"></span>os, eritrocitos, </div></div><div class="c x1 y45 wa h19"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">megacar<span class="blank _0"></span>iocitos. </div></div><div class="c x1 y46 w15 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">PEZ ZEBRA.</div></div><div class="c x1 y47 w16 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Hemat<span class="blank _0"></span>opoyesis <span class="blank _2"> </span>ocurre más rápido. Comienza a formarse una e<span class="blank _0"></span>structura<span class="blank _0"></span> <span class="blank _2"> </span>simi<span class="blank _2"> </span>lar <span class="blank _0"></span>a la del saco </div></div><div class="c x1 y48 w16 h1a"><div class="t m0 x2 h3 y49 ff1 fs0 fc0 sc0 ls0 ws4"><span class="fc2 sc0">vi</span><span class="fc2 sc0">t</span><span class="fc2 sc0">e</span><span class="fc2 sc0">l</span><span class="fc2 sc0">i</span><span class="fc2 sc0">no </span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">l</span><span class="fc2 sc0">a</span><span class="fc2 sc0">s</span><span class="fc2 sc0"> </span><span class="fc2 sc0">20</span><span class="fc2 sc0"> </span><span class="fc2 sc0">hora</span><span class="fc2 sc0">s</span><span class="fc2 sc0"> </span><span class="fc2 sc0">de</span><span class="fc2 sc0"> </span><span class="fc2 sc0">qu</span><span class="fc2 sc0">e</span><span class="fc2 sc0"> </span><span class="fc2 sc0">c</span><span class="fc2 sc0">omi</span><span class="fc2 sc0">e</span><span class="fc2 sc0">nz</span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">l</span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="blank _0"></span><span class="fc2 sc0">ge</span><span class="fc2 sc0">s</span><span class="fc2 sc0">t</span><span class="fc2 sc0">a</span><span class="fc2 sc0">c</span><span class="fc2 sc0">i</span><span class="fc2 sc0">ón.</span><span class="fc2 sc0"> </span><span class="fc2 sc0">P</span><span class="fc2 sc0">os</span><span class="fc2 sc0">t</span><span class="fc2 sc0">e</span><span class="fc2 sc0">r</span><span class="fc2 sc0">i</span><span class="fc2 sc0">or</span><span class="fc2 sc0">me</span><span class="fc2 sc0">nt</span><span class="blank _0"></span><span class="fc2 sc0">e</span><span class="fc2 sc0"> </span><span class="fc2 sc0">s</span><span class="blank _2"> </span><span class="fc2 sc0">e</span><span class="fc2 sc0"> </span><span class="fc2 sc0">f</span><span class="fc2 sc0">or</span><span class="fc2 sc0">ma</span><span class="fc2 sc0">n </span><span class="fc2 sc0">l</span><span class="fc2 sc0">a</span><span class="fc2 sc0">s</span><span class="fc2 sc0"> </span></div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>2</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 y4a w17 h1b" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg3.png"><div class="c x1 y4b w16 h1c"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">vitelino a las 20 horas de que comienza la <span class="blank _0"></span>gestación. Posteriorment<span class="blank _0"></span>e s<span class="blank _2"> </span>e forman las </div></div><div class="c x1 y4c w16 h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">estructura<span class="blank _0"></span>s <span class="blank _2"> </span>de AGM a las 36 horas. Día 4 se e<span class="blank _0"></span>stablece un poco más ya hay células </div></div><div class="c x1 y4d w16 hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">hematopoyét<span class="blank _0"></span>icas <span class="blank _2"> </span>que producen células sanguíneas. Día 6 Timo y Riñones<span class="blank"> </span>actividad </div></div><div class="c x1 y4e w16 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">hematopoyét<span class="blank _0"></span>ica. <span class="blank _2"> </span>Timo<span class="blank"> </span>desde los<span class="blank _2"> </span> <span class="blank _0"></span>3 hasta los 6 días órgano hematopoyé<span class="blank _0"></span>tico.</div></div><div class="c x1 y4f w18 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">Arquitectura de la médula ósea. </div></div><div class="c x3 y50 w19 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Medula ósea.<span class="blank"> </span>Tejido que se encuentra adent<span class="blank _0"></span>ro de <span class="blank _2"> </span>los huesos. Los huesos largos t<span class="blank _0"></span>ienen </div></div><div class="c x3 y51 w19 h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws4">mayor activid<span class="blank _2"> </span>ad hematopoyética<span class="blank _4"> </span><span class="ff1">(fémur, cader<span class="blank _0"></span>a, <span class="blank _2"> </span>crestas iliacas, c<span class="blank _0"></span>olumna<span class="blank _2"> </span><span class="ls1">).</span></span></div></div><div class="c x4 y52 w5 h1d"><div class="t m0 x2 h1e y53 ff3 fs2 fc0 sc0 ls0">-</div></div><div class="c x1 y54 w1a h18"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">Conformada por:<span class="blank"> </span>Recubierta por capas del hueso (cartílagos art<span class="blank _0"></span>iculares<span class="ls1">) </span><span class="ff4 ws5">ir<span class="blank _2"> </span>rigad<span class="blank _2"> </span>a<span class="blank"> </span></span>por venas y </div></div><div class="c x1 y55 w1a h8"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">arte<span class="blank _0"></span>rias.<span class="blank"> </span>Es<span class="blank _2"> </span>a <span class="ff4 ws6">ir<span class="blank _2"> </span>rigaci<span class="blank _2"> </span>ón<span class="blank"> </span></span>permite que tenga los <span class="ff4">n<span class="blank _2"> </span>utrie<span class="blank _2"> </span>ntes <span class="blank _3"></span>ne<span class="blank _2"> </span>cesario<span class="blank _2"> </span>s<span class="blank"> </span><span class="ff1">y <span class="blank _0"></span>también permite<span class="blank _0"></span> la </span></span></div></div><div class="c x1 y56 w1a h2"><div class="t m0 x2 hb y57 ff4 fs0 fc0 sc0 ls0 ws4">conexi<span class="blank _2"> </span>ón <span class="blank _0"></span>con el medio externo<span class="blank"> </span><span class="ff1">(don<span class="blank _2"> </span>de las cé<span class="blank _0"></span>lulas una vez que logran cierta madure<span class="blank _0"></span>z </span></div></div><div class="c x1 y58 w1a hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">abandonan la medula ósea y se van a la circulación sanguínea).</div></div><div class="c x1 y59 w1b h1f"><div class="t m0 x2 h5 y5a ff2 fs1 fc0 sc0 ls0 ws4">TIPOS DE CÉLULAS MADRE.</div></div><div class="c x1 y5b w14 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Totipotente<span class="blank _0"></span>s.<span class="blank _1"> </span>Tienen la capacidad de generar<span class="blank _0"></span> todo. Se encuentran en embriones. Dan origen </div></div><div class="c x1 y5c w14 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">a un individu<span class="blank _2"> </span>o. Existen <span class="blank _0"></span>de 1 a 3 días después de<span class="blank _0"></span> la fecundación. Se pueden diferenciar a </div></div><div class="c x1 y5d w14 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">células tronca<span class="blank _0"></span>les embrionarias y se agrupan en células madre:</div></div><div class="c x3 y5e w4 h8"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">Pluripotent<span class="blank _0"></span>es:<span class="blank"> </span>Dan lugar a todos los tejidos del <span class="blank _0"></span>cuerpo. Dan or<span class="blank _0"></span>igen a células madre:</div></div><div class="c x4 y5f w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y60 w1c h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Multipotentes:<span class="blank"> </span>Van a irse especificando para cada te<span class="blank _0"></span>jido. Se puede dirigi<span class="blank _2"> </span>r <span class="blank _0"></span>solamente a </div></div><div class="c x3 y61 w1c h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">generar<span class="blank _0"></span> <span class="blank _2"> </span>células del corazón o del sistema nervioso, <span class="blank _0"></span>de acuerdo al destino que tenga </div></div><div class="c x3 y62 w1c h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">esta célula. DESTIN<span class="blank _2"> </span>O CELU<span class="blank _0"></span>LAR. Y estas CMM se van a diferenciar a celular madre<span class="blank _0"></span>:</div></div><div class="c x4 y63 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y64 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Unipotentes:<span class="blank"> </span>Las que van a diferenciarse ya a un tipo ce<span class="blank _0"></span>lular. Por ejemplo: células </div></div><div class="c x3 y65 w4 h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">mesenquimales (dan lugar al tejido adiposo, hueso, músculos), <span class="blank _0"></span>células tronca<span class="blank _0"></span>les </div></div><div class="c x3 y66 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">hematopoyét<span class="blank _0"></span>icas <span class="blank _2"> </span>(células sanguíneas), células tr<span class="blank _0"></span>oncales neuronales (neuronas y </div></div><div class="c x3 y67 w4 hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">células gliales). </div></div><div class="c x4 y68 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y69 w1d h1a"><div class="t m0 x2 h5 y6a ff2 fs1 fc0 sc0 ls0 ws4"><span class="fc2 sc0">C</span><span class="fc2 sc0">é</span><span class="fc2 sc0">lu</span><span class="fc2 sc0">la</span><span class="fc2 sc0"> </span><span class="fc2 sc0">Ma</span><span class="fc2 sc0">d</span><span class="blank _0"></span><span class="fc2 sc0">re </span><span class="fc2 sc0">He</span><span class="fc2 sc0">ma</span><span class="fc2 sc0">t</span><span class="fc2 sc0">o</span><span class="fc2 sc0">p</span><span class="fc2 sc0">o</span><span class="fc2 sc0">y</span><span class="fc2 sc0">é</span><span class="fc2 sc0">t</span><span class="fc2 sc0">ica.</span></div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>3</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y6b w11 h20" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg4.png"><div class="c x1 y30 w1d h16"><div class="t m0 x2 h17 y2 ff2 fs6 fc0 sc0 ls0 ws4">Célula Mad<span class="blank _0"></span>re Hematopoyética<span class="blank _0"></span>.</div></div><div class="c x1 y6c w1e h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Sería unipotente porque solo dará origen a las cé<span class="blank _0"></span>lulas sanguíneas. </div></div><div class="c x3 y6d w1f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Produce 4-5 x10^11 células sanguíneas por día.</div></div><div class="c x4 y6e w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y6f w20 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Son células multipotentes o unipotente<span class="blank _0"></span>s.</div></div><div class="c x4 y70 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y71 w4 ha"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Alto potencia<span class="blank _0"></span>l proli<span class="blank _2"> </span>ferativo. Necesitan e<span class="blank _0"></span>star en constante proliferación para poder </div></div><div class="c x3 y72 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">cubrir las dema<span class="blank _0"></span>ndas del <span class="blank _2"> </span>organismo.</div></div><div class="c x4 y73 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y74 w4 ha"><div class="t m0 x2 h3 y57 ff1 fs0 fc0 sc0 ls0 ws4">Alta capacidad de generac<span class="blank _0"></span>ión de nu<span class="blank _2"> </span>evas células madre<span class="blank _0"></span> idénticas. Se pueden </div></div><div class="c x3 y75 w4 h2"><div class="t m0 x2 h3 y76 ff1 fs0 fc0 sc0 ls0 ws4">autorre<span class="blank _0"></span>novar para s<span class="blank _2"> </span>eguir produciendo células y a su vez puede<span class="blank _0"></span>n producir nuevas </div></div><div class="c x3 y77 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">células maduras.</div></div><div class="c x4 y78 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y79 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">A medida que las CMHs maduran progresivamente van perdiendo su pote<span class="blank _0"></span>ncial de </div></div><div class="c x3 y7a w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">auto-renovar<span class="blank _0"></span>se <span class="blank _2"> </span>pero se vuelven mitótica<span class="blank _0"></span>mente más activas.</div></div><div class="c x4 y7b w5 h11"><div class="t m0 x2 h1e y7 ff3 fs2 fc0 sc0 ls0">-</div></div><div class="c x3 y7c w21 h2"><div class="t m0 x2 h3 y76 ff1 fs0 fc0 sc0 ls0 ws4">Se pueden autorre<span class="blank _0"></span>novarse <span class="blank _2"> </span>y diferenciarse.</div></div><div class="c x4 y7d w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y7e w22 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">¿PUEDE HABER REPROGRAMACIÓN?<span class="blank"> </span><span class="ff1 fs0">De una célula ya madura, sí.</span></div></div><div class="c x1 y7f w23 h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws4">Tarea: ¿De qué manera una célula marca su <span class="blank _0"></span>destino<span class="blank _2"> </span> <span class="blank _0"></span>a un linaje celul<span class="blank _2"> </span>ar?</div></div><div class="c x1 y80 w24 h4"><div class="t m0 x2 h5 y76 ff2 fs1 fc0 sc0 ls0 ws4">NICHO HEMAT<span class="blank _0"></span>OPOYÉTICO.</div></div><div class="c x1 y81 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Todas éstas células van a estar<span class="blank _0"></span> interact<span class="blank _0"></span>uando <span class="blank _2"> </span>entre sí<span class="blank _2"> </span> <span class="blank _0"></span>para poder brindarle a las cé<span class="blank _0"></span>lulas </div></div><div class="c x1 y82 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">hematopoyét<span class="blank _0"></span>icas <span class="blank _2"> </span>el nicho ideal para que é<span class="blank _0"></span>stas puedan crecer.</div></div><div class="c x3 y83 w4 h2"><div class="t m0 x2 h3 y76 ff1 fs0 fc0 sc0 ls0 ws4">Ambiente: Lugar en el cual va a estar dota<span class="blank _0"></span>do de citocinas, quimiocinas, component<span class="blank _0"></span>es </div></div><div class="c x3 y84 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">que van a estimular a la producción y a la ma<span class="blank _0"></span>duración. </div></div><div class="c x4 y85 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y86 w19 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Ejemplo: Células estroma<span class="blank _0"></span>les y las células endoteliales van a producir citoc<span class="blank _0"></span>inas que a su </div></div><div class="c x3 y87 w19 h2"><div class="t m0 x2 h3 y76 ff1 fs0 fc0 sc0 ls0 ws4">vez van a activar a las células hema<span class="blank _0"></span>topoyética<span class="blank _0"></span>s <span class="blank _2"> </span>para que éstas maduren. </div></div><div class="c x4 y88 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y89 w25 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">Para observar en lab<span class="blank _0"></span>oratorio:</div></div><div class="c x1 y8a w6 h2"><div class="t m0 xa hb y2 ff4 fs0 fc0 sc0 ls0 ws4">Iden<span class="blank _2"> </span>tificar <span class="blank _0"></span>las diferen<span class="blank _2"> </span>tes <span class="blank _3"></span>e<span class="blank _2"> </span>tapas de maduraci<span class="blank _2"> </span>ón <span class="blank _3"></span>de<span class="blank _2"> </span> una célul<span class="blank _2"> </span>a.</div></div><div class="c x1 y8b w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Todas las células de nuestro cuerpo van a expresar<span class="blank _0"></span> sobre su membrana una serie de </div></div><div class="c x1 y8c w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">proteínas que tiene<span class="blank _0"></span>n una fun<span class="blank _2"> </span>ción en particular y sirven para<span class="blank _0"></span> el análisis como <span class="blank _2"> </span>marcadores</div></div><div class="c x1 y8d w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">para poder identificarlas porque se expre<span class="blank _0"></span>san de manera diferencial. </div></div><div class="c x1 y8e w26 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Una célula madre hematopoyé<span class="blank _0"></span>tica s<span class="blank _2"> </span>e ca<span class="blank _0"></span>ract<span class="blank _0"></span>eriza <span class="blank _2"> </span>por este patrón de expresión:</div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>4</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 y8f w27 h21" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg5.png"><div class="c x3 y90 w28 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">CD110 (Trombopoyetina que le da capacidad de a<span class="blank _0"></span>utorrenova<span class="blank _0"></span>rse).</div></div><div class="c x4 y91 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y92 w29 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">CD117 (Fact<span class="blank _0"></span>or <span class="blank _2"> </span>de células madre que permite la proliferac<span class="blank _0"></span>ión y diferenciac<span class="blank _0"></span>ión).</div></div><div class="c x4 y93 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y94 w2a h8"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">CD105 (Fac<span class="blank _0"></span>tor TGF-<span class="blank _2"> </span><span class="ls2">B)</span></div></div><div class="c x4 y95 w5 h6"><div class="t m0 x2 h7 y96 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 y97 w2b h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws0">CD202b</div></div><div class="c x4 y98 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y99 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Está CMH tiene un patrón de expresión que nos pe<span class="blank _0"></span>rmite identificarlo en el laboratorio por </div></div><div class="c x1 y9a w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">técnica<span class="blank _0"></span>s como <span class="blank _2"> </span>la Citomet<span class="blank _0"></span>ría <span class="blank _2"> </span>de Flujo.</div></div><div class="c x1 y9b w2c h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">MAPA<span class="blank _0"></span> <span class="blank _2"> </span>DE LA HEMATOPOYE<span class="blank _0"></span>SIS.</div></div><div class="c x1 y9c w6 h1f"><div class="t m0 x2 h17 y2 ff2 fs6 fc0 sc0 ls0 ws4">Mecanismos moleculares <span class="blank _0"></span>para<span class="blank _0"></span> que se lleve a cabo la<span class="blank _0"></span> generación y </div></div><div class="c x1 y9d w6 h22"><div class="t m0 x2 h17 y2 ff2 fs6 fc0 sc0 ls0 ws4">maduración d<span class="blank _0"></span>e las células mad<span class="blank _0"></span>re hematopoyéticas. </div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>5</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 y9e w2d h23" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg6.png"><div class="c x1 y9f w2e h24"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">Cómo se lleva a<span class="blank _0"></span> cabo la maduración y <span class="blank _0"></span>que factor<span class="blank _0"></span>es intervienen para<span class="blank _0"></span> ese destino.</div></div><div class="c x3 ya0 w2f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">En primer lugar hay un Progenitor Mieloide Común (CMP).<span class="blank"> </span>Tiene la capacidad de poder </div></div><div class="c x3 ya1 w2f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">diferenciarse hacia dos células que pueden dar<span class="blank _0"></span> origen a diferentes tipos celulares. Esa </div></div><div class="c x3 ya2 w2f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">diferenciación está dada por la expresión de a<span class="blank _0"></span>lgunos factores de transcripción y </div></div><div class="c x3 ya3 w2f hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">algunos genes. </div></div><div class="c x4 ya4 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 ya5 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Fact<span class="blank _0"></span>or <span class="blank _2"> </span>de transcripción: Molécula que va a a<span class="blank _0"></span>ctivar a la transcripción (proceso por el cual un </div></div><div class="c x1 ya6 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">gen se va a tra<span class="blank _0"></span>nscribir a AR<span class="blank _2"> </span>N mensajero, pa<span class="blank _0"></span>ra que a su vez ese RNA se traduzca en una </div></div><div class="c x1 ya7 w6 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws0">proteína).</div></div><div class="c x3 ya8 w4 h18"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Los genes PU.1 y GATA<span class="blank _2"> </span>-1 son fac<span class="blank _0"></span>tores de transcripción<span class="blank"> </span>que van a promover la </div></div><div class="c x3 ya9 w4 h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">expresión de ciertos genes para<span class="blank _0"></span> <span class="blank _2"> </span>la diferenciación y para<span class="blank _0"></span> dirigi<span class="blank _2"> </span>r <span class="blank _0"></span>el destino de cie<span class="blank _0"></span>rtos </div></div><div class="c x3 yaa w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">tipos celulares. Si se expre<span class="blank _0"></span>sa el factor PU.1, el GATA<span class="blank _2"> </span>-<span class="blank _2"> </span>1 se <span class="blank _0"></span>inactiva y se apaga, así </div></div><div class="c x3 yab w4 hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">también al revé<span class="blank _0"></span>s. Es<span class="blank _2"> </span> decir, la expresión de <span class="blank _0"></span>un factor de transcripción inhibe la </div></div><div class="c x3 yac w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">expresión de otro.</div></div><div class="c x4 yad w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yae w4 h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">Si tene<span class="blank _0"></span>mos la <span class="blank _2"> </span>expresión de <span class="ff4 ws0">PU.1</span>,<span class="blank _2"> </span> el CMP<span class="blank"> </span>se <span class="blank _0"></span>va a dirigi<span class="blank _2"> </span>r <span class="blank _0"></span>hacia un progenitor de </div></div><div class="c x3 yaf w4 h2"><div class="t m0 x2 hb y76 ff1 fs0 fc0 sc0 ls0 ws4">monocitos y granulocitos (<span class="ff4 ls4 ws7">GMP</span>). Si se expresa el factor <span class="ff4 ws0">GATA-1</span>, se va a dirigir este </div></div><div class="c x3 yb0 w4 h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">CMP<span class="blank"> </span>hacia un progenitor de eritroc<span class="blank _0"></span>itos y megacariocitos (<span class="blank _2"> </span><span class="ff4 ws0">MEP</span><span class="ls1">).</span></div></div><div class="c x4 yb1 w5 h6"><div class="t m0 x2 h7 y96 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 yb2 w30 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Clave: Genes, rece<span class="blank _0"></span>ptores y en el medio.</div></div><div class="c x3 yb3 w2f h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">En el <span class="ff4 ws8">MEP<span class="blank"> </span></span>(Progenitor de Eritrocitos y Megacariocit<span class="blank _0"></span>os) tenemos l<span class="blank _2"> </span>a expre<span class="blank _0"></span>sión de dos </div></div><div class="c x3 yb4 w2f h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">factore<span class="blank _0"></span>s de transcripción: <span class="blank _2"> </span><span class="ff4">EKLF y Fli<span class="blank _2"> </span></span>. S<span class="blank _0"></span>i se expresa EKLF, no se expresa Fli, y así al revé<span class="blank _0"></span>s. </div></div><div class="c x3 yb5 w2f h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">Si se expresa <span class="ff4 ws9">EKLF<span class="blank"> </span></span>vamos a tener una difere<span class="blank _0"></span>nciación del progenitor de eritrocitos y </div></div><div class="c x3 yb6 w2f hc"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">megacar<span class="blank _0"></span>iocitos MEP hacia la maduración de células sanguíneas roja<span class="blank _0"></span>s (<span class="blank _5"> </span><span class="ff4 ws0">eritr<span class="blank _2"> </span>ocito<span class="blank _2"> </span>s</span>). Si <span class="blank _3"></span>se </div></div><div class="c x3 yb7 w2f h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">expresa <span class="ff4">Fli, </span>el MEP se dirige hacia la maduración de<span class="blank _0"></span> la línea para formar </div></div><div class="c x3 yb8 w2f h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws0">megacario<span class="blank _2"> </span>citos<span class="blank _2"> </span><span class="ff1 ls5 ws4">. <span class="blank _3"></span><span class="ls0">EN<span class="blank _2"> </span> TODOS LOS<span class="blank _0"></span> CASOS <span class="blank _2"> </span><span class="ff4">SIEMPRE VA A ESTAR EXPRESADO GA<span class="blank _0"></span>TA-<span class="ls6">1.</span></span></span></span></div></div><div class="c x4 yb9 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yba w31 h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls3 ws4">En <span class="ff4 ls4 wsa">GMP<span class="blank"> </span></span><span class="ls0">expresa: <span class="ff4">Gfi-1 y PU.1</span>. Si se expresa <span class="ff4 ws0">Gfi-1</span>, el GMP se va a difere<span class="blank _0"></span>nciar a </span></div></div><div class="c x3 ybb w31 h2"><div class="t m0 x2 hb y76 ff4 fs0 fc0 sc0 ls0 wsb">granul<span class="blank _2"> </span>ocitos.<span class="blank"> </span><span class="ff1 ws4">Si <span class="blank _2"> </span>se expresa únicamente </span><span class="ws0">PU.1<span class="ff1 ws4">, se va a diferenciar hacia los <span class="ff4">mono<span class="blank _2"> </span>citos <span class="blank _0"></span>y </span></span></span></div></div><div class="c x3 ybc w31 h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls0 ws4">macrófagos. SIEMPRE VA A ESTAR EXPRESADO PU.1<span class="ff1">.</span></div></div><div class="c x4 ybd w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>6</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 ybe w32 h25" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg7.png"><div class="c x1 ybf w33 h2"><div class="t m0 x2 hb y2 ff1 fs0 fc0 sc0 ls0 ws4">Para<span class="blank _0"></span> <span class="blank _2"> </span>el caso de los Progenitore<span class="blank _0"></span>s <span class="blank _2"> </span>Linfoi<span class="blank _2"> </span>des <span class="blank _0"></span>Comunes (<span class="ff4 ws0">CLP</span>). La célula va a expresar diferentes </div></div><div class="c x1 yc0 w33 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">factore<span class="blank _0"></span>s de transcripción para que <span class="blank _2"> </span>se pueda difere<span class="blank _0"></span>ncias hacia uno o hacia otro.</div></div><div class="c x3 yc1 w34 h8"><div class="t m0 x2 h26 y2 ff1 fs2 fc0 sc0 ls0 ws4">Fact<span class="blank _0"></span>ores i<span class="blank _2"> </span>mportant<span class="blank _0"></span>es: <span class="ff4">Ikaros y PU.1</span><span class="ls7">. </span></div></div><div class="c x4 yc2 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yc3 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Fact<span class="blank _0"></span>or <span class="blank _2"> </span>importante para poder diferenciar de linfocitos <span class="blank _0"></span>B y T: <span class="blank _2"> </span>Notch.<span class="blank"> </span>(Notch 1 y Notch </div></div><div class="c x3 yc4 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls6 ws4">2. <span class="ls0">Notch 2 va a dar origen a linfocitos B<span class="blank"> </span>y Notch 1 va a dar origen a los linfocitos <span class="blank _0"></span>T<span class="blank _2"> </span>.</span></div></div><div class="c x4 yc5 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yc6 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Si se dirige la CLP<span class="blank _0"></span> <span class="blank _2"> </span>a los linfocitos B, se <span class="blank _0"></span>van a expresar una serie de fac<span class="blank _0"></span>tores de </div></div><div class="c x3 yc7 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">transcripción específicos de los linfocitos B <span class="blank _0"></span>como: <span class="blank _2"> </span>E2A, EBF, Pax-5, Bcl11a, Evi9.</div></div><div class="c x4 yc8 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 yc9 w35 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws2">RESUMEN:</div></div><div class="c x1 yca w36 h4"><div class="t m0 x2 h5 y76 ff2 fs1 fc0 sc0 ls0 ws4">Líneas de generación de la<span class="blank _0"></span>s células sanguíneas. </div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>7</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 ycb w11 h27" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg8.png"><div class="c x3 ycc w2f h18"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">¿Podemos encontra<span class="blank _0"></span>r de <span class="blank _2"> </span>manera natural reticulocitos<span class="blank"> </span>en la sangre? Cuando hay baja de </div></div><div class="c x3 ycd w2f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">eritroc<span class="blank _0"></span>itos a ni<span class="blank _2"> </span>vel circulator<span class="blank _0"></span>io, la medula ósea intenta compensar esa deficiencia y </div></div><div class="c x3 yce w2f h8"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">comienza a producir de manera ace<span class="blank _0"></span>lerada el proceso de eritropoyesis y se le escapan </div></div><div class="c x3 ycf w2f hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">varios reticulocitos a la circulac<span class="blank _0"></span>ión.</div></div><div class="c x4 yd0 w5 h6"><div class="t m0 x2 h7 y96 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yd1 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">¿Los reticulocitos<span class="blank"> </span>pueden transportar<span class="blank _0"></span> <span class="blank _2"> </span>el oxígeno? Sí, pero no tan eficiente<span class="blank _0"></span> como el </div></div><div class="c x3 yd2 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws0">eritroc<span class="blank _0"></span>ito.</div></div><div class="c x4 yd3 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yd4 w37 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Hormona importante<span class="blank _0"></span>: <span class="blank _2"> </span>Eri<span class="blank _2"> </span>tropoyet<span class="blank _0"></span>ina. Producida por los riñones.</div></div><div class="c x4 yd5 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 yd6 w38 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws2">MEGACARIOCIT<span class="blank _0"></span>OS</div></div><div class="c x3 yd7 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Los megacar<span class="blank _0"></span>iocitos<span class="blank _1"> </span>van a estar en la medula ósea por lo genera<span class="blank _0"></span>l en condiciones </div></div><div class="c x3 yd8 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">normales y posteriormente las plaqueta<span class="blank _0"></span>s se liberan y pasan a circulación sanguínea. </div></div><div class="c x4 yd9 w5 h11"><div class="t m0 x2 h1e y7 ff3 fs2 fc0 sc0 ls0">-</div></div><div class="c x3 yda w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Los megacar<span class="blank _0"></span>iocitos<span class="blank _1"> </span>expresan el receptor c-mpl<span class="blank"> </span>va a producir que la célula se siga </div></div><div class="c x3 ydb w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">madurando, también con la acción de interle<span class="blank _0"></span>ucinas como la <span class="blank _2"> </span><span class="ls5 wsc">IL</span>-3, IL-6 e IL-<span class="ls6">11.</span></div></div><div class="c x4 ydc w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 ydd w39 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws4">LÍNEA MIELOIDE</div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>8</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x9 yde w3a h28" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bg9.png"><div class="c x3 ydf w3b h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Histiocito tisular: Se<span class="blank _0"></span> encuentra en los<span class="blank _2"> </span> t<span class="blank _0"></span>ejidos.</div></div><div class="c x4 ye0 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 ye1 w3c h2"><div class="t m0 x2 hb y2 ff4 fs0 fc0 sc0 ls8 wsd">IL<span class="ls0 wse">-3<span class="blank"> </span><span class="ff1 ws4">Tiene papel importa<span class="blank _0"></span>nte en l<span class="blank _2"> </span>a mayoría <span class="blank _0"></span>de los procesos hematopoyét<span class="blank _0"></span>icos.</span></span></div></div><div class="c x4 ye2 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 x6 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>9</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y4a w3d h29" alt="" src="https://files.passeidireto.com/bdab00ce-6f21-47be-acc9-ca6f40be6a1b/bga.png"><div class="c x1 ye3 w3e h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Generac<span class="blank _0"></span>ión de l<span class="blank _2"> </span>os linfocitos. </div></div><div class="c x1 ye4 w3f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Los linfocitos B y T expre<span class="blank _0"></span>san un <span class="blank _2"> </span>recept<span class="blank _0"></span>or único carac<span class="blank _0"></span>terístico <span class="blank _2"> </span>que les va a permitir identificar<span class="blank _0"></span> </div></div><div class="c x1 ye5 w3f h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">antígenos de manera<span class="blank _0"></span> <span class="blank _2"> </span>específica.</div></div><div class="c x3 ye6 w40 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Médula ósea = Linfocitos B. Timo = Linfocitos <span class="blank _0"></span>T.</div></div><div class="c x4 ye7 w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 ye8 w41 h8"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">Medula ósea, difere<span class="blank _0"></span>ntes eta<span class="blank _0"></span>pas de maduración.<span class="blank"> </span>Célula madre hema<span class="blank _0"></span>topoyét<span class="blank _0"></span>ica que s<span class="blank _2"> </span>e </div></div><div class="c x3 ye9 w41 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">va a difere<span class="blank _0"></span>nciar en un progenitor<span class="blank _0"></span> linfoi<span class="blank _2"> </span>de <span class="blank _0"></span>común y este<span class="blank _0"></span> "decidió" ir al li<span class="blank _2"> </span>naje de los </div></div><div class="c x3 yea w41 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">linfocitos b.<span class="blank"> </span>Se empieza <span class="blank _0"></span>a diferenciar en et<span class="blank _0"></span>apas Pro-B, pro B te<span class="blank _0"></span>mprana, pro-B tardía, </div></div><div class="c x3 yeb w41 hc"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">pre-B, linfocito B inmaduro que<span class="blank _0"></span> poster<span class="blank _0"></span>iormente<span class="blank _0"></span> <span class="blank _2"> </span>va aba<span class="blank _0"></span>ndonar l<span class="blank _2"> </span>a me<span class="blank _0"></span>dula y se dirigirá </div></div><div class="c x3 yec w41 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws4">hacia tej<span class="blank _0"></span>ido li<span class="blank _2"> </span>nfoide <span class="blank _0"></span>como los ganglios<span class="blank _2"> </span>. <span class="blank _0"></span>Terminan su madura<span class="blank _0"></span>ción en órganos linfoides </div></div><div class="c x3 yed w41 h2"><div class="t m0 x2 h9 y2 ff1 fs2 fc0 sc0 ls0 ws1">periféricos.</div></div><div class="c x4 yee w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yef w42 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Si el progenitor linfoide común "decide" difere<span class="blank _0"></span>nciarse hacia los <span class="blank _2"> </span>li<span class="blank _2"> </span>nfocitos T.<span class="blank"> </span>Desde que<span class="blank _0"></span> </div></div><div class="c x3 yf0 w42 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">es un progenitor linfoi<span class="blank _2"> </span>de <span class="blank _0"></span>común, va a aba<span class="blank _0"></span>ndonar la medula y se va a establece<span class="blank _0"></span>r en <span class="blank _2"> </span>el </div></div><div class="c x3 yf1 w42 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">timo.<span class="blank"> </span>En el tipo pasa por diferentes etapas de<span class="blank _0"></span> maduración hasta llegar a los diferentes </div></div><div class="c x3 yf2 w42 hc"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">tipos de células T que existen.</div></div><div class="c x4 yf3 w5 h11"><div class="t m0 x2 h1e y7 ff3 fs2 fc0 sc0 ls0">-</div></div><div class="c x3 yf4 w4 h2"><div class="t m0 x2 h3 y76 ff1 fs0 fc0 sc0 ls0 ws4">Cuando la célula se destina hacia linfocito <span class="blank _0"></span>T. Directa<span class="blank _0"></span>mente <span class="blank _2"> </span>del progenitor linfoide </div></div><div class="c x3 yf5 w4 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">común se diferencia a célula NK. Por algún fact<span class="blank _0"></span>or <span class="blank _2"> </span>o medio, se ac<span class="blank _0"></span>tivan genes que la </div></div><div class="c x3 yf6 w4 h2"><div class="t m0 x2 h3 y22 ff1 fs0 fc0 sc0 ls0 ws4">dirigen hacia células NK.</div></div><div class="c x4 yf7 w5 h11"><div class="t m0 x2 h1e y7 ff3 fs2 fc0 sc0 ls0">-</div></div><div class="c x1 yf8 w43 h4"><div class="t m0 x2 h5 y2 ff2 fs1 fc0 sc0 ls0 ws2">LINFOPOYESIS.</div></div><div class="c x3 yf9 w44 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls0 ws4">Va a tener origen en la medula ósea (Linfocitos B).<span class="blank"> </span>O en el Timo (Linfocitos T).</div></div><div class="c x4 yfa w5 h6"><div class="t m0 x2 h7 y7 ff3 fs0 fc0 sc0 ls0">-</div></div><div class="c x3 yfb w2f hd"><div class="t m0 x2 hb yfc ff4 fs0 fc0 sc0 ls0 ws4"><span class="fc2 sc0">Ó</span><span class="fc2 sc0">r</span><span class="fc2 sc0">ga</span><span class="fc2 sc0">n</span><span class="fc2 sc0">o</span><span class="fc2 sc0"> </span><span class="fc2 sc0">L</span><span class="fc2 sc0">i</span><span class="fc2 sc0">n</span><span class="fc2 sc0">f</span><span class="fc2 sc0">o</span><span class="fc2 sc0">i</span><span class="blank _2"> </span><span class="fc2 sc0">d</span><span class="fc2 sc0">e</span><span class="fc2 sc0">:</span><span class="blank _4"> </span><span class="ff1"><span class="fc2 sc0">V</span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">s</span><span class="fc2 sc0">e</span><span class="fc2 sc0">r</span><span class="fc2 sc0"> </span><span class="fc2 sc0">e</span><span class="fc2 sc0">s</span><span class="fc2 sc0">e</span><span class="fc2 sc0"> </span><span class="fc2 sc0">s</span><span class="fc2 sc0">i</span><span class="fc2 sc0">t</span><span class="fc2 sc0">i</span><span class="fc2 sc0">o </span><span class="fc2 sc0">a</span><span class="fc2 sc0">na</span><span class="fc2 sc0">t</span><span class="fc2 sc0">ómi</span><span class="fc2 sc0">c</span><span class="fc2 sc0">o </span><span class="fc2 sc0">don</span><span class="fc2 sc0">de</span><span class="fc2 sc0"> </span><span class="fc2 sc0">s</span><span class="fc2 sc0">e</span><span class="fc2 sc0"> </span><span class="fc2 sc0">va</span><span class="fc2 sc0"> </span><span class="fc2 sc0">a</span><span class="blank _0"></span><span class="fc2 sc0"> </span><span class="fc2 sc0">l</span><span class="fc2 sc0">l</span><span class="fc2 sc0">e</span><span class="fc2 sc0">va</span><span class="fc2 sc0">r</span><span class="fc2 sc0"> </span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">c</span><span class="fc2 sc0">a</span><span class="fc2 sc0">bo </span><span class="fc2 sc0">l</span><span class="fc2 sc0">a</span><span class="fc2 sc0"> </span><span class="fc2 sc0">ge</span><span class="fc2 sc0">ne</span><span class="fc2 sc0">r</span><span class="fc2 sc0">a</span><span class="fc2 sc0">c</span><span class="fc2 sc0">i</span><span class="fc2 sc0">ón </span></span></div></div><div class="c x4 yfd w5 h2a"><div class="t m0 x2 h7 y49 ff3 fs0 fc0 sc0 ls0"><span class="fc2 sc0">-</span></div></div><div class="c x1 y2d w10 h13"><div class="t m0 x2 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div><div class="c x5 y2d w0 h13"><div class="t m0 xb h14 y2e ff5 fs5 fc0 sc0 ls0 ws4">INMUNOLOG<span class="blank _0"></span>ÍA <span class="blank _2"> </span>B_ pági<span class="blank _0"></span>n<span class="blank _0"></span>a <span class="blank _2"> </span>10</div></div><div class="c x7 y2d w10 h13"><div class="t m0 x8 h14 y2e ff5 fs5 fc0 sc0 ls0 ws4"> </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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