The maturation of B cells in the bone marrow is a controlled process and subject to various control points, minimizing the development of self-reac...

The maturation of B cells in the bone marrow is a controlled process and subject to various control points, minimizing the development of self-reactive B cells. Choose the alternative that correctly describes concepts about B lymphocyte maturation:


a. Soon after the pro-B lymphocyte stage, somatic recombination to generate new variable regions of the heavy chains will begin.
b. The immature B cell, when testing its receptor (BCR), if it binds weakly against our own antigens, it is eliminated by negative selection.
c. Hematopoietic stem cells are not capable of generating all cells of the immune and hematopoietic systems.
d. Hematopoietic cells that initiate their differentiation process into B lymphocytes will need IL-17 to maintain their high levels of proliferation.
e. The death of immature B cell clones that occurs through positive selection is known as clonal expansion.