What are the alterations in the cardiac action potential in hypertrophied myocardium? Stable excitability threshold and propagation parameters Prol...
What are the alterations in the cardiac action potential in hypertrophied myocardium?
Stable excitability threshold and propagation parameters
Prolongation of the action potential duration
Reduction in the maximum current of L-type calcium channels
Increase in the density of the inward current through the Na/Ca exchanger
The prolongation of the action potential duration is more important in models that produce concentric hypertrophy
The reduction in the maximum current of L-type calcium channels is due to the increase in the total membrane area
The reduction of the outward current through the Ito channel is implicated in the prolongation of the action potential duration in hypertrophied myocytes
The inward current through the Na/Ca exchanger contributes more to the prolongation of the action potential duration in advanced stages of hypertrophy
a) I and III are correct.
b) II and IV are correct.
c) I, II, and III are correct.
d) II, III, and IV are correct.
Stable excitability threshold and propagation parameters
Prolongation of the action potential duration
Reduction in the maximum current of L-type calcium channels
Increase in the density of the inward current through the Na/Ca exchanger
The prolongation of the action potential duration is more important in models that produce concentric hypertrophy
The reduction in the maximum current of L-type calcium channels is due to the increase in the total membrane area
The reduction of the outward current through the Ito channel is implicated in the prolongation of the action potential duration in hypertrophied myocytes
The inward current through the Na/Ca exchanger contributes more to the prolongation of the action potential duration in advanced stages of hypertrophy
a) I and III are correct.
b) II and IV are correct.
c) I, II, and III are correct.
d) II, III, and IV are correct.
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Ed 
A alternativa correta é a letra "d) II, III, and IV are correct." As alterações no potencial de ação cardíaco em miocárdio hipertrofiado incluem: prolongamento da duração do potencial de ação, redução na corrente máxima dos canais de cálcio do tipo L e aumento na densidade da corrente interna através do trocador Na/Ca. A redução da corrente externa através do canal Ito também está implicada no prolongamento da duração do potencial de ação em miócitos hipertrofiados.
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