<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/c12da339-4c8c-4b78-9cf3-93a54dd8ee93/bg1.png"><div class="c x1 y1 w2 h2"><div class="t m0 x2 h3 y2 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y3 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x4 h4 y5 ff1 fs1 fc0 sc0 ls1 ws1">LETÍ<span class="_0 blank"> </span>CIA <span class="_0 blank"> </span>SANTOS GARCIA<span class="_0 blank"> </span> </div><div class="t m0 x3 h3 y6 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y7 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y8 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y9 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 ya ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 yb ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 yc ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 yd ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 ye ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x5 h5 yf ff1 fs2 fc0 sc0 ls1 ws1">ESTUDOS D<span class="_1 blank"></span>E POTENCIA<span class="_1 blank"></span>I<span class="_0 blank"> </span>S INI<span class="_2 blank"></span>BID<span class="_1 blank"></span>ORES DA </div><div class="t m0 x6 h5 y10 ff1 fs2 fc0 sc0 ls1 ws1">ENZIM<span class="_1 blank"></span>A T<span class="_0 blank"> </span>IROSIN<span class="_1 blank"></span>A QUINASE D<span class="_1 blank"></span>E<span class="_0 blank"> </span> BRU<span class="_1 blank"></span>T<span class="_0 blank"> </span>ON <span class="ff2"> </span></div><div class="t m0 x7 h6 y11 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y12 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y13 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y14 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y15 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y16 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y17 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y18 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y19 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y1a ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y1b ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y1c ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y1d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y1e ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y1f ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y20 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x8 h4 y21 ff1 fs1 fc0 sc0 ls1 ws1">LAVRAS <span class="_0 blank"> </span><span class="ff4 ls0">±</span> M<span class="_0 blank"> </span>G </div><div class="t m0 x9 h4 y22 ff1 fs1 fc0 sc0 ls1 ws0">2014<span class="fs3 ws1"> </span></div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 xa h3 y23 ff1 fs0 fc0 sc0 ls1 ws1">LETÍCIA SANTO<span class="_1 blank"></span>S GARCIA </div><div class="t m0 x3 h3 y24 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y25 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y26 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y27 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x5 h3 y28 ff1 fs0 fc0 sc0 ls1 ws1">ESTUDOS DE P<span class="_2 blank"></span>OTENCIAIS INI<span class="_2 blank"></span>BIDORES DA<span class="_2 blank"></span> ENZ<span class="_1 blank"></span>IMA <span class="_0 blank"> </span>TIROSINA </div><div class="t m0 xb h3 y29 ff1 fs0 fc0 sc0 ls1 ws1">QUINASE DE<span class="_1 blank"></span> <span class="_0 blank"> </span>BRUTON<span class="_2 blank"></span> </div><div class="t m0 x3 h3 y2a ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2b ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2c ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xc h6 y2d ff3 fs0 fc0 sc0 ls1 ws1">Disse<span class="_1 blank"></span>r<span class="_0 blank"> </span>ta<span class="_0 blank"> </span>ção <span class="_3 blank"> </span>apre<span class="_1 blank"></span>s<span class="_0 blank"> </span>entada <span class="_3 blank"> </span>à<span class="_0 blank"> </span> <span class="_3 blank"> </span>Unive<span class="_1 blank"></span>r<span class="_0 blank"> </span>sidade </div><div class="t m0 xc h6 y2e ff3 fs0 fc0 sc0 ls1 ws1">Fede<span class="_1 blank"></span>r<span class="_0 blank"> </span>al <span class="_4 blank"> </span>de<span class="_1 blank"></span> <span class="_4 blank"> </span>La<span class="_0 blank"> </span>vras, <span class="_4 blank"> </span>com<span class="_1 blank"></span>o <span class="_5 blank"> </span>par<span class="_0 blank"> </span>te<span class="_1 blank"></span> <span class="_4 blank"> </span>das </div><div class="t m0 xc h6 y2f ff3 fs0 fc0 sc0 ls1 ws1">e<span class="_1 blank"></span>x<span class="_0 blank"> </span>igências <span class="_6 blank"> </span>do <span class="_6 blank"> </span>Program<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_6 blank"> </span>de <span class="_6 blank"> </span>Pós-</div><div class="t m0 xc h6 y30 ff3 fs0 fc0 sc0 ls1 ws1">Graduação <span class="_7 blank"> </span>em<span class="_1 blank"></span> <span class="_8 blank"> </span>Ag<span class="_1 blank"></span>r<span class="_0 blank"> </span>oquímic<span class="_1 blank"></span>a<span class="_0 blank"> </span>,<span class="_0 blank"> </span> <span class="_7 blank"> </span>á<span class="_0 blank"> </span>rea <span class="_7 blank"> </span>de<span class="_1 blank"></span> </div><div class="t m0 xc h6 y31 ff3 fs0 fc0 sc0 ls1 ws1">concen<span class="_1 blank"></span>tr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção <span class="_9 blank"> </span>em<span class="_1 blank"></span> <span class="_a blank"> </span>Ag<span class="_1 blank"></span>r<span class="_0 blank"> </span>oquím<span class="_1 blank"></span>i<span class="_0 blank"> </span>ca, <span class="_b blank"> </span>para <span class="_9 blank"> </span>a </div><div class="t m0 xc h6 y32 ff3 fs0 fc0 sc0 ls1 ws1">obten<span class="_1 blank"></span>ção <span class="_0 blank"> </span>do título<span class="_1 blank"></span> <span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_0 blank"> </span>M<span class="_0 blank"> </span>e<span class="_1 blank"></span>st<span class="_0 blank"> </span>re.<span class="_0 blank"> </span> </div><div class="t m0 xc h6 y33 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xc h6 y34 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xc h6 y35 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xc h6 y36 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xd h6 y37 ff3 fs0 fc0 sc0 ls1 ws1">Orien<span class="_1 blank"></span>ta<span class="_0 blank"> </span>dora </div><div class="t m0 xe h6 y38 ff3 fs0 fc0 sc0 ls1 ws1">Dra. Elaine<span class="_1 blank"></span> F<span class="_0 blank"> </span>on<span class="_1 blank"></span>t<span class="_0 blank"> </span>es Ferrei<span class="_1 blank"></span>r<span class="_0 blank"> </span>a <span class="_0 blank"> </span>da Cun<span class="_1 blank"></span>ha<span class="_c blank"> </span> </div><div class="t m0 xc h6 y39 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y3a ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y3b ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y3c ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y3d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y3e ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xf h3 y3f ff1 fs0 fc0 sc0 ls1 ws1">LAVRAS - MG </div><div class="t m0 x10 h3 y40 ff1 fs0 fc0 sc0 ls1 ws1">2014 <span class="_d blank"> </span> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x7 y41 w3 h7" alt="" src="https://files.passeidireto.com/c12da339-4c8c-4b78-9cf3-93a54dd8ee93/bg3.png"><div class="c x1 y1 w2 h2"><div class="t m0 x3 h3 y23 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y24 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y25 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y26 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y27 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y28 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y29 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2a ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2b ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2c ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y42 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y43 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y44 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y45 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y46 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y47 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y48 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y49 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4a ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4b ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4c ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4d ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4e ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y4f ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y50 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y51 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y3f ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h3 y52 ff1 fs0 fc0 sc0 ls1 ws1"> <span class="_d blank"> </span> </div></div><div class="c x11 y53 w4 h8"><div class="t m0 x12 h3 y54 ff1 fs0 fc0 sc0 ls1 ws1">Ficha<span class="_1 blank"></span> C<span class="_0 blank"> </span>atalográfi<span class="_1 blank"></span>c<span class="_0 blank"> </span>a Elab<span class="_1 blank"></span>o<span class="_0 blank"> </span>rada pela Coor<span class="_1 blank"></span>denadoria de Produtos e </div><div class="t m0 x13 h9 y55 ff1 fs0 fc0 sc0 ls1 ws1">Servi<span class="_1 blank"></span>ços d<span class="_0 blank"> </span>a Bibl<span class="_1 blank"></span>io<span class="_0 blank"> </span>teca<span class="_1 blank"></span> <span class="_0 blank"> </span>U<span class="_0 blank"> </span>ni<span class="_1 blank"></span>ve<span class="_0 blank"> </span>rsitária<span class="_1 blank"></span> <span class="_0 blank"> </span>da UFLA<span class="ff3 fs3"> </span></div><div class="t m0 x14 h3 y56 ff1 fs0 fc0 sc0 ls1 ws1"> </div></div><div class="c x7 y57 w5 ha"><div class="t m0 x15 h6 y58 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x15 h6 y59 ff3 fs0 fc0 sc0 ls1 ws1">Garcia, Le<span class="_1 blank"></span>t<span class="_0 blank"> </span>ícia Santos. </div><div class="t m0 x15 h6 y5a ff3 fs0 fc0 sc0 ls1 ws1"> Estudo<span class="_1 blank"></span>s de potenciais inibido<span class="_1 blank"></span>r<span class="_0 blank"> </span>es da en<span class="_1 blank"></span>z<span class="_0 blank"> </span>im<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_0 blank"> </span>T<span class="_0 blank"> </span>irosin<span class="_1 blank"></span>a<span class="_0 blank"> </span> Quin<span class="_1 blank"></span>a<span class="_0 blank"> </span>s<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_0 blank"> </span>de </div><div class="t m0 x15 h6 y5b ff3 fs0 fc0 sc0 ls1 ws1">Bruton<span class="_1 blank"></span> /<span class="_0 blank"> </span> Letícia Santo<span class="_1 blank"></span>s Ga<span class="_0 blank"> </span>rcia. <span class="ff5 ws2">±</span> <span class="_0 blank"> </span>Lav<span class="_1 blank"></span>r<span class="_0 blank"> </span>as : U<span class="_1 blank"></span>F<span class="_0 blank"> </span>LA<span class="_2 blank"></span>, 20<span class="_0 blank"> </span>14. </div><div class="t m0 x16 h6 y5c ff3 fs0 fc0 sc0 ls1 ws1"> 100 p. : i<span class="_1 blank"></span>l. </div><div class="t m0 x16 h6 y5d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x16 h6 y5e ff3 fs0 fc0 sc0 ls1 ws1"> Disse<span class="_1 blank"></span>r<span class="_0 blank"> </span>tação (me<span class="_1 blank"></span>stra<span class="_0 blank"> </span>do<span class="_1 blank"></span>) <span class="_0 blank"> </span><span class="ff5 ws2">±</span> Universidade<span class="_1 blank"></span> F<span class="_0 blank"> </span>ederal de<span class="_1 blank"></span> <span class="_0 blank"> </span>Lavras, 2014<span class="_0 blank"> </span>. </div><div class="t m0 x16 h6 y5f ff3 fs0 fc0 sc0 ls1 ws1"> Orie<span class="_1 blank"></span>ntador: Elaine<span class="_1 blank"></span> <span class="_0 blank"> </span>Fontes Fe<span class="_1 blank"></span>r<span class="_0 blank"> </span>r<span class="_0 blank"> </span>ei<span class="_1 blank"></span>r<span class="_0 blank"> </span>a<span class="_0 blank"> </span> da Cun<span class="_1 blank"></span>ha<span class="_c blank"> </span>. </div><div class="t m0 x16 h6 y60 ff3 fs0 fc0 sc0 ls1 ws1"> Bibl<span class="_1 blank"></span>iografia. </div><div class="t m0 x16 h6 y61 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x16 h6 y62 ff3 fs0 fc0 sc0 ls1 ws1"> 1. Li<span class="_1 blank"></span>nfócito B. 2. T<span class="_0 blank"> </span>irosi<span class="_1 blank"></span>na Quinase<span class="_1 blank"></span> <span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_c blank"> </span>Bruton. 3.<span class="_0 blank"> </span> An<span class="_1 blank"></span>c<span class="_0 blank"> </span>oramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o </div><div class="t m0 x15 h6 y63 ff3 fs0 fc0 sc0 ls1 ws1">molec<span class="_1 blank"></span>u<span class="_0 blank"> </span>lar<span class="_0 blank"> </span>. 4. QSAR-4D<span class="_1 blank"></span> <span class="_0 blank"> </span>DR. I. Un<span class="_1 blank"></span>ive<span class="_2 blank"></span>rsida<span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_0 blank"> </span>Fede<span class="_1 blank"></span>r<span class="_0 blank"> </span>a<span class="_0 blank"> </span>l de<span class="_1 blank"></span> La<span class="_0 blank"> </span>vras. II. </div><div class="t m0 x15 h6 y64 ff3 fs0 fc0 sc0 ls1 ws1">Título<span class="_1 blank"></span>. <span class="_0 blank"> </span> </div><div class="t m0 x16 h6 y65 ff3 fs0 fc0 sc0 ls1 ws1"> <span class="_2 blank"></span> <span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_2 blank"></span> <span class="_0 blank"> </span> </div><div class="t m0 x16 h6 y66 ff3 fs0 fc0 sc0 ls1 ws1"> <span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_2 blank"></span> <span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_2 blank"></span> <span class="_0 blank"> </span>C<span class="_0 blank"> </span>DD <span class="ff5 ws2">±</span> 574.1925<span class="_1 blank"></span> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 xa h3 y23 ff1 fs0 fc0 sc0 ls1 ws1">LETÍCIA SANTO<span class="_1 blank"></span>S GARCIA </div><div class="t m0 x3 h3 y24 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y25 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y26 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y27 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x5 h3 y28 ff1 fs0 fc0 sc0 ls1 ws1">ESTUDOS DE P<span class="_2 blank"></span>OTENCIAIS INI<span class="_1 blank"></span>B<span class="_0 blank"> </span>IDORES DA<span class="_1 blank"></span> <span class="_0 blank"> </span>ENZ<span class="_1 blank"></span>I<span class="_0 blank"> </span>MA TIROSINA </div><div class="t m0 xb h3 y29 ff1 fs0 fc0 sc0 ls1 ws1">QUINASE DE<span class="_1 blank"></span> <span class="_0 blank"> </span>BRUTON<span class="_2 blank"></span> </div><div class="t m0 x3 h3 y2a ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2b ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h3 y2c ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xc h6 y2d ff3 fs0 fc0 sc0 ls1 ws1">Disse<span class="_1 blank"></span>r<span class="_0 blank"> </span>ta<span class="_0 blank"> </span>ção <span class="_3 blank"> </span>apre<span class="_1 blank"></span>s<span class="_0 blank"> </span>entada <span class="_3 blank"> </span>à<span class="_0 blank"> </span> <span class="_3 blank"> </span>Unive<span class="_1 blank"></span>r<span class="_0 blank"> </span>sidade </div><div class="t m0 xc h6 y2e ff3 fs0 fc0 sc0 ls1 ws1">Fede<span class="_1 blank"></span>r<span class="_0 blank"> </span>al <span class="_4 blank"> </span>de<span class="_1 blank"></span> <span class="_5 blank"> </span>La<span class="_c blank"> </span>vras, <span class="_4 blank"> </span>com<span class="_1 blank"></span>o <span class="_5 blank"> </span>par<span class="_0 blank"> </span>te <span class="_5 blank"> </span>das </div><div class="t m0 xc h6 y2f ff3 fs0 fc0 sc0 ls1 ws1">e<span class="_1 blank"></span>x<span class="_0 blank"> </span>igências <span class="_6 blank"> </span>do <span class="_6 blank"> </span>Program<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_6 blank"> </span>de <span class="_6 blank"> </span>Pós-</div><div class="t m0 xc h6 y30 ff3 fs0 fc0 sc0 ls1 ws1">Graduação <span class="_7 blank"> </span>em<span class="_1 blank"></span> <span class="_8 blank"> </span>Ag<span class="_1 blank"></span>r<span class="_0 blank"> </span>oquímic<span class="_1 blank"></span>a<span class="_0 blank"> </span>, <span class="_7 blank"> </span>á<span class="_0 blank"> </span>r<span class="_0 blank"> </span>e<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_7 blank"> </span>de </div><div class="t m0 xc h6 y31 ff3 fs0 fc0 sc0 ls1 ws1">concen<span class="_1 blank"></span>tr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção <span class="_9 blank"> </span>em<span class="_1 blank"></span> <span class="_b blank"> </span>Agroquím<span class="_1 blank"></span>ica<span class="_0 blank"> </span>, <span class="_b blank"> </span>para <span class="_9 blank"> </span>a </div><div class="t m0 xc h6 y32 ff3 fs0 fc0 sc0 ls1 ws1">obten<span class="_1 blank"></span>ção <span class="_0 blank"> </span>do título<span class="_1 blank"></span> <span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_0 blank"> </span>M<span class="_0 blank"> </span>e<span class="_1 blank"></span>st<span class="_0 blank"> </span>re.<span class="_0 blank"> </span> </div><div class="t m0 x3 h3 y46 ff1 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y34 ff3 fs0 fc0 sc0 ls1 ws1">A<span class="_1 blank"></span>P<span class="_0 blank"> </span>ROVADA em<span class="_1 blank"></span> <span class="_0 blank"> </span>27 de feve<span class="_2 blank"></span>r<span class="_0 blank"> </span>eiro de<span class="_1 blank"></span> 2014.<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y35 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y36 ff3 fs0 fc0 sc0 ls1 ws1">Dra. Daiana Te<span class="_1 blank"></span>ixeira <span class="_0 blank"> </span>Man<span class="_1 blank"></span>cini <span class="_0 blank"> </span> <span class="_0 blank"> </span>U<span class="_1 blank"></span>F<span class="_0 blank"> </span>LA<span class="_1 blank"></span> </div><div class="t m0 x7 h6 y37 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y38 ff3 fs0 fc0 sc0 ls1 ws1">Dra. Me<span class="_1 blank"></span>lissa <span class="_0 blank"> </span>Soares Cae<span class="_1 blank"></span>ta<span class="_0 blank"> </span>no<span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_0 blank"> </span> UFOP </div><div class="t m0 x7 h6 y39 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y3a ff3 fs0 fc0 sc0 ls1 ws1">Dr. Teo<span class="_1 blank"></span>doric<span class="_0 blank"> </span>o de<span class="_1 blank"></span> <span class="_0 blank"> </span>Ca<span class="_0 blank"> </span>stro Ram<span class="_1 blank"></span>a<span class="_0 blank"> </span>lho<span class="_1 blank"></span> <span class="_0 blank"> </span> <span class="_0 blank"> </span> UFLA </div><div class="t m0 x17 h6 y3b ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xe h6 y67 ff3 fs0 fc0 sc0 ls1 ws1">Dra. Elaine<span class="_1 blank"></span> F<span class="_0 blank"> </span>on<span class="_1 blank"></span>t<span class="_0 blank"> </span>es Ferrei<span class="_1 blank"></span>r<span class="_0 blank"> </span>a <span class="_0 blank"> </span>da Cun<span class="_1 blank"></span>ha <span class="_0 blank"> </span> </div><div class="t m0 xd h6 y68 ff3 fs0 fc0 sc0 ls1 ws1">Orien<span class="_1 blank"></span>ta<span class="_0 blank"> </span>dora </div><div class="t m0 x3 h6 y69 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x3 h6 y6a ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 xf h3 y6b ff1 fs0 fc0 sc0 ls1 ws1">LAVRAS - MG </div><div class="t m0 x10 h3 y6c ff1 fs0 fc0 sc0 ls1">2014</div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x18 h3 y23 ff1 fs0 fc0 sc0 ls1 ws3">AGRADECIMENTO<span class="_1 blank"></span>S<span class="ff3 ws1"> </span></div><div class="t m0 x19 h6 y6d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x19 h6 y6e ff3 fs0 fc0 sc0 ls1 ws1">A<span class="_1 blank"></span> <span class="_e blank"> </span>DEUS, <span class="_e blank"> </span>se<span class="_2 blank"></span>nho<span class="_1 blank"></span>r <span class="_e blank"> </span>de<span class="_1 blank"></span> <span class="_e blank"> </span>t<span class="_0 blank"> </span>odas <span class="_c blank"> </span>a<span class="_0 blank"> </span>s <span class="_e blank"> </span>co<span class="_1 blank"></span>isas,<span class="_0 blank"> </span> <span class="_e blank"> </span>q<span class="_1 blank"></span>ue<span class="_1 blank"></span> <span class="_e blank"> </span>me<span class="_1 blank"></span> <span class="_e blank"> </span>per<span class="_0 blank"> </span>mi<span class="_1 blank"></span>t<span class="_0 blank"> </span>iu <span class="_f blank"> </span>a <span class="_f blank"> </span>conc<span class="_1 blank"></span>lusão <span class="_f blank"> </span>desta </div><div class="t m0 x7 h6 y6f ff3 fs0 fc0 sc0 ls1 ws1">e<span class="_1 blank"></span>ta<span class="_0 blank"> </span>pa <span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_0 blank"> </span>minh<span class="_1 blank"></span>a<span class="_0 blank"> </span> vid<span class="_2 blank"></span>a.<span class="_0 blank"> </span> </div><div class="t m0 x19 h6 y70 ff3 fs0 fc0 sc0 ls1 ws1">Ao<span class="_1 blank"></span>s <span class="_f blank"> </span>me<span class="_2 blank"></span>us <span class="_0 blank"> </span>pais, <span class="_c blank"> </span>Déi<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_c blank"> </span>e Gaspa<span class="_0 blank"> </span>r,<span class="_0 blank"> </span> <span class="_0 blank"> </span>por <span class="_0 blank"> </span>serem<span class="_1 blank"></span> <span class="_c blank"> </span>a <span class="_f blank"> </span>luz<span class="_1 blank"></span> <span class="_f blank"> </span>d<span class="_2 blank"></span>a <span class="_c blank"> </span>minha <span class="_c blank"> </span>e<span class="_1 blank"></span>str<span class="_0 blank"> </span>a<span class="_0 blank"> </span>da e <span class="_0 blank"> </span>meus </div><div class="t m0 x7 h6 y71 ff3 fs0 fc0 sc0 ls1 ws1">pil<span class="_1 blank"></span>a<span class="_0 blank"> </span>res de seg<span class="_1 blank"></span>ur<span class="_0 blank"> </span>ança em<span class="_1 blank"></span> tu<span class="_0 blank"> </span>do que<span class="_1 blank"></span> <span class="_0 blank"> </span>faço. P<span class="_0 blank"> </span>or e<span class="_1 blank"></span>st<span class="_0 blank"> </span>arem<span class="_1 blank"></span> s<span class="_0 blank"> </span>empre<span class="_1 blank"></span> <span class="_0 blank"> </span>comigo,<span class="_0 blank"> </span> <span class="_0 blank"> </span>me<span class="_1 blank"></span>s<span class="_0 blank"> </span>mo<span class="_1 blank"></span> <span class="_0 blank"> </span>à </div><div class="t m0 x19 h6 y72 ff3 fs0 fc0 sc0 ls1 ws1"> di<span class="_1 blank"></span>st<span class="_0 blank"> </span>ância, <span class="_f blank"> </span>por <span class="_f blank"> </span>não<span class="_1 blank"></span> <span class="_e blank"> </span>me<span class="_1 blank"></span> <span class="_e blank"> </span>deixarem<span class="_1 blank"></span> <span class="_e blank"> </span>desanim<span class="_1 blank"></span>a<span class="_0 blank"> </span>r <span class="_f blank"> </span>durante<span class="_1 blank"></span> <span class="_f blank"> </span>a<span class="_0 blank"> </span> <span class="_f blank"> </span>caminhad<span class="_1 blank"></span>a<span class="_0 blank"> </span>, <span class="_f blank"> </span>e <span class="_c blank"> </span>p<span class="_0 blank"> </span>ela </div><div class="t m0 x7 h6 y73 ff3 fs0 fc0 sc0 ls1 ws1">certe<span class="_1 blank"></span>za <span class="_0 blank"> </span>de<span class="_1 blank"></span> <span class="_0 blank"> </span>s<span class="_0 blank"> </span>e<span class="_1 blank"></span>u <span class="_0 blank"> </span>car<span class="_0 blank"> </span>inho<span class="_1 blank"></span> incondicional. </div><div class="t m0 x19 h6 y74 ff3 fs0 fc0 sc0 ls1 ws1">À<span class="_1 blank"></span> <span class="_7 blank"> </span>minh<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_10 blank"> </span>a<span class="_0 blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>da <span class="_10 blank"> </span>e <span class="_10 blank"> </span>úni<span class="_2 blank"></span>ca <span class="_10 blank"> </span>ir<span class="_0 blank"> </span>m<span class="_1 blank"></span>ã<span class="_0 blank"> </span> <span class="_10 blank"> </span>Michelly<span class="_2 blank"></span>, <span class="_7 blank"> </span>e<span class="_1 blank"></span>x<span class="_0 blank"> </span>emplo <span class="_10 blank"> </span>de<span class="_1 blank"></span> <span class="_10 blank"> </span>a<span class="_0 blank"> </span>miz<span class="_1 blank"></span>a<span class="_c blank"> </span>de<span class="_2 blank"></span>, </div><div class="t m0 x7 h6 y75 ff3 fs0 fc0 sc0 ls1 ws1">com<span class="_1 blank"></span>pa<span class="_0 blank"> </span>nheirismo<span class="_1 blank"></span>, <span class="_0 blank"> </span>confianç<span class="_1 blank"></span>a<span class="_0 blank"> </span>, <span class="_0 blank"> </span>amo<span class="_1 blank"></span>r,<span class="_0 blank"> </span> carinho<span class="_1 blank"></span> <span class="_c blank"> </span>e<span class="_1 blank"></span> <span class="_0 blank"> </span>com<span class="_2 blank"></span>preensã<span class="_0 blank"> </span>o. </div><div class="t m0 x19 h6 y76 ff3 fs0 fc0 sc0 ls1 ws1">Ao<span class="_1 blank"></span> <span class="_f blank"> </span>me<span class="_1 blank"></span>u <span class="_c blank"> </span>namo<span class="_2 blank"></span>ra<span class="_0 blank"> </span>do Juliano, <span class="_0 blank"> </span>pelo a<span class="_c blank"> </span>mo<span class="_1 blank"></span>r,<span class="_c blank"> </span> <span class="_0 blank"> </span>paciên<span class="_1 blank"></span>c<span class="_0 blank"> </span>ia, <span class="_0 blank"> </span>carinho<span class="_1 blank"></span>,<span class="_0 blank"> </span> <span class="_0 blank"> </span>por <span class="_c blank"> </span>me<span class="_1 blank"></span> <span class="_0 blank"> </span>a<span class="_0 blank"> </span>poiar </div><div class="t m0 x7 h6 y77 ff3 fs0 fc0 sc0 ls1 ws1">sem<span class="_1 blank"></span>pr<span class="_0 blank"> </span>e e po<span class="_1 blank"></span>r<span class="_0 blank"> </span> fazer <span class="_0 blank"> </span>mi<span class="_1 blank"></span>nha vida mai<span class="_2 blank"></span>s f<span class="_0 blank"> </span>eliz<span class="_1 blank"></span>.<span class="_c blank"> </span> </div><div class="t m0 x19 h6 y78 ff3 fs0 fc0 sc0 ls1 ws1">A<span class="_1 blank"></span> <span class="_11 blank"> </span>t<span class="_0 blank"> </span>oda <span class="_11 blank"> </span>m<span class="_1 blank"></span>i<span class="_0 blank"> </span>nha <span class="_12 blank"> </span>fa<span class="_0 blank"> </span>m<span class="_1 blank"></span>ília, <span class="_11 blank"> </span>que<span class="_1 blank"></span> <span class="_11 blank"> </span>sempr<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_11 blank"> </span>t<span class="_0 blank"> </span>orceu <span class="_12 blank"> </span>par<span class="_0 blank"> </span>a <span class="_11 blank"> </span>que<span class="_1 blank"></span> <span class="_11 blank"> </span>e<span class="_1 blank"></span>ssa<span class="_0 blank"> </span> <span class="_11 blank"> </span>vi<span class="_1 blank"></span>t<span class="_0 blank"> </span>ória <span class="_12 blank"> </span>foss<span class="_0 blank"> </span>e </div><div class="t m0 x7 h6 y79 ff3 fs0 fc0 sc0 ls1 ws1">concre<span class="_1 blank"></span>t<span class="_0 blank"> </span>izad<span class="_2 blank"></span>a.<span class="_0 blank"> </span> </div><div class="t m0 x19 h6 y33 ff3 fs0 fc0 sc0 ls1 ws1"> À minh<span class="_1 blank"></span>a <span class="_0 blank"> </span>orien<span class="_1 blank"></span>ta<span class="_c blank"> </span>do<span class="_1 blank"></span>r<span class="_0 blank"> </span>a Elaine<span class="_1 blank"></span>,<span class="_0 blank"> </span> p<span class="_0 blank"> </span>ela oportun<span class="_1 blank"></span>i<span class="_0 blank"> </span>dade<span class="_1 blank"></span>, <span class="_c blank"> </span>p<span class="_0 blank"> </span>or seu constante<span class="_1 blank"></span> <span class="_0 blank"> </span>apoio<span class="_2 blank"></span>, </div><div class="t m0 x7 h6 y34 ff3 fs0 fc0 sc0 ls1 ws1">con<span class="_1 blank"></span>f<span class="_0 blank"> </span>iança, <span class="_0 blank"> </span>e<span class="_1 blank"></span>nsi<span class="_0 blank"> </span>namen<span class="_1 blank"></span>t<span class="_0 blank"> </span>os, pa<span class="_0 blank"> </span>ciê<span class="_1 blank"></span>ncia e pela a<span class="_0 blank"> </span>m<span class="_1 blank"></span>izade. </div><div class="t m0 x19 h6 y35 ff3 fs0 fc0 sc0 ls1 ws1">Ao<span class="_1 blank"></span>s <span class="_e blank"> </span>me<span class="_1 blank"></span>mbros <span class="_f blank"> </span>da <span class="_0 blank"> </span>ba<span class="_0 blank"> </span>nc<span class="_2 blank"></span>a, <span class="_f blank"> </span>Daiana, <span class="_c blank"> </span>Mel<span class="_1 blank"></span>issa <span class="_f blank"> </span>e <span class="_0 blank"> </span>T<span class="_0 blank"> </span>eodo<span class="_1 blank"></span>r<span class="_0 blank"> </span>ico, <span class="_0 blank"> </span>pela <span class="_c blank"> </span>disposiç<span class="_1 blank"></span>ã<span class="_c blank"> </span>o <span class="_c blank"> </span>e </div><div class="t m0 x7 h6 y36 ff3 fs0 fc0 sc0 ls1 ws1">pel<span class="_1 blank"></span>a<span class="_0 blank"> </span>s contribui<span class="_1 blank"></span>ç<span class="_0 blank"> </span>õe<span class="_2 blank"></span>s <span class="_0 blank"> </span>que com<span class="_1 blank"></span>p<span class="_0 blank"> </span>leme<span class="_1 blank"></span>nt<span class="_0 blank"> </span>ar<span class="_0 blank"> </span>ão o trabal<span class="_1 blank"></span>ho.<span class="_0 blank"> </span> </div><div class="t m0 x19 h6 y37 ff3 fs0 fc0 sc0 ls1 ws1">Ao<span class="_1 blank"></span>s <span class="_13 blank"> </span>companheiro<span class="_1 blank"></span>s <span class="_13 blank"> </span>do La<span class="_0 blank"> </span>boratório<span class="_1 blank"></span> <span class="_13 blank"> </span>de <span class="_13 blank"> </span>Quím<span class="_1 blank"></span>ica <span class="_13 blank"> </span>Computacio<span class="_1 blank"></span>na<span class="_0 blank"> </span>l p<span class="_0 blank"> </span>elo<span class="_1 blank"></span>s<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y38 ff3 fs0 fc0 sc0 ls1 ws1">en<span class="_1 blank"></span>s<span class="_0 blank"> </span>ina<span class="_0 blank"> </span>men<span class="_1 blank"></span>t<span class="_0 blank"> </span>os, in<span class="_1 blank"></span>c<span class="_0 blank"> </span>entivo <span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_0 blank"> </span>amiz<span class="_1 blank"></span>a<span class="_0 blank"> </span>de<span class="_2 blank"></span>.<span class="_0 blank"> </span> </div><div class="t m0 x19 h6 y39 ff3 fs0 fc0 sc0 ls1 ws1">Ao<span class="_1 blank"></span> C<span class="_0 blank"> </span>NPq, U<span class="_1 blank"></span>F<span class="_0 blank"> </span>L<span class="_0 blank"> </span>A<span class="_1 blank"></span> <span class="_13 blank"> </span>e<span class="_1 blank"></span> DQI, pelo supo<span class="_1 blank"></span>r<span class="_0 blank"> </span>t<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_13 blank"> </span>e<span class="_1 blank"></span> oportunidade<span class="_1 blank"></span> de realizar a </div><div class="t m0 x7 h6 y3a ff3 fs0 fc0 sc0 ls1 ws1">pe<span class="_1 blank"></span>s<span class="_0 blank"> </span>quisa. </div><div class="t m0 x7 h9 y7a ff3 fs3 fc0 sc0 ls2 ws1"> <span class="fs0 ls1"> </span></div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x1a h3 y23 ff1 fs0 fc0 sc0 ls1 ws3">RESUMO<span class="ff3 ws1"> </span></div><div class="t m0 x19 h6 y6d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x19 h6 y7b ff3 fs0 fc0 sc0 ls1 ws1">A<span class="_1 blank"></span> <span class="_12 blank"> </span>T<span class="_0 blank"> </span>iro<span class="_1 blank"></span>si<span class="_0 blank"> </span>na <span class="_12 blank"> </span>Q<span class="_1 blank"></span>ui<span class="_0 blank"> </span>nase<span class="_1 blank"></span> <span class="_12 blank"> </span>de <span class="_14 blank"> </span>Bruton <span class="_14 blank"> </span>(B<span class="_1 blank"></span>t<span class="_0 blank"> </span>k) <span class="_12 blank"> </span>é<span class="_1 blank"></span> <span class="_12 blank"> </span>uma <span class="_12 blank"> </span>enzim<span class="_1 blank"></span>a <span class="_11 blank"> </span>impo<span class="_1 blank"></span>rt<span class="_0 blank"> </span>ante <span class="_14 blank"> </span>para <span class="_12 blank"> </span>o<span class="_1 blank"></span> </div><div class="t m0 x7 h6 y7c ff3 fs0 fc0 sc0 ls1 ws1">de<span class="_1 blank"></span>s<span class="_0 blank"> </span>envolvimen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_14 blank"> </span>e <span class="_14 blank"> </span>d<span class="_1 blank"></span>i<span class="_0 blank"> </span>ferenci<span class="_1 blank"></span>a<span class="_0 blank"> </span>ção <span class="_14 blank"> </span>do<span class="_1 blank"></span>s <span class="_14 blank"> </span>linfócitos <span class="_14 blank"> </span>B<span class="_1 blank"></span>.<span class="_0 blank"> </span> <span class="_14 blank"> </span>A<span class="_1 blank"></span>lém <span class="_14 blank"> </span>di<span class="_1 blank"></span>ss<span class="_0 blank"> </span>o, <span class="_14 blank"> </span>a <span class="_14 blank"> </span>e<span class="_1 blank"></span>xpr<span class="_0 blank"> </span>e<span class="_1 blank"></span>ssã<span class="_0 blank"> </span>o <span class="_14 blank"> </span>d<span class="_1 blank"></span>a<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y7d ff3 fs0 fc0 sc0 ls1 ws1">Btk<span class="_1 blank"></span> <span class="_11 blank"> </span>é <span class="_12 blank"> </span>c<span class="_0 blank"> </span>onside<span class="_1 blank"></span>r<span class="_0 blank"> </span>a<span class="_0 blank"> </span>da <span class="_12 blank"> </span>com<span class="_1 blank"></span>o <span class="_11 blank"> </span>essencial <span class="_12 blank"> </span>para <span class="_11 blank"> </span>a <span class="_12 blank"> </span>pr<span class="_0 blank"> </span>oli<span class="_1 blank"></span>f<span class="_0 blank"> </span>eração<span class="_1 blank"></span> <span class="_11 blank"> </span>e <span class="_12 blank"> </span>sobr<span class="_0 blank"> </span>evivê<span class="_1 blank"></span>nc<span class="_0 blank"> </span>ia <span class="_12 blank"> </span>dessas </div><div class="t m0 x7 h6 y7e ff3 fs0 fc0 sc0 ls1 ws1">cél<span class="_1 blank"></span>u<span class="_0 blank"> </span>las. <span class="_c blank"> </span>A <span class="_c blank"> </span>inibição<span class="_1 blank"></span> <span class="_f blank"> </span>da <span class="_c blank"> </span>Btk <span class="_0 blank"> </span>t<span class="_0 blank"> </span>em<span class="_1 blank"></span> <span class="_c blank"> </span>s<span class="_0 blank"> </span>e <span class="_0 blank"> </span>t<span class="_0 blank"> </span>ornado<span class="_2 blank"></span> <span class="_c blank"> </span>u<span class="_0 blank"> </span>m<span class="_1 blank"></span> <span class="_c blank"> </span>a<span class="_0 blank"> </span>lvo <span class="_0 blank"> </span>a<span class="_0 blank"> </span>trativo<span class="_2 blank"></span> <span class="_c blank"> </span>par<span class="_0 blank"> </span>a <span class="_f blank"> </span>o <span class="_0 blank"> </span>tratamen<span class="_1 blank"></span>to <span class="_c blank"> </span>de </div><div class="t m0 x7 h6 y7f ff3 fs0 fc0 sc0 ls1 ws1">doen<span class="_1 blank"></span>ças <span class="_e blank"> </span>autoimune<span class="_1 blank"></span>s,<span class="_0 blank"> </span> <span class="_e blank"> </span>leucem<span class="_1 blank"></span>ias<span class="_0 blank"> </span> <span class="_e blank"> </span>e<span class="_1 blank"></span> <span class="_e blank"> </span>l<span class="_0 blank"> </span>infom<span class="_1 blank"></span>as <span class="_e blank"> </span>de <span class="_f blank"> </span>c<span class="_0 blank"> </span>él<span class="_1 blank"></span>u<span class="_0 blank"> </span>las <span class="_f blank"> </span>B.<span class="_0 blank"> </span> <span class="_f blank"> </span>Objetivando-se <span class="_f blank"> </span>propor </div><div class="t m0 x7 h6 y80 ff3 fs0 fc0 sc0 ls1 ws1">novos <span class="_f blank"> </span>candidatos <span class="_f blank"> </span>a <span class="_e blank"> </span>fá<span class="_0 blank"> </span>rmaco<span class="_1 blank"></span>s <span class="_14 blank"> </span>in<span class="_1 blank"></span>ibidore<span class="_1 blank"></span>s <span class="_14 blank"> </span>d<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_e blank"> </span>Btk, <span class="_e blank"> </span>técnicas <span class="_e blank"> </span>com<span class="_1 blank"></span>put<span class="_0 blank"> </span>ac<span class="_0 blank"> </span>ionais <span class="_f blank"> </span>f<span class="_0 blank"> </span>oram </div><div class="t m0 x7 h6 y81 ff3 fs0 fc0 sc0 ls1 ws1">aplic<span class="_1 blank"></span>a<span class="_0 blank"> </span>das <span class="_0 blank"> </span>ne<span class="_1 blank"></span>st<span class="_c blank"> </span>e <span class="_0 blank"> </span>e<span class="_1 blank"></span>studo. <span class="_0 blank"> </span>Foi <span class="_0 blank"> </span>realiz<span class="_2 blank"></span>a<span class="_0 blank"> </span>do um <span class="_0 blank"> </span>estudo de a<span class="_0 blank"> </span>nco<span class="_1 blank"></span>r<span class="_0 blank"> </span>amen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_0 blank"> </span>molec<span class="_1 blank"></span>u<span class="_0 blank"> </span>lar<span class="_0 blank"> </span> a<span class="_0 blank"> </span> fi<span class="_0 blank"> </span>m </div><div class="t m0 x7 h6 y82 ff3 fs0 fc0 sc0 ls1 ws1">de<span class="_1 blank"></span> <span class="_15 blank"> </span>avaliar <span class="_15 blank"> </span>o <span class="_3 blank"> </span>modo <span class="_3 blank"> </span>de <span class="_3 blank"> </span>interação <span class="_3 blank"> </span>de<span class="_1 blank"></span> <span class="_15 blank"> </span>96 <span class="_15 blank"> </span>inibidore<span class="_1 blank"></span>s<span class="_c blank"> </span> <span class="_15 blank"> </span>n<span class="_2 blank"></span>icotinamíd<span class="_2 blank"></span>icos <span class="_15 blank"> </span>d<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_15 blank"> </span>B<span class="_1 blank"></span>t<span class="_0 blank"> </span>k<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y83 ff3 fs0 fc0 sc0 ls1 ws1">(DELU<span class="_1 blank"></span>CC<span class="_0 blank"> </span>A <span class="_14 blank"> </span>e<span class="_1 blank"></span>t <span class="_14 blank"> </span>a<span class="_0 blank"> </span>l.,<span class="ff6 ls3"> </span>2010). <span class="_14 blank"> </span>Os <span class="_14 blank"> </span>v<span class="_1 blank"></span>alore<span class="_1 blank"></span>s <span class="_12 blank"> </span>do<span class="_1 blank"></span>s <span class="_14 blank"> </span>ter<span class="_0 blank"> </span>mo<span class="_1 blank"></span>s <span class="_14 blank"> </span>de <span class="_14 blank"> </span>ene<span class="_1 blank"></span>r<span class="_c blank"> </span>gi<span class="_1 blank"></span>a <span class="_14 blank"> </span>pa<span class="_0 blank"> </span>ra <span class="_14 blank"> </span>as <span class="_14 blank"> </span>m<span class="_1 blank"></span>elhore<span class="_1 blank"></span>s<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y84 ff3 fs0 fc0 sc0 ls1 ws1">con<span class="_1 blank"></span>f<span class="_0 blank"> </span>ormaçõe<span class="_1 blank"></span>s <span class="_11 blank"> </span>ancoradas <span class="_11 blank"> </span>mo<span class="_1 blank"></span>st<span class="_0 blank"> </span>rou <span class="_12 blank"> </span>u<span class="_0 blank"> </span>m<span class="_1 blank"></span> <span class="_12 blank"> </span>c<span class="_0 blank"> </span>oefi<span class="_1 blank"></span>c<span class="_0 blank"> </span>iente<span class="_2 blank"></span> <span class="_11 blank"> </span>de<span class="_1 blank"></span> de<span class="_1 blank"></span>ter<span class="_0 blank"> </span>min<span class="_1 blank"></span>a<span class="_0 blank"> </span>ção <span class="_12 blank"> </span>de <span class="_12 blank"> </span>0,80. <span class="_11 blank"> </span>A </div><div class="t m0 x7 h6 y85 ff3 fs0 fc0 sc0 ls1 ws1">me<span class="_1 blank"></span>t<span class="_0 blank"> </span>odologia <span class="_16 blank"> </span>de<span class="_1 blank"></span> <span class="_16 blank"> </span>QSAR-4D <span class="_e blank"> </span>DR <span class="_16 blank"> </span>t<span class="_0 blank"> </span>am<span class="_1 blank"></span>b<span class="_0 blank"> </span>ém<span class="_1 blank"></span> <span class="_16 blank"> </span>f<span class="_0 blank"> </span>oi <span class="_e blank"> </span>utilizada. <span class="_e blank"> </span>As <span class="_e blank"> </span>c<span class="_0 blank"> </span>onfo<span class="_1 blank"></span>r<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>ções <span class="_e blank"> </span>obtid<span class="_1 blank"></span>a<span class="_0 blank"> </span>s<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y86 ff3 fs0 fc0 sc0 ls1 ws1">por <span class="_0 blank"> </span>si<span class="_0 blank"> </span>m<span class="_1 blank"></span>u<span class="_0 blank"> </span>lação <span class="_c blank"> </span>da <span class="_f blank"> </span>dinâmic<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_f blank"> </span>mole<span class="_1 blank"></span>cu<span class="_0 blank"> </span>lar <span class="_c blank"> </span>foram<span class="_1 blank"></span> <span class="_f blank"> </span>s<span class="_0 blank"> </span>obrepostas, <span class="_c blank"> </span>de<span class="_1 blank"></span> <span class="_c blank"> </span>a<span class="_0 blank"> </span>cordo <span class="_c blank"> </span>c<span class="_0 blank"> </span>om <span class="_c blank"> </span>os <span class="_c blank"> </span>três </div><div class="t m0 x7 h6 y2d ff3 fs0 fc0 sc0 ls1 ws1">alinh<span class="_2 blank"></span>a<span class="_0 blank"> </span>men<span class="_1 blank"></span>t<span class="_0 blank"> </span>os te<span class="_1 blank"></span>st<span class="_0 blank"> </span>ados, em<span class="_1 blank"></span> u<span class="_0 blank"> </span>ma caixa vi<span class="_1 blank"></span>r<span class="_0 blank"> </span>tual tr<span class="_0 blank"> </span>id<span class="_1 blank"></span>imensional<span class="_1 blank"></span> <span class="_0 blank"> </span>composta por cél<span class="_1 blank"></span>ulas<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 y2e ff3 fs0 fc0 sc0 ls1 ws1">de<span class="_1 blank"></span> <span class="_12 blank"> </span>2 <span class="_12 blank"> </span>e <span class="_14 blank"> </span>5<span class="_0 blank"> </span>Å. <span class="_14 blank"> </span>Os <span class="_12 blank"> </span>modelo<span class="_1 blank"></span>s <span class="_12 blank"> </span>foram <span class="_14 blank"> </span>gera<span class="_0 blank"> </span>do<span class="_1 blank"></span>s <span class="_12 blank"> </span>pela <span class="_14 blank"> </span>t<span class="_0 blank"> </span>écnic<span class="_2 blank"></span>a <span class="_12 blank"> </span>com<span class="_1 blank"></span>b<span class="_0 blank"> </span>in<span class="_2 blank"></span>a<span class="_0 blank"> </span>da <span class="_14 blank"> </span>de <span class="_16 blank"> </span>a<span class="_0 blank"> </span>lgoritmos </div><div class="t m0 x7 h6 y2f ff3 fs0 fc0 sc0 ls1 ws1">gené<span class="_1 blank"></span>t<span class="_0 blank"> </span>icos (GA, do inglê<span class="_1 blank"></span>s<span class="_c blank"> </span><span class="ff6"> Genetic Algorithm</span>) e <span class="_13 blank"> </span>m<span class="_1 blank"></span>ínimos quadrado<span class="_1 blank"></span>s pa<span class="_0 blank"> </span>rciais </div><div class="t m0 x7 h6 y30 ff3 fs0 fc0 sc0 ls1 ws1">(PLS, <span class="_13 blank"> </span>d<span class="_1 blank"></span>o <span class="_13 blank"> </span>i<span class="_0 blank"> </span>ngê<span class="_1 blank"></span>s <span class="_3 blank"> </span><span class="ff6">P<span class="_2 blank"></span>artial <span class="_13 blank"> </span>Least <span class="_13 blank"> </span>Square<span class="ff3">). <span class="_13 blank"> </span>O <span class="_13 blank"> </span>me<span class="_1 blank"></span>lhor <span class="_13 blank"> </span>m<span class="_1 blank"></span>odelo <span class="_13 blank"> </span>gerou <span class="_13 blank"> </span>v<span class="_1 blank"></span>a<span class="_0 blank"> </span>lor<span class="_0 blank"> </span>e<span class="_1 blank"></span>s <span class="_13 blank"> </span>d<span class="_0 blank"> </span>e </span></span></div><div class="t m0 x7 hb y31 ff3 fs0 fc0 sc0 ls1 ws1">valid<span class="_1 blank"></span>a<span class="_0 blank"> </span>ção <span class="_0 blank"> </span>cr<span class="_0 blank"> </span>uzada <span class="_c blank"> </span>ajustado<span class="_1 blank"></span> <span class="_c blank"> </span>(<span class="_0 blank"> </span>q<span class="_0 blank"> </span><span class="fs4 ls4 v1">2</span><span class="fs4 ws4 v2">ajustado</span>) <span class="_c blank"> </span>e <span class="_c blank"> </span>coeficien<span class="_1 blank"></span>t<span class="_0 blank"> </span>e <span class="_c blank"> </span>de <span class="_f blank"> </span>determinação <span class="_0 blank"> </span>(R<span class="fs4 ls5 v1">2</span>) <span class="_f blank"> </span>de <span class="_0 blank"> </span>0,67 </div><div class="t m0 x7 h6 y32 ff3 fs0 fc0 sc0 ls1 ws1">e<span class="_1 blank"></span> <span class="_0 blank"> </span>0,74, <span class="_0 blank"> </span>respec<span class="_1 blank"></span>t<span class="_0 blank"> </span>i<span class="_0 blank"> </span>vamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>e. <span class="_0 blank"> </span>A análise do QS<span class="_0 blank"> </span>A<span class="_1 blank"></span>R<span class="_0 blank"> </span>-4D DR,<span class="_0 blank"> </span> além de corroborar<span class="_0 blank"> </span> com<span class="_1 blank"></span> <span class="_0 blank"> </span>os </div><div class="t m0 x7 h6 y87 ff3 fs0 fc0 sc0 ls1 ws1">resul<span class="_1 blank"></span>ta<span class="_0 blank"> </span>dos <span class="_10 blank"> </span>do<span class="_1 blank"></span> <span class="_10 blank"> </span><span class="ff6 ws5">docking</span>,<span class="_0 blank"> </span> <span class="_10 blank"> </span>suge<span class="_1 blank"></span>r<span class="_0 blank"> </span>iu <span class="_10 blank"> </span>um<span class="_1 blank"></span>a <span class="_10 blank"> </span>boa <span class="_10 blank"> </span>co<span class="_1 blank"></span>r<span class="_0 blank"> </span>relação <span class="_10 blank"> </span>com<span class="_1 blank"></span> <span class="_7 blank"> </span>os <span class="_a blank"> </span>r<span class="_0 blank"> </span>esultados </div><div class="t m0 x7 h6 y88 ff3 fs0 fc0 sc0 ls1 ws1">e<span class="_1 blank"></span>xp<span class="_0 blank"> </span>erime<span class="_1 blank"></span>nt<span class="_0 blank"> </span>ais <span class="_b blank"> </span>e<span class="_1 blank"></span>,<span class="_0 blank"> </span> <span class="_b blank"> </span>aind<span class="_1 blank"></span>a,<span class="_0 blank"> </span> <span class="_9 blank"> </span>fornece<span class="_2 blank"></span>u <span class="_b blank"> </span>info<span class="_1 blank"></span>r<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>çõe<span class="_1 blank"></span>s <span class="_b blank"> </span>m<span class="_1 blank"></span>a<span class="_c blank"> </span>is <span class="_b blank"> </span>de<span class="_1 blank"></span>talhadas <span class="_b blank"> </span>do<span class="_1 blank"></span> <span class="_b blank"> </span>q<span class="_1 blank"></span>u<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_b blank"> </span>o </div><div class="t m0 x7 h3 y89 ff3 fs0 fc0 sc0 ls1 ws1">ancoramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_16 blank"> </span>mole<span class="_1 blank"></span>cular<span class="_0 blank"> </span>. <span class="_16 blank"> </span>A <span class="_e blank"> </span>boa <span class="_e blank"> </span>p<span class="_0 blank"> </span>otênci<span class="_1 blank"></span>a <span class="_16 blank"> </span>pr<span class="_0 blank"> </span>edita <span class="_16 blank"> </span>para <span class="_f blank"> </span>o <span class="_e blank"> </span>c<span class="_0 blank"> </span>om<span class="_1 blank"></span>p<span class="_0 blank"> </span>osto <span class="_16 blank"> </span><span class="ff1 ws3">M2</span> <span class="_e blank"> </span>pr<span class="_0 blank"> </span>opo<span class="_1 blank"></span>st<span class="_0 blank"> </span>o </div><div class="t m0 x7 h6 y8a ff3 fs0 fc0 sc0 ls1 ws1">indic<span class="_2 blank"></span>a <span class="_0 blank"> </span>que<span class="_1 blank"></span> <span class="_0 blank"> </span>e<span class="_1 blank"></span>st<span class="_0 blank"> </span>e composto é um po<span class="_1 blank"></span>t<span class="_0 blank"> </span>encial<span class="_2 blank"></span> candidato a inibido<span class="_1 blank"></span>r<span class="_0 blank"> </span> da Btk. </div><div class="t m0 x19 h6 y8b ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x19 h6 y8c ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y8d ff3 fs0 fc0 sc0 ls1 ws1">Palavras-ch<span class="_1 blank"></span>a<span class="_0 blank"> </span>ve:<span class="_1 blank"></span> <span class="_10 blank"> </span>L<span class="_0 blank"> </span>infócito<span class="_1 blank"></span> <span class="_7 blank"> </span>B. <span class="_10 blank"> </span>Tirosi<span class="_1 blank"></span>na <span class="_10 blank"> </span>Quinase<span class="_1 blank"></span> <span class="_7 blank"> </span>de<span class="_1 blank"></span> <span class="_7 blank"> </span>Bruton<span class="_1 blank"></span>.<span class="_0 blank"> </span> <span class="_10 blank"> </span>Ancoramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o </div><div class="t m0 x7 h6 y8e ff3 fs0 fc0 sc0 ls1 ws1">molec<span class="_1 blank"></span>u<span class="_0 blank"> </span>lar. <span class="_0 blank"> </span>QSAR-4D<span class="_2 blank"></span> DR </div><div class="t m0 x7 h6 y8f ff3 fs0 fc0 sc0 ls1 ws1"> <span class="_d blank"> </span> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x1b h3 y90 ff1 fs0 fc0 sc0 ls1 ws1">ABSTRACT </div><div class="t m0 x19 h6 y91 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x19 h6 y92 ff5 fs0 fc0 sc0 ls1 ws6">%UXWRQ¶<span class="_1 blank"></span>V\ue003 7<span class="_0 blank"> </span>\URVLQH<span class="_1 blank"></span>\ue003<span class="_10 blank"> </span>.LQDVH\ue003 \ue00b%WN\ue00c\ue003 L<span class="_1 blank"></span>V\ue003 D<span class="_0 blank"> </span>Q\ue003 LPSRUWDQW\ue003 HQ]\PH<span class="_1 blank"></span>\ue003 L<span class="_0 blank"> </span>Q<span class="_2 blank"></span>\ue003 %<span class="_0 blank"> </span><span class="ff3">-</span></div><div class="t m0 x7 h6 y93 ff3 fs0 fc0 sc0 ls1 ws1">lym<span class="_1 blank"></span>p<span class="_0 blank"> </span>hocy<span class="_2 blank"></span>t<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_13 blank"> </span>deve<span class="_2 blank"></span>lopme<span class="_2 blank"></span>nt and diffe<span class="_1 blank"></span>r<span class="_c blank"> </span>en<span class="_2 blank"></span>t<span class="_0 blank"> </span>iation<span class="_1 blank"></span>. F<span class="_0 blank"> </span>urthe<span class="_1 blank"></span>r<span class="_c blank"> </span>mo<span class="_1 blank"></span>r<span class="_0 blank"> </span>e, Btk e<span class="_2 blank"></span>xpr<span class="_0 blank"> </span>ession<span class="_1 blank"></span> is </div><div class="t m0 x7 h6 y94 ff3 fs0 fc0 sc0 ls1 ws1">con<span class="_1 blank"></span>s<span class="_0 blank"> </span>ider<span class="_0 blank"> </span>e<span class="_1 blank"></span>d <span class="_15 blank"> </span>essential <span class="_3 blank"> </span>for <span class="_15 blank"> </span>the <span class="_3 blank"> </span>pr<span class="_0 blank"> </span>olife<span class="_1 blank"></span>r<span class="_0 blank"> </span>ati<span class="_0 blank"> </span>on <span class="_3 blank"> </span>and <span class="_15 blank"> </span>surviv<span class="_1 blank"></span>a<span class="_0 blank"> </span>l <span class="_15 blank"> </span>of <span class="_3 blank"> </span>t<span class="_0 blank"> </span>he<span class="_1 blank"></span>s<span class="_0 blank"> </span>e <span class="_15 blank"> </span>cells. <span class="_3 blank"> </span>Bt<span class="_0 blank"> </span>k </div><div class="t m0 x7 h6 y95 ff3 fs0 fc0 sc0 ls1 ws1">inhi<span class="_1 blank"></span>b<span class="_0 blank"> </span>ition <span class="_c blank"> </span>has <span class="_c blank"> </span>be<span class="_1 blank"></span>c<span class="_0 blank"> </span>ome <span class="_0 blank"> </span>a<span class="_0 blank"> </span>n<span class="_2 blank"></span> <span class="_c blank"> </span>att<span class="_0 blank"> </span>ractive<span class="_1 blank"></span> <span class="_c blank"> </span>ta<span class="_0 blank"> </span>rge<span class="_1 blank"></span>t <span class="_c blank"> </span>f<span class="_0 blank"> </span>or<span class="_0 blank"> </span> <span class="_c blank"> </span>tr<span class="_0 blank"> </span>e<span class="_1 blank"></span>a<span class="_0 blank"> </span>ting<span class="_1 blank"></span> <span class="_f blank"> </span>autoimm<span class="_1 blank"></span>u<span class="_0 blank"> </span>ne<span class="_1 blank"></span> <span class="_f blank"> </span>dis<span class="_0 blank"> </span>e<span class="_1 blank"></span>a<span class="_0 blank"> </span>s<span class="_0 blank"> </span>e<span class="_1 blank"></span>s,<span class="_0 blank"> </span> <span class="_c blank"> </span>a<span class="_0 blank"> </span>nd </div><div class="t m0 x7 h6 y96 ff3 fs0 fc0 sc0 ls1 ws1">B-cell<span class="_1 blank"></span> <span class="_a blank"> </span>leukemi<span class="_1 blank"></span>a <span class="_a blank"> </span>a<span class="_0 blank"> </span>nd <span class="_a blank"> </span>lym<span class="_1 blank"></span>p<span class="_0 blank"> </span>hom<span class="_1 blank"></span>a<span class="_0 blank"> </span>s. <span class="_a blank"> </span>With<span class="_1 blank"></span> <span class="_a blank"> </span>the <span class="_a blank"> </span>o<span class="_2 blank"></span>bj<span class="_0 blank"> </span>ective<span class="_1 blank"></span> <span class="_10 blank"> </span>o<span class="_1 blank"></span>f <span class="_b blank"> </span>pr<span class="_0 blank"> </span>oposing<span class="_1 blank"></span> <span class="_10 blank"> </span>ne<span class="_1 blank"></span>w </div><div class="t m0 x7 h6 y97 ff3 fs0 fc0 sc0 ls1 ws1">candid<span class="_1 blank"></span>at<span class="_0 blank"> </span>es <span class="_10 blank"> </span>for <span class="_10 blank"> </span>Btk<span class="_2 blank"></span> <span class="_7 blank"> </span>inhi<span class="_1 blank"></span>b<span class="_0 blank"> </span>itor <span class="_10 blank"> </span>pharm<span class="_1 blank"></span>a<span class="_0 blank"> </span>ceuticals, <span class="_10 blank"> </span>we <span class="_7 blank"> </span>applied<span class="_1 blank"></span> <span class="_7 blank"> </span>computation<span class="_1 blank"></span>al </div><div class="t m0 x7 h6 y98 ff3 fs0 fc0 sc0 ls1 ws1">te<span class="_1 blank"></span>c<span class="_0 blank"> </span>hniques <span class="_12 blank"> </span>in<span class="_1 blank"></span> <span class="_11 blank"> </span>t<span class="_0 blank"> </span>his <span class="_14 blank"> </span>st<span class="_0 blank"> </span>udy. <span class="_12 blank"> </span>A<span class="_1 blank"></span> <span class="_11 blank"> </span>study <span class="_14 blank"> </span>usi<span class="_0 blank"> </span>ng <span class="_12 blank"> </span>molec<span class="_2 blank"></span>ular<span class="_0 blank"> </span> <span class="_12 blank"> </span>do<span class="_1 blank"></span>c<span class="_0 blank"> </span>king <span class="_12 blank"> </span>was <span class="_12 blank"> </span>perfo<span class="_1 blank"></span>r<span class="_c blank"> </span>me<span class="_2 blank"></span>d<span class="_2 blank"></span> <span class="_11 blank"> </span>in </div><div class="t m0 x7 h6 y99 ff3 fs0 fc0 sc0 ls1 ws1">orde<span class="_1 blank"></span>r to <span class="_11 blank"> </span>eval<span class="_1 blank"></span>ua<span class="_0 blank"> </span>te <span class="_12 blank"> </span>t<span class="_0 blank"> </span>he <span class="_11 blank"> </span>mode <span class="_11 blank"> </span>of <span class="_12 blank"> </span>i<span class="_0 blank"> </span>nte<span class="_1 blank"></span>r<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ctio<span class="_2 blank"></span>n <span class="_11 blank"> </span>of <span class="_12 blank"> </span>96 nico<span class="_1 blank"></span>ti<span class="_0 blank"> </span>namidic<span class="_1 blank"></span> Btk<span class="_1 blank"></span> inhi<span class="_1 blank"></span>bit<span class="_0 blank"> </span>ors </div><div class="t m0 x7 h6 y9a ff3 fs0 fc0 sc0 ls1 ws1">(DELU<span class="_1 blank"></span>CC<span class="_0 blank"> </span>A <span class="_b blank"> </span>e<span class="_1 blank"></span>t <span class="_b blank"> </span>al<span class="_2 blank"></span>.,<span class="_0 blank"> </span><span class="ff6 ls6"> </span>2010). <span class="_9 blank"> </span>T<span class="_0 blank"> </span>he<span class="_1 blank"></span> <span class="_b blank"> </span>ene<span class="_1 blank"></span>rgy <span class="_9 blank"> </span>t<span class="_0 blank"> </span>erm<span class="_1 blank"></span> <span class="_b blank"> </span>values <span class="_b blank"> </span>o<span class="_1 blank"></span>f <span class="_9 blank"> </span>t<span class="_0 blank"> </span>he <span class="_9 blank"> </span>b<span class="_0 blank"> </span>e<span class="_1 blank"></span>st<span class="_0 blank"> </span> <span class="_b blank"> </span>docked </div><div class="t m0 x7 hc y9b ff3 fs0 fc0 sc0 ls1 ws1">con<span class="_1 blank"></span>f<span class="_0 blank"> </span>ormations <span class="_e blank"> </span>s<span class="_0 blank"> </span>howed<span class="_1 blank"></span> <span class="_16 blank"> </span>a<span class="_0 blank"> </span> <span class="_e blank"> </span>c<span class="_0 blank"> </span>oefficien<span class="_1 blank"></span>t<span class="_0 blank"> </span> <span class="_16 blank"> </span>of <span class="_16 blank"> </span>c<span class="_0 blank"> </span>orre<span class="_1 blank"></span>lati<span class="_0 blank"> </span>on <span class="_e blank"> </span>(R<span class="_0 blank"> </span><span class="fs4 ls4 v1">2</span>) <span class="_16 blank"> </span>equal <span class="_e blank"> </span>t<span class="_0 blank"> </span>o <span class="_e blank"> </span>0.80.<span class="_0 blank"> </span> <span class="_16 blank"> </span>We <span class="_e blank"> </span>aslo </div><div class="t m0 x7 h6 y9c ff3 fs0 fc0 sc0 ls1 ws1">used<span class="_1 blank"></span> <span class="_9 blank"> </span>the<span class="_1 blank"></span> <span class="_9 blank"> </span>rece<span class="_1 blank"></span>pt<span class="_0 blank"> </span>or<span class="_0 blank"> </span>-dependen<span class="_1 blank"></span>t <span class="_9 blank"> </span>four-dime<span class="_1 blank"></span>nsi<span class="_0 blank"> </span>onal<span class="_1 blank"></span> <span class="_9 blank"> </span>quantitative<span class="_1 blank"></span> <span class="_9 blank"> </span>structure-activi<span class="_1 blank"></span>t<span class="_0 blank"> </span>y </div><div class="t m0 x7 h6 y9d ff3 fs0 fc0 sc0 ls1 ws1">rel<span class="_1 blank"></span>a<span class="_0 blank"> </span>tionshi<span class="_1 blank"></span>p <span class="_15 blank"> </span>(RD <span class="_3 blank"> </span>4D-QSA<span class="_1 blank"></span>R) <span class="_15 blank"> </span>me<span class="_1 blank"></span>t<span class="_0 blank"> </span>hodology. <span class="_3 blank"> </span>The <span class="_3 blank"> </span>conformations <span class="_3 blank"> </span>obtained <span class="_13 blank"> </span>by </div><div class="t m0 x7 h6 y9e ff3 fs0 fc0 sc0 ls1 ws1">molec<span class="_1 blank"></span>u<span class="_0 blank"> </span>lar <span class="_12 blank"> </span>dyn<span class="_1 blank"></span>a<span class="_0 blank"> </span>mic<span class="_1 blank"></span> <span class="_12 blank"> </span>simulation <span class="_14 blank"> </span>were <span class="_14 blank"> </span>ove<span class="_1 blank"></span>r<span class="_c blank"> </span>lapped<span class="_1 blank"></span> <span class="_12 blank"> </span>in <span class="_16 blank"> </span>a<span class="_0 blank"> </span> <span class="_14 blank"> </span>virt<span class="_0 blank"> </span>ual <span class="_14 blank"> </span>three<span class="_1 blank"></span> <span class="_12 blank"> </span>dime<span class="_1 blank"></span>ns<span class="_0 blank"> </span>i<span class="_0 blank"> </span>onal </div><div class="t m0 x7 h6 y9f ff3 fs0 fc0 sc0 ls1 ws1">box <span class="_e blank"> </span>comprised <span class="_16 blank"> </span>of <span class="_e blank"> </span>2<span class="_0 blank"> </span> <span class="_16 blank"> </span>a<span class="_0 blank"> </span>nd <span class="_e blank"> </span>5<span class="_0 blank"> </span>Å <span class="_e blank"> </span>c<span class="_0 blank"> </span>ells, <span class="_e blank"> </span>a<span class="_0 blank"> </span>ccording <span class="_e blank"> </span>to <span class="_16 blank"> </span>the <span class="_16 blank"> </span>t<span class="_0 blank"> </span>hree <span class="_e blank"> </span>trial <span class="_16 blank"> </span>a<span class="_0 blank"> </span>lignm<span class="_1 blank"></span>ents.<span class="_c blank"> </span> <span class="_16 blank"> </span>T<span class="_0 blank"> </span>he </div><div class="t m0 x7 h6 ya0 ff3 fs0 fc0 sc0 ls1 ws1">mode<span class="_1 blank"></span>ls <span class="_e blank"> </span>we<span class="_1 blank"></span>r<span class="_c blank"> </span>e <span class="_f blank"> </span>generated <span class="_c blank"> </span>b<span class="_0 blank"> </span>y <span class="_c blank"> </span>a<span class="_0 blank"> </span> <span class="_f blank"> </span>com<span class="_1 blank"></span>b<span class="_0 blank"> </span>ined <span class="_f blank"> </span>gene<span class="_1 blank"></span>t<span class="_c blank"> </span>ic<span class="_1 blank"></span> <span class="_e blank"> </span>algorithm <span class="_f blank"> </span>(GA)<span class="_2 blank"></span> <span class="_f blank"> </span>a<span class="_0 blank"> </span>nd <span class="_c blank"> </span>pa<span class="_0 blank"> </span>rtial <span class="_f blank"> </span>le<span class="_1 blank"></span>a<span class="_0 blank"> </span>st </div><div class="t m0 x7 h6 ya1 ff3 fs0 fc0 sc0 ls1 ws1">square<span class="_1 blank"></span>s <span class="_14 blank"> </span>(PLS<span class="_0 blank"> </span>) <span class="_16 blank"> </span>r<span class="_0 blank"> </span>e<span class="_2 blank"></span>gression<span class="_1 blank"></span> <span class="_14 blank"> </span>t<span class="_0 blank"> </span>echniq<span class="_1 blank"></span>u<span class="_0 blank"> </span>e. <span class="_16 blank"> </span>T<span class="_0 blank"> </span>he<span class="_2 blank"></span> <span class="_16 blank"> </span>b<span class="_0 blank"> </span>est <span class="_14 blank"> </span>model <span class="_14 blank"> </span>gene<span class="_1 blank"></span>ra<span class="_0 blank"> </span>ted <span class="_e blank"> </span>a<span class="_0 blank"> </span>djusted <span class="_16 blank"> </span>cross<span class="_0 blank"> </span>-</div><div class="t m0 x7 hc ya2 ff3 fs0 fc0 sc0 ls1 ws1">valid<span class="_1 blank"></span>a<span class="_0 blank"> </span>te <span class="_c blank"> </span>value<span class="_1 blank"></span> <span class="_f blank"> </span>(q<span class="_0 blank"> </span><span class="fs4 ls4 v1">2</span><span class="fs4 ws7 v2">ad<span class="_1 blank"></span>j uste d</span></div><div class="t m0 x1c hc ya2 ff3 fs0 fc0 sc0 ls1 ws1">) <span class="_0 blank"> </span>a<span class="_0 blank"> </span>nd <span class="_0 blank"> </span> <span class="_f blank"> </span>correlation<span class="_1 blank"></span> <span class="_c blank"> </span>c<span class="_0 blank"> </span>oefficien<span class="_1 blank"></span>t<span class="_0 blank"> </span> <span class="_f blank"> </span>value<span class="_1 blank"></span> <span class="_c blank"> </span>(R<span class="_0 blank"> </span><span class="fs4 ls4 v1">2</span>) <span class="_c blank"> </span>of <span class="_c blank"> </span>0.<span class="_0 blank"> </span>67 <span class="_c blank"> </span>and<span class="_1 blank"></span> <span class="_f blank"> </span>0.74, </div><div class="t m0 x7 h6 ya3 ff3 fs0 fc0 sc0 ls1 ws1">respe<span class="_1 blank"></span>ctively. <span class="_e blank"> </span>The <span class="_f blank"> </span>RD <span class="_e blank"> </span>4D<span class="_0 blank"> </span>-QSA<span class="_1 blank"></span>R<span class="_0 blank"> </span> <span class="_e blank"> </span>analysi<span class="_1 blank"></span>s,<span class="_0 blank"> </span> <span class="_e blank"> </span>in <span class="_f blank"> </span>a<span class="_0 blank"> </span>ddition<span class="_1 blank"></span> <span class="_16 blank"> </span>to <span class="_f blank"> </span>c<span class="_0 blank"> </span>orrobo<span class="_1 blank"></span>r<span class="_0 blank"> </span>at<span class="_0 blank"> </span>ing<span class="_1 blank"></span> <span class="_16 blank"> </span>with<span class="_1 blank"></span> <span class="_e blank"> </span>t<span class="_0 blank"> </span>he </div><div class="t m0 x7 h6 ya4 ff3 fs0 fc0 sc0 ls1 ws1">docking<span class="_1 blank"></span> <span class="_f blank"> </span>r<span class="_c blank"> </span>esul<span class="_1 blank"></span>ts,<span class="_0 blank"> </span> <span class="_f blank"> </span>sugge<span class="_1 blank"></span>st<span class="_c blank"> </span>ed <span class="_c blank"> </span>a<span class="_0 blank"> </span> <span class="_16 blank"> </span>good <span class="_c blank"> </span>corr<span class="_0 blank"> </span>el<span class="_1 blank"></span>a<span class="_0 blank"> </span>tion <span class="_f blank"> </span>wi<span class="_2 blank"></span>t<span class="_0 blank"> </span>h <span class="_f blank"> </span>the <span class="_e blank"> </span>experime<span class="_1 blank"></span>nta<span class="_0 blank"> </span>l <span class="_c blank"> </span>r<span class="_c blank"> </span>esul<span class="_1 blank"></span>ts <span class="_f blank"> </span>a<span class="_0 blank"> </span>nd </div><div class="t m0 x7 h6 ya5 ff3 fs0 fc0 sc0 ls1 ws1">provided<span class="_1 blank"></span> <span class="_3 blank"> </span>m<span class="_1 blank"></span>or<span class="_0 blank"> </span>e <span class="_13 blank"> </span>detailed <span class="_13 blank"> </span>info<span class="_1 blank"></span>r<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>tion <span class="_13 blank"> </span>than <span class="_13 blank"> </span>the <span class="_13 blank"> </span>molecular <span class="_13 blank"> </span>docking<span class="_1 blank"></span>.<span class="_0 blank"> </span> <span class="_13 blank"> </span>The <span class="_3 blank"> </span>go<span class="_1 blank"></span>od </div><div class="t m0 x7 h3 ya6 ff3 fs0 fc0 sc0 ls1 ws1">poten<span class="_1 blank"></span>c<span class="_0 blank"> </span>y <span class="_0 blank"> </span>pr<span class="_c blank"> </span>e<span class="_1 blank"></span>dicted <span class="_c blank"> </span>f<span class="_0 blank"> </span>or <span class="_c blank"> </span>the<span class="_1 blank"></span> <span class="_f blank"> </span>proposed <span class="_c blank"> </span><span class="ff1 ws3">M2</span> <span class="_c blank"> </span>c<span class="_0 blank"> </span>ompo<span class="_1 blank"></span>u<span class="_0 blank"> </span>nd <span class="_c blank"> </span>indicate<span class="_1 blank"></span>s <span class="_f blank"> </span>this <span class="_0 blank"> </span>c<span class="_0 blank"> </span>om<span class="_1 blank"></span>p<span class="_0 blank"> </span>ound <span class="_0 blank"> </span>a<span class="_0 blank"> </span>s <span class="_c blank"> </span>a<span class="_0 blank"> </span> </div><div class="t m0 x7 h6 ya7 ff3 fs0 fc0 sc0 ls1 ws1">poten<span class="_1 blank"></span>tial candidate of Btk inh<span class="_1 blank"></span>ib<span class="_0 blank"> </span>itor. </div><div class="t m0 x7 h6 ya8 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 ya9 ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 yaa ff3 fs0 fc0 sc0 ls1 ws1">Keywo<span class="_1 blank"></span>r<span class="_0 blank"> </span>ds: <span class="_c blank"> </span>B-lymph<span class="ff5 ws8">RF\<span class="_1 blank"></span>W H<span class="_1 blank"></span>\ue011\ue003 \ue003 %UXWRQ¶V\ue003 7\URVLQH\ue003 .<span class="_1 blank"></span>L<span class="_0 blank"> </span>Q<span class="_2 blank"></span>DV H<span class="_1 blank"></span>\ue011\ue003 \ue003 0ROHF<span class="_1 blank"></span>X O<span class="_1 blank"></span>D U\ue003 G<span class="_1 blank"></span>RFNLQJ\ue011\ue003 \ue003 5'\ue003</span></div><div class="t m0 x7 h6 yab ff3 fs0 fc0 sc0 ls1 ws1">4D-QSA<span class="_1 blank"></span>R.<span class="_0 blank"> </span> </div><div class="t m0 x7 h9 yac ff3 fs3 fc0 sc0 ls1 ws1"> <span class="_d blank"> </span> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x8 h3 y23 ff1 fs0 fc0 sc0 ls1 ws1">LISTA DE FIGUR<span class="_1 blank"></span>A </div><div class="t m0 x19 h6 y6d ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h6 y6e ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>1 <span class="_17 blank"> </span>Fosfo<span class="_1 blank"></span>ri<span class="_0 blank"> </span>lação<span class="_1 blank"></span> <span class="_9 blank"> </span>do <span class="_18 blank"> </span>r<span class="_0 blank"> </span>esíd<span class="_1 blank"></span>u<span class="_0 blank"> </span>o <span class="_18 blank"> </span>de <span class="_18 blank"> </span>a<span class="_0 blank"> </span>minoácido<span class="_1 blank"></span> <span class="_18 blank"> </span>t<span class="_0 blank"> </span>irosin<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_18 blank"> </span>p<span class="_0 blank"> </span>or <span class="_18 blank"> </span>u<span class="_0 blank"> </span>m<span class="_1 blank"></span>a </div><div class="t m0 x1d h6 y6f ff3 fs0 fc0 sc0 ls7 ws1">en<span class="_1 blank"></span>zim<span class="_1 blank"></span>a TK <span class="_1 blank"></span>.................................................................................. <span class="_19 blank"></span>19 <span class="_1 blank"></span></div><div class="t m0 x7 h6 y70 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>2 <span class="_17 blank"> </span>Modelo<span class="_1 blank"></span> <span class="_3 blank"> </span>esquem<span class="_1 blank"></span>át<span class="_0 blank"> </span>ico <span class="_13 blank"> </span>da <span class="_3 blank"> </span>B<span class="_1 blank"></span>t<span class="_0 blank"> </span>k <span class="_3 blank"> </span>dem<span class="_1 blank"></span>onstrando <span class="_13 blank"> </span>s<span class="_0 blank"> </span>eus <span class="_13 blank"> </span>dif<span class="_0 blank"> </span>e<span class="_1 blank"></span>r<span class="_0 blank"> </span>ente<span class="_1 blank"></span>s<span class="_0 blank"> </span> </div><div class="t m0 x1d h6 y71 ff3 fs0 fc0 sc0 ls1 ws1">domínio<span class="_1 blank"></span>s: <span class="_c blank"> </span><span class="ff6">pleckstrin <span class="_0 blank"> </span>homology</span> <span class="_0 blank"> </span>(PH); <span class="_0 blank"> </span><span class="ff6">T<span class="_0 blank"> </span>ec homology<span class="_0 blank"> </span></span> <span class="_0 blank"> </span>(T<span class="_0 blank"> </span>H), <span class="_0 blank"> </span>que </div><div class="t m0 x1d h6 y72 ff3 fs0 fc0 sc0 ls1 ws1">é<span class="_1 blank"></span> <span class="_c blank"> </span>inte<span class="_2 blank"></span>rna<span class="_0 blank"> </span>me<span class="_1 blank"></span>nt<span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_c blank"> </span>dividido<span class="_1 blank"></span> <span class="_c blank"> </span>em<span class="_1 blank"></span> <span class="_0 blank"> </span><span class="ff6">Btk <span class="_0 blank"> </span>homology</span> e<span class="_1 blank"></span> <span class="_0 blank"> </span><span class="ff6">polyproline region</span> </div><div class="t m0 x1d h6 y73 ff3 fs0 fc0 sc0 ls1 ws1">(PRR); <span class="_18 blank"> </span><span class="ff6">Src <span class="_9 blank"> </span>homology</span> <span class="_18 blank"> </span>3 <span class="_9 blank"> </span>(SH3<span class="ff6">); <span class="_18 blank"> </span>Src <span class="_18 blank"> </span>homology</span> <span class="_9 blank"> </span>2 <span class="_18 blank"> </span>(SH2); </div><div class="t m0 x1d h6 y74 ff6 fs0 fc0 sc0 ls1 ws1">tyrosine kinase<span class="ff3 ls7">,<span class="_1 blank"></span> SH1<span class="_1 blank"></span> (<span class="_1 blank"></span>T<span class="_0 blank"> </span>K) <span class="_1a blank"></span>........................................................... <span class="_19 blank"></span>22<span class="_1 blank"></span> </span></div><div class="t m0 x7 h6 y75 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>3 <span class="_17 blank"> </span>Modelo<span class="_1 blank"></span> <span class="_e blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>quem<span class="_1 blank"></span>á<span class="_0 blank"> </span>t<span class="_0 blank"> </span>ico<span class="_1 blank"></span> <span class="_e blank"> </span>da <span class="_c blank"> </span>at<span class="_0 blank"> </span>iv<span class="_1 blank"></span>ação <span class="_f blank"> </span>da <span class="_0 blank"> </span>Bt<span class="_0 blank"> </span>k. <span class="_f blank"> </span>A<span class="_1 blank"></span>p<span class="_0 blank"> </span>ós <span class="_f blank"> </span>o<span class="_1 blank"></span> <span class="_f blank"> </span>ac<span class="_0 blank"> </span>oplame<span class="_1 blank"></span>nto </div><div class="t m0 x1d h6 y76 ff3 fs0 fc0 sc0 ls1 ws1">do <span class="_f blank"> </span>r<span class="_0 blank"> </span>ecepto<span class="_1 blank"></span>r<span class="_0 blank"> </span> <span class="_16 blank"> </span>de <span class="_f blank"> </span>c<span class="_0 blank"> </span>élulas <span class="_f blank"> </span>B <span class="_16 blank"> </span>(BCR) <span class="_f blank"> </span>a<span class="_0 blank"> </span> <span class="_e blank"> </span>Btk <span class="_16 blank"> </span>é <span class="_e blank"> </span>fosforil<span class="_1 blank"></span>a<span class="_c blank"> </span>da <span class="_f blank"> </span>pela <span class="_e blank"> </span>Lyn </div><div class="t m0 x1d h6 y77 ff3 fs0 fc0 sc0 ls1 ws1">ou <span class="_5 blank"> </span>Syk <span class="_4 blank"> </span>no <span class="_5 blank"> </span>r<span class="_0 blank"> </span>esíduo <span class="_5 blank"> </span>T<span class="_0 blank"> </span>yr551, <span class="_4 blank"> </span>sendo<span class="_1 blank"></span> <span class="_1b blank"> </span>en<span class="_1 blank"></span>tã<span class="_0 blank"> </span>o <span class="_5 blank"> </span>possível<span class="_1 blank"></span> <span class="_4 blank"> </span>a<span class="_c blank"> </span> </div><div class="t m0 x1d h6 y78 ff3 fs0 fc0 sc0 ls1 ws1">autofo<span class="_1 blank"></span>sf<span class="_0 blank"> </span>orilação<span class="_1 blank"></span> <span class="_3 blank"> </span>d<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_3 blank"> </span>B<span class="_1 blank"></span>t<span class="_0 blank"> </span>k <span class="_3 blank"> </span>no<span class="_1 blank"></span> <span class="_3 blank"> </span>re<span class="_1 blank"></span>s<span class="_0 blank"> </span>íduo <span class="_13 blank"> </span>Tyr223. <span class="_3 blank"> </span>A<span class="_1 blank"></span>ssim, <span class="_3 blank"> </span>a <span class="_1c blank"> </span>Btk<span class="_1 blank"></span> </div><div class="t m0 x1d h6 y79 ff3 fs0 fc0 sc0 ls1 ws9">torn<span class="_1 blank"></span>a -<span class="ff5 wsa">V<span class="_0 blank"> </span>H\ue003<span class="_10 blank"> </span>D W LYD\ue003<span class="_8 blank"> </span>H\ue003<span class="_10 blank"> </span>I RVIRULOD\ue003<span class="_7 blank"> </span>D\ue003<span class="_8 blank"> </span>IR<span class="_1 blank"></span>VI<span class="_0 blank"> </span>ROLSDVH\ue003<span class="_10 blank"> </span>& \u0216\ue003<span class="_8 blank"> </span>OHYDQGR<span class="_1 blank"></span>\ue003<span class="_5 blank"> </span><span class="ff3 ws1">à </span></span></div><div class="t m0 x1d h6 y33 ff3 fs0 fc0 sc0 ls7 ws1">m<span class="_1 blank"></span>obili<span class="_1 blank"></span>zaç<span class="_1 blank"></span>ão<span class="_2 blank"></span> de<span class="_1 blank"></span> c<span class="_1 blank"></span>á<span class="_0 blank"> </span>lcio <span class="_1a blank"></span>.................................................................. <span class="_19 blank"></span>23<span class="_1 blank"></span> </div><div class="t m0 x7 h6 y34 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>4 <span class="_17 blank"> </span>Mudan<span class="_1 blank"></span>ça <span class="_e blank"> </span>c<span class="_0 blank"> </span>onform<span class="_2 blank"></span>acional <span class="_f blank"> </span>s<span class="_0 blank"> </span>of<span class="_1 blank"></span>r<span class="_0 blank"> </span>ida <span class="_e blank"> </span>p<span class="_0 blank"> </span>e<span class="_1 blank"></span>la <span class="_e blank"> </span>Bt<span class="_0 blank"> </span>k<span class="_2 blank"></span> <span class="_e blank"> </span>ao <span class="_e blank"> </span>interagi<span class="_2 blank"></span>r <span class="_e blank"> </span>com <span class="_e blank"> </span>o </div><div class="t m0 x1d h6 y35 ff3 fs0 fc0 sc0 ls1 ws1">ini<span class="_1 blank"></span>b<span class="_0 blank"> </span>idor <span class="_c blank"> </span>CGI746 <span class="_c blank"> </span>(am<span class="_1 blank"></span>ar<span class="_0 blank"> </span>elo<span class="_2 blank"></span>) <span class="_0 blank"> </span>r<span class="_0 blank"> </span>esultando <span class="_c blank"> </span>no <span class="_0 blank"> </span>seque<span class="_2 blank"></span>stro <span class="_f blank"> </span>do <span class="_0 blank"> </span>resíd<span class="_1 blank"></span>u<span class="_0 blank"> </span>o </div><div class="t m0 x1d h6 y36 ff3 fs0 fc0 sc0 ls1 ws1">Tyr551. <span class="_3 blank"> </span>Em<span class="_1 blank"></span> <span class="_15 blank"> </span>ve<span class="_1 blank"></span>r<span class="_c blank"> </span>de <span class="_3 blank"> </span>está <span class="_15 blank"> </span>a <span class="_3 blank"> </span>Btk <span class="_3 blank"> </span>na <span class="_3 blank"> </span>confo<span class="_1 blank"></span>r<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>ção <span class="_3 blank"> </span>liga<span class="_0 blank"> </span>da <span class="_3 blank"> </span>a<span class="_0 blank"> </span>o<span class="_1 blank"></span> </div><div class="t m0 x1d h6 y37 ff3 fs0 fc0 sc0 ls1 ws1">ini<span class="_1 blank"></span>b<span class="_0 blank"> </span>idor, <span class="_c blank"> </span>e <span class="_c blank"> </span>em<span class="_1 blank"></span> <span class="_f blank"> </span>cinza,<span class="_0 blank"> </span> <span class="_c blank"> </span>em<span class="_1 blank"></span> <span class="_c blank"> </span>sua<span class="_0 blank"> </span> <span class="_c blank"> </span>form<span class="_2 blank"></span>a <span class="_c blank"> </span>a<span class="_0 blank"> </span>po. <span class="_c blank"> </span>O <span class="_c blank"> </span>resíd<span class="_1 blank"></span>u<span class="_0 blank"> </span>o <span class="_0 blank"> </span>T<span class="_0 blank"> </span>yr551 <span class="_c blank"> </span>em </div><div class="t m0 x1d h6 y38 ff3 fs0 fc0 sc0 ls1 ws1">am<span class="_1 blank"></span>ba<span class="_0 blank"> </span>s <span class="_c blank"> </span>a<span class="_0 blank"> </span>s <span class="_0 blank"> </span>confo<span class="_1 blank"></span>r<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>çõe<span class="_1 blank"></span>s <span class="_f blank"> </span>é <span class="_c blank"> </span>mo<span class="_1 blank"></span>st<span class="_0 blank"> </span>ra<span class="_0 blank"> </span>do <span class="_0 blank"> </span>como <span class="_c blank"> </span>esfe<span class="_1 blank"></span>r<span class="_0 blank"> </span>as.<span class="_0 blank"> </span> <span class="_c blank"> </span>Os <span class="_0 blank"> </span>resíduos </div><div class="t m0 x1d h6 y39 ff3 fs0 fc0 sc0 ls1 ws1">de<span class="_1 blank"></span> <span class="_1d blank"> </span>a<span class="_0 blank"> </span>mino<span class="_1 blank"></span>á<span class="_0 blank"> </span>cidos <span class="_1d blank"> </span>q<span class="_1 blank"></span>u<span class="_0 blank"> </span>e <span class="_1e blank"> </span>constituem <span class="_1e blank"> </span>o <span class="_1e blank"> </span>bolsão <span class="_1e blank"> </span>H3<span class="_0 blank"> </span> <span class="_1e blank"> </span>estão </div><div class="t m0 x1d h6 y3a ff3 fs0 fc0 sc0 ls7 ws1">de<span class="_1 blank"></span>mo<span class="_2 blank"></span>nst<span class="_1 blank"></span>r<span class="_0 blank"> </span>ad<span class="_1 blank"></span>os<span class="_1 blank"></span> <span class="_0 blank"> </span>à d<span class="_1 blank"></span>ire<span class="_1 blank"></span>ita.<span class="_1 blank"></span> <span class="_1a blank"></span>................................................................ <span class="_19 blank"></span>2<span class="_1 blank"></span>6 </div><div class="t m0 x7 h6 y3b ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>5 <span class="_17 blank"> </span>Estrutura <span class="_e blank"> </span>terci<span class="_1 blank"></span>á<span class="_0 blank"> </span>ria <span class="_16 blank"> </span>da <span class="_e blank"> </span>Btk <span class="_16 blank"> </span>obtid<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_e blank"> </span>do <span class="_16 blank"> </span>PDB <span class="_e blank"> </span>(código<span class="_1 blank"></span> <span class="_16 blank"> </span>3O<span class="_0 blank"> </span>CS<span class="_0 blank"> </span>). <span class="_e blank"> </span>As </div><div class="t m0 x1d h6 y3c ff5 fs0 fc0 sc0 ls1 ws2">\u012e<span class="ff3 ws1">-héli<span class="_1 blank"></span>c<span class="_0 blank"> </span>es estão re<span class="_1 blank"></span>pr<span class="_c blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entadas em<span class="_1 blank"></span> <span class="_13 blank"> </span>ve<span class="_1 blank"></span>r<span class="_0 blank"> </span>melho<span class="_1 blank"></span>,<span class="_0 blank"> </span> as folh<span class="_1 blank"></span>a<span class="_c blank"> </span>s<span class="_0 blank"> </span>-<span class="ff5 wsb">\u0215\ue003 HP<span class="_1 blank"></span>\ue003</span></span></div><div class="t m0 x1d h6 y3d ff3 fs0 fc0 sc0 ls7 ws1">azu<span class="_1 blank"></span>l e<span class="_1 blank"></span> o<span class="_1 blank"></span> síti<span class="_1 blank"></span>o ati<span class="_1 blank"></span>vo<span class="_1 blank"></span> <span class="_0 blank"> </span>em<span class="_1 blank"></span> ve<span class="_1 blank"></span>rde ........................................................ <span class="_1f blank"></span>41 <span class="_1 blank"></span></div><div class="t m0 x7 h6 y3e ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>6 <span class="_17 blank"> </span>Cavid<span class="_1 blank"></span>a<span class="_0 blank"> </span>de d<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_0 blank"> </span>enzim<span class="_1 blank"></span>a <span class="_0 blank"> </span>BTK il<span class="_2 blank"></span>ustra<span class="_0 blank"> </span>da<span class="_2 blank"></span> em<span class="_1 blank"></span> <span class="_0 blank"> </span>verde<span class="_0 blank"> </span> <span class="_19 blank"></span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span> <span class="_19 blank"></span>51 </div><div class="t m0 x7 h6 yad ff3 fs0 fc1 sc0 ls1 ws1"> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x7 h6 y90 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>7 <span class="_17 blank"> </span>Estrutura do lig<span class="_1 blank"></span>a<span class="_0 blank"> </span>nte 4-t<span class="_0 blank"> </span>e<span class="_1 blank"></span>r<span class="_0 blank"> </span>c-butil-N-[2-me<span class="_1 blank"></span>t<span class="_0 blank"> </span>il-3-(4-metil<span class="_1 blank"></span>-6-{[4-</div><div class="t m0 x1d h6 y6d ff3 fs0 fc0 sc0 ls1 ws1">(mo<span class="_1 blank"></span>r<span class="_0 blank"> </span>folin-4-ilcarbonil<span class="_1 blank"></span>)f<span class="_0 blank"> </span>enil]<span class="_1 blank"></span> <span class="_c blank"> </span>a<span class="_0 blank"> </span>mino} -5-<span class="_0 blank"> </span>oxi-4,5-dih<span class="_1 blank"></span>idr<span class="_0 blank"> </span>opirazin<span class="_1 blank"></span>-</div><div class="t m0 x1d h6 y6e ff3 fs0 fc0 sc0 ls1 ws1">2-il)<span class="_1 blank"></span>f<span class="_0 blank"> </span>enil]benzamid<span class="_1 blank"></span>a <span class="_10 blank"> </span>(CGI<span class="_2 blank"></span>1746) <span class="_a blank"> </span>que <span class="_a blank"> </span>f<span class="_0 blank"> </span>oi<span class="_1 blank"></span> <span class="_10 blank"> </span>obtido<span class="_1 blank"></span> <span class="_10 blank"> </span>do <span class="_a blank"> </span>PDB </div><div class="t m0 x1d h6 y6f ff3 fs0 fc0 sc0 ls7 ws1">(có<span class="_1 blank"></span>dig<span class="_1 blank"></span>o 3<span class="_1 blank"></span>OCS) <span class="_20 blank"></span>............................................................................ <span class="_1f blank"></span>52 </div><div class="t m0 x7 h6 y70 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>8 <span class="_17 blank"> </span>A<span class="_1 blank"></span> <span class="_c blank"> </span>figura ilustr<span class="_0 blank"> </span>a a superfície<span class="_1 blank"></span> <span class="_c blank"> </span>eletrostática da Btk e <span class="_0 blank"> </span>os <span class="_0 blank"> </span>inibid<span class="_2 blank"></span>o<span class="_2 blank"></span>r<span class="_0 blank"> </span>es </div><div class="t m0 x1d h3 y71 ff1 fs0 fc0 sc0 ls1 ws3">14<span class="ff3 ws1"> <span class="_9 blank"> </span>(em<span class="_1 blank"></span> <span class="_b blank"> </span>ve<span class="_2 blank"></span>r<span class="_0 blank"> </span>de)<span class="_1 blank"></span> <span class="_b blank"> </span>e <span class="_9 blank"> </span><span class="ff1 ws3">59</span> <span class="_b blank"> </span>(em<span class="_1 blank"></span> <span class="_b blank"> </span>am<span class="_1 blank"></span>a<span class="_0 blank"> </span>r<span class="_0 blank"> </span>elo<span class="_1 blank"></span>), <span class="_b blank"> </span>n<span class="_2 blank"></span>a <span class="_b blank"> </span>con<span class="_1 blank"></span>for<span class="_0 blank"> </span>m<span class="_1 blank"></span>a<span class="_c blank"> </span>ção <span class="_9 blank"> </span>de </span></div><div class="t m0 x1d h6 y72 ff3 fs0 fc0 sc0 ls7 ws1">an<span class="_1 blank"></span>coram<span class="_1 blank"></span>en<span class="_1 blank"></span>to <span class="_19 blank"></span>................................................................................ <span class="_1f blank"></span>55 </div><div class="t m0 x7 h3 y73 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>9 <span class="_17 blank"> </span>A<span class="_1 blank"></span> <span class="_c blank"> </span>fi<span class="_0 blank"> </span>gura <span class="_0 blank"> </span>ilustra <span class="_0 blank"> </span>o <span class="_0 blank"> </span>bol<span class="_1 blank"></span>sã<span class="_0 blank"> </span>o <span class="_0 blank"> </span>H3 <span class="_0 blank"> </span>na <span class="_0 blank"> </span>Btk <span class="_c blank"> </span>e<span class="_1 blank"></span> <span class="_f blank"> </span>o<span class="_2 blank"></span>s <span class="_0 blank"> </span>inibidores: <span class="_0 blank"> </span>A) <span class="_f blank"> </span><span class="ff1 ws3">14</span> <span class="_0 blank"> </span>(em </div><div class="t m0 x1d h3 y74 ff3 fs0 fc0 sc0 ls1 ws1">ve<span class="_1 blank"></span>r<span class="_0 blank"> </span>de) <span class="_15 blank"> </span>e <span class="_3 blank"> </span><span class="ff1">65 <span class="_15 blank"> </span></span>(em <span class="_3 blank"> </span>a<span class="_0 blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>relo); <span class="_3 blank"> </span>B) <span class="_3 blank"> </span><span class="ff1">14 <span class="_15 blank"> </span></span>(em <span class="_15 blank"> </span>ve<span class="_1 blank"></span>r<span class="_0 blank"> </span>de) <span class="_15 blank"> </span>e <span class="_15 blank"> </span><span class="ff1">75 <span class="_3 blank"> </span></span>(em </div><div class="t m0 x1d h3 y75 ff3 fs0 fc0 sc0 ls1 ws1">am<span class="_1 blank"></span>a<span class="_0 blank"> </span>relo); <span class="_f blank"> </span>C) <span class="_16 blank"> </span><span class="ff1 ws3">14</span> <span class="_e blank"> </span>(em<span class="_1 blank"></span> <span class="_e blank"> </span>verde) <span class="_e blank"> </span>e<span class="_1 blank"></span> <span class="_16 blank"> </span><span class="ff1">59 <span class="_e blank"> </span></span>(em <span class="_f blank"> </span>a<span class="_c blank"> </span>m<span class="_1 blank"></span>a<span class="_0 blank"> </span>relo), <span class="_f blank"> </span>a<span class="_0 blank"> </span>nc<span class="_1 blank"></span>or<span class="_0 blank"> </span>ado<span class="_1 blank"></span>s <span class="_16 blank"> </span>no </div><div class="t m0 x1d h6 y76 ff3 fs0 fc0 sc0 ls7 ws1">sí<span class="_1 blank"></span>tio<span class="_1 blank"></span> ati<span class="_1 blank"></span>vo <span class="_2 blank"></span>d<span class="_1 blank"></span>a <span class="_0 blank"> </span>e<span class="_1 blank"></span>nzim<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_19 blank"></span>.................................................................... <span class="_1f blank"></span>56 </div><div class="t m0 x7 h3 y77 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>10 <span class="_6 blank"> </span>Il<span class="_1 blank"></span>ustr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção <span class="_0 blank"> </span>da <span class="_c blank"> </span>con<span class="_1 blank"></span>f<span class="_0 blank"> </span>or<span class="_0 blank"> </span>m<span class="_1 blank"></span>açã<span class="_0 blank"> </span>o <span class="_c blank"> </span>de<span class="_1 blank"></span> <span class="_f blank"> </span>anc<span class="_0 blank"> </span>oramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_c blank"> </span>da <span class="_f blank"> </span>m<span class="_1 blank"></span>olécula <span class="_e blank"> </span><span class="ff1 ws3">59.</span> <span class="_0 blank"> </span>O </div><div class="t m0 x1d h6 y78 ff3 fs0 fc0 sc0 ls1 ws1">átomo<span class="_2 blank"></span> <span class="_9 blank"> </span>de<span class="_1 blank"></span> <span class="_9 blank"> </span>flúor <span class="_9 blank"> </span>no<span class="_1 blank"></span> <span class="_18 blank"> </span>a<span class="_0 blank"> </span>nel <span class="_9 blank"> </span>de<span class="_1 blank"></span> <span class="_9 blank"> </span>nicotina<span class="_0 blank"> </span>m<span class="_1 blank"></span>ida <span class="_9 blank"> </span>e <span class="_18 blank"> </span>o <span class="_15 blank"> </span>á<span class="_0 blank"> </span>tomo <span class="_18 blank"> </span>de </div><div class="t m0 x1d h6 y79 ff3 fs0 fc0 sc0 ls1 ws1">nitrogê<span class="_1 blank"></span>nio <span class="_0 blank"> </span>da pipe<span class="_1 blank"></span>ri<span class="_0 blank"> </span>dina e<span class="_1 blank"></span>st<span class="_0 blank"> </span>ão <span class="_0 blank"> </span>m<span class="_1 blank"></span>ar<span class="_0 blank"> </span>cado<span class="_1 blank"></span>s<span class="_0 blank"> </span> <span class="_0 blank"> </span>em<span class="_1 blank"></span> <span class="_c blank"> </span>ve<span class="_1 blank"></span>r<span class="_0 blank"> </span>de<span class="_0 blank"> </span> <span class="_1 blank"></span>.<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span> <span class="_19 blank"></span>57 </div><div class="t m0 x7 h6 y33 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>11 <span class="_6 blank"> </span>Im<span class="_1 blank"></span>a<span class="_0 blank"> </span>gem<span class="_2 blank"></span> <span class="_16 blank"> </span>i<span class="_0 blank"> </span>lustrativ<span class="_1 blank"></span>a <span class="_16 blank"> </span>do <span class="_e blank"> </span>c<span class="_0 blank"> </span>orte <span class="_e blank"> </span>r<span class="_0 blank"> </span>e<span class="_1 blank"></span>a<span class="_0 blank"> </span>lizado <span class="_e blank"> </span>na <span class="_14 blank"> </span>en<span class="_1 blank"></span>z<span class="_0 blank"> </span>im<span class="_1 blank"></span>a<span class="_0 blank"> </span> <span class="_16 blank"> </span>Btk <span class="_16 blank"> </span>(código </div><div class="t m0 x1d h6 y34 ff3 fs0 fc0 sc0 ls1 ws1">3OCS) <span class="_16 blank"> </span>a<span class="_0 blank"> </span>o <span class="_16 blank"> </span>redor <span class="_14 blank"> </span>do<span class="_1 blank"></span> <span class="_12 blank"> </span>lig<span class="_1 blank"></span>a<span class="_c blank"> </span>nte<span class="_1 blank"></span> <span class="_14 blank"> </span>CGI1746, <span class="_14 blank"> </span>a <span class="_14 blank"> </span>fim <span class="_14 blank"> </span>de<span class="_1 blank"></span> <span class="_12 blank"> </span>s<span class="_0 blank"> </span>elecionar<span class="_0 blank"> </span> <span class="_16 blank"> </span>os </div><div class="t m0 x1d h6 y35 ff3 fs0 fc0 sc0 ls1 ws1">resíd<span class="_1 blank"></span>u<span class="_0 blank"> </span>os <span class="_11 blank"> </span>de <span class="_12 blank"> </span>a<span class="_0 blank"> </span>minoácido<span class="_1 blank"></span>s <span class="_11 blank"> </span>a<span class="_0 blank"> </span> <span class="_11 blank"> </span>s<span class="_0 blank"> </span>erem<span class="_1 blank"></span> <span class="_11 blank"> </span>ut<span class="_0 blank"> </span>ilizados <span class="_12 blank"> </span>na m<span class="_1 blank"></span>et<span class="_0 blank"> </span>odologi<span class="_1 blank"></span>a<span class="_0 blank"> </span> </div><div class="t m0 x1d h6 y36 ff3 fs0 fc0 sc0 ls7 ws1">QSA<span class="_1 blank"></span>R-<span class="_1 blank"></span>4D D<span class="_2 blank"></span>R p<span class="_1 blank"></span>ara<span class="_1 blank"></span> os<span class="_1 blank"></span> 96 co<span class="_1 blank"></span>m<span class="_1 blank"></span>pos<span class="_2 blank"></span>to<span class="_1 blank"></span>s<span class="_0 blank"> </span> <span class="_20 blank"></span>........................................... <span class="_19 blank"></span>59<span class="_1 blank"></span> </div><div class="t m0 x7 h6 y37 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>12 <span class="_6 blank"> </span>Modelo<span class="_1 blank"></span> <span class="_14 blank"> </span>de<span class="_1 blank"></span> <span class="_14 blank"> </span>QS<span class="_0 blank"> </span>AR-4D <span class="_16 blank"> </span>DR <span class="_14 blank"> </span>repre<span class="_1 blank"></span>s<span class="_0 blank"> </span>entativo<span class="_1 blank"></span> <span class="_12 blank"> </span>do<span class="_2 blank"></span> <span class="_16 blank"> </span>a<span class="_0 blank"> </span>linh<span class="_1 blank"></span>a<span class="_c blank"> </span>mento <span class="_14 blank"> </span><span class="ff6 ws3">1a</span>, </div><div class="t m0 x1d h3 y38 ff3 fs0 fc0 sc0 ls1 ws1">mo<span class="_1 blank"></span>str<span class="_0 blank"> </span>ando<span class="_1 blank"></span> <span class="_c blank"> </span>o com<span class="_1 blank"></span>p<span class="_0 blank"> </span>osto<span class="_1 blank"></span> <span class="_0 blank"> </span><span class="ff1 wsc">59 </span><span class="ls7"> <span class="_21 blank"></span>............................................................ <span class="_1f blank"></span>69 </span></div><div class="t m0 x7 h3 y39 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>13 <span class="_6 blank"> </span>Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_16 blank"> </span>da <span class="_16 blank"> </span>molé<span class="_1 blank"></span>cu<span class="_0 blank"> </span>la <span class="_16 blank"> </span><span class="ff1 ws3">14</span> <span class="_16 blank"> </span>e <span class="_16 blank"> </span>do <span class="_e blank"> </span>GCOD-1 <span class="_e blank"> </span>(<span class="_0 blank"> </span>esfera <span class="_16 blank"> </span>bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) </div><div class="t m0 x1d h6 y3a ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o<span class="ff6"> 1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>70 <span class="_1 blank"></span></span></div><div class="t m0 x7 h3 y3b ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>14 <span class="_6 blank"> </span>A<span class="_1 blank"></span>) <span class="_15 blank"> </span>Repr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_3 blank"> </span>da <span class="_15 blank"> </span>mo<span class="_2 blank"></span>lécula <span class="_15 blank"> </span><span class="ff1 ws3">53</span> <span class="_3 blank"> </span>e <span class="_15 blank"> </span>do<span class="_1 blank"></span> <span class="_15 blank"> </span>GCOD-2 <span class="_15 blank"> </span>(esfe<span class="_1 blank"></span>r<span class="_0 blank"> </span>a </div><div class="t m0 x1d h6 y3c ff3 fs0 fc0 sc0 ls1 ws1">bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) <span class="_1b blank"> </span>obtido <span class="_1b blank"> </span>do <span class="_1e blank"> </span>Modelo<span class="_1 blank"></span>1<span class="_0 blank"> </span> <span class="_1e blank"> </span>do <span class="_1b blank"> </span>a<span class="_0 blank"> </span>linh<span class="_1 blank"></span>a<span class="_0 blank"> </span>men<span class="_1 blank"></span>t<span class="_0 blank"> </span>o<span class="_0 blank"> </span><span class="ff6"> <span class="_1e blank"> </span>1a; <span class="_1e blank"> </span></span>B<span class="_1 blank"></span>)<span class="_0 blank"> </span> </div><div class="t m0 x1d h3 y3d ff3 fs0 fc0 sc0 ls1 ws1">Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>esen<span class="_1 blank"></span>t<span class="_0 blank"> </span>ação <span class="_16 blank"> </span>da <span class="_16 blank"> </span>molé<span class="_2 blank"></span>cula <span class="_16 blank"> </span><span class="ff1">59 <span class="_16 blank"> </span></span>e <span class="_16 blank"> </span>do <span class="_e blank"> </span>GCOD-3 <span class="_e blank"> </span>(<span class="_0 blank"> </span>esfera <span class="_16 blank"> </span>br<span class="_0 blank"> </span>anca)<span class="_1 blank"></span> </div><div class="t m0 x1d h6 y3e ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o<span class="ff6"> 1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>73 <span class="_1 blank"></span></span></div><div class="t m0 x7 h6 yad ff3 fs0 fc1 sc0 ls1 ws1"> </div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><div class="c x1 y1 w2 h2"><div class="t m0 x7 h3 y90 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>15 <span class="_6 blank"> </span>A<span class="_1 blank"></span>) <span class="_15 blank"> </span>Repr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_3 blank"> </span>da <span class="_15 blank"> </span>mo<span class="_2 blank"></span>lécula <span class="_15 blank"> </span><span class="ff1 ws3">53</span> <span class="_3 blank"> </span>e <span class="_15 blank"> </span>do<span class="_1 blank"></span> <span class="_15 blank"> </span>GCOD-4 <span class="_15 blank"> </span>(esfe<span class="_1 blank"></span>r<span class="_0 blank"> </span>a </div><div class="t m0 x1d h6 y6d ff3 fs0 fc0 sc0 ls1 ws1">bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) <span class="_8 blank"> </span>obtido<span class="_1 blank"></span> <span class="_5 blank"> </span>do<span class="_1 blank"></span> <span class="_8 blank"> </span>M<span class="_0 blank"> </span>odelo<span class="_1 blank"></span>1<span class="_0 blank"> </span> <span class="_8 blank"> </span>do <span class="_8 blank"> </span>a<span class="_0 blank"> </span>linh<span class="_1 blank"></span>a<span class="_c blank"> </span>men<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_8 blank"> </span><span class="ff6 wsc">1a </span> <span class="_8 blank"> </span>; <span class="_8 blank"> </span>B) </div><div class="t m0 x1d h3 y6e ff3 fs0 fc0 sc0 ls1 ws1">Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>esen<span class="_1 blank"></span>t<span class="_0 blank"> </span>ação <span class="_11 blank"> </span>da m<span class="_1 blank"></span>oléc<span class="_1 blank"></span>u<span class="_0 blank"> </span>la <span class="ff1 ws3">49</span> <span class="_12 blank"> </span>e <span class="_12 blank"> </span>do <span class="_11 blank"> </span>GCOD-5 <span class="_12 blank"> </span>(<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>f<span class="_0 blank"> </span>era <span class="_11 blank"> </span>pre<span class="_1 blank"></span>ta<span class="_0 blank"> </span>) </div><div class="t m0 x1d h6 y6f ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="ff6 ws3">1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>75 <span class="_1 blank"></span></span></div><div class="t m0 x7 h3 y70 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>16 <span class="_6 blank"> </span>Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_16 blank"> </span>da <span class="_16 blank"> </span>molé<span class="_1 blank"></span>cu<span class="_0 blank"> </span>la <span class="_16 blank"> </span><span class="ff1 ws3">59</span> <span class="_16 blank"> </span>e <span class="_16 blank"> </span>do <span class="_e blank"> </span>GCOD-6 <span class="_e blank"> </span>(<span class="_0 blank"> </span>esfera <span class="_16 blank"> </span>bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) </div><div class="t m0 x1d h6 y71 ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="ff6 ws3">1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>77 <span class="_1 blank"></span></span></div><div class="t m0 x7 h3 y72 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>17 <span class="_6 blank"> </span>A<span class="_1 blank"></span>) <span class="_15 blank"> </span>Repr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_3 blank"> </span>da <span class="_15 blank"> </span>mo<span class="_2 blank"></span>lécula <span class="_15 blank"> </span><span class="ff1 ws3">55</span> <span class="_3 blank"> </span>e <span class="_15 blank"> </span>do<span class="_1 blank"></span> <span class="_15 blank"> </span>GCOD-7 <span class="_15 blank"> </span>(esfe<span class="_1 blank"></span>r<span class="_0 blank"> </span>a </div><div class="t m0 x1d h6 y73 ff3 fs0 fc0 sc0 ls1 ws1">bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) <span class="_1e blank"> </span>o<span class="_1 blank"></span>bt<span class="_0 blank"> </span>ido<span class="_1 blank"></span> <span class="_1d blank"> </span>do<span class="_1 blank"></span> <span class="_1e blank"> </span>M<span class="_0 blank"> </span>odelo1 <span class="_1e blank"> </span>do <span class="_1b blank"> </span>a<span class="_0 blank"> </span>linh<span class="_1 blank"></span>a<span class="_c blank"> </span>men<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_1d blank"> </span><span class="ff6 ws3">1a</span>. <span class="_1e blank"> </span>B) </div><div class="t m0 x1d h3 y74 ff3 fs0 fc0 sc0 ls1 ws1">Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>esen<span class="_1 blank"></span>t<span class="_0 blank"> </span>ação <span class="_11 blank"> </span>da m<span class="_1 blank"></span>oléc<span class="_1 blank"></span>u<span class="_0 blank"> </span>la <span class="ff1 ws3">61</span> <span class="_12 blank"> </span>e <span class="_12 blank"> </span>do <span class="_11 blank"> </span>GCOD-8 <span class="_12 blank"> </span>(<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>f<span class="_0 blank"> </span>era <span class="_11 blank"> </span>pre<span class="_1 blank"></span>ta<span class="_0 blank"> </span>) </div><div class="t m0 x1d h6 y75 ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="ff6 ws3">1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>79 <span class="_1 blank"></span></span></div><div class="t m0 x7 h3 y76 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>18 <span class="_6 blank"> </span>Re<span class="_1 blank"></span>pr<span class="_0 blank"> </span>e<span class="_1 blank"></span>s<span class="_0 blank"> </span>entação <span class="_16 blank"> </span>da <span class="_16 blank"> </span>molé<span class="_1 blank"></span>cu<span class="_0 blank"> </span>la <span class="_16 blank"> </span><span class="ff1 ws3">55</span> <span class="_16 blank"> </span>e <span class="_16 blank"> </span>do <span class="_e blank"> </span>GCOD-9 <span class="_e blank"> </span>(<span class="_0 blank"> </span>esfera <span class="_16 blank"> </span>bra<span class="_0 blank"> </span>nc<span class="_1 blank"></span>a<span class="_0 blank"> </span>) </div><div class="t m0 x1d h6 y77 ff3 fs0 fc0 sc0 ls1 ws1">obtido<span class="_1 blank"></span> do M<span class="_0 blank"> </span>ode<span class="_2 blank"></span>lo1 do alinhamen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="ff6 ws3">1a</span><span class="ls7"> <span class="_21 blank"></span>......................................... <span class="_1f blank"></span>80 <span class="_1 blank"></span></span></div><div class="t m0 x7 h3 y78 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>19 <span class="_6 blank"> </span>Il<span class="_1 blank"></span>ustr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção <span class="_1e blank"> </span>da <span class="_1e blank"> </span>mo<span class="_1 blank"></span>lécu<span class="_0 blank"> </span>la <span class="_1d blank"> </span><span class="ff1 ws3">59</span> <span class="_1e blank"> </span>em<span class="_1 blank"></span> <span class="_1d blank"> </span>sua <span class="_1d blank"> </span>co<span class="_1 blank"></span>nformação <span class="_1e blank"> </span>de </div><div class="t m0 x1d h6 y79 ff3 fs0 fc0 sc0 ls1 ws1">ancoramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o. <span class="_0 blank"> </span>As <span class="_c blank"> </span>ligações <span class="_0 blank"> </span>de <span class="_c blank"> </span>hidrogênio <span class="_0 blank"> </span>sã<span class="_0 blank"> </span>o <span class="_0 blank"> </span>demonstradas <span class="_c blank"> </span>em </div><div class="t m0 x1d h6 y33 ff3 fs0 fc0 sc0 ls1 ws1">azul e a distância do átomo de flúor (<span class="_0 blank"> </span>em<span class="_1 blank"></span> <span class="_0 blank"> </span>ci<span class="_0 blank"> </span>nz<span class="_1 blank"></span>a<span class="_0 blank"> </span>) <span class="_0 blank"> </span>e<span class="_1 blank"></span> <span class="_c blank"> </span>do r<span class="_0 blank"> </span>e<span class="_1 blank"></span>sí<span class="_0 blank"> </span>duo<span class="_1 blank"></span> <span class="_0 blank"> </span>d<span class="_0 blank"> </span>e </div><div class="t m0 x1d h6 y34 ff3 fs0 fc0 sc0 ls7 ws1">Ly<span class="_1 blank"></span>s43<span class="_1 blank"></span>0 é<span class="_1 blank"></span> <span class="_0 blank"> </span>de<span class="_2 blank"></span>m<span class="_1 blank"></span>on<span class="_1 blank"></span>strad<span class="_2 blank"></span>a em<span class="_20 blank"></span> <span class="_0 blank"> </span>ve<span class="_1 blank"></span>rde <span class="_19 blank"></span>.................................................. <span class="_19 blank"></span>83 <span class="_1 blank"></span></div><div class="t m0 x7 h3 y35 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>20 <span class="_6 blank"> </span>Il<span class="_1 blank"></span>ustr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção <span class="_1e blank"> </span>da <span class="_1e blank"> </span>mo<span class="_1 blank"></span>lécu<span class="_0 blank"> </span>la <span class="_1d blank"> </span><span class="ff1 ws3">59</span> <span class="_1e blank"> </span>em<span class="_1 blank"></span> <span class="_1d blank"> </span>sua <span class="_1d blank"> </span>co<span class="_1 blank"></span>nformação <span class="_1e blank"> </span>de </div><div class="t m0 x1d h6 y36 ff3 fs0 fc0 sc0 ls1 ws1">ancoramen<span class="_1 blank"></span>t<span class="_0 blank"> </span>o <span class="_e blank"> </span>e<span class="_1 blank"></span> <span class="_16 blank"> </span>das <span class="_e blank"> </span>r<span class="_0 blank"> </span>e<span class="_1 blank"></span>pr<span class="_0 blank"> </span>esen<span class="_1 blank"></span>ta<span class="_0 blank"> </span>çõe<span class="_1 blank"></span>s <span class="_16 blank"> </span>dos <span class="_f blank"> </span>potenciais <span class="_e blank"> </span>ele<span class="_1 blank"></span>tr<span class="_c blank"> </span>ostático </div><div class="t m0 x1d h6 y37 ff3 fs0 fc0 sc0 ls1 ws1">posi<span class="_1 blank"></span>t<span class="_0 blank"> </span>ivo <span class="_14 blank"> </span>(em <span class="_14 blank"> </span>azul) <span class="_14 blank"> </span>e <span class="_12 blank"> </span>neg<span class="_1 blank"></span>a<span class="_0 blank"> </span>tivo <span class="_14 blank"> </span>(em <span class="_12 blank"> </span>ve<span class="_1 blank"></span>r<span class="_c blank"> </span>melho<span class="_1 blank"></span>). <span class="_12 blank"> </span>Os <span class="_14 blank"> </span>átomos <span class="_14 blank"> </span>de </div><div class="t m0 x1d h6 y38 ff3 fs0 fc0 sc0 ls1 ws1">fl<span class="_1 blank"></span>ú<span class="_0 blank"> </span>or (cinza) estão i<span class="_1 blank"></span>ndica<span class="_0 blank"> </span>dos em<span class="_1 blank"></span> <span class="_0 blank"> </span>ve<span class="_1 blank"></span>r<span class="_c blank"> </span>de <span class="_1a blank"></span>.<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>...<span class="_0 blank"> </span>.<span class="_0 blank"> </span>...<span class="_0 blank"> </span>..<span class="_0 blank"> </span>..<span class="_0 blank"> </span>. <span class="_19 blank"></span>84 </div><div class="t m0 x7 h3 y39 ff3 fs0 fc0 sc0 ls1 ws1">Fig<span class="_1 blank"></span>ur<span class="_0 blank"> </span>a <span class="_0 blank"> </span>21 <span class="_6 blank"> </span>Il<span class="_1 blank"></span>ustr<span class="_0 blank"> </span>a<span class="_0 blank"> </span>ção d<span class="_1 blank"></span>a<span class="_0 blank"> </span>s m<span class="_2 blank"></span>olécul<span class="_1 blank"></span>a<span class="_0 blank"> </span>s pr<span class="_0 blank"> </span>opo<span class="_1 blank"></span>sta<span class="_0 blank"> </span>s:<span class="ff1"> M1 </span><span class="ws3">e</span><span class="ff1"> M2</span><span class="ls7"> <span class="_1f blank"></span>.............................. <span class="_1f blank"></span>85 </span></div><div class="t m0 x7 h6 y3a ff3 fs0 fc0 sc0 ls1 ws1"> </div><div class="t m0 x7 h9 y7a ff3 fs3 fc0 sc0 ls2 ws1"> <span class="fs0 ls1"> </span></div></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div>
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