What is the mechanism of action of coumarin anticoagulants? I- Inhibition of the gamma-carboxylation of glutamate residues in coagulation factors....
What is the mechanism of action of coumarin anticoagulants?
I- Inhibition of the gamma-carboxylation of glutamate residues in coagulation factors.
II- Inhibition of the oxidation of vitamin K.
III- Inhibition of the reduction of vitamin K epoxide.
IV- Inhibition of the formation of thrombin.
a) I and II are correct.
b) II and IV are correct.
c) I and III are correct.
d) III and IV are correct.
I- Inhibition of the gamma-carboxylation of glutamate residues in coagulation factors.
II- Inhibition of the oxidation of vitamin K.
III- Inhibition of the reduction of vitamin K epoxide.
IV- Inhibition of the formation of thrombin.
a) I and II are correct.
b) II and IV are correct.
c) I and III are correct.
d) III and IV are correct.
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A alternativa correta é a letra A) I e II estão corretas. Os anticoagulantes cumarínicos, como a varfarina, agem inibindo a carboxilação gama de resíduos de glutamato nos fatores de coagulação dependentes de vitamina K (II, VII, IX e X), impedindo assim a formação de coágulos sanguíneos. Além disso, a varfarina inibe a oxidação da vitamina K, que é necessária para a carboxilação dos fatores de coagulação.
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