The evidence for neuroleptic efficacy for paranoid personality disorder is limited. One open clinical trial found that pimozide was helpful for some patients with various personality disorders, including paranoid personality disorder. Another study found that mesoridazine was helpful for some adolescents with certain forms of personality disorder, including paranoid personality disorder. However, it is important to note that these studies are limited in scope and more research is needed to establish the effectiveness of neuroleptics for paranoid personality disorder.
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