<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w0 h1" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg1.png"><div class="c x0 y0 w0 h2"><div class="t m0 x1 h3 y1 ff1 fs0 fc0 sc0 ls0 ws0">HEMATOLOGIA</div><div class="t m0 x2 h4 y2 ff2 fs1 fc0 sc0 ls0 ws1">G<span class="blank _0"> </span>U<span class="blank _0"> </span>S<span class="blank _0"> </span>T<span class="blank _0"> </span>A<span class="blank _0"> </span>V<span class="blank _0"> </span>O<span class="blank _0"> </span> <span class="blank _0"> </span>U<span class="blank _0"> </span>R<span class="blank _0"> </span>Z<span class="blank _0"> </span>Ê<span class="blank _0"> </span>D<span class="blank _0"> </span>A<span class="blank _0"> </span> <span class="blank _0"> </span>V<span class="blank _0"> </span>I<span class="blank _0"> </span>T<span class="blank _0"> </span>Ó<span class="blank _0"> </span>R<span class="blank _0"> </span>I<span class="blank _0"> </span>A</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,-7.829980]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w0 h1" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg2.png"><div class="c x0 y0 w0 h2"><div class="t m0 x2 h4 y2 ff3 fs1 fc1 sc0 ls0 ws1">G<span class="blank _0"> </span>U<span class="blank _0"> </span>S<span class="blank _0"> </span>T<span class="blank _0"> </span>A<span class="blank _0"> </span>V<span class="blank _0"> </span>O<span class="blank _0"> </span> <span class="blank _0"> </span>U<span class="blank _0"> </span>R<span class="blank _0"> </span>Z<span class="blank _0"> </span>Ê<span class="blank _0"> </span>D<span class="blank _0"> </span>A<span class="blank _0"> </span> <span class="blank _0"> </span>V<span class="blank _0"> </span>I<span class="blank _0"> </span>T<span class="blank _0"> </span>Ó<span class="blank _0"> </span>R<span class="blank _0"> </span>I<span class="blank _0"> </span>A</div><div class="t m0 x1 h3 y1 ff4 fs0 fc1 sc0 ls0 ws0">HEMATOLOGIA</div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,-7.829980]}"></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h1" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg3.png"><div class="c x0 y0 w0 h2"><div class="t m1 x3 h5 y3 ff5 fs2 fc0 sc0 ls0 ws2">Í<span class="blank"> </span>N<span class="blank"> </span>D<span class="blank"> </span>I<span class="blank"> </span>C<span class="blank"> </span>E</div><div class="t m0 x4 h6 y4 ff5 fs3 fc2 sc0 ls0 ws3">01<span class="blank"> </span><span class="ff6 fs4 fc3 ws1 v1">A<span class="blank _1"> </span>S<span class="blank _1"> </span>S<span class="blank _1"> </span>U<span class="blank _1"> </span>N<span class="blank _1"> </span>T<span class="blank _1"> </span>O<span class="blank _1"> </span>S<span class="blank _1"> </span> <span class="blank _1"> </span>E<span class="blank _1"> </span>M<span class="blank _1"> </span> <span class="blank _1"> </span>H<span class="blank _1"> </span>E<span class="blank _1"> </span>M<span class="blank _1"> </span>A<span class="blank _1"> </span>T<span class="blank _1"> </span>O<span class="blank _1"> </span>L<span class="blank _1"> </span>O<span class="blank _1"> </span>G<span class="blank _1"> </span>I<span class="blank _1"> </span>A</span></div><div class="t m0 x5 h7 y5 ff6 fs5 fc3 sc0 ls0 ws1">0<span class="blank _2"> </span>1<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>H<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>A<span class="blank _2"> </span>T<span class="blank _2"> </span>O<span class="blank _2"> </span>P<span class="blank _2"> </span>O<span class="blank _2"> </span>I<span class="blank _2"> </span>E<span class="blank _2"> </span>S<span class="blank _2"> </span>E</div><div class="t m0 x5 h7 y6 ff6 fs5 fc3 sc0 ls0 ws1">0<span class="blank _2"> </span>3<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>H<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>O<span class="blank _2"> </span>S<span class="blank _2"> </span>T<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span>I<span class="blank _2"> </span>A</div><div class="t m0 x5 h7 y7 ff6 fs5 fc3 sc0 ls0 ws1">0<span class="blank _2"> </span>9<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>H<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>O<span class="blank _2"> </span>T<span class="blank _2"> </span>R<span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>S<span class="blank _2"> </span>F<span class="blank _2"> </span>U<span class="blank _2"> </span>S<span class="blank _2"> </span>Ã<span class="blank _2"> </span>O</div><div class="t m0 x5 h7 y8 ff6 fs5 fc3 sc0 ls0 ws1">1<span class="blank _2"> </span>4<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>H<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>O<span class="blank _2"> </span>G<span class="blank _2"> </span>R<span class="blank _2"> </span>A<span class="blank _2"> </span>M<span class="blank _2"> </span>A</div><div class="t m0 x4 h6 y9 ff5 fs3 fc2 sc0 ls0 ws4">17<span class="blank"> </span><span class="ff6 fs4 fc3 ws5 v1">P<span class="blank"> </span>A<span class="blank"> </span>T<span class="blank"> </span>O<span class="blank"> </span>L<span class="blank"> </span>O<span class="blank"> </span>G<span class="blank"> </span>I<span class="blank"> </span>A<span class="blank"> </span>S</span></div><div class="t m0 x6 h7 ya ff6 fs5 fc3 sc0 ls0 ws1">1<span class="blank _2"> </span>7<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 yb ff6 fs5 fc3 sc0 ls0 ws1">2<span class="blank _2"> </span>8<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>H<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>O<span class="blank _2"> </span>G<span class="blank _2"> </span>L<span class="blank _2"> </span>O<span class="blank _2"> </span>B<span class="blank _2"> </span>I<span class="blank _2"> </span>N<span class="blank _2"> </span>O<span class="blank _2"> </span>P<span class="blank _2"> </span>A<span class="blank _2"> </span>T<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 yc ff6 fs5 fc3 sc0 ls0 ws1">3<span class="blank _2"> </span>6<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>L<span class="blank _2"> </span>E<span class="blank _2"> </span>U<span class="blank _2"> </span>C<span class="blank _2"> </span>E<span class="blank _2"> </span>M<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>G<span class="blank _2"> </span>U<span class="blank _2"> </span>D<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>E<span class="blank _2"> </span> <span class="blank _2"> </span>C<span class="blank _2"> </span>R<span class="blank _2"> </span>Ô<span class="blank _2"> </span>N<span class="blank _2"> </span>I<span class="blank _2"> </span>C<span class="blank _2"> </span>A<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 yd ff6 fs5 fc3 sc0 ls0 ws1">5<span class="blank _2"> </span>0<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>N<span class="blank _2"> </span>E<span class="blank _2"> </span>U<span class="blank _2"> </span>T<span class="blank _2"> </span>R<span class="blank _2"> </span>O<span class="blank _2"> </span>P<span class="blank _2"> </span>E<span class="blank _2"> </span>N<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span> <span class="blank _2"> </span>F<span class="blank _2"> </span>E<span class="blank _2"> </span>B<span class="blank _2"> </span>R<span class="blank _2"> </span>I<span class="blank _2"> </span>L</div><div class="t m0 x6 h7 ye ff6 fs5 fc3 sc0 ls0 ws1">5<span class="blank _2"> </span>3<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>T<span class="blank _2"> </span>R<span class="blank _2"> </span>O<span class="blank _2"> </span>M<span class="blank _2"> </span>B<span class="blank _2"> </span>O<span class="blank _2"> </span>S<span class="blank _2"> </span>E<span class="blank _2"> </span> <span class="blank _2"> </span>V<span class="blank _2"> </span>E<span class="blank _2"> </span>N<span class="blank _2"> </span>O<span class="blank _2"> </span>S<span class="blank _2"> </span>A<span class="blank _2"> </span> <span class="blank _2"> </span>P<span class="blank _2"> </span>R<span class="blank _2"> </span>O<span class="blank _2"> </span>F<span class="blank _2"> </span>U<span class="blank _2"> </span>N<span class="blank _2"> </span>D<span class="blank _2"> </span>A</div><div class="t m0 x6 h7 yf ff6 fs5 fc3 sc0 ls0 ws1">5<span class="blank _2"> </span>7<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>D<span class="blank _2"> </span>I<span class="blank _2"> </span>S<span class="blank _2"> </span>T<span class="blank _2"> </span>Ú<span class="blank _2"> </span>R<span class="blank _2"> </span>B<span class="blank _2"> </span>I<span class="blank _2"> </span>O<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>P<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>Q<span class="blank _2"> </span>U<span class="blank _2"> </span>E<span class="blank _2"> </span>T<span class="blank _2"> </span>Á<span class="blank _2"> </span>R<span class="blank _2"> </span>I<span class="blank _2"> </span>O<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 y10 ff6 fs5 fc3 sc0 ls0 ws1">6<span class="blank _2"> </span>5<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>D<span class="blank _2"> </span>I<span class="blank _2"> </span>S<span class="blank _2"> </span>T<span class="blank _2"> </span>Ú<span class="blank _2"> </span>R<span class="blank _2"> </span>B<span class="blank _2"> </span>I<span class="blank _2"> </span>O<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>D<span class="blank _2"> </span>A<span class="blank _2"> </span> <span class="blank _2"> </span>C<span class="blank _2"> </span>O<span class="blank _2"> </span>A<span class="blank _2"> </span>G<span class="blank _2"> </span>U<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>Ç<span class="blank _2"> </span>Ã<span class="blank _2"> </span>O</div><div class="t m0 x6 h7 y11 ff6 fs5 fc3 sc0 ls0 ws1">7<span class="blank _2"> </span>5<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>L<span class="blank _2"> </span>I<span class="blank _2"> </span>N<span class="blank _2"> </span>F<span class="blank _2"> </span>O<span class="blank _2"> </span>M<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>E<span class="blank _2"> </span> <span class="blank _2"> </span>D<span class="blank _2"> </span>I<span class="blank _2"> </span>S<span class="blank _2"> </span>C<span class="blank _2"> </span>R<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>P<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>S<span class="blank _2"> </span>M<span class="blank _2"> </span>O<span class="blank _2"> </span>C<span class="blank _2"> </span>I<span class="blank _2"> </span>T<span class="blank _2"> </span>Á<span class="blank _2"> </span>R<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>S</div><div class="t m0 x4 h6 y12 ff5 fs3 fc2 sc0 ls0 ws6">82<span class="blank"> </span><span class="ff6 fs4 fc3 ws7 v1">F<span class="blank"> </span>A<span class="blank"> </span>R<span class="blank"> </span>M<span class="blank"> </span>A<span class="blank"> </span>C<span class="blank"> </span>O<span class="blank"> </span>L<span class="blank"> </span>O<span class="blank"> </span>G<span class="blank"> </span>I<span class="blank"> </span>A</span></div><div class="t m0 x6 h7 y13 ff6 fs5 fc3 sc0 ls0 ws1">8<span class="blank _2"> </span>2<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>G<span class="blank _2"> </span>R<span class="blank _2"> </span>E<span class="blank _2"> </span>G<span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>E<span class="blank _2"> </span>S<span class="blank _2"> </span> <span class="blank _2"> </span>P<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>Q<span class="blank _2"> </span>U<span class="blank _2"> </span>E<span class="blank _2"> </span>T<span class="blank _2"> </span>Á<span class="blank _2"> </span>R<span class="blank _2"> </span>I<span class="blank _2"> </span>O<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 y14 ff6 fs5 fc3 sc0 ls0 ws1">8<span class="blank _2"> </span>4<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>I<span class="blank _2"> </span>C<span class="blank _2"> </span>O<span class="blank _2"> </span>A<span class="blank _2"> </span>G<span class="blank _2"> </span>U<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>E<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 y15 ff6 fs5 fc3 sc0 ls0 ws1">8<span class="blank _2"> </span>7<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>I<span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>Ê<span class="blank _2"> </span>M<span class="blank _2"> </span>I<span class="blank _2"> </span>C<span class="blank _2"> </span>O<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 y16 ff6 fs5 fc3 sc0 ls0 ws1">9<span class="blank _2"> </span>0<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>A<span class="blank _2"> </span>N<span class="blank _2"> </span>T<span class="blank _2"> </span>I<span class="blank _2"> </span>N<span class="blank _2"> </span>E<span class="blank _2"> </span>O<span class="blank _2"> </span>P<span class="blank _2"> </span>L<span class="blank _2"> </span>Á<span class="blank _2"> </span>S<span class="blank _2"> </span>I<span class="blank _2"> </span>C<span class="blank _2"> </span>O<span class="blank _2"> </span>S</div><div class="t m0 x6 h7 y17 ff6 fs5 fc3 sc0 ls0 ws1">9<span class="blank _2"> </span>2<span class="blank _2"> </span> <span class="blank _2"> </span>-<span class="blank _2"> </span> <span class="blank _2"> </span>T<span class="blank _2"> </span>A<span class="blank _2"> </span>B<span class="blank _2"> </span>E<span class="blank _2"> </span>L<span class="blank _2"> </span>A<span class="blank _2"> </span>S</div><div class="t m0 x4 h6 y18 ff5 fs3 fc2 sc0 ls0 ws8">103<span class="blank"> </span><span class="ff6 fs4 fc3 ws9 v1">R<span class="blank"> </span>E<span class="blank"> </span>F<span class="blank"> </span>E<span class="blank"> </span>R<span class="blank"> </span>Ê<span class="blank"> </span>N<span class="blank"> </span>C<span class="blank"> </span>I<span class="blank"> </span>A<span class="blank"> </span>S</span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,-7.829980]}"></div></div> <div id="pf4" class="pf w1 h8" data-page-no="4"><div class="pc pc4 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x0 y19 w0 h9" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg4.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"><span class="fc4 sc0"> </span></div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1"><span class="fc4 sc0">1</span><span class="fc4 sc0"> </span></div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1"><span class="fc4 sc0">Gu</span>st<span class="fc4 sc0">av</span><span class="fc4 sc0">o Urzê</span><span class="fc4 sc0">d</span><span class="fc4 sc0">a</span><span class="fc4 sc0"> V</span><span class="fc4 sc0">itó</span>ria<span class="fc4 sc0"> </span></div></div><div class="c x0 y0 w2 h8"><div class="t m0 xb he y20 ff9 fs8 fc1 sc1 ls0 ws1">HEMATOLO<span class="blank _3"></span>GIA </div><div class="t m0 x2 hf y21 ff9 fs9 fc1 sc1 ls0 ws1">ASSUNTOS EM HE<span class="blank _3"> </span>MATOLOGIA<span class="blank _3"> </span> </div><div class="t m0 x7 h10 y22 ff9 fsa fc1 sc1 ls0 ws1"> </div><div class="t m0 x7 h11 y23 ff8 fsa fc1 sc0 ls0 ws1">- Hematopoiese: </div><div class="t m0 xc h11 y24 ff8 fsa fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 h12 y25 ffa fs7 fc1 sc0 ls0 ws1">Conceitos: </div><div class="t m0 xd h12 y26 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Processo contínuo de formação e re<span class="blank _5"></span>novação dos elementos figura<span class="blank _5"></span>dos do </span></div><div class="t m0 xe h12 y27 ffa fs7 fc1 sc0 ls0 ws1">sangue. </div><div class="t m0 xd h12 y28 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Divisão <span class="blank _2"> </span>da <span class="blank _2"> </span>célula <span class="blank _2"> </span>tronco <span class="blank _2"> </span>em <span class="blank _2"> </span>outro <span class="blank _2"> </span>célula <span class="blank _2"> </span>tronco <span class="blank _2"> </span>(autorrenovação) <span class="blank _2"> </span>e <span class="blank _2"> </span>uma </span></div><div class="t m0 xe h12 y29 ffa fs7 fc1 sc0 ls0 ws1">progenitora. </div><div class="t m0 xf h12 y2a ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Tronco embrionária ou adultas. </span></div><div class="t m0 xf h12 y2b ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Totipotentes: forma um organismo. </span></div><div class="t m0 xf h12 y2c ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Pluripotentes: forma tecidos. </span></div><div class="t m0 xf h12 y2d ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Multipotentes: forma alguns tecidos. </span></div><div class="t m0 xd h12 y2e ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Progenitores: </span></div><div class="t m0 xf h12 y2f ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Mieloides: hemácias, granulócitos, megacariócitos e macrófagos. </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w1 h8" data-page-no="5"><div class="pc pc5 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x7 y19 w5 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg5.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">2 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 xf h12 y30 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Linfoides: NK e linfócitos B e T. </span></div><div class="t m0 x7 h12 y31 ffa fs7 fc1 sc0 ls0 ws1">Granulócitos: </div><div class="t m0 xd h12 y32 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Mieloblastos <span class="blank _2"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>pró<span class="blank _3"> </span>-mielócito <span class="blank _2"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>mielócito <span class="blank _2"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>metamielócito <span class="blank _7"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>bastão <span class="blank _2"> </span></span><span class="ffd">\u2192<span class="ffa ws1"> </span></span></div><div class="t m0 xe h12 y33 ffa fs7 fc1 sc0 ls0 ws1">maduros (basófilos, eosinófilos e neutrófilos). </div><div class="t m0 xf h12 y34 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Maduros <span class="blank _1"> </span>ficam <span class="blank _7"> </span>na <span class="blank _1"> </span>corrente <span class="blank _1"> </span>sanguínea, <span class="blank _7"> </span>os <span class="blank _1"> </span>demais, <span class="blank _7"> </span>normalmente, </span></div><div class="t m0 x10 h12 y35 ffa fs7 fc1 sc0 ls0 ws1">dicam na MO. </div><div class="t m0 xd h12 y36 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Infecções podem aumentar formas jovens no <span class="blank _3"> </span>sangue periférico <span class="blank _3"> </span><span class="ffd ls1">\u2192</span> desvio </span></div><div class="t m0 xe h12 y37 ffa fs7 fc1 sc0 ls0 ws1">a esquerda. </div><div class="t m0 x7 h12 y38 ffa fs7 fc1 sc0 ls0 ws1">Microambiente medular: </div><div class="t m0 xd h12 y39 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Células <span class="blank"> </span>do <span class="blank _8"> </span>estroma <span class="blank _8"> </span>que <span class="blank"> </span>secretam <span class="blank _8"> </span>a <span class="blank"> </span>m<span class="blank _5"></span>atriz <span class="blank"> </span>extracelular <span class="blank _8"> </span>e <span class="blank"> </span>fa<span class="blank _5"></span>tores <span class="blank _8"> </span>de </span></div><div class="t m0 xe h12 y3a ffa fs7 fc1 sc0 ls0 ws1">crescimento. </div><div class="t m0 xd h12 y3b ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>No <span class="blank _9"> </span>estroma <span class="blank _9"> </span>há <span class="blank _9"> </span>células <span class="blank _9"> </span>mesenquimais, <span class="blank _4"> </span>adipócitos, <span class="blank _9"> </span>fibroblastos, </span></div><div class="t m0 xe h12 y3c ffa fs7 fc1 sc0 ls0 ws1">osteoblastos, <span class="blank _0"> </span>célul<span class="blank _5"></span>as <span class="blank _a"> </span>endoteliais <span class="blank _a"> </span>e <span class="blank _0"> </span>macrófagos <span class="blank _a"> </span><span class="ffd ls1">\u2192</span> <span class="blank _0"> </span>secretam <span class="blank _a"> </span>moléculas<span class="blank _5"></span> </div><div class="t m0 xe h12 y3d ffa fs7 fc1 sc0 ls0 ws1">extracelulares <span class="blank _8"> </span>como <span class="blank _8"> </span>c<span class="blank _5"></span>olágeno, <span class="blank _8"> </span>glicoproteínas <span class="blank _0"> </span>e <span class="blank"> </span>glicosaminoglicanos <span class="blank _0"> </span>e </div><div class="t m0 xe h12 y3e ffa fs7 fc1 sc0 ls0 ws1">fatores de crescimento necessários para sobrevida da célula<span class="blank _3"> </span>-tronco. </div><div class="t m0 xd h12 y3f ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>EPO <span class="blank _b"> </span>(90% <span class="blank _b"> </span>sintetizada <span class="blank _b"> </span>pelos<span class="blank _5"></span> <span class="blank _b"> </span>rins) <span class="blank _b"> </span><span class="ffd ls1">\u2192</span> <span class="blank _b"> </span>qualquer <span class="blank _b"> </span>condição <span class="blank _b"> </span>que <span class="blank _c"> </span>caus<span class="ls4">a </span></span></div><div class="t m0 xe h12 y40 ffa fs7 fc1 sc0 ls0 ws1">diminuição do O2 <span class="blank _3"> </span>a ser transportado <span class="blank _3"> </span>para os te<span class="blank _3"> </span>cidos provoca a <span class="blank _3"> </span>formação<span class="blank _5"></span> </div><div class="t m0 xe h12 y41 ffa fs7 fc1 sc0 ls0 ws1">desse hormônio. </div><div class="t m0 xd h12 y42 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Trombopoetina é sintetizada pelo fígado. </span></div><div class="t m0 xd h12 y43 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Citocinas: IL, CSF, TNF, IFN, TGF. </span></div><div class="t m0 x7 h12 y44 ffa fs7 fc1 sc0 ls0 ws1">Órgãos hematopoiéticos: </div><div class="t m0 xd h12 y45 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Período intrauterino ou embrionário: saco vitelino. </span></div><div class="t m0 xd h12 y46 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Período hepatoesplênico ou fetal: </span></div><div class="t m0 xf h12 y47 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fígado <span class="blank _2"> </span>e <span class="blank _2"> </span>baço: <span class="blank _2"> </span>sexta <span class="blank _3"> </span>sem<span class="blank _3"> </span>ana <span class="blank _2"> </span>de <span class="blank _2"> </span>gestaç<span class="blank _5"></span>ão <span class="blank _2"> </span>até <span class="blank _2"> </span>6<span class="blank _3"> </span>-7 <span class="blank _2"> </span>meses <span class="blank _2"> </span>são <span class="blank _3"> </span>os </span></div><div class="t m0 x10 h12 y48 ffa fs7 fc1 sc0 ls0 ws1">principais <span class="blank _a"> </span>órgãos <span class="blank _d"> </span>hematopoiéticos <span class="blank _d"> </span>e <span class="blank _a"> </span>continuam <span class="blank _d"> </span>a <span class="blank _d"> </span>p<span class="blank _3"> </span>roduzir <span class="blank _d"> </span>até <span class="blank _d"> </span>2 </div><div class="t m0 x10 h12 y49 ffa fs7 fc1 sc0 ls0 ws1">semanas após o nascimento. </div><div class="t m0 xf h12 y4a ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Placenta também contribui para hematopoiese no período fet<span class="blank _5"></span>al.<span class="blank _3"> </span> </span></div><div class="t m0 xd h12 y4b ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Período medular fetal, infância e vida adulta: </span></div><div class="t m0 xf h12 y4c ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Por volt<span class="blank _5"></span>a <span class="blank _5"></span>de <span class="blank _5"></span>6-7 <span class="blank _5"></span>meses <span class="blank _5"></span>da <span class="blank _5"></span>vida <span class="blank _5"></span>fetal <span class="blank _5"></span>a <span class="blank _5"></span>MO <span class="blank _5"></span>inic<span class="blank _5"></span>ia <span class="blank _5"></span>a <span class="blank _5"></span>produção <span class="blank _5"></span>celular </span></div><div class="t m0 x10 h12 y4d ffa fs7 fc1 sc0 ls0 ws1">de modo progressivo. </div><div class="t m0 xf h12 y4e ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Após <span class="blank _7"> </span>o <span class="blank _7"> </span>nascimento <span class="blank _7"> </span>a <span class="blank _2"> </span>hematopo<span class="blank _3"> </span>iese <span class="blank _2"> </span>de<span class="blank _3"> </span> <span class="blank _2"> </span>eritrócitos, <span class="blank _7"> </span>granulócitos <span class="blank _7"> </span>e </span></div><div class="t m0 x10 h12 y4f ffa fs7 fc1 sc0 ls0 ws1">plaquetas passa a ocorrer apenas na MO. </div><div class="t m0 xf h12 y50 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Até 5 anos: só MO vermelha <span class="ffd ls2">\u2192</span> vai virando amarela. </span></div><div class="t m0 x11 h12 y51 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Adulto <span class="blank _e"> </span>tem <span class="blank _e"> </span>mais <span class="blank _e"> </span>vermelha <span class="blank _e"> </span>no <span class="blank _e"> </span>esqu<span class="blank _5"></span>eleto <span class="blank _e"> </span>central <span class="blank _e"> </span>e<span class="blank _5"></span> </span></div><div class="t m0 x12 h12 y52 ffa fs7 fc1 sc0 ls0 ws1">extremidades próximas ao fémur e úmero. </div><div class="t m0 x11 h12 y53 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Caso de necessidade a amarela é<span class="blank _3"> </span> substituída por vermelha </span></div><div class="t m0 x12 h12 y54 ffa fs7 fc1 sc0 ls0 ws1">por meio de estímulos intensos e contínuos. </div><div class="t m0 x11 h12 y55 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Fígado <span class="blank"> </span>e <span class="blank _0"> </span>baço <span class="blank _8"> </span>podem <span class="blank _8"> </span>retornar <span class="blank _8"> </span>ao <span class="blank _8"> </span>p<span class="blank _5"></span>apel <span class="blank _8"> </span>hematopoiét<span class="blank _3"> </span>ico </span></div><div class="t m0 x12 h12 y56 ffa fs7 fc1 sc0 ls0 ws1">quando preciso (hematopoiese extramedular). </div><div class="t m0 x11 h12 y57 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Granulócitos <span class="blank _4"> </span>são <span class="blank _4"> </span>armazenados <span class="blank _4"> </span>na <span class="blank _4"> </span>MO <span class="blank _4"> </span>até <span class="blank _4"> </span>serem </span></div><div class="t m0 x12 h12 y58 ffa fs7 fc1 sc0 ls0 ws1">necessários. </div><div class="t m0 x11 h12 y59 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>T e B são produzidos e armazenados em órgãos linfoides: </span></div><div class="t m0 x13 h12 y5a ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Primários (MO e timo) e secundários. </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w1 h8" data-page-no="6"><div class="pc pc6 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x7 y19 w5 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg6.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">3 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 x13 h12 y5b ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>B: maduro <span class="ffd ls1">\u2192</span> plasmócitos ou memória. </span></div><div class="t m0 x13 h12 y5c ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>T: seleção negativa e positiva <span class="ffd ls1">\u2192</span> CD4 e CD8. </span></div><div class="t m0 x13 h12 y5d ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>NK: <span class="blank _3"> </span>CD8 se<span class="blank _3"> </span>m <span class="blank _3"> </span>receptor de <span class="blank _3"> </span>célula<span class="blank _3"> </span>s T <span class="blank _2"> </span><span class="ffd ls1">\u2192</span> ma<span class="blank _3"> </span>tar células </span></div><div class="t m0 x14 h12 y5e ffa fs7 fc1 sc0 ls0 ws1">com <span class="blank _2"> </span>baixa <span class="blank _3"> </span>expressão <span class="blank _3"> </span>d<span class="blank _3"> </span>e <span class="blank _2"> </span>HL<span class="blank _5"></span>A <span class="blank _2"> </span>I<span class="blank _5"></span> <span class="blank _2"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>d<span class="blank _5"></span>urante <span class="blank _2"> </span>in<span class="blank _5"></span>fecções </div><div class="t m0 x14 h12 y5f ffa fs7 fc1 sc0 ls0 ws1">virais ou células malignas. </div><div class="t m0 xf h12 y60 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>200 milhões/dia de hemácias <span class="blank _3"> </span><span class="ffd wsa">\u2192</span> reposição. </span></div><div class="t m0 xf h12 y61 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Eritropoiese: </span></div><div class="t m0 x11 h12 y62 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Pró-eritroblasto <span class="blank _f"> </span></span><span class="ls1">\u2192<span class="ffa ls0 ws1"> <span class="blank _f"> </span>early <span class="blank _10"> </span>eritroblasto <span class="blank _f"> </span>(produção <span class="blank _10"> </span>de </span></span></div><div class="t m0 x12 h12 y63 ffa fs7 fc1 sc0 ls0 ws1">ribossomo) <span class="blank _11"> </span><span class="ffd ls1">\u2192</span> <span class="blank _11"> </span>late/policromatófilo <span class="blank _11"> </span>(Hb) <span class="blank _11"> </span><span class="ffd ls1">\u2192</span> </div><div class="t m0 x12 h12 y64 ffa fs7 fc1 sc0 ls0 ws1">normoblasto/ortocromático <span class="ffd ls1">\u2192</span> reticulócitos (dura <span class="blank _5"></span>1-3 dias n<span class="blank _5"></span>a </div><div class="t m0 x12 h12 y65 ffa fs7 fc1 sc0 ls0 ws1">MO <span class="blank _3"> </span>e <span class="blank _2"> </span>vai <span class="blank _3"> </span>para <span class="blank _2"> </span>o <span class="blank _3"> </span>sangue <span class="blank _2"> </span>por <span class="blank _3"> </span>1<span class="blank _3"> </span>-2 <span class="blank _3"> </span>dias, <span class="blank _2"> </span>depois <span class="blank _3"> </span>vira <span class="blank _3"> </span>hem<span class="blank _3"> </span>ácia;<span class="blank _5"></span> </div><div class="t m0 x12 h12 y66 ffa fs7 fc1 sc0 ls0 ws1">sem núcleo, mas com organelas) <span class="ffd ls1">\u2192</span> hemácias. </div><div class="t m0 xf h12 y67 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Vida média. </span></div><div class="t m0 x11 h12 y68 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Hemácia: 120 dias. </span></div><div class="t m0 x11 h12 y69 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Plaquetas: 7-10 dias <span class="blank _5"></span><span class="ffd ls2">\u2192<span class="ffa ls0"> depois fagocitadas <span class="blank _5"></span>por macrófagos. </span></span></span></div><div class="t m0 x11 h12 y6a ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Eosinófilos e basófilos: alguns dias. </span></div><div class="t m0 x11 h12 y6b ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Linfócitos: semanas a anos. </span></div><div class="t m0 x11 h12 y6c ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Neutrófilos e monócitos: algumas horas. </span></div><div class="t m0 x15 h12 y6d ffa fs7 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 h11 y6e ff8 fsa fc1 sc0 ls0 ws1">- Hemostasia: </div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf7" class="pf w1 h8" data-page-no="7"><div class="pc pc7 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x16 y19 w6 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg7.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">4 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 x17 h11 y6f ff8 fsa fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 h12 y70 ffa fs7 fc1 sc0 ls0 ws1">Primária: </div><div class="t m0 x18 h12 y71 ffa fs7 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 h12 y72 ffa fs7 fc1 sc0 ls0 ws1">Endotélio saudável: </div><div class="t m0 xd h12 y73 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Evita exposição do subendotélio ao sangue. </span></div><div class="t m0 xd h12 y74 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Produz NO, prostaglandinas e CD39 (ADP-difosfatase). </span></div><div class="t m0 xf h12 y75 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Repele plaquetas <span class="ffd ls1">\u2192</span> antiplaquetários. </span></div><div class="t m0 xd h12 y76 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Expressa proteínas: </span></div><div class="t m0 xf h12 y77 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Heparan-sulfato <span class="blank _a"> </span>(ancora <span class="blank _d"> </span>antitrombina <span class="blank _a"> </span>III <span class="blank _a"> </span>(ATIII) <span class="blank _a"> </span><span class="ffd ls1">\u2192</span> <span class="blank _d"> </span>de<span class="blank _3"> </span>grada <span class="blank _d"> </span>FIIa, </span></div><div class="t m0 x10 h12 y78 ffa fs7 fc1 sc0 ls0 ws1">FXa e FIXa. </div><div class="t m0 x11 h12 y79 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Princípio das heparinas. </span></div><div class="t m0 xf h12 y7a ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>TFPI <span class="ffd ls5">\u2192</span> inibidor de fator tecidual. </span></div><div class="t m0 xf h12 y7b ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Trombomodulina <span class="blank _c"> </span><span class="ffd ls1">\u2192</span> <span class="blank"> </span>modula <span class="blank _c"> </span>FI<span class="blank _5"></span>Ia <span class="blank _c"> </span><span class="ffd wsa">\u2192<span class="blank _5"></span><span class="ffa ws1"> <span class="blank _12"> </span>+ <span class="blank"> </span>p<span class="blank _3"> </span>roteína <span class="blank"> </span>C <span class="blank _12"> </span>(PC) <span class="blank _12"> </span>e <span class="blank _12"> </span>seu </span></span></span></div><div class="t m0 x10 h12 y7c ffa fs7 fc1 sc0 ls0 ws1">receptor (EPCR) + proteína s (PS) <span class="blank _3"> </span><span class="ffd ls1">\u2192</span> degrada FVa e FVIIIa. </div><div class="t m0 x11 h12 y7d ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Anticoagulante. </span></div><div class="t m0 xd h12 y7e ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Produz u-PA <span class="blank _5"></span>e<span class="blank _5"></span> t-P<span class="blank _5"></span>A <span class="ffd wsa">\u2192<span class="blank _5"></span><span class="ffa ws1"> <span class="blank _5"></span>ativa <span class="blank _5"></span>plasminogênio <span class="blank _5"></span>em <span class="blank _5"></span>plas<span class="blank _5"></span>mina <span class="ffd ls1">\u2192</span> <span class="blank _5"></span>quebra<span class="blank _5"></span> f<span class="blank _5"></span>ibrina </span></span></span></div><div class="t m0 xe h12 y7f ffa fs7 fc1 sc0 ls0 ws1">em produtos. </div><div class="t m0 xf h12 y80 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Trombolítico. </span></div><div class="t m0 xd h12 y81 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Produz PAI-<span class="ls6">1 </span></span><span class="ffd">\u2192<span class="ffa ws1"> inibe t-PA e u-PA. </span></span></div><div class="t m0 xd h12 y82 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Evita trombos e lisa coágulos. </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf8" class="pf w1 h8" data-page-no="8"><div class="pc pc8 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x16 y19 w6 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg8.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">5 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 x7 h12 y83 ffa fs7 fc1 sc0 ls0 ws1">Plaquetas: </div><div class="t m0 xd h12 y84 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Ativação: </span></div><div class="t m0 xf h12 y85 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Estimulantes: trombina, colágeno, ADP, epinefrina. </span></div><div class="t m0 x11 h12 y86 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Adesão <span class="blank _5"></span><span class="ffd ls1">\u2192<span class="ffa ls0"> <span class="blank _13"></span>agregação <span class="blank _13"></span><span class="ffd ls2">\u2192<span class="ffa ls0"> <span class="blank _5"></span>secreção <span class="blank _14"></span><span class="ffd ls1">\u2192<span class="ffa ls0"> <span class="blank _13"></span>estímu<span class="blank _3"> </span>lo <span class="blank _13"></span>a <span class="blank _14"></span>secundária. </span></span></span></span></span></span></span></div><div class="t m0 xf h12 y87 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Tem <span class="blank _2"> </span>vasoconstrição <span class="blank _2"> </span>também <span class="blank _7"> </span><span class="ffd ls1">\u2192</span> <span class="blank _2"> </span>diminui <span class="blank _7"> </span>sangue <span class="blank _2"> </span>perdido <span class="blank _2"> </span>e <span class="blank _2"> </span>o <span class="blank _2"> </span>fluxo </span></div><div class="t m0 x10 h12 y88 ffa fs7 fc1 sc0 ls0 ws1">de sangue no local. </div><div class="t m0 x11 h12 y89 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Reflexo neurogênico. </span></div><div class="t m0 x11 h12 y8a ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Constrição miogênica. </span></div><div class="t m0 x11 h12 y8b ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Diminuição de prostaciclina e NO. </span></div><div class="t m0 x11 h12 y8c ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Aumento de endotelina. </span></div><div class="t m0 xf h12 y8d ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Perda de propriedades antiplaquetárias e anti<span class="blank _5"></span>coagulantes.<span class="blank _3"> </span> </span></div><div class="t m0 xd h12 y8e ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Adesão: </span></div><div class="t m0 xf h12 y8f ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>FvW liga ao subendotélio. </span></div><div class="t m0 x11 h12 y90 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>GPIb/V-IX da plaqueta liga nele. </span></div><div class="t m0 x11 h12 y91 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Ligação <span class="blank _a"> </span>fra<span class="blank _3"> </span>ca <span class="blank _a"> </span>e <span class="blank _a"> </span>rápida <span class="blank _0"> </span></span><span class="ls1">\u2192<span class="ffa ls0 ws1"> <span class="blank _a"> </span>liga <span class="blank _a"> </span>e <span class="blank _0"> </span>desliga <span class="blank _a"> </span></span><span class="ls0 wsa">\u2192<span class="ffa ws1"> <span class="blank _a"> </span>desacelera <span class="blank _0"> </span>a<span class="blank _5"></span> </span></span></span></div><div class="t m0 x12 h12 y92 ffa fs7 fc1 sc0 ls0 ws1">plaqueta. </div><div class="t m0 x11 h12 y93 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Começa a rolar no endotélio. </span></div><div class="t m0 x11 h12 y94 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Deficiência dessa GP: Bernard<span class="blank _3"> </span>-Soulier. </span></div><div class="t m0 xf h12 y95 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>GPVI: </span></div><div class="t m0 x11 h12 y96 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Liga <span class="blank _a"> </span>no <span class="blank _d"> </span>colágeno <span class="blank _a"> </span></span><span class="ls1">\u2192<span class="ffa ls0 ws1"> <span class="blank _d"> </span>d<span class="blank _3"> </span>iminiu <span class="blank _d"> </span>afinidade<span class="blank _3"> </span>, <span class="blank _d"> </span>mas <span class="blank _d"> </span>a<span class="blank _3"> </span>tiva <span class="blank _d"> </span>as <span class="blank _a"> </span>vias </span></span></div><div class="t m0 x12 h12 y97 ffa fs7 fc1 sc0 ls0 ws1">intracelulares e expressão de GPIa/IIa. </div><div class="t m0 xf h12 y98 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>GPIa/IIa (alfa2beta1): </span></div><div class="t m0 x11 h12 y99 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Ancoragem da plaqueta ao subendotélio. </span></div><div class="t m0 x11 h12 y9a ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Outras plaquetas são atraídas. </span></div><div class="t m0 x11 h12 y9b ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Ativação pode ocorrer mesmo na ausência de colágeno. </span></div><div class="t m0 x13 h12 y9c ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>PAR1 e PAR4 <span class="ffd ls2">\u2192</span> liga na FIIa. </span></div><div class="t m0 x19 h12 y9d ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Vorapaxar inibe. </span></div><div class="t m0 xd h12 y9e ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Agregação: </span></div><div class="t m0 xf h12 y9f ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Estímulos: ADP, colágeno e TXA2. </span></div><div class="t m0 x11 h12 ya0 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>ADP: </span></div><div class="t m0 x13 h12 ya1 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Receptores P2Y1 e P2Y12. </span></div><div class="t m0 x19 h12 ya2 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Mobiliza <span class="blank _10"> </span>Ca <span class="blank _15"> </span>intracelular, <span class="blank _15"> </span>expressão <span class="blank _15"> </span>de </span></div><div class="t m0 x1a h12 ya3 ffa fs7 fc1 sc0 ls0 ws1">GPIIb/IIIa e mudança de forma. </div><div class="t m0 x1b h12 ya4 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Plaquetas grudam entre si. </span></div><div class="t m0 x13 h12 ya5 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Própria plaqueta ou próximas. </span></div><div class="t m0 xf h12 ya6 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Estimulam fosfolipase <span class="blank _14"></span>A2 <span class="ffd ls1">\u2192</span> transforma <span class="blank _5"></span>fosfolipídios de <span class="blank _14"></span>m<span class="blank _3"> </span>embrana </span></div><div class="t m0 x10 h12 ya7 ffa fs7 fc1 sc0 ls0 ws1">em ácido araquidônico (AA). </div><div class="t m0 x11 h12 ya8 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>COX <span class="blank _0"> </span>transforma <span class="blank _0"> </span>A<span class="blank _3"> </span>A <span class="blank _0"> </span>em <span class="blank _0"> </span>TXA2 <span class="blank _8"> </span></span><span class="ls1">\u2192<span class="ffa ls0 ws1"> <span class="blank _0"> </span>expressa <span class="blank _0"> </span>GPIIb/IIIa <span class="blank _0"> </span></span><span class="ls0 wsa">\u2192<span class="ffa ws1"> </span></span></span></div><div class="t m0 x12 h12 ya9 ffa fs7 fc1 sc0 ls0 ws1">aumenta Ca intracelular <span class="ffd ls1">\u2192</span> exocitose de grânulos. </div><div class="t m0 xf h12 yaa ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Sinalização inside-out. </span></div><div class="t m0 xf h12 y2b ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Podem se agregar por FvW também. </span></div><div class="t m0 x11 h12 y2c ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Liga no GPIIb/IIIa. </span></div><div class="t m0 x13 h12 yab ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Retração plaquetária. </span></div><div class="t m0 x13 h12 yac ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Outside-in. </span></div><div class="t m0 x13 h12 yad ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Emissão de pseudópodes. </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf9" class="pf w1 h8" data-page-no="9"><div class="pc pc9 w1 h8"><img fetchpriority="low" loading="lazy" class="bi x16 y19 w6 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bg9.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">6 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 xd h12 y5b ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Secreção: </span></div><div class="t m0 xf h12 yae ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Grânulos <span class="blank _5"></span>alfa: <span class="blank _14"></span>FI, <span class="blank _5"></span>FvW, <span class="blank _14"></span>trombospondina <span class="blank _14"></span>(proteína a<span class="blank _5"></span>desiva), <span class="blank _14"></span>PDGF, </span></div><div class="t m0 x10 h12 yaf ffa fs7 fc1 sc0 ls7 wsc">PF<span class="ls0 ws1">-4, P-selectina. </span></div><div class="t m0 xf h12 yb0 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Grânulos <span class="blank _16"> </span>densos: <span class="blank _16"> </span>serotonina <span class="blank _16"> </span>(vasoconstrição; <span class="blank _16"> </span>recruta <span class="blank _16"> </span>mais<span class="blank _5"></span> </span></div><div class="t m0 x10 h12 yb1 ffa fs7 fc1 sc0 ls0 ws1">plaquetas), <span class="blank _a"> </span>Ca,<span class="blank _3"> </span> <span class="blank _a"> </span>ADP <span class="blank _0"> </span>(ECAM-1; <span class="blank _0"> </span>recruta <span class="blank _a"> </span>mais <span class="blank _0"> </span>plaquetas), <span class="blank _a"> </span>ATP <span class="blank _a"> </span>e </div><div class="t m0 x10 h12 yb2 ffa fs7 fc1 sc0 ls0 wsd">histamin<span class="ls6 wse">a.</span><span class="ws1"> </span></div><div class="t m0 xd h12 yb3 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Atividade pró-coagulante: </span></div><div class="t m0 xf h12 yb4 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Exposição de fosfolipídios de membrana. </span></div><div class="t m0 xf h12 yb5 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Ca e FVIIIa <span class="ffd wsa">\u2192</span> enzimas para coagulação. </span></div><div class="t m0 x11 h12 yb6 ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>+ <span class="blank _2"> </span>fator <span class="blank _2"> </span>tecidual <span class="blank _2"> </span>+<span class="blank _5"></span> <span class="blank _2"> </span>FVIIIa <span class="blank _3"> </span>+ <span class="blank _2"> </span>fosfolipídios <span class="blank _2"> </span><span class="ffd wsa">\u2192</span> <span class="blank _2"> </span>complexo <span class="blank _2"> </span>tenase </span></div><div class="t m0 x12 h12 yb7 ffa fs7 fc1 sc0 ls0 ws1">extrínseco <span class="ffd ls1">\u2192</span> ativa FXa. </div><div class="t m0 xf h12 yb8 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Pró-trombinase: FXa + Ca + FVa. </span></div><div class="t m0 x7 h12 yb9 ffa fs7 fc1 sc0 ls0 ws1">Avaliação: </div><div class="t m0 xd h12 yba ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Clínica: </span></div><div class="t m0 xf h12 ybb ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Sangramento mucocutâneo. </span></div><div class="t m0 x11 h12 ybc ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Gengivorragia, equimose. </span></div><div class="t m0 x11 h12 ybd ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Não para de sangrar. </span></div><div class="t m0 x11 h12 ybe ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Fácil controle por compressão mecânica. </span></div><div class="t m0 xd h12 ybf ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Laboratório: </span></div><div class="t m0 xf h12 yc0 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Plaquetometria <span class="ffd ls1">\u2192</span> quantitativo. </span></div><div class="t m0 xf h12 yc1 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Tempo de sangramento <span class="ffd ls1">\u2192</span> qualitativo (função). </span></div><div class="t m0 x7 h12 yc2 ffa fs7 fc1 sc0 ls0 ws1">Secundária: </div><div class="t m0 x1c h12 yc3 ffa fs7 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 h12 yc4 ffa fs7 fc1 sc0 ls0 ws1">Fatores da coagulação: </div><div class="t m0 xd h12 yc5 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FI: </span></div><div class="t m0 xf h12 yc6 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fibrinogênio <span class="blank _0"> </span><span class="ffd wsa">\u2192<span class="blank _5"></span><span class="ffa ws1"> <span class="blank _a"> </span>produzido <span class="blank _a"> </span>pelo <span class="blank _a"> </span>fí<span class="blank _3"> </span>gado <span class="blank _a"> </span>(produz <span class="blank _a"> </span>todos) <span class="blank _a"> </span>e <span class="blank _a"> </span>sistema </span></span></span></div><div class="t m0 x10 h12 yc7 ffa fs7 fc1 sc0 ls0 ws1">retículoendotelial. </div><div class="t m0 xd h12 yc8 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FII: </span></div><div class="t m0 xf h12 yc9 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Protrombina. </span></div><div class="t m0 xd h12 yca ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FIII: </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pfa" class="pf w1 h8" data-page-no="a"><div class="pc pca w1 h8"><img fetchpriority="low" loading="lazy" class="bi x16 y19 w6 h13" alt="" src="https://files.passeidireto.com/a81f15b3-e0eb-434b-8fca-56802d96cabc/bga.png"><div class="c x0 y0 w2 h8"><div class="t m0 x7 ha y1a ff7 fs6 fc1 sc0 ls0 ws1"> </div><div class="t m0 x7 ha y1b ff7 fs6 fc1 sc0 ls0 ws1"> </div></div><div class="c x8 y1c w3 hb"><div class="t m0 x9 ha y1d ff7 fs6 fc0 sc0 ls0 ws1">7 </div></div><div class="c x7 y1e w4 hc"><div class="t m0 xa hd y1f ff8 fs7 fc1 sc0 ls0 ws1">Gustavo Urzêda Vitória </div></div><div class="c x0 y0 w2 h8"><div class="t m0 xf h12 y30 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Tromboplastina <span class="ffd ls1">\u2192</span> plaquetas também produzem. </span></div><div class="t m0 xd h12 ycb ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FIV: </span></div><div class="t m0 xf h12 yaf ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Cálcio <span class="ffd ls1">\u2192</span> presente em vários tecidos. </span></div><div class="t m0 xd h12 ycc ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FV: </span></div><div class="t m0 xf h12 ycd ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator lábil/pró-acelerina. </span></div><div class="t m0 xd h12 y60 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FVI: </span></div><div class="t m0 xf h12 y61 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Pró-fator V <span class="ffd ls1">\u2192</span> plaquetas. </span></div><div class="t m0 xd h12 yce ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FVI<span class="ls3 wsf">I:</span> </span></div><div class="t m0 xf h12 ycf ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator estável/pró-convertina. </span></div><div class="t m0 xd h12 yd0 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FVIII: </span></div><div class="t m0 xf h12 yd1 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator anti-hemofílico A <span class="ffd ls1">\u2192</span> células endoteliais. </span></div><div class="t m0 xd h12 yd2 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FIX: </span></div><div class="t m0 xf h12 yd3 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator anti-hemofílico B/Christmas. </span></div><div class="t m0 xd h12 yd4 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FX: </span></div><div class="t m0 xf h12 yd5 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Stuart. </span></div><div class="t m0 xd h12 yd6 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FXI: </span></div><div class="t m0 xf h12 yd7 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator anti-hemofílico C. </span></div><div class="t m0 xd h12 yd8 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FXII: </span></div><div class="t m0 xf h12 yd9 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator de Hagman. </span></div><div class="t m0 xd h12 yda ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>FXIII: </span></div><div class="t m0 xf h12 ydb ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Fator estabilizador de fibrina <span class="ffd ls2">\u2192</span> megacariócitos. </span></div><div class="t m0 xd h12 ydc ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Dependentes de vitamina K: </span></div><div class="t m0 xf h12 ydd ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ls8 ws1"> <span class="ls3">II, <span class="ls0">VII, XI, X. </span></span></span></div><div class="t m0 x11 h12 yde ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>VII tem a meia-vida menor. </span></div><div class="t m0 xf h12 ydf ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>PC e PS <span class="ffd ls1">\u2192</span> anticoagulantes. </span></div><div class="t m0 xf h12 ye0 ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Vitamina K <span class="ffd ls1">\u2192</span> carboxilação do zimogênio <span class="ffd ls1">\u2192</span> liga ao Ca. </span></div><div class="t m0 x7 h12 ye1 ffa fs7 fc1 sc0 ls0 ws1">Como avaliar: </div><div class="t m0 xd h12 ye2 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>TTPa <span class="ffd ls1">\u2192</span> via intrínseca (VIII, IX e XI). </span></div><div class="t m0 xd h12 ye3 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>TAP <span class="ffd ls1">\u2192</span> via extrínseca (VII). </span></div><div class="t m0 xd h12 ye4 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ls9 ws1"> <span class="lsa">TT <span class="ffd ls1">\u2192</span><span class="ls0"> via final (I). </span></span></span></div><div class="t m0 xd h12 ye5 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>TAP e TTPa normais e com sangramento: problema no FXIII. </span></div><div class="t m0 xd h12 ye6 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>TAP e TTPa alargados: intrínseca e extrínseca. </span></div><div class="t m0 x7 h14 ye7 ffa fsb fc1 sc0 ls0 ws1">Efeito final: </div><div class="t m0 xd h12 ye8 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Fibrina polimeriza por ação da trombina. </span></div><div class="t m0 xd h12 y7c ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>XIIIa promove as pontes cruzadas. </span></div><div class="t m0 xd h12 ye9 ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Começa <span class="blank _8"> </span>a <span class="blank _8"> </span>trombólise<span class="blank _5"></span> <span class="blank"> </span><span class="ffd ls1">\u2192</span> <span class="blank _0"> </span>quebra <span class="blank _8"> </span>a <span class="blank _8"> </span>rede <span class="blank _0"> </span>de <span class="blank"> </span>fibrina, <span class="blank _0"> </span>gera <span class="blank"> </span>prod<span class="blank _5"></span>utos <span class="blank _8"> </span>de </span></div><div class="t m0 xe h12 y7e ffa fs7 fc1 sc0 ls0 ws1">degradação da fibrina, como D-dímero. </div><div class="t m0 x7 h12 yea ffa fs7 fc1 sc0 ls0 ws1">Cascata da coagulação: </div><div class="t m0 xd h12 yeb ffb fs7 fc1 sc0 ls0 wsa">\u2022<span class="ffa ws1"> <span class="blank _4"> </span>Intrínseca: </span></div><div class="t m0 xf h12 yec ffc fs7 fc1 sc0 ls0 wsb">o<span class="ffa ws1"> <span class="blank _6"> </span>Cargas negativas vem do polifosfato inorgânico. </span></div><div class="t m0 x11 h12 yed ffd fs7 fc1 sc0 ls3">\u25aa<span class="ffa ls0 ws1"> <span class="blank _4"> </span>Liberado no humano por lesão tecidual. </span></div></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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