What is the main mechanism involved in drug interactions with warfarin? I - Pharmacokinetic mechanisms that involve mainly the induction of the P4...
What is the main mechanism involved in drug interactions with warfarin?
I - Pharmacokinetic mechanisms that involve mainly the induction of the P450 CYP2C9 enzyme, enzymatic inhibition, and reduction of binding to plasma proteins.
II - Pharmacodynamic mechanisms involved in drug interactions with warfarin include synergism, competitive antagonism, and alteration of the physiological control loop of vitamin K.
III - The most dangerous interactions with warfarin are those that increase the anticoagulant effect and the risk of bleeding.
a) Only I is correct.
b) Only II is correct.
c) Only III is correct.
d) I and II are correct.
e) I, II, and III are correct.
I - Pharmacokinetic mechanisms that involve mainly the induction of the P450 CYP2C9 enzyme, enzymatic inhibition, and reduction of binding to plasma proteins.
II - Pharmacodynamic mechanisms involved in drug interactions with warfarin include synergism, competitive antagonism, and alteration of the physiological control loop of vitamin K.
III - The most dangerous interactions with warfarin are those that increase the anticoagulant effect and the risk of bleeding.
a) Only I is correct.
b) Only II is correct.
c) Only III is correct.
d) I and II are correct.
e) I, II, and III are correct.
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Ed 
A alternativa correta é a letra D) I e II estão corretas. A interação medicamentosa com a varfarina pode ocorrer por mecanismos farmacocinéticos e farmacodinâmicos. Os mecanismos farmacocinéticos envolvem principalmente a indução da enzima P450 CYP2C9, inibição enzimática e redução da ligação às proteínas plasmáticas. Já os mecanismos farmacodinâmicos envolvem sinergismo, antagonismo competitivo e alteração do controle fisiológico da vitamina K. Portanto, as alternativas I e II estão corretas, enquanto a alternativa III é parcialmente correta, pois apenas menciona as interações mais perigosas, mas não especifica os mecanismos envolvidos.
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