What is the mechanism of recognition of the replication origin in bacteria? Ligand binding to the DNA Formation of the open complex Formation of th...
Ligand binding to the DNA
Formation of the open complex
Formation of the pre-priming complex
Activation of the origin
The formation of the open complex produces structural changes in the DNA, resulting in the separation of the two strands in the region of the 13 bp sequences.
The formation of the replication bubble, by strand separation, allows the positioning of the DnaB helicase.
The DnaA recruits the DnaB in the form of a DnaB-DnaC complex, which positions itself to start each replication fork.
The binding of DnaB to oriC represents the beginning of replication in response to DnaA binding, as it recruits primase to initiate the formation of the replisome.
a) I and II are correct.
b) II and III are correct.
c) II, III, and IV are correct.
d) All statements are correct.
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Ed 
The mechanism of recognition of the replication origin in bacteria is the formation of the open complex. The formation of the open complex produces structural changes in the DNA, resulting in the separation of the two strands in the region of the 13 bp sequences. The formation of the replication bubble, by strand separation, allows the positioning of the DnaB helicase. The DnaA recruits the DnaB in the form of a DnaB-DnaC complex, which positions itself to start each replication fork. The binding of DnaB to oriC represents the beginning of replication in response to DnaA binding, as it recruits primase to initiate the formation of the replisome. Therefore, the correct alternative is b) II and III are correct.
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