What are the proteins involved in the repair of double-strand breaks by non-homologous end joining? The main enzyme involved in non-homologous end...
What are the proteins involved in the repair of double-strand breaks by non-homologous end joining?
The main enzyme involved in non-homologous end joining is DNA-PK, which consists of a catalytic subunit (DNA-PKcs) and the DNA end-binding protein Ku.
The DNA-ligase IV and Xrcc4 proteins are also involved in the non-homologous end joining process.
The Mre11 complex is responsible for nucleotide trimming during non-homologous end joining.
a) Only statement I is correct.
b) Statements I and II are correct.
c) Statements II and III are correct.
d) All statements are correct.
The main enzyme involved in non-homologous end joining is DNA-PK, which consists of a catalytic subunit (DNA-PKcs) and the DNA end-binding protein Ku.
The DNA-ligase IV and Xrcc4 proteins are also involved in the non-homologous end joining process.
The Mre11 complex is responsible for nucleotide trimming during non-homologous end joining.
a) Only statement I is correct.
b) Statements I and II are correct.
c) Statements II and III are correct.
d) All statements are correct.
💡 1 Resposta
Ed 
A resposta correta é a alternativa (c) Statements II and III are correct. A proteína principal envolvida na junção de extremidades não homólogas é a DNA-PK, que consiste em uma subunidade catalítica (DNA-PKcs) e a proteína de ligação de extremidade de DNA Ku. Além disso, a ligase IV de DNA e as proteínas Xrcc4 também estão envolvidas no processo de junção de extremidades não homólogas. A complexa Mre11 é responsável pelo corte de nucleotídeos durante a junção de extremidades não homólogas. Portanto, as afirmações II e III estão corretas.
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