What are the steps for the formation of the PIC in the transcription process? a. TBP recognizes the promoter and causes a bend in the DNA around RN...
What are the steps for the formation of the PIC in the transcription process?
a. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
b. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
c. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIF enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIE binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
d. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the template strand; the non-template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
a. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
b. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
c. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIF enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIE binds to the non-template strand; the template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
d. TBP recognizes the promoter and causes a bend in the DNA around RNAPII and the C-terminal domain of TFIIB; the N-terminal domain of TFIIB positions the DNA in the TSS region in the catalytic center of RNAPII; TFIIE enters the complex and recruits TFIIH, which induces negative tension in the double helix of DNA, forcing its opening; TFIIF binds to the template strand; the non-template strand is positioned in the catalytic center of RNAPII and under the control of a TFIIB loop, abortive initiation occurs, synthesizing 6-nucleotide oligomers.
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Ed 
A alternativa correta é a letra B: TBP reconhece o promotor e causa uma curvatura no DNA ao redor de RNAPII e do domínio C-terminal de TFIIB; o domínio N-terminal de TFIIB posiciona o DNA na região TSS no centro catalítico de RNAPII; TFIIE entra no complexo e recruta TFIIH, que induz tensão negativa na dupla hélice do DNA, forçando sua abertura; TFIIF se liga à fita não-modelo; a fita modelo é posicionada no centro catalítico de RNAPII e sob o controle de um loop de TFIIB, ocorre a iniciação abortiva, sintetizando oligômeros de 6 nucleotídeos.
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