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What is the accepted model for the interaction between enzymes and substrates? I - The lock-and-key model, proposed by Emil Fisher, explains the r...

What is the accepted model for the interaction between enzymes and substrates?

I - The lock-and-key model, proposed by Emil Fisher, explains the recognition of the substrate by the enzyme.
II - In the lock-and-key model, the active site of the enzyme is pre-formed and has a shape complementary to the substrate molecule.
III - The lock-and-key model does not explain the interaction of enzymes with inhibitors and substrate analogs.
IV - The induced fit model, proposed by Daniel Kosland, explains that the contact with the substrate molecule induces conformational changes in the enzyme that optimize the interactions with the residues of the active site.
a) Only I and II are correct.
b) Only III and IV are correct.
c) Only II and IV are correct.
d) All statements are correct.

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Aula_4_
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Bioquímica I Universidade Estácio de SáUniversidade Estácio de Sá

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The accepted model for the interaction between enzymes and substrates is the induced fit model, proposed by Daniel Kosland, which explains that the contact with the substrate molecule induces conformational changes in the enzyme that optimize the interactions with the residues of the active site. Therefore, alternative c) Only II and IV are correct.

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