What is the regulation mechanism of beta-oxidation of fatty acids?
a) The accumulation of ATP, NADH, and FADH2 leads to the depletion of NAD+, FA...
What is the regulation mechanism of beta-oxidation of fatty acids?
a) The accumulation of ATP, NADH, and FADH2 leads to the depletion of NAD+, FAD, and CoASH, reducing the formation of new mitochondrial acyl-CoA molecules and the speed of enzymatic reactions. b) The enzyme CPTI, which catalyzes the formation of acylcarnitine from cytosolic acyl-CoA and carnitine, is inhibited by malonyl-CoA. c) The regulation of the acetil-CoA-carboxilase in the liver is promoted by the insulin/glucagon ratio in the blood. d) The expression of fatty acid oxidation enzymes is regulated by transcription, with the activation of PPARα being one of the mechanisms that promote transcription.
A resposta correta é a alternativa d) A expressão das enzimas de oxidação de ácidos graxos é regulada por transcrição, sendo a ativação de PPARα um dos mecanismos que promovem a transcrição.
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