<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg1.png" alt="Pré-visualização de imagem de arquivo"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls17 ws0">F<span class="blank _0"></span>ARMA<span class="blank _1"></span>COL<span class="blank _2"></span>OGIA</div><div class="t m1 x0 h3 y2 ff1 fs1 fc0 sc0 ls17">-</div><div class="t m2 x2 h4 y3 ff1 fs2 fc0 sc0 ls0 ws1">intr<span class="blank _1"></span>odução</div><div class="t m3 x3 h5 y4 ff2 fs3 fc0 sc0 ls18 ws2">conceitos</div><div class="t m4 x4 h6 y5 ff2 fs4 fc0 sc0 ls19 ws3">básicos</div><div class="t m5 x5 h7 y6 ff2 fs5 fc0 sc0 ls17">:</div><div class="t m6 x6 h8 y7 ff1 fs6 fc0 sc0 ls1 ws4">F<span class="blank _2"></span>ARMACO<span class="blank _2"></span></div><div class="t m7 x7 h9 y8 ff1 fs7 fc0 sc0 ls1a">CINÉTICA</div><div class="t m8 x8 ha y9 ff1 fs8 fc0 sc0 ls1b">VS</div><div class="t m9 x9 hb ya ff1 fs9 fc0 sc0 ls2 ws5">F<span class="blank _2"></span>ARMACO<span class="blank _2"></span></div><div class="t ma xa hc yb ff1 fsa fc0 sc0 ls3 ws6">DINÂMICA</div><div class="t mb xb hd yc ff2 fsb fc0 sc0 ls1c ws7">caminho</div><div class="t mc xc he yd ff1 fsc fc0 sc0 ls4 ws8">que</div><div class="t md xd hf ye ff2 fsd fc0 sc0 ls17">o</div><div class="t me xe h10 yf ff1 fse fc0 sc0 ls5 ws9">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t mf xf h11 y10 ff2 fsf fc0 sc0 ls1d wsa">percorre</div><div class="t m10 x10 h12 y11 ff1 fs10 fc0 sc0 ls1e wsb">Princípios</div><div class="t m11 x11 h13 y12 ff2 fs11 fc0 sc0 ls1f wsc">básicos</div><div class="t m12 x12 h14 y13 ff2 fs12 fc0 sc0 ls20">do</div><div class="t m13 x13 h15 y14 ff1 fs13 fc0 sc0 ls6 wsd">funcionamento</div><div class="t m14 x14 h16 y15 ff2 fs14 fc0 sc0 ls21">desde</div><div class="t m15 x15 h17 y16 ff2 fs15 fc0 sc0 ls17">o</div><div class="t m16 x16 h18 y17 ff2 fs16 fc0 sc0 ls22 wse">momento</div><div class="t m17 x5 h19 y18 ff2 fs17 fc0 sc0 ls23">que</div><div class="t m18 x17 h1a y19 ff2 fs18 fc0 sc0 ls24">entra</div><div class="t m19 x18 h1b y1a ff2 fs19 fc0 sc0 ls25">no</div><div class="t m1a x19 h1c y1b ff2 fs1a fc0 sc0 ls26 wsf">corpo</div><div class="t m1b x1a h1d y1c ff2 fs1b fc0 sc0 ls27 ws10">dos</div><div class="t m1c x1b h1e y1d ff1 fs1c fc0 sc0 ls7 ws11">f<span class="blank _3"></span>ármacos<span class="blank _3"></span></div><div class="t m1d x1c h1f y1e ff2 fs1d fc0 sc0 ls17">.</div><div class="t m1e x1d h20 y1f ff2 fs1e fc0 sc0 ls28 ws12">até</div><div class="t m1f x1e h21 y20 ff2 fs1f fc0 sc0 ls17">o</div><div class="t m20 x1f h22 y21 ff2 fs20 fc0 sc0 ls29 ws13">momento</div><div class="t m21 x20 h23 y22 ff2 fs21 fc0 sc0 ls2a">que</div><div class="t m22 x7 h24 y23 ff2 fs22 fc0 sc0 ls17">é</div><div class="t m23 x17 h25 y24 ff2 fs23 fc0 sc0 ls2b ws14">eliminado</div><div class="t m24 x19 h26 y25 ff2 fs24 fc0 sc0 ls17">.</div><div class="t m25 x21 h27 y26 ff1 fs25 fc0 sc0 ls17">{</div><div class="t m26 x22 h28 y27 ff1 fs26 fc0 sc0 ls17">1</div><div class="t m27 x23 h29 y28 ff2 fs27 fc0 sc0 ls17">O</div><div class="t m28 x24 h2a y29 ff1 fs28 fc0 sc0 ls8 ws15">que</div><div class="t m29 x25 h2b y2a ff2 fs29 fc0 sc0 ls17">o</div><div class="t m2a x26 h2c y2b ff2 fs2a fc0 sc0 ls2c ws16">corpo</div><div class="t m2b x17 h2d y2c ff2 fs2b fc0 sc0 ls2d ws17">faz</div><div class="t m2c x27 h2e y2d ff2 fs2c fc0 sc0 ls17">O</div><div class="t m2d x28 h2f y2e ff2 fs2d fc0 sc0 ls2e">que</div><div class="t m2e x29 h30 y2f ff2 fs2e fc0 sc0 ls17">o</div><div class="t m2f x1c h31 y30 ff1 fs2f fc0 sc0 ls9 ws18">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m30 x2a h32 y31 ff2 fs30 fc0 sc0 ls2f ws19">faz</div><div class="t m31 x2b h33 y32 ff2 fs31 fc0 sc0 ls30">com</div><div class="t m32 x2c h34 y33 ff2 fs32 fc0 sc0 ls17">o</div><div class="t m33 x2d h35 y34 ff1 fs33 fc0 sc0 lsa ws1a">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m34 x2e h36 y35 ff2 fs34 fc0 sc0 ls31">com</div><div class="t m35 x2f h37 y36 ff2 fs35 fc0 sc0 ls17">o</div><div class="t m36 x22 h38 y37 ff2 fs36 fc0 sc0 ls32 ws1b">corpo</div><div class="t m37 x13 h39 y38 ff2 fs37 fc0 sc0 ls17">.</div><div class="t m38 x3 h3a y39 ff2 fs38 fc0 sc0 ls17">*</div><div class="t m39 x30 h3b y3a ff2 fs39 fc0 sc0 ls33 ws1c">MEDICAMENT<span class="blank _3"></span>O</div><div class="t m3a x31 h3c y3b ff2 fs3a fc0 sc0 ls17">=</div><div class="t m3b x7 h3d y3c ff2 fs3b fc0 sc0 ls34 ws1d">DROGA</div><div class="t m3c x18 h3e y3d ff2 fs3c fc0 sc0 ls17">=</div><div class="t m3d x32 h3f y3e ff2 fs3d fc0 sc0 ls35 ws1e">FÁ R M AC O</div><div class="t m3e x33 h40 y3f ff1 fs3e fc0 sc0 lsb ws1f">COMP<span class="blank _2"></span>ARTIMENT<span class="blank _2"></span>OS</div><div class="t m3f x34 h41 y40 ff1 fs3f fc0 sc0 ls17">/</div><div class="t m40 x35 h42 y41 ff1 fs40 fc0 sc0 ls36">d)</div><div class="t m41 x36 h43 y42 ff1 fs41 fc0 sc0 ls37">01</div><div class="t m42 x37 h44 y43 ff1 fs42 fc0 sc0 ls38 ws20">Intersticial</div><div class="t m43 x23 h45 y44 ff1 fs43 fc0 sc0 lsc ws21">Intravascular</div><div class="t m44 x38 h46 y45 ff1 fs44 fc0 sc0 ls17">)</div><div class="t m45 x39 h47 y46 ff1 fs45 fc0 sc0 ls17">)</div><div class="t m46 x34 h48 y47 ff1 fs46 fc0 sc0 ls17">"</div><div class="t m47 x2 h49 y48 ff1 fs47 fc0 sc0 ls39">ol</div><div class="t m48 x3a h4a y49 ff1 fs48 fc0 sc0 ls3a">ol</div><div class="t m49 x3b h4b y4a ff1 fs49 fc0 sc0 ls17">l</div><div class="t m4a x3c h4c y4b ff1 fs4a fc0 sc0 ls17">l</div><div class="t m4b x3d h4d y4c ff1 fs4b fc0 sc0 ls17">o</div><div class="t m4c x3e h4e y4d ff1 fs4c fc0 sc0 ls17">01</div><div class="t m4d x5 h4f y4e ff1 fs4d fc0 sc0 ls17">/</div><div class="t m4e x32 h50 y4f ff1 fs4e fc0 sc0 ls17">/</div><div class="t m4f x3f h51 y50 ff1 fs4f fc0 sc0 ls17">/</div><div class="t m50 x8 h52 y51 ff1 fs50 fc0 sc0 ls17">(</div><div class="t m51 x40 h53 y52 ff1 fs51 fc0 sc0 lsd ws22">Intracelular</div><div class="t m52 x19 h54 y53 ff1 fs52 fc0 sc0 ls17">e</div><div class="t m53 x41 h55 y54 ff1 fs53 fc0 sc0 ls17">o</div><div class="t m54 x42 h56 y55 ff1 fs54 fc0 sc0 ls17">}</div><div class="t m55 x43 h57 y56 ff1 fs55 fc0 sc0 ls17">l</div><div class="t m56 x44 h58 y57 ff1 fs56 fc0 sc0 lse ws23">Çt<span class="blank _1"></span>apaadat<span class="blank _3"></span>armacoeinéticavias</div><div class="t m57 x45 h59 y58 ff2 fs57 fc0 sc0 ls3b">DE</div><div class="t m58 x46 h5a y59 ff1 fs58 fc0 sc0 lsf ws24">ADMINISTRA<span class="blank _3"></span>ÇÃO</div><div class="t m59 x1d h5b y5a ff2 fs59 fc0 sc0 ls3c">1-</div><div class="t m5a x47 h5c y5b ff1 fs5a fc0 sc0 ls10 ws25">Absor<span class="blank _3"></span>ção</div><div class="t m5b x48 h5d y5c ff2 fs5b fc0 sc0 ls17">-</div><div class="t m5c x49 h5e y5d ff2 fs5c fc0 sc0 ls3d">vuiaarae</div><div class="t m5d x48 h5f y5e ff2 fs5d fc0 sc0 ls17">-</div><div class="t m5e x49 h60 y5f ff2 fs5e fc0 sc0 ls3e ws26">Sublingual</div><div class="t m5f x4a h61 y60 ff1 fs5f fc0 sc0 ls17">}</div><div class="t m60 x10 h62 y61 ff2 fs60 fc0 sc0 ls11 ws27">ENTERAIS</div><div class="t m61 x1d h63 y62 ff2 fs61 fc0 sc0 ls3f">2-</div><div class="t m62 x47 h64 y63 ff1 fs62 fc0 sc0 ls12 ws28">Distribuição</div><div class="t m63 x48 h65 y64 ff2 fs63 fc0 sc0 ls17">-</div><div class="t m64 x49 h66 y65 ff2 fs64 fc0 sc0 ls40 ws29">Reta</div><div class="t m65 x1d h67 y66 ff2 fs65 fc0 sc0 ls41">3.</div><div class="t m66 x47 h68 y67 ff1 fs66 fc0 sc0 ls13 ws2a">Metabolismo</div><div class="t m67 x48 h69 y68 ff2 fs67 fc0 sc0 ls17">-</div><div class="t m68 x4b h6a y69 ff2 fs68 fc0 sc0 ls42 ws2b">Pare n t e r a l</div><div class="t m69 x4c h6b y6a ff2 fs69 fc0 sc0 ls17">-</div><div class="t m6a x1b h6c y6b ff2 fs6a fc0 sc0 ls17">%</div><div class="t m6b x4d h6d y6c ff2 fs6b fc0 sc0 ls17">"</div><div class="t m6c x4e h6e y6d ff2 fs6c fc0 sc0 ls17">-</div><div class="t m6d x4f h6f y6e ff2 fs6d fc0 sc0 ls43 ws2c">óssea</div><div class="t m6e x50 h70 y6f ff2 fs6e fc0 sc0 ls17">.</div><div class="t m6f x51 h71 y70 ff1 fs6f fc0 sc0 ls17">}</div><div class="t m70 x52 h72 y71 ff2 fs70 fc0 sc0 ls44 ws2d">%Eaisw<span class="blank _2"></span>.no</div><div class="t m71 x53 h73 y72 ff2 fs71 fc0 sc0 ls17">,</div><div class="t m72 x1d h74 y73 ff2 fs72 fc0 sc0 ls45">4-</div><div class="t m73 x54 h75 y74 ff2 fs73 fc0 sc0 ls46 ws2e">Excr<span class="blank _3"></span>eção</div><div class="t m74 x48 h76 y75 ff2 fs74 fc0 sc0 ls17">:</div><div class="t m75 x4b h77 y76 ff1 fs75 fc0 sc0 ls14 ws2f">Êp%%Íp</div><div class="t m76 x55 h78 y77 ff2 fs76 fc0 sc0 ls47">iieeiãsi</div><div class="t m77 x4c h79 y78 ff2 fs77 fc0 sc0 ls48">de</div><div class="t m78 x4c h7a y79 ff2 fs78 fc0 sc0 ls17">{</div><div class="t m79 x4a h7b y7a ff2 fs79 fc0 sc0 ls15 ws30">Ígnea</div><div class="t m7a x56 h7c y7b ff2 fs7a fc0 sc0 ls16 ws31">nasal</div><div class="t m7b x57 h7d y7c ff2 fs7b fc0 sc0 ls17">,</div><div class="t m7c x58 h7e y7d ff2 fs7c fc0 sc0 ls49 ws32">vagi n a</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg2.png" alt="Pré-visualização de imagem de arquivo"><div class="t m7d x6 h7f y7e ff1 fs7d fc0 sc0 ls17 ws34">mf<span class="blank _4"></span>armaqcinek.<span class="blank _4"></span>com</div><div class="t m7e x59 h80 y7f ff1 fs7e fc0 sc0 ls17">A</div><div class="t m7f x48 h81 y80 ff1 fs7f fc0 sc0 ls4a ws35">BSORÇA<span class="blank _3"></span>O</div><div class="t m80 x1b h82 y81 ff3 fs80 fc0 sc0 ls17">→</div><div class="t m81 x5a h83 y82 ff2 fs81 fc0 sc0 ls6e ws36">fár m a c o s</div><div class="t m82 x5b h84 y83 ff1 fs82 fc0 sc0 ls6f">lipofílicas</div><div class="t m83 x5c h85 y84 ff1 fs83 fc0 sc0 ls70">19</div><div class="t m84 x5d h86 y85 ff1 fs84 fc0 sc0 ls4b ws37">Etapa</div><div class="t m85 x4e h87 y86 ff2 fs85 fc0 sc0 ls4c ws38">são</div><div class="t m86 x5e h88 y87 ff2 fs86 fc0 sc0 ls17">t</div><div class="t m87 x5f h89 y88 ff2 fs87 fc0 sc0 ls71 ws39">absorvidos</div><div class="t m88 x60 h8a y89 ff2 fs88 fc0 sc0 ls72 ws3a">por</div><div class="t m89 x61 h8b y8a ff2 fs89 fc0 sc0 ls4d ws3b">causa</div><div class="t m8a x62 h8c y8b ff2 fs8a fc0 sc0 ls73">da</div><div class="t m8b x63 h8d y8c ff2 fs8b fc0 sc0 ls4e ws3c">bicama</div><div class="t m8c x64 h8e y8d ff2 fs8c fc0 sc0 ls74">da</div><div class="t m8d x65 h8f y8e ff2 fs8d fc0 sc0 ls75 ws3d">lipídica</div><div class="t m8e x66 h90 y8f ff2 fs8e fc0 sc0 ls4f ws3e">das</div><div class="t m8f x1d h91 y90 ff4 fs8f fc0 sc0 ls17">②</div><div class="t m90 x67 h92 y91 ff1 fs90 fc0 sc0 ls76 ws3f">ta<span class="blank _5"></span>xa<span class="blank _5"></span>r</div><div class="t m91 x22 h93 y92 ff2 fs91 fc0 sc0 ls17">"</div><div class="t m92 x5e h94 y93 ff2 fs92 fc0 sc0 ls17">"</div><div class="t m93 x68 h95 y94 ff2 fs93 fc0 sc0 ls17">"</div><div class="t m94 x69 h96 y95 ff2 fs94 fc0 sc0 ls17">"</div><div class="t m95 x6a h97 y96 ff2 fs95 fc0 sc0 ls77">se</div><div class="t m96 x6b h98 y97 ff5 fs96 fc0 sc0 ls17">↳</div><div class="t m97 x6c h99 y98 ff1 fs97 fc0 sc0 ls78">joelho</div><div class="t m98 x6d h9a y99 ff1 fs98 fc0 sc0 ls79">:*</div><div class="t m99 x6e h9b y9a ff1 fs99 fc0 sc0 ls7a">:[</div><div class="t m9a x6f h9c y9b ff2 fs9a fc0 sc0 ls7b">do</div><div class="t m9b x67 h9d y9c ff1 fs9b fc0 sc0 ls7c ws40">tét a n o</div><div class="t m9c x2f h9e y9d ff2 fs9c fc0 sc0 ls17">.</div><div class="t m9d x60 h9f y9e ff2 fs9d fc0 sc0 ls7d ws41">devido</div><div class="t m9e x70 ha0 y9f ff2 fs9e fc0 sc0 ls7e">as</div><div class="t m9f x71 ha1 ya0 ff2 fs9f fc0 sc0 ls17">-</div><div class="t ma0 x72 ha2 ya1 ff2 fsa0 fc0 sc0 ls7f">vilosidades</div><div class="t ma1 x73 ha3 ya2 ff2 fsa1 fc0 sc0 ls17">-</div><div class="t ma2 x6 ha4 ya3 ff1 fsa2 fc0 sc0 ls17">F</div><div class="t ma3 x74 ha5 ya4 ff1 fsa3 fc0 sc0 ls17">O</div><div class="t ma4 x3e ha6 ya5 ff1 fsa4 fc0 sc0 ls80">nü</div><div class="t ma5 x75 ha7 ya6 ff2 fsa5 fc0 sc0 ls81 ws42">fo r m e m</div><div class="t ma6 x76 ha8 ya7 ff1 fsa6 fc0 sc0 ls82">:*</div><div class="t ma7 x22 ha9 ya8 ff2 fsa7 fc0 sc0 ls17">.</div><div class="t ma8 x5e haa ya9 ff1 fsa8 fc0 sc0 ls83">:*</div><div class="t ma9 x77 hab yaa ff1 fsa9 fc0 sc0 ls84">.it?Em</div><div class="t maa x1f hac yab ff1 fsaa fc0 sc0 ls17">F</div><div class="t mab x78 had yac ff1 fsab fc0 sc0 ls17">O</div><div class="t mac x79 hae yad ff2 fsac fc0 sc0 ls17">-</div><div class="t mad x42 haf yae ff1 fsad fc0 sc0 ls50 ws43">Difusão</div><div class="t mae x7a hb0 yaf ff2 fsae fc0 sc0 ls85 ws44">passiv<span class="blank _3"></span>a</div><div class="t maf x7b hb1 yb0 ff1 fsaf fc0 sc0 ls17">}</div><div class="t mb0 x7c hb2 yb1 ff2 fsb0 fc0 sc0 ls86">sem</div><div class="t mb1 x7d hb3 yb2 ff1 fsb1 fc0 sc0 ls51 ws45">gast<span class="blank _3"></span>o</div><div class="t mb2 x63 hb4 yb3 ff2 fsb2 fc0 sc0 ls87">de</div><div class="t mb3 x13 hb5 yb4 ff1 fsb3 fc0 sc0 ls52 ws46">ener<span class="blank _3"></span>gia</div><div class="t mb4 x7e hb6 yb5 ff1 fsb4 fc0 sc0 ls88">jr</div><div class="t mb5 x7f hb7 yb6 ff2 fsb5 fc0 sc0 ls17">.</div><div class="t mb6 x78 hb8 yb7 ff1 fsb6 fc0 sc0 ls17">%</div><div class="t mb7 x80 hb9 yb8 ff2 fsb7 fc0 sc0 ls17">-</div><div class="t mb8 x79 hba yb9 ff2 fsb8 fc0 sc0 ls17">-</div><div class="t mb9 x81 hbb yba ff1 fsb9 fc0 sc0 ls53 ws47">minoria</div><div class="t mba x82 hbc ybb ff1 fsba fc0 sc0 ls89">:*</div><div class="t mbb x37 hbd ybc ff1 fsbb fc0 sc0 ls8a">:p</div><div class="t mbc x27 hbe ybd ff1 fsbc fc0 sc0 ls54 ws48">;%÷÷</div><div class="t mbd x4f hbf ybe ff1 fsbd fc0 sc0 ls17">:</div><div class="t mbe x25 hc0 ybf ff1 fsbe fc0 sc0 ls17">O</div><div class="t mbf x83 hc1 yc0 ff5 fsbf fc0 sc0 ls17">↳</div><div class="t mc0 x84 hc2 yc1 ff1 fsc0 fc0 sc0 ls55 ws49">Bomba</div><div class="t mc1 x85 hc3 yc2 ff2 fsc1 fc0 sc0 ls8b">de</div><div class="t mc2 x86 hc4 yc3 ff2 fsc2 fc0 sc0 ls8c ws4a">AT P</div><div class="t mc3 x87 hc5 yc4 ff1 fsc3 fc0 sc0 ls17">{</div><div class="t mc4 x88 hc6 yc5 ff2 fsc4 fc0 sc0 ls17">(</div><div class="t mc5 x89 hc7 yc6 ff2 fsc5 fc0 sc0 ls8d">com</div><div class="t mc6 x8a hc8 yc7 ff2 fsc6 fc0 sc0 ls8e ws4b">gasto</div><div class="t mc7 x12 hc9 yc8 ff2 fsc7 fc0 sc0 ls8f">de</div><div class="t mc8 x52 hca yc9 ff2 fsc8 fc0 sc0 ls90 ws4c">energia</div><div class="t mc9 x8b hcb yca ff2 fsc9 fc0 sc0 ls17">!</div><div class="t mca x53 hcc ycb ff2 fsca fc0 sc0 ls17">)</div><div class="t mcb x6 hcd ycc ff1 fscb fc0 sc0 ls56 ws4d">f<span class="blank _3"></span>ármaco</div><div class="t mcc xd hce ycd ff2 fscc fc0 sc0 ls91">do</div><div class="t mcd xe hcf yce ff2 fscd fc0 sc0 ls92 ws4e">fár m a c o</div><div class="t mce x8c hd0 ycf ff2 fsce fc0 sc0 ls57 ws4f">tem</div><div class="t mcf xd hd1 yd0 ff2 fscf fc0 sc0 ls93">que</div><div class="t md0 x8d hd2 yd1 ff2 fsd0 fc0 sc0 ls94 ws50">atraves<span class="blank _3"></span>sar</div><div class="t md1 x45 hd3 yd2 ff2 fsd1 fc0 sc0 ls17">-</div><div class="t md2 x8e hd4 yd3 ff2 fsd2 fc0 sc0 ls17">-</div><div class="t md3 x8f hd5 yd4 ff2 fsd3 fc0 sc0 ls95 ws51">ãsãmoineranaão</div><div class="t md4 x90 hd6 yd5 ff2 fsd4 fc0 sc0 ls17">-</div><div class="t md5 x4f hd7 yd6 ff1 fsd5 fc0 sc0 ls58 ws52">madahiaioi</div><div class="t md6 x91 hd8 yd7 ff1 fsd6 fc0 sc0 ls96">:#</div><div class="t md7 x92 hd9 yd8 ff2 fsd7 fc0 sc0 ls17">÷</div><div class="t md8 x93 hda yd9 ff2 fsd8 fc0 sc0 ls17">;</div><div class="t md9 x8f hdb yda ff2 fsd9 fc0 sc0 ls97">pp</div><div class="t mda x5 hdc ydb ff2 fsda fc0 sc0 ls98 ws53">chegar</div><div class="t mdb x94 hdd ydc ff2 fsdb fc0 sc0 ls99">ao</div><div class="t mdc x95 hde ydd ff2 fsdc fc0 sc0 ls9a ws54">sangue</div><div class="t mdd x96 hdf yde ff2 fsdd fc0 sc0 ls17">¥</div><div class="t mde x45 he0 ydf ff2 fsde fc0 sc0 ls17">t</div><div class="t mdf x43 he1 ye0 ff2 fsdf fc0 sc0 ls17">t</div><div class="t me0 x97 he2 ye1 ff2 fse0 fc0 sc0 ls17">t</div><div class="t me1 x82 he3 ye2 ff2 fse1 fc0 sc0 ls17">t</div><div class="t me2 x98 he4 ye3 ff2 fse2 fc0 sc0 ls17">t</div><div class="t me3 x4c he5 ye4 ff2 fse3 fc0 sc0 ls17">t</div><div class="t me4 x99 he6 ye5 ff2 fse4 fc0 sc0 ls17">t</div><div class="t me5 x83 he7 ye6 ff2 fse5 fc0 sc0 ls17">t</div><div class="t me6 x1a he8 ye7 ff2 fse6 fc0 sc0 ls17">t</div><div class="t me7 x71 he9 ye8 ff2 fse7 fc0 sc0 ls17">t</div><div class="t me8 x7c hea ye9 ff2 fse8 fc0 sc0 ls17">t</div><div class="t me9 x75 heb yea ff2 fse9 fc0 sc0 ls17">t</div><div class="t mea x1b hec yeb ff2 fsea fc0 sc0 ls17">t</div><div class="t meb x89 hed yec ff2 fseb fc0 sc0 ls17">t</div><div class="t mec x9a hee yed ff2 fsec fc0 sc0 ls17">t</div><div class="t med x76 hef yee ff2 fsed fc0 sc0 ls17">t</div><div class="t mee x8a hf0 yef ff2 fsee fc0 sc0 ls17">t</div><div class="t mef x9b hf1 yf0 ff2 fsef fc0 sc0 ls9b">ttt</div><div class="t mf0 x9c hf2 yf1 ff2 fsf0 fc0 sc0 ls17">t</div><div class="t mf1 x13 hf3 yf2 ff2 fsf1 fc0 sc0 ls17">t</div><div class="t mf2 x5b hf4 yf3 ff2 fsf2 fc0 sc0 ls17">t</div><div class="t mf3 x64 hf5 yf4 ff2 fsf3 fc0 sc0 ls17">ç</div><div class="t mf4 x3e hf6 yf5 ff1 fsf4 fc0 sc0 ls17">i</div><div class="t mf5 x3e hf7 yf6 ff2 fsf5 fc0 sc0 ls17">+</div><div class="t mf6 x82 hf8 yf7 ff2 fsf6 fc0 sc0 ls17">-</div><div class="t mf7 x9d hf9 yf8 ff2 fsf7 fc0 sc0 ls17">-</div><div class="t mf8 x9 hfa yf9 ff2 fsf8 fc0 sc0 ls17">-</div><div class="t mf9 x1a hfb yfa ff2 fsf9 fc0 sc0 ls17">-</div><div class="t mfa x9e hfc yfb ff2 fsfa fc0 sc0 ls17">-</div><div class="t mfb x75 hfd yfc ff2 fsfb fc0 sc0 ls17">-</div><div class="t mfc x9f hfe yfd ff2 fsfc fc0 sc0 ls17">-</div><div class="t mfd x28 hff yfe ff2 fsfd fc0 sc0 ls17">-</div><div class="t mfe x11 h100 yff ff2 fsfe fc0 sc0 ls17">-</div><div class="t mff x2f h101 y100 ff2 fsff fc0 sc0 ls17">-</div><div class="t m100 xa0 h102 y101 ff2 fs100 fc0 sc0 ls17">-</div><div class="t m101 x85 h103 y102 ff2 fs101 fc0 sc0 ls17">-</div><div class="t m102 x12 h104 y103 ff2 fs102 fc0 sc0 ls17">-</div><div class="t m103 x9c h105 y104 ff2 fs103 fc0 sc0 ls17">-</div><div class="t m104 xa1 h106 y105 ff2 fs104 fc0 sc0 ls17">-</div><div class="t m105 x64 h107 y106 ff2 fs105 fc0 sc0 ls17">t</div><div class="t m106 x3e h108 y107 ff2 fs106 fc0 sc0 ls17">+</div><div class="t m107 x36 h109 y108 ff2 fs107 fc0 sc0 ls17">+</div><div class="t m108 xa2 h10a y109 ff2 fs108 fc0 sc0 ls17">t</div><div class="t m109 xa3 h10b y10a ff2 fs109 fc0 sc0 ls17">t</div><div class="t m10a xa4 h10c y10b ff2 fs10a fc0 sc0 ls17">t</div><div class="t m10b x55 h10d y10c ff2 fs10b fc0 sc0 ls17">t</div><div class="t m10c x37 h10e y10d ff2 fs10c fc0 sc0 ls17">t</div><div class="t m10d xa5 h10f y10e ff2 fs10d fc0 sc0 ls17">t</div><div class="t m10e x56 h110 y10f ff2 fs10e fc0 sc0 ls17">t</div><div class="t m10f xa6 h111 y110 ff2 fs10f fc0 sc0 ls17">t</div><div class="t m110 xa7 h112 y111 ff2 fs110 fc0 sc0 ls17">t</div><div class="t m111 x75 h113 y112 ff2 fs111 fc0 sc0 ls17">t</div><div class="t m112 x2e h114 y113 ff2 fs112 fc0 sc0 ls17">t</div><div class="t m113 x89 h115 y114 ff2 fs113 fc0 sc0 ls17">t</div><div class="t m114 x28 h116 y115 ff2 fs114 fc0 sc0 ls17">t</div><div class="t m115 x76 h117 y116 ff2 fs115 fc0 sc0 ls17">t</div><div class="t m116 x8a h118 y117 ff2 fs116 fc0 sc0 ls17">t</div><div class="t m117 x62 h119 y118 ff2 fs117 fc0 sc0 ls17">t</div><div class="t m118 x22 h11a y119 ff2 fs118 fc0 sc0 ls17">t</div><div class="t m119 x5e h11b y11a ff2 fs119 fc0 sc0 ls17">t</div><div class="t m11a x12 h11c y11b ff2 fs11a fc0 sc0 ls17">t</div><div class="t m11b x77 h11d y11c ff2 fs11b fc0 sc0 ls17">t</div><div class="t m11c x52 h11e y11d ff2 fs11c fc0 sc0 ls17">t</div><div class="t m11d xa8 h11f y11e ff2 fs11d fc0 sc0 ls17">t</div><div class="t m11e xa9 h120 y11f ff2 fs11e fc0 sc0 ls17">t</div><div class="t m11f x64 h121 y120 ff2 fs11f fc0 sc0 ls17">Í</div><div class="t m120 xaa h122 y121 ff1 fs120 fc0 sc0 ls9c ws55">ÁCI D O S</div><div class="t m121 xab h123 y122 ff2 fs121 fc0 sc0 ls17">:</div><div class="t m122 x2d h124 y123 ff2 fs122 fc0 sc0 ls9d ws56">DO<span class="blank _3"></span>ADORES</div><div class="t m123 xac h125 y124 ff2 fs123 fc0 sc0 ls9e">DE</div><div class="t m124 x3e h126 y125 ff1 fs124 fc0 sc0 ls9f">gú</div><div class="t m125 x8f h127 y126 ff1 fs125 fc0 sc0 lsa0 ws57">PRÓ<span class="blank _1"></span>T<span class="blank _3"></span>ONS</div><div class="t m126 x96 h128 y127 ff1 fs126 fc0 sc0 lsa1">aún</div><div class="t m127 x37 h129 y128 ff2 fs127 fc0 sc0 ls59 ws58">Base</div><div class="t m128 x1a h12a y129 ff2 fs128 fc0 sc0 lsa2">fraca</div><div class="t m129 x1b h12b y12a ff3 fs129 fc0 sc0 ls17">→</div><div class="t m12a x9a h12c y12b ff2 fs12a fc0 sc0 lsa3 ws59">Ionizado</div><div class="t m12b x9a h12d y12c ff2 fs12b fc0 sc0 lsa4">Não</div><div class="t m12c x8a h12e y12d ff2 fs12c fc0 sc0 ls17">-</div><div class="t m12d x4f h12f y12e ff2 fs12d fc0 sc0 lsa5">ionizado</div><div class="t m12e xaa h130 y12f ff2 fs12e fc0 sc0 lsa6 ws5a">BASES</div><div class="t m12f x4 h131 y130 ff2 fs12f fc0 sc0 ls17">:</div><div class="t m130 xad h132 y131 ff1 fs130 fc0 sc0 ls5a ws5b">RECEPT<span class="blank _1"></span>ORES</div><div class="t m131 xae h133 y132 ff2 fs131 fc0 sc0 lsa7">DE</div><div class="t m132 xaf h134 y133 ff1 fs132 fc0 sc0 lsa8 ws5c">PRO<span class="blank _1"></span>T<span class="blank _3"></span>ONS</div><div class="t m133 x4b h135 y134 ff1 fs133 fc0 sc0 lsa9">PH</div><div class="t m134 xb0 h136 y135 ff1 fs134 fc0 sc0 ls17">é</div><div class="t m135 x55 h137 y136 ff2 fs135 fc0 sc0 ls17">a</div><div class="t m136 x4a h138 y137 ff1 fs136 fc0 sc0 lsaa">acidez</div><div class="t m137 xb1 h139 y138 ff1 fs137 fc0 sc0 lsab">do</div><div class="t m138 x62 h13a y139 ff2 fs138 fc0 sc0 lsac">meio</div><div class="t m139 xb2 h13b y13a ff1 fs139 fc0 sc0 lsad">aquoso</div><div class="t m13a xb3 h13c y13b ff2 fs13a fc0 sc0 ls17">.</div><div class="t m13b x4b h13d y13c ff1 fs13b fc0 sc0 lsae">pka</div><div class="t m13c xb4 h13e y13d ff1 fs13c fc0 sc0 ls17">é</div><div class="t m13d x9d h13f y13e ff2 fs13d fc0 sc0 ls17">a</div><div class="t m13e xb5 h140 y13f ff1 fs13e fc0 sc0 lsaf">acidez</div><div class="t m13f xb6 h141 y140 ff1 fs13f fc0 sc0 lsb0">da</div><div class="t m140 x22 h142 y141 ff1 fs140 fc0 sc0 ls5b ws5d">substância</div><div class="t m141 xa2 h143 y142 ff2 fs141 fc0 sc0 lsb1">Se</div><div class="t m142 xb0 h144 y143 ff2 fs142 fc0 sc0 ls5c ws5e">pka</div><div class="t m143 xb7 h145 y144 ff2 fs143 fc0 sc0 ls17">L</div><div class="t m144 x58 h146 y145 ff2 fs144 fc0 sc0 ls17">=</div><div class="t m145 x99 h147 y146 ff2 fs145 fc0 sc0 ls17">t</div><div class="t m146 x83 h148 y147 ff2 fs146 fc0 sc0 ls5d ws5f">acidez</div><div class="t m147 xb8 h149 y148 ff2 fs147 fc0 sc0 ls17">A</div><div class="t m148 xb9 h14a y149 ff2 fs148 fc0 sc0 lsb2 ws60">for m a</div><div class="t m149 x21 h14b y14a ff2 fs149 fc0 sc0 lsb3 ws61">profanada</div><div class="t m14a xba h14c y14b ff2 fs14a fc0 sc0 ls17">(</div><div class="t m14b xbb h14d y14c ff2 fs14b fc0 sc0 ls5e ws62">neutra</div><div class="t m14c xbc h14e y14d ff2 fs14c fc0 sc0 ls17">)</div><div class="t m14d x33 h14f y14e ff2 fs14d fc0 sc0 ls17 ws63">aüão</div><div class="t m14e xbd h150 y14f ff4 fs14e fc0 sc0 ls17">④</div><div class="t m14f x1 h151 y150 ff6 fs14f fc0 sc0 ls17">󲍻</div><div class="t m150 x74 h152 y151 ff1 fs150 fc0 sc0 lsb4">a-t-iiiiiiiii.io</div><div class="t m151 xbe h153 y152 ff2 fs151 fc0 sc0 ls17">"</div><div class="t m152 xbf h154 y153 ff2 fs152 fc0 sc0 ls17">"</div><div class="t m153 x3 h155 y154 ff2 fs153 fc0 sc0 ls5f ws64">base</div><div class="t m154 xc0 h156 y155 ff6 fs154 fc0 sc0 ls17">󲍻</div><div class="t m155 x21 h157 y156 ff2 fs155 fc0 sc0 lsb5">Bt</div><div class="t m156 xaf h158 y157 ff2 fs156 fc0 sc0 lsb6">Ht</div><div class="t m157 xc1 h159 y158 ff3 fs157 fc0 sc0 ls17">→</div><div class="t m158 x45 h15a y159 ff2 fs158 fc0 sc0 lsb7 ws65">Te m</div><div class="t m159 x98 h15b y15a ff1 fs159 fc0 sc0 lsb8">que</div><div class="t m15a xc2 h15c y15b ff2 fs15a fc0 sc0 lsb9">ser</div><div class="t m15b xc3 h15d y15c ff2 fs15b fc0 sc0 lsba ws66">neutro</div><div class="t m15c x9b h15e y15d ff2 fs15c fc0 sc0 lsbb">pf</div><div class="t m15d x63 h15f y15e ff2 fs15d fc0 sc0 lsbc ws67">não</div><div class="t m15e x5b h160 y15f ff2 fs15e fc0 sc0 lsbd">ser</div><div class="t m15f x7f h161 y160 ff2 fs15f fc0 sc0 ls17">{</div><div class="t m160 xb8 h162 y161 ff5 fs160 fc0 sc0 ls17">↳</div><div class="t m161 xc0 h163 y162 ff2 fs161 fc0 sc0 lsbe ws68">torna</div><div class="t m162 x21 h164 y163 ff2 fs162 fc0 sc0 lsbf ws69">proto</div><div class="t m163 xc4 h165 y164 ff2 fs163 fc0 sc0 ls60 ws6a">nada</div><div class="t m164 xc5 h166 y165 ff2 fs164 fc0 sc0 lsc0 ws6b">carregada</div><div class="t m165 xa2 h167 y166 ff1 fs165 fc0 sc0 lsc1 ws6c">re p e l i d o</div><div class="t m166 xc6 h168 y167 ff1 fs166 fc0 sc0 lsc2">pelas</div><div class="t m167 xc7 h169 y168 ff1 fs167 fc0 sc0 ls61 ws6d">car<span class="blank _3"></span>gas</div><div class="t m168 x85 h16a y169 ff2 fs168 fc0 sc0 lsc3">da</div><div class="t m169 x9c h16b y16a ff2 fs169 fc0 sc0 lsc4">membrana</div><div class="t m16a xbd h16c y16b ff2 fs16a fc0 sc0 lsc5">só</div><div class="t m16b x15 h16d y16c ff2 fs16b fc0 sc0 ls62 ws6e">quando</div><div class="t m16c xc8 h16e y16d ff2 fs16c fc0 sc0 lsc6">III.</div><div class="t m16d x24 h16f y16e ff2 fs16d fc0 sc0 ls17">"</div><div class="t m16e xb9 h170 y16f ff2 fs16e fc0 sc0 ls63 ws6f">tica</div><div class="t m16f xc9 h171 y170 ff2 fs16f fc0 sc0 lsc7">da</div><div class="t m170 xb7 h172 y171 ff2 fs170 fc0 sc0 lsc8 ws70">célula</div><div class="t m171 x7b h173 y172 ff2 fs171 fc0 sc0 ls17">.</div><div class="t m172 x14 h174 y173 ff1 fs172 fc0 sc0 lsc9 ws71">Qual</div><div class="t m173 x1 h175 y174 ff1 fs173 fc0 sc0 ls17">é</div><div class="t m174 x25 h176 y175 ff2 fs174 fc0 sc0 ls17">a</div><div class="t m175 x26 h177 y176 ff1 fs175 fc0 sc0 ls64 ws72">fração</div><div class="t m176 xca h178 y177 ff1 fs176 fc0 sc0 lsca">do</div><div class="t m177 x42 h179 y178 ff1 fs177 fc0 sc0 lscb">que</div><div class="t m178 x3e h17a y179 ff1 fs178 fc0 sc0 lscc ws73">fo i</div><div class="t m179 xb7 h17b y17a ff1 fs179 fc0 sc0 ls65 ws74">administrado</div><div class="t m17a xcb h17c y17b ff1 fs17a fc0 sc0 ls66 ws75">vai</div><div class="t m17b xcc h17d y17c ff1 fs17b fc0 sc0 ls67 ws76">ef<span class="blank _1"></span>etivament<span class="blank _3"></span>e</div><div class="t m17c x87 h17e y17d ff1 fs17c fc0 sc0 lscd">chegar</div><div class="t m17d xad h17f y17e ff1 fs17d fc0 sc0 lsce">ao</div><div class="t m17e xcd h180 y17f ff1 fs17e fc0 sc0 ls68 ws77">sangue</div><div class="t m17f x19 h181 y180 ff1 fs17f fc0 sc0 ls17">?</div><div class="t m180 x3c h182 y181 ff1 fs180 fc0 sc0 lscf ws78">BIODISPONIBILID<span class="blank _3"></span>ADE</div><div class="t m181 x9c h183 y182 ff2 fs181 fc0 sc0 ls17">!</div><div class="t m182 xb h184 y183 ff4 fs182 fc0 sc0 ls17">②</div><div class="t m183 xce h185 y184 ff1 fs183 fc0 sc0 ls69 ws79">INTERFERÊNCIAS</div><div class="t m184 x42 h186 y185 ff2 fs184 fc0 sc0 ls17">:</div><div class="t m185 x5c h187 y186 ff2 fs185 fc0 sc0 ls17">-</div><div class="t m186 x2b h188 y187 ff1 fs186 fc0 sc0 lsd0 ws7a">Glicoprot<span class="blank _3"></span>eína</div><div class="t m187 x31 h189 y188 ff2 fs187 fc0 sc0 ls17">G</div><div class="t m188 xba h18a y189 ff2 fs188 fc0 sc0 ls17">(</div><div class="t m189 xcf h18b y18a ff2 fs189 fc0 sc0 lsd1">bombeia</div><div class="t m18a xd0 h18c y18b ff1 fs18a fc0 sc0 ls6a ws7b">f<span class="blank _3"></span>ármacos<span class="blank _3"></span></div><div class="t m18b x3e h18d y18c ff2 fs18b fc0 sc0 lsd2">pl</div><div class="t m18c x8 h18e y18d ff2 fs18c fc0 sc0 lsd3 ws7c">for a</div><div class="t m18d x58 h18f y18e ff2 fs18d fc0 sc0 lsd4">da</div><div class="t m18e x83 h190 y18f ff2 fs18e fc0 sc0 lsd5 ws7d">célula</div><div class="t m18f xd1 h191 y190 ff2 fs18f fc0 sc0 ls17">?</div><div class="t m190 x5c h192 y191 ff2 fs190 fc0 sc0 ls17">-</div><div class="t m191 x2b h193 y192 ff1 fs191 fc0 sc0 ls6b ws7e">Ionização</div><div class="t m192 xd2 h194 y193 ff2 fs192 fc0 sc0 ls17">-</div><div class="t m193 xbb h195 y194 ff2 fs193 fc0 sc0 lsd6 ws7f">Quando</div><div class="t m194 xd3 h196 y195 ff2 fs194 fc0 sc0 ls6c ws80">ocorre</div><div class="t m195 xd4 h197 y196 ff2 fs195 fc0 sc0 lsd7 ws81">ionização</div><div class="t m196 x7a h198 y197 ff2 fs196 fc0 sc0 ls17">,</div><div class="t m197 xd5 h199 y198 ff2 fs197 fc0 sc0 ls17">o</div><div class="t m198 x4c h19a y199 ff7 fs198 fc0 sc0 lsd8 ws82">fár<span class="blank _5"> </span>m a c o</div><div class="t m199 x27 h19b y19a ff2 fs199 fc0 sc0 lsd9">se</div><div class="t m19a xc7 h19c y19b ff2 fs19a fc0 sc0 lsda ws83">torna</div><div class="t m19b x62 h19d y19c ff2 fs19b fc0 sc0 lsdb">mais</div><div class="t m19c x77 h19e y19d ff1 fs19c fc0 sc0 ls6d ws84">HIDROFI.LI#Abt<span class="blank _3"></span>arW<span class="blank _2"></span>oa</div><div class="t m19d x6f h19f y19e ff2 fs19d fc0 sc0 ls17">!</div><div class="t m19e x5c h1a0 y19f ff2 fs19e fc0 sc0 ls17">-</div><div class="t m19f x2b h1a1 y1a0 ff2 fs19f fc0 sc0 lsdc ws85">Alimentação</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg3.png" alt="Pré-visualização de imagem de arquivo"><div class="t m1a0 xd6 h1a2 y1a1 ff2 fs1a0 fc0 sc0 ls17">~</div><div class="t m1a1 x35 h1a3 y1a2 ff3 fs1a1 fc0 sc0 ls17">→</div><div class="t m1a2 xd7 h1a4 y1a3 ff2 fs1a2 fc0 sc0 lsf4 ws86">To r n a</div><div class="t m1a3 xb7 h1a5 y1a4 ff2 fs1a3 fc0 sc0 ls17">o</div><div class="t m1a4 x4a h1a6 y1a5 ff1 fs1a4 fc0 sc0 lsdd ws87">f<span class="blank _3"></span>ármaco</div><div class="t m1a5 xb1 h1a7 y1a6 ff2 fs1a5 fc0 sc0 lsf5">mais</div><div class="t m1a6 x1e h1a8 y1a7 ff1 fs1a6 fc0 sc0 lsde ws88">IONIZA<span class="blank _3"></span>ÇA<span class="blank _3"></span>O</div><div class="t m1a7 x7a h1a9 y1a8 ff2 fs1a7 fc0 sc0 lsf6 ws89">Hidrofílica</div><div class="t m1a8 xd8 h1aa y1a9 ff1 fs1a8 fc0 sc0 ls17">-</div><div class="t m1a9 x18 h1ab y1aa ff2 fs1a9 fc0 sc0 ls17">a</div><div class="t m1aa x2b h1ac y1ab ff2 fs1aa fc0 sc0 lsf7 ws8a">Fá r m a c o</div><div class="t m1ab x78 h1ad y1ac ff2 fs1ab fc0 sc0 lsf8 ws8b">ácido</div><div class="t m1ac x31 h1ae y1ad ff2 fs1ac fc0 sc0 ls17">t</div><div class="t m1ad x7 h1af y1ae ff2 fs1ad fc0 sc0 lsf9 ws8c">Estômago</div><div class="t m1ae xd9 h1b0 y1af ff2 fs1ae fc0 sc0 ls17">-</div><div class="t m1af x2 h1b1 y1b0 ff2 fs1af fc0 sc0 lsfa">Não</div><div class="t m1b0 xd7 h1b2 y1b1 ff2 fs1b0 fc0 sc0 lsfb ws8d">IONIZ</div><div class="t m1b1 xbd h1b3 y1b2 ff2 fs1b1 fc0 sc0 lsfc ws8e">Fá r m a c o</div><div class="t m1b2 xad h1b4 y1b3 ff2 fs1b2 fc0 sc0 lsfd ws8f">básico</div><div class="t m1b3 x7 h1b5 y1b4 ff2 fs1b3 fc0 sc0 ls17">+</div><div class="t m1b4 xcf h1b6 y1b5 ff2 fs1b4 fc0 sc0 lsfe ws90">Intestino</div><div class="t m1b5 xda h1b7 y1b6 ff2 fs1b5 fc0 sc0 ls17">-</div><div class="t m1b6 xdb h1b8 y1b7 ff2 fs1b6 fc0 sc0 ls17">"</div><div class="t m1b7 x45 h1b9 y1b8 ff2 fs1b7 fc0 sc0 ls17">"</div><div class="t m1b8 x77 h1ba y1b9 ff1 fs1b8 fc0 sc0 ls17">{</div><div class="t m1b9 x13 h1bb y1ba ff2 fs1b9 fc0 sc0 ls17 ws91">mv<span class="blank _3"></span>dtsearbsorvido</div><div class="t m1ba xbd h1bc y1bb ff2 fs1ba fc0 sc0 ls17">E</div><div class="t m1bb xdc h1bd y1bc ff1 fs1bb fc0 sc0 ls17">:</div><div class="t m1bc xdd h1be y1bd ff1 fs1bc fc0 sc0 ls17">:</div><div class="t m1bd x1 h1bf y1be ff1 fs1bd fc0 sc0 ls17">:</div><div class="t m1be xc0 h1c0 y1bf ff1 fs1be fc0 sc0 ls17">:</div><div class="t m1bf x2d h1c1 y1c0 ff1 fs1bf fc0 sc0 ls17">:</div><div class="t m1c0 x21 h1c2 y1c1 ff1 fs1c0 fc0 sc0 lsff ws92">:÷÷¥</div><div class="t m1c1 xde h1c3 y1c2 ff1 fs1c1 fc0 sc0 ls100">:*</div><div class="t m1c2 xdf h1c4 y1c3 ff1 fs1c2 fc0 sc0 ls17">:</div><div class="t m1c3 x96 h1c5 y1c4 ff2 fs1c3 fc0 sc0 ls17">a</div><div class="t m1c4 xe0 h1c6 y1c5 ff3 fs1c4 fc0 sc0 ls17">→</div><div class="t m1c5 x1c h1c7 y1c6 ff1 fs1c5 fc0 sc0 lsdf ws93">Ioniza</div><div class="t m1c6 x6b h1c8 y1c7 ff2 fs1c6 fc0 sc0 ls17">!</div><div class="t m1c7 xb h1c9 y1c8 ff1 fs1c7 fc0 sc0 ls101">2°</div><div class="t m1c8 x1f h1ca y1c9 ff1 fs1c8 fc0 sc0 lse0 ws94">etapa</div><div class="t m1c9 xe1 h1cb y1ca ff2 fs1c9 fc0 sc0 ls17">:</div><div class="t m1ca x7e h1cc y1cb ff1 fs1ca fc0 sc0 ls17">-</div><div class="t m1cb x5c h1cd y1cc ff1 fs1cb fc0 sc0 lse1 ws95">DISTRIBUIÇÃ<span class="blank _1"></span>O</div><div class="t m1cc x9d h1ce y1cd ff3 fs1cc fc0 sc0 ls17">→</div><div class="t m1cd x57 h1cf y1ce ff2 fs1cd fc0 sc0 ls17">A</div><div class="t m1ce x27 h1d0 y1cf ff2 fs1ce fc0 sc0 ls102 ws96">distribuição</div><div class="t m1cf x51 h1d1 y1d0 ff2 fs1cf fc0 sc0 ls17">é</div><div class="t m1d0 xe2 h1d2 y1d1 ff2 fs1d0 fc0 sc0 ls103">maior</div><div class="t m1d1 x6b h1d3 y1d2 ff2 fs1d1 fc0 sc0 ls104">em</div><div class="t m1d2 x9d h1d4 y1d3 ff2 fs1d2 fc0 sc0 ls105 ws97">Orgãos</div><div class="t m1d3 xd1 h1d5 y1d4 ff2 fs1d3 fc0 sc0 ls106">ricos</div><div class="t m1d4 x7d h1d6 y1d5 ff2 fs1d4 fc0 sc0 ls107">em</div><div class="t m1d5 xa0 h1d7 y1d6 ff2 fs1d5 fc0 sc0 ls108 ws98">vaso s</div><div class="t m1d6 x13 h1d8 y1d7 ff1 fs1d6 fc0 sc0 lse2 ws99">sanguíneos</div><div class="t m1d7 xe3 h1d9 y1d8 ff2 fs1d7 fc0 sc0 ls17">.</div><div class="t m1d8 x38 h1da y1d9 ff1 fs1d8 fc0 sc0 ls17">|</div><div class="t m1d9 x37 h1db y1da ff1 fs1d9 fc0 sc0 lse3 ws9a">BARREIRA</div><div class="t m1da xdc h1dc y1db ff2 fs1da fc0 sc0 ls17">\</div><div class="t m1db x25 h1dd y1dc ff2 fs1db fc0 sc0 ls17">/</div><div class="t m1dc x5 h1de y1dd ff2 fs1dc fc0 sc0 ls17">V</div><div class="t m1dd xe4 h1df y1de ff2 fs1dd fc0 sc0 ls17">e</div><div class="t m1de x3d h1e0 y1df ff2 fs1de fc0 sc0 ls17">_</div><div class="t m1df x98 h1e1 y1e0 ff1 fs1df fc0 sc0 lse4 ws9b">HEMA<span class="blank _0"></span>T<span class="blank _1"></span>OENCEF<span class="blank _1"></span>ÁLICA</div><div class="t m1e0 x1e h1e2 y1e1 ff2 fs1e0 fc0 sc0 ls17">-</div><div class="t m1e1 x1 h1e3 y1e2 ff1 fs1e1 fc0 sc0 ls109 ws9c">Pa s s a g e m</div><div class="t m1e2 xba h1e4 y1e3 ff2 fs1e2 fc0 sc0 ls10a">do</div><div class="t m1e3 xd6 h1e5 y1e4 ff1 fs1e3 fc0 sc0 lse5 ws9d">f<span class="blank _1"></span>ármaco</div><div class="t m1e4 xe5 h1e6 y1e5 ff2 fs1e4 fc0 sc0 ls17">a</div><div class="t m1e5 xe6 h1e7 y1e6 ff2 fs1e5 fc0 sc0 ls17">L</div><div class="t m1e6 xc0 h1e8 y1e7 ff2 fs1e6 fc0 sc0 ls10b">dos</div><div class="t m1e7 xe1 h1e9 y1e8 ff2 fs1e7 fc0 sc0 ls10c ws9e">tecid<span class="blank _5"> </span>os</div><div class="t m1e8 xa5 h1ea y1e9 ff2 fs1e8 fc0 sc0 ls17">É</div><div class="t m1e9 xc6 h1eb y1ea ff2 fs1e9 fc0 sc0 ls10d ws9f">espessa</div><div class="t m1ea xb1 h1ec y1eb ff2 fs1ea fc0 sc0 ls17">e</div><div class="t m1eb x7d h1ed y1ec ff2 fs1eb fc0 sc0 ls10e wsa0">por</div><div class="t m1ec x62 h1ee y1ed ff2 fs1ec fc0 sc0 ls10f wsa1">isso</div><div class="t m1ed x47 h1ef y1ee ff2 fs1ed fc0 sc0 ls17">-</div><div class="t m1ee xa5 h1f0 y1ef ff2 fs1ee fc0 sc0 ls110 wsa2">tem</div><div class="t m1ef x9e h1f1 y1f0 ff1 fs1ef fc0 sc0 lse6 wsa3">absor<span class="blank _3"></span>ção</div><div class="t m1f0 x2f h1f2 y1f1 ff1 fs1f0 fc0 sc0 lse7 wsa4">dificultada</div><div class="t m1f1 xa9 h1f3 y1f2 ff2 fs1f1 fc0 sc0 ls17">!</div><div class="t m1f2 xb8 h1f4 y1f3 ff2 fs1f2 fc0 sc0 ls17">-</div><div class="t m1f3 x78 h1f5 y1f4 ff2 fs1f3 fc0 sc0 ls17">c</div><div class="t m1f4 x26 h1f6 y1f5 ff2 fs1f4 fc0 sc0 ls17">,</div><div class="t m1f5 x17 h1f7 y1f6 ff2 fs1f5 fc0 sc0 ls17">,</div><div class="t m1f6 x19 h1f8 y1f7 ff2 fs1f6 fc0 sc0 ls17">\</div><div class="t m1f7 x99 h1f9 y1f8 ff1 fs1f7 fc0 sc0 ls111 wsa5">Po r t a n to</div><div class="t m1f8 x9f h1fa y1f9 ff2 fs1f8 fc0 sc0 ls17">o</div><div class="t m1f9 x28 h1fb y1fa ff1 fs1f9 fc0 sc0 lse8 wsa6">f<span class="blank _3"></span>ármaco</div><div class="t m1fa x5f h1fc y1fb ff2 fs1fa fc0 sc0 ls112 wsa7">deve</div><div class="t m1fb xcc h1fd y1fc ff2 fs1fb fc0 sc0 ls113">ser</div><div class="t m1fc x99 h1fe y1fd ff2 fs1fc fc0 sc0 ls114 wsa8">bastante</div><div class="t m1fd x2e h1ff y1fe ff1 fs1fd fc0 sc0 ls115">lipofílico</div><div class="t m1fe x50 h200 y1ff ff2 fs1fe fc0 sc0 ls17">p</div><div class="t m1ff x68 h201 y200 ff2 fs1ff fc0 sc0 ls17">,</div><div class="t m200 x5f h202 y201 ff1 fs200 fc0 sc0 ls116">conseguir</div><div class="t m201 xe7 h203 y202 ff2 fs201 fc0 sc0 ls117 wsa9">atrav<span class="blank _3"></span>essá-la</div><div class="t m202 xe8 h204 y203 ff2 fs202 fc0 sc0 ls17">.</div><div class="t m203 x87 h205 y204 ff1 fs203 fc0 sc0 lse9 wsaa">PRO<span class="blank _1"></span>TEINAS</div><div class="t m204 xe9 h206 y205 ff3 fs204 fc0 sc0 ls17">→</div><div class="t m205 x95 h207 y206 ff1 fs205 fc0 sc0 lsea wsab">Principal</div><div class="t m206 xe5 h208 y207 ff2 fs206 fc0 sc0 ls17">é</div><div class="t m207 x96 h209 y208 ff2 fs207 fc0 sc0 ls17">a</div><div class="t m208 x75 h20a y209 ff1 fs208 fc0 sc0 lseb wsac">DISTRIBUIÇÃ<span class="blank _3"></span>O</div><div class="t m209 x87 h20b y20a ff1 fs209 fc0 sc0 ls118 wsad">PLASMÁ<span class="blank _4"></span>TICA</div><div class="t m20a x7 h20c y20b ff1 fs20a fc0 sc0 ls17">S</div><div class="t m20b x8c h20d y20c ff2 fs20b fc0 sc0 ls119 wsae">ALBUMINA</div><div class="t m20c xe5 h20e y20d ff2 fs20c fc0 sc0 ls17">.</div><div class="t m20d x84 h20f y20e ff2 fs20d fc0 sc0 ls11a wsaf">vol u m e</div><div class="t m20e xea h210 y20f ff2 fs20e fc0 sc0 ls11b">de</div><div class="t m20f x6a h211 y210 ff1 fs20f fc0 sc0 lsec wsb0">distribuição</div><div class="t m210 xeb h212 y211 ff2 fs210 fc0 sc0 ls11c">CVD</div><div class="t m211 xe8 h213 y212 ff2 fs211 fc0 sc0 ls17">)</div><div class="t m212 x5c h214 y213 ff2 fs212 fc0 sc0 ls17">O</div><div class="t m213 x2b h215 y214 ff1 fs213 fc0 sc0 lsed wsb1">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m214 xe1 h216 y215 ff1 fs214 fc0 sc0 ls11d wsb2">pode</div><div class="t m215 xbb h217 y216 ff1 fs215 fc0 sc0 ls11e">ligar</div><div class="t m216 xe4 h218 y217 ff2 fs216 fc0 sc0 ls17">-</div><div class="t m217 xec h219 y218 ff2 fs217 fc0 sc0 ls11f">se</div><div class="t m218 xbf h21a y219 ff2 fs218 fc0 sc0 ls17">a</div><div class="t m219 x34 h21b y21a ff2 fs219 fc0 sc0 ls120">uma</div><div class="t m21a x48 h21c y21b ff2 fs21a fc0 sc0 ls121 wsb3">prot<span class="blank _3"></span>eína</div><div class="t m21b x40 h21d y21c ff2 fs21b fc0 sc0 ls17">e</div><div class="t m21c x2e h21e y21d ff2 fs21c fc0 sc0 ls122">VD</div><div class="t m21d x76 h21f y21e ff2 fs21d fc0 sc0 ls17">=</div><div class="t m21e x9b h220 y21f ff2 fs21e fc0 sc0 ls123 wsb4">Dose</div><div class="t m21f xd8 h221 y220 ff2 fs21f fc0 sc0 ls124 wsb5">torna</div><div class="t m220 xb8 h222 y221 ff2 fs220 fc0 sc0 ls17">-</div><div class="t m221 x24 h223 y222 ff2 fs221 fc0 sc0 ls125">se</div><div class="t m222 x4 h224 y223 ff2 fs222 fc0 sc0 ls126">uma</div><div class="t m223 xd2 h225 y224 ff2 fs223 fc0 sc0 ls127 wsb6">molécula</div><div class="t m224 xec h226 y225 ff2 fs224 fc0 sc0 ls128 wsb7">muito</div><div class="t m225 x2 h227 y226 ff1 fs225 fc0 sc0 ls129 wsb8">grande</div><div class="t m226 x29 h228 y227 ff2 fs226 fc0 sc0 ls17">-</div><div class="t m227 x2f h229 y228 ff1 fs227 fc0 sc0 lsee wsb9">concentração</div><div class="t m228 x6b h22a y229 ff2 fs228 fc0 sc0 ls17">(</div><div class="t m229 x53 h22b y22a ff2 fs229 fc0 sc0 ls12a wsba">sangue</div><div class="t m22a xed h22c y22b ff2 fs22a fc0 sc0 ls17">/</div><div class="t m22b xee h22d y22c ff2 fs22b fc0 sc0 ls12b wsbb">plasma</div><div class="t m22c xef h22e y22d ff1 fs22c fc0 sc0 ls17">)</div><div class="t m22d x5c h22f y22e ff1 fs22d fc0 sc0 lsef wsbc">dificultando</div><div class="t m22e xe1 h230 y22f ff2 fs22e fc0 sc0 ls12c">sua</div><div class="t m22f xf0 h231 y230 ff2 fs22f fc0 sc0 ls12d wsbd">passagem</div><div class="t m230 xd0 h232 y231 ff1 fs230 fc0 sc0 ls12e">pela</div><div class="t m231 xf1 h233 y232 ff2 fs231 fc0 sc0 ls12f">membrana</div><div class="t m232 x5c h234 y233 ff2 fs232 fc0 sc0 ls130">da</div><div class="t m233 x7f h235 y234 ff2 fs233 fc0 sc0 ls131 wsbe">célula</div><div class="t m234 xf2 h236 y235 ff2 fs234 fc0 sc0 ls17">.</div><div class="t m235 x9f h237 y236 ff2 fs235 fc0 sc0 ls17">A</div><div class="t m236 x9a h238 y237 ff2 fs236 fc0 sc0 ls132">VD</div><div class="t m237 x2f h239 y238 ff2 fs237 fc0 sc0 ls17">=</div><div class="t m238 xf3 h23a y239 ff2 fs238 fc0 sc0 ls133">Mais</div><div class="t m239 x9c h23b y23a ff1 fs239 fc0 sc0 lsf0 wsbf">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m23a xe7 h23c y23b ff2 fs23a fc0 sc0 lsf1 wsc0">nos</div><div class="t m23b xf4 h23d y23c ff2 fs23b fc0 sc0 ls134 wsc1">tecido<span class="blank _5"> </span>s</div><div class="t m23c x23 h23e y23d ff2 fs23c fc0 sc0 ls135">TEMPO</div><div class="t m23d x2d h23f y23e ff2 fs23d fc0 sc0 ls136">DE</div><div class="t m23e xd2 h240 y23f ff2 fs23e fc0 sc0 ls137">MEIA</div><div class="t m23f xf5 h241 y240 ff2 fs23f fc0 sc0 ls138 wsc2">VID<span class="blank _3"></span>A</div><div class="t m240 xf6 h242 y241 ff2 fs240 fc0 sc0 ls17">-</div><div class="t m241 xf7 h243 y242 ff2 fs241 fc0 sc0 ls139 wsc3">Te m p o</div><div class="t m242 xf8 h244 y243 ff1 fs242 fc0 sc0 lsf2 wsc4">gasto</div><div class="t m243 xaf h245 y244 ff2 fs243 fc0 sc0 ls13a">pl</div><div class="t m244 xba h246 y245 ff2 fs244 fc0 sc0 ls13b">que</div><div class="t m245 xf9 h247 y246 ff2 fs245 fc0 sc0 ls17">a</div><div class="t m246 xdf h248 y247 ff2 fs246 fc0 sc0 ls13c">F)</div><div class="t m247 x19 h249 y248 ff1 fs247 fc0 sc0 ls13d">plasmática</div><div class="t m248 x6 h24a y249 ff1 fs248 fc0 sc0 lsf3 wsc5">@EaEE.fimmEjjo<span class="blank _6"></span>.<span class="blank _6"></span>or<span class="blank _4"></span>g</div><div class="t m249 xd3 h24b y24a ff2 fs249 fc0 sc0 ls13e wsc6">animar</div><div class="t m24a x16 h24c y24b ff2 fs24a fc0 sc0 ls13f wsc7">Aum e n t a</div><div class="t m24b xc5 h24d y24c ff2 fs24b fc0 sc0 ls140">e)</div><div class="t m24c xe9 h24e y24d ff2 fs24c fc0 sc0 ls17">O</div><div class="t m24d x39 h24f y24e ff2 fs24d fc0 sc0 ls141 wsc8">VDT</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg4.png" alt="Pré-visualização de imagem de arquivo"><div class="t m24e x59 h250 y24f ff1 fs24e fc0 sc0 ls152">39</div><div class="t m24f xfa h251 y250 ff1 fs24f fc0 sc0 ls142 wsc9">ET<span class="blank _4"></span>AP<span class="blank _2"></span>A</div><div class="t m250 xf h252 y251 ff1 fs250 fc0 sc0 ls143 wsca">MÉT<span class="blank _7"></span>ABOSMO</div><div class="t m251 x7e h253 y252 ff1 fs251 fc0 sc0 ls153 wscb">BIODISPONIBILID<span class="blank _1"></span>ADE</div><div class="t m252 xf0 h254 y253 ff1 fs252 fc0 sc0 ls17">t</div><div class="t m253 x87 h255 y254 ff1 fs253 fc0 sc0 ls144 wscc">Dose</div><div class="t m254 xfb h256 y255 ff2 fs254 fc0 sc0 ls154 wscd">administrada</div><div class="t m255 x3d h257 y256 ff2 fs255 fc0 sc0 ls155">de</div><div class="t m256 x87 h258 y257 ff2 fs256 fc0 sc0 ls156">um</div><div class="t m257 x1 h259 y258 ff1 fs257 fc0 sc0 ls145 wsce">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m258 xe9 h25a y259 ff1 fs258 fc0 sc0 ls146 wscf">que</div><div class="t m259 xca h25b y25a ff1 fs259 fc0 sc0 ls157">atinge</div><div class="t m25a xfc h25c y25b ff2 fs25a fc0 sc0 ls17">a</div><div class="t m25b x1f h25d y25c ff1 fs25b fc0 sc0 ls147 wsd0">cir<span class="blank _3"></span>culação</div><div class="t m25c xbb h25e y25d ff2 fs25c fc0 sc0 ls158 wsd1">sistêmica</div><div class="t m25d x3f h25f y25e ff2 fs25d fc0 sc0 ls17">.</div><div class="t m25e x3 h260 y25f ff1 fs25e fc0 sc0 ls148 wsd2">BIO</div><div class="t m25f x1f h261 y260 ff1 fs25f fc0 sc0 ls149 wsd3">TRANSFORMA<span class="blank _1"></span>ÇÃ<span class="blank _3"></span>O</div><div class="t m260 xe h262 y261 ff1 fs260 fc0 sc0 ls17">L</div><div class="t m261 x5c h263 y262 ff2 fs261 fc0 sc0 ls159 wsd4">Serve</div><div class="t m262 x16 h264 y263 ff2 fs262 fc0 sc0 ls17">p</div><div class="t m263 xc h265 y264 ff2 fs263 fc0 sc0 ls17">,</div><div class="t m264 x74 h266 y265 ff2 fs264 fc0 sc0 ls15a wsd5">inativar</div><div class="t m265 xfd h267 y266 ff2 fs265 fc0 sc0 ls17">o</div><div class="t m266 x94 h268 y267 ff1 fs266 fc0 sc0 ls14a wsd6">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m267 xfe h269 y268 ff1 fs267 fc0 sc0 ls15b wsd7">Tr a n s f<span class="blank _8"> </span>o r m á</div><div class="t m268 x2c h26a y269 ff2 fs268 fc0 sc0 ls17">-</div><div class="t m269 xf8 h26b y26a ff2 fs269 fc0 sc0 ls15c">lo</div><div class="t m26a xff h26c y26b ff2 fs26a fc0 sc0 ls15d">de</div><div class="t m26b x8d h26d y26c ff1 fs26b fc0 sc0 ls15e">lipofílico</div><div class="t m26c xd3 h26e y26d ff1 fs26c fc0 sc0 ls15f">pl</div><div class="t m26d x3b h26f y26e ff1 fs26d fc0 sc0 ls14b wsd8">hidr<span class="blank _3"></span>ofílica</div><div class="t m26e x100 h270 y26f ff2 fs26e fc0 sc0 ls17">,</div><div class="t m26f x101 h271 y270 ff2 fs26f fc0 sc0 ls160 wsd9">Fa c i l i t a n d o</div><div class="t m270 xb9 h272 y271 ff2 fs270 fc0 sc0 ls17">,</div><div class="t m271 x4 h273 y272 ff2 fs271 fc0 sc0 ls161 wsda">assim</div><div class="t m272 xe h274 y273 ff2 fs272 fc0 sc0 ls17">,</div><div class="t m273 x8d h275 y274 ff2 fs273 fc0 sc0 ls14c wsdb">sua</div><div class="t m274 x102 h276 y275 ff2 fs274 fc0 sc0 ls162 wsdc">excre ç ã o</div><div class="t m275 x3d h277 y276 ff2 fs275 fc0 sc0 ls17">.</div><div class="t m276 xce h278 y277 ff1 fs276 fc0 sc0 ls163 wsdd">Fa s t</div><div class="t m277 x87 h279 y278 ff1 fs277 fc0 sc0 ls164 wsde">Tr a n s f<span class="blank _8"> </span>o r m a</div><div class="t m278 x103 h27a y279 ff2 fs278 fc0 sc0 ls165">de</div><div class="t m279 xf0 h27b y27a ff1 fs279 fc0 sc0 ls166">lipofílico</div><div class="t m27a xd9 h27c y27b ff2 fs27a fc0 sc0 ls167">em</div><div class="t m27b x5c h27d y27c ff2 fs27b fc0 sc0 ls168 wsdf">polar</div><div class="t m27c x1 h27e y27d ff2 fs27c fc0 sc0 ls17">(</div><div class="t m27d xc h27f y27e ff2 fs27d fc0 sc0 ls169 wse0">hidrofílica</div><div class="t m27e x104 h280 y27f ff2 fs27e fc0 sc0 ls17">)</div><div class="t m27f x17 h281 y280 ff2 fs27f fc0 sc0 ls16a wse1">usando</div><div class="t m280 x19 h282 y281 ff2 fs280 fc0 sc0 ls17">a</div><div class="t m281 x105 h283 y282 ff2 fs281 fc0 sc0 ls16b wse2">citocromo</div><div class="t m282 x78 h284 y283 ff2 fs282 fc0 sc0 ls17">P</div><div class="t m283 xae h285 y284 ff2 fs283 fc0 sc0 ls16c">450</div><div class="t m284 x5 h286 y285 ff2 fs284 fc0 sc0 ls17">.</div><div class="t m285 xb8 h287 y286 ff2 fs285 fc0 sc0 ls17">-</div><div class="t m286 xb9 h288 y287 ff1 fs286 fc0 sc0 ls14d wse3">Redução</div><div class="t m287 x5d h289 y288 ff2 fs287 fc0 sc0 ls17">-</div><div class="t m288 xb9 h28a y289 ff2 fs288 fc0 sc0 ls16d wse4">Oxid<span class="blank _5"> </span>açã<span class="blank _5"> </span>o</div><div class="t m289 x106 h28b y28a ff2 fs289 fc0 sc0 ls17">-</div><div class="t m28a x107 h28c y28b ff2 fs28a fc0 sc0 ls16e wse5">Hidrólise</div><div class="t m28b xdd h28d y28c ff1 fs28b fc0 sc0 ls16f wse6">IF<span class="blank _0"></span>AS.<span class="blank _6"></span>CI</div><div class="t m28c xfc h28e y28d ff1 fs28c fc0 sc0 ls14e wse7">Quando</div><div class="t m28d xf2 h28f y28e ff2 fs28d fc0 sc0 ls17">a</div><div class="t m28e xad h290 y28f ff2 fs28e fc0 sc0 ls170 wse8">fas e</div><div class="t m28f x8d h291 y290 ff2 fs28f fc0 sc0 ls17">1</div><div class="t m290 xbb h292 y291 ff2 fs290 fc0 sc0 ls171 wse9">não</div><div class="t m291 xe4 h293 y292 ff2 fs291 fc0 sc0 ls17">é</div><div class="t m292 xbe h294 y293 ff2 fs292 fc0 sc0 ls172 wsea">suficiente</div><div class="t m293 x4b h295 y294 ff2 fs293 fc0 sc0 ls17">!</div><div class="t m294 x15 h296 y295 ff2 fs294 fc0 sc0 ls17">-</div><div class="t m295 xfb h297 y296 ff1 fs295 fc0 sc0 ls173">Reações</div><div class="t m296 x108 h298 y297 ff2 fs296 fc0 sc0 ls174">de</div><div class="t m297 xcf h299 y298 ff1 fs297 fc0 sc0 ls175">conjugação</div><div class="t m298 xcd h29a y299 ff1 fs298 fc0 sc0 ls176 wseb">GLIUURONIDA<span class="blank _1"></span>ÇÁO</div><div class="t m299 xbb h29b y29a ff2 fs299 fc0 sc0 ls17">é</div><div class="t m29a xde h29c y29b ff2 fs29a fc0 sc0 ls17">a</div><div class="t m29b x8c h29d y29c ff2 fs29b fc0 sc0 ls177">mais</div><div class="t m29c x34 h29e y29d ff2 fs29c fc0 sc0 ls178 wsec">impor tante</div><div class="t m29d xc9 h29f y29e ff2 fs29d fc0 sc0 ls17">.</div><div class="t m29e x38 h2a0 y29f ff2 fs29e fc0 sc0 ls17">(</div><div class="t m29f x104 h2a1 y2a0 ff2 fs29f fc0 sc0 ls179 wsed">adiciona</div><div class="t m2a0 x59 h2a2 y2a1 ff2 fs2a0 fc0 sc0 ls17a wsee">ácido</div><div class="t m2a1 xba h2a3 y2a2 ff2 fs2a1 fc0 sc0 ls17b wsef">uglicurõnico</div><div class="t m2a2 x2 h2a4 y2a3 ff2 fs2a2 fc0 sc0 ls17">)</div><div class="t m2a3 x23 h2a5 y2a4 ff2 fs2a3 fc0 sc0 ls17c wsf0">Fá r m a c o s</div><div class="t m2a4 x108 h2a6 y2a5 ff1 fs2a4 fc0 sc0 ls14f wsf1">que</div><div class="t m2a5 xf5 h2a7 y2a6 ff1 fs2a5 fc0 sc0 ls150 wsf2">possuem</div><div class="t m2a6 x35 h2a8 y2a7 ff2 fs2a6 fc0 sc0 ls17d">0H</div><div class="t m2a7 x41 h2a9 y2a8 ff2 fs2a7 fc0 sc0 ls17">,</div><div class="t m2a8 x30 h2aa y2a9 ff2 fs2a8 fc0 sc0 ls17e">NH</div><div class="t m2a9 x109 h2ab y2aa ff2 fs2a9 fc0 sc0 ls17">2</div><div class="t m2aa x10a h2ac y2ab ff2 fs2aa fc0 sc0 ls17f">ou</div><div class="t m2ab x10b h2ad y2ac ff2 fs2ab fc0 sc0 ls180 wsf3">COOH</div><div class="t m2ac x17 h2ae y2ad ff1 fs2ac fc0 sc0 ls151 wsf4">podem</div><div class="t m2ad x10c h2af y2ae ff2 fs2ad fc0 sc0 ls181">ir</div><div class="t m2ae xd4 h2b0 y2af ff2 fs2ae fc0 sc0 ls182 wsf5">direto</div><div class="t m2af x30 h2b1 y2b0 ff1 fs2af fc0 sc0 ls183">PI</div><div class="t m2b0 x1f h2b2 y2b1 ff2 fs2b0 fc0 sc0 ls17">a</div><div class="t m2b1 x10d h2b3 y2b2 ff1 fs2b1 fc0 sc0 ls184 wsf6">fa s e</div><div class="t m2b2 x10b h2b4 y2b3 ff2 fs2b2 fc0 sc0 ls185">II</div><div class="t m2b3 x10e h2b5 y2b4 ff2 fs2b3 fc0 sc0 ls17">.</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg5.png" alt="Pré-visualização de imagem de arquivo"><div class="t m2b4 xc1 h2b6 y2b5 ff1 fs2b4 fc0 sc0 ls196">49</div><div class="t m2b5 x45 h2b7 y2b6 ff1 fs2b5 fc0 sc0 ls186 wsf7">ET<span class="blank _4"></span>AP<span class="blank _2"></span>A</div><div class="t m2b6 x10f h2b8 y2b7 ff1 fs2b6 fc0 sc0 ls187 wsf8">EX<span class="blank _0"></span>CREÇÃ<span class="blank _1"></span>O</div><div class="t m2b7 xfe h2b9 y2b8 ff1 fs2b7 fc0 sc0 ls197">CLEARENCE</div><div class="t m2b8 x19 h2ba y2b9 ff1 fs2b8 fc0 sc0 ls17">(</div><div class="t m2b9 x110 h2bb y2ba ff1 fs2b9 fc0 sc0 ls198">CL</div><div class="t m2ba xe5 h2bc y2bb ff1 fs2ba fc0 sc0 ls17">)</div><div class="t m2bb x87 h2bd y2bc ff2 fs2bb fc0 sc0 ls199">OU</div><div class="t m2bc x5d h2be y2bd ff1 fs2bc fc0 sc0 ls188 wsf9">DEPURA<span class="blank _3"></span>ÇÃO</div><div class="t m2bd xb h2bf y2be ff1 fs2bd fc0 sc0 ls189 wsfa">Quantidade</div><div class="t m2be x20 h2c0 y2bf ff2 fs2be fc0 sc0 ls19a">de</div><div class="t m2bf xf0 h2c1 y2c0 ff1 fs2bf fc0 sc0 ls18a wsfb">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m2c0 x33 h2c2 y2c1 ff1 fs2c0 fc0 sc0 ls18b wsfc">depurada</div><div class="t m2c1 xb9 h2c3 y2c2 ff2 fs2c1 fc0 sc0 ls19b">do</div><div class="t m2c2 x2d h2c4 y2c3 ff1 fs2c2 fc0 sc0 ls18c wsfd">or<span class="blank _3"></span>ganismo</div><div class="t m2c3 xf9 h2c5 y2c4 ff2 fs2c3 fc0 sc0 ls19c wsfe">por</div><div class="t m2c4 x111 h2c6 y2c5 ff2 fs2c4 fc0 sc0 ls19d wsff">unidade</div><div class="t m2c5 xb9 h2c7 y2c6 ff2 fs2c5 fc0 sc0 ls19e">de</div><div class="t m2c6 xae h2c8 y2c7 ff2 fs2c6 fc0 sc0 ls19f ws100">tempo</div><div class="t m2c7 xc5 h2c9 y2c8 ff2 fs2c7 fc0 sc0 ls17">.</div><div class="t m2c8 x111 h2ca y2c9 ff1 fs2c8 fc0 sc0 ls18d ws101">FIL<span class="blank _9"></span>TRA<span class="blank _1"></span>ÇÃ<span class="blank _3"></span>O</div><div class="t m2c9 xf0 h2cb y2ca ff1 fs2c9 fc0 sc0 ls18e ws102">GL<span class="blank _1"></span>OMERULAR</div><div class="t m2ca x98 h2cc y2cb ff1 fs2ca fc0 sc0 ls18f ws103">SECREÇÃ<span class="blank _3"></span>O</div><div class="t m2cb x5f h2cd y2cc ff3 fs2cb fc0 sc0 ls17">→</div><div class="t m2cc x5b h2ce y2cd ff2 fs2cc fc0 sc0 ls17">o</div><div class="t m2cd x112 h2cf y2ce ff2 fs2cd fc0 sc0 ls1a0">que</div><div class="t m2ce xe7 h2d0 y2cf ff2 fs2ce fc0 sc0 ls1a1 ws104">não</div><div class="t m2cf xed h2d1 y2d0 ff2 fs2cf fc0 sc0 ls1a2 ws105">foi</div><div class="t m2d0 x70 h2d2 y2d1 ff1 fs2d0 fc0 sc0 ls190 ws106">filtrado</div><div class="t m2d1 x68 h2d3 y2d2 ff2 fs2d1 fc0 sc0 ls1a3 ws107">anteriormente</div><div class="t m2d2 x113 h2d4 y2d3 ff2 fs2d2 fc0 sc0 ls17">;</div><div class="t m2d3 x1d h2d5 y2d4 ff2 fs2d3 fc0 sc0 ls17">-</div><div class="t m2d4 x30 h2d6 y2d5 ff2 fs2d4 fc0 sc0 ls1a4">pH</div><div class="t m2d5 x15 h2d7 y2d6 ff2 fs2d5 fc0 sc0 ls17">e</div><div class="t m2d6 x10d h2d8 y2d7 ff2 fs2d6 fc0 sc0 ls1a5 ws108">tipos</div><div class="t m2d7 x78 h2d9 y2d8 ff2 fs2d7 fc0 sc0 ls1a6 ws109">solubilidade</div><div class="t m2d8 xd6 h2da y2d9 ff2 fs2d8 fc0 sc0 ls1a7 ws10a">não</div><div class="t m2d9 xd3 h2db y2da ff2 fs2d9 fc0 sc0 ls1a8 ws10b">influenciam</div><div class="t m2da x96 h2dc y2db ff2 fs2da fc0 sc0 ls17">a</div><div class="t m2db x98 h2dd y2dc ff1 fs2db fc0 sc0 ls1a9">TUBULAR</div><div class="t m2dc x12 h2de y2dd ff3 fs2dc fc0 sc0 ls17">→</div><div class="t m2dd x13 h2df y2de ff2 fs2dd fc0 sc0 ls1aa">Baixa</div><div class="t m2de x91 h2e0 y2df ff2 fs2de fc0 sc0 ls1ab ws10c">especificidade</div><div class="t m2df x1d h2e1 y2e0 ff2 fs2df fc0 sc0 ls1ac ws10d">passagem</div><div class="t m2e0 x1d h2e2 y2e1 ff2 fs2e0 fc0 sc0 ls17">-</div><div class="t m2e1 x5c h2e3 y2e2 ff2 fs2e1 fc0 sc0 ls1ad ws10e">Pa ss a g e m</div><div class="t m2e2 xf8 h2e4 y2e3 ff2 fs2e2 fc0 sc0 ls1ae">do</div><div class="t m2e3 x103 h2e5 y2e4 ff2 fs2e3 fc0 sc0 ls1af ws10f">fár m a c o</div><div class="t m2e4 xac h2e6 y2e5 ff2 fs2e4 fc0 sc0 ls1b0 ws110">livre</div><div class="t m2e5 x58 h2e7 y2e6 ff1 fs2e5 fc0 sc0 ls191 ws111">PRO<span class="blank _1"></span>XIMAL</div><div class="t m2e6 xcb h2e8 y2e7 ff3 fs2e6 fc0 sc0 ls17">→</div><div class="t m2e7 x114 h2e9 y2e8 ff2 fs2e7 fc0 sc0 ls1b1 ws112">Pod e</div><div class="t m2e8 x115 h2ea y2e9 ff2 fs2e8 fc0 sc0 ls192 ws113">ocorrer</div><div class="t m2e9 xf4 h2eb y2ea ff2 fs2e9 fc0 sc0 ls1b2 ws114">competição</div><div class="t m2ea x69 h2ec y2eb ff2 fs2ea fc0 sc0 ls1b3 ws115">por</div><div class="t m2eb x5b h2ed y2ec ff1 fs2eb fc0 sc0 ls1b4 ws116">transportador<span class="blank _3"></span>es</div><div class="t m2ec x116 h2ee y2ed ff2 fs2ec fc0 sc0 ls17">.</div><div class="t m2ed xc0 h2ef y2ee ff1 fs2ed fc0 sc0 ls193 ws117">REABSORÇÃ<span class="blank _1"></span>O</div><div class="t m2ee x49 h2f0 y2ef ff3 fs2ee fc0 sc0 ls17">→</div><div class="t m2ef xa2 h2f1 y2f0 ff2 fs2ef fc0 sc0 ls1b5 ws118">Rea b s o rç ã o</div><div class="t m2f0 xa7 h2f2 y2f1 ff2 fs2f0 fc0 sc0 ls1b6 ws119">passiv<span class="blank _3"></span>a</div><div class="t m2f1 x7d h2f3 y2f2 ff2 fs2f1 fc0 sc0 ls1b7">de</div><div class="t m2f2 xc0 h2f4 y2f3 ff1 fs2f2 fc0 sc0 ls1b8">TUBULAR</div><div class="t m2f3 x41 h2f5 y2f4 ff1 fs2f3 fc0 sc0 ls194 ws11a">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m2f4 x9d h2f6 y2f5 ff2 fs2f4 fc0 sc0 ls1b9 ws11b">não</div><div class="t m2f5 x117 h2f7 y2f6 ff2 fs2f5 fc0 sc0 ls17">-</div><div class="t m2f6 xa6 h2f8 y2f7 ff2 fs2f6 fc0 sc0 ls1ba">ionizado</div><div class="t m2f7 x5a h2f9 y2f8 ff2 fs2f7 fc0 sc0 ls1bb ws11c">llipossdúv<span class="blank _3"></span>el</div><div class="t m2f8 x114 h2fa y2f9 ff2 fs2f8 fc0 sc0 ls17">)</div><div class="t m2f9 xbf h2fb y2fa ff2 fs2f9 fc0 sc0 ls17">*</div><div class="t m2fa x10c h2fc y2fb ff2 fs2fa fc0 sc0 ls1bc">pH</div><div class="t m2fb x81 h2fd y2fc ff2 fs2fb fc0 sc0 ls1bd">da</div><div class="t m2fc x3c h2fe y2fd ff2 fs2fc fc0 sc0 ls1be ws11d">urina</div><div class="t m2fd x43 h2ff y2fe ff2 fs2fd fc0 sc0 ls1bf ws11e">pode</div><div class="t m2fe x37 h300 y2ff ff2 fs2fe fc0 sc0 ls1c0 ws11f">evit<span class="blank _5"> </span>ar</div><div class="t m2ff x118 h301 y300 ff2 fs2ff fc0 sc0 ls1c1 ws120">rea b s o rç ã o</div><div class="t m300 x10a h302 y301 ff1 fs300 fc0 sc0 ls195 ws121">DÍST<span class="blank _4"></span>AL</div><div class="t m301 x18 h303 y302 ff2 fs301 fc0 sc0 ls1c2">Ex</div><div class="t m302 xbf h304 y303 ff2 fs302 fc0 sc0 ls17">:</div><div class="t m303 xda h305 y304 ff2 fs303 fc0 sc0 ls1c3 ws122">fe n o b a r b i t a l</div><div class="t m304 xc9 h306 y305 ff2 fs304 fc0 sc0 ls17">(</div><div class="t m305 xa3 h307 y306 ff2 fs305 fc0 sc0 ls1c4 ws123">ácido</div><div class="t m306 x37 h308 y307 ff2 fs306 fc0 sc0 ls1c5">fraco</div><div class="t m307 x7b h309 y308 ff2 fs307 fc0 sc0 ls17">)</div><div class="t m308 xa7 h30a y309 ff2 fs308 fc0 sc0 ls17">t</div><div class="t m309 x27 h30b y30a ff2 fs309 fc0 sc0 ls1c6 ws124">bicarbonato</div><div class="t m30a x119 h30c y30b ff2 fs30a fc0 sc0 ls1c7 ws125">ldkaliniza</div><div class="t m30b xac h30d y30c ff2 fs30b fc0 sc0 ls17">a</div><div class="t m30c x18 h30e y30d ff2 fs30c fc0 sc0 ls1c8 ws126">urina</div><div class="t m30d x10c h30f y30e ff2 fs30d fc0 sc0 ls17">)</div><div class="t m30e x11a h310 y30f ff2 fs30e fc0 sc0 ls17">=</div><div class="t m30f x3f h311 y310 ff2 fs30f fc0 sc0 ls1c9 ws127">IONIZOU</div><div class="t m310 x11b h312 y311 ff2 fs310 fc0 sc0 ls17">!</div><div class="t m311 x46 h313 y312 ff2 fs311 fc0 sc0 ls17">(</div><div class="t m312 x55 h314 y313 ff2 fs312 fc0 sc0 ls1ca ws128">torn ou</div><div class="t m313 xc2 h315 y314 ff2 fs313 fc0 sc0 ls17">-</div><div class="t m314 xa6 h316 y315 ff2 fs314 fc0 sc0 ls1cb">se</div><div class="t m315 xd1 h317 y316 ff2 fs315 fc0 sc0 ls17">t</div><div class="t m316 x27 h318 y317 ff2 fs316 fc0 sc0 ls1cc ws129">hidrofílica</div><div class="t m317 xa0 h319 y318 ff2 fs317 fc0 sc0 ls17">=</div><div class="t m318 x5e h31a y319 ff2 fs318 fc0 sc0 ls1cd ws12a">será</div><div class="t m319 x6a h31b y31a ff2 fs319 fc0 sc0 ls1ce ws12b">excre t a d o</div><div class="t m31a xac h31c y31b ff2 fs31a fc0 sc0 ls1cf">na</div><div class="t m31b x32 h31d y31c ff2 fs31b fc0 sc0 ls1d0 ws12c">urina</div><div class="t m31c xd4 h31e y31d ff2 fs31c fc0 sc0 ls17">)</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg6.png" alt="Pré-visualização de imagem de arquivo"><div class="t m31d x11c h31f y31e ff1 fs31d fc0 sc0 ls17 ws12d">nr f<span class="blank _0"></span>armacodinãmican</div><div class="t m31e x3 h320 y31f ff1 fs31e fc0 sc0 ls1d1 ws12e">RECEPT<span class="blank _2"></span>ORES</div><div class="t m31f x5c h321 y320 ff1 fs31f fc0 sc0 ls1d2 ws12f">Inativo</div><div class="t m320 x11d h322 y321 ff4 fs320 fc0 sc0 ls17">④</div><div class="t m321 x11e h323 y322 ff1 fs321 fc0 sc0 ls17">~</div><div class="t m322 xb1 h324 y323 ff1 fs322 fc0 sc0 ls1d3 ws130">f<span class="blank _1"></span>ármaco<span class="blank _1"></span></div><div class="t m323 x30 h325 y324 ff1 fs323 fc0 sc0 ls1e7 ws131">At i vo</div><div class="t m324 xcf h326 y325 ff1 fs324 fc0 sc0 ls1e8">RAD</div><div class="t m325 x7d h327 y326 ff3 fs325 fc0 sc0 ls17">→</div><div class="t m326 x5e h328 y327 ff1 fs326 fc0 sc0 ls1e9 ws132">re c e p to r</div><div class="t m327 x5e h329 y328 ff2 fs327 fc0 sc0 ls1ea">Nem</div><div class="t m328 x11f h32a y329 ff2 fs328 fc0 sc0 ls1eb ws133">todos</div><div class="t m329 x92 h32b y32a ff2 fs329 fc0 sc0 ls1ec">os</div><div class="t m32a x4e h32c y32b ff1 fs32a fc0 sc0 ls1d4 ws134">f<span class="blank _3"></span>ármacos<span class="blank _3"></span></div><div class="t m32b xa9 h32d y32c ff2 fs32b fc0 sc0 ls1ed ws135">exerce m</div><div class="t m32c x72 h32e y32d ff2 fs32c fc0 sc0 ls1ee ws136">seus</div><div class="t m32d x2f h32f y32e ff1 fs32d fc0 sc0 ls1d5 ws137">ef<span class="blank _3"></span>eitos</div><div class="t m32e x52 h330 y32f ff2 fs32e fc0 sc0 ls1ef ws138">interagindo</div><div class="t m32f x93 h331 y330 ff2 fs32f fc0 sc0 ls17">4</div><div class="t m330 x120 h332 y331 ff2 fs330 fc0 sc0 ls1f0 ws139">rec e p t o re s</div><div class="t m331 x85 h333 y332 ff2 fs331 fc0 sc0 ls1f1">Ex</div><div class="t m332 x12 h334 y333 ff2 fs332 fc0 sc0 ls17">:</div><div class="t m333 x5f h335 y334 ff2 fs333 fc0 sc0 ls1f2 ws13a">antiácidos</div><div class="t m334 x121 h336 y335 ff2 fs334 fc0 sc0 ls17">.</div><div class="t m335 xc8 h337 y336 ff1 fs335 fc0 sc0 ls1d6 ws13b">F<span class="blank _4"></span>ÁRMA<span class="blank _1"></span>COS<span class="blank _4"></span></div><div class="t m336 xd4 h338 y337 ff3 fs336 fc0 sc0 ls17">→</div><div class="t m337 xfa h339 y338 ff2 fs337 fc0 sc0 ls1f3 ws13c">ativam</div><div class="t m338 x9d h33a y339 ff2 fs338 fc0 sc0 ls17">.</div><div class="t m339 xfc h33b y33a ff1 fs339 fc0 sc0 ls17">A</div><div class="t m33a xbd h33c y33b ff1 fs33a fc0 sc0 ls1f4 ws13d">GONÍST<span class="blank _6"></span>A</div><div class="t m33b xd0 h33d y33c ff1 fs33b fc0 sc0 ls17">S</div><div class="t m33c x48 h33e y33d ff2 fs33c fc0 sc0 ls1f5 ws13e">rec e p to r</div><div class="t m33d xb h33f y33e ff1 fs33d fc0 sc0 ls1f6 ws13f">AG O N I S T<span class="blank _4"></span>A S</div><div class="t m33e x95 h340 y33f ff1 fs33e fc0 sc0 ls17">A</div><div class="t m33f x11a h341 y340 ff1 fs33f fc0 sc0 ls1f7 ws140">AG O N I S T<span class="blank _4"></span>A S</div><div class="t m340 x4e h342 y341 ff1 fs340 fc0 sc0 ls1f8 ws141">AG O N Í S T<span class="blank _0"></span>A S</div><div class="t m341 xb h343 y342 ff1 fs341 fc0 sc0 ls1f9 ws142">To t a i s</div><div class="t m342 x35 h344 y343 ff1 fs342 fc0 sc0 ls1d7 ws143">P<span class="blank _1"></span>ar<span class="blank _3"></span>ciais<span class="blank _1"></span></div><div class="t m343 x122 h345 y344 ff1 fs343 fc0 sc0 ls17">A</div><div class="t m344 x5a h346 y345 ff1 fs344 fc0 sc0 ls1d8 ws144">INVERSOS</div><div class="t m345 x123 h347 y346 ff1 fs345 fc0 sc0 ls17">§</div><div class="t m346 x6 h348 y347 ff2 fs346 fc0 sc0 ls17">-</div><div class="t m347 x30 h349 y348 ff1 fs347 fc0 sc0 ls1d9 ws145">Resposta</div><div class="t m348 x74 h34a y349 ff1 fs348 fc0 sc0 ls1fa">biológica</div><div class="t m349 xcf h34b y34a ff2 fs349 fc0 sc0 ls1fb ws146">MÁXIMA</div><div class="t m34a x124 h34c y34b ff2 fs34a fc0 sc0 ls17">-</div><div class="t m34b xf1 h34d y34c ff2 fs34b fc0 sc0 ls1fc">Não</div><div class="t m34c x3e h34e y34d ff2 fs34c fc0 sc0 ls1fd ws147">produz</div><div class="t m34d x37 h34f y34e ff2 fs34d fc0 sc0 ls1fe ws148">res p o s t a</div><div class="t m34e x125 h350 y34f ff2 fs34e fc0 sc0 ls17">-</div><div class="t m34f x29 h351 y350 ff2 fs34f fc0 sc0 ls1ff ws149">Inativa</div><div class="t m350 xa1 h352 y351 ff2 fs350 fc0 sc0 ls17">o</div><div class="t m351 x126 h353 y352 ff2 fs351 fc0 sc0 ls200 ws14a">rec e p to r</div><div class="t m352 x1d h354 y353 ff2 fs352 fc0 sc0 ls17">-</div><div class="t m353 x127 h355 y354 ff2 fs353 fc0 sc0 ls201 ws14b">Estabiliza</div><div class="t m354 xad h356 y355 ff2 fs354 fc0 sc0 ls17">o</div><div class="t m355 xd2 h357 y356 ff1 fs355 fc0 sc0 ls202 ws14c">re c e p to r</div><div class="t m356 xf9 h358 y357 ff2 fs356 fc0 sc0 ls203">na</div><div class="t m357 x110 h359 y358 ff2 fs357 fc0 sc0 ls204 ws14d">tão</div><div class="t m358 x128 h35a y359 ff1 fs358 fc0 sc0 ls205 ws14e">grande</div><div class="t m359 xb4 h35b y35a ff1 fs359 fc0 sc0 ls1da ws14f">quanto</div><div class="t m35a x7b h35c y35b ff2 fs35a fc0 sc0 ls17">o</div><div class="t m35b x125 h35d y35c ff2 fs35b fc0 sc0 ls17">-</div><div class="t m35c x62 h35e y35d ff2 fs35c fc0 sc0 ls206">Há</div><div class="t m35d x51 h35f y35e ff2 fs35d fc0 sc0 ls207 ws150">então</div><div class="t m35e xa9 h360 y35f ff2 fs35e fc0 sc0 ls208">menos</div><div class="t m35f x113 h361 y360 ff2 fs35f fc0 sc0 ls209 ws151">rec e p t o re s</div><div class="t m360 x1d h362 y361 ff2 fs360 fc0 sc0 ls20a ws152">for<span class="blank _5"> </span>m a</div><div class="t m361 x24 h363 y362 ff2 fs361 fc0 sc0 ls20b ws153">ativa</div><div class="t m362 x34 h364 y363 ff2 fs362 fc0 sc0 ls20c ws154">Ag o n i s t a</div><div class="t m363 x129 h365 y364 ff2 fs363 fc0 sc0 ls20d ws155">To t a l</div><div class="t m364 x7a h366 y365 ff2 fs364 fc0 sc0 ls17">,</div><div class="t m365 x46 h367 y366 ff2 fs365 fc0 sc0 ls20e">mesmo</div><div class="t m366 x5a h368 y367 ff2 fs366 fc0 sc0 ls20f ws156">ativados</div><div class="t m367 x12a h369 y368 ff2 fs367 fc0 sc0 ls210">do</div><div class="t m368 x12b h36a y369 ff2 fs368 fc0 sc0 ls211">que</div><div class="t m369 x8b h36b y36a ff2 fs369 fc0 sc0 ls212">na</div><div class="t m36a x6c h36c y36b ff2 fs36a fc0 sc0 ls213 ws157">ausência</div><div class="t m36b x80 h36d y36c ff2 fs36b fc0 sc0 ls214 ws158">ocupando</div><div class="t m36c x97 h36e y36d ff2 fs36c fc0 sc0 ls215 ws159">todos</div><div class="t m36d x10 h36f y36e ff2 fs36d fc0 sc0 ls216">08</div><div class="t m36e x8a h370 y36f ff2 fs36e fc0 sc0 ls217">do</div><div class="t m36f x1c h371 y370 ff1 fs36f fc0 sc0 ls1db ws15a">f<span class="blank _3"></span>ármaco</div><div class="t m370 x64 h372 y371 ff2 fs370 fc0 sc0 ls17">.</div><div class="t m371 x79 h373 y372 ff2 fs371 fc0 sc0 ls218 ws15b">rec e p to re s</div><div class="t m372 x67 h374 y373 ff2 fs372 fc0 sc0 ls17">.</div><div class="t m373 x43 h375 y374 ff1 fs373 fc0 sc0 ls17">f</div><div class="t m374 x110 h376 y375 ff1 fs374 fc0 sc0 ls219 ws15c">Po d e</div><div class="t m375 xd7 h377 y376 ff2 fs375 fc0 sc0 ls21a ws15d">atuar</div><div class="t m376 x46 h378 y377 ff2 fs376 fc0 sc0 ls21b ws15e">como</div><div class="t m377 x10f h379 y378 ff1 fs377 fc0 sc0 ls1dc ws15f">antagonist<span class="blank _3"></span>a</div><div class="t m378 x8 h37a y379 ff2 fs378 fc0 sc0 ls21c">do</div><div class="t m379 x12c h37b y37a ff1 fs379 fc0 sc0 ls1dd ws160">agonista</div><div class="t m37a xd0 h37c y37b ff1 fs37a fc0 sc0 ls21d ws161">tota l</div><div class="t m37b xd4 h37d y37c ff2 fs37b fc0 sc0 ls17">.</div><div class="t m37c x23 h37e y37d ff1 fs37c fc0 sc0 ls1de ws162">F<span class="blank _4"></span>ÁRMA<span class="blank _1"></span>COS<span class="blank _2"></span></div><div class="t m37d x32 h37f y37e ff3 fs37d fc0 sc0 ls17">→</div><div class="t m37e x124 h380 y37f ff2 fs37e fc0 sc0 ls21e ws163">Não</div><div class="t m37f x3c h381 y380 ff2 fs37f fc0 sc0 ls21f ws164">deixam</div><div class="t m380 x82 h382 y381 ff2 fs380 fc0 sc0 ls220">com</div><div class="t m381 x12d h383 y382 ff1 fs381 fc0 sc0 ls1df ws165">que</div><div class="t m382 x7c h384 y383 ff1 fs382 fc0 sc0 ls1e0 ws166">agonista</div><div class="t m383 xd8 h385 y384 ff1 fs383 fc0 sc0 ls1e1 ws167">ANT<span class="blank _0"></span>A<span class="blank _3"></span>GONIST<span class="blank _4"></span>AS</div><div class="t m384 xdb h386 y385 ff2 fs384 fc0 sc0 ls221 ws168">liguem</div><div class="t m385 x8 h387 y386 ff2 fs385 fc0 sc0 ls17">-</div><div class="t m386 xa3 h388 y387 ff2 fs386 fc0 sc0 ls222">se</div><div class="t m387 xb7 h389 y388 ff2 fs387 fc0 sc0 ls223">aos</div><div class="t m388 xb5 h38a y389 ff2 fs388 fc0 sc0 ls224 ws169">rec e p to re s</div><div class="t m389 x1e h38b y38a ff1 fs389 fc0 sc0 ls225">COMPETITIVOS</div><div class="t m38a x12d h38c y38b ff1 fs38a fc0 sc0 ls1e2 ws16a">IRREVERSÍVEIS</div><div class="t m38b x1e h38d y38c ff2 fs38b fc0 sc0 ls226 ws16b">Quando</div><div class="t m38c x21 h38e y38d ff1 fs38c fc0 sc0 ls1e3 ws16c">Antagonist<span class="blank _3"></span>as</div><div class="t m38d x18 h38f y38e ff1 fs38d fc0 sc0 ls227">ligam</div><div class="t m38e x3b h390 y38f ff2 fs38e fc0 sc0 ls17">-</div><div class="t m38f x124 h391 y390 ff2 fs38f fc0 sc0 ls228">se</div><div class="t m390 xf1 h392 y391 ff2 fs390 fc0 sc0 ls229">de</div><div class="t m391 x9 h393 y392 ff1 fs391 fc0 sc0 ls22a">Liga</div><div class="t m392 x9e h394 y393 ff2 fs392 fc0 sc0 ls17">-</div><div class="t m393 x118 h395 y394 ff2 fs393 fc0 sc0 ls22b">se</div><div class="t m394 xe6 h396 y395 ff8 fs394 fc0 sc0 ls22c ws16d">fo r<span class="blank _5"> </span>t e m e n te</div><div class="t m395 x5e h397 y396 ff2 fs395 fc0 sc0 ls22d">do</div><div class="t m396 x9c h398 y397 ff2 fs396 fc0 sc0 ls22e">local</div><div class="t m397 x64 h399 y398 ff2 fs397 fc0 sc0 ls22f ws16e">ativo</div><div class="t m398 x92 h39a y399 ff2 fs398 fc0 sc0 ls230">da</div><div class="t m399 x1e h39b y39a ff2 fs399 fc0 sc0 ls231 ws16f">for<span class="blank _5"> </span>m a</div><div class="t m39a x4 h39c y39b ff2 fs39a fc0 sc0 ls232 ws170">revers í vel</div><div class="t m39b x104 h39d y39c ff2 fs39b fc0 sc0 ls17">.</div><div class="t m39c xbb h39e y39d ff1 fs39c fc0 sc0 ls1e4 ws171">Inibição</div><div class="t m39d x19 h39f y39e ff2 fs39d fc0 sc0 ls233 ws172">pode</div><div class="t m39e xc1 h3a0 y39f ff2 fs39e fc0 sc0 ls234">ser</div><div class="t m39f x9 h3a1 y3a0 ff2 fs39f fc0 sc0 ls235 ws173">rec e p to r</div><div class="t m3a0 x2e h3a2 y3a1 ff2 fs3a0 fc0 sc0 ls17">.</div><div class="t m3a1 xb1 h3a3 y3a2 ff2 fs3a1 fc0 sc0 ls236">Não</div><div class="t m3a2 x4f h3a4 y3a3 ff2 fs3a2 fc0 sc0 ls237 ws174">consegue</div><div class="t m3a3 x52 h3a5 y3a4 ff2 fs3a3 fc0 sc0 ls238">ser</div><div class="t m3a4 x12e h3a6 y3a5 ff2 fs3a4 fc0 sc0 ls239 ws175">superado</div><div class="t m3a5 x44 h3a7 y3a6 ff2 fs3a5 fc0 sc0 ls23a ws176">superada</div><div class="t m3a6 x78 h3a8 y3a7 ff2 fs3a6 fc0 sc0 ls23b ws177">aumentando</div><div class="t m3a7 x39 h3a9 y3a8 ff2 fs3a7 fc0 sc0 ls17">a</div><div class="t m3a8 x18 h3aa y3a9 ff2 fs3a8 fc0 sc0 ls23c ws178">concentração</div><div class="t m3a9 x11e h3ab y3aa ff2 fs3a9 fc0 sc0 ls23d ws179">por</div><div class="t m3aa x118 h3ac y3ab ff2 fs3aa fc0 sc0 ls23e">mais</div><div class="t m3ab x7d h3ad y3ac ff1 fs3ab fc0 sc0 ls1e5 ws17a">agonista</div><div class="t m3ac x12 h3ae y3ad ff2 fs3ac fc0 sc0 ls17">.</div><div class="t m3ad x1e h3af y3ae ff2 fs3ad fc0 sc0 ls23f">do</div><div class="t m3ae x24 h3b0 y3af ff1 fs3ae fc0 sc0 ls1e6 ws17b">agonista</div><div class="t m3af xd2 h3b1 y3b0 ff2 fs3af fc0 sc0 ls17">.</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/278e6ca0-024c-4691-a7b2-0b90fbf82af4/bg7.png" alt="Pré-visualização de imagem de arquivo"><div class="t m3b0 x44 h3b2 y3b1 ff1 fs3b0 fc0 sc0 ls247 ws17c">PO<span class="blank _a"></span>TÊNCIA</div><div class="t m3b1 x98 h3b3 y3b2 ff1 fs3b1 fc0 sc0 ls240 ws17d">EFICÁ<span class="blank _1"></span>CIA</div><div class="t m3b2 xfc h3b4 y3b3 ff1 fs3b2 fc0 sc0 ls248 ws17e">Quanto</div><div class="t m3b3 x107 h3b5 y3b4 ff2 fs3b3 fc0 sc0 ls249">menos</div><div class="t m3b4 xaf h3b6 y3b5 ff1 fs3b4 fc0 sc0 ls241 ws17f">f<span class="blank _3"></span>ármaco<span class="blank _3"></span></div><div class="t m3b5 xf h3b7 y3b6 ff2 fs3b5 fc0 sc0 ls24a ws180">for</div><div class="t m3b6 x12f h3b8 y3b7 ff2 fs3b6 fc0 sc0 ls24b ws181">necessário</div><div class="t m3b7 x11b h3b9 y3b8 ff2 fs3b7 fc0 sc0 ls24c ws182">Ta m a n h o</div><div class="t m3b8 x118 h3ba y3b9 ff2 fs3b8 fc0 sc0 ls24d">da</div><div class="t m3b9 x88 h3bb y3ba ff2 fs3b9 fc0 sc0 ls24e ws183">res p o s t a</div><div class="t m3ba x130 h3bc y3bb ff2 fs3ba fc0 sc0 ls24f ws184">quando</div><div class="t m3bb x6 h3bd y3bc ff2 fs3bb fc0 sc0 ls250 ws185">para</div><div class="t m3bc xbd h3be y3bd ff1 fs3bc fc0 sc0 ls251 ws186">pr<span class="blank _3"></span>oduzir</div><div class="t m3bd x21 h3bf y3be ff2 fs3bd fc0 sc0 ls252 ws187">efeit<span class="blank _3"></span>o</div><div class="t m3be xcd h3c0 y3bf ff2 fs3be fc0 sc0 ls17">,</div><div class="t m3bf x7 h3c1 y3c0 ff2 fs3bf fc0 sc0 ls253">mais</div><div class="t m3c0 xac h3c2 y3c1 ff2 fs3c0 fc0 sc0 ls254 ws188">potente</div><div class="t m3c1 x110 h3c3 y3c2 ff2 fs3c1 fc0 sc0 ls255">ele</div><div class="t m3c2 xc1 h3c4 y3c3 ff2 fs3c2 fc0 sc0 ls17">é</div><div class="t m3c3 xe5 h3c5 y3c4 ff2 fs3c3 fc0 sc0 ls17">.</div><div class="t m3c4 xb4 h3c6 y3c5 ff2 fs3c4 fc0 sc0 ls256 ws189">interage</div><div class="t m3c5 xc6 h3c7 y3c6 ff2 fs3c5 fc0 sc0 ls257">com</div><div class="t m3c6 x84 h3c8 y3c7 ff2 fs3c6 fc0 sc0 ls17">o</div><div class="t m3c7 xb1 h3c9 y3c8 ff2 fs3c7 fc0 sc0 ls258 ws18a">rec e p to r</div><div class="t m3c8 x27 h3ca y3c9 ff1 fs3c8 fc0 sc0 ls17">1</div><div class="t m3c9 x99 h3cb y3ca ff1 fs3c9 fc0 sc0 ls242 ws18b">Eficácia</div><div class="t m3ca x84 h3cc y3cb ff2 fs3ca fc0 sc0 ls259">máxima</div><div class="t m3cb x62 h3cd y3cc ff2 fs3cb fc0 sc0 ls17">:</div><div class="t m3cc x12c h3ce y3cd ff1 fs3cc fc0 sc0 ls25a ws18c">quando</div><div class="t m3cd x131 h3cf y3ce ff2 fs3cd fc0 sc0 ls25b ws18d">todos</div><div class="t m3ce x76 h3d0 y3cf ff2 fs3ce fc0 sc0 ls25c">os</div><div class="t m3cf x62 h3d1 y3d0 ff2 fs3cf fc0 sc0 ls25d ws18e">rec e p to re s</div><div class="t m3d0 xd8 h3d2 y3d1 ff1 fs3d0 fc0 sc0 ls243 ws18f">ÍNDICE</div><div class="t m3d1 x9d h3d3 y3d2 ff2 fs3d1 fc0 sc0 ls25e ws190">estão</div><div class="t m3d2 x57 h3d4 y3d3 ff2 fs3d2 fc0 sc0 ls25f ws191">ocupados</div><div class="t m3d3 x87 h3d5 y3d4 ff1 fs3d3 fc0 sc0 ls244 ws192">TERAPÊUTICO</div><div class="t m3d4 x6 h3d6 y3d5 ff2 fs3d4 fc0 sc0 ls260">d.</div><div class="t m3d5 x5c h3d7 y3d6 ff1 fs3d5 fc0 sc0 ls245 ws193">F<span class="blank _3"></span>ácil<span class="blank _3"></span></div><div class="t m3d6 xc h3d8 y3d7 ff2 fs3d6 fc0 sc0 ls261 ws194">toxicidad<span class="blank _5"> </span>e</div><div class="t m3d7 x1d h3d9 y3d8 ff2 fs3d7 fc0 sc0 ls17">^</div><div class="t m3d8 xaa h3da y3d9 ff1 fs3d8 fc0 sc0 ls246 ws195">Segur<span class="blank _3"></span>o</div><div class="t m3d9 x132 h3db y3da ff2 fs3d9 fc0 sc0 ls262">em</div><div class="t m3da x26 h3dc y3db ff2 fs3da fc0 sc0 ls263 ws196">doses</div><div class="t m3db x8c h3dd y3dc ff2 fs3db fc0 sc0 ls264 ws197">elev<span class="blank _3"></span>adas</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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