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Mind Maps
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Mind Maps
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Fisiopatologia
 Perda neuronal e a degeneração sináptica
Lesões principais:
 placas neuríticas (ou amiloides) 
 Emaranhados neurofibrilares.
Placas neuríticas são lesões extracelulares formadas pelo peptídeo beta-amilóide
Emaranhados neurofibrilares
Fisiopatologia
Originado a partir da clivagem da proteína precursora de amilóide (APP), proteína responsável por estimular o neurônio a crescer e se reparar em caso de lesão
a APP é clivada pela enzima alfa-secretase, transformada em fragmentos menores sem ação tóxica
 A Liberação do peptídeo beta-amilóide ocorre a partir da atividade das enzimas beta-secretase e gama-secretase
Resultando na agregação e deposição desse peptídeo no córtex
Interferir na sinapses
Lesões intraneurais compostas por elementos do citoesqueleto anormais
Proteína Tau
No citoesqueleto tem microtúbulos que realizam o transporte de substâncias no interior do neurônio 
Mantenham microtúbulos estáveis
Fosforilação anormal da proteína tau
Hiperfosforilada
Edema e distrofia dos microtúbulos e a consequente morte celular.
Mind Maps
JUPITER
NEPTUNE
MERCURY
VENUS
EARTH
MOON
VENUS
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Venus
Earth
Mars
Jupiter
Saturn
Neptune
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Opt. 4
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Opt. 5
Mercury
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Concept 2
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Concept 3
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MERCURY
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NEPTUNE
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VENUS
Venus has a beautiful name and is the second planet
Mind Maps
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VENUS
Venus has a beautiful name
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SATURN
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EARTH
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VENUS
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JUPITER
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MARS
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VENUS
Venus has a beautiful name
Mind Maps
JUPITER
VENUS
PLUTO
SATURN
MERCURY
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Venus
Neptune
Earth
Mars
Jupiter
Mercury
Callisto
Metis
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Moon
Uranus
Ganymede
SYSTEM
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Venus has a beautiful name
Pluto
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Mercury
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Mind Maps
MARS
Is a cold place
Mind Maps
VENUS
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Earth
Pluto
Moon
Venus
Venus
Pluto
Mars
Earth
Mind Maps
VENUS
Venus has a beautiful name and is the second planet
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