Aula Imunidade Inata

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Imunidade Inata: 
Mecanismos Efetores 
Professora Patricia Pacheco 
Figure 2-1 
Imunidade Inata x Imunidade Adaptativa 
Figure 2-2 part 1 of 2 
Figure 2-2 part 2 of 2 
Figure 2-3 
Exemplo de Resposta à Infecção 
Figure 2-4 
Figure 2-5 part 1 of 2 
Figure 2-5 part 2 of 2 
Figure 2-6 
Fagocitose 
Adaptado de Curnutte et al, 2002 
Figure 2-8 part 1 of 2 
Figure 2-8 part 2 of 2 
Figure 2-9 
Figure 2-10 
Figure 2-11 
Figure 2-12 
TLR Ligands - Recognition 
PAMPS 
TLR Ligand Source 
TLR1/2 lipoarabinomanin mycobacteria 
TLR2±6 Zymosan Fungi 
TLR3 DS RNA Viruses 
TLR4 lipopolysaccharide 
Peptidoglycan 
RSV fusion protein 
Gr- bacteria 
Gr+ bacteria 
RSV 
TLR5 Flagellin Flagelated bacteria 
TLR6/2 Diacyl lipopeptides Mycoplasma 
TLR7 and 8 SS RNA 
Imidazoquinolones 
Viruses 
Synthetic 
TLR9 CpG Bacteria and DNA viruses 
TLR10 Unknown 
Figure 2-13 
TLR 
5/10/11 
TLR 2 TLR 1/6 TLR 4 
NF-κB binding motif 
NEMO 
IKK-β IKK-α 
NF-κB 
IRAK4 
TLR signal generation to NF-κB after ligation 
New gene 
transcription 
TLR 3 
Nucleus 
Cytoplasm 
MD2 CD14 
MyD88 
MyD88 
TLR 
7/8/9 Endosome 
MyD88 
MyD88 
TIRAP 
TIRAP 
TRIF 
RIP1 
IκB 
IκB 
p
TRAF6 
Cell membrane 
TLR 
5/10/11 
TLR 2 TLR 1/6 TLR 4 
MAPK 
IRAK4 
New gene 
transcription 
TLR 3 
Nucleus 
Cytoplasm 
MD2 CD14 
MyD88 
MyD88 
TLR 
7/8/9 Endosome 
MyD88 
MyD88 
TIRAP 
TIRAP 
TRIF 
TRAF6 
IRF5 
Cell membrane 
TLR induction of other transcription factors 
IRAK1/4 
TRAF6 
IRF7 
TRIF 
TRAM 
TBK1 
IRF3 AP-1 
Figure 2-15 
Figure 2-39 
Figure 2-41 part 1 of 2 
Figure 2-41 part 2 of 2 
Figure 2-45 
Figure 2-46 
Figure 2-47 
Figure 2-44 
Figure 2-42 
Figure 2-43 
(CD11a/CD18) 
E-Selectin Sialyl-Lewis-X 
Quimiotaxia de 
Neutrófilos 
Rolagem Adesão Emigração Transendotelial 
LAD- I LAD- II