What is the main difference between the clinical manifestations of leprosy in the tuberculoid and virchowian forms? I - In the tuberculoid form, t...
What is the main difference between the clinical manifestations of leprosy in the tuberculoid and virchowian forms?
I - In the tuberculoid form, there is a predominance of Th1 lymphocytes, while in the virchowian form, there is a predominance of suppressor T lymphocytes and Th2.
II - In the tuberculoid form, there is a production of pro-inflammatory cytokines that prevent bacterial proliferation, while in the virchowian form, there is a production of substances by the bacillus that favor its escape from oxidation.
III - In the tuberculoid form, there is a high cellular immunity, which can cause cutaneous and neural lesions, while in the virchowian form, there is a low cellular immunity, which favors the dissemination of the bacillus.
a) Only I is correct.
b) Only II is correct.
c) Only III is correct.
d) I and II are correct.
e) II and III are correct.
I - In the tuberculoid form, there is a predominance of Th1 lymphocytes, while in the virchowian form, there is a predominance of suppressor T lymphocytes and Th2.
II - In the tuberculoid form, there is a production of pro-inflammatory cytokines that prevent bacterial proliferation, while in the virchowian form, there is a production of substances by the bacillus that favor its escape from oxidation.
III - In the tuberculoid form, there is a high cellular immunity, which can cause cutaneous and neural lesions, while in the virchowian form, there is a low cellular immunity, which favors the dissemination of the bacillus.
a) Only I is correct.
b) Only II is correct.
c) Only III is correct.
d) I and II are correct.
e) II and III are correct.
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Ed 
A alternativa correta é a letra D) I e II estão corretas. A principal diferença entre as manifestações clínicas da hanseníase nas formas tuberculóide e virchowiana é que na forma tuberculóide há uma predominância de linfócitos Th1, que produzem citocinas pró-inflamatórias que impedem a proliferação bacteriana, enquanto na forma virchowiana há uma predominância de linfócitos T supressores e Th2, que produzem substâncias que favorecem a fuga do bacilo da oxidação. Além disso, na forma tuberculóide há uma alta imunidade celular, o que pode causar lesões cutâneas e neurais, enquanto na forma virchowiana há uma baixa imunidade celular, o que favorece a disseminação do bacilo.
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