Agascalm™: Ativo natural para pele sensível e com rosácea

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Redness
Dehydration
Dull skin tone
Rosacea-prone skin
Reduces stress-induced skin inflammation and redness
agascalm™
is an active from the mexican plant 
Agastache mexicana used in Mexico 
to treat “frightful and shocking 
situations”. This project is a coopera-
tion between Provital Group and the 
University of Querétaro (México) to 
preserve biodiversity and develop-
ment of a community of women of this 
area, always in terms of fair trade. 
agascalm™
agascalmTM helps to overcome these problems by inhibiting: 
1. The release of some of the cytokines responsible for these disorders.
2. The movement of the transcription factor NF-kB to the nucleous, that 
boosts the inflammatory response.
 Reduces skin redness
 Improves vascular tonicity
 Restores the barrier function for a moisturized skin
 Enhances the skin radiance and evens skin tone.
Cytokines
+
Chemokines
+
iNOS...
Skin Inflammation
NF-kB
Skin 
KeratinocyteMind-Skin
Connection
The stressful 
situations we face 
nowadays in our 
daily life affect our 
complexion.
45 volunteers, 30 with psychological stress and 15 with Rosacea-prone skin, 
between 19 and 62 years old. Active formula (2% agascalm™) on one half of 
the face and placebo on the other. Two daily applications, 28 days.
In vitro efficacy
SENSITIVE SKIN
In vivo efficacy
70%
10%
13% 6%
Experiments on human keratinocytes
Inhibition NF-kB 
transcriber 
At 4 hours, AgascalmTM (0.30%) decreases the expression of seven of the 
fifteen selected genes to study, related to the inflammatory effects. 
AgascalmTM also recovers a youthful 
radiance and a uniform complexion. 
Fluorescence shows how, in stressed keratinocytes, NF-kB factor 
migrates to the nucleous. With AgascalmTM it returns to the citoplasm 
inhibiting the inflammatory response.
Cytokine synthesis 
inhibition
Vasodilatation 
reduction
Redness 
reduction
Lower skin 
temperature 
which means less 
stressed skin
Water loss 
reduction
Moisturizing 
effect
104%
30%
Stressed 
Stressed + AgascalmTM 0.30% 
- 0,4 Cº
D0 D28 
Redness reduction