What is the mechanism of action of pentavalent antimonials (Sb+5)? The pentavalent antimonials are considered to be bactericidal drugs, as they in...
What is the mechanism of action of pentavalent antimonials (Sb+5)?
The pentavalent antimonials are considered to be bactericidal drugs, as they interfere with the bioenergetics of the Leishmania parasite.
Both glycolysis and fatty acid oxidation, processes located in organelles, are inhibited by the pentavalent antimonials.
The exposure of amastigotes to pentavalent antimonials for 4 hours results in a decrease in certain substrates dependent on CO2.
The pentavalent antimonials stimulate the immune system of the infected individual.
The pentavalent antimonials are considered to be bactericidal drugs, as they interfere with the bioenergetics of the Leishmania parasite.
Both glycolysis and fatty acid oxidation, processes located in organelles, are inhibited by the pentavalent antimonials.
The exposure of amastigotes to pentavalent antimonials for 4 hours results in a decrease in certain substrates dependent on CO2.
The pentavalent antimonials stimulate the immune system of the infected individual.
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Ed 
O mecanismo de ação dos antimoniais pentavalentes (Sb+5) é a inibição da glicólise e da oxidação de ácidos graxos, processos localizados em organelas, o que interfere na bioenergética do parasita Leishmania. Esses medicamentos são considerados bactericidas e a exposição de amastigotas aos antimoniais pentavalentes por 4 horas resulta em uma diminuição de certos substratos dependentes de CO2. A afirmação "Os antimoniais pentavalentes estimulam o sistema imunológico do indivíduo infectado" não é verdadeira.
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