TCC FINAL

Prévia do material em texto

FACULDADE DA SAÚDE E ECOLOGIA HUMANA
PREVALÊNCIA DE COMORBIDADES EM PACIENTES INTERNADOS
COM COVID-19 QUE TIVERAM LESÃO AGUDA DO MIOCÁRDIO:
uma revisão bibliográfica
Vespasiano
2022
ANNA LAURA FRANÇA GONTIJO MENDES
ISADORA TEIXEIRA ISSA
KARENN TAVARES KIEPPER
TAMARA ARAÚJO PEREIRA CAMPOS
PREVALÊNCIA DE COMORBIDADES EM PACIENTES INTERNADOS
COM COVID-19 QUE TIVERAM LESÃO AGUDA DO MIOCÁRDIO:
uma revisão bibliográfica
Trabalho de Conclusão de Curso apresentado à Faculdade
da Saúde e Ecologia Humana, como requisito parcial para
obtenção do título de Bacharel em Medicina
Orientador(a): Profa. Jacqueline de Castro Laranjo
Vespasiano
2022
FICHA CATALOGRÁFICA
P944 Prevalência de comorbidades em pacientes internados com covid-19 que tiveram lesão
aguda do miocárdio: uma revisão bibliográfica. / Anna Laura França Gontijo Mendes... [et
al.]. – Vespasiano, 2022.
39 f.
Orientadora: Jacqueline de Castro Laranjo.
Trabalho de conclusão de curso (Medicina) – Faculdade da Saúde e Ecologia Humana –
FASEH, 2022.
Outros autores: Isadora Teixeira Issa, Karenn Kiepper Tavares, Tamara Araújo Pereira
Campos.
1. Covid-19. 2. Lesão cardíaca aguda. 3. Comorbidade. 4. Prevalência. I. Mendes, Anna
Laura França Gontijo. II. Issa, Isadora Teixeira. III. Tavares, Karenn Kiepper. IV. Campos,
Tamara Araújo Pereira. V. Faculdade da Saúde e Ecologia Humana. VI. Título.
CDD 616.2414
Figura 1: Ficha catalográfica elaborada por Flávio José dos Santos – Bibliotecário CRB 6/3168
FOLHA DE APROVAÇÃO
ANNA LAURA FRANÇA GONTIJO MENDES
ISADORA TEIXEIRA ISSA
KARENN TAVARES KIEPPER
TAMARA ARAÚJO PEREIRA CAMPOS
PREVALÊNCIA DE COMORBIDADES EM PACIENTES INTERNADOS
COM COVID-19 QUE TIVERAM LESÃO AGUDA DO MIOCÁRDIO:
uma revisão bibliográfica
Trabalho de Conclusão de Curso apresentado à Faculdade da Saúde e Ecologia
Humana como requisito para obtenção do título de Bacharel em Medicina.
FASEH (2022)
Vespasiano (2022)
______________________________________
Prof. Jaqueline de Castro Laranjo – FASEH ( Orientador)
______________________________________
Prof. – INSTITUIÇÃO
_______________________________________
Prof. – INSTITUIÇÃO
AGRADECIMENTO
O desenvolvimento deste trabalho de conclusão de curso contou com a ajuda de
diversas pessoas, dentre as quais agradecemos:
Aos professores orientadores, que durante 18 meses nos acompanharam
pontualmente, dando todo auxílio necessário para a elaboração do projeto. Em
especial, a Professora Jacqueline por ter aceitado ser a orientadora deste trabalho.
Aos professores do curso de medicina, que através de seus ensinamentos
permitiram que nós pudéssemos concluir este trabalho.
Aos nossos amigos da turma, pelos anos de convivência que serão lembrados para
sempre.
EPÍGRAFE
“A menos que modifiquemos a nossa maneira de pensar, não seremos capazes de
resolver os problemas causados pela forma como nos acostumamos a ver o
mundo”. (Albert Einstein)
RESUMO
Os primeiros casos de infecção causada pelo COVID-19 surgiram em dezembro de
2019, na China. Em março de 2020, a Organização Mundial de Saúde (OMS), diante
dos elevados índices de disseminação do COVID-19, declarou pandemia. Além de
manifestações multissistêmicas, tem-se observado que a infecção pelo COVID-19
pode levar à formação de injúrias cardíacas agudas ou ao agravo de patologias
cardiovasculares pré-existentes, sobretudo em pacientes internados. Para a
elaboração desta revisão narrativa, foram selecionados 157 artigos. Desses, 27
estudos preencheram os critérios de inclusão. Foram avaliadas as características
clínicas, os achados laboratoriais e o desfecho de pacientes com teste de PCR
positivo para SARS-Cov-2 que apresentaram elevação de troponina acima do
percentil 99 e, consequentemente, lesão cardíaca aguda. A idade avançada, acima
de 66 anos, sexo masculino e a presença de Hipertensão Arterial Sistêmica (HAS) ,
Diabetes Mellitus (DM) e dislipidemia se mostraram como variantes prevalentes nos
artigos. É importante ressaltar que como resultado obtivemos que, a 41,27% dos
pacientes vieram a óbito Ademais, a fim de se elucidar os mecanismos de lesão
miocárdica em pacientes com condições agudas e avançar no desenvolvimento de
estratégias para amenizar o mau prognóstico associado, faz-se necessário a
elaboração de estudos futuros.
Palavras-Chave: COVID-19. Lesão cardíaca aguda. Comorbidade. Prevalência.
SARS-Cov-2.
ABSTRACT
The first cases of infection caused by COVID-19 appeared in December 2019 in
China. In March 2020, the World Health Organization (WHO), faced with the high
rates of spread of COVID-19, declared a pandemic. In addition to multisystemic
manifestations, it has been observed that COVID-19 infection can lead to the
formation of acute cardiac injuries or the aggravation of pre-existing cardiovascular
pathologies, especially in hospitalized patients. For the elaboration of these narrative
reviews, 157 articles were selected. Of these, 27 studies met the inclusion criteria.
Clinical characteristics, laboratory findings and outcome of patients with a positive
PCR test for SARS-Cov-2 who presented an elevation of troponin above the 99th
percentile and, consequently, acute cardiac injury, were evaluated. Advanced age,
above 66 years old, male and the presence of systemic arterial
hypertension,diabetes mellitus and dyslipidemia shown to be prevalent variants in
the articles. It is important to emphasize that as a result, we obtained that 41.27% of
the patients died. Furthermore, in order to elucidate the mechanisms of myocardial
injury in patients with acute conditions and advance in the development of strategies
to alleviate the associated poor prognosis, it is necessary to carry out future studies.
Key-Words: COVID- 19. Myocardial injury. Comorbidity. Prevalence. SARS-Cov-2.
LISTA DE ILUSTRAÇÕES
FIGURA 1 – PRISMA (itens de relatório preferidos para revisões sistemáticas e meta
análises) fluxograma de inclusões e exclusões de estudos …………………..………10
LISTA DE TABELAS
TABELA 1 - Síntese e análise de dados …................................................................10
TABELA 2 - Prevalência de comorbidades …...........................................................17
LISTA DE SIGLAS
BRA - Bloqueador de Renina Angiotensina
BVS - Biblioteca Virtual de Saúde
CD4 - Linfócito do grupamento de diferenciação 4
CD8 - Linfócito do grupamento de diferenciação 8
CK-MB - Creatinofosfoquinase isoenzima MB
COVID-19 - Doença do Coronavírus 2019
DAC – Doença Arterial Coronariana
DCV - Doença Cerebrovascular
DM - Diabetes Mellitus
DPOC - Doença Pulmonar Obstrutiva Crônica
DRC - Doença Renal Crônica
ECA2- Enzima Conversora de Angiotensina 2
EUA - Estados Unidos da América
HAS - Hipertensão Arterial Sistêmica
IAM - Infarto Agudo do Miocárdio
IECA - Inibidores da Enzima Conversora de Angiotensina
IMC - Índice de Massa Corporal
LAM - Lesão aguda do miocárdio
LCA - Lesão Cardíaca Aguda
NT BNP- Peptídeo Natriurético Cerebral
PCR - Proteína C Reativa
SARS-CoV-2 - “severe acute respiratory syndrome coronavirus 2 ” - Síndrome
Respiratória Aguda Grave Coronavírus 2
SDRA - Síndrome da Angústia Respiratória
T2MI - Infarto do Miocárdio Tipo 2
UTI - Unidade de Terapia Intensiva
SUMÁRIO
INTRODUÇÃO 6
OBJETIVO 7
MATERIAL E MÉTODOS 8
Estratégia de pesquisa 8
Seleção de estudos 8
Extração de dados 9
RESULTADOS 9
DISCUSSÃO 19
CONCLUSÃO 27
REFERÊNCIAS 27
4
PREVALÊNCIA DE COMORBIDADES EM PACIENTES INTERNADOS COM
COVID-19 QUE TIVERAM LESÃO AGUDA DO MIOCÁRDIO: Uma revisão
bibliográfica
● Anna Laura França Gontijo MendesI; Isadora Teixeira IssaI; Karenn
Tavares KiepperI; Tamara Araújo Pereira CamposI; Jacqueline de Castro
Laranjo II;
I Acadêmicas de Medicina da FASEH, Vespasiano, MG, Brasil
II Doutora em Educação professora da FASEH, Vespasiano, MG, Brasil
RESUMO
Os primeiros casos de infecção causada pelo COVID-19 surgiram em dezembro de
2019, na China. Em março de 2020, a Organização Mundial de Saúde (OMS), diante
dos elevadosíndices de disseminação do COVID-19, declarou pandemia. Além de
manifestações multissistêmicas, tem-se observado que a infecção pelo COVID-19
pode levar à formação de injúrias cardíacas agudas ou ao agravo de patologias
cardiovasculares pré-existentes, sobretudo em pacientes internados. Para a
elaboração dessaa revisão narrativa, foram selecionados 157 artigos. Desses, 27
estudos preencheram os critérios de inclusão. Foram avaliadas as características
clínicas, os achados laboratoriais e o desfecho de pacientes com teste de PCR
positivo para SARS-Cov-2 que apresentaram elevação de troponina acima do
percentil 99 e, consequentemente, lesão cardíaca aguda. A idade avançada, acima
de 66 anos, sexo masculino e a presença de Hipertensão Arterial Sistêmica (HAS) ,
Diabetes Mellitus (DM) e dislipidemia se mostraram como variantes prevalentes nos
artigos. É importante ressaltar que como resultado obtivemos que, a 41,27% dos
pacientes vieram a óbito Ademais, a fim de se elucidar os mecanismos de lesão
miocárdica em pacientes com condições agudas e avançar no desenvolvimento de
estratégias para amenizar o mau prognóstico associado, faz-se necessário a
elaboração de estudos futuros.
Palavras-Chave: COVID-19. Lesão cardíaca aguda. Comorbidade. Prevalência.
SARS-Cov-2.
5
ABSTRACT
The first cases of infection caused by COVID-19 appeared in December 2019 in
China. In March 2020, the World Health Organization (WHO), faced with the high
rates of spread of COVID-19, declared a pandemic. In addition to multisystemic
manifestations, it has been observed that COVID-19 infection can lead to the
formation of acute cardiac injuries or the aggravation of pre-existing cardiovascular
pathologies, especially in hospitalized patients. For the elaboration of these narrative
reviews, 157 articles were selected. Of these, 27 studies met the inclusion criteria.
Clinical characteristics, laboratory findings and outcome of patients with a positive
PCR test for SARS-Cov-2 who presented an elevation of troponin above the 99th
percentile and, consequently, acute cardiac injury, were evaluated. Advanced age,
above 66 years old, male and the presence of systemic arterial
hypertension,diabetes mellitus and dyslipidemia shown to be prevalent variants in
the articles. It is important to emphasize that as a result, we obtained that 41.27% of
the patients died. Furthermore, in order to elucidate the mechanisms of myocardial
injury in patients with acute conditions and advance in the development of strategies
to alleviate the associated poor prognosis, it is necessary to carry out future studies.
Key-Words: COVID-19. Myocardial injury. Comorbidity. Prevalence. SARS-Cov-2.
6
INTRODUÇÃO
A pandemia causada pelo COVID-19 surgiu inicialmente em dezembro de 2019, na
cidade de Wuhan, província de Hubei, na China e sendo o agente etiológico o novo
coronavírus denominado “severe acute respiratory syndrome coronavirus 2”
(SARS-CoV-2) (ROMANO,2021). No Brasil, o primeiro caso de COVID-19 foi
confirmado no final de fevereiro de 2020. Em maio de 2022 o número de casos
passa de 30.594.388 e de óbitos confirmados de 664.390.RAS (BRASIL, 2021).
O SARS-CoV-2 vírus possui alta transmissibilidade e tempo de incubação entre 4 e
8 dias. A transmissão se dá, sobretudo, pelo contato direto e indireto com gotículas
respiratórias. Os sintomas mais frequentes incluem febre, fadiga, tosse seca,
mialgia, congestão das vias aéreas superiores, dor abdominal, anosmia e ageusia
(MARTINS et al, 2020). Além dos sintomas supracitados, assemelhando-se a outras
infecções respiratórias, fatores de risco e comorbidades pré-existentes podem
agravar a COVID-19, resultando em um possível agravamento das doenças
cardiovasculares crônicas, bem como ao aparecimento agudo de novas
complicações cardíacas (WU, 2020). É importante destacar que dentre as
complicações cardíacas evidenciam sobretudo a lesão cardíaca aguda, que pode
estar presente em aproximadamente 16% dos pacientes internados por COVID-19, e
leva a manifestações mais graves da doença. (WEI, at. al, 2020) .
Além disso, a COVID-19 apresenta manifestações multissistêmicas, sendo as
injúrias cardíacas agudas uma que merece destaque, visto que, pacientes com lesão
miocárdica internaram mais na unidade de terapia intensiva (UTI) (22,2% vs. 2,0%)
e apresentaram maior taxa de óbito (59% vs. 1%) sendo, por isso, importante
verificar a literatura para elucidar a ocorrência de lesões cardíacas agudas e as
variáveis associadas a sua ocorrência (COSTA, 2020).
7
OBJETIVO
O objetivo desta revisão narrativa é avaliar a prevalência fatores (comorbidades,
idade, sexo e alguns biomarcadores), que podem estar relacionados a pacientes que
desenvolvem lesão cardíaca aguda (LCA) associada a infecção pelo SARS-Cov-2.
8
MATERIAL E MÉTODOS
Estratégia de pesquisa
Realizamos pesquisas bibliográficas estruturadas nas bases científicas no PubMed,
no Cochrane Central Register of Controlled Trials e na Biblioteca Virtual em Saúde
(BVS), com os seguintes descritores: “adults”, “myocardial injury”, “risk factor”
“COVID-19”. As buscas abrangeram o período desde a data de criação de cada
banco de dados até 20 de março de 2022. Foram aplicados os filtros de artigos que
continham resumo, texto completo grátis, artigos que estavam disponíveis em inglês
ou português ou espanhol. Não foi aplicado nenhum desenho de estudo específico.
Com objetivo de identificar artigos que poderiam ter sido perdidos nas buscas, a
lista de referências de cada estudo selecionado foi revisada.
Seleção de estudos
Duas revisoras de forma independente e em duplicata, selecionaram os estudos a
partir de uma triagem realizada pelo título do estudo e do seu resumo. Os revisores
resolveram as divergências por discussão.
Incluímos estudos que apresentaram características de pacientes internados com
COVID-19 que apresentaram lesão aguda do miocárdio (LAM), caracterizada pelo
aumento da troponina acima do percentil 99.
Discriminadamente, compreendemos estudos que avaliaram pacientes com teste de
PCR positivo para SARS-CoV-2 que apresentaram elevação de troponina acima do
percentil 99 e, portanto, apresentaram LAM, que estavam internados em centros de
saúde e apresentavam dados relativos a comorbidades, achados laboratoriais e
mortalidade nestes pacientes. Excluímos estudos que não abordavam as
comorbidades dos pacientes, ou seja, abordavam somente taxa de mortalidade ou
achados laboratoriais. Quando o estudo apresentava as características dos
pacientes a partir da elevação do nível de troponina, usamos os dados referentes a
elevação acima do percentil 99. Selecionamos os seguintes biomarcadores como
9
alvo da nossa revisão: PCR, procalcitonina, D-dímero, CK-MB e NT-BNP, pois são
marcadores relacionados à lesão cardíaca aguda e infecção. Em pacientes
internados no hospital, os biomarcadores de estresse ou de lesão cardíaca e
inflamação são frequentemente anormais. Essa alteração parece se dar tanto pelo
dano miocárdico viral direto quanto pelo aumento do risco para ocorrência de
doenças cardiovasculares (PELLICORI, et al, 2021). Em vista, de não haver
padronização internacional de medidas, optamos por usar apenas biomarcadores
que tiveram aumento.
Extração de dados
Os estudos selecionados foram divididos entre dois pares de revisoras,
independentes que coletaram os seguintes elementos sobre as características do
estudo (ano de publicação, país, tipo de estudo e período de tempo que o estudo foi
realizado); características da população (tamanho da amostra, idade,
comorbidades); descrição dos achados laboratoriais e desfecho.
RESULTADOS
A Figura 1, ilustra o diagrama de fluxo de itens de relatório preferidos para revisões
sistemáticas e meta-análises (PRISMA). Nossa busca identificou 157 artigos, dos
quais incluímos 51 estudos para avaliação de texto completo. 27 estudos
preencheram os critérios de inclusão (apresentar comorbidades, definição de LCA
como troponina acima dopercentil 99 ou níveis de troponinas acima do percentil 99).
Esses 27 estudos, com amostras de 9 a 3219, envolveram um total de 8.215
pacientes e foram conduzidos em 7 países diferentes (China, EUA, Itália, Inglaterra,
Brasil, Espanha e Turquia), o primeiro o sendo avaliando pacientes em janeiro 2020
e o último terminado em janeiro de 2021.
10
Figura 1 - PRISMA (itens de relatório preferidos para revisões sistemáticas e meta
análises) fluxograma de inclusões e exclusões de estudos
Tabela 1 - Síntese e análise de dados
Número Autor Título Base de
dados
/Periódico
Periódico País/
idioma
Ano de
publicação
1 Bardají, et al Prognostic
implications
of
myocardial
injury in
patients with
and without
COVID-19
infection
treated in a
university
hospital.
BVS Rev Esp
Cardiol (Engl
Ed) 2021 ;
74(1): 24-32
Espanha
/
Espanho
l
2021
2 Barman, et al Prognostic
significance
of cardiac
Pubmed Coron Artery
Dis. 2021;
32(5):
Turquia/
Inglês
2021
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33144126&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JeqgOuEpDyXaoCD7un9QMcIAq8dPtsCe1PbQYQBDBWg%3D&reserved=0
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Rev%20Esp%20Cardiol%20(Engl%20Ed)
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Rev%20Esp%20Cardiol%20(Engl%20Ed)
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Rev%20Esp%20Cardiol%20(Engl%20Ed)
11
injury in
COVID-19
patients with
and without
coronary
artery
disease.
359-366
3 Briscoe, et al Clinical
significance
of
coronavirus
disease
2019 in
hospitalized
patients with
myocardial
injury
Pubmed Clinical
cardiology
2021; 44(3):
332–339
Inglaterr
a/ Inglês
2021
4 Cao, et al. Myocardial
injury and
COVID-19:
Serum
hs-cTnI level
in risk
stratification
and the
prediction of
30-day
fatality in
COVID-19
patients with
no prior
cardiovascul
ar disease.
BVS/
MEDLINE
Theranostics
2020;
10(21):
9663-9673
China/
Inglês
2020
5 Deng, et al The
diagnostic
and
prognostic
role of
myocardial
injury
biomarkers
in
hospitalized
patients with
COVID-19.
Pubmed Clinica
chimica acta
2020; 510 :
186-190
China/
inglês
2020
6 Efros, et al Myocardial
injury in
hospitalized
patients with
COVID-19
infection-Ris
k factors and
outcomes.
BVS/
MEDLINE
PLoS One
2021; 16 (2):
e0247800
Israel/
inglês
2021https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33501708%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891927034%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=%2FOsH0gqt6F5M4uKSEPpWvl2%2F9oX0Mx0mxMlwMMBU0bo%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32863952&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bB4auxPIRu62n6y8ZkH3NaWQQDQ5y4lOAs6BudiO%2BOk%3D&reserved=0
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Theranostics
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33635914&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=mat1NwLvJ2XsJOgB07g3KAjQ5W3NHvWaDDoQUHxNo0I%3D&reserved=0
12
7 Ferrante, et al Risk factors
for
myocardial
injury and
death in
patients with
COVID-19:
insights from
a cohort
study with
chest
computed
tomography
Pubmed Cardiovascul
ar research
2020;116(14)
: 2239–2246.
Itália/
Inglês
2020
8 Galea, et al T2-mapping
increase is
the prevalent
imaging
biomarker of
myocardial
involvement
in active
COVID-19: a
Cardiovascul
ar Magnetic
Resonance
study
Pubmed Journal of
cardiovascul
ar magnetic
resonance
2021; 23(1):
68.
Italia/
Inglês
2021
9 Guo, et al. Cardiovascul
ar
Implications
of Fatal
Outcomes of
Patients
With
Coronavirus
Disease
2019
(COVID-19)
Pubmed JAMA
Cardiol
2020;5(7):81
1-818
China/
Inglês
2020
10 He, et al Key factors
leading to
fatal
outcomes in
COVID-19
patients with
cardiac
injury
Pubmed Scientific
reports 2021;
11(1): 4144
China/
Inglês
2021
11 Huang, et al A novel risk
score to
predict
cardiovascul
ar
complication
s in patients
with
BVS Imun
Inflamm Dis.
2020; 8(4):
638-649.
China/
Inglês
2020
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32637999%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890989714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=uUhoMskNjGzQvPMWHAU%2FYnCn17acON4jr1XR5KlpiLw%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32219356%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651890364818%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=WqPSuxB0SvnMsRm%2Bc7VLSERLZ0zj7wY4p6kerrfu%2FD4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33602949%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=LEB42aM29L4bxPwO8mt5iZM81rOnzIhVVh5CWm2hFas%3D&reserved=0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537545/#
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537545/#
13
coronavirus
disease
2019
(COVID‐19):
A
retrospective
, multicenter,
observationa
l study
12 Lala, et al Prevalence
and Impact
of
Myocardial
Injury in
Patients
Hospitalized
With
COVID-19
Infection.
BVS/
MEDLINE
J Am Coll
Cardiol 2020
; 76(5):
533-546,
Estados
Unidos /
Inglês
2020
13 Lombardi, et
al
Association
of Troponin
Levels With
Mortality in
Italian
Patients
Hospitalized
With
Coronavirus
Disease
2019:
Results of a
Multicenter
Study
Pubmed JAMA
cardiology
2020;5(11):1
274–1280.
Itália/
Inglês
2020
14 Lorente-Ros,
et al
Myocardial
injury
determinatio
n improves
risk
stratification
and predicts
mortality in
COVID-19
patients.
BVS Cardiol J
2020 ; 27(5):
489-496
Espanha
/
Espanho
l
2020
15 Majure, et al Usefulness
of Elevated
Troponin to
Predict
Death in
Patients
With
COVID-19
and
Myocardial
Pubmed The
American
journal of
cardiology
2021; 138:
100–106
Estados
Unidos/
Inglês
2021
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=J%20Am%20Coll%20Cardiol
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=J%20Am%20Coll%20Cardiol
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32845276%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892551933%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=12HeZT6TDLOFfY%2FSdq0KhYNhGFeD9oHf7HH889dS58s%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-32589258&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=bxQLKKi1ruIP6AFyxTJIq7w0%2BaXH5PfJXL42t9TetCQ%3D&reserved=0
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Cardiol%20J
http://portal.revistas.bvs.br/transf.php?xsl=xsl/titles.xsl&xml=http://catserver.bireme.br/cgi-bin/wxis1660.exe/?IsisScript=../cgi-bin/catrevistas/catrevistas.xis%7Cdatabase_name=TITLES%7Clist_type=title%7Ccat_name=ALL%7Cfrom=1%7Ccount=50&lang=pt&comefrom=home&home=false&task=show_magazines&request_made_adv_search=false&lang=pt&show_adv_search=false&help_file=/help_pt.htm&connector=ET&search_exp=Cardiol%20J
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
14
Injury
16 Mei, et al Risk factors
for
myocardial
injury at
admission of
325 patients
with
coronavirus
disease
2019 in
Shanghai,
China
Pubmed Australasian
journal on
ageing 2021;
41(1):
e50-e57
China/
Inglês
2021
17 Michieli, et al Using high
sensitivity
cardiac
troponin
values in
patients with
SARS-CoV-2
infection
(COVID-19):
The Padova
experience
Pubmed Clinical
biochemistry
2021; 90:
8–14.
Italia/
Inglês
2021
18 Michieli, et al High-Sensiti
vity Cardiac
Troponin T
for the
Detection of
Myocardial
Injury and
Risk
Stratification
in
COVID-19.
Pubmed Clinical
chemistry
2021; 67(8):
1080–1089.
Estados
Unidos /
Inglês
2021
19 Nascimento,
et al
COVID-19
and
Myocardial
Injury in a
Brazilian
ICU: High
Incidence
and Higher
Risk of
In-Hospital
Mortality. /
COVID-19 e
Injúria
Miocárdica
em UTI
Brasileira:
Alta
Incidência e
BVS Arq Bras
Cardiol 2021
; 116(2):
275-282
Brasil/
portuguê
s
2021
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33058800%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892083294%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=Xwhns4FhuwRpCTPwZ6LfQeik30A6bKEwhOTdP30%2Bbh4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34668629%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651892395714%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=j27BhTZZku6oQ8bjQ%2BF8%2FCngK4689d6prbT%2BTI9fdsE%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33529580%2F&data=04%7C01%7C%7Cf37af74f90784e3704fe08da119a573c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841651891614598%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=f0Fu4C4wm%2BguwHkzbamllIwz0BMvDkEwCq%2BlQq%2FjRns%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpesquisa.bvsalud.org%2Fportal%2Fresource%2Fpt%2Fmdl-33470333&data=04%7C01%7C%7C140753ce542f443d866608da119da9ed%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637841666139907815%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YfMGhPei1z0OsIFZpHnKnkgj7oQpdfJqw0CHISxPhT4%3D&reserved=0