An uncontrolled trial of antimicrobial therapy (sulfonamide, tetracycline, ampicillin, or nitrofurantoin) in school-aged girls with persistent ASB,...

An uncontrolled trial of antimicrobial therapy (sulfonamide, tetracycline, ampicillin, or nitrofurantoin) in school-aged girls with persistent ASB, defined as ≥3 consecutive positive urine cultures, reported a reduction in the rate of recurrent bacteriuria of 25% in white and 40% in black girls; 10% of girls in this study developed clinical episodes of acute pyelonephritis. This study did not address long-term outcomes such as renal scarring.