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Reimpressão oficial do UpToDate www.uptodate.com © 2024 UpToDate, Inc. e/ou suas afiliadas. Todos os direitos reservados. Depressão unipolar em adultos: Epidemiologia INTRODUÇÃO A depressão é um importante problema de saúde pública associado ao aumento da incapacidade funcional e da mortalidade. Nos Estados Unidos, em 2010, as consequências económicas anuais estimadas da depressão unipolar major, incluindo custos médicos directos e custos no local de trabalho, ultrapassaram os 200 mil milhões de dólares [ 1 ]. Este tópico revisa a epidemiologia da depressão unipolar em adultos. As características clínicas, curso da doença, avaliação, diagnóstico e tratamento da depressão são discutidos separadamente. DEFINIÇÕES DE DEPRESSÃO O termo “depressão” pode ser usado de diversas maneiras, o que pode ser confuso; depressão pode se referir a um [ 2,3 ]: ® �����: Ranga Krishnan, MD ������ �� �����: Peter P Roy-Byrne, MD �������� ��������: Sara Swenson, médica, David Salomão, MD Todos os tópicos são atualizados à medida que novas evidências são disponibilizadas e nosso processo de revisão por pares é concluído. Revisão da literatura atualizada até: fevereiro de 2024. Última atualização deste tópico: 09 de janeiro de 2024. (Consulte "Depressão unipolar em adultos: características clínicas" .)● (Veja "Depressão unipolar em adultos: curso da doença" .)● (Veja "Depressão unipolar em adultos: avaliação e diagnóstico" .)● (Consulte "Depressão unipolar maior em adultos: escolha do tratamento inicial" .)● (Consulte "Depressão unipolar em adultos: escolha do tratamento para depressão resistente" .) ● https://www.uptodate.com/ https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/1 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/2,3 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/contributors https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/contributors https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/contributors https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/contributors https://www.uptodate.com/home/editorial-policy https://www.uptodate.com/home/editorial-policy https://www.uptodate.com/contents/unipolar-depression-in-adults-clinical-features?search=depress%C3%A3o&topicRef=1722&source=see_link https://www.uptodate.com/contents/unipolar-depression-in-adults-course-of-illness?search=depress%C3%A3o&topicRef=1722&source=see_link https://www.uptodate.com/contents/unipolar-depression-in-adults-assessment-and-diagnosis?search=depress%C3%A3o&topicRef=1722&source=see_link https://www.uptodate.com/contents/unipolar-major-depression-in-adults-choosing-initial-treatment?search=depress%C3%A3o&topicRef=1722&source=see_link https://www.uptodate.com/contents/unipolar-depression-in-adults-choosing-treatment-for-resistant-depression?search=depress%C3%A3o&topicRef=1722&source=see_link https://www.uptodate.com/contents/unipolar-depression-in-adults-choosing-treatment-for-resistant-depression?search=depress%C3%A3o&topicRef=1722&source=see_link PREVALÊNCIA A depressão unipolar é altamente prevalente em adultos em todo o mundo. Prevalence in general medical disorders — Depressive syndromes are highly prevalent across the world in outpatients with general medical disorders and appear to be more common in these outpatients than the general population (see 'Prevalence in general population' below). A meta-analysis identified 83 cross-sectional studies from five continents that included outpatients with general medical disorders (total n >41,000); studies of patients whose depression predated their general medical disorders were excluded [4]. The pooled point prevalence of depression was 27 percent. However, heterogeneity across studies was very large, and the prevalence in different specialties varied from approximately 15 to 50 percent. A subgroup of eight studies compared outpatients (n >3000) with controls who did not have general medical disorders (n >3000), and found that the pooled point prevalence was three times greater in outpatients (18 versus 6 percent). Prevalence in general population Worldwide — Depression is highly prevalent in the general population of adults throughout the world. Nationally or regionally representative surveys in 21 countries estimate that the 12- month prevalence of unipolar major depression across all countries is 5 percent [5]. In addition, the lifetime prevalence of unipolar major depression plus persistent depressive disorder (dysthymia), according to surveys in 14 countries, is approximately 12 percent [6]. Among the 14 countries [6]: Estado de humor, indicado por sentimentos de tristeza, desespero, ansiedade, vazio, desânimo ou desesperança; não ter sentimentos; ou parecendo choroso. O humor deprimido (disfórico) pode ser normal ou um sintoma de uma síndrome psicopatológica ou de um distúrbio médico geral. ● Síndrome, que é uma constelação de sintomas e sinais que podem incluir humor deprimido. As síndromes depressivas normalmente encontradas incluem depressão maior, depressão menor ou distimia (transtorno depressivo persistente). ● Transtorno mental que identifica uma condição clínica distinta. Por exemplo, a síndrome de depressão maior pode ocorrer em vários transtornos, como depressão maior unipolar (também chamada de “transtorno depressivo maior”), transtorno bipolar, esquizofrenia, transtorno depressivo induzido por substância/medicamento e transtorno depressivo devido a outro ( geral) condição médica. ● The prevalence of unipolar major depression plus persistent depressive disorder in developed countries (United States and Europe) is approximately 18 percent. ● https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/4 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/5 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/6 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/6 This twofold difference between developed and resource-limited countries may reflect true variation in the determinants of depression due to cultural or genetic factors, sample selection biases, and problems with the cross-cultural portability of diagnostic criteria [7,8]. United States — Depression is highly prevalent in the general population of the United States. A nationally representative survey of adults in the United States found that the 12- month prevalence of unipolar major depression was 10 percent, and the lifetime prevalence was 21 percent [9]. The prevalence of persistent depressive disorder (dysthymia) appears to be less than that of unipolar major depression. As an example, a nationally representative survey found that the lifetime prevalence of persistent depressive disorder was 3 percent [10]. Other countries — Depressive syndromes are highly prevalent in the general population of many countries beyond the United States. Nationally or regionally representative community surveys in different countries found that the 12-month prevalence of unipolar major depression was as follows [5]: In resource-limited countries (eg, People’s Republic of China, Mexico, and Brazil), the estimated lifetime prevalence is 9 percent. ● Argentina – 4 percent● Belgium – 5 percent● Brazil – 10 percent● Bulgaria – 3 percent● China (People’s Republic) – 2 percent● Colombia – 5 percent● France – 6 percent● Germany – 3 percent● Iraq – 4 percent● Israel – 6 percent● Italy – 3 percent● Japan – 2 percent● Lebanon – 5 percent● Mexico – 4 percent● Netherlands – 5 percent● Nigeria – 1 percent● Peru – 3 percent● Portugal – 7 percent● Romania – 2 percent● Spain – 4 percent● https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/7,8 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/10https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/5 AGE OF ONSET Multiple studies consistently indicate that in the general population of the United States, the average age of onset for unipolar major depression and for persistent depressive disorder (dysthymia) is approximately 30 years [10,11]. As an example, a nationally representative survey of adults found that onset of the first lifetime episode of major depression occurs at age 29 years [9]. DEMOGRAPHIC RISK FACTORS Several sociodemographic factors are associated with an increased risk for unipolar depression. Age — Within the general population of the United States, major depression is more common in younger adults than older adults. A nationally representative survey found that the 12- month prevalence of unipolar major depression was greater in younger age groups than adults aged 65 years or more (11 to 13 versus 5 percent) [9]. In addition, the lifetime prevalence was greater in younger age groups (20 to 23 versus 14 percent). Similarly, a subsequent survey found that clinically significant depressive symptoms were more common among younger adults [12]. The prevalence of depression in older adults declines as they age. A community survey of adults aged 55 years and older in the United States found that the 12-month prevalence of major depression decreased significantly with increasing age [13]. However, certain groups of older adults have higher rates of depression compared with older adults in general. The prevalence in older primary care patients is comparable to that of younger patients [14,15]. Depression is even more common in older adults with a greater burden of medical illness, including residents of assisted living or skilled nursing facilities, recipients of home health care, and patients suffering from a wide range of acute and chronic medical conditions [16-19]. Income — In the general population of the United States, the prevalence of major depression is greater among individuals with less income. A 2013 nationally representative survey in the United States found that the 12-month prevalence of unipolar major depression in lower household income categories is greater compared with the highest family income category ($70,000 or more; 10 to 14 versus 8 percent) [9]. However, the differences in the lifetime prevalence of major depression between lower categories and the highest category are less pronounced (20 to 23 and 20 percent). https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/10,11 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/12 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/13 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/14,15 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/16-19 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 Marital status — A nationally representative survey in the United States found that the prevalence of unipolar major depression is highest in adults who are divorced, separated, or widowed [9]: Race/ethnicity — A nationally representative survey in the United States found that the prevalence of unipolar major depression among different racial groups is highest in Native Americans and lowest in Asians/Pacific Islanders [9]: Sex — Within the general population of the United States, as well as other countries, the prevalence of depressive syndromes is approximately two times greater in females than males [20,21]: Twelve-month prevalence● Married/cohabitating – 8 percent• Never married – 13 percent• Divorced, separated, or widowed – 14 percent• Lifetime prevalence● Married/cohabitating – 19 percent• Never married – 21 percent• Divorced, separated, or widowed – 26 percent• Twelve-month prevalence● Asian/Pacific Islander – 7 percent• Black – 9 percent• Hispanic – 10 percent• Native American – 16 percent• White – 11 percent• Lifetime prevalence● Asian/Pacific Islander – 12 percent• Black – 15 percent• Hispanic – 16 percent• Native American – 28 percent• White – 23 percent• A nationally representative survey in the United States found that the 12-month prevalence of unipolar major depression in females and males is 13 and 7 percent [9]. In addition, the lifetime prevalence in females and males is 26 and 15 percent. ● https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/20,21 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 The prevalence rates for females and males may differ because the etiology of depression in each sex is different [23]. SUMMARY AND RECOMMENDATIONS Use of UpToDate is subject to the Terms of Use. Surveys of community-dwelling adults in 15 countries (including the United States) found that the lifetime prevalence of major depression and persistent depressive disorder (dysthymia) were each 1.9 times higher in females compared with men [22]. ● Population prevalence – The estimated 12-month prevalence of unipolar major depression in the worldwide general population is 5 percent. In addition, the lifetime prevalence of unipolar major depression plus persistent depressive disorder (dysthymia) is approximately 12 percent. The estimated 12-month prevalence of unipolar major depression in specific countries apart from the United States ranges from 1 to 10 percent. (See 'Worldwide' above and 'Other countries' above.) ● Among the general population of adults in the United States, the estimated 12-month prevalence of unipolar major depression is 10 percent, and the lifetime prevalence is 21 percent. (See 'United States' above.) Prevalence in outpatient clinical settings – Across the world, the point prevalence of depression in outpatients with general medical disorders is roughly 25 percent and depressive syndromes appear to be more common in outpatient clinical settings than the community (general population). (See 'Prevalence in general medical disorders' above.) ● Age of onset – The average age of onset for unipolar major depression and for persistent depressive disorder (dysthymia) in the general population of the United States is approximately 30 years. (See 'Age of onset' above.) ● Demographic risk factors – Within the general population of the United States, major depression is more common in younger adults, individuals with less income, and is highest in adults who are divorced, separated, or widowed. In the United States, the prevalence of unipolar major depression among different racial groups is highest in Native Americans and lowest in Asians/Pacific Islanders. ● Worldwide, the prevalence of depressive syndromes in the general population is approximately two times greater in females than males. (See 'Age' above and 'Income' above and 'Marital status' above and 'Race/ethnicity' above and 'Sex' above.) https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/23 https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/22 REFERENCES 1. Greenberg PE, Fournier AA, Sisitsky T, et al. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry 2015; 76:155. 2. American Psychiatric Association. 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Int J Psychiatry Med 1998; 28:421. https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/1 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/1 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/4 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/4 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/5 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/5 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/6 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/6 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/7 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/7 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/8 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/8 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/8 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/9 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/10 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/10 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/10 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/11 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/11 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/11 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/12 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/12 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/12 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/13 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/13 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/13 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/14 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/14 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/15 https://www.uptodate.com/contents/unipolar-depression-in-adults-epidemiology/abstract/15 16. Lyness JM, Niculescu A, Tu X, et al. The relationship of medical comorbidity and depression in older, primary care patients. Psychosomatics 2006; 47:435. 17. Lebowitz BD, Pearson JL, Schneider LS, et al. Diagnosis and treatment of depression in late life. Consensus statement update. JAMA 1997; 278:1186. 18. Charney DS, Reynolds CF 3rd, Lewis L, et al. Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Arch Gen Psychiatry 2003; 60:664. 19. Katz IR. On the Inseparability of Mental and Physical Health in Aged Persons: Lessons From Depression and Medical Comorbidity. Am J Geriatr Psychiatry 1996; 4:1. 20. Weinberger AH, Gbedemah M, Martinez AM, et al. Trends in depression prevalence in the USA from 2005 to 2015: widening disparities in vulnerable groups. Psychol Med 2018; 48:1308. 21. Pedersen CB, Mors O, Bertelsen A, et al. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry 2014; 71:573. 22. Seedat S, Scott KM, Angermeyer MC, et al. Associações transnacionais entre gênero e transtornos mentais nas Pesquisas Mundiais de Saúde Mental da Organização Mundial da Saúde. Psiquiatria Arch Gen 2009; 66:785. 23. Kendler KS, Gardner CO. Diferenças sexuais nos caminhos para a depressão maior: um estudo de pares de gêmeos do sexo oposto. Am J Psiquiatria 2014; 171:426. Tópico 1722 Versão 49.0 Divulgações do Colaborador Ranga Krishnan, MD Não há relacionamento(s) financeiro(s) relevante(s) com empresas inelegíveis para serem divulgadas. Peter P Roy-Byrne, MD Nenhuma relação financeira relevante com empresas inelegíveis para divulgar. Sara Swenson, MD Não há relacionamento(s) financeiro(s) relevante(s) com empresas inelegíveis para divulgar. David Solomon, MD Não há relacionamento(s) financeiro(s) relevante(s) com empresas inelegíveis para divulgar. As divulgações dos colaboradores são revisadas quanto a conflitos de interesse pelo grupo editorial. Quando encontrados, estes são abordados através de um processo de revisão multinível e através de requisitos para referências a serem fornecidas para apoiar o conteúdo. O conteúdo referenciado adequadamente é exigido de todos os autores e deve estar em conformidade com os padrões de evidência do UpToDate. 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