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DENTOALVEOLAR SURGERY *Gradu Pelotas, RS yReside Pelotas, Pe zProfes of Pelotas, xProfes University Conflic relevant fi What Are the Parameters for Reoperation in Mandibular Third Molars Submitted to Coronectomy? A Systematic Review Bh�arbara Marinho Barcellos, BDent,* Bibiana Dalsasso Velasques, BDent,y Lucas Borin Moura, PhD,z and Cristina Braga Xavier, PhDx Purpose: Coronectomy is an alternative technique to conventional lower third molar removal that aims to decrease inferior alveolar nerve impairment. The purpose of this studywas to identify factors associated with reoperation after mandibular third molar coronectomy. Materials and Methods: This systematic review sought scientific articles in the MEDLINE (PubMed), Scopus (Elsevier), and Cochrane Library databases. Studies that evaluated reoperation after coronectomy and reported a minimum follow-up of 6 months were included. The Preferred Reporting Items for System- atic Reviews and Meta-Analyses (PRISMA) quality assessment of the included articles was performed, and the following data were analyzed: demographic characteristics, reason for reoperation, and time from coronectomy to reoperation. The data were subjected to descriptive analysis. Results: The initial search yielded 362 studies and 15 were included in the final review. In total, 1,664 patients and 2,062 teeth underwent coronectomy. Most patients were women (60.58%). The follow-up period for reoperation ranged from 6 months to 10 years and the mean time until the second procedure was 10.4 months (quartile 1, 3; quartile 3, 8.5). Only 105 teeth (5.1%) were reoperated on. The main rea- sons for reoperation were root exposure (53.33%), infection (10.47%), pain (9.52%), and enamel residual (9.52%). In the PRISMA quality evaluation, only 1 article presented a low risk of bias. Conclusions: Reoperation after mandibular third molar coronectomy was low (cases, �5%); the main reasons for reoperation were residual root exposure and symptomatology. Owing to the possibility of late exposure or symptomatology, a follow-up longer than 6 months is recommended until root exposure or the end of the migration process. � 2019 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 77:1108-1115, 2019 Surgical removal of impacted mandibular third mo- lars that present dental roots in close proximity to the inferior alveolar nerve (IAN) can result in its injury. Imaging modalities such as panoramic radiography and cone-beam computed tomography are important diagnostic tools in these cases.1 ate Program in Dentistry, Federal University of Pelotas, , Brazil. nt in Maxillofacial Surgery Program, Federal University of lotas, RS, Brazil. sor of Oral Surgery, Dentistry Course, Catholic University Pelotas, RS, Brazil. sor of Oral and Maxillofacial Surgery Department, Federal of Pelotas, Pelotas, RS, Brazil. t of Interest Disclosures: None of the authors have any nancial relationship(s) with a commercial interest. 1108 Radiographic signs that indicate close proximity be- tween the dental roots and the IAN are deviation of the canal, narrowing of the canal, a periapical radio- lucent area, narrowing of roots, darkening of roots, curving of roots, and loss of the lamina dura of the canal.2,3 Address correspondence and reprint requests to Dr Xavier: Department of Oral and Maxillofacial Surgery, Federal University of Pelotas, Brasil Rua Goncalves Chaves, 457, 96015-560 Pelotas, RS, Brazil; e-mail: cristinabxavier@gmail.com Received July 13 2018 Accepted January 7 2019 � 2019 American Association of Oral and Maxillofacial Surgeons 0278-2391/19/30016-3 https://doi.org/10.1016/j.joms.2019.01.013 mailto:cristinabxavier@gmail.com https://doi.org/10.1016/j.joms.2019.01.013 http://crossmark.crossref.org/dialog/?doi=10.1016/j.joms.2019.01.013&domain=pdf BARCELLOS ET AL 1109 The coronectomy technique is an alternative to the conventional removal of impacted teeth and aims to decrease the risk of IAN damage. This technique con- sists of removal of the dental crown and intentional retention of the residual roots inside the alveolar bone.4,5 Migration of residual roots is a possible outcome of coronectomy. This occurs in 14 to 81% of cases, with an average migration of 2 to 4 mm at 2 years toward the oral cavity.4-9 Root migration is intense in the first 6 postoperative months,10 is sub- stantial in the first 2 postoperative years, and then sta- bilizes between the second and third years.1 If a continuous migration occurs, it can result in root exposure in the oral cavity up to 7 years after the pro- cedure and can cause inflammation or localized infection.4,10,11 The purpose of this study was to verify the inci- dence and patterns that indicate reoperation after mandibular third molar coronectomy. The authors hy- pothesized that the main reasons for reoperation would be related to clinical symptomatology and not to radiographic changes such as root migration. The specific aims of the study were to verify the incidence rate of reoperation after mandibular third molar coro- nectomy and to define clinical and radiographic pa- rameters indicating the stage for reoperation. Materials and Methods To address the research purpose, the authors designed and implemented a systematic review modeled after the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) state- ment12 and the Cochrane Collaboration’s recommen- dations for systematic reviews.13 In accordance with the PRISMA statement for systematic reviews, the following focus question of research was established: what are the clinical and Table 1. SEARCH STRATEGY USED FOR EACH DATABASE Database S MEDLINE (coronectomy) AND third molar; (coronectom reoperation; (coronectomy) AND root migra SCOPUS (TITLE-ABS-KEY (coronectomy) AND TITLE-AB AND TITLE-ABS-KEY (complications); TITLE (reoperation); TITLE-ABS-KEY (coronectomy Cochrane Library ‘‘coronectomy’’ in Title, Abstract, Keywords an Reviews’; ‘‘coronectomy’’ in Title, Abstract, K in Cochrane Reviews’; ‘‘coronectomy’’ in Tit Abstract, Keywords in Trials’; ‘‘coronectomy Title, Abstract, Keywords in Other Reviews’ Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Max radiographic parameters for reoperation of mandib- ular third molars after coronectomy? STUDY DESIGN This study is a systematic review and the samplewas composed of all publications on the topic of third molar coronectomy without time limitation until June 2018. The electronic search was performed in the following databases: MEDLINE (PubMed), SCOPUS (Elsevier), and the Cochrane Library. The final search was performed on June 13, 2018. The search terms initially used were coronectomy, third molar, complications, reoperation, and root migration. From the keywords, detailed search strate- gies were developed for each database (Table 1). A manual search also was conducted based on the refer- ence lists of the included studies and previ- ous reviews. VARIABLES The following variables were analyzed from the studies: � Number of patients and gender distribution � Mean age of patients � Number of teeth subjected to coronectomy � Follow-up � Number of reoperations � Reason for reoperation � Time until reoperation � Follow-up after reoperation DATA COLLECTION METHODS For the initial selection, 2 independent reviewers (B.M.B. and B.D.V.) analyzed the title or abstract of all searched studies, which were subjected to the earch Strategy y) AND complications; (coronectomy) AND tion S-KEY (third AND molar)); TITLE-ABS-KEY (coronectomy) -ABS-KEY (coronectomy) AND TITLE-ABS-KEY ) AND TITLE-ABS-KEY (root AND migration) d ‘‘third molar’’ in Title, Abstract, Keywords in Cochrane eywords and ‘‘complications’’ in Title, Abstract, Keywords le, Abstract, Keywords and ‘‘root migration’’ in Title, ’’ in Title, Abstract, Keywords and ‘‘reoperation’’ in illofac Surg 2019. 1110 REOPERATION AFTER THIRDMOLAR CORONECTOMY inclusion and exclusion criteria established before the beginning of the study. To be included in the study sample, publications had to adopt the following inclu- sion criteria: studies in English, clinical trials (prospec- tive, retrospective, or randomized), studies that reported a minimum postoperative period of 6 months, and studies that evaluated the outcomes that required reoperations. There was no time restric- tion for the date of publication. Systematic reviews, meta-analyses, narrative reviews, case reports, and case series were excluded from the analyses. After determining the studies included in the systematic review, the 2 trained researchers collected and tabulated all data using Excel 2016 (Microsoft, Redmond, WA). The results were imported to Endnote (Thomson Reuters, Toronto, ON, Canada) and, after duplicate removal, the titles and abstracts were evalu- ated by the 2 independent reviewers. In case of diver- gence, 2 expert researchers (C.B.X. and L.B.M.) were consulted. After the initial selection, the 4 examiners read the full texts of the studies and, using the same selection criteria, determined the final inclusion of studies in the systematic review. Disagreements between reviewers were resolved through further discussion. DATA ANALYSES The following data were extracted: year, author, gender and number of patients, mean age (years), number of teeth subjected to coronectomy, follow- up, number of reoperations, reason for reoperation, time until reoperation, and follow-up after reopera- tion. The extracted data were subjected to descriptive analysis. The quality assessment evaluation was performed using the PRISMA method. The following criteria were used to classify the potential risk of bias in each study: random population selection, definition of inclusion and exclusion criteria, report of loss to follow-up, validated measurements, and statistical analysis. Studies that met all these criteria were classi- fied as having a low risk of bias; those that did not meet 1 of these criteria were classified as having a moderate risk of bias; and those that did not meet at least 2 of these criteria were classified as having a high risk of bias. Results The electronic search was conducted on June 13, 2018, and 362 studies were retrieved. After exclusion of 254 duplicates, 108 studies remained. Titles and abstracts were read, and 39 studies were selected for full-text reading and evaluation according to the inclu- sion and exclusion criteria defined earlier. Twenty-four studies were excluded because they did not fulfill at least 1 selection criterion. Therefore, 15 studies were included in this systematic review. Figure 1 presents the flowchart of the systematic review process. For quality evaluation, only 1 article presented a low risk of bias,14 5 studies showed a medium risk of bias,9,15-18 and 9 studies showed a high risk of bias2-4,7,19-23 (Table 2). In total, 1,664 patients underwent coronectomy procedures, most of whom were women (68.58%; Table 3). Three studies did not document the gender of the included patients4,7,20 and only 1 did not report the total number of patients.20 Of 2,062 teeth subjected to coronectomy, 105 teeth (5.1%) underwent reoperation. Most reported causes for reoperation were residual root exposure owing to migration (n = 56 [53.33%]), infection (n = 11 [10.47%]), pain (n = 10 [9.52%]), and residual enamel (n = 10 [9.52%]). Only 1 article mentioned the need for residual root removal because of orthognathic sur- gery.3 Two studies did not specify the reasons for the reoperations2,14; the other studies reported reoperation because of root migration without exposure or the presence of symptomatology. The follow-up after the procedure ranged from 6months to 10 years. However, only 1 article reported follow-up after reoperation.15 Using the data from 7 studies,2,4,7,9,18,20,23 the mean time until reoperation was calculated as 10.4 months (quartile 1, 3; quartile 3, 8.5; Fig 2). Three studies did not report time until reoperation.16,17,19 Figure 3 presents the time until re- operation according to the data available in each study; most reoperations occurred within the first 2 years of follow-up. Discussion The purpose of this study was to verify the patterns related to reoperation after mandibular third molar coronectomy. The authors’ hypothesis was that clin- ical features would predict the reoperation. Moreover, the specific goals were to determine the percentage of cases reoperated on after coronectomy and to define the clinical and radiographic parameters indicating the stage for reoperation. As result, it was possible to observe a small rate of reoperation after mandibular third molar coronectomy. The usual reasons were root exposure with or without symptomatology. Also, considerable reoperation was performed after 6 months of follow-up (mean, 10.4 months), which in- dicates a longer follow-up is necessary. The results of this study confirm in part the hypoth- esis that the clinical characteristics would predict the reoperation. The clinical parameters predominated, although residual enamel (a radiographic feature) also predicted reoperation. The main reasons for a sec- ond procedure were related to symptomatology, root FIGURE 1. Systematic review process showing numbers of included and excluded articles. Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Maxillofac Surg 2019. BARCELLOS ET AL 1111 exposure, and presence of residual enamel. Based on the reoperation rate of 5.1%, the second procedure, despite being a technical disadvantage, does not repre- sent a failure, and coronectomy remains a safe alterna- tive for the extraction of mandibular third molars closely connected to the mandibular canal. Table 2. RISK OF BIAS ASSESSED USING THE PREFERRED REP ANALYSES QUALITY STATEMENT Study Year Random Selection in Population Definition of Inclusion and Exclusion Criteria O’Riordan7 2004 No No Pogrel et al4 2004 No Yes Hatano et al2 2009 No Yes Leung et al9 2009 Yes Yes Cilasun et al20 2011 No Yes Goto et al15 2012 No Yes Leung and Cheung14 2012 Yes Yes Monaco et al23 2012 No Yes Agbaje et al19 2015 No Yes Frenkel et al21 2015 No No Kohara et al16 2015 No Yes Monaco et al17 2015 No Yes Kouwenberg et al22 2016 No No Leung and Cheung3 2016 Yes Yes Vignudelli et al18 2017 No Yes Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Max Leaving the roots in situ after a coronectomy pro- cedure can have consequences, such as the need for reoperation. There was a discussion in the literature about the concept of success and failure in coronec- tomy. Some investigators considered coronectomy a failure when a second procedure was needed.5,9 ORTING ITEMS FOR SYSTEMATIC REVIEWS AND META- Report of Loss to Follow-Up Valid Measurements Statistical Analysis Estimated Potential Risk of Bias Yes No No High No No No High No No Yes High No Yes Yes Medium No No No High Yes Yes Yes Medium Yes Yes Yes Low Yes No Yes High No No Yes High Yes Yes Yes High Yes Yes Yes Medium Yes Yes Yes Medium Yes Yes Yes High Yes No No High Yes Yes Yes Medium illofac Surg 2019. Table 3. DATA EXTRACTED FROM STUDIES INCLUDED IN THE FINAL REVIEW Study (Year) Patients, N Gender, n Age (yr), Mean Teeth, n Follow-Up Reoperation, n (%) Reason for Reoperation, n Time to Reoperation, Mean Follow-Up (Reoperation) O’Riordan7 (2004) 52 — — 52 10 yr 3 (6.0) Infection, 1; periodontal disease, 1; pain and edema, 1 34.1 mo — Pogrel et al4 (2004) 41 — — 50 22 mo 3 (5.8) Incomplete healing, 2; root exposure, 1 6 mo — Hatano et al2 (2009) 102 M, 27; F, 75 32.3 (SD, 10.3) 102 12 mo 5 (4.9) Infection, 4; not specified, 1 3 mo — Leung et al9 (2009) 171 M, 70; F, 101 27.2 171 10.6 mo 1 (1.7) Root exposure, 1 9 mo — Cilasun, et al20 (2011) — — 27.1 88 16.3 mo (6-29 mo) 1 (1.1) Pain, 1 10 days — Goto etal15 (2012) 101 M, 37*; F, 79 —y 116 12 mo 9 (7.8) Root exposure, 8; pain, 1 1-12 mo 12 mo Leung and Cheung14 (2012) 98 M, 35; F, 63 27.6 135 36 mo 4 (3.0) Not specified, 3; root exposure, 1 9-24 mo — Monaco et al24 (2012) 37 M, 17; F, 20 31.0 43 12 mo 1 (2.3) Pain, 1 10 mo — Agbaje et al19 (2015) 64 M, 28; F, 36 — (range, 15- 55) 96 12 mo 9 (9.4) Root exposure, 5; infection, 4 — — Frenkel et al21 (2015) 173 M, 110*; F, 75 27.6 (range, 17- 65) 185 6-12 mo 10 (5.4) Enamel retention, 6; pain, 2; root exposure, 1; root moved during procedure, 1 1-12 mo — Kohara et al16 (2015) 92 M, 29; F, 63 33.8 111 36 mo 10 (9.0) Palpable root, 7; root exposure, 2; pain, 1 3-24 mo — Monaco et al17 (2015) 94 M, 37; F, 57 28.9, (SD, 8.9) 116 36 mo 8 (6.9) Root exposure, 4; enamel retention, 3; hyperplasia distal to second molar, 1 — — Kouwenberg et al22 (2016) 151 M, 59; F, 92 30.8 151 6 mo 17 (11.3) Root exposure, 17 — — Leung and Cheung3 (2016) 458 M, 172; F, 286 28.9 612 60 mo 20 (3.3) Root exposure, 14; infection, 2; pain, 2; enamel retention, 1; orthognathic procedure, 1 2 wk to 60 mo — Vignudelli et al18 (2017) 30 M, 9; F, 21 28.0 (SD, 7.0; range, 17-56) 34 9 mo 4 (11.8) Root exposure, 2; pain, 1; palpable root, 1 8 mo — Abbreviations: F, female; M, male; SD, standard deviation. * The study reported gender according to the number of teeth subjected to coronectomy. y In this study, 48 patients (41.4%) were no older than 29 years, 42 (36.2%) were 30 to 39 years old, and 26 (22.4%) were at least 40 years old. Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Maxillofac Surg 2019. 1 1 1 2 R E O P E R A T IO N A F T E R T H IR D M O L A R C O R O N E C T O M Y FIGURE 2. Boxplot of mean time until reoperation. Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Maxillofac Surg 2019. BARCELLOS ET AL 1113 However, others judged that the potential of IAN injury during a second operation is decreased when the residual roots migrate from the mandibular canal.8,15 Leung and Cheung14 observed that none of the reoperations to remove an exposed root resulted in an IAN neurosensory disturbance. Thus, this could be considered a success because the main objective was achieved. Cilasun et al20 reported a 95.5% success rate for coronectomy cases, and Frenkel et al21 achieved success in 97.0% of cases in their study. Despite the success, there is a lack of data in the liter- ature to define which cases require reoperation. The literature showed intimate correlations among age, gender, tooth morphology, and root migra- tion.3,11,21 After coronectomy, 30% of roots migrate from the mandibular canal,4 moving up to 4 mm dur- ing the first 2 years.8 Furthermore, Kohara et al16 found that 82.2% of cases showed no root migration between the second and third postoperative years. Moreover, Frenkel et al21 and Goto et al15 reported that patients older than 40 years exhibited decreased root migration compared with patients in their 20s. In addition, studies that compared the association of patient’s age and gender with root migration rates observed that root migration was markedly higher in younger and female patients.14,16,21,23 Most coronectomy cases reported in the literature involved root migration, although most roots remained asymptomatic and covered by bone.15,16,23 Root migration is considered a reason for reopera- tion only when it leads to exposure of residual roots in the oral cavity.23-25 In this systematic review, the main reason for reoperation was exposure of roots in the oral cavity. Root exposure was reported in most included studies as a reason to reoperate.3,9,14-19,21,22 In the literature, the rates of root exposure were low (1.3 to 2.3% of cases).3,26 In contrast, root exposure occurred in more than half the reoperations in this study. It is established that residual roots stop migrating after 2 years; therefore, some investigators believe there is almost no chance of late complications 2 to 3 years after coronectomy.14,16,20 However, O’Riordan7 reported a case in which root exposure occurred after 7 years, requiring removal. These data indicate that a longer follow-up is essential for patients after coronectomy, although a follow-up of only 6 months is recommended.10 Most researchers agree with the need for root removal after exposure, although it has been stated that exposed roots can remain if the patient can main- tain a clean area.15,22 Also, Leung and Cheung3 re- ported a case in which the residual roots erupted after 2 years, and the exposed edges were trimmed without root removal. The authors believe that resid- ual roots should be removed to avoid inflammatory complications, such as periodontal disease or even infection. Also, the authors support the logical thinking that, as the residual roots move closer to the surface, they will be farther from the IAN and the risk of nerve injury will be decreased compared with the original situation. Therefore, even when it is necessary to remove the exposed roots, coronec- tomy remains successful. Many studies evaluated the association between postoperative events and the anatomic characteristics of mandibular third molars.2,4,15 Renton et al5 re- ported that teeth with vertical impaction and narrow roots have a higher risk of undergoing a second pro- cedure. In addition, Leung and Cheung14 observed that distoangular impaction carried a higher risk of root eruption compared with other patterns of impac- tion. Furthermore, Goto et al15 stated that migration of conical roots is considerably greater than that of enlarged roots, with greater chances of erupting in the oral cavity. The comparison of dental characteristics, such as the position, angulation, and pattern of impaction and root morphology, with the possible outcomes could bring benefits, such as prediction of root expo- sure and its prognosis. Renton et al5 found that female patients who had conical roots presented a higher risk of reoperation. In this review, the authors tried to extract data related to tooth characteristics. Although some investigators classified the third molars involved in the studies,2,3,9,14-16,18 it was not possible to collect FIGURE 3. Distribution of reoperation time (years) according to each study. Barcellos et al. Reoperation After Third Molar Coronectomy. J Oral Maxillofac Surg 2019. 1114 REOPERATION AFTER THIRD MOLAR CORONECTOMY quantitative data to define parameters that predict reoperation. Kouwenberg et al22 analyzed the out- comes of coronectomy of mandibular third molars with an increased risk of IAN damage on preoperative panoramic radiographs, but they could not identify any parameter that might predict reoperation. Howev- er, a recent study observed that the classification of Winter27 is intimately related to the root migration pattern after coronectomy in the first 6 months after the procedure. However, no statistically relevant dif- ferences were found after 6-month follow-up.28 Pain was a reason for reoperation in 10 cases (9.52%) in this review. Cilasun et al20 reported a pa- tient’s request for root removal because of pain on the 10th postoperative day. In another study, after 10 months of intermittent pain, a patient requested root removal.23 These data could lead one to reflect that if a patient presents persistent pain that is no longer considered normal owing to the minor oral sur- gery procedure, then pain is a reason to remove the roots. Immediate postoperative pain within the first week is generally expected by patients. Because it varies from days to years, the literature does not dictate how long reoperation should be postponed, and there is no standardized guide that indicates reop- eration after a certain duration of chronic pain after coronectomy. Infection was a reason for reoperation in 10.47% of cases.2,3,7,19 Another systematic review reported no relevant differences in postoperativeinfection rates between coronectomy and total extraction.26 Infection occurrence is difficult to predict because it is intimately correlated with physiopathologic re- sponses and oral hygiene. This complication has been treated by the removal of residual roots.29 Residual enamel had to be removed with a second procedure in only 5 cases in this review. Pogrel et al4 stated horizontal molars contraindicated a coronec- tomy because the dental sectioning could damage the IAN, and if not all enamel is removed, then a lack of bone healing and infection might occur. In the present review, only 2 studies reported reoperation for residual enamel.17,21 Therefore, immediate postoperative panoramic radiography is recommended to evaluate the procedure and diagnose any residual enamel. If it is identified, then the patient should undergo a second procedure to remove the enamel, optimize bone healing, and prevent infection.21 The reoperation rate was 5.1%, and the reasons for a second procedure were related to symptomatology, root exposure, and presence of residual enamel. None of the studies mentioned reoperation for only migration of the roots without any signs of exposure, pain, infection, or residual enamel. The limitation of this systematic review is the lack of studies with a low risk of bias and specified data. The rate of reopera- tion was mentioned but not completely explained, indicating the findings should be interpreted carefully and studied with more defined parameters. Ideally, studies should determine more accurately the right stage for reoperation using more objective criteria, such as the position and radicular morphology of BARCELLOS ET AL 1115 mandibular third molars. In addition, future studies should apply a longer follow-up to verify late outcomes. According to the analysis of these studies, it was possible to conclude that the reoperation rate is low and that, when it occurs, it is due to symptomatology, root exposure, or presence of residual enamel. Root migration is not indicative of reoperation as long as there is no exposure or symptomatology. Most reoper- ations were performed after 6 months, indicating that long-term follow-up should be applied. Reoperation, despite being a technical disadvantage, is not a failure, and coronectomy remains a safe alternative for the extraction of mandibular third molars closely con- nected to the mandibular canal. Therefore, future studies might focus on specific data correlating reoper- ation to preoperative clinical and radiographic features to define surgical predictability and longer follow-up evaluation to properly analyze the outcomes. References 1. Ghaeminia H, Gerlach NL, Hoppenreijs TJM, et al: Clinical rele- vance of cone beam computed tomography in mandibular third molar removal: A multicentre, randomised, controlled trial. J Craniomaxillofac Surg 43:2158, 2015 2. Hatano Y, Kurita K, Kuroiwa Y, et al: Clinical evaluations of cor- onectomy (intentional partial odontectomy) for mandibular third molars using dental computed tomography: A case- control study. J Oral Maxillofac Surg 67:1806, 2009 3. Leung YY, Cheung LK: Long-term morbidities of coronectomy on lower third molar. Oral Surg Oral Med Oral Pathol Oral Radiol 121:5, 2016 4. Pogrel MA, Lee JS, Muff DF: Coronectomy: A technique to pro- tect the inferior alveolar nerve. J Oral Maxillofac Surg 62:1447, 2004 5. Renton T, Hankins M, Sproate C, Mcgurk M: A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars. Br J Oral Maxillofac Surg 43:7, 2005 6. Freedman GL: Intentional partial odontectomy: Review of cases. J Oral Maxillofac Surg 55:524, 1997 7. O’Riordan BC: Coronectomy (intentional partial odontectomy of lower third molars). Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 98:274, 2004 8. Dolanmaz D, Yildirim G, Isik K, et al: A preferable technique for protecting the inferior alveolar nerve: coronectomy. J Oral Max- illofac Surg 67:1234, 2009 9. Leung YY, Cheung LK, Kong H: Safety of coronectomy versus excision of wisdom teeth: A randomized controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:821, 2009 10. Pogrel M: Partial odontectomy. Oral Maxillofac Surg Clin North Am 19:85, 2007 11. Patel V, Gleeson CF, Kwok J, Sproat C: Coronectomy practice. Pa- per 2: Complications and long term management. Br J Oral Max- illofac Surg 51:347, 2013 12. Liberati A, Altman DG, Tetzlaf JF, et al: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med 6:e1000100, 2009 13. Higgins JPT, Green S (eds): Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0; 2011. London, UK, The Cochrane Collaboration, 2011. Available at: http:// handbook.cochrane.org. Updated March 2011. Accessed December7, 2017 14. Leung YY, Cheung LK: Coronectomy of the lower third molar is safe within the first 3 years. J Oral Maxillofac Surg 70:1515, 2012 15. Goto S, Kurita K, Kuroiwa Y, et al: Clinical and dental computed tomographic evaluation 1 year after coronectomy. J Oral Maxil- lofac Surg 70:1023, 2012 16. Kohara K, Kurita K, Kuroiwa Y, et al: Usefulness of mandibular third molar coronectomy assessed through clinical evaluation over three years of follow-up. Int J Oral Maxillofac Surg 44: 259, 2015 17. Monaco G, De Santis G, Pulpito G, et al: What are the types and frequencies of complications associated with mandibular third molar coronectomy? A follow-up study. J Oral Maxillofac Surg 73:1246, 2015 18. Vignudelli E, Rosaria M, Gatto A, et al: The periodontal healing distally to the second mandibular molar after third molar’s coro- nectomy. J Oral Maxillofac Surg 75:21, 2017 19. Agbaje JO, Heijsters G, Salem AS, et al: Coronectomy of deeply impacted lower third molar: Incidence of outcomes and compli- cations after 1-year follow-up. J Oral Maxillofac Surg 6:e1, 2015 20. 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A Systematic Review Materials and Methods Study Design Variables Data Collection Methods Data Analyses Results Discussion References