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What are the characteristics of the main reversers of neuromuscular blockers (BNM)? I - Neostigmine is widely used as the main reverser of neuromu...

What are the characteristics of the main reversers of neuromuscular blockers (BNM)?

I - Neostigmine is widely used as the main reverser of neuromuscular blockers, but it is not free of side effects such as sialorrhea, bradycardia, nausea, vomiting, and even intestinal perforation.
II - Sugammadex is a cyclodextrin that has high affinity for rocuronium and can reverse neuromuscular blockade without the chance of residual blockade.
III - Calabadion is a member of the cucurbit(n)uril group that forms complexes with molecules of varying sizes, and it can encapsulate both aminoesteroids and benzylisoquinolines.
IV - CW002-cysteine is a promising benzylisoquinoline neuromuscular blocker that has already been approved by the FDA.
V - The encapsulation technique is a growing field of research, and cyclodextrins function as a container for a variety of neutral and cationic species with high selectivity and affinity.
a) I, II, III, IV and V are correct.
b) I, II, III and V are correct.
c) II, III, IV and V are correct.
d) I, II and III are correct.
e) Only II and III are correct.

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A alternativa correta é a letra d) I, II e III estão corretas. Neostigmina é amplamente utilizada como o principal reversor dos bloqueadores neuromusculares, mas pode causar efeitos colaterais como sialorreia, bradicardia, náuseas, vômitos e até perfuração intestinal. Sugamadex é uma ciclodextrina que tem alta afinidade pelo rocurônio e pode reverter o bloqueio neuromuscular sem o risco de bloqueio residual. Calabadion é um membro do grupo das cucurbit(n)urilas que forma complexos com moléculas de tamanhos variados e pode encapsular tanto aminoesteroides quanto benzilisoquinolinas.

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