<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h0" alt="" src="https://files.passeidireto.com/a9eb0a0e-b32f-401e-a91b-8d0bbebff545/bg1.png"><div class="t m0 x1 h1 y1 ff1 fs0 fc0 sc0 ls0 ws0">24.08.2023</div><div class="t m0 x2 h2 y2 ff2 fs1 fc1 sc0 ls1 ws1">Imunidad\ue7c3<span class="blank"> </span>Inat\ue79d</div><div class="t m0 x1 h1 y3 ff1 fs0 fc0 sc0 ls1 ws2">Doença</div><div class="t m0 x3 h1 y4 ff1 fs0 fc0 sc0 ls1 ws3">-Quebra<span class="blank"> </span>da<span class="blank"> </span>homeostase</div><div class="t m0 x3 h1 y5 ff1 fs0 fc0 sc0 ls1 ws4">-Não<span class="blank"> </span>é<span class="blank"> </span>porque<span class="blank"> </span>a<span class="blank"> </span>pessoa<span class="blank"> </span>está<span class="blank"> </span>inf<span class="blank _0"></span>ectada<span class="blank"> </span>que<span class="blank"> </span>a<span class="blank"> </span>pesso<span class="blank _0"></span>a<span class="blank"> </span>está<span class="blank"> </span>doente.</div><div class="t m0 x1 h1 y6 ff1 fs0 fc0 sc0 ls1 ws2">Inata</div><div class="t m0 x3 h1 y7 ff1 fs0 fc0 sc0 ls1 ws5">-Primeira<span class="blank"> </span>linha<span class="blank"> </span>de<span class="blank"> </span>def<span class="blank _0"></span>esa,<span class="blank"> </span>o<span class="blank"> </span>indivíduo<span class="blank"> </span>saudáv<span class="blank _0"></span>el<span class="blank"> </span>nasce<span class="blank"> </span>imunocompetente.<span class="blank"> </span>Amamentaç<span class="blank _0"></span>ão:</div><div class="t m0 x1 h1 y8 ff1 fs0 fc0 sc0 ls1 ws6">transf<span class="blank _0"></span>erência<span class="blank"> </span>de<span class="blank"> </span>proteção<span class="blank _0"></span>,<span class="blank"> </span>imunização<span class="blank"> </span>passiv<span class="blank _0"></span>a.<span class="blank"> </span>Inespeci\ue99ecidade,<span class="blank"> </span>quando<span class="blank"> </span>não<span class="blank"> </span>é<span class="blank"> </span>do<span class="blank"> </span>corpo<span class="blank _0"></span>,<span class="blank"> </span>já</div><div class="t m0 x1 h1 y9 ff1 fs0 fc0 sc0 ls1 ws7">identi\ue99eca<span class="blank"> </span>c<span class="blank _0"></span>omo<span class="blank"> </span>ameaça,<span class="blank"> </span>é<span class="blank"> </span>rec<span class="blank _0"></span>onhecido<span class="blank"> </span>pelo<span class="blank"> </span>sinal<span class="blank"> </span>de<span class="blank"> </span>perigo<span class="blank _0"></span>,<span class="blank"> </span>pode<span class="blank"> </span>ser<span class="blank"> </span>perigoso.<span class="blank"> </span>O<span class="blank"> </span>neutró\ue99elo<span class="blank"> </span>é<span class="blank"> </span>a</div><div class="t m0 x1 h1 ya ff1 fs0 fc0 sc0 ls1 ws6">primeira<span class="blank"> </span>célula<span class="blank"> </span>de<span class="blank"> </span>def<span class="blank _0"></span>esa,<span class="blank"> </span>como<span class="blank"> </span>o<span class="blank"> </span>que<span class="blank"> </span>entra<span class="blank"> </span>no<span class="blank"> </span>c<span class="blank _0"></span>orpo<span class="blank"> </span>porta<span class="blank"> </span>alguma<span class="blank"> </span>estrutura<span class="blank"> </span>que<span class="blank"> </span>não<span class="blank"> </span>está<span class="blank"> </span>presente</div><div class="t m0 x1 h1 yb ff1 fs0 fc0 sc0 ls1 ws8">no<span class="blank"> </span>corpo<span class="blank _0"></span>,<span class="blank"> </span>é<span class="blank"> </span>rec<span class="blank _0"></span>onhecido<span class="blank"> </span>como<span class="blank"> </span>ameaç<span class="blank _0"></span>a.</div><div class="t m0 x3 h1 yc ff1 fs0 fc0 sc0 ls1 ws9">-Imediata,<span class="blank"> </span>c<span class="blank _0"></span>rônica.<span class="blank"> </span>Adquirida<span class="blank"> </span>atrav<span class="blank _0"></span>és<span class="blank"> </span>da<span class="blank"> </span>evo<span class="blank _0"></span>lução<span class="blank"> </span>da<span class="blank"> </span>espécie.</div><div class="t m0 x3 h1 yd ff1 fs0 fc0 sc0 ls1 wsa">-<span class="blank"> </span>A<span class="blank"> </span>resposta<span class="blank"> </span>adaptativa<span class="blank"> </span>deriv<span class="blank _0"></span>a<span class="blank"> </span>de<span class="blank"> </span>uma<span class="blank"> </span>resposta<span class="blank"> </span>inata,<span class="blank"> </span>e<span class="blank"> </span>para<span class="blank"> </span>que<span class="blank"> </span>oc<span class="blank _0"></span>orra,<span class="blank"> </span>demora<span class="blank"> </span>um<span class="blank"> </span>tempo.</div><div class="t m0 x1 h1 ye ff1 fs0 fc0 sc0 ls1 wsb">Só<span class="blank"> </span>é<span class="blank"> </span>ativada<span class="blank"> </span>quando<span class="blank"> </span>por<span class="blank"> </span>algum<span class="blank"> </span>motiv<span class="blank _0"></span>o<span class="blank"> </span>a<span class="blank"> </span>resposta<span class="blank"> </span>inata<span class="blank"> </span>não<span class="blank"> </span>é<span class="blank"> </span>su\ue99eciente<span class="blank"> </span>para<span class="blank"> </span>c<span class="blank _0"></span>ombater<span class="blank"> </span>o<span class="blank"> </span>p<span class="blank _0"></span>atógeno.</div><div class="t m0 x1 h1 yf ff1 fs0 fc0 sc0 ls1 ws2">Componentes</div><div class="t m0 x3 h1 y10 ff1 fs0 fc0 sc0 ls1 wsc">-Celulares:<span class="blank"> </span>neutró\ue99elos,<span class="blank"> </span>macrof<span class="blank _0"></span>agos,<span class="blank"> </span>celulas<span class="blank"> </span>dendritic<span class="blank _0"></span>as,<span class="blank"> </span>células<span class="blank"> </span>natural<span class="blank"> </span>killer.</div><div class="t m0 x3 h1 y11 ff1 fs0 fc0 sc0 ls1 wsd">-Humorais:<span class="blank"> </span>proteínas<span class="blank"> </span>solúv<span class="blank _0"></span>eis<span class="blank"> </span>do<span class="blank"> </span>plasma<span class="blank"> </span>sanguíneo<span class="blank _0"></span>,<span class="blank"> </span>que<span class="blank"> </span>são<span class="blank"> </span>as<span class="blank"> </span>proteínas<span class="blank"> </span>do<span class="blank"> </span>sistema</div><div class="t m0 x1 h1 y12 ff1 fs0 fc0 sc0 ls1 wse">comp<span class="blank _0"></span>lemento<span class="blank"> </span>e<span class="blank"> </span>cascata<span class="blank"> </span>de<span class="blank"> </span>c<span class="blank _0"></span>oagulaç<span class="blank _0"></span>ão,<span class="blank"> </span>citocinas<span class="blank"> </span>e<span class="blank"> </span>quimiocinas.<span class="blank"> </span>Citocinas<span class="blank"> </span>são<span class="blank"> </span>proteínas<span class="blank"> </span>que</div><div class="t m0 x1 h1 y13 ff1 fs0 fc0 sc0 ls1 wsf">medeiam<span class="blank"> </span>respostas<span class="blank"> </span>c<span class="blank _0"></span>elulares<span class="blank"> </span>como<span class="blank"> </span>ativaç<span class="blank _0"></span>ão,<span class="blank"> </span>inibiç<span class="blank _0"></span>ão,<span class="blank"> </span>dif<span class="blank _0"></span>erenciação<span class="blank"> </span>e<span class="blank"> </span>crescimento<span class="blank _0"></span>.</div><div class="t m0 x3 h1 y14 ff1 fs0 fc0 sc0 ls1 ws10">-F<span class="blank _0"></span>ebre:<span class="blank"> </span>tentativa<span class="blank"> </span>de<span class="blank"> </span>matar<span class="blank"> </span>o<span class="blank"> </span>patógeno<span class="blank _0"></span>,<span class="blank"> </span>mas<span class="blank"> </span>pode<span class="blank"> </span>causar</div><div class="t m0 x3 h1 y15 ff1 fs0 fc0 sc0 ls1 ws11">-Fígado:<span class="blank"> </span>produz<span class="blank"> </span>proteínas<span class="blank"> </span>de<span class="blank"> </span>comp<span class="blank _0"></span>lemento<span class="blank"> </span>e<span class="blank"> </span>a<span class="blank"> </span>cascata<span class="blank"> </span>de<span class="blank"> </span>c<span class="blank _0"></span>oagulaç<span class="blank _0"></span>ão.<span class="blank"> </span>Está<span class="blank"> </span>en<span class="blank _0"></span>vo<span class="blank _0"></span>lvido<span class="blank"> </span>com<span class="blank"> </span>a</div><div class="t m0 x1 h1 y16 ff1 fs0 fc0 sc0 ls1 ws12">hematopoiese<span class="blank"> </span>na<span class="blank"> </span>vida<span class="blank"> </span>intrauterina<span class="blank"> </span>e<span class="blank"> </span>extrauterina.<span class="blank"> </span>O<span class="blank"> </span>te<span class="blank _0"></span>cido<span class="blank"> </span>sofre<span class="blank"> </span>uma<span class="blank"> </span>injúria<span class="blank"> </span>e<span class="blank"> </span>a<span class="blank"> </span>célula<span class="blank"> </span>morre<span class="blank"> </span>por</div><div class="t m0 x1 h1 y17 ff1 fs0 fc0 sc0 ls1 ws13">nec<span class="blank _0"></span>rose,<span class="blank"> </span>os<span class="blank"> </span>anticorpos<span class="blank"> </span>correm<span class="blank"> </span>pela<span class="blank"> </span>v<span class="blank _0"></span>eia,<span class="blank"> </span>porque<span class="blank"> </span>o<span class="blank"> </span>\ue99fux<span class="blank _0"></span>o<span class="blank"> </span>de<span class="blank"> </span>sangue<span class="blank"> </span>na<span class="blank"> </span>artéria<span class="blank"> </span>é<span class="blank"> </span>muito<span class="blank"> </span>forte,<span class="blank"> </span>além<span class="blank"> </span>de</div><div class="t m0 x1 h1 y18 ff1 fs0 fc0 sc0 ls1 wse">possuir<span class="blank"> </span>uma<span class="blank"> </span>camada<span class="blank"> </span>muito<span class="blank"> </span>espessa,<span class="blank"> </span>protegendo-as.</div><div class="t m0 x3 h1 y19 ff1 fs0 fc0 sc0 ls1 ws14">-Qualquer<span class="blank"> </span>microorganismo<span class="blank"> </span>em<span class="blank"> </span>ambiente<span class="blank"> </span>e<span class="blank _0"></span>xtracelular<span class="blank"> </span>está<span class="blank"> </span>vulnerá<span class="blank _0"></span>vel<span class="blank"> </span>a<span class="blank"> </span>ação<span class="blank"> </span>da<span class="blank"> </span>resposta</div><div class="t m0 x1 h1 y1a ff1 fs0 fc0 sc0 ls1 ws15">imune<span class="blank"> </span>inata<span class="blank"> </span>atrav<span class="blank _0"></span>és<span class="blank"> </span>da<span class="blank"> </span>f<span class="blank _0"></span>agocitação.</div><div class="t m0 x3 h1 y1b ff1 fs0 fc0 sc0 ls1 ws7">-Em<span class="blank"> </span>ambiente<span class="blank"> </span>intracelular<span class="blank"> </span>as<span class="blank"> </span>c<span class="blank _0"></span>élulas<span class="blank"> </span>natural<span class="blank"> </span>killer<span class="blank"> </span>(NK)<span class="blank"> </span>e<span class="blank"> </span>interferons<span class="blank"> </span>(IFNs)<span class="blank"> </span>tipo<span class="blank"> </span>I</div><div class="t m0 x1 h1 y1c ff1 fs0 fc0 sc0 ls1 ws16">eliminam<span class="blank"> </span>agentes<span class="blank"> </span>inf<span class="blank _0"></span>ecciosos.<span class="blank"> </span>Amb<span class="blank _0"></span>as<span class="blank"> </span>fa<span class="blank _0"></span>zem<span class="blank"> </span>parte<span class="blank"> </span>da<span class="blank"> </span>resposta<span class="blank"> </span>imune<span class="blank"> </span>inata.<span class="blank"> </span>NK<span class="blank"> </span>mata<span class="blank"> </span>a<span class="blank"> </span>c<span class="blank _0"></span>élula<span class="blank"> </span>do</div><div class="t m0 x1 h1 y1d ff1 fs0 fc0 sc0 ls1 ws6">corpo<span class="blank"> </span>p<span class="blank _0"></span>ara<span class="blank"> </span>matar<span class="blank"> </span>a<span class="blank"> </span>célula<span class="blank"> </span>que<span class="blank"> </span>está<span class="blank"> </span>dentro<span class="blank"> </span>e<span class="blank"> </span>p<span class="blank _0"></span>ara<span class="blank"> </span>reduzir<span class="blank"> </span>o<span class="blank"> </span>dano<span class="blank _0"></span>,<span class="blank"> </span>é<span class="blank"> </span>morta<span class="blank"> </span>por<span class="blank"> </span>apoptose.<span class="blank"> </span>Receptores</div><div class="t m0 x1 h1 y1e ff1 fs0 fc0 sc0 ls1 ws17">do<span class="blank"> </span>comp<span class="blank _0"></span>lex<span class="blank _0"></span>o<span class="blank"> </span>terminal<span class="blank"> </span>de<span class="blank"> </span>histocomp<span class="blank _0"></span>atibilidade<span class="blank"> </span>são<span class="blank"> </span>responsáv<span class="blank _0"></span>eis<span class="blank"> </span>pela<span class="blank"> </span>rejeição<span class="blank"> </span>do<span class="blank"> </span>transplante,</div><div class="t m0 x1 h1 y1f ff1 fs0 fc0 sc0 ls1 ws9">expressão<span class="blank"> </span>do<span class="blank"> </span>MHC,<span class="blank"> </span>onde<span class="blank"> </span>é<span class="blank"> </span>perc<span class="blank _0"></span>ebida<span class="blank"> </span>a<span class="blank"> </span>alteração<span class="blank"> </span>pelo<span class="blank"> </span>NK,<span class="blank"> </span>se<span class="blank"> </span>a<span class="blank"> </span>c<span class="blank _0"></span>élula<span class="blank"> </span>tem<span class="blank"> </span>a<span class="blank"> </span>expressão<span class="blank"> </span>de<span class="blank"> </span>MHC</div><div class="t m0 x1 h1 y20 ff1 fs0 fc0 sc0 ls1 ws4">inativada,<span class="blank"> </span>oc<span class="blank _0"></span>orre<span class="blank"> </span>a<span class="blank"> </span>destruição<span class="blank _0"></span>.<span class="blank"> </span>T<span class="blank _1"></span>oda<span class="blank"> </span>célula<span class="blank"> </span>tem<span class="blank"> </span>MHC<span class="blank"> </span>classe<span class="blank"> </span>1.</div><div class="t m0 x1 h1 y21 ff1 fs0 fc0 sc0 ls1 ws15">Etap<span class="blank _0"></span>as<span class="blank"> </span>de<span class="blank"> </span>migração<span class="blank"> </span>transendotelial</div><div class="t m0 x3 h1 y22 ff1 fs0 fc0 sc0 ls1 ws2">-Rolamento</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w1 h0" alt="" src="https://files.passeidireto.com/a9eb0a0e-b32f-401e-a91b-8d0bbebff545/bg2.png"><div class="t m0 x3 h1 y1 ff1 fs0 fc0 sc0 ls1 ws2">-Ativaç<span class="blank _0"></span>ão</div><div class="t m0 x3 h1 y23 ff1 fs0 fc0 sc0 ls1 ws2">-Adesão</div><div class="t m0 x3 h1 y24 ff1 fs0 fc0 sc0 ls1 ws18">-Diapedese:<span class="blank"> </span>Migraç<span class="blank _0"></span>ão<span class="blank"> </span>transendotelial</div><div class="t m0 x1 h1 y25 ff1 fs0 fc0 sc0 ls1 wsb">Ativaç<span class="blank _0"></span>ão<span class="blank"> </span>da<span class="blank"> </span>resposta<span class="blank"> </span>imune<span class="blank"> </span>inata</div><div class="t m0 x3 h1 y26 ff1 fs0 fc0 sc0 ls1 ws19">-<span class="blank _0"></span>T<span class="blank _2"></span>ambém<span class="blank"> </span>rec<span class="blank _0"></span>onhece<span class="blank"> </span>mo<span class="blank _0"></span>léculas<span class="blank"> </span>próprias<span class="blank"> </span>do<span class="blank"> </span>organismo<span class="blank"> </span>que<span class="blank"> </span>são<span class="blank"> </span>liberadas<span class="blank"> </span>quando<span class="blank"> </span>ocorre<span class="blank"> </span>a</div><div class="t m0 x1 h1 y27 ff1 fs0 fc0 sc0 ls1 ws1a">morte<span class="blank"> </span>celular<span class="blank"> </span>por<span class="blank"> </span>ne<span class="blank _0"></span>crose.<span class="blank"> </span>P<span class="blank _1"></span>AMPS,<span class="blank"> </span>padrões<span class="blank"> </span>mo<span class="blank _0"></span>leculares<span class="blank"> </span>associados<span class="blank"> </span>aos<span class="blank"> </span>patógenos,<span class="blank"> </span>V<span class="blank _3"></span>AMPS,</div><div class="t m0 x1 h1 y28 ff1 fs0 fc0 sc0 ls1 wsc">padrões<span class="blank"> </span>mo<span class="blank _0"></span>leculares<span class="blank"> </span>associados<span class="blank"> </span>a<span class="blank"> </span>v<span class="blank _0"></span>enenos<span class="blank"> </span>e<span class="blank"> </span>DAMPS<span class="blank"> </span>p<span class="blank _0"></span>adrões<span class="blank"> </span>moleculares<span class="blank"> </span>associados<span class="blank"> </span>ao<span class="blank"> </span>dano<span class="blank _0"></span>.</div><div class="t m0 x1 h1 y29 ff1 fs0 fc0 sc0 ls1 ws11">Rec<span class="blank _0"></span>eptores<span class="blank"> </span>de<span class="blank"> </span>reconhe<span class="blank _0"></span>cimento<span class="blank"> </span>de<span class="blank"> </span>padrões<span class="blank"> </span>(PRR)</div><div class="t m0 x3 h1 y2a ff1 fs0 fc0 sc0 ls1 ws1b">-Estão<span class="blank"> </span>localizados</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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