<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg1.png"><div class="t m0 x1 h1 y1 ff1 fs0 fc0 sc0 ls0 ws0"> HEMA<span class="_0 blank"></span>T<span class="_1 blank"></span>OL<span class="_1 blank"></span>OGIA<span class="ff2"> </span></div><div class="t m0 x2 h2 y2 ff3 fs1 fc0 sc0 ls0 ws0">PROF<span class="_1 blank"></span>.: ROBSON <span class="_2 blank"></span>CARDIL<span class="_2 blank"></span>O AL<span class="_3 blank"></span>VES<span class="ff4"> </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg2.png"><div class="t m0 x3 h3 y3 ff5 fs2 fc0 sc0 ls0 ws0">HEMA<span class="_4 blank"></span>T<span class="_2 blank"></span>OLOGIA<span class="_4 blank"></span> <span class="_2 blank"></span>CL<span class="ff6 ws1">Í</span><span class="ws2">NICA</span><span class="ff2"> </span></div><div class="t m0 x4 h4 y4 ff2 fs3 fc0 sc0 ls0 ws0"> </div><div class="t m0 x4 h4 y5 ff2 fs3 fc0 sc0 ls0 ws0"> </div><div class="t m0 x4 h4 y6 ff2 fs3 fc0 sc0 ls0 ws0"> </div><div class="t m0 x4 h4 y7 ff2 fs3 fc0 sc0 ls0 ws0"> </div><div class="t m0 x4 h5 y8 ff2 fs4 fc0 sc0 ls0 ws0">1 <span class="ff7 ws3">\u2013</span> HEMA<span class="_1 blank"></span>T<span class="_2 blank"></span>OPOIESE </div><div class="t m0 x4 h6 y9 ff8 fs5 fc0 sc0 ls0 ws0">- ORIGEM <span class="_5 blank"> </span>GREGA<span class="_2 blank"></span> <span class="ff9 ls1">\u2013</span><span class="ls2"> </span><span class="ff9 ws4">\u201cHÂIAMA\u201d</span> <span class="_5 blank"> </span>= SANGUE<span class="ff2"> </span></div><div class="t m0 x4 h6 ya ff8 fs5 fc0 sc0 ls0 ws0"> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span><span class="ff9 ws4">\u201cPOIESIS\u201d</span> <span class="_5 blank"> </span>= CRIA<span class="_5 blank"> </span>R, PRODUZIR, F<span class="_1 blank"></span>A<span class="_5 blank"> </span>ZER<span class="ff2"> </span></div><div class="t m0 x4 h6 yb ff8 fs5 fc0 sc0 ls0 ws0"> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span> <span class="_5 blank"> </span><span class="ff9 ws4">\u201cPOIETES\u201d</span> <span class="_5 blank"> </span>= <span class="_2 blank"></span>AR<span class="_2 blank"></span>TES<span class="_5 blank"> </span>ÃO, POET<span class="_1 blank"></span>A<span class="ff2"> </span></div><div class="t m0 x4 h6 yc ff2 fs5 fc0 sc0 ls0 ws5">OBS<span class="ls3">.:</span><span class="ws0"> HEM<span class="_5 blank"> </span>A<span class="_1 blank"></span>TOPOIESE é a formação <span class="_5 blank"> </span><span class="ls1">do</span> sangue. </span></div><div class="t m0 x4 h6 yd ff2 fs5 fc0 sc0 ls0 ws0">Sangue <span class="_6 blank"> </span>é <span class="_6 blank"> </span>composto <span class="_6 blank"> </span><span class="ls1 ws6">por</span> uma <span class="_6 blank"> </span>parte <span class="_6 blank"> </span>líquida (plasma) <span class="_6 blank"> </span>e <span class="_6 blank"> </span>por <span class="_6 blank"> </span>uma parte <span class="_6 blank"> </span>celular<span class="_3 blank"></span>, </div><div class="t m0 x4 h7 ye ff2 fs6 fc0 sc0 ls0 ws0">contendo <span class="_7 blank"> </span>células <span class="_7 blank"> </span>nucleadas <span class="_7 blank"> </span>e <span class="_7 blank"> </span>anucleadas. <span class="_7 blank"> </span>São <span class="_7 blank"> </span><span class="lsa ws7">os</span> <span class="_7 blank"> </span>elementos <span class="_7 blank"> </span>figurados </div><div class="t m0 x4 h6 yf ff2 fs5 fc0 sc0 ls0 ws0">sanguíneos <span class="_5 blank"> </span>( hemác<span class="_5 blank"> </span>ias, <span class="_5 blank"> </span>leucócitos e <span class="_5 blank"> </span>plaquetas). <span class="_5 blank"> </span>A<span class="_2 blank"></span> medula óssea<span class="_5 blank"> </span> é o <span class="_5 blank"> </span>principal <span class="_5 blank"> </span>sítio </div><div class="t m0 x4 h6 y10 ff2 fs5 fc0 sc0 ls1 ws6">de<span class="ls0 ws0"> formação </span>do<span class="ls0 ws0"> <span class="_5 blank"> </span>sangue ( <span class="_5 blank"> </span>adulto). </span></div><div class="t m0 x4 h6 y11 ff2 fs5 fc0 sc0 ls0 ws0">O <span class="_8 blank"> </span>ritmo <span class="_8 blank"> </span><span class="ls1 ws6">de</span> <span class="_8 blank"> </span>produção <span class="_8 blank"> </span>está <span class="_8 blank"> </span>ajustado <span class="_8 blank"> </span><span class="ls1 ws6">as</span> <span class="_9 blank"> </span>necessidades <span class="_8 blank"> </span>reais <span class="_9 blank"> </span>e<span class="_5 blank"> </span> <span class="_9 blank"> </span>pod<span class="_5 blank"> </span>e <span class="_9 blank"> </span>variar<span class="_5 blank"> </span> <span class="_9 blank"> </span><span class="ls1 ws6">do<span class="_5 blank"> </span></span> <span class="_9 blank"> </span>zero<span class="_5 blank"> </span> </div><div class="t m0 x4 h6 y12 ff2 fs5 fc0 sc0 ls1 ws6">até<span class="ls0 ws0"> <span class="_5 blank"> </span>muitas <span class="_5 blank"> </span>vez<span class="_5 blank"> </span>es <span class="_5 blank"> </span>normal. <span class="_5 blank"> </span>A<span class="_2 blank"></span> produ<span class="_5 blank"> </span>ção <span class="_5 blank"> </span>celular <span class="_5 blank"> </span>sustentada,<span class="_5 blank"> </span> <span class="_5 blank"> </span><span class="ls1">depende<span class="ls4"> </span>da</span> <span class="_5 blank"> </span>presença <span class="_5 blank"> </span><span class="ls1 ws6">de</span> </span></div><div class="t m0 x4 h6 y13 ff7 fs5 fc0 sc0 ls0 ws5">\u201cPOOLS\u201d<span class="_5 blank"> </span><span class="ff2 ls5 ws0"> <span class="ls1 ws6">de</span><span class="ls0"> <span class="_9 blank"> </span>c<span class="_5 blank"> </span>élulas <span class="_8 blank"> </span>primordiais <span class="_8 blank"> </span>capazes <span class="_8 blank"> </span><span class="ls1">não<span class="ls6"> <span class="lsb ws8">só</span><span class="ls7"> </span></span>de</span> <span class="_9 blank"> </span>diferenciação<span class="_5 blank"> </span> <span class="_9 blank"> </span>como<span class="_5 blank"> </span> <span class="_8 blank"> </span>também </span></span></div><div class="t m0 x4 h6 y14 ff2 fs5 fc0 sc0 ls1 ws6">de<span class="ls0 ws0"> </span>auto<span class="ls0 ws0">-renovação ( <span class="_5 blank"> </span>UNIDADES FORMADORAS <span class="_5 blank"> </span><span class="lsc ws9">DE</span> COLONIAS </span><span class="ff7">\u2013</span><span class="ls0 ws0"> CFU <span class="_5 blank"> </span>). </span></div><div class="t m0 x4 h6 y15 ff2 fs5 fc0 sc0 ls0 ws0">O <span class="_a blank"> </span><span class="ls1 ws6">pool</span> <span class="_a blank"> </span>mais <span class="_a blank"> </span>primiti<span class="_5 blank"> </span>vo <span class="_a blank"> </span>consiste <span class="_a blank"> </span><span class="ls1">de</span> <span class="_a blank"> </span>células <span class="_a blank"> </span>pluripotenciais<span class="_5 blank"> </span> <span class="_a blank"> </span>com <span class="_a blank"> </span>capacidade <span class="_a blank"> </span><span class="ls1">de<span class="ls8"> </span><span class="ws6">auto</span></span>- </div><div class="t m0 x4 h6 y16 ff2 fs5 fc0 sc0 ls0 ws0">renovação <span class="_9 blank"> </span>contínua <span class="_9 blank"> </span>( <span class="_b blank"> </span>STEM <span class="_9 blank"> </span>CELLS). <span class="_b blank"> </span>O <span class="_9 blank"> </span><span class="ls1 ws6">pool</span> <span class="_b blank"> </span>mai<span class="_5 blank"> </span>s <span class="_b blank"> </span>m<span class="_5 blank"> </span>aduro <span class="_b blank"> </span>é <span class="_9 blank"> </span>formado <span class="_9 blank"> </span><span class="ls1 ws6">por</span> <span class="_b blank"> </span>células </div><div class="t m0 x4 h6 y17 ff2 fs5 fc0 sc0 ls0 ws0">unipotenciais <span class="_c blank"> </span>diferenciadas,<span class="_5 blank"> </span> <span class="_c blank"> </span>com <span class="_c blank"> </span>sua <span class="_c blank"> </span>maturação<span class="_5 blank"> </span> <span class="_c blank"> </span>restrita<span class="_5 blank"> </span> <span class="_c blank"> </span>a <span class="_c blank"> </span>uma <span class="_c blank"> </span>linhagem <span class="_c blank"> </span>celular </div><div class="t m0 x4 h6 y18 ff2 fs5 fc0 sc0 ls0 ws0">sem <span class="_a blank"> </span>capacidade <span class="_5 blank"> </span><span class="ls1">de<span class="ls9"> </span><span class="ws6">auto</span></span>-<span class="_5 blank"> </span>renovação, <span class="_a blank"> </span>isto <span class="_5 blank"> </span><span class="ls1 ws6">é,</span> <span class="_a blank"> </span>células <span class="_a blank"> </span>com <span class="_5 blank"> </span><span class="ls1 ws6">um<span class="_5 blank"> </span></span> <span class="_5 blank"> </span>nível<span class="_5 blank"> </span> <span class="_5 blank"> </span><span class="ls1">de</span> <span class="_a blank"> </span>diferenciação </div><div class="t m0 x4 h6 y19 ff2 fs5 fc0 sc0 lsd wsa">já<span class="ls0 ws0"> comprometido a uma <span class="_5 blank"> </span>determinada <span class="_5 blank"> </span>linhagem celular<span class="_2 blank"></span>. </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg3.png"></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg4.png"></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg5.png"><div class="t m0 x5 h8 y1a ff2 fs7 fc0 sc0 ls0 ws0">O <span class="_2 blank"></span>hematócrito é <span class="_2 blank"></span>a porcentagem <span class="_2 blank"></span>(%) do </div><div class="t m0 x5 h9 y1b ff2 fs8 fc0 sc0 ls0 ws0">volume <span class="_2 blank"></span>total de sangue que é <span class="_2 blank"></span>ocup<span class="_5 blank"> </span>ada pelas </div><div class="t m0 x5 h9 y1c ff2 fs8 fc0 sc0 ls0 ws0">células vermelhas <span class="_2 blank"></span>agrupa<span class="_5 blank"></span>das </div><div class="t m0 x5 h9 y1d ff2 fs8 fc0 sc0 ls0 ws0">do sangue. </div><div class="t m0 x5 h9 y1e ff2 fs8 fc0 sc0 ls0 ws0">Conteúdo de <span class="_2 blank"></span>hemog<span class="_5 blank"> </span>lobina (Hb) <span class="_2 blank"></span>dos </div><div class="t m0 x5 h8 y1f ff2 fs7 fc0 sc0 ls0 ws0">eritrócitos. <span class="_2 blank"></span>É medido <span class="_2 blank"></span>como o conteúdo <span class="_2 blank"></span>total de </div><div class="t m0 x5 h9 y20 ff2 fs8 fc0 sc0 ls0 ws0">hemoglobina<span class="_5 blank"></span> <span class="_2 blank"></span>do sangue (g <span class="_2 blank"></span>Hb/dL). </div><div class="t m0 x5 h9 y21 ff2 fs8 fc0 sc0 ls0 ws0">Contagem de <span class="_2 blank"></span>células vermelhas: em <span class="_2 blank"></span>milhões<span class="_5 blank"> </span> </div><div class="t m0 x5 h9 y22 ff2 fs8 fc0 sc0 ls0 ws0">de células por <span class="_2 blank"></span>microlitro. Uma <span class="_2 blank"></span>máquin<span class="_5 blank"> </span>a conta </div><div class="t m0 x5 h9 y23 ff2 fs8 fc0 sc0 ls0 ws0">as células <span class="_2 blank"></span>de acord<span class="_5 blank"> </span>o <span class="_2 blank"></span>com a quantidade de <span class="_2 blank"></span>luz </div><div class="t m0 x5 h8 y24 ff2 fs7 fc0 sc0 ls0 ws0">que passa <span class="_2 blank"></span>por elas. </div><div class="t m0 x5 h9 y25 ff2 fs8 fc0 sc0 ls0 ws0">A<span class="_1 blank"></span> morfologia das células <span class="_2 blank"></span>vermelha<span class="_5 blank"></span>s: <span class="_2 blank"></span>fornec<span class="_5 blank"></span>e </div><div class="t m0 x5 h9 y26 ff2 fs8 fc0 sc0 ls0 ws0">diagnóstico de <span class="_2 blank"></span>doen<span class="_5 blank"> </span>ças. </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg6.png"></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg7.png"><div class="t m0 x6 ha y27 ffa fs9 fc0 sc0 ls0 ws0">F<span class="_d blank"></span>A<span class="_e blank"></span>T<span class="_2 blank"></span>ORES <span class="_2 blank"></span>DA<span class="_1 blank"></span> ERITROPOESE </div><div class="t m0 x6 hb y28 ffa fsa fc0 sc0 ls0 ws0"> </div><div class="t m0 x6 hc y29 ffa fsb fc0 sc0 ls0 ws0"> </div><div class="t m0 x6 hd y2a ff2 fsb fc0 sc0 ls0 ws0">Os mais importantes <span class="_5 blank"></span>são:<span class="_5 blank"></span> </div><div class="t m0 x6 he y2b ff7 fsa fc0 sc0 ls0 wsb">\u2013<span class="ff2 ws0">Eritropoetina </span></div><div class="t m0 x6 hd y2c ff7 fsb fc0 sc0 ls0 wsc">\u2013<span class="ff2 ws0">V<span class="_f blank"></span>itamina B12 </span></div><div class="t m0 x6 hd y2d ff7 fsb fc0 sc0 ls0 wsc">\u2013<span class="ff2 ws0"> Folatos </span></div><div class="t m0 x6 hd y2e ff7 fsb fc0 sc0 ls0 wsc">\u2013<span class="ff2 ws0"> Ferro </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg8.png"><div class="t m0 x7 hf y2f ff2 fsc fc1 sc0 ls0 ws0">FERRO </div><div class="t m0 x8 h10 y30 ff2 fs9 fc1 sc0 ls0 ws0">V<span class="_f blank"></span>itamina B<span class="fsd lse wsd v1">12</span> </div><div class="t m0 x8 h10 y31 ff2 fs9 fc1 sc0 ls0 ws0">Ácido Fólico </div><div class="t m0 x9 h11 y32 ff2 fsd fc1 sc0 ls0 ws0">Hemoglobinização </div><div class="t m0 xa h11 y33 ff2 fsd fc1 sc0 ls0 ws0">Maturação Celula<span class="_2 blank"></span>r </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bg9.png"><div class="t m0 xb h12 y34 ffb fse fc2 sc0 ls0 ws0">TRANSFERRINA <span class="_2 blank"></span>E FERRITINA </div><div class="t m0 xc h9 y35 ff2 fs8 fc0 sc0 ls0 ws0">A<span class="_1 blank"></span> <span class="_2 blank"></span>TRANSFERRINA<span class="_3 blank"></span> é uma </div><div class="t m0 xc h8 y36 ff2 fs7 fc0 sc0 ls0 ws0">glicoproteína <span class="_f blank"></span>sintetizada </div><div class="t m0 xc h9 y37 ff2 fs8 fc0 sc0 ls0 ws0">principalmente <span class="_2 blank"></span>no fígado <span class="_2 blank"></span>e é a </div><div class="t m0 xc h9 y38 ff2 fs8 fc0 sc0 ls0 ws0">principal proteína </div><div class="t m0 xc h13 y39 ff2 fs8 fc0 sc0 ls0 ws0">plasmática <span class="_2 blank"></span><span class="ffa wse">transportadora<span class="_5 blank"> </span><span class="ff2 ws0"> <span class="_f blank"></span>de ferro. </span></span></div><div class="t m0 xd h8 y3a ff2 fs7 fc0 sc0 ls0 ws0">A<span class="_1 blank"></span> FERRITINA<span class="_1 blank"></span> é uma <span class="_2 blank"></span>glicoproteína <span class="_2 blank"></span>de </div><div class="t m0 xd h9 y3b ff2 fs8 fc0 sc0 ls0 ws0">alto peso <span class="_2 blank"></span>molecular<span class="_3 blank"></span>, </div><div class="t m0 xd h13 y3c ff2 fs8 fc0 sc0 lsf wsf">que<span class="ls0 ws0"> <span class="_2 blank"></span><span class="ffa wse">armazena<span class="ff2 ws0"> 20% a <span class="_2 blank"></span>25% do ferro <span class="_f blank"></span>do </span></span></span></div><div class="t m0 xd h9 y3d ff2 fs8 fc0 sc0 ls0 ws0">organismo. <span class="_2 blank"></span>Sua concentração <span class="_f blank"></span>séric<span class="_5 blank"> </span>a </div><div class="t m0 xd h9 y3e ff2 fs8 fc0 sc0 ls0 ws0">correlaciona-se <span class="_2 blank"></span>com os <span class="_2 blank"></span>estoques<span class="_5 blank"> </span> <span class="_2 blank"></span>de </div><div class="t m0 xd h8 y3f ff2 fs7 fc0 sc0 ls0 ws0">ferro <span class="_f blank"></span>total do organismo. </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/8507eb73-bcb3-455d-b85a-b8733ec3d517/bga.png"><div class="t m0 xe h14 y40 ffb fsf fc2 sc0 ls0 ws0">REGULAÇÃO </div><div class="t m0 xf h15 y41 ffb fs10 fc0 sc0 ls0 ws0"> <span class="_2 blank"></span> REGULAÇÃO<span class="_5 blank"></span> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div>
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