Buscar

Imunidade Celular - Imunidade Adaptativa - Imunologia

Prévia do material em texto

,081,'$'(�&(/8/$5
4XDQGR�R�DQWÊJHQR�WHP�DFHVVR�DR�LQWHULRU�GDV�FÆOXODV��D�LPXQLGDGH�KXPRUDO��OLQIÐFLWRV�%��QÀR�
DWXD��TXHP�LU¾�DWXDU�VHUÀR�RV�OLQIÐFLWRV�7��TXH�VÀR�UHVSRQV¾YHLV�SHOD�LPXQLGDGH�FHOXODU���2V�
DQWLFRUSRV�QÀR�WÇP�DFHVVR�DRV�PLFURUJDQLVPRV�TXH�YLYHP�H�VH�PXOWLSOLFDP�GHQWUR�GH�FÆOXODV�
LQIHFWDGDV�
ͻ
��9ÊUXV�VÀR�DQWÊJHQRV�LQWUDFHOXODUHV�REULJDWÐULRV�
2V�OLQIÐFLWRV�7�WÇP�XPD�HVSHFLILFLGDGH�UHVWULWD�SDUD�DQWÊJHQRV��HOHV�UHFRQKHFHP�SHSWÊGHRV�
GHULYDGRV�GDV�SURWHÊQDV�HVWUDQKDV�TXH�HVWÀR�OLJDGDV�½V�SURWHÊQDV�GR�KRVSHGHLUR�GHQRPLQDGDV�
FRPSOH[R�SULQFLSDO�GH�KLVWRFRPSDWLELOLGDGH��0+&���DV�TXDLV�VÀR�H[SUHVVDV�QDV�VXSHUIÊFLHV�GH�
RXWUDV�FÆOXODV�
ͻ
� 2�0+&��DQWHV�GH�VHU�H[SRVWR��HOH�ILFD�QR�UHWÊFXOR�HQGRSODVP¾WLFR�GDV�FÆOXODV�
� 2V�OLQIÐFLWRV�7�PDWDP�DV�FÆOXODV�LQIHFWDGDV�SRU�FRPSOHWR��HOHV�QÀR�HOLPLQDP�DSHQDV�R�YÊUXV��8PD�
YH]�TXH�RV�OLQIÐFLWRV�7�LGHQWLILFDP�XPD�FÆOXODV�LQIHFWDGD��HOHV�LUÀR�PDWDU�D�FÆOXOD�LQIHFWDGD�
� 4XDQGR�XP�YÊUXV�SHQHWUD�D�FÆOXOD��HOH�PXGD�YLDV�PHWDEÐOLFDV��HVWUXWXUDV��GD�FÆOXOD��(VVDV�FÆOXODV�
LUÀR�VH�PXOWLSOLFDU��3RU�LVVR�TXH�RV�OLQIÐFLWRV�7�PDWDP�D�FÆOXOD�LQIHFWDGD�
2X�VHMD��DV�FÆOXODV�LQIHFWDGDV�WÇP�XP�PHFDQLVPR�TXH��DYLVDP��TXH�HVWÀR�LQIHFWDGDV��$V�FÆOXODV�
LQIHFWDGDV�H[SÒHP�XP�IUDJPHQWR�GD�FDSD�SURWHLFD�GR�YÊUXV��IUDJPHQWRV�SHSWÊGHRV�GH�SURWHÊQDV�
DQWLJÇQLFD���(VVHV�IUDJPHQWRV�SURWHLFRV�ILFDP�H[SRVWRV�OLJDGRV�DR�FRPSOHFR�0+&��FRPSOH[R�
PDLRU�GH�KLVWRFRPSDWLELOLGDGH���(QWÀR�D�FÆOXOD�H[SÒH�R�0+&��H�QR�0+&�HVW¾�SUHVHQWH�XP�
IUDJPHQWR�SURWHLFR�GR�DQWÊJHQR�SDUD�TXH�RV�OLQIÐFLWRV�7�UHFRQKHÄDP�
ͻ
� 7RGDV�DV�FÆOXODV�SRVVÊYHLV�GH�VHUHP�LQIHFWDGDV�SRVVXHP�0+&��7RGDV�DV�FÆOXODV�KXPDQDV�SRGHP�
VHU�LQIHFWDGDV�SRU�PLFURUJDQLVPR��DWÆ�DV�FÆOXODV�GR�VLVWHPD�LPXQH��&DGD�FÆOXOD�HVSHFÊILFD�GH��FDGD�
ÐUJÀR�WHP�VHX�SUÐSULR�0+&�
$R�DSUHVHQWDU�R�0+&��D�FÆOXOD�SDVVD�D�VHU�FKDPDGD�GH FÆOXOD�DSUHVHQWDGRUD�GH�DQWÊJHQR�
�$3&���1HP�WRGD�FÆOXOD�LQIHFWDGD�Æ�XPD�$3&��DSHQDV�TXDQGR�WLYHU�R�0+&�
ͻ
� 2�OLQIÐFLWR�7�VÐ�Æ�DWLYDGR�VH�HOH�VH�OLJDU�DR�0+&�GD�$3&��$�FÆOXOD�VHPSUH�LU¾�DSUHVHQWDU�R�0+&�
FRP�R�IUDJPHQWR�SURWHLFR�GR�DQWÊJHQR�
$�GHSHQGÇQFLD�GR�OLQIÐFLWR�7�DR�0+&�SDUD�VHU�DWLYDGR�Æ�FKDPDGR�GH�5HVWULÄÀR�SHOR�0+&�ͻ
([LVWH�QR�VLVWHPD�LPXQROÐJLFR�XP�WLSR�GH�$3&�TXH�D�IXQÄÀR�GHOD�Æ�DWLYDU�RV�OLQIÐFLWR�7��¦�VXD�
×QLFD�IXQÄÀR��(�Æ�FKDPDGD�GH�$3&�SURILVVLRQDO��RX�FÆOXOD�GHQGUÊWLFD�H�HVW¾�ORFDOL]DGD�QD�
HSLGHUPH��(VVD�FÆOXOD�IDJRFLWD�R�DQWÊJHQR�H�YDL�DWÆ�RV�OLQIRQRGRV��RQGH�HVWÀR�RV�OLQIÐFLWRV��H�
DSUHVHQWD�R�DQWÊJHQR�DRV�OLQIÐFLWRV�7��2�OLQIÐFLWR�7�VHU¾�DWLYDGR�H�LU¾�DWÆ�DV�FÆOXODV�TXH�SRVVXHP�
0+&��$�FÆOXOD�GHQGUÊWLFD�DX[LOLD�QD�DWLYDÄÀR�GH�OLQIÐFLWRV�
ͻ
� 6H�R�OLQIÐFLWR�7�TXH�IRL�DWLYR�SHOD�FÆOXOD�GHQGUÊWLFD�QÀR�HQFRQWUDU�R�0+&�GH�DOJXPD�FÆOXOD��VXD�
DWLYDÄÀR�YDL�GLPLQXLQGR��
,PXQLGDGH�&HOXODU�� ,PXQLGDGH�$GDSWDWLYD
ƋƵŝŶƚĂͲĨĞŝƌĂ͕�ϭ�ĚĞ�Ăďƌŝů�ĚĞ�ϮϬϮϭ Ϯϭ͗Ϯϯ
� (�SRVVÊYHO�TXH�XPD�FÆOXOD�LQIHFWDGD�QÀR�H[SRQKD�R�0+&�
([SRVLÄÀR�GR�0+&��R�IUDJPHQWR�SURWHLFR�HQWUD�QR�UHWÊFXOR�HQGRSODVP¾WLFR�SRU�XP�
WUDQVSRUWDGRU��FKDPDGR�GH�7UDQVSRUWDGRU�GH�DQWÊJHQR�SURWHLFR��7$3���H�VH�OLJD�DR�0+&��2�0+&�
VDL�GR�UHWÊFXOR�HQYROWR�SRU�XPD�PHPEUDQD��VDL�QXPD�YHVÊFXOD��H�HVVD�YHVÊFXOD�VH�IXQGH�FRP�D�
PHPEUDQD�SODVP¾WLFD�GD�FÆOXOD�H�H[SÒH�R�0+&�
ͻ
$OJXQV�YÊUXV�GHVHQYROYHUDP�D�FDSDFLGDGH�GH�EORTXHDU�R�7$3�QR�UHWÊFXOR�HQGRSODVP¾WLFR�H�
LPSHGLU�GD�FÆOXOD�H[SRU�R�0+&�
ͻ
/,1)°&,726�7&'��(�7&'�
� /LQIÐFLWRV�VH�GLIHUHQFLDP�GH�RXWUDV�FÆOXODV�SRU�SRVVXÊUHP�UHFHSWRUHV�
8PD�YH]�LQIHFWDGD��RV�OLQIÐFLWRV�7�LUÀR�PDWDU�D�FÆOXOD�GH�IRUPD�GLUHWD�RX�LQGLUHWD�ͻ
2V�/LQIÐFLWRV�7�&'� PDWDP�D�FÆOXOD�GH�IRUPD�GLUHWD��(VWÀR�PXLWR�SUHVHQWHV�QDV�LQIHFÄÒHV�SHOR�
FRURQDYÊUXV��(VVHV�OLQIÐFLWRV�VÀR�FKDPDGRV�GH�FLWRWÐ[LFRV�RX�FLWROÊWLFRV��(OHV�SRVVXHP�JU¿QXORV�
FLWRWÐ[LFRV�
ͻ
2V�JU¿QXORV�GRV�7�&'��VÀR��SHUIRULQD��IXQÄÀR�GH�SHUIXUDU�D�PHPEUDQD��H�JUDQ]LPDV��IXQÄÀR�GH�
DWLYDU�R�PHFDQLVPR�GH�DSRSWRVH���$�VHUJOLFLQD�VHUYH�GH�DQFRUDJHP�SDUD�WUDQVSRUWDU�RV�JU¿QXORV��
TXDQGR�OLEHUDGRV��DWÆ�D�PHPEUDQD�GD�FÆOXOD�LQIHFWDGD�
ͻ
2�OLQIÐFLWR�7�&'��VH�OLJD�DR�0+&��HQWÀR�Æ�DWLYDGR��$R�VHU�DWLYDGR��R�OLQIÐFLWR�OLEHUD�RV�JU¿QXORV�
DQFRUDGRV�QD�VHUJOLFLQD��HOD�WUDQVSRUWD�RV�JU¿QXORV���D�SHUIRULQD�SHUIXUD�D�PHPEUDQD�GD�FÆOXOD�H�
D�VHUJOLFLQD�OLEHUD�HQWÀR�RV�JU¿QXORV�GH�JUDQ]LPDV�SHQHWUD�D�FÆOXOD�LQIHFWDGD�H�DWLYD�R�
PHFDQLVPR�GH�DSRSWRVH��PRUWH�SURJUDPDGD��
ͻ
2V /LQIÐFLWRV�7�&'� QÀR�SRVVXHP�RV�JU¿QXORV�FLWRWÐ[LFRV��HOH�QÀR�PDWD�D�FÆOXOD�LQIHFWDGD�GH�
IRUPD�GLUHWD��4XDQGR�R�7�&'��VH�OLJD�D�XPD�FÆOXOD�LQIHFWDGD��WDPEÆP�SHOR�0+&���UHFRQKHFH�D�
FÆOXOD�LQIHFWDGD��H�OLEHUD�FLWRFLQDV��&LWRFLQDV�VÀR�PROÆFXODV�GH�HVWLPXODÄÀR�GH�XPD�UHVSRVWD�
LPXQROÐJLFD�
ͻ
2V�OLQIÐFLWRV�7�&'��VÀR�FKDPDGRV�GH�DX[LOLDUHV�RX�7+��+HOSHU��ͻ
$V�FLWRFLQDV�OLEHUDGDV�SHORV�7�&'��DWLYDP�FÆOXODV�IDJRFLW¾ULDV��TXH�LUÀR�IDJRFLWDU�D�FÆOXOD�
LQIHFWDGD��$V�FLWRFLQDV�WDPEÆP�DXPHQWDP�SURFHVVRV�LQIODPDWÐULRV��2V�OLQIÐFLWRV�7�&'��WDPEÆP�
OLEHUDP�DV�FLWRFLQDV�QD�FRUUHQWH�VDQJXÊQHD��HVWLPXODQGR�D�DWLYDÄÀR��SUROLIHUDÄÀR�H�GLIHUHQFLDÄÀR�
GH�RXWURV�OLQIÐFLWRV�%�H�7��&'��H�&'����2X�VHMD��HVVDV�FLWRFLQDV�WDPEÆP�DXPHQWDP�D�SURGXÄÀR�
GH�DQWLFRUSRV�
ͻ

Continue navegando