empower_functionality_rev_2

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. . . . . . . . . .
. . . 
. tion 
oftware 
Functionality 
 
 
April, 2004 
. . .. . . Waters Corpora
Empower S
 
nts 
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Where Do The Dates Come From? ...................................................................................................... 
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Instrument Server ................................................................................................................................. 10 
Database Server ................................................................................................................................... 11 
Processing Server................................................................................................................................. 1 
SECTION 3 – FUNCTIONALITY ............................................................................................................. 1 
Definitions ................................................................................................................................................. 1 
Empower General Description ................................................................................................................ 2 
Configuration Manager ........................................................................................................................... 3 
Projects................................................................................................................................................... 4 
Table Of Conte
 
SECTION 1 - INTRODUCTION.................................................................................... .. ..
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Basic Principles............................................................................................................. .. ..
What Makes Empower Unique? ................................................................................. .. ..
Multiple User Interfaces............................................................................................. .. ..
Central Database........................................................................................................ .. ..
Features ................................................................................................................. ..
Benefits .................................................................................................................. ..
Security & Regulatory Compliance ............................................................................ .. ..
Features ................................................................................................................. .. ..
Benefits .................................................................................................................. .. ..
Component-Based Architecture.................................................................................. .. ..
Features ................................................................................................................. .. ..
Benefits .................................................................................................................. .. ..
Scalable Architecture ................................................................................................. .. ..
Features ................................................................................................................. ..
Benefits .................................................................................................................. ..
Empower Scalability Strategy ..................................................................................... .. ..
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ECTION 2 - TECHNOLOGY....................................................................................... .. ..
Licenses & Key Disks ..................... ............................................................................. .. ..
Named User License Key Disks.................................................................................. .. ..
Base Key Disks ........................................................................................................... .. ..
Client/Server and Workstation Specific Option Disks ................................................ ..
Options Not Requiring Key Disks............................................................................... ..
The Waters Service....................................................................................................... .. ..
How Operating System (OS) Security Works ............................................................. .. ..
How Operating System (OS) Services Work............................................................... .. ..
Data Acquisition and Buffering................................................................................... .. ..
How Oracle and Server Failures are Recognized ..................................................................................
Local Directory and File Organization...................................................................... .. ..
How Identifiers are Assigned ..................................................................................... ....
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Empower & Date Handling ........................................................................................ ..
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How Empower Handles Dates................................................................................... ..
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Oracle Date Format .................................................................................................. ..
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Microsoft Date Format............................................................................................... ..
..Empower Use of Oracle Tablespaces..........................................................................
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Application Components.............................................................................................. ..
Empower ‘Servers’....................................................................................................... ..
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... ......................Methods, 
r ds are stored in a reserved area of tablespace within the Empower database, 
b ive. 
ro cts 
 user-defined collection of methods, results, peaks, custom fields, peak
at are related and th
esults, and custom fiel
ut raw data are stored in a separate area on the hard dr
Function 
Project raw data can be sto
appropriate privilege. 
 Projects may be locked. 
 Projects may have the following actions performed on them: 
Open 
Backup and Restore 
Create, Clone and Delete 
Rename and change Properties 
 All actions performed on projects are tracked in the System Audit Trail. 
 One or more projects may be restored a
 
 red in multiple locations determined by users with the 
t one time. 
 One or more projects may be backed up at one time. 
 During backup, the project name, backup comments, backup type, user who performed the 
backup, date and time of backup, current project quota and current free space are 
serialized into a file which is part of the backup set. 
 During backup, the version of software in which the project was backed up is tracked. 
Upon restore, the version from the backup is documented in the System Audit Trail entry. 
 Empower does not require a specific backup utility but the user has the option to 
configure a backup utility into the backup process. 
 3-4 Waters Corporation 
 Empower Functionality 
3 ject backup will take all information within a project and place it in a specified Pro
location. 
 Project restore will take all information from a backup set and restore the project to the 
state at which it was at the time of backup. 
 Projects may only be deleted from the Empower database by a user who
Project” privilege. 
 has the “Delete 
 Audit trail setting must be configured when a project is created. These settings cannot be 
altered after creation is complete. 
 When a new project is created, the maximum size a project can grow to must be set. 
 Access to a project may be limited to the project owner, a specified set
the
 of user groups or 
 project may be available to all users. 
 If access to a project is given to a group or to all users, the access can b
specified set of privileges or can be wha
e limited to a 
tever privileges the particular user has for their 
account. 
 When a new project is created, specified information on methods, custom fields and/or 
te project. views can be copied from another, templa
 The owner of a project can be changed. 
 The current space taken by the project can be viewed. 
 Options can be enabled or disabled on a project basis. 
 Custom fields can be added, modified or deleted from projects. 
 Which users or groups have access to the project can be changed. 
 The maximum allowed space the project is allowed to use can be increased or decreased. 
 A “Number of Digits of Precision Displayed for Area and Height” se
control the precision used for the following fields: Minimum Area 
parameters of the processing method, Area, Height, Start height and End 
Area, Slice Area
tting is available to 
and Minimum Height 
Height, Total 
 (GPC), Slice Height (GPC), Area Rejection (located in Table properties 
ents table of a 
as a precision of 
r 3 or the number specified in the “Number of Digits of Precision for Area and 
ing detectors that 
 small signals. 
of a reporting table group), and the Value field in the Integration Ev
processing method. (The Value field in the integration events table h
eithe
Height” field, whichever is greater.) This feature is designed for those us
yield very
 Software options can be enabled/disabled during project creation in the New Project 
Wizard – Options page. 
 If a single project is selected, multiple copies of the project can be create
operation. 
d in a single 
 If multiple projects are selected, a single copy of each project will be created with a single 
tion. opera
er is an ind
at control the level of access to functions in Empower software. 
 Function 
 User accounts may be set to one of the following three status conditio
Active 
 
Users 
A us ividual with access to the Empower system. Users have accounts and privileges 
th
ns: 
Disabled 
Removed 
 Only “Active” user accounts may be used to login to the Empower application. 
 A user account may include the full name of the user. 
 User accounts may require a password to be used when logging in. 
 Each user account must be assigned privileges based on a specific user type. 
 There is no limit to the number of users that can be created provided that an adequate 
number of user licenses have been installed. 
 3-5 Waters Corporation 
 Empower Functionality 
3 are user (QuickStart, Pro, Open Access, Web, and System Default) can be Allowed softw
defined for each user. 
 A default user interface can be defined for each user. This interface will
defa
 be logged into by 
ng the Advanced 
. Note: For databases upgraded to Empower from 
Millennium , the default user interface is set to Pro. For new installations of Empower, 
the default user interface is set to QuickStart. 
ult for that user unless the user selects a different interface by clicki
>> button in the Login Dialog box
32
 
User Groups 
A is a set of users with access to the same projects. Members of a user group are 
di
 user group
splayed in the User Groups view of the Configuration Manager. 
 Function 
 A Group Administrator that can modify users only in their group can be defined. 
 User groups are supported to simplify assigning access to projects and acquisition servers. 
 There is no limit to the number of User Groups that may be defined. 
 
User Types 
A e is a way of characterizing users and specifying the access privileges for that Empower 
s ser. When you create a new user account, you provide access privileges to the new user 
b stomizable, and there is no limit 
to
 user typ
oftware u
y assigning a user type to that user. User types are completely cu
 the number of user types you can create. 
 Function 
 User Types are supported to define access privileges for individual users. 
 There
isition Servers 
n Acquisition Server is a device (usually containing a busLAC/E or serial card
f chrom
 Function 
 When an acquisition server is defined, access to that acquisition server 
system owner only, to the ow
may be given to the 
ner and selected user groups or to all users. 
 Up to 4 computer serial (COM) ports may be used to connect instruments to an acquisition 
server. 
 Up to 8 serial ports on an Equinox Serial Card may be used to connect instruments to an 
acquisition server. 
 An acquisition server may be password protected to prevent unauthorized reconfiguration. 
 An acquisition server can connect to a chromatographic instru
 is no limit to the number of User Types that may be defined. 
 
Acqu
A ) that is capable 
o atographic instrument control and data acquisition. 
ment using IEEE or serial 
connection (depending on the device). 
 IEEE instrument connection is done using the Waters Bus LACE card. 
 You can control up to four simultaneously online HPLC or GC systems in an Empower 
Personal workstation or a Workgroup/Enterprise acquisition client. 
You can control up to eight simultaneously online HPLC or GC systems when using a 
LAC/E32 acquisition server. 
Note: These system limits are the total allowed for all interfaces – busLAC/E, 8-port serial 
card, and COM port. More than one interface can be run simultaneously. 
 
 3-6 Waters Corporation 
 Empower Functionality 
3 atographic instruments, such as a pump, autosampler, and detector, that 
f ther to produce data. 
Systems 
A system is a set of chrom
unction toge
 Function 
 Individual chromatographic instrument components may be configured
syste
 into a Empower 
m. 
 There are no limits to the number of chromatographic systems that can be configured in 
Empower. 
 Instrument components may be used in more than one Empower system. 
 Empower systems can be defined as ‘On-Line’ or ‘Off-Line’. 
 Only ‘On-Line’ systems can beused to run samples. 
 ‘Off-Line’ systems can be used to hold definitions of systems that may
actively configured to run sa
 not currently be 
mples or may be systems that are not currently connected and 
powered on an Empower acquisition server. 
 A System cannot be taken ‘Off-Line’ if any users are currently connected to it or if the 
system is currently acquiring samples. 
 A System cannot be brought ‘On-Line’ if any of the components in the system are 
t is not currently currently configured in another ‘On-Line’ system or if any componen
available. 
When an
given to t
Chromato
Em
515(PCM)
525 
600 
Empower 
410 
474 
2487
2410 
996 
2996 
Empower controls 
717 
2690/2695/269
2790/2795 
 chromatographic system is defined, access to that acquisition server may be 
he system owner only, to the owner and selected user groups or to all users. 
 graphic systems may be password protected to prevent unauthorized access. 
 power controls the following Waters HPLC pumps and solvent management systems:
501(PCM) 
510(PCM) 
 
(PCM) 
625 
626 
2690/2695/2690D 
2790/2795 
 controls the following Waters HPLC detectors: 
486 
 
 the following Waters HPLC autosamplers: 
0D 
 Empower controls the following non-Waters equipment: 
Agilent 5890 GC 
Agilent 7673 GC Autosampler 
Agilent 6890 GC 
Agilent 1100 system 
 Empower controls the following other equipment 
Waters ZQ 2000/4000 
 When using a controlled autosampler, the system automatically captures all vial 
 3-7 Waters Corporation 
3 tions. If a non-
rm vial number. 
 Empower Functionality 
information, including number, position, volume, and number of injec
controlled autosampler is used, BCD input may be configured to confi
 Column temperature may be controlled through the use of integrated column heaters in 
n heater attached to the 600, 625, 626, 2690, 2790, or through the use of an external colum
a 410 or 2410 detector. 
 More than one detector may be configured in a single chromatography system. These 
rough their detectors will use the same time base, and will be related to each other th
injection ID. 
 Multiple detector channels from the same injection may be processed as a unit, using the 
splayed on screen 
ion and entering review. The channels may also be 
ction. 
same or different processing parameters. The channels may also be di
by selecting their common inject
included on the same report by creating a summary report based on inje
 Data acquisition rates available are 0.25, 1, 2, 5, 10, 20, 25, 50, or 100 da
second, depending on
ta points per 
 detector capabilities. 
 Controlled instruments with digital data collection can handle the full dynamic range of 
the detectors. Analog instruments will connect to a SAT/IN interface, which can handle a 
range from –0.25 – 2.25 volts. 
 
 3-8 Waters Corporation 
 Empower Functionality 
3 tions in several 
e need to type 
efault strings, you can select them from a 
d st box in the functional area in which they are available. 
Default Strings 
Default Strings are phrases or series of words that are used as default text selec
Empower categories that you specify. Default strings save time by eliminating th
recurring comments and descriptions. After you create d
rop-down li
 Function 
Default strings can be created to 
the Empower ap
Changes to System Obje
Component Names 
Custom Field Revision Com
Deletion Comments 
Export method Revision Com
Generic Method Revision
Instrument method Revisio
Manual calibration
Manual result revisi
Method Set Revision Commen
Report Method Revision Com
Result Signoff 1 Meanings 
Result Signoff 2 Meanings 
Sample Information Revision Comments 
Sample Set Method R
Sample Set Method Template Revision
 minimize the typing required in the following sections of 
plication: 
cts Comments 
ments 
ments 
 Comments 
n Comments 
 revision Comments 
on Comments 
ts 
ments 
evision Comments 
 Comments 
 Where default strings can be selected within the application, the user will have the option 
to type a response that is not available in the default string list. 
 The default string drop down list is initially blank (to prevent the use
clicking OK to accept the default). 
r from simply 
 Spaces only are not allowed for an audit trail comment. 
 
Privi
P e the authority assigned to a user to access specified Empower software screens 
a r application. The 
u
leges 
rivileges ar
nd/or functions. Each privilege defines an allowed action within the Empowe
ser type assigned to a user account determines the available privileges. 
 Function 
 Privileges are defined to limit access to different functions or sections of the Empower 
application. 
 Privileges are sufficiently granular to ensure that object (item) creation, modification and 
deletion can be set separately. 
 Privileges are based on functions that can be performed and not on user interface elements 
of the software. This minimizes the complexity of configuration. 
 Privilege settings are not required based on operating system settings or disk structures. 
 The “Administrator” privilege assigns all Empower privileges to a user. 
 The “Archive and Remove Audit Trails” privilege specifies that a user can archive and remove 
System Audit Trail records and save them as binary or text files. Archiving and removing audit 
trail records requires two Administrator user names and passwords. 
 The “Remove Sample Archives” specifies that a user can archive and remove project/sample 
records in binary or text format. 
 The “View Audit Trails” privilege allows a user to view the System Audit Trail, which tracks 
changes to system-related information. 
 3-9 Waters Corporation 
3 archive the System 
 Audit Trail. 
 Empower Functionality 
 The “Archive System Audit Trails” privilege specifies that a user can
Audit Trail in binary or text format. The user can not remove the System
 The “Clear/Restore Offline Audit Trails” privilege specifies that a user can remove and/or 
t. Records cannot be restore archived System Audit Trail records from a binary file forma
restored from a text file format. 
 The “Clear/Restore Offline Archives” privilege specifies that a user can r
restore all entries from the offlin
emove and/or 
e project and sample archives. 
 The “Restore Archives” privilege specifies that a user can restore projects
backed up using the AutoArchive utility. 
 that have been 
 The “Paste Shallow Copies” privilege specifies that a user can paste sha
Shall
llow copied fields. 
ow pasted files contain only the current version of a method. A full audit trail 
ilege and the 
on-FAT Projects into FAT Projects” is 
project does not accept a shallow copied file unless the user has this priv
system policy “Don’t Allow User to Copy from N
turned off. 
 The “Lock Channels” and “Unlock Channels” privileges specify that a user can lock data 
channels, and/or unlock data channels, in the Project window. 
 The “Alter Custom Fields”, “Create Custom Field” and “Delete Custom Field” privileges 
power database. specify that a user can modify, create and/or delete a custom field in the Em
 The “Alter Default Strings”, “Create Default Strings” and “Delete Default Strings” 
ngs in the 
atabase. 
privileges specify that a user can modify, create, and/or delete default stri
Empower d
 The “Alter Plate Type”, “Create Plate Type” and “Delete Plate Type” priv
that a user can modify, create, and/or delete plate types in the Empowe
ileges specify 
r database. 
 The “Alter System Policies” privilege specifies that a user can alter system p
Empower database. 
olicies in the 
 The “Alter Projects”, “Create Projects” and “Delete Projects” privileges allo
all properties (nam
w a user to modify 
e, quota, access, custom fields, and so on) of a project, create a project or 
delete a project from the Empower database. 
 The “Backup Projects” and “Restore Projects” privileges allow a user to archive and/or restore 
a previously archived project. 
 The “Change ProjectOwner” privilege specifies that a user can change the
in the Empower database. 
 owner of a project 
 The “Change Project Quota” privilege specifies that a user has a restric
Alter Projects privilege, allowing the user to change only the database tablespace quota of 
ted form of the 
a project to which the user has access. 
 The “Create Project Path” privilege specifies whether the user has ac
Data Files from the View menu of Configuration Manager. The user with
cess to Manage Raw 
 this privilege 
can create a new data path to store project information. 
 The “Change Project Path” privilege allows the user to specify a project path other than 
he Move Project the default when modifying a project. The new data path is defined in t
Data dialog box. 
 The “Specify Project Path” privilege allows the user to specify a project path other than 
t and has this 
g the path from a list 
the default when creating a project. When the user creates a new projec
privilege, he can designate where the project data is stored by selectin
box. 
 The “View Multiple Projects” privilege specifies that a user can open 
projects in a single Project window. 
and view multiple 
 The “Alter Users”, “Create Users” and “Delete Users” privileges specify that a user can 
change the properties of another user, create a new user or permanently remove a user 
from the Empower database. 
 The “Alter User Type”, “Create User Type” and “Delete User Type” privileges specify 
that a user can change the properties (name and privileges) of a user type, can define a 
new user type or can permanently remove a user type from the Empower database. 
 The “Alter User Groups”, “Create User Groups” and “Delete User Groups” privileges 
specify that a user can change the members of a user group, create a new user group or 
 3-10 Waters Corporation 
3 
 Empower Functionality 
permanently remove a user group from the Empower database. 
 The “Delete Calibration Curves” and “Save Calibration Curves” pr
user
ivileges specify that a 
 can permanently remove from and/or save a calibration curve to the Empower 
database. 
 The “Delete Data” privilege specifies that a user can permanently rem
chromatographic data, such as injections, channels
ove 
, and so on, from a project. 
 The “Export Data” and “Import Data” privileges specify that a
and/or import data from a folder or device in a specified format. 
 user can export data to 
 The “Delete Libraries” and “Save Libraries” privileges specify that a user can 
 database. permanently remove and/or create and modify libraries in the Empower
 The “Rename Libraries” privilege specifies whether the user can 
PDA 
change the name of a 
or MS library. 
 The “Delete Export Methods” and “Save Export Methods” privileges specify th
can permanently remove and /or can save methods used to export data to
at a user 
 another 
application. 
 The “Delete Instrument Methods” and “Save Instrument Methods” privil
a user can permanently remove and/or save instrumen
eges specify that 
t methods used for data acquisition. 
 The “Delete Locked Methods” privilege specifies that a user can perman
from the Empower database any methods (locked or unlocked). 
ently remove 
 The “Lock Methods” privilege specifies that a user can lock any methods
database. Once you lock a method, you cannot unlock or modify it
 in the Empower 
. 
 The “Delete Processing Methods” and “Save Processing Methods” privi
a user can permanently remove and/or save processing methods used for 
leges specify that 
data reduction. 
 The “Delete Reporting Methods” and “Save Reporting Methods” privileges specify that a 
 or preview user can permanently remove and/or save report methods used to report
results. 
 The “Modify Report Scaling Only” privilege specifies that the user has the ability to edit 
thods) for printing the Scaling tab for plots that are part of a method (including locked me
or previewing. 
 The “Modify Default Report Methods” privilege specifies that the user h
customize default report methods using th
as the ability to 
e Edit > Manage Defaults menu in the Report 
Publisher. 
 The “Modify Default Report Groups” privilege specifies that the user has the ability to 
n the Report customize default report groups using the Edit > Manage Defaults menu i
Publisher. 
 The “Clear Read Only Methods” privilege specifies that a user can clea
only status while another user is editing the method. 
r a method's read-
 The “Save Methods as Current” privilege specifies that a user can save a
of a method as t
n earlier version 
he current version. 
 The “Delete Sample Set Methods” and “Save Sample Set Methods” pri
a user can permanently remove and/or save sample set methods used to 
when to acquire from each vial in a set of vial
vileges specify that 
define how and 
s. 
 The “Delete Sample Set Method Templates” and “Save Sample Set Meth
privileges specify that a user can permanent
od Templates” 
ly remove and/or save sample set method 
 will change templates used to predefine specific sample set parameters that you know
relatively infrequently. 
 The “Delete Method Sets” and “Save Method Sets” privileges specify that a user can 
permanently remove and/or save method sets used to define a collection of methods 
(instrument, processing, report, and/or export methods) and channels of data that control 
data acquisition, processing, reporting, and data exporting. 
 The “Delete 3D After Processing” privilege specifies that a user can permanently remove 
the 3D data associated with a PDA or MS data channel. 
 The “Modify Integration Parameters” privilege allows the user to open existing processing 
methods and make changes to the integration parameters and integration events in the 
Integration tab of the method. 
 3-11 Waters Corporation 
 Empower Functionality 
3 o open existing 
pr hanges to the following component parameters: 
e Retention Time 
n Time Window 
st fields 
 Window 
 The “Modify Component Parameters” privilege allows the user t
ocessing methods and make c
Component tabl
Retentio
RT Window % 
7 CConst fields 
Component Values in the Default Amounts tab 
Start and End times of a peak group 
Slicing tab (GPC) Retention Time, RT Window and 7 CCon
Calibration tab (GPC) Reference Peak Retention Time and RT
 The “Copy To Projects” privilege specifies that a user can copy information from one 
project into another project. 
 The “Delete Results” and “Save Results” privileges specify that a user can permanently 
remove from and/or save results in the Empower database. 
 The “Sign Off Results 1” and “Sign Off Results 2” privileges specify that a user can fill in 
the respective sign-off field in a result. 
 The “Specify Report Methods for Sign Off” privilege specifies that a user ca
report method
n indicate which 
s are required for signoff. 
 The “Alter Sample” privilege specifies that a user can change informat
contents of a vial after an injection from that
ion about the 
 vial has been made. 
 The “Save View Filters” privilege specifies that a user can save view filters created in the 
Project window. 
 The “Make View Filters Public” privilege specifies that a user can create or change the 
access type of a view filter to make it public or private. 
 The “Acquire Samples” privilege specifies that a user can acquire data from a sample set 
method in Run Samples. 
 The “Edit Sample Sets” privilege specifies that a user can modify existing sample set 
methods in Run Samples or in the Sample Set Method Editor. 
 The “Reinject Samples” privilege specifies that a user can reinject indi
sample set methods that have been 
vidual samples or 
previously acquired in Run Samples. 
 The “Allow Interactive Sys Changes” privilege specifies that a user
change pump parameters in Ru
 can interactively 
n Samples. 
 The “Alter Running Sample Sets” privilege specifies that a user can modify a sample set 
method while it is being acquired in Run Samples. 
 The “Access Real time Plot fromOpen Access” privilege specifies that th
access the Real Time Plot from Open Access. 
e user can 
 The “Alter Any Queue” privilege specifies that a user can rearrange any jobs in the 
Sample Sets table queue in Run Samples. 
 The “Alter My Queue” privilege specifies that a user can rearrange his/her jobs in the 
Sample Sets table queue in Run Samples. 
 The “Warn on Service Limit” privilege specifies that, if a user tries to use Run Samples 
when an instrument in the chromatographic system is past its service date limit, the user is 
warned but allowed to continue. In this case, a user without this privilege cannot acquire 
data in Run Samples. 
 The “Use Wizard Templates” privilege specifies that a user can create a sample set 
method from a sample set method template (which you create using the Sample Set 
Method wizard). 
 The “Allow Remote LAC/E Reboot” privilege specifies that the user can remotely reboot 
a LAC/E32 acquisition server from Configuration Manager. 
 
 3-12 Waters Corporation 
 Empower Functionality 
3 Plates 
te used for 
ntains wells 
 for injection. The plate type is the definition of both the overall plate and 
the wells contained within them. The terms plate and well can also be defined as rack and bottle, 
c vial, and so on. 
A plate type defines the physical and referential characteristics of a sample pla
injections by an instrument such as a Waters 2790 Separations Module. A plate co
that hold the samples
arousel and
 Function 
 Plate types can be created, modified and saved to the database. 
 Plate configuration property sheets graphically display what a plate of a specified type 
looks like and will show the effects of any parameter changes immediately. 
 Users can not modify or delete the predefined plates in Configuration Manager. 
 
A library is a user-created or commercial collection of PDA and/or MS spectral data collected 
f pectra, you may 
b ponents. 
Libraries 
rom known compounds. By comparing spectra from unknown peaks to library s
e able to identify the unknown com
 Function 
 The software supports integrated MS searching for the Wiley or Wiley and NIST libraries. 
 Libraries can be archived and restored. 
 Libraries may be imported and exported. Importing a library will allow the spectra in the 
import library to be merged into an existing library. 
 Spectra may be merged with a specified spectrum library. 
 
Mess g
T ssage Center is a run time log that temporarily stores temporary, system-level messages. 
T s related to 
E
a e Center 
he Me
he Message Center displays informational, warning, error, and fatal message
mpower system operation. 
 Function 
 The Message Center is located in the Microsoft Windows 2000 or Window
Tra
Th
been v
Messages
The purg
 The Message Center may be refreshed manually to ensure that all messages are displayed. 
 The Message Center Window displays information in a tabbed table using the following 
All 
General 
Acquisition 
Security 
Processing 
sections: 
s XP System 
y. 
 e Message Center icon appears in red when there are messages present that have not 
iewed. Normally, the icon appears in blue. 
 may be saved to a file for archival and transmission. 
 e capability of the Message Center may be password protected. 
 The Message Center may be purged to minimize storage required. 
 Sections of the Message Center may be purged individually. 
 The Message Center can be purged automatically after a user specified number of days. 
 3-13 Waters Corporation 
 Empower Functionality 
3 may be forced on top of other windows if an error has occurred and The Message Center 
the users needs to be notified. 
 The Message Center displays informational, warning, error, and fatal messages related to 
Empower system operation. 
 Messages are displayed in order of date and time. 
 New messages are added to the bottom of the list. 
 
Sys
T nitor application allows you to monitor system database usage in real time. 
I in table form. 
tem Monitor 
he System Mo
nformation on users, projects, systems, and processing servers is displayed
 Function 
 The System Monitor application allows you to monitor system data
time. Information on users, projects, systems, and processing server
base usage in real 
s is displayed in table 
form. 
 The number of licensed users and the num
The user ma
database (users, systems, projects or processing se
The frequency of display update can be set 
The User view will display the following information: 
The user n
Which computers (if any) the user is c
Which projects (if any) the user curren
Which systems (if any) the user is curren
The System view will displa
The system name 
hat is currently runninThe computer t
The user (if any) for whom data is being 
The project (if any) into which data is being ac
The current activity of the system 
The names of any other users who are view
The Project view displays the following informa
The name of the project 
The users (if any) who ar
ber of currently logged in users are shown. 
 y select to show only objects in use or to show all objects defined in the 
rvers). 
 by the user 
 
ame 
urrently logged in to 
tly has open 
tly acquiring data from 
 y the following information: 
g the system 
acquired 
quired 
ing the system 
 tion: 
e currently using the project 
The systems (if any) that are acquiring data into the project 
The available free space and allocated space for the project 
 The Processing view will display the following information: 
The name of the computer running the processing server 
he user (if any) who is running the processing server T
The name of the project for which data is being processed 
The status of the processing server 
 
Installation 
 Function 
 Named user license key disks will be used during installation to define the maximum 
number of users configured in the database. 
 An installation of the server can be either automatic or custom. 
 The user will be allowed to choose which, if any, acquisition device drivers are loaded. 
 3-14 Waters Corporation 
 Empower Functionality 
3 ilable in different capacities to facilitate ease of Named user license key disks are ava
installation and incremental removal of licenses. 
 Migration from the previous version of Millennium32 software will allow for the database 
to be migrated to the new version. 
 Option disks for Enterprise and Workgroup installations will act
for all
ivate the specified option 
 users of the database. 
 Empower uses the industry-standard InstallShield software to perform
installation. 
 software 
 Options key disks will be used during installation to define which optional Empower 
 the system (e.g. System suitability, PDA etc.). components should be activated on
Option and license key disks may be uninstalled. 
The following software options are available: 
P
MS (this option is 
GPC
GPC/V 
GPC/V/Light Scattering 
Dissolution 
Pattern
Open Access 
Toolkit (Empower programming user interface) 
Chemical Structures 
 
 
System suitability 
DA (this option is built in and does not require a key disk) 
built in and does not require a key disk) 
 
 Matching 
(this option is built in and does not require a key disk) 
Agilent 1100 
AutoArchive 
WebServer (this option is built in and does not require a key disk) 
 An data upgrade path is available between applications versions. 
 Installation may be split across multiple disk drives. 
 
Custom Fields 
ere are two types: 
• Custom Sample identifiers 
ds) 
ed by the 
power software default identifiers (such as, SampleName, SampleWeight, Dilution, Lot 
For example, you may want to identify samples with respect to lot number, dissolution medium, 
nd so on. You 
iers. 
 
Custom Database Results (Peak, Result, Component and Distribution Type, calculated custom 
fields) 
Custom database results to calculate a specific database result that is not already provided by 
Empower software. 
 
For example, you may want to calculate the ratioof two peaks’ areas or determine the total area 
of all peaks with a % Area less than 2% or convert the amounts reported in Empower to different 
units. 
Empower software allows you to create your own custom fields of which th
 
• Custom Database results 
 
Custom Sample Identifiers (Sample and Sample Set Type custom Fiel
Custom sample identifiers to describe an acquired sample beyond what is provid
Em
Number, Manufacturing Site and so on). 
 
storage interval, storage conditions, plant number, manufacture date, supplier, a
can associate such information with your samples by using custom sample identif
 3-15 Waters Corporation 
3 
 Empower Functionality 
 
 Function 
 The following parameters are defined when creating a custom field: 
ean or Enumerated) 
tion) 
 (the number of characters to be displayed) 
f the decimal point for 
he minimum value allowed) 
lowed) 
ly displays the user-defined default value) 
uired (Defines whether or not a user must enter information into this field prior to 
hen the sample is 
fine where the software should find results that are 
 Set Only, Outside 
alculation unless all values 
se As (Used to define how the field’s result is interpreted when using a Boolean or 
eld: Position, Text, Value) 
he software assigns to a custom field) 
• Name 
• Type (Integer, Real, Text, Date, Bool
• Field Type (Sample, Peak, Result, Sample Set, Component, Distribu
• Width
• Precision (the number of characters to be printed to the right o
real numbers) 
• Minimum (For keyboard-entered fields, displays t
• Maximum (For keyboard-entered fields, displays the maximum value al
• Default (Automatical
• Source (Keyboard, Calculated or External) 
• Req
acquiring the sample) 
• Formula (The user-defined mathematical calculation to take place w
processed) 
• Search Order (Used to de
references by an inter sample custom field: Result Set First, Result
First, Outside Only) 
• All or Nothing (Allows you to specify to not perform the c
referenced in the formula are found) 
• U
enumerated custom fi
• Cfield ID (The unique number that t
 Once created, custom sample identifiers appear wherever samples are listed, such as in the:
eaks, and Custom Fields views in the Project 
Sample Set information in the Alter Sample window 
ethod Editor 
ble in Review 
 Review 
• Injections, Channels, Peaks, Results, P
window 
• Samples table in Run Samples 
• Alter Sample table in the Alter Sample window 
• 
• Sample Set table in the Sample Set M
• 2D Channels table and the 3D Channels ta
• hromatogram Result table in the Results window of C
• Reports 
 Once created, Custom database results are stored in the Empower software database and 
 window of Review 
Results window 
 
appear in: 
• The Peaks table in the Results
• The Chromatogram Result table in the 
• The Results, Peaks, and Custom Fields view in the Project window
• Reports 
• Alter Sample table in the Alter Sample window 
• Component Editor in the Alter Sample window 
 Sample Set type custom fields are available. 
 Component type custom fields are available. 
 Inter sample summary type custom fields are available. 
 Boolean and enumerated fields are available. These type of fields allow you to create a 
sample type custom field that appears as a drop-down list or to create a peak or result type 
custom calculated field that assigns a user defined translation to a defined mathematical 
formula. For example, you could assign a particular criteria to the Amount field and 
specify for the Empower software to report “Pass” or ‘Fail’ for the custom field. 
 Inter-Sample calculations are available. 
 There are no limitations on the number or size of custom fields. 
 3-16 Waters Corporation 
3 er. 
 Empower Functionality 
 Custom fields may be created or modified without having to exit Empow
 The user is given the choice to create the field in just the currently selected project, or to 
access to. create it in multiple projects the user has 
 It is possible to copy custom fields between projects. 
 It is possible to calibrate on a custom field by specifying the field in the Y Value column of 
the component tab of the processing method. 
 Component references are available, CCalRef1 and CCompRef1 – 3 and Cconst1 – 7. 
 Custom fields can be nested together. For example, a custom field can i
cu
The following special 
strings: 
-60,000 translates to ND 
ncorporate another 
stom field in its formula. 
 values can be used in custom fields to translate into the associated 
-60,001 translates to N.D. 
-60,002 translates to Not Detected 
 A value of –50,000 translates to a result of zero. 
 
Login Dialog Box 
 Function 
 Login occurs to the default interface defined for each user. Multiple user interfaces (Pro, 
ickStart, Open Access, Web, System Default) are available through the Advanced >> Qu
button. 
 
Raw a ty 
terprise or 
 D ta Securi
The Waters Service provides security controlled access to raw data files in an En
Workgroup system. 
 Function 
 By default, chromatographic raw data is stored in the rawdata-drive:\ Empower\Projects 
of raw data using directory on the Empower server. However, you may change the loca
the Manage Raw Data Files capability. 
tion 
 A Windows Operating System service is available to provide security controlled access to 
raw data files in a client server system. 
 The Waters Service will be installed by the Empower installer such that it starts 
automatically when the OS starts up. 
 The Waters Service will be run using the local System account on the server and the client. 
 Read-only access is the only required access to the raw data files for all W
accounts 
indows user 
 
b e Security Data as
 Function 
 User types determine access privileges for an Empower software user. When you create a 
new user account, you grant access privileges to the new user by assigning a user type to 
that user. User types are completely customizable, and there is no limit to the number of 
user types you can create. The default user types are: Administrator (unlimited access), 
Chemist, Analyst, and Guest (read-only access). 
 A login password prevents unauthorized users from logging in to Empower software. 
You assign a login password when you create a new user account. 
 3-17 Waters Corporation 
 Empower Functionality 
3 s) prevents 
ized users from configuring or altering an acquisition server and the systems 
 The Acquisition server security scheme (via user access and privilege
unauthor
connected to it. 
 The Chromatographic system security scheme (via user access and priv
unauthorized users from modifying a system or using it acquire data. 
ileges) prevents 
 A Message Center Properties Password prevents unauthorized users from changing the 
urity log and other Message Center properties, including purging messages from the Sec
logs. 
 System Policies allow you to set rules that govern passwords, logging
software, Fu
 in to Empower 
ll Audit Trail default settings, data processing, signing off results, date 
formats, and setting up Empower software for GMP, electronic records, and electronic 
signatures 
 
 3-18 Waters Corporation 
 Empower Functionality 
3 
 
Network Support 
 
Clie
 version of the Empower Personal 
orkstation which operates on a Windows 2000 or a Windows XP platform. The Enterprise 
p also operate in a Citrix MetaFrame (thin client) environment. 
G n
nt/Server Network Support 
The Empower Enterprise system is a corporate-wide networked
w
latform can
e eral 
 Function 
 The software will support the Windows 2000 operating system on the server. 
 The application will function in an Oracle Names environment. 
 During login, if the name of a database is entered that is unknown to the application, and 
rd that database name and that name can be resolved by Oracle Names, Empower will reco
make it available for subsequent logins. 
 Contains a central password-protected database located on an Intel server. 
 Operatesin a true multi-user Client/Server environment. 
 Supports multiple computer clients running the Empower software ap
Allows computer clients to access and use data, methods,
database. 
 Permits computer clients to control and acquire data from chromatographi
Locally, through a Waters busLAC/E card or Equinox seri
c systems: 
al card installed in the 
/E32 Acquisition Server 
client computer or through the COM port of the client computer 
ugh the Waters LACOver the network, thro
 The acquisition of sample sets or trays will continue during a server shutdown or remote 
jection or sample set on network failure. Empower buffers data acquired from a single in
the acquisition computer hard disk or the Waters LAC/E32 Acquisition Server. 
 When an acquisitio
plication. 
 and results residing in the server 
n server is able to reconnect with the server, it will automatically 
upload all buffered data files and then delete the local copy. 
 Uses standard Ethernet connections. 
 Supports multiple network printers. 
 Provides full database and raw data backup and restore functions from the server. 
 Allows users to access raw data only through the Empower software application, which 
provides user-level security. 
 
 3-19 Waters Corporation 
 Empower Functionality 
3 
 
 Regulatory Compliance 
Au
ethods, results, 
ou specify Audit Trail parameters when you create a new project 
using the New Project wizard in Configuration Manager. A System Audit Trail is also available 
r activities that are not Project related. 
 
Gen
dit Trails 
Audit Trails allow you to maintain a permanent record of changes made to m
and/or samples for a project. Y
fo
eral 
 Function 
 When information is copied/backed up, the audit trail information is cop
object. 
ied along with the 
 Audit trail support is implemented for the entire system (database), sa
injections. 
mples, methods and 
 Audit trails for samples, methods and injections can be viewed separately or combined in 
the Project audit trail. 
 An Audit Trail application is provided to give access to and search capabilities for the 
System and Project Audit Trails. 
 Audit Trails can be filtered and sorted according to user defined criteria. 
 Audit Trail filtering and sorting criteria can be saved for later reuse. 
 Audit trails cannot be bypassed once activated. 
 Audit trail entries may not be deleted or modified once created. 
 Audit trails can be printed. 
 
S sty em Audit Trails 
 Function 
 Two administrative users are required to enter their passwords when purging the System 
Audit Trail. 
 Audit trails can be saved to a binary or ASCII file for archival and/or transmission. 
 Audit trails can be purged to reduce the space allocated on disk. 
 Audit trails can only be purged if two individuals with administrator level privileges enter 
ser name and passwords to allow the purge operation to complete. their u
 Unsuccessful login attempts will be audited in the System Audit Trail. 
 Account lockouts will be audited in the System Audit Trail and also brou
administrator’s at
ght to the system 
tention through the Message Center application. 
 
Project Audit Trails 
 Function 
 Project Audit Trail information can not be purged. 
 The Method audit trail is stored with the methods and moves with the methods if they are 
copied between projects. 
 The Injection audit trail is stored with the injections and moves with the injections if they 
are copied between projects. 
 The Sample audit trail is stored with the samples and moves with the samples if they are 
copied between projects. 
 Project audit trails must be activated when a project is created. 
 3-20 Waters Corporation 
3 ted. 
 Empower Functionality 
 Audit trails may not be deactivated or turned on after a Project is crea
 Project audit trails will audit the creation, modification and deletion of project objects. 
 Project audit trails can be activated without the requirement for comments to be entered 
when any objects are changed. 
 Project audit trails can be configured to require comments for Method changes, Result 
changes or Sample Information changes or any combination of these items. 
 
Sys
several aspects 
ill affect all users of 
ware ensures 
implemented easily. Selecting the 
appropriate choices configures the Empower software to comply with 21 CFR Part 11. The 
mended for electronic records compliance are also recommended for laboratories 
 
U er Policies 
T t happens when they 
lo
tem Policies 
The System Policies section of the Empower application controls the behavior of 
of Empower software. These settings are not user or project specific and w
the Empower system. By recommending configuration settings, the Empower soft
that electronic records and electronic signatures compliance is 
parameters recom
operating under GMP, GLP, GAMP, GALP, ISO 9000, or other guidelines. 
s Account
hese policies control how a user logs into the Empower application and wha
g out. 
 Function 
 The “Enforce Unique User Account Names” policy is required for electronic signature 
he current database must 
r account name 
 from the 
t you cannot reuse a 
compliance. This policy specifies that all user account names in t
be different from one another; when you create a new user account, the use
must be new. Additionally, you are not allowed to delete a user account
database; user accounts will be removed instead. (This ensures tha
username from a previous account.) 
 The “Enforce Unique User Passwords” policy is required for electro
compliance. This policy specifies that a single user account cannot reuse
in the Empower database. If your password expires
nic signature 
 an old password 
, you must enter a new password that 
you have not used before. 
 The “Passwords Expire Every n Days” policy is required for electronic 
electronic signature compliance. This policy specifies that all user accoun
expire at the end of the interval (days) you determine. When passwo
specified number of days, users receive a message
record and 
t passwords 
rds exceed the 
 requesting a password change. Users 
 are not allowed to log in again until they change their passwords.
 The “Limit # of Entry Attempts to n Tries” policy is required for electro
electronic signature compliance
nic record and 
. This policy specifies that all users have a limited number 
to the result 
t, the software denies 
ser access to Empower software and disables the user account. In this case, the 
of chances to log in successfully to the Empower database or attempts in
signoff function in Preview in Report Publisher. On the n+1 attemp
the u
system administrator must restore the account status to Active. 
 The “Enforce Minimum Password Length of n Characters” policy is req
electronic record and electronic signature compliance. This policy spec
uired for 
ifies that all user 
accounts must have passwords and that all passwords must have the minimum number of 
characters that you specify in the text box. 
 The “Don't Allow Applications to Stay Running After Logging Off” policy specifies that 
your only option is to lock all applications that are still running when you log out of 
Empower. 
 The “Don't Allow Multiple Logons” policy specifies that only one user can log in at a 
time. 
 The “Global Default User Interface” policy specifies the default user interface when the 
 3-21 Waters Corporation 
 Empower Functionality 
3 not specify Empower 
Web as the default user interface. The user’s profile overrides this default interface. 
user logs in to Empower: Pro, QuickStart, or Open Access. You can
 
New Project Policies 
T s control how the Empower audit trail facilities will be applied and enforced. hese policie
 Function 
 The “Full Audit Trail Support” policy is required for electronic record and electronic 
eature be turned on signature compliance. This policy specifies that the Full Audit Trail f
in all new projects. 
 The “Require User Comments On Method Changes”policy is required for electronic 
 must enter 
, a processing 
record and electronic signature compliance. This policy specifies that you
comments that describe any changes you make to a method (for example
method). 
 The “Require User Comments On Result Changes” policy is required for
and electronic signature compliance. This policy specifies tha
 electronic record 
t you must enter comments 
that describe any changes you make to a result in Review. 
 The “Require User Comments On Sample Information Changes” policy i
electronic record and electronic signature complianc
s required for 
e. This policy specifies that you must 
ation. enter comments that describe any changes you make to sample inform
 The “Require User Comments On Deletion” policy specifies that you m
co
ust enter 
mments that describe any deletions in Empower (e.g., delete methods, channels, sample 
sets, method sets, processing methods, instrument methods, etc.). 
 The “Don't Allow User to Change Default Full Audit Trail Support Settin
required for electronic record and electronic signature compliance. This 
g” policy is 
policy specifies 
 creating a new that the default state of Full Audit Trail Support cannot be changed when
Project. 
 The “Don't Allow User to Change Default 'Require User Commen
is required for electronic record and electronic signature compliance
ts On' Settings” policy 
. This policy specifies 
g a new Project. that the requirements for user comments cannot be changed when creatin
 The “Don’t Allow User to Copy from non-FAT Projects into FAT Pr
a user cannot copy data from a non-Full Audit Trail Project into a Fu
ojects” specifies that 
ll Audit Trail Project. 
 The “Allow the use of ApexTrack Integration” specifies that the ApexTrack integration 
nal settings 
roject level and on a processing method level. 
algorithm is enabled for the entire database. Note that there are additio
necessary to enable ApexTrack on a p
 The “Enable ApexTrack Integration” setting in the Default Settings Used When Creating 
New Projects area specifies that new projects have ApexTrack integration enabled by 
default. Note that existing projects do not have ApexTrack automatically enabled. 
Additionally, ApexTrack can be enabled/disabled through the project properties dialog 
box. 
 The “Default Integration Algorithm” setting specifies whether new processing methods 
are set to ApexTrack or to Traditional by default. 
 
 3-22 Waters Corporation 
 Empower Functionality 
3 These policies control how certain data processing and signoff functions operate. 
Other Policies 
 Function 
 The “Use v3.0X Style Peak Width and Threshold Determination” po
Empower software use the peak width and threshold determination meth
Mil
Threshold capability. This can ensure consistent integration behavio
software. 
 The “Use v2.XX Style Retention Time Calculations” policy specifies 
software uses the Millennium32 versionTransfer check box is available to allow a 2690D dissolution sa
run without needing transfe
mple set to be re-
rs. 
 A toolbar containing buttons corresponding to each of the instruments in the system is 
senting it. This allows shown with the name of the instrument and a small diagram repre
the user to switch the view to that of the selected instrument. 
 Instruments may be turned ‘On’ and ‘Off’ and also may be ‘Added’ or ‘Deleted’ within 
the editor. 
 Dual Tower gas chromatograph (HP 5890 and 6890) control is supported as well as all 
inlets and detectors supported by HP. 
 HP 7673 GC auto
 Su Heater/Cooler. 
 C Agilent 1100 Series instruments is supported via RS-232: 
tic Pump 
rnary Pumping System 
odule 
sampler control is supported 
 A plate editor is available to configure plates when using the 2790/2795 or other 
autosamplers. Samples can also be easily loaded into the sample loading table using this 
editor. 
 The Waters Alliance Dissolution System (2690D) control is supported. 
 The 474 Fluorescence detector control is supported. 
 The Waters Capillary LC control is supported. 
 The SAT/IN, 474 and HP 5890 and HP 7673 support is available through a serial card 
port or a PC COM port. 
 3-24 Waters Corporation 
 Empower Functionality 
3 ntation is supported and described in the 
Empower System Installation and Configuration Guide. 
 The control of any current Waters’ instrume
 
 
Res
privilege by the 
istrator can review results in Preview and then sign off the displayed results. 
Empower software allows two levels of result sign off. Multiple signoffs on the same result are 
a review. 
 
ult Sign Off 
An electronic signature process in which personnel who are assigned sign-off 
system admin
llowed in P
 Function 
 When a result is signed off, the report used for sign off is saved as a PDF file and stored in 
f” system policy the database, provided that the Save Report Image (as PDF) after Sign Of
is enabled. 
 Reports saved as a PDF after signoff can be retrieved at a later time to
as it was when it was signed off using the Report Viewe
 see the data exactly 
r. 
 An “Allow this Method to be used in Sign Off” check box is present to specify whether or 
not any given report can be used for sign off. 
 Two levels of results sign off are available (“Sign Off 1” and “Sign Off 2”) to allow 
ries or levels of sign off privilege within the software. different catego
Multiple signoffs are allowed wi
If the “Enforce Sign Off 1 Befo
publisher does not allo
been perform
Each sign off include
The date and time
The full, printed na
The reason of the sign off 
T
The sign off method date 
DThe sign off method I
The sign off Method name 
The sign off method version 
 All of the pages of the current report must have been previewed before a
performed. 
 sign off can be 
 Sign off can be done on individual results or on groups of results, depending on the type 
of report used to preview the results. 
 Sign off inactivity delay is enforced. 
 The first sign off during a session requires that two unique pieces of information be 
entered to identify the user (user name and password). 
 Subsequent sign off’s during the same session require only a single piece of identification 
to be entered (password). 
 A user can sign off results while one or more differe
 thin each sign off level. 
 re Sign Off 2” system policy is enabled, the report 
w a sign off 2 until a sign off 1 with a valid sign off reason has 
ed. 
 s: 
 the signoff occurred 
me of the signer 
he sign off ID 
 
nt users are logged into the 
application to perform other functions such as data acquisition or processing. 
 All review and approval is performed within the Empower application, with complete 
tracking of approval state. 
 The number of signings for each result will be stored with the result. 
 When determining the reason for an electronic sign off, the user can type in a reason, or 
choose from a list of predefined reasons. 
 When a result has been signed-off using “Sign Off Level 2”, the result may be locked to 
prevent further results being saved based on the specified sample. 
 3-25 Waters Corporation 
 Empower Functionality 
3 Pro Interface 
 
power software. This interface is similar to that 
m32 and will therefore be familiar to Millennium32 users. 
The Pro Interface provides access to all features of the Em
of Millenniu
Pro Window 
G n tionality e eral Func
 
 Function 
 All activities in Empower are initiated from the Pro Window when using the Pro interface. 
 The Pro window works like a web page, not a classic windows application. For example, 
ing. the user single clicks a button to activate it rather than double click
 The About Box reports the following editable user information: Lic
Company Name, and Total Assurance Pla
ensed User Name, 
n ID. 
 The About Box reports the following system information: the build number of the 
stalled options. software, the installed service packs, and the in
 The Pro Window is dockable with an Always on Top and an Autohide se
docke
tting. The 
d state is stored for each operating system user. 
 All activities initiated in the software are assigned to the currently logged in user. 
 Multiple Empower applications may be run simultaneously. 
 During login, if more than one database is available, the user may choose which database 
to log into. 
 When logging out of Empower, the user will have the option to close any open Empower 
r lock them and leave them running. applications, o
Locked applications
is done by the 
The Login Win
Empower: 
Running Samples 
Processing Data 
Printing Rep
Browsing Projects 
Configuration and System Administration 
 The software will allow multiple people to independently log in to a single workstation or 
client. 
 Multiple logins to a single workstation or client may b
 may be unlocked by the user who originally locked them. Unlocking 
user logging into Empower again. 
 dow provides simple access to the most commonly used functionality in 
Reviewing Information 
orts 
e disabled. 
 Multiple logins on a single client or workstation will use a single connection to an 
individual database. 
 Multiple logins on a single client may be done to different databases. 
 Empower allows a default database to be defined such that the user does not have to 
specify a database during login. 
 After clicking the Run Samples button, a Use QuickStart button is located in the Run 
Samples dialog to allow the user to start the QuickStart interface. 
 
 
 
 3-26 Waters Corporation 
 Empower Functionality 
3 Project Window 
nd processed) 
d view filters. The Project Window provides the main access to projects and their 
 
General Functionality 
A project is the object that holds all Empower information such as data (raw a
methods an
associated data. 
 
 
 A Method Difference utility is present in order for a user to easily 
d over time
 
determine what changes have been made to a metho . 
 In a Full Audit Trail Project, a comment is required 
data or methods. 
for deletion of 
 Ability to deep copy/paste or shallow copy/paste i
projects, depen
nformation in 
ding on system policy and user privilege. (deep = 
o audit trail
 to
all audit trail information is maintained, shallow = n
information) 
 
 Project Audit Trail information is available. The Proj
Trail cannot be purged 
ect Audit 
 Empower allows copying of results, result sets and 
from one project to another and to/from the Window
All mechanisms which support copying Empower obj
+ drop, the Copy To Project menu ite
custom fields 
s file system. 
ects, like drag 
m, etc. will be extended to be 
 
enabled in the Result, Result Set and Custom Fields. 
 A user has the ability to lock a channel and then, no more results 
be unlocke
ilege to lock a channel and 
 
may be saved which reference it. Channels can later 
The user must have ‘Lock Channel’ priv
d. 
‘Unlock Channel’ privilege to unlocka channel. 
 The quantitate only button is present in the Processing dialog. This 
 should be 
ration information. 
 
notifies the background processing that quantitation
performed using existing integration and calib
 Multi-Project mode allows the user to use a single pro
to view data from multiple projects simultaneously. 
ject wind √ ow
 The Cancel Fetching message box provides a mechanism to stop 
fetching data when updating a view. 
 Empower allows copying of sample sets, injections and channels 
ices. 
 
from one project to another and to/from external dev
 View As menu items are available. For example, to ‘View’ sample 
s or to ‘View 
rail information and 
 
sets ‘As’ injections, to ‘View’ results ‘As’ sign off
samples ‘As’ results. You can also view audit t
instrument method information using this capability. 
’
 Dragging and dropping and copying and pasting is a
 Function Functionality 
Not Present in 
QuickStart 
vailable to 
copy items between projects and to/from the Windows file system. 
 
 The project window can appear in ‘Data Selection Mode’ if 
accessed via the Process Data, Review Data, or Print Data buttons 
located in the Pro Window. This mode is a convenience feature. 
√ 
 Project Audit Trails can be enabled. This functionality specifies 
whether or not users are required to describe changes to any 
method, method set, sample, template, result, or calibration. It also 
determines whether or not the Alter Sample history is generated 
and whether or not to retain all versions of all methods in the 
 
 3-27 Waters Corporation 
3 
 Empower Functionality 
database. 
 Method History (part of the Audit Trail functionality) as available 
in the Project Window. 
 Any altered record is automatically flagged with a ch
the altered field. 
eck mark in
 All method and result changes may be determined 
version number of the method or result, respectively. 
by viewing t he 
 Methods may be locked to prevent modification. Once locked, a 
be created us g 
 method. 
 
method cannot be unlocked but a new version can 
a new method name to differentiate it from the locked
in
 The user can acquire data, create methods, process dat
results, generate reports, and manage information us
views, and tools from the Project window. 
a, review 
ing the menus, 
 
 Double-clicking on an item(s) in the view table exp
a corresponding view. For example, double-clicking 
ands that item to 
on a sample 
n Injection view
uble-clicking an injection will display corresponding channel 
hannel view. Double-clicking a result set will display 
ding result items in the Result view. 
 
set will display corresponding injection items i
Do
. 
items in C
correspon
The f
window
Instr
Processing 
Report 
Export 
Sample Set 
Sample Set Method Template 
Meth
 ollowing types of methods are available in the project 
: 
ument 
od Set 
 
 Instrument methods are specific to the specific system 
configuration, but may be used with all systems of identical 
component configuration. 
 
 All changes are automatically tracked within the embedded Oracle 
database. 
 
 
 3-28 Waters Corporation 
 Empower Functionality 
3 Views
The View Table displays information that corresponds to the selected view and view filter. 
 
 
 
 Function Functionality 
The following views are available and allow the
specific information st
 examine 
uring Sample Sets - A set of samples grouped togethe
sample loading and acquisition 
Injections - Unprocessed raw data, includes all cha
a single injection 
Channels - Individual raw data channels 
Methods - Instrument, processing, report, export
method sets and sample set method templates 
Result Sets - Set of results gene
set 
Results - Processed raw data generated from
Peaks (version 3.2) - Peaks (compounds, PD
peaks, GPC/V peaks, System Suitability peaks) 
Sign Offs - Displays all data that has been si
contain the following fields: 
(username), Signoff Reason, Signoff Date, Signoff
Method ID, Signoff Method Nam
Signoff Method Version. 
es - Calibration curvCurv
GPC/V molecular weight distributions 
View Filters – displays as view filters prese
and allows them to be 
Not Present in 
QuickStart 
 user to
ored in the Empower database. 
r d
nnels from 
, sample set. 
rated from a processed sample 
 a channel of data
A peaks, GPC 
gned off. May 
 Result ID, Signoff Full Name 
 ID, Signoff 
e, Signoff Method Date, and 
es for LC, IC, GC, GPC/V, and 
nt in the project 
deleted if necessary. 
Custom Fields (version 3.2) - All custom fields (created for 
each project in Configuration Manager) 
Audit Trails – Displays audit trail entries for project 
il on. 
View Filters and 
Custom Fields 
views are not 
available in the 
QuickStart 
Interface 
information. May contain the following fields: Date, User, Action, 
and Details for each change This view is displayed only if the 
project has Full Audit Tra
 
View F
 
 limit or tailor the types of information displayed reating and 
applying different view filters, you determine what informatio iew table as well 
 
uickStart, new view filters cannot 
 
ilters 
View filters by the view. By c
n appears in the v
as the sorting order of this information. 
Note: Although existing view filters can be used in Q
be created. 
 Function Functionality 
Not Present in 
QuickStart 
 Wildcards (% and ?) can be used with criteria set in a view filter. √ 
 
 When saving a view filter, it can be defined which software 
interface the view filter is useable in. 
√ 
 3-29 Waters Corporation 
 Empower Functionality 
3 ny Empower 
ser) or Private (available only to the user that created the view 
√ View filters can be designated as Public (available to a
u
filter). 
 Default view filters are available to aid new users. 
 Just-In-Time view filters are temporary view filters wh
user to enter variable information to complete them b
executed. The user specifies which fields the use
prompted for by using a special syntax in the vi
ich allow the 
efore they are 
r should be 
ew filter editor. The 
gger the pr 
indow to prompt the user to enter conditions for that field. 
 
‘#’ character in a field condition is used to tri
w
oject
 A View Filter Wizard is available for assistance in cre
filters. 
ating view √ 
 
 The ‘Group By’ functionality allows you to create a vi
will sort out rows according to the maximum or
speci
ew filter that 
 minimum values of 
fied columns. This feature, for example, allows you to create 
result for each 
as been 
 
a view that displays only the most recently processed 
channel, regardless of how many times the channel h
processed. 
 The ‘Create a Condition’ functionality provides guidance as to how 
he view filter. 
√ 
to specify a condition for a particular column in t
 Click
an
ing the Update button to the right of the Filter By drop-down 
view filter d 
displays the most current available data. 
 
list rescans the Empower database using the current 
 The view filter table allows for AND-ing and OR-ing column 
conditions. 
 
 When using the View As capability, the view filter that was last 
current in the destination view is used to display the selected data. 
 
 
Tool
 
 The Toolbar displays shortcut buttons that provide quick access y commands used in 
 
s 
 to the primar
the Project window. 
 Function 
 The following tools are available to allow the user to perform 
base: 
a processing 
mpare calibration 
selected in the 
romatograms 
oject window Channels view. 
og box, where 
you select the report method to be used to print your information. 
After you select the report method and click OK, the Report 
Publisher Preview window appears with the selected information 
displayed exactly as it appears when printed (using the selected 
report method). You can preview data, method or method set 
contents, calibration curves, and so on. Reports can be interactively 
modified as necessary. 
Process- Displays the Background Processing and Reporting 
dialog box, used to batch process samples, print reports, and export 
Compare and 
Projects Available 
tools not available 
in QuickStart 
Interface 
various operations on data stored in the Empower data
Review - Displays Review, where you perform dat
and analysis of acquired data. 
Compare - Displays Compare , where you co
curves or GPC/V molecular weight distributions 
Project window Curves view, or where you overlay ch
selected in the Pr
Preview - Displays the Open Report Method dial
Functionality 
Not Present in 
QuickStart 
 3-30 Waters Corporation 
 Empower Functionality 
3 d Reporting 
cted in the 
channels, results, 
ethods, and 
d Reporting 
g box, used to background export data selected in the view 
ls, results, and 
dow, where you 
er-entered data associated with a sample or sample 
onent Amounts, 
roject mode, 
ovides full 
and allows for 
tion, and 
yed out if you do 
ples.
ilable dialog 
jects to the Project tree, 
oject in the 
roject mode .
r example, an 
ipboard into the 
Help - Enables context-sensitive Help for the window. When 
you click the tool, then subsequently click an area or item in the 
window, a popup explanation of the area or item appears. To 
reactivate the tool and close the popup, click the tool again. To 
close the popup only, click the popup or anywhere in the window 
except the Help tool. 
data during processing. 
Print - Displays the Background Processing an
dialog box, used to print reports based on the data sele
view table. You can print sample sets, injections, 
result sets, peaks, curves, method sets, processing m
instrument methods. 
Export - Displays the Background Processing an
dialo
table. You can export sample sets, injections, channe
result sets. 
Alter Sample - Displays the Alter Sample win
can modify us
set such as Sample Name, Sample Type and Comp
etc. Alter Sample is grayed out when in the Multi-P
Global Projects view. 
Run Samples - Displays Run Samples, which pr
control over chromatographic system instruments, 
baseline monitoring, sample loading, data collec
interactive methods development. This tool is gra
not have any privileges that allow you access to Run Sam
Projects Available - Displays the Projects Ava
, where you can add available probox
remove projects from the Project tree, or update a pr
Project tree. This button is active only in the Multi-P
Copy - Copies selected view table contents (fo
instrument method) to the Windows Clipboard. 
Paste - Pastes the contents of the Windows cl
current project. 
 
 3-31 Waters Corporation 
 Empower Functionality 
3 Alter Sample 
 
annels, or injections. 
ange sample identifiers, and enter 
amounts and custom field information after acquisition. 
 
From the Alter Sample window you can modify acquired sample sets, ch
You can correct errors made while loading samples, ch
component 
 Function 
 If injection lines of a sample set do not contain any injections, they will get highlighted in 
the rest of the the Alter Sample editor. Those highlighted lines will be uneditable while 
lines remain editable. 
 View As menu items are available in the Alter sample editor. Select sample lines from the 
item from the right mouse context menu. The Project 
ata or results if the request is met. 
requests (menu items). 
table and select a View As menu 
Window will display d
 
There are four types of 
View As Sample Sets 
View As Injections 
View As Channels 
View As Results 
 Dissolution capabilities (Bath, Vessel, and Draw Time columns) are available in the table. 
 In the Alter Sample window, you have the ability to ‘Copy Components’ from a 
processing method or a method set. 
 Samples can be given ‘Labels’ in Alter Sample. Labels can be used during processing and 
printing to perform bracketing. They can also be used with Derived Channels and custom 
lds. fie
 The ‘Autofill’ functionality is available in Alter Sample. 
 Sample History (part of the audit trail functionality) can be seen in Alter Sample. 
 
 
Import / Export 
d in the w export Note: Although existing export methods can be use
m not be created. 
QuickStart interface, ne
ethods can
Function 
Data 
AIA (A
ExpertEase (860) 
ASTRA text data 
PD ASCII data 
MassLynx 
 Data can be exported from Empower in the following formats:
PDF (processed data only) 
EMF (processed data only) 
OpenLynx 
 
 ASCII 
AIA (ANDI) 
 Functionality 
Not Present in 
QuickStart 
 can be imported into Empower in the following formats: 
NDI) 
 
 
 
 Importing and exporting ASCII PDA spectra is supported. 
 Any file that may be generated via exporting may also be emailed. 
 Multiple page reports are exported as a single file. 
 You can specify to export/email fields and report tables via the 
export method in ASCII format. 
√ 
 
 3-32 Waters Corporation 
 Empower Functionality 
3 Run Samples 
n Samples Window is where data acquisition and instrument control takes place. Use Run 
 
ges to the instrument 
s of data (wavelength or spectra). 
• Load samples (single sample or sample set). 
ngle injection or a sample set. 
dow are: 
 single injection 
d by clicking the Single tab). 
 an instrument 
e the methods in 
aded in Run 
 and their 
 (function, vial number, injection volume, method set, and so 
s currently running 
 Sets tab). The currently 
(accessed by 
 copy of the 
d. This table 
thod. 
s the data is 
A channel, and so on. 
strument Control panes that display the current instrument method, solvent delivery 
mits), 
low, Stop Flow, 
 ( current sample 
nd after data 
 Box that displays a list that lets you view or change the run 
mode of the currently running sample set method, or set the run mode when acquiring a single 
injection. Run modes are: Run Only, Run and Process, and Run and Report. 
• The Interactive System Suitability Drop-Down List Box that displays a list that lets you 
view or change the interactive system suitability mode for the currently running sample set 
method, or set the interactive system suitability mode when acquiring a single injection. 
System Suitability options are: Continue on Fault, Stop on Fault, Next Sample on Fault, Next 
Sample Set on Fault, and Reinject on Fault. 
The Ru
Samples to: 
• Control instruments, change instrument parameters, and save chan
method. 
• Monitor the baseline and look at Real-Time plot
• Acquire data from either a si
 
The main components of this win
 
• The Single Inject page that provides parameters and controls for acquiring a
(accesse
• The Develop Methods button launches a wizard that allows you to develop
method, edit an existing processing method, define derived channels, and sav
a method set. 
• The Samples table that displays an editable, ordered list of samples currently lo
Samples (accessed by clicking the Samples tab). When saved, the samples
associated operating information
on) comprise a sample set method. 
• The Sample Sets table that displays an ordered list of sample set method
or queued to run in Run Samples (accessed by clicking the Sample
running sample set method appears in red. 
• The Running table that displays the currently running sample set method 
clicking the Running tab). When this table is displayed, it appears as an exact
Samples table. Rows that have been run or are in process are displayed in re
allows you to interrupt acquisition so that you can modify the sample set me
• The Monitor panes that display up to four real-time plots of channel data a
acquired. Allows you to overlay 2D chromatograms, customize a PD
• The In
parameters (flow rate, gradient percentages, current pressure, and pressure li
temperature parameters and manual instrument controls such as the Change F
Monitor and Setup buttons 
• The Status bar that displays current status codes and injection information
set, current vial, current injection and current run time) before, during, a
acquisition. 
• The Run Mode Drop-Down List
 3-33 Waters... ...................... 27 
... ...................... 27 
... ...................... 
... 
... ...................... 
... ...................... 
... ...................... 
... 
... ...................... 
... ...................... 34 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
Review Main Window Toolbar ............................................................................................................. 41 
Processing Method Window ................................................................................................................. 43 
Results Window .................................................................................................................................... 
Calibration Curve Window................................................................................................................... 
Method Set Editor................................................................................................................................. 
PDA/MS Functionality ......................................................................................................................... 
Report Publisher..................................................................................................................................... 47 
General Functionality .......................................................................................................................... 47 
Chromatogram and other Plot Groups................................................................................................. 49 
..
User Groups ............................................................................................................... .. ..
User Types...................................................................................................................... .. 6
Acquisition Servers..................................................................................................... .. .. 6
Systems ....................................................................................................................... .. .. 7
Default Strings........................................................................................................... .. .. 9
..
Privileges................................................................................................................... ..
Message Center............................................................................................................
System Monitor............................................................................................................ .. 14
Installation ................................................................................................................... .. 14
Custom Fields ......................................................................................................................................... 15
Login Dialog Box ......................................................................................................... .. 17
Raw Data Security....................................................................................................... .. 17
Database Security ........................................................................................................ .. 17
Client/Server Network Support ................................................................................. ..
General...................................................................................................................... ..
20Audit Trails .................................................................................................................. ..
20General...................................................................................................................... ..
20System Audit Trails.................................................................................................... ..
20Project Audit Trails ...................................................................................................
21
..
.
21
System Policies .. .......................................................................................................... ..
User Account Policies ............................................................................................... ..
24
New Project Policies ................................................................................................. ..
24
Other Policies............................................................................................................ ..
25
Instrument Control ..................................................................................................... ..
26
General Functionality ...............................................................................................
26
..
26
Result Sign Off............................................................................................................. ..
Pro Interface ...................................................................................................... ..
29
Pro Window ............................................................................................................................................
29
General Functionality ............................................................................................... ..
30
Project Window ........................................................................................................... ..
32
General Functionality ...............................................................................................
32
..
Views .........................................................................................................................
33
..
34
View Filters ............................................................................................................... ........................
35
Tools .......................................................................................................................... ..
36
Alter Sample .............................................................................................................. ..
36
Import / Export .......................................................................................................... ..
38
Run Samples ................................................................................................................ ........................
38
General Functionality ...............................................................................................
39
..
.
39
Run Samples Toolbar ............................................................................................... ..
Sample Loading Table ............................................................................................... ..
45
Processing..................................................................................................................... ..
45
General Functionality ............................................................................................... ..
46
Derived Channels.........................................................................................................
46
..
General Functionality ............................................................................................... ..
.Review Window .......................................................................................................... ..
General Functionality ............................................................................................... ..
Table Groups............................................................................................................. .. 50... ...................... 
... ...................... 
... ...................... 51 
... ......................Corporation 
 Empower Functionality 
3 General Functionality 
 
 
 Function 
 When data is acquired, the database version and the software build number used for 
ation. This information is blank for data acquisition is stored with the channel inform
acquired using Millennium32 Software. 
 Ability to acquire an RF Internal Standard type sample. 
 No printer is required unless the run mode is Run and Report. 
 Detail is provided for instrument errors to indicate the instrument where the failure has 
occurred (sometimes this is not possible). 
 Prep Inject functions (Inject Immediate Standards, Inject Immediate Samples) are added 
olumn. to allow a large volume sample to be manually loaded onto the c
 A sample set shutdown method can be (optionally) specified in the Run 
d
Sample Set 
ialog. 
 A plate editor is available to configure plates when using the 2790/2795 o
autosample
r other 
rs. Samples can also be easily loaded into the sample loading table using this 
editor. 
automatically create sample sets with or with
in these wizards.) 
 The user has the ability to ‘Re-Inject Samples’ or to ‘Finish an Interrupted Sample Set.’ 
 The user has the ability to ‘Alter a Running Sample Set.’ 
 Data that is currently being acquired can be brought into the Review Window
processing and manipulation.
 A Sample Set Method Wizard and a Sample Set Method Template Wizard are available to 
out bracketing. (The Plate Editor is available 
 for 
 
 Component Amounts can be entered in the Run Sample window. 
 The user has the ability to abort acquisition at any time deemed necessary. 
 The real-time plot displayed in the Run Samples window can be customized in various 
nd whether or not ways. For example, the user has control over the x- and y-axis scaling a
to overlay or even display the plots. 
 
 
R n 
 
T buttons that provide quick access to frequently used commands in 
Run ples (for example, 
to th
 
u Samples Toolbar 
his toolbar displays shortcut
Samples. You can drag the toolbar (dock) to another location in Run Sam
e right edge of the window) or anywhere on the Windows desktop. 
Function 
The following tools are available: 
Load - Displays the Load Samples dialog box , which contains opti
samples into the Samples table. 
Wizard - Creates a new sample set method using the Sample Set
Save - Displays the Sav
 
 
ons for loading 
 Method Wizard .
e Current Sample Set dialog box , which allows you to name 
and save the sample set. 
Run - Displays the Run Sample Set dialog box , which allows you to run the selected 
sample set. 
Abort - Displays the Abort Options dialog box , which contains options for 
terminating data acquisition. This button stops acquisition, but does not stop pump flow.
Plates - Displays the Define Plates for Sample Set Method dialog box , where you set 
up plate type and position, and define vial/well injection locations for your sample set 
method (for systems that use plates). 
 3-34 Waters Corporation 
 Empower Functionality 
3 - Displays the Component Editor , which allows you to enter component 
s you to create a processing method with the 
py -Copies the selection and puts it on the Windows Clipboard. 
oint designated by 
u click the tool 
planation of the area or 
rs. To reactivate the tool and close the popup, click the tool again. To close 
the popup only, click the popup or anywhere in the window except the Help tool. 
Amounts
data for each sample. 
Review - Starts Review , which allow
currently acquired data and to view processed results. 
Cut - Cuts the selection and puts it on the Windows Clipboard. 
Co
Paste - Pastes the Windows Clipboard contents to the insertion p
the cursor. 
Help - Enables context-sensitive Help for Run Samples. When yo
then subsequently click an area or item in the window, a popup ex
item appea
 
S m
 
a ple Loading Table 
Fu
e following columns are present in the Sample Loading Table to control sa
parameters. Some columns are self-explanatory, the others are desc
Vial 
SampleName 
Label - Use this column to mark (label) each Inject function row in t
on which you want Empower 
mple acquisition 
ribed. 
he Samples table 
software to perform a Calibrate, Quantitate, or Report 
at contain a particular 
 the Label Reference 
 Report 
r Report function on all 
n to be 
, Inject 
rds, Inject Immediate 
uilibrate, 
 Fields. 
g - Use this column to control processing and system suitability actions for 
m Suitability 
s in this column 
o Sys Suit. 
t/Report Method - Use this column to specify either the method set to be 
 associated function or the report method to be used with the associated 
ion. 
, or Report 
 of preceding Inject 
Quantitate, or Report 
t function rows previously acquired that contain the matching label 
Run Time or Dissolution Wait Time (minutes) 
Data Start (minutes) - Use this column to specify the time that data collection is to 
begin, as measured from injection time. Data Start allows you to delay start of data 
acquisition to control the size of the datafile. Data Start is also useful for eliminating 
eluent fronts from the datafile. 
Next Inj Delay (minutes) - Use this column to add a delay between the end of data 
acquisition for an injection and the start of setup for the next injection. Run time is the 
time from injection until the system stops acquiring data (and Next Inj. Delay begins).
function. When Empowers software runs Inject function row(s) th
label in their Label column and then encounters a matching label in
column of a subsequent row (one that contains a Calibrate, Quantitate, or
function), Empower software performs the Calibrate, Quantitate, o
preceding rows with the matching label. 
Function - Use this column in the Samples table to specify the functio
performed by each row in the Samples table. Available functions include
Standards, Inject Samples, Inject Controls, Inject RF Internal Standa
Standards, Inject Immediate Samples, Purge Injector, Purge Detector, Eq
Condition Column, Calibrate, Quantitate, Report, Summarize Custom
Processin
rows in the Samples table (by overriding the Run Mode and Interactive Syste
selections in Run Samples). The processing and system suitability option
are: Don’t Process or Report, Don’t Report, Normal, Ignore Faults and N
Method Se
used with the
Report funct
Label Reference - Use this column to mark a Calibrate, Quantitate
function row with a label that matches the label in the Label column
function rows. Empower software performs the specified Calibrate, 
function on those injec
in their label column. 
# of Injections 
Inj Vol (µl) 
 nction 
 
 3-35 Waters Corporation 
 Empower Functionality 
3 ctor by which the 
ntration of each 
 X value read 
ple Weight value to 
e software 
andard 
mpower software multiplies the X value read from the 
to calculate amounts 
Level - Use this column to identify all standards in the table that are to have their 
can be averaged 
n the processing 
lection Valve) - Use this 
n Selection Valve 
 2690D. 
 the Auto 
 2690, 2690D, and 2790 Separations Modules. Auto 
 vials, one of 
 
 the dissolution 
lution bath from 
Transfer Time (Dissolution) - This column indicates the time to transfer (or draw) a 
dissolution sample from the bath to the autosampler for injection. The Transfer Time 
field is not editable in the Samples table. You specify the information for this field in the 
r B Transfer page of the New Sample Set Method wizard or in the Bath A or B 
operty tab of the Dissolution dialog box. 
SampleWeight - Use this column to specify the sample weight fa
software (during calibration) multiplies the calculated amount or conce
standard component. During quantitation, Empower software divides the
from the calibration curve (of the standard components) by the Sam
calculate amounts and concentrations for each unknown sample. 
Dilution - Use this column to specify the dilution factor by which th
(during calibration) divides the calculatedamount or concentration of each st
component. During quantitation, E
calibration curve (of the standard components) by the Dilution value 
and concentrations for each unknown sample. 
amounts averaged together. All vials identified with the same level label 
together to create a single data point in the calibration curve, if specified i
method. 
Column Position (2790 and 2690D with optional Column Se
column to specify the column flow direction through an optional Colum
in a Waters 2790 or
Auto Additions (2690, 2690D, 2790) - Use this column to perform
Additions function with the Waters
Additions makes an injection that is composed of sample from up to ten
which is the sample vial. 
Bath (Dissolution) - Use this column to specify the bath (A or B) in
system from which an injection is to be made. 
Vessel (Dissolution) - This column indicates the vessel in the disso
which a sample is to be transferred. 
Bath A o
Transfer pr
 
Proc s
Gene
 
es ing 
ral Functionality 
 Function 
 Data can be processed using the Traditional integration algorithm (w
Millennium32 Software) or the ApexTrack algorithm which is new in Em
The primary goals of ApexTrack integration are to provide an integratio
ng baselines, to
hich was used in 
power Software. 
n package that 
 eliminate the need for 
on method. 
integrates large and small peaks in noisy or slopi
manual integration, and to reduce the time needed to develop an integrati
 Ability to use a Cross Channel Internal Standard (an internal standard
different channel than the peaks of interest). 
 peak from a 
 The following information regarding the Empower software is stored wi
during processing: Integration
th the result 
 Algorithm (Traditional or ApexTrack), Software Version, 
Build Number, Integration System Policies (Use v3.0X Style Peak Width and Threshold 
Determination and/or Use v2.XX Style Retention Time Calculations, or Blank. 
 A Calibrate Only choice is available in the Processing Dialog. 
 Processing of an RF Internal Standard is available: the internal standard peak(s), which is 
calibrated, is in the same chromatogram as the unknown peak(s), which is quantitated. 
The RF internal standard is used as either a curve reference or a default peak. 
 Processing codes display informational and/or warning codes that the Empower software 
encountered while processing the result. 
 3-36 Waters Corporation 
 Empower Functionality 
3 t to determine 
rabolic fit through the five highest points to determine the 
 Peak retention times can be either by using the highest physical data poin
the peak apex, or by using a pa
peak apex. (Traditional integration only) 
 Algorithms used during peak integration and processing are publish
and Processing The
ed in the Acquisition 
ory Guide, along with the Empower Help files. 
 If a peak is not found, the peak type field is set to missing, and an error f
configured to alert the user. 
lag may be 
 Peak grouping is allowed within Empower based on either a time range or a named group 
ted as if it were a single of peaks. A peak group may be given a name and may then be trea
peak for the purposes of quantitation. 
 Peak names are assigned based on retention time. A peak must fall within a preset 
o select the 
 second, third, fourth, 
window around an expected retention time. The system may be refined t
closest, greatest area, least area, greatest height, least height, first,
fifth, closest negative, or last peak within the window. 
 Peak integration is based on two global parameters: Peak Width and Threshold. These 
tegration. parameters may be used in conjunction with timed events to optimize in
 Minimum peak areas may be set in the integration method, and they may
different regions in the chromatogram by using timed events 
 be varied for 
 Minimum peak heights may be set in the integration method, and they may be varied for 
 events. different regions in the chromatogram by using timed
Various timed even
can set start tim
modified graphically
Timed events a
Allow Negative Pea
Inhibit Integration 
Force Baseline by T
Force Baseline by P
Valley-to-Valley 
Forward H
Forward H
Reverse Horiz
Reverse Ho
Force 
Force Pe
Tangential Skim 
Exponential S
Set Minim
Set Min
Set Liftoff 
Set Pe
Set Touchdo
Timed events ava
Allow Negati
Detect Sho
 ts may be configured multiple times within a chromatogram. The user 
es, and stop times if appropriate, for the timed event, which can then be 
. 
 vailable when using Traditional integration include: 
ks 
ime 
eak 
orizontal by Peak 
orizontal by Time 
ontal by Peak 
rizontal by Time 
Drop Line 
ak 
kim 
um Height 
imum Area 
ak Width 
wn 
 ilable when using ApexTrack integration include: 
ve Peaks 
ulders 
Gaussian Skim 
Inhibit Integration 
Set Detection Threshold 
Set Liftoff % 
Set Minimum Area 
Set Minimum Height 
Set Peak Width (sec) 
Set Touchdown % 
Valley-to-Valley 
 3-37 Waters Corporation 
 Empower Functionality 
3 e types available include: 
pline 
int to Point 
ear 
adratic 
Cubic 
 Thru 0 
tic Thru 0 
hru 0 
hru 0 
u 0 
Inverse Linear 
Log-Log Linear 
Response Factor 
Calibration curv
Cubic s
Po
Lin
Qu
Fourth 
Fifth 
Linear
Quadra
Cubic T
Fourth T
Fifth Thr
 
ved Channels 
A method set supports the creation of deri
Deri
ved channels. A derived channel is a data channel that 
e selective or 
e formula for creating a derived 
rty tabs in the Derived 
 Channel uses include: 
ine Subtraction – Subtracts a (blank) gradient baseline from a 2D chromatogram when 
(for example, 
 or fourth) to a data 
P2+B)] to two data 
er of data points, 
elength. 
 chromatogram at a single mass. 
ta point is 
al Plot (PDA and MS options) – Averages the absorbance values of a specific range of 
wavelengths (PDA) or sums the intensities of a specific range of masses (MS). 
PDA and MS options) – For PDA, divides the absorbance value at one wavelength 
by the absorbance value at another wavelength (PDA). For MS, divides the intensity value at 
 the intensity value at another mass. 
atograms from a PDA channel based on a table of 
starting times and corresponding wavelengths. 
• Total Ion Chromatogram (MS option) – Extracts a Total Ion Chromatogram (TIC) from a data 
channel. 
 
General Functionality 
 
is created, or derived, from acquired raw data. It is generated by applying som
mathematical operation to the channel data. You define th
channel from an acquired data channel (or channels) using the three prope
Channels dialog box. Derived
 
• Basel 
absorbance artifacts, such as solvent UV absorbance, are significant. 
• Ratios – Divides the data from one channel by those of a second channel 
Channel A divided by Channel B). 
• Derivatives – Applies a mathematical derivative (first, second, third,
channel. 
• Blending – Applies an operator [+, –, *, ¸, or (P1+2K*P2+B)/(P1–2K*
channels (chromatograms) to combine them into a single chromatogram. 
• Smoothing – Applies Savitsky-Golay filtering to average a defined numb
thereby decreasing noise in the data channel. 
• Single Wavelength (PDA option) – Extracts a chromatogram at a single wav
• Single Mass (MS option) – Extracts a
• Max Plot (PDA and MS options) – Creates a chromatogram in which each da
plotted at its maximum absorbance (PDA) or maximum intensity (MS). 
• Tot
• Ratio Plot (
one mass by
• Timed Wavelength (PDA) – Extracts chrom
 Function 
 There are three property pages for a derive channel: 
 3-38 Waters Corporation 
3 l) 
constant (optional)
 scaling (all optional) 
 Empower Functionality 
First Channel – to define a raw data channel and a constant (optiona
Second Channel – to define an operator, a raw data channel and a 
Filter/Offset – to define smoothing, derivative, RT offset, RT
 A ‘Time Program’ derived channel can be created to extract PDA from different 
wavelengths at various times. 
 PDA channels can be extracted on the Second Channel tab. 
 A ‘Chromatogram Time Adjustment’ functionality is available toadjust the overall 
retention time offset and retention time stretch that can occur when samples are collected 
on different systems. 
 
Rev
ract with 
during data 
acquisition), or from Compare. The data can be unprocessed data (sample sets, injections, 
elop your processing 
a, and review 
hannels table 
cted data channel 
in the 2D Channels table displayed as a chromatogram in the Chromatogram plot. A Data tree 
jections, or result sets are brought into Review. You use 
this tree to access the individual samples, injections or results in the set. The table tabs allow you 
lay of 2D channel data and 3D channel data (PDA or MS option only), 
sed data in the Peaks table. 
ing daughter windows: 
ethod Window 
• ow 
• ion Curve Window 
• Method Set Editor 
 
General Fu
 
iew Window 
The Review Window is an Empower application that allows you to view and inte
chromatographic data brought in from the Project window, from Run Samples (
channels) or processed data (result sets, results). From Review, you can dev
method (using a wizard or interactively), process data, review calibration curve dat
processed results. 
All data items displayed in Review are listed in the 2D Channels table and 3D C
(PDA or MS data only) at the bottom of the Review Main window, with the sele
appears in Review when sample sets, in
to switch between the disp
or view proces
Review contains the follow
• Processing M
 Result Wind
 Calibrat
nctionality 
unction 
 An option dialog is available to allow the user to alw
method of choice when in Review: 
ays open t
Open the method set used to acquire the data 
Open a specific, user-defined method set 
Create a new method set 
The user also has the ability to automatically apply chosen method 
set. 
 he 
 F Functionality 
Not Present in 
QuickStart 
 Plot scrollbars can be turned on and off and saved as a preference. 
 When the calibration curve window is opened for a peak that was 
quantitated by another component’s calibration curve (using a curve 
 
 3-39 Waters Corporation 
 Empower Functionality 
3 ing the user of 
hoice of opening the component’s curve 
reference or a default peak), a dialog appears inform
this fact. The user has a c
(if any) or the reference curve. 
 The instrument method can be opened from Review. 
 Ability to create a timed group (of peaks) and exclu
peaks within the group. 
de any known 
 Ability to annotate the displayed plots with lines, arr
ellipses and text for display purposes or for printing. 
ows, boxes , 
 A privilege called “Modify Integration Parameters” is available to 
f a processing 
sing Method 
 
allow a user to change integration parameters (only) o
method even if the user does not have the Save Proces
privilege. 
 A privilege called “Modify Component Parameters” is available to 
 of a processing 
sing Method 
 
allow a user to change component parameters (only)
method even if the user does not have the Save Proces
privilege. 
 The toolbars in the Main Review Window are cust
existing buttons can be removed completely or
location on the toolbar. Also, the various buttons fro
can be combined into one toolbar. 
omizable. T
 moved to a different 
m all toolbars 
√ he 
 
choose between four symbols for peak markers – a tria
The peak markers can be customized in Empower. The user can 
ngle, 
r can use any f 
 valley. The size of 
 
diamond, x, or a hash mark (straight line). The use
the four symbols for peak start, peak end or peak
the marker can also be customized. 
 o
 The processing method is automatically applied to
Review upon creation of a method with the wizard. 
 the active data in 
 Auto-Peak Width and Auto Threshold functio
through a System Policy (Traditional integ
nality is available 
ration only). This 
idth and 
ers for a chromatogram, without any manual 
le with 
 is necessary.) 
 
automatically determines the appropriate Peak W
Threshold paramet
manipulation by the user. (This feature is availab
ApexTrack integration by default—no system policy
 If Auto-Peak Width and Auto Threshold are turned
processing method wizard adapts to this functionali
 on, the 
ty. 
 
 It is possible to define an internal standard(s) when us
processing me
ing the 
thod wizard. 
 
 Control samples can be defined, acquired and proces
‘Control Value’ and ‘% Deviation’ are determined
type. 
sed. The 
 for this sample 
 
 Calibration using Response Factors (set in the ‘Fit 
the Component tab) is available. 
Type’ field of 
 A processing method wizard is available to assist in t
a processing method. 
he creation of 
 During Traditional integration, a quadratic curve i
points at the top
s fit to the 5 
 of the peak (the apex point and the 2 points on 
either side) to determine peak retention time and height. This 
functionality can be turned off using a System Policy, in which case 
Millennium32 version 2.15 integration will be performed and the 
retention time is defined as the highest data point. 
 
 During ApexTrack integration, peak retention time and height are 
generally obtained using a 5-point quadratic fit. If a 5-point fit can 
not be obtained a 3-point quadratic fit or the time of the second 
derivative apex is used. 
 
 3-40 Waters Corporation 
3 curve, the 
 and reported. 
 
 Empower Functionality 
 When standard components are fitted on a calibration
‘Calculated Value’ and ‘% Deviation’ is determined
 When manual integration has occurred, the Integration Type field 
has occurred, 
 
uses lowercase letters. When automatic integration 
the Integration Type field uses capital letters. 
 Standards can be calibrated and samples can be 
component val
quantitated usi
ues expressed as either ‘Amount’ or ‘Concentration.’ 
 ng 
 Components may be manually identified using the M
Identify Peaks button. 
anually √ 
 Manually integrated or modified peaks are designated i
table by 
n the result 
a lowercase letter describing baseline type, as opposed to 
integration type 
ach peak in a 
 
an uppercase letter for automatic integration. Such 
parameters allow tracking of each change made to e
chromatogram. 
 
baseline under the desired peak, and saving the result.
Peaks may be manually integrated by using the mouse to draw a 
 Areas an
e has been 
 
d 
heights are automatically calculated after the baselin
drawn. 
 Automatically integrated peaks may also be manu
dragging either the
ally modified, y 
 liftoff or touchdown point. 
 b
 Manually integrated peaks may be used for any furthe
that an automatically integrated peak may be used for
r calculat n 
. 
 io
 System Suitability and other calculations may be performed on
y integrated peaks. 
 
manuall
Individual compo
internal standard, indepe
same method. 
The following
 nents may be quantitated based on height, area or 
ndently of all other components within the 
 
 chromatogram scaling choices are available: 
st peak 
Scale to baseline 
 
Autoscale 
Scale to highe
Scale to second highest peak 
Scale to % of highest peak 
 
Review Main Window Toolbar 
 
T lbar displays a series of shortc g quick access to 
th
 
he Review Main Window To
e pr
o ut buttons providin
imary commands in the Review Main window. 
 Function 
 The following tools are available: 
Chromatogram and Plot Toolbar 
a
ams are overlaid, 
selecting this command removes the overlaid chromatograms, 
plotting only the chromatogram selected in the 2D Channels table.
 Scale to Peak - Scales the selected chromatogram to the 
height of the selected integrated peak. If there are overlaid 
chromatograms, the software applies the scaling of the selected 
peak to the other overlaid chromatograms. 
Scale to Chromatogram - Autoscales the selected 
chromatogram (from the multiple overlaid chromatograms) and 
he following tools 
are not available in 
e QuickStart 
toolbar: Scale to 
Peak, Scale to 
Chromatogram, 
Autoscale, 
Manually Identify 
Peaks, Peak Apex, 
Peak Inflection, 
Peak Valley,Peak 
Offset, Maximum 
Overlay - Switches the overlays of all 2D chrom
listed in the 2D Channels table. When chromatogr
tograms 
T
th
Functionality 
Not Present in 
QuickStart 
 3-41 Waters Corporation 
 Empower Functionality 
3 grams
atogra
mato
 and lowest 
ration events 
tion property 
ppear as 
ou can click and 
ify the start or end 
n the 
perty tab. 
arkers in the 
n the form of 
e 
 of a "T" 
dicates the width of the retention time window for its 
l line in each 
tion time 
ponents 
 markers as 
omatogram, 
d peaks by 
k width value 
ich is applied to 
on. During peak 
sampling rate 
y 15 determines the 
 a single point in the 
lly copied 
 part of the 
cify “Use 
on”, Empower 
 
f and 
he signal) for peak 
am plot. 
ulates slope changes across three bunched 
shold value. 
e Processing 
g method). 
x Style Peak Width 
mination”, Empower software optimizes 
seline in the 
Chromatogram plot that does not contain peaks and is 
representative of baseline noise. 
Minimum Area - Automatically calculates the minimum peak 
area value required for a peak to be reported, based on a selected 
peak in the Chromatogram plot of the Review Main window. Any 
peak that has less than the minimum area requirement is not 
included in the peak results. 
Minimum Height - Automatically calculates the minimum 
peak height value required for a peak to be reported, based on a 
purity Pass 1-4 
ary match. 
These functions are 
ailable in the 
QuickStart menus. 
applies the scaling to the other overlaid chromato
Autoscale - Autoscales each overlaid chrom
highest and lowest points. If there is a single chro
. 
m to its 
gram, 
Im
and Libr
avAutoscale redraws the chromatogram to its highest
points. 
Show Events - Plots all detection and/or integ
specified in the Processing Method window (Integra
tab) on the displayed chromatogram. Event markers a
lines at the specified event start and end times. Y
drag the vertical line in each event marker to mod
time of an event. The modified event time also changes i
Processing Method window (Integration pro
Show Components - Displays component m
Chromatogram plot. Component markers appear (i
inverted Ts) within the Chromatogram plot, based on th
component data in the processing method. The width
marker in
corresponding component. You can drag the vertica
marker to modify the component retention times and reten
windows of an individual component or several com
proportionally. 
Manually Identify Peaks - Displays component
vertical lines on top of the integrated peaks in the chr
allowing you to manually re-identify any misidentifie
placing one of the lines on a peak 
Integration Toolbar 
Peak Width - Automatically determines the pea
that is used to calculate a data bunching factor, wh
the raw chromatographic data during peak detecti
detection, the integer product of Peak Width and the 
(at which the data was acquired) divided b
number of points bunched together to produce
chromatogram. The Peak Width setting is automatica
into the Processing Method window (and is saved as
processing method) Note: If the system policies spe
V3.0x Style Peak Width and Threshold Determinati
software uses the selected peak to set the peak width.
Threshold - Automatically determines the liftof
touchdown values (minimum rate of change of t
detection based on the baseline in the Chromatogr
Empower software calc
data points and compares this change against the Thre
The Threshold setting is automatically copied into th
Method window (and is saved as part of the processin
Note: If the system policies specify “Use V3.0
and Threshold Deter
integration only through zooming an area of the ba
 3-42 Waters Corporation 
 Empower Functionality 
3 view Main 
 the minimum height 
 included in the peak results. 
llows the user to draw lines, arrows, 
 
act Chromatogram – PDA/MS Option - Extracts a 
in the Contour 
ts spectra from 
view. 
nel Data – 
w from the 
d max plot is 
 instrument 
omatogram plot 
ed in the 2D Channels table. For MS 3D Channel Data – 
m (TIC) plot directly in Review 
 extracted TIC 
hromatogram plot and is listed in the 2D 
e Spectrum 
 the Spectrum 
e leading and trailing inflection 
e Spectrum 
used peaks or in 
mpare peak 
ra extracted 
k apex and 
seline from the 
nd of peak 
um Index property tab .
 Displays the 
noise angle is greatest, 
n - Displays the 
Maximum Impurity spectrum for the second purity pass. 
purity – Pass 3 – PDA Option - Displays the 
Maximum Impurity spectrum for the third purity pass. 
Library Match – PDA or MS Option - Displays the best 
library match found using the PDA or MS processing method 
parameters. 
selected peak in the Chromatogram plot of the Re
window. Any peak that has less than
requirement is not
Plot Annotations Toolbar 
Plot Annotations - A
boxes, ellipses and text on a plot before printing.
Extract Toolbar (PDA/MS Option) 
Extr
chromatogram from PDA data or MS data displayed 
plot of Review. 
Extract Spectrum – PDA/MS Option - Extrac
PDA or MS data displayed in the Contour plot of Re
Extract Max/TIC Plot - For PDA/MS 3D Chan
Extracts a Max Plot derived channel directly in Revie
data selected in the 3D Channels table. The generate
the entire wavelength range specified in the associated
method. The extracted max plot appears in the Chr
and is list
Extracts a Total Ion Chromatogra
from the data selected in the 3D Channels table. The
channel appears in the C
Channels table. 
SpectrumIndex Toolbar (PDA/MS Option) 
Peak Apex – PDA/MS Option - Displays in th
Index plot the peak apex spectra 
Peak Inflection – PDA/MS Option - Displays in
Index plot the spectra between th
points (approximate half-height) of the peak. 
Peak Valley – PDA/MS Option - Displays in th
Index plot the spectra in the valley between two f
the baseline between resolved peaks. Allows you to co
maximum spectra with the valley spectrum. 
Peak Offset – PDA/MS Option - Displays spect
between the peak apex and liftoff and between the pea
touchdown. Offset is a selectable percentage of ba
peak apex to the start of peak detection and to the e
detection. Offset is specified in the Spectr
Maximum Impurity – Pass 1 – PDA Option -
spectrum where the ratio of purity angle to 
as calculated by Peak Purity testing. 
Maximum Impurity – Pass 2 – PDA Optio
Maximum Im
Maximum Impurity – Pass 4 – PDA Option - Displays the 
Maximum Impurity spectrum for the fourth purity pass. 
 
Processing Method Window 
 
Use the Processing Method window to define a processing method. The window is divided into 
multiple property tabs in which you enter application-specific information to customize 
 3-43 Waters Corporation 
 Empower Functionality 
3 
ntitate unknowns, enter component 
information, and define option-specific processing parameters. 
ng property tabs are available: 
 
nts 
ounts 
atch option) 
stem Suitability option) 
 option) 
• Noise and Drift 
• DA option) 
•
 
integration, define how to calibrate standards and qua
 
The followi
• Integration
• Compone
• Default Am
• Named Groups 
• Timed Groups 
• Pattern Match (Pattern M 
• Suitability (Sy
• Limits (System Suitability
 Purity (P
 PDA Library Search (PDA option) 
 Function 
The Inte
chromatogra
include the follo
Peak Width 
Threshold 
Minimum Area 
Minimum Height 
Start (ApexTrack integration only) 
End (ApexTrack integration only) 
Liftoff % (ApexTrack integration only) 
Touch
Vari
The Compon
calibration and quantitation are to be performed, an
each other as 
Average By 
Upda
Na
Mig
RT W
MT Wi
Peak Match 
Y Value 
Fit 
Weighting 
Internal St
 gration tab defines detection/integration parameters for the entire 
m, and defines time-specific detection/integration events. Fields available 
wing: 
down % (ApexTrack integration only) 
ous Integration Events 
 ents tab describes the sample components to be calibrated/quantitated, how 
d how these components are related to 
peaks in a chromatogram. Fields availableinclude the following: 
te RT 
me 
Retention Time 
ration Time (CIA/CE Option, replaces Retention Time) 
indow 
ndow (CIA/CE Option, replaces RT Window) 
X Value 
d 
RT Reference 
Rel Resol Reference (System Suitability Option) 
Curve Reference 
Relative Response 
Must 
Default Pk 
Default Pk Start, Default Pk End 
Default Units 
 3-44 Waters Corporation 
 Empower Functionality 
3 mpRef2, CCompRef3 
Type 
CCompRef1, CCo
CConst1 through Cconst7 
 The Default Amounts tab defines component quantities for each stand
internal). 
ard (external or 
 The Named Groups tab groups peak by name, allowing you to group
together for processing as a single pea
 individual peaks 
k. 
 The Timed Groups tab groups peaks within a specific time windo
group individual peaks together as a single peak. 
w, allowing you to 
 The Pattern Match tab defines chromatogram regions to align and compare. The 
alization, or 
 when the Pattern 
selected regions can be superimposed, compared after max-min norm
compared after alignment. (The Pattern Match property tab appears only
Matching option is installed.) 
 The Suitability tab defines system separation and efficiency parameter
baseline noise and drift measurements. (Suitability and Limits property 
s, as well as 
tabs appear only 
when the System Suitability option is installed.) 
 The Limits tab specifies the error and warning limits that can be set indi
peak values can be monitored as part of System Suitability testing. (Su
proper
vidually so that 
itability and Limits 
ty tabs appear only when the System Suitability option is installed.) 
 The Noise and Drift tab specifies a section of the chromatogram to be used to calculate 
th to calculate average detector 
e ASTM noise and drift 
detector noise, drift, peak to peak noise and a segment wid
noise and drift. These calculations are nearly identical to th
calculations. 
 Additional PDA-Specific Processing Method Property Tabs 
The Purity tab defines parameters used in determining PDA peak purity. 
earch tab defines how to match PDA peak apex spectra with PDA 
library spectra. 
 
 
The PDA Library S
 Additional MS-Specific Processing Method Property Tab 
 
 with MS The MS Library Search tab defines how to match MS peak apex spectra
library spectra and specifies. 
Results Window 
 
The Results window displays the results associated with the current chromatogr
2D Channels table in the Review Main window (and plotted in the Chromatog
 
 
am selected in the 
ram plot). The 
Results window displays individual peak results (such as Component Name, Retention Time, 
atogram results (such as Sample Name, Sample Type, Date Processed, 
Processing Method Name), calibration curve results (such as the equation of the line, R, R², Std 
 plot, and triple 
iscosity results 
quadruple plot (pattern 
 the processing 
method type (LC, GC, IC, GPC, PDA, MS, or CIA/CE). 
 
Calibration Curve Window 
 
The Calibration Curve window displays the current calibration curve and calibration data for the 
current processing method and 2D channel selected in the 2D Channels table (of the Review Main 
window). The calibration curve data is based on the component information listed in the 
Components table (Component property tab of the Processing Method window). Once standards 
Area, Amount), chrom
Error); purity results and purity plot (PDA); library match results, library match
match plot (PDA/MS); molecular weight distribution results and plot (GPC/V); v
and viscosity law plot (GPCV); Pattern Match results and Pattern Match 
match). The type of results displayed in the Results window varies according to
 3-45 Waters Corporation 
 Empower Functionality 
3 
Empower software generates a calibration curve for each component listed in the 
Components table. 
Use the Method Set Editor to create/modify a method set by specifying an existing instrument 
ng method, report method, and/or export method. 
 
 peaks and to perform spectral 
matching against a library or libraries. 
 
U t a library or libraries. 
 
are processed, 
 
Method Set Editor 
 
method, processi
PDA/MS Functionality 
 
Use the PDA functionality to determine the spectral homogeneity of
se the MS functionality to perform spectral matching agains
 Function 
 Ability to extract MS and PDA spectra with a right click in Review. 
 Ability to extract MS and PDA chromatograms with a right click in Review. 
 Chromatogram and spectral markers can be moved using the Up/Down a
Down keys on keyboard. 
nd Page Up/Page 
 MS and PDA spectra and chromatograms are extracted in real time as a marker is dragged 
across the Contour Plot in Review. 
 Ability to automatically create a timed wavelength derived channel (based on
and lambda max of integrated peaks). 
 the times 
 can be displayed. The MCA spectrum
After a pea
name as the defau
The PDA lam
 The following plots are modified to utilize a ‘sparse’ data file format 
MS spectra/library plots 
Contour plots 
Spectrum index plots 
MS triple plots 
 
chromatogram with the mouse. 
Ability to combine and average MS spectra by dragging across a section of the 
 Ability to use multiple regions of an MS chromatogram as a background spectrum which 
d spectrum. in turn is subtracted from all peak spectra to produce the extracte
 
different channel than the peaks of interest). 
Ability to use a Cross Channel Internal Standard (an internal standard peak from a 
 An extraction tolerance (+/- AMU) is available in MS processing me
The Spectrum Review table allows the Noise Threshold
and changed to a new value. 
 MS continuum spectra can be displayed as centroid spectra. 
 MS chromatograms and spectra can be exported directly to ACD/Labs s
 k has been calibrated or quantitated, Spectrum Review uses that component 
lt spectrum name. 
 bda max of the peak apex spectrum is added to the peak table in Review. 
thods. 
 and Peak Separation to be edited 
oftware. 
 Spectra from different channels can be displayed simultaneously in Spectrum Review. 
 Peaks can be annotated with their corresponding spectrum name or component name. 
 Extraction of a max plot is available in the processing method wizard. 
 The Wiley and WileyNIST MS spectral libraries contain the chemical structures as well as 
spectral information. When a MS extraction is searched against either of the Wiley 
libraries and a library match is found, the chemical structure for the spectrum is drawn in 
the plot along with the spectrum. The following plots show the Wiley structures when a 
 3-46 Waters Corporation 
 Empower Functionality 
3 s occurred: 
 Review 
trum Index 
h Plot 
Triple Plot 
Wiley match ha
Spectrum
Spec
Matc
 
Report Publisher 
 
 a graphical interface that lets you interactively create and modify the 
contents and design of your report method, including placement and design of custom report 
rmat a report of 
 
ort groups and 
rance in a 
s tree lists all available groups in a project, including those provided in 
the Empower software and all custom report groups created in the project. The types of report 
 calibration curve groups, 
ps, Dissolution 
 
 cement, and 
is page represents 
ired. You define 
 
er includes a Preview function that displays data (sample sets, injections, 
ributions, spectra, 
a, and pattern match data) based on a report method before you generate 
the report. After you access Preview with data, the contents of the individual report groups in the 
Report Publisher are updated to reflect the actual data. 
 
General Functionality 
 used in the QuickStart interface, new report 
 
The Report Publisher is
groups. The report method instructs Empower software how to construct and fo
selected project data or results. 
The Report Publisher includes the Report Groups Tree which is a collection of rep
fields defined in some specific manner to provide a level of information and appea
report. The Report Group
groups include, but is not limited to, chromatogram groups,table groups,
method groups, drawing object groups, PDA/MS groups, System Suitability grou
groups and Pattern Match groups. 
The Report Publisher includes the Report Page which displays the order, pla
orientation of the groups that are included in the actual report. Each block on th
a report group. The groups on this page can be dragged to new locations as des
the order, placement, size, and orientation of the report groups. 
The Report Publish
channels, methods, result sets, results, calibration curves, molecular weight dist
libraries, dissolution dat
Note: Although existing report methods can be
methods cannot be created.
 Function 
 The user can specify that a report can (or cannot) be used to √ 
electronically signoff results. 
 When using Scaling to % of Highest Peak, values g
100% are allowed. 
reater than √ 
 Undo/Redo is available in the Edit me
Functionality 
Not Present in 
QuickStart 
nu in the Report Publisher √ 
 Composite groups can be edited without ungrouping them √ 
 Extend Group to Fit text check box available in Field Properties 
 Multiple groups on the report page can be moved simultaneously √ 
 An annotation bar is available in Print Preview. This toolbar allows 
the user to draw lines, arrows, boxes, ellipses and text on a given 
report page before printing. These annotations affect the current 
report only and are not part of the report method. 
 
 3-47 Waters Corporation 
 Empower Functionality 
3 by tab) allows 
s. This 
 you to specify which data to report, as you can 
√ A Data Filtering Conditions button (in the Order 
more functionality, similar to that found in view filter
functionality allows
currently do in view filters. 
 Ability to report the method history of the report method using √ the 
Revision Summary Information check box. 
 Ability to print Differences from Previous Version on a method. √ 
 The Message Center is no longer used to report error i
for the report publisher. Errors are added to the s
nformation 
tatus bar of the 
s still remaining on the report itself. A list 
of vailable using the new Errors button in the Report 
Pu
 
report publisher as well a
 errors is a
blisher toolbar. 
bility to m
Paper size 
Paper orientation 
Font size 
 Ability to set a ‘global’ font for each report method. √ 
 Ability to specify and modify the default methods (used when you 
 be appropri 
√ 
choose ‘Use a report method that was generated to
for the selected data’). 
ate
 Ab ecify and modify thility to sp e default groups that appear in the 
R tree. 
√ 
eport Publisher
e Special Informati
eces of information that is
d 2 pieces of rep
User name 
Company name 
Support plan number 
Report method ID 
 Ability to use printer defaults for paper size and orientation. This 
ed by the prin r 
 report methods hav 
 have this feature 
√ 
allows the paper size and orientation to be govern te
setup rather than in the report method. New
this feature turned on. Updated report methods
e
turned off. 
 Report page length in the editor is 25 pages (was prev
pages). 
iously 2 √ 
 In a Full Audit Trail project, a user cannot print a report with a 
. 
 
modified, unsaved report method
 The report method used to sign off a result is traceable. 
 A plot scaling privilege called “Modify Report Scaling Only’ is 
 property sheet 
s that are part of a report method (including locked 
√ 
available to allow a user to be ale to edit the Scaling
only on plot
methods). The method is not overwritten. 
 A Result Custom Fields group is available. 
 A odify default settings: √ 
 Th on report group is modified to report the 3 
pi entered during software installation 
an orting information: 
Job ID for report generation 
√ 
√ 
 A Project Custom Fields group is available. √ 
 A Sample History group that tracks changes made in Alter Sample 
is available. 
√ 
 ‘Ordering’, ‘Grouping’ and ‘Summary Functions’ are available in 
calibration tables. 
√ 
 An Acquisition Log groups, which track acquisition history is 
available. 
√ 
 A Sign Off Log group which lists any sign off information is √ 
 3-48 Waters Corporation 
3 
 Empower Functionality 
available. 
 Any plot group is allowed to be rotated. √ 
 A Project Information group is available. √ 
 The current report can be saved in PDF, EMF and ASCII forma t. 
 Reports may be emailed in PDF, EMF and ASCI
MAPI complia
I format using 
nt mail system. 
 a
 A result(s) may be electronically signed off by a user
appropriate privileges. 
 with the 
 The ‘Result Sign Off’ capability complies w
Electronic Signatures General Requirements 21 CFR Part
part C. For example, Empower imparts the ability 
ith Closed System 
 11 Sub-
to use ‘Unique 
ser Passwords’ and ‘Unique 
ed Access Attem 
 ‘Sign Off Meanings’ and has a ‘Sign Off Inactivity Delay.’ 
 
User Accounts,’ ‘Expiring U
Passwords.’ The software reports ‘Unauthoriz
uses
pts’ 
 The Report Groups Tree is searchable. √ 
 The ability to expand or collapse the Report Groups Tree is 
available. 
√ 
 Header/Footer vs. Main view is available in the Report Publisher. √ 
 A Wizard is available to assist in the creation of a
or a report method. 
 reporting gro √ up
 Reporting groups may be renamed, cut, copied, pasted, dragged and 
dropped. 
√ 
 ‘Snap to Grid’ and other alignment tools (such as ‘Make Same 
Size’ and ‘Align Right/Left’) are available for ease in formatting 
√ 
your reports. 
 
 
Ch er Plot Groups 
 
C m groups define the parameters to use when printi hic plots, 
including specific plot characteristics, data characteristics, ove and so on. 
 
used in the QuickStart interface, new report 
romatogram and oth
hromatogra ng chromatograp
rlay information, 
Note: Although existing report methods can be 
methods cannot be created. 
 Function 
 In a chromatogram group, “Scale to Highest Peak” allows √ 
percentages above 100 % (500 % is the maximum). 
 Chromatogram scaling features are now available in the Spectrum √ 
Index Plot. 
 Plot properties are expanded to include settings for the right and top √ 
axis. 
Functionality 
Not Present in 
QuickStart 
 Plot characteristics, such as x-and y-axis labels and units, the grid 
box, etc. can be chosen to be printed or not printed. 
√ 
 The x- and y- axis units are customizable. √ 
 Chromatograms and pump gradients can be overlaid in a single or a 
stack plot. 
√ 
 Peaks can be labeled with start/end markers, apex markers, 
component name, retention time etc. 
√ 
 Peaks can be labeled with its library match (PDA/MS options only) √ 
 3-49 Waters Corporation 
 Empower Functionality 
3 only). or the scan number (MS option
 Peak name placement can be customized. √ 
 Peak start/end/apex markers are custom
Available
Autosc
Normalized 
Highest Pea
Second H
% of Highest Peak 
Scale to Baseline 
 Chromatogram plots can be rotated on the report page. √ 
 Chromatogram plot titles can be assigned. 
izable and sizable. √ 
 chromatogram scaling is the following: 
ale 
k 
ighest Peak 
√ 
√ 
 Legends can be created using user defined fields. √ 
 Chromatogram plots can be ordered by a user-defined field(s). √ 
 The fonts and colors of a chromatogram can be customized. √ 
 
able Groups 
 parameters to use when printing Empower database fields in a tabular 
f
 
Note: Although existing report methods can be used in th face, new report 
T
 
Table Groups define the
ormat. 
e QuickStart inter
methods cannot be created. 
 Function 
 
table. 
Functionality 
Not Present in 
QuickStart 
Nearly any field stored in the database can be printed in a report √ 
 blSummary ta es called ‘Component Summaries’ are available. √ 
 The user can choose to print or to not print specific types of peaks √ 
such as known, unknown, missing, internal standards, etc. 
 The data in tables can be ordered by a user-defined field(s). √ 
 The fonts and colors of a table can be customized. √ 
 
C lib rve Groups 
 
LC calibration curve groups definethe parameters to use when curve 
c
 
 the QuickStart interface, new report 
a ration Cu
 printing specific
haracteristics, data points, and so on. 
Note: Although existing report methods can be used in
methods cannot be created. 
 Function Functionality 
Not Present in 
QuickStart 
 Ability to skip the printing of the internal standard’s calibration 
curve (using the Data Filtering Conditions button). 
√ 
 Plot characteristics, such as x-and y-axis labels and units, the grid 
box, etc. can be chosen to be printed or to not printed. 
√ 
 3-50 Waters Corporation 
 Empower Functionality 
3 id in a single or a stack plot. √ Calibration curves can be overla
The followi
Scale to
Scale to Curve 
Normalize 
Calibration plots can be rota
 Calibration plot titles can be assigned. √ 
 Legends can be created using user-defi
 ng scaling types are available: 
 Point 
√ 
 ted on the report page. √ 
ned fields. √ 
 The data in tables can be ordered by a user-defined field(s). √ 
 The fonts and colors of a table can be customized. √ 
 
 
ters) that is associated 
with one or more pieces or data. 
 
Note: Although existing report methods can be used in the Qui new report 
methods cannot be created. 
Method Groups 
Method groups allow you to automatically print the method (and its parame
ckStart interface,
 Function Functionality 
Not Present in 
QuickStart 
 Method-specifi
customizab
c items to include on the printed report page are 
le. 
√ 
 User-defined field(s) can order the data in tables. √ 
 The fonts and colors of a table can be customized. √ 
 
ups 
 
D t groups allow you to customize your reports usi , graphics (bitmap 
files or enhanced metafiles), and/or lines. 
 
N t methods can be used in the QuickStart terface, new report 
m
Drawing Object Gro
rawing Objec ng Text, borders
ote: Although existing repor in
ethods cannot be created. 
 Function Functionality 
Not Present in 
QuickStart 
 All drawing objects are sizeable. √ 
 The fonts and colors of these objects can be customized. √ 
 
 
PDA/MS Groups 
 
PDA/MS Groups define the parameters to use when printing PDA- and MS-related data. 
Including 3D plots, MS comprehensive status reports, contour plots, extracted spectra and 
extracted chromatograms, library match plots, peak purity plots, spectra/library plots, 
spectra/library tables, spectrum index plots, and triple library match plot. 
 
 3-51 Waters Corporation 
 Empower Functionality 
3 
port methods can be used in the QuickStart interface, new report 
methods cannot be created. 
Note: Although existing re
 Function Functionality 
The following grou
3D Plo
Comp. Status R
Contou
Extracted Spe
Match Plots 
Purity Plots 
Spect
Spectra/Library Tables
Spectrum Index Plots 
Triple Plots 
MS Internal Standard Peak Plot 
MS Internal Standard Peak Table 
 In MS Stick Plots, the vertical mass intensities are shown as 
e the axis
√ 
originating at the bottom axis of the plot, not 5% abov . 
Ability to change the scale 
Each amplifier fro
the regions sp
 The following plots are modified to utilize a ‘sparse’ d
MS spectra/library plots 
Contour plots 
Not Present in 
QuickStart 
 ps are available: 
ts 
eports 
r Plots 
ctral Plots 
ra/Library Plots 
 
√ 
 on user-selectable regions of the plot. √ 
 m the amplification table is applied to the plot for 
ecified, including the start and end region values. 
√ 
ata file format 
ndex plots 
MS triple plots 
√ 
Spectrum i
 When MS spectra are matched from either the Wiley or WileyNIST 
libraries, the chemical structure can be drawn in the Match Plot, 
Triple Plot or Spectrum Index plot. 
√ 
 
System Suitability Groups 
 
System Suitability Groups define the parameters to use when oups related to the 
System Suitability option. 
 
Note ng report methods can be used in the QuickStart interface, new report 
meth be created. 
printing special gr
: Although existi
ods cannot
Function 
 The follo
 Functionality 
Not Present in 
QuickStart 
wing groups are available: 
Overall RSD Plots 
Peak Plots 
RSD Plots 
Summary Plots 
√ 
 The x-axis of summary plots can be customized with a user-defined 
field from the database. 
√ 
 Warning level control lines are available in system suitability 
summary plots. 
√ 
 3-52 Waters Corporation 
 Empower Functionality 
3 
 
 
specific information. 
 
Note: Although existing report methods can be used in the QuickStart interface, new report 
m not be created. 
 
Dissolution Groups
 
Dissolution Groups define the parameters to use when printing Dissolution-
ethods can
 Function Functionality 
Not Present in 
QuickStart 
 The following groups are available: 
Dissolution Plots 
lution Tables 
√ 
Disso
 
 
attern Match Groups 
 
s define the parameters to use when printing Pattern Match-specific 
in
 
Note: Although existing report methods can be used in the Qu , new report 
methods cannot be created. 
P
Pattern Match Group
formation. 
ickStart interface
unction F Functionality 
Not Present in 
QuickStart 
 The following groups are available: 
Pattern Match Quadruple Plots 
 Result Parameters 
√ 
Pattern Match Out of Bounds Tables 
Pattern Match
 
 
C em cture Groups 
 
Chemical Structure Groups define the parameters to use when pr that contain 
c
N e QuickStart interface, new report 
m eated. 
h ical Stru
inting results 
hemical structure information. 
ote: Although existing report methods can be used in th
ethods cannot be cr
Function Functionality 
Not Present in 
QuickStart 
 The location of the structures in relation to its corresponding peak 
can be defined: Automatic, Above Peak, Left of Peak, Right of 
Peak and Inside Peak. 
√ 
 The following groups are available: 
Chemical Structure fields 
Chemical Structure Plots 
Chemical Structure Library Plots 
√ 
 3-53 Waters Corporation 
 Empower Functionality 
3 Preview 
en printed. In 
 
 method in Report 
Publisher to modify the report’s appearance. Preview uses the active report method (from Report 
ify a different report method to view the report. 
 
iew before you print it. 
 
The Pre nsists of the following buttons: 
Open 
Send Mail 
port 
Print 
te 
ious Page 
e 
oggle Number of Pages 
 In 
 Out 
eport 
ue 
Next Report 
• Sign Off 
ions 
nnotations 
le functionality. 
un samples and get answers is located in one place. By using a streamlined 
 as accessible to the 
 different 
user to enter sample information, select acquisition methods and view 
d for and 
taken into Alter Sample, Processed, etc. 
• View Data-allows interaction with data selected within the current project. This view provides 
access to Review and Preview. 
• View Methods-Allows the user to view, create and/or modify methods. Once View Methods is 
selected, three additional options are available in the Navigation Bar: Method Set, Instrument 
Method and Processing Method. 
• Show Me-allows the user to be lead through the process of common tasks. This Help system 
drives the user through the desired process, in essence it presses the appropriate menus and 
buttons to guide the user to the completion of the chosen task. 
Preview is a tool within Report Publisher that you use to view a report as it will appear wh
addition, you can use Preview to review and sign off results (subject to privilege control). 
If the appearance of the report is not satisfactory, you can make adjustments to the report
Publisher) as the default report method, but you can spec
You can add annotations to the report in Prev
view Toolbar co
• 
• 
• Save Re
• 
• Cut 
• Copy 
• Pas
• Prev
• Next Pag
• T
• Zoom
• Zoom
• Previous R
• Que
• 
• Annotat
• Clear A
• Close 
• Help 
 
QuickStart Interface 
 
The QuickStart Interface is a simple, single window that optimizes access to availab
Everything required to r
interface, QuickStart takes the software’s performance features and makes then
occasional user as they are to the everyday user. 
QuickStart consists of the followingmain buttons in the Navigation Bar which allow
information to be displayed in the work area: 
• Run Samples-allows the 
real time data acquisition. 
• Browse Project-provides access to the Project window where data can be searche
selected. Data can then be Reviewed, Previewed, 
 3-54 Waters Corporation 
 Empower Functionality 
3 isition bar, allowing the user to allocate more 
screen real estate to the top portion of the QuickStart window. 
General ality 
• View Acquisition-controls the display of the acqu
 
 Function
 Function 
 A user has the ability to use QuickStart whether or not they are connected to a chro
system. 
T e Command bar occupies the left side of the QuickStart window and prov
bs with the following functionality: 
• Run Samples – allows the user to display either the Sample Qu
sample information, select acquisition methods and view real time data acquisition 
the System Status, which includes the instrument control panels and th
Refer to the Pro Interface Run Samples section for details on func
• Browse Project – allows
various views. When data is selected, buttons which allow the user t
Preview or Report the data are enabled. Refer to the Pro Interface P
section for details on functionality. 
• View Data – allows the user to display data in either Review mode or
View Data retains the selected data until it is replaced by subsequent 
user switches 
the same data as it previously contained. When bringing data into
is possible to ‘replace’ the current data with the new data or to ‘ap
with the new data. Refer to the Pro Interface Review Window and
details on functionality 
• View Method – allows the user to create, open, edit and save instru
processing methods and method sets. 
• Show Me – allows the user to start the Show Me Help Tool. This too
guides the user through common tasks. 
• View Acquis
which contains the real time plot. Turning off the Acquisition Bar a
allocate more scree
Acquisition Bar is not displayed if QuickStart is being run with no
 The Make Single Injection button is enabled whenever the system is idle and allows the user to 
quickly make single injections. 
 A Do Last functionality is available to allow the user to quickly re-acquire the l
single injection, template method, etc. 
ast sample set, 
 When data is being Review in the QuickStart work area
matographic 
 h ides the following 
ta
eue in order to enter 
or 
e real time plot. 
tionality. 
 the user to see information in the project window using the 
o Review, Process, 
roject Window 
 Preview mode. 
data; i.e. if the 
to a different view and then returns to View Data, the window contains 
 the Review mode, it 
pend’ the current data 
 Preview sections for 
ment methods, 
l interactively 
ition – allows the user to toggle on/off the display of the Acquisition Bar 
llows the user to 
n real estate to the work area of the QuickStart window. The 
 connection to a 
system. 
, the user has the ability to Clear All 
Data. 
 Configuration Manager is available through the Manage menu in QuickStart. 
 When in the QuickStart window, the user has the ability to switch between projects and systems. 
 Upon login, Show Me Help appears by default. This setting can be disab
Me Help does not automatically appear but can still be started using the 
Me Help is an interactive help utility that guid
led so that the Show 
Show Me button. (Show 
es the user through the completion of common 
tasks, bringing the user to each area of the software when necessary. ) 
 
Open Access Interface 
 
Open Access is a productivity tool. The Open Access application is designed to ease the process 
of sample submission and acquisition and allow users that are unfamiliar with Empower to fully 
acquire and process data and also report and/or email the results. 
 
The Open Access user needs to provide only minimal information about their sample(s) such as 
vial position, injection volume and run time. All methods such as instrument methods, processing 
 3-55 Waters Corporation 
 Empower Functionality 
3 
 more experienced Empower user. The 
Open Access application can be designated as the default user interface. 
 and regulates the Open Access user’s privileges, typically 
restricting these privileges fairly dramatically. 
We
 data across a 
r the internet. This interface provides read-only access to data that resides 
inside the Empower database on a computer running only a web browser such as Microsoft 
d to have a full install 
 the Web 
current 
t their access privileges allow. 
Browsing information in the project works very similar to the way it does in the Empower Project 
 or results, and then 
 filters must first be 
The Web interface also provides the ability to generate Empower Reports, (Single or multiple 
 Web browser 
d in the browser, 
d. Users can also 
us of a running chromatographic system, select a system from the drop 
he Review Acquisition button. A page will display the status of the 
 sample set in the Adobe Acrobat format. Users will see information such as the 
current vial, injection number, and runtime. From the Preferences page, users can set the PDA 996 
sh rate for the real time data plots. 
Em
methods and report methods are created ahead of time by a
 
The system administrator determines
 
b Interface 
 
The Web interface is a web-based solution that makes it easy to share Empower
company intranet o
Internet Explorer or Netscape Communicator. The computer is not require
of the Empower software. 
All Empower security features and access privileges are still in effect when using
interface. After logging in, users can review previously collected data, or review 
acquisition in real time from any chromatographic system tha
Window. Users select a Project view such as sample sets, channels, methods,
apply a view filter to drill down to the information you are searching for. View
created in the Empower software before they will appear in Empower Web. 
results may be selected in the Review Data project page) which are viewed in the
using the Adobe Acrobat Reader plug-in. The report format cannot be modifie
however these reports may be printed to a local printer, saved to disk, or e-maile
zoom in or out using commands provided by the Adobe Acrobat Reader. 
To look at the real time stat
down list box and click on t
currently running
wavelength to view, TMD mass to view, and refre
power Software Options 
tem Suitability Option 
rocessing and Reporting System Suitability Results 
 
The Empower System Suitability software is an optional software ap
Sys
P
plication that is fully 
integrated into the Empower software. This software option provides System Suitability testing 
A, and MS 
lations on results and 
ility, you can 
uce reports that show the statistical accuracy and reproducibility of your chromatographic 
data. The Empower System Suitability software bases its System Suitability tests on standard 
laboratory calculations, including the United States Pharmacopoeia (USP), European 
Pharmacopoeia (EP), and Japanese Pharmacopoeia (JP) guidelines and calculations. 
 
The System Suitability option allows you to test your chromatography system to ensure that it is 
working within acceptable limits. As described in the United States Pharmacopoeia (USP), 
suitability testing is the concept that the electronics, equipment, specimens, and analytical 
operations constitute a single analytical system, which is amenable to an overall test of system 
function. 
and methods validation parameters for use in LC, GC, IC, CIA/CE, GPC/V, PD
chromatography applications. System Suitability performs statistical calcu
summarizes the information in graphical or tabular formats. With System Suitab
prod
 3-56 Waters Corporation 
 Empower Functionality 
3 f detection, limit 
 The usual practice is 
cessing method and method set. The System 
l for methods validation. 
 
e to help: 
rmance of your system 
P c
 
 
Methods Validationis the process of determining the precision, accuracy, limit o
of quantitation, specificity, range, linearity, and robustness of your method. 
to perform method validation once for each pro
Suitability software is a useful too
Use the System Suitability softwar
 
• Ensure the perfo
• Validate methods 
• Track and trend results. 
 
ro essing System Suitability Results 
Function 
The following Sy
2 Sigma
3 Sigma Plate Count 
 Sigma P
5 Sigm
Asym
Asym @
Asym @ (
As
Asym @ 4.4 
EP P
JP Plate C
USP Plat
K Prime 
Relative Reso
Selectivit
Symmetr
USP Re
USP R
USP Tail
Width @ 1
Width @ 1
Width @
Width @
Width @ 5% 
Width @ 50% 
Width @ 60.7% 
Width @
Baseline Drift 
 
 stem Suitability fields can be calculated by the software: 
 Plate Count 
late Count 
a Plate Count 
 (Tailing) 
 (10)² 
4.4)² 
ym @ 10 
late Count 
ount 
e Count 
lution 
y 
y Factor 
solution 
esolution (HH) 
ing 
0% 
3.4% 
 32.4% 
 4.4% 
Width @ Baseline 
 Tangent 
Baseline Noise 
f @ 5% 
 There are two parts to the System Suitability processing method: the Suitability tab and the 
Limits tab. 
 The Suitability tab contains the following parameters: 
 
General Parameters 
Calculate Suitability Results 
 3-57 Waters Corporation 
 Empower Functionality 
3 nknown Peaks 
ration Efficiency Parameters 
 Time (min) 
Pharmacopoeia Options 
on of System Suitability results according to the formulas outlined in 
European Pharmacopoeia (EP) 
specified Pharmacopoeia, System Suitability results such as selectivity, plate 
count and resolution are calculated according to the associated formulas.) 
ement Parameters 
able Noise 
Calculate Suitability Results for U
System and Sepa
Void Volume
 
Specifies the calculati
the 
US Pharmacopoeia (USP) 
Japanese Pharmacopoeia (JP) 
All 
(Based on the 
Tangent Percent 
Plate Count Type 
 
rift MeasurBaseline Noise and D
Maximum Allow
Maximum Allowable Drift 
% of Run Time Over Which to Average 
Baseline Start Time (Min) 
Baseline End Time (Min) 
 The Limits tab allows you to define the range of allowable values you set for each peak that 
is testing. The System Suitability limits you set are used to 
de es in summary charts, to flag result 
fie mmary tables, and to fault out-of-range values in printed reports and in the Peaks 
ta
Th e following parameters: 
 Values Outside Limits 
for example, Area, RT, Resolution, Plate Count) 
mit (LCL) 
 Error Limit (UCL) 
Lower Warning Limit 
it 
Ignore Blank Values 
Check Limits 
 to have system suitability
termine limits shown as minimum and maximum valu
lds in su
ble in Review. 
e Limits tab contains th
Flag
Field Name (
Error % 
Lower Error Li
Upper
Warning % 
Target 
Upper Warning Lim
 Ability to always check system suitability limits or to only check them during calibration or 
quantitation. 
 
ng System Suitability Results 
 
Warning limits are available in addition to the upper and lower error limits. 
 
Reporti
 Function 
 You can present System Suitability data in the following formats on a report: 
 
Summary Plots – Summarizes data for the analysis you select. Can be plotted in 
line, bar, or scatter format. Useful for observing trends. 
Overall %RSD Bar Plots – Summarizes all peaks for an overall report of System 
Suitability. 
RSD Bar Plots by Peak – Identifies the problem area when you have a questionable 
 3-58 Waters Corporation 
3 
atistics. 
 Empower Functionality 
Overall %RSD plot. 
Peak Plot – Illustrates the plate count calculation. 
Summary Tables – Present summary data in table form, and calculate st
 Sample-, Injection-, chromatogram- and peak-level fields are available for use in System 
Suitability Reports. 
 
Pattern Matching Option 
ematically compares 
 to a method-specified reference chromatogram and identifies retention-
You can compare 
ray (PDA) or 
Pattern Matching uses an alignment algorithm to compare corresponding retention-time intervals 
 the data. Internal 
ot required nor is traditional integration used. The alignment algorithm measures 
 caused by the following five system variables: 
 
 ratio (between corresponding retention-time intervals of the reference and sample 
grams) 
 
e chromatograms are the 
same and are present in the same concentration ratio, the patterns match (align). If there is a 
reference and sample chromatograms (for example, a new or missing peak 
or a difference in concentration ratios), the degree of alignment is less. After aligning the 
e differences 
nment. 
 
Chromatographic Pattern Matching is an Empower software option that math
a sample chromatogram
time intervals where the compared chromatograms have significant differences. 
any 2D channel data, including channels extracted and saved from photodiode ar
mass spectrometry (MS) data. 
in the reference and sample chromatograms. The algorithm operates directly on
standards are n
and removes changes
• Response
chromato
• Retention time offset 
• Retention time scaling 
• Baseline offset 
• Baseline slope 
If the components in the compared intervals of the reference and sampl
difference between the 
chromatograms, the algorithm calculates the standard deviation (Std Dev) of th
between the compared retention-time intervals to quantify the degree of misalig
 
rchive Option 
AutoArchive is an Empower software option that automatically backs up p
on a schedule determined by the user and also provide
AutoA
roject data based 
s a mechanism to locate samples after 
n archived. You can easily retrieve archived data because samples are logged 
 generated and their location and status is tracked as they move through their 
oject and sample archive 
ation Manager allowing tracking, searching, and retrieval of 
projects and their samples. You can either manually archive a project and samples, or 
ws you to track 
they have bee
when they are
life cycle. To simplify the search and retrieval process, additional pr
views are displayed in Configur
schedule an archive task using the Windows® Scheduler. AutoArchive allo
project information, sample information, and sample custom fields. 
Method Validation Option 
Method Validation is an Empower software option that simplifies the validation of your 
processing method (instrument method also?) 
The Method Validation option will allow users to make calculations and produce reports for the 
following parameters: Linearity, Accuracy, Precision, Limit of Detection (LOD)/Limit of 
Quantitation (LOQ), Specificity and Robustness. This option involves a method validation 
 3-59 Waters Corporation 
 Empower Functionality 
3 
ew validation results as well as 
additional reporting capability, to allow users to report validation information. 
the project from which users can “View As” “Results”, 
The Signoff feature in Preview will be modified to allow the signoff of validation results in the 
sher contains the following method validation report groups: 
• Validation Method 
• Validation Results (for all functions tested) 
siduals Plot (linearity) 
• Linearity Plots (linearity of pharmaceutical form, active form and both overlaid or linearity at 
or Accuracy, Precision or LOQ) 
 
• Robustness Factor % of Variance Plot 
igma. 
application used to create validation methods and process and vi
A Validation Results view is available in 
“Result Sets”, “Signoffs”, or “Validation Methods”. 
same manner that regular results are signed off. 
The Report Publi
• %Re
the LOD) 
• %Recovery Plot (bar graph f
• Accuracy Profile Plot (calibration level vs. mean % recovery) 
• Retention Time Plots (at the mean, +/- 1sigma, +/-1.96 sigma and +/- 2.58 s
Ch ctures Option 
mical structures 
nd on Reports and also allows you to perform structure searching using 
 Basic and Advanced. 
e a standard file format in the industry, or MDL ISIS 
structures and allows you to: 
• Assign structures to components and spectra 
ts, triple plots and 
hing (whole molecule only) 
 
The advanced option is available through ACD Laboratories(Advanced Chemistry Development, 
www.ACDLabs.com) and provides all of the basic functionality plus: 
• Includes a Millennim32-enabled version of ACD’s ChemSketch structure drawing software 
that adds the ability to create and edit chemical structures directly from the Empower software 
• Allows sub-structure searching 
 
The basic option must be purchased before purchasing the advanced option. 
 
emical Stru
Chemical Structures is an Empower software option that allows you to place che
on your plots in Review a
view filters. Two levels are available: 
Basic Option 
The basic option uses *.MOL files, which ar
• Create structure libraries 
• Draw structures on chromatogram and spectral plots (also PDA match plo
purity plots) 
• Perform structure searc
Advanced Option 
 3-60 Waters Corporation 
 Empower Functionality 
 3-61 Waters Corporation 
3 
vailable in the Millennium32 software if the option 
en enabled (for up to 3 structures per component): 
 
ght 
• Formula 
 
information is available on reports in the following groups: 
 Structure library plots 
 
l Structures Option. 
View filters allow you to easily add a structure or other structural information to your search 
criteria and quickly retrieve all data that contains the criteria you defined. If you have the 
 Structures package, you can search using a substructure as your criteria. This allows 
you to search for similar, but not identical compounds. 
 
The following Chemical Structure fields are a
has be
• Name 
• Description
• Molecular Wei
• Structure 
Chemical structure 
• Structure plots 
•
• Existing plot groups (i.e. chromatogram plots, spectral plots, etc.) 
• Individual fields (Name, Description, Mol. Wt., Formula, Structure) 
Searching for structures and sub-structures is also available using the Chemica
Advanced
Dis
s an Empower option that allows you to automate dissolution testing from dissolution 
sampling and acquisition to dissolution calculations and data reporting. It can be run with Bath A, 
 – 8 vessels per bath. A wizard walks the user through the different 
 as transfer amounts and intervals, Q Factor information, temperature, 
rt your 
solution Option 
 
Dissolution i
Bath B or both baths with 1
dissolution parameters such
and paddle speed. Customizable dissolution plots and tables are available to repo
dissolution results. 
 
Ga
The Empower GC Option allows direct instrument control and digital data collection for Agilent 
Technologies gas chromatographs. The following GC instruments can be controlled: 5890 Series 
II, 7673 Automatic Liquid Sampler (ALS), 6890, 6890 Plus, 6890N, and 7683 ALS. When using 
two injectors, dual-tower injections are supported for analyses that require maximum throughput 
or compound confirmation. GC control through Empower Software is also compatible with 
manual injections and headspace analysis. 
s Chromatography (GC) Option51 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
Pr ... ...................... 
... ...................... 54 
... ...................... 55 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 
... ...................... 58 
... ...................... 59 
... ...................... 
Method Validation Option..................................................................................................................... 
Chemical Structures Option .................................................................................................................. 
Dissolution Option.................................................................................................................................. 
Gas Chromatography (GC) Option ...................................................................................................... 
Calibration Curve Groups......................................................................................... 50..
Method Groups.......................................................................................................... ..
51
Drawing Object Groups ............................................................................................ ..
52
PDA/MS Groups........................................................................................................ ..
53
System Suitability Groups.......................................................................................... ..
53
Dissolution Groups.................................................................................................... ..
53
Pattern Match Groups...............................................................................................
54
..
Chemical Structure Groups ....................................................................................... ..
55
eview ......................................................................................................................... ..
56
QuickStart Interface........................................................................................... ..
56
General Functionality ............................................................................................... ..
56
Open Access Interface ....................................................................................... ..
56
Web Interface ....................................................................................................
57
..
Empower Software Options............................................................................... ..
59
System Suitability Option ........................................................................................... ..
59
Processing and Reporting System Suitability Results................................................ ..
60
Processing System Suitability Results ....................................................................... ..
61
Reporting System Suitability Results ......................................................................... ..
61
Pattern Matching Option............................................................................................ ..
AutoArchive Option .................................................................................................... ..
 Empower Functionality 
 1-1 Waters Corporation 
1 
. . . . . . .. . . 
Section 1 - Introduction 
Basic 
Empower Software is an information management application for chromatography data. 
The application covers a comprehensive range of corporate laboratory concerns: 
ort 
formation Management 
ce (GLP/GMP/ER/ES) 
tion Availability 
5. Minimizing System Downtime 
6. Data Security, Change Control and Audit Trails 
7. Customization and Interaction with 3rd Party Applications 
Principles 
1. Comprehensive Applications Supp
2. Laboratory, Site and Enterprise Wide In
3. Regulatory Complian
4. Maximizing Instrument and Applica
What Makes
The unique properties of the Empower application available include: 
stems to fully utilize an 
nt/server platform, the 
irements by 
 software) provide the most secure environment for the 
cure 
 
to provide a fully 
hnology for both hardware and software. 
Empower uses a component-based architecture to allow seamless division of the 
4. Empower (and Millennium32 software) are the only data system to provide a fully 
scalable architecture. By being able to scale up, Empower Personal workstation 
customers are able to expand to the Enterprise architecture without loss of investment 
while maintaining the same user interface. By being able to scale down, Empower 
Enterprise customers are able to maximize system uptime. 
5. Empower Enterprise extends the capability of the Empower Personal workstation 
and Workgroup products across a laboratory or enterprise. 
 Empower Unique? 
1. Empower (and Millennium32 software) are the only data sy
integrated, relational database. With the Enterprise clie
centralization of the database minimizes system management requ
allowing access to all information from a central location. 
2. Empower (and Millennium32
storage of information. Information that is not stored in an isolated, se
environment is open to tampering, either deliberately or accidentally. 
3. Empower (and Millennium32 software) are the only data systems 
optimized implementation of client/server tec
application across multiple computers. 
 Empower Functionality 
1 Mu
re allows the user to choose the software interface that is appropriate for 
1. Pro – provides a look and feel that is similar to Millennium32 software; for Empower 
s samples on the fly. 
ts. 
erface that optimizes access to available 
functionality. Everything required to run samples and get answers is located in one 
place. Takes the software’s performance features and makes then as accessible to 
the occasional user as they are to the everyday user. 
Cent
 
ltiple User Interfaces 
The Empower Softwa
their individual requirements. 
users, system administrators and compliance managers. 
2. Open Access – for walkup users that need to run and proces
Results can be emailed to appropriate individual(s). 
3. Web – read-only access to data being acquired and processed resul
4. QuickStart – simple, single window int
ral Database 
Features Benefits 
One central database supports multiple Minimized system management and simpler 
data archival. Each system management task 
needs to be done only once. 
chromatography informati reports across labs, instruments and projects 
without concern for where the data was 
acquired or processed. The user does not need 
to search for information in more than one 
place. 
 from 
multiple instruments, laboratories and 
sites easily. 
Productivity is enhanced when information 
can be shared easily. Laboratories can pass 
methods and information electronically. 
Different sites can work with all the 
information across an enterprise without 
needing to worry about where the 
information is stored. 
(GLP/GMP/ER/ES) stored with results. Nothing is overwritten 
and all versions are available for review. 
Audit trails allow traceability and proof of 
modification or deletion. Specific features 
have been implemented to allo
clients running the Empower 
application. 
One central location for all 
on 
The user can create combined summary 
Access and share information
Assistance with regulatory compliance All method information and raw data is 
w compliance 
with ER/ES (21 CRF Part 11) for customers 
who must comply with FDA regulations. 
Interact with the system where it is 
appropriate and convenient for the 
user. 
Access any information on the system from 
any client computer. Work can be done 
where it is most convenient. Laboratory 
space can be utilized for instrumentswithout 
needing to use valuable bench space for 
computers/clients. 
 1-2 Waters Corporation 
 Empower Functionality 
1 Security & Regulatory Compliance 
 
 
Features Benefits
ecurity. Ensures that only valid 
do. 
tronic Full compliance with the ER/
pharmaceutical laboratories meet their 
obligations to the regula
d Result All information (excluding the raw 
data) 
without authorization. Any changes to 
this information can be audit trailed to 
ensure traceability 
• Access to ra
to modify or delete raw data except 
by using the Waters Service, and 
then only if authorized and their 
actions can be audit trailed. 
• Raw data integrity algorithms 
assess data each time it is fetched 
to determine if 
or intentionally. If the data is 
found to me modified from its 
original contents, the 
chromatogram is not displayed and 
en error is sent to the Message 
Center. 
om the On an Enterprise c
 
Empower user levels and logon s users are able to 
access the system and that each user can 
do only what they should be allowed to 
Electronic Record (ER) and Elec
Signature (ES) compliant-ready 
ES rule of 
the FDA (21 CRF Part 11) ensures that 
tory authorities. 
Fully Secure Sample, Method an
information is stored in the database. Users do 
not have access to this information 
Fully Secure Raw Data w data is controlled by 
the Waters Service. No user is able 
the data has been 
tampered with; either accidentally 
Information is stored remotely fr
user 
lient/server system, 
information is not stored on the local 
hard disk where the user can interact 
with it using the operating system. The 
information is stored on a remote, 
secure server, with the remote user only 
having access using all of security of 
the Windows 2000 or Windows XP 
operating systems and Empower. 
 
 
 1-3 Waters Corporation 
 Empower Functionality 
1 Component-Based Architecture 
 
Features Benefits
een Traditional workstation or LAN-based 
implementations of data systems burden 
one of the system components more than 
the others. This results in performance 
that changes dramatically as the load on 
the system changes. By optimizing the 
load on each co
improved and remains essentially 
constant under different
 and The server can be configured to allow 
the database to operate optimally. There 
does not need to be a compromise to the 
co
The server can be upgraded without 
impacting on the other system 
components. 
ed and 
sition 
The LAC/E32 can be configured to 
allow acquisition to op
compromise to the configuration to 
allow user interaction. More systems 
can be run on a LAC/E32 than can be 
run on a client, minimizing the cost of 
acquisition. 
med Processing is done on the client when 
the user wants to interact with the data 
or reprocess previousl
 
Application load is balanced betw
hardware components. 
mponent of the Empower 
Enterprise system, performance is 
 loads. 
Database operations are isolated
optimized on the server. 
nfiguration to allow user interaction, 
acquisition or other applications to run. 
Acquisition operations are isolat
optimized on the LAC/E32 acqui
server. 
erate optimally. 
There does not need to be a 
Processing operations are perfor
where it is most appropriate. 
y acquired 
information. During normal “run & 
report” while acquiring, processing is 
done on the LAC/E32 . This leaves the 
most processing power available at the 
client. The client can be logged out or 
even turned off and acquisition, 
processing and online reporting can 
continue. 
 
 
 
 
 1-4 Waters Corporation 
 Empower Functionality 
1 Scalable Architecture 
 
Features Benefits
al 
erver. 
Using the component-based architecture 
of Empower, customers can choose 
whichever configuration is best for 
them. Later they can scale up to an 
Enterprise system without needing to 
obsolete or trade-in any software or 
hardware. No r
With traditional data systems, if one 
component fails, the system is 
unavailable until the faulty component is 
repaired. With an Empower Enterprise 
system, if one component fails, an 
alternate component can be brought 
online to ensure th
 
Seamlessly scale up from Person
workstation to Enterprise client/s
etraining is required. 
Minimize downtime. 
at downtime is 
minimized and samples can continue to 
be run. If the server fails, store data in a 
local database. If an acquisition server 
fails, perform acquisition locally. 
 
 1-5 Waters Corporation 
 Empower Functionality 
1 
Empower Scalability Strategy 
Empower is an information management strategy for chromatography data. 
 
Empower is 
 
System SuitabilityMethod Development 
 
 
 
 
a family of products or a technology, it is not just a piece of software. It comprises: 
2. A series of add-on applications from Waters to enhance functionality 
 industry standard platforms 
4. The Toolkit, a recognition that Waters cannot meet all the demands of the 
customers. 
5. A series of partner applications to round out the functionality and make Empower a 
true laboratory solution 
 
 
 
 
 Simulated Distillation 
Structure Searches 
Other... 
Dissolution 
Pattern Matching
LC/MS 
GPC / GPCV 
Platforms 
2000 
indows 
XP 
Empower Applications 
Environment 
Elements: 
•Database
•Reporting
•HPLC
•Control
•Customization 
•GC
T 
o 
o 
l 
k 
I 
t 
LIMS 
Content Uniformity 
 •Windows • W
 
Other... 
1. A base set of features (the application environment) 
3. Availability on
1-6 Waters Corporation 
 Empower Functionality 
1 es a single 
re of the software gives you the flexibility to create a wide variety 
of configurations to meet different business needs. 
In a Persona rsonal workstation 
systems you ility but you also want to reduce the 
cost. To get the best availability, it is ideal to have one system per workstation and, as you add more 
systems, you add more workstations. 
 
Note that the different software components in the following diagrams are abbreviated 
Empower software is comprised of 3 software components that work together. The user se
application but the component-based natu
 
& Reporting 
 
Acquisition 
& Control 
Processing 
Database 
l workstation, all components are present in the same PC. However, with Pe
 must make a decision - you want convenience and availab
to a single letter, P=Processing, D=Database and A=Acquisition. 
 
 
 
 
 
 
 
 
 
 
 
A
D
P
 
A
D
P
 
P
 
 1-7 
A
D
Waters Corporation 
 Empower Functionality 
1 
To minimize cost, multi-system Personal workstations are available. The issue is that this strategy can 
compro ise the availability of the systems and the software due to the limited number of keyboards. 
 
 
 
 
 
So, what can be done? Must there be a compromise an
One option is to add processing stations where users c
keyboards without the cost of the acquisition compone
 
 
 
 
 
 
 
 
 
m
 
 
P
 
 
A
D
P
 1-
d a less than optimal solution? 
ould work to do data reduction. This added more 
nt. 
A
D
 
P
D
8 Waters Corporation 
 Empower Functionality 
1 only meant that 
 or network, it also meant there were multiple copies of 
er; all can 
it to the number of LAC/E acquisition servers 
you can use. There is no manual transfer of data and only a single copy of data is required. This is a good 
solution ere the laboratory already has one or more workstations. 
 
 
 
 
Empow Workgroup provides a tru
‘hub of t e wheel’. It is important th
with anything that can be done some
to accom lish business requirements
components are. 
 
 
 
 
 
The problem has always been ‘how does the data get to the processing station’? This not 
the data had to be manually moved via floppy disk
the data created. This solution has had limited applicability. 
Empower Workgroup solves this problem. A maximum of four clients can be used togeth
perform processing and data acquisition. There is no lim 32
 wh
 
P P
 
Ethernet
er
hp
 
e multi-user, m
at the LAC/E3
where else. N
, without the u
A
D
ulti-keyboard solution with the LAC/E32 module as the 
2 can also process data so that the PC is not burdened 
ote how the building blocks are now being moved around 
ser needing to worry about where the different 
D
 
1-9 Waters Corporation 
 Empower Functionality 
1 
Extending Empowe eates an Enterprise system, which is a full-scale client/server
configu n be scaled to any number of instruments an
across a laborato tire enterprise. There is no magic to client/server - it is just ano
configure Empow ratories can be added at any time, and processing stations c
where they are best utilized rather than needing to be with the instruments. 
 
 
 
A
r Workgroup cr
ry, site, or an en
er. Additional labo
P
 
 
 
 
D
P
P
ration. The Empower Enterprise solution ca
 1-10 Waters
P
LAC/E32
 
d users 
ther way to 
an be put 
 Corporation 
 Empower Functionality 
 
 1-11 Waters Corporation 
1 
 
 
 
 
 
 Empower Functionality 
1 
f you know that 
om the beginning 
mponents and that 
ompany can offer this and it gives great comfort to the user - 
knowing they do not have to accurately predict where they will be in several years and knowing that the 
 if you have a 
! If the only database resided on the server then samples could 
not be run until it was fixed. But, with the scalability of Empower, some clients can also have a database 
ain, the 
isition capability. 
ard workstations. 
eal to a business. Uptime is paramount in the modern 
laboratory and allowing this dynamic reconfiguration gives the system administrator the flexibility and 
peace of mind that they cannot get with any other package. 
This is the real message of Empower and scalability. 
So, no matter how a laboratory needs to grow, there is a configuration that makes sense. I
one day the lab would like to have an Enterprise system, you can head toward that goal fr
- knowing that any investment is protected, that scaling up is just the addition of new co
no retraining will be needed. No other c
strategy adapts to their changing circumstances. 
The scalability is also two way - scaling down is sometimes a good idea...what happens
client/server system and……the server fails
and, if the server is unavailable, you run samples locally. When the server is available ag
information is merged back into the central database. 
But, what if the entire network is down? In that case some clients can also include acqu
Now everything can continue as if you had stand
The concept is simple but it means a great d
 1-12 Waters Corporation 
 Empower Functionality 
2 
Section 2 - Technology 
Licenses & Key Disks 
Empower u re options, respectively. 
 
Note: With Empower, no site-wide licenses are available. All licenses, options and key 
tilizes licenses key disks to activate named user licenses and softwa
disks are specific to a single database (Personal workstation, Workgroup or 
Enterprise). 
The vari as follows: 
 
Named User License Key Disks 
 
licensing 
Empower 
se). Each named user must have a license whether they are logged into 
Empower or not. An Empower user can have a status of “Active”, “Disabled” or “Removed”. 
th a status of "Active" 
amed User Licenses 
d also does not 
orkgroup and 
he base 
(key disks) to 
nsing does allow 
ient software on any number of computers. 
r database, will 
ed. These license 
 100 users to be 
it is reached, you must 
 user accounts as 
Named User Licenses may be removed (uninstalled) from one database so that they can be 
transferred to another. You must ensure that you do not have more "Active" accounts than 
licenses when this occurs. You can do this simply by flagging accounts as "Removed" until 
they are within their license limits. If the number of active accounts exceeds the number of 
licenses because licenses have been removed, the next time a login occurs, the license 
violation will be detected and all non-Administrator accounts will be marked as "Removed". 
A system administrator will then need to activate accounts up to your license limit to allow 
users access to the system. 
 
ous types of licenses and options available, with information on their use is 
Named User Licensing is used in Empower. Named user licensing is an easy 
scheme to understand and implement. 
A named user is defined by Waters as any individual person who can access the 
software (the databa
A Named User is defined in Empower as any Empower user account wi
or "Disabled". "Removed" accounts do not count against the number of N
available to you. In addition, the "SYSTEM" account is a special account an
use a Named User License. 
Named user licensing applies to all Empower configurations - Personal, W
Enterprise. All configurations are supplied with 5 Named User Licenses in t
configuration. You may then purchase any additional Named User Licenses 
configure the system for the required number of analysts. Named User Lice
you to load the Empower cl
Named User Key Disks are floppy disks that, when installed to a Empowe
allow additional active user accounts to be created, up to the number install
key disks are available in a number of sizes, enabling 1, 5, 10, 15, 20, 50 or
enabled with a single disk. To create a new user account once that lim
either purchase more Named User Licenses or they must flag one (or more)
"Removed" to free existing licenses. 
 2-1 Waters Corporation 
 Empower Functionality 
2 base. While the 
tabase. If you 
e key disks can be 
alled on another. Key disks do not need to be 
uninstalled in any specific order. Each key disk will uninstall exactly the number of named 
icenses that were loaded from it in the first place. 
Ba
 
orkgroup vs. 
Enterprise) to be configured and sold. One of these key disks is required for every platform 
and, when loaded, defines the type of platform. This key disk must be uninstalled if the 
 
ersonal will also activate 5 named user licenses on the 
Named User License Key Disks, when loaded, place a token into the data
token remains in the database, the key disk cannot be loaded into another da
have more than one database available (multiple servers or instances) thes
uninstalled from one database and then inst
user l
se Key Disks 
This type of key disk allows different types of platforms (Personal vs. W
system is to be reloaded. 
The base key disk for Empower P
system where it is installed. The base key disk for Workgroup or Enterprise will not 
activate any named user licenses – each Workgroup or Enterprise installation will 
include at least one 5 named user key disk. 
ent/Server and Workstation Specific Option Disks 
Most option disks are specific to the type of system on which they will b
Cli
 
e loaded, Personal, 
Workgroup or Enterprise. An Enterprise option disk will not operate on a Personal 
, System Suitability, GPC, 
GPCV, Toolkit, Pattern Matching, Open Access, LIMS Interface, Chemical Structures, 
 Dissolution) enable the specified software 
(Personal workstation, Workgroup or Enterprise as appropriate). 
er. 
iring Key Disks 
 
ption disks. The software option is 
always enabled on each database as the appropriate detector is required to acquire this type of 
ccess options also do not require key disks. 
workstation, and vice versa. Software option disks (e.g. GC
Agilent 1100, Light Scattering, AutoArchive and
option for one database 
These option disks must be uninstalled if the data system is to be reloaded. 
Millennium32 option key disks will not function in Empow
Options Not Requ
Detector option disks (e.g. PDA and MS) do not require o
data. The Web and Open A
The Wate
y concerns and 
minimizes the administration required for acquisition server modules. 
O rvice is enabled: 
 
1. DCOM does not need to be configured on acquisition servers, minimizing setup 
time. 
2. No domain account is required by Empower, minimizingsecurity concerns. 
3. Autologon is not required on any acquisition servers, minimizing setup time and 
security concerns. 
rs Service 
The Waters Service is a Windows service that eliminates data securit
 
nce the Waters Se
 2-2 Waters Corporation 
 Empower Functionality 
2 users having read 
y privilege to the location where raw data files are stored, minimizing security 
e used on the server and any clients. 
4. The hidden file share used for raw data storage is secure, with all
onl
issues. 
Note: The Waters Service will b
How Operating System (OS) Security Works 
 
Every OS process runs on behalf of an account. Each account is identified internally by
Identifier (SID) and has an associated set of privileges. A particularly useful account is 
system account has unlimited priv
 a Security 
“System”. The 
ileges on the local machine, but has no access to network resources 
(except as described later). It cannot be disable, deleted, or modified. It cannot be used interactively (i.e. 
It is 
ect specifies which accounts are allowed to access it and what those accounts are allowed to 
e want to allow the 
low other accounts 
chine. It isn’t 
ng Server 
ocess on one machine tried to read a file on another machine, it wouldn’t be allowed to (even if the file 
were shared to “Everyone”). The Processing Server’s SID is considered to be the NULL SID on the remote 
machine, and connections are considered to be NULL Sessions. Fortunately, a registry entry allows a share 
on a machine to be specified as a “NullSessionShare” thus allowing System accounts on other machines to 
access it. The Share itself should continue to be named Waters_Projects$. 
 
cannot access the screen, mouse, etc.). It does not have a password since one does not log onto it. 
intended mainly for running OS services. 
 
Every OS obj
do to it. In our case, the objects we’re interested in are Shares, Directories, and Files. W
local System account full control over the raw data share, directories, and files; but al
only to read them. 
 
As stated earlier, the System account on one machine cannot access objects on another ma
even considered part of the domain’s “Everyone” group. So, for example, when a Processi
pr
 2-3 Waters Corporation 
 Empower Functionality 
2 How Operating System (OS) Services Work 
 
M). The code 
 Executable (.EXE) file and must be properly registered so the SCM knows about it (it will 
appear in the NT Services utility and so forth). The SCM starts the service by calling the EXE’s main entry 
tersService implements file and COM services. These are independent and could have been 
ters Service 
hese facilities, the Waters Service application launches the InstSrv application 
when it starts. Since a service can be configured to start automatically at machine bootup, and since InstSrv 
, this time consuming operation will usually be complete before the first 
Services are special OS processes that are started by the OS Service Control Manager (SC
exists as an
point. 
The Wa
implemented as separate service but, for simplicity, they are packaged in the single Wa
application. 
 
In addition to providing t
boots the busLAC/E if necessary
user tries to access instruments. 
 
Data Acquisition and Buffering 
On an Empower acquisition server (LAC/E or acquisition client), two processes (INST
CHROMSRV) are responsible for data acquisition and control. When the acquisition se
INSTSRV is started. INSTSRV then starts one CHROMSRV process for each configured
on the acquisition server. Each CHROMSRV is dedicated to a particular chromatographic
 
32 SRV and 
rver is booted, 
, on-line system 
 system. 
When an Empower chromatographic system (the CHROMSRV application) acquires data destined for a 
cludes data 
romatogram data 
 copy is deleted. 
If CHROMSRV is unable to transfer data to Oracle or copy files to the server, it continues to run but no 
 be written locally 
until the next 
h connection to the 
o the database and will come out of buffering mode, 
continuing operation as normal. If it fails to connect, the set continues but is run in “buffering mode”. 
Every 10 minutes (approximately) after the end of the sample set (assuming buffering is still in progress) 
on in need of 
ful, it transfers 
oper directory 
 
s are Recognized 
 
CHROMSRV uses the normal Empower calls to store Sample Sets, Injections, Chromatograms and so forth 
in the database. When one of these fails, as would be the case when Oracle is not reachable, the call returns 
an error. If CHROMSRV sees an error, it goes into “buffering mode”. CHROMSRV likewise uses 
Empower calls to write and copy files. These in turn use the underlying Microsoft file routines. So if one of 
these Microsoft routines were to report a failure, CHROMSRV would also go into “buffering mode”. 
 
Local Directory and File Organization 
 
database on another machine in the network, it first writes the data locally to files. This in
destined for Oracle, and the chromatogram data files. As each injection completes, the ch
files for that injection are copied to the database server and, if the copy succeeds, the local
At the successful end of a sample set, the file containing the Oracle data is also deleted. 
 
longer attempts to converse with Oracle or the server’s data directory. Data continues to
to files. CHROMSRV is said to be in “buffering mode”. It remains in “buffering mode” 
sample injection. Before the next injection is done, CHROMSRV attempts to re-establis
database and, if successful, will send all buffered data t
 
INSTSRV examines the directory of local files and, if it finds a sample set or single injecti
recovery, tries to connect to the appropriate server and project. If the connection is success
the Oracle data from the local file to the remote Oracle, and copies local data files to the pr
on the server. If the copy is successful the local copies are deleted. 
How Oracle and Server Failure
 2-4 Waters Corporation 
 Empower Functionality 
2 corresponding 
xxxx.dat where the 
an be found in a 
is in turn organized 
llowing file 
ySystem” is acquiring data destined for server “MyServer” and project 
“MyProject”. If Oracle were currently reachable you would see a Sample Set with identifier 1234 in the 
A similar technique is used for single injections, but an empty file named Singlexxxx.dat is used in place of 
 indicates that there is a matching Dxxxx.dat file being acquired or in 
need of recovery. 
de directly to Oracle 
he identifier assigned by Oracle is used. These tend to be large numbers (identifiers start at 1000). If 
Oracle is not reachable, CHROMSRV assigns a local identifier by simply incrementing a counter that starts 
 recovery, 
for, and assign actual identifiers to, items it had to identify 
locally. 
 
The timestamps used for injections use the same technique – if Oracle is reachable then Oracle’s data/time 
is used. If not, the local machine’s date/time is used. 
The Oracle destined data is kept in a file named SampSetxxxx.dat where xxxx is a number
to the Sample Set’s Identifier in Oracle. The chromatogram data is kept in files named D
xxxx likewise corresponds to the Oracle channel (chromatogram) identifier. These files c
directory named Empower\InstrumentServer on the acquisition server. This directory 
into subdirectories organized by System, Database Server, and Project. So, for example, the fo
would indicate that System “M
Project application’s Sample Set view. 
 
\Empower\InstrumentServer\MySystem\MyServer\MyProject\SampSet1234.dat 
 
SampSetxxxx.dat. The file simply
 
How Identifiers are Assigned 
 
If Oracle is reachable, the Oracle entries for Sample Sets and Chromatograms are ma
and t
at 1. In other words, these files have low numbers like SampSet4.dat and D12.dat. During
CHROMSRV asks Oracle to make entries 
 2-5 Waters Corporation 
 Empower Functionality 
2 
Empower & Date Handling 
 and date handling 
 all date arithmetic and comparison using 
n other words,there 
cified via the 
l Panel settings. So a user could, for example, choose a date format that represented the 
year as 2 digits. In this case, a year of “00” could appear on the screen or in a report. But again, that’s not 
tion would change 
 filters. Filters 
eans “dates 
efaults 2 
en after the turn of the Millennium, this filter would still work as 
en Oracle releases new versions after the year 2000, they will probably change to a 
century default of “20”. If the do this, in this example, the view filter would not show new rows (i.e. rows 
e problem by 
at 
d second. This 
 with 1 second 
Microsoft Date Format 
 
Microsoft represents dates using an 8 byte floating point number with December 30 1899 at midnight being 
the number 0.00. So, for example, January 4, 1900 at noon is internally represented as the floating point 
number 5.50. This format and related Microsoft routines support dates ranging from January 1, 100 to 
December 31, 9999 with an approximate resolution of 1 millisecond. 
 
How Empower Handles Dates 
 
Empower internally stores and operates on dates using Oracle and Microsoft date formats
routines. These formats are summarized below. Empower does
these internal formats, so the number of digits used to display the year are irrelevant. I
should be no year 2000 problem (the year 4713, however, is another story). 
 
Dates are formatted and displayed using Microsoft formatting routines. The format is spe
Microsoft Contro
what is stored or computed with. Changing the control panel to a 4 digit date representa
the display to “2000”. 
 
The one place where date formats can cause unexpected behavior is in user specified view
can be specified to select dates before or after a specified one. For example, “>3/3/97 “ m
greater than March 3, 1997”. Empower uses the Oracle conventions in view filters, and Oracle d
digit years to the century “19”. So ev
expected. However, wh
with years like 00, 01, ..). The actual data is still stored properly, and a user can remedy th
specifying a 4 digit date in the view filter. 
 
Oracle Date Form
 
Oracle represents dates using one byte each for century, year, month, day, hour, minute an
format supports dates ranging from January 1, 4712 BC through December 31, 4712 AD
resolution. 
 
 2-6 Waters Corporation 
 Empower Functionality 
2 Where Do The Dates Come From? 
nterprise environment 
(on a Personal workstation everything is based on the local PC clock). Note that a client in this case is 
either a p ing client or an acquisition 32 ). 
 
 
The following table shows the place of origin of Empower dates in a Workgroup or E
rocess server (eg.LAC/E
Item eratio
Date Acq t 
Date Processed 
Date Cali
Sample Set S t 
Sample Set F t 
Result Set Date 
Library C
Method Create
Current Date (
Sign Off Dat
Sign Off Date 2 
Normal Op n Buffering Mode Note
uired Server Clien 1,4 
Server N/A 
brated Server N/A 
tart Date Server Clien 4 
inish Date Server Clien 4 
 Server N/A 
reate Date Server N/A 
 Date Server N/A 
Report) Client N/A 2,4 
e 1 Client N/A 4 
Client N/A 4 
Data File Create Date 
(DXXXX.DAT) 
Server Server 3 
Project Create Date Server N/A 
Project Last Archived Date Client N/A 
otes: 
4 
 
N
 
ommunication with 
quisition of a 
e on the server. In this case the local client internal clock 
e the system is 
ate to the database 
clock. 
aced onto the 
nd time. Since the file may be placed on the 
server some time after acquisition is complete when in buffering mode, the "Date 
Acquired" field and the data file creation date may not be similar. This is normal 
behavior when buffering has occurred. 
4. The Client clock can easily and automatically be synchronized with a time server on 
the network. This will ensure that the same time is reported for both the server and 
the client, avoiding any confusion over time stamps. 
1. When Empower is buffering data acquisition (due to a loss of c
the server) there is the potential for a lengthy delay between the ac
sample and its later storag
is used to determine Date Acquired. 
2. The system create date must be the client internal clock date sinc
created by the InstSrv process. This process does not communic
so must use the local internal 
3. The data file creation date is the date at which the data file was pl
server hard disk and is the system date a
 2-7 Waters Corporation 
 Empower Functionality 
2 
Empower Use of Oracle Tablespaces 
ation. This 
additional IT 
mpower) to be an 
mer has little or no 
 Oracle database exists in the application. Waters does not grant an Oracle license -- 
tribution 
ogram administration 
 enabling centralized and remote administration and by including 
inistration scripts including startup, shutdown, and 
back addition, all support for 
prog
) 
Emp System Installation and Configuration Guide 0312 on A) 
 organiz spaces”. Oracle allows a tabl e to occupy multiple 
files, but f a single file per tab e. These tablespaces / files are: 
Empower Software contains an Oracle database, which is fully integrated into the applic
approach was designed to offer enterprise grade Oracle technology without requiring 
resources to manage it. Oracle considers an Embedded License Application (such as E
application where the database is truly embedded into the application and the custo
knowledge that the
rather Waters grants to Empower users the use of its Oracle license under a sub-license dis
agreement with Oracle. 
The Empower application has been designed and developed by Waters to eliminate pr
tasks by the customer. This is done by
built in program administration functions. All adm
up are provided by Waters and reside within the application program. In
ram operations are provided by Waters. 
Additional information is located in the following documents: 
 - Empower Software System Administrator’s Guide (71500031708, Revision A
 - ower (71500 07, Revisi
Oracle es data in logical units called “Table espac
disk or simplicity Empower uses only lespac
 
Tablespace File Initial Maximum 
System \Empower\Ora\Database\System01.dbf 50 250 
Project \Empower\Ora\Database\Usr1Wat3.dbf 100 
Undo \Empower\Ora
1000 
\Database\Undo01.dbf 10 250 
Index \Empower\Ora\Database\Idx1Wat3.dbf 10 150 
Temporary \Empower\Ora\Database\Tmp1Wat3.dbf N/A 
 
The initial size of these tablespaces 
N/A 
is determined by the Empower Installer and is based on the type of 
specified 
hen the sort is 
 down, but never (so 
 items, it enforces the concept of a “Transaction”. A transaction is something 
that either runs to completion or not at all. So, for example, when you store a result with 10 peaks, either all 
 turned off after 
 if in never happened 
e undone. Oracle 
ary tablespace, 
orage used goes up and down because Oracle can free the storage once the transaction is 
complete. It should rarely be necessary to change the Undo tablespace settings. These should not be 
changed unless Oracle reports errors. 
 
Oracle uses the System Tablespace to remember which tablespaces, tables, projects, indexes and so forth it 
is managing. The actual data for these items (projects for example) is stored in other tablespaces, but 
information about the items is stored here. It is unlikely that there will be a need to change the System 
Tablespace settings. In a very large installation with hundreds of projects, the user may get an Oracle error 
complaining about System tablespace when they try to create or restore a project. Only then should the 
settings be changed. 
configuration. As tablespace is used up, Oracle will automatically extend the size of a file by a 
increment up to the specified maximum size. 
Oracle uses the Temporary tablespace to sort rows and do other internal housekeeping. W
complete, Oracle frees the storage. The amount of temporary storage used goes up and
far) exceeds the maximum allowed file size. 
 
When Oracle adds or removes
10 peaks are stored, or none at all. This is true, for example, even if the system’spower is
storing 3 of the 10 peaks. When Oracle starts up, it will “roll back” the transaction as
In order to enforce a transaction, Oracle must keep track of what it is doing so it can b
does this in Rollback Segments that reside in the Undo Tablespace. Much like the tempor
the amount of st
 2-8 Waters Corporation 
 Empower Functionality 
2 mple, when the 
r if it has an index 
u know their 
omeone’s name 
mount of Index 
. As new items are 
ct, Oracle adds new indexes for them. The system administrator should occasionally check 
it up to the 
tion to Project data, 
wer users, groups, systems, and so 
forth. Note that the raw chromatogram files themselves are not stored in Oracle, they’re kept in files outside 
ace is used, but 
all projects use as they need. The 
tablespace number you enter when creating a project, or see when you view project properties is simply a 
quota. Its only purpose is to keep a project from using up an unfair amount of the project tablespace. There 
ge price to be paid for changing it or for making it large initially. You don’t pay 
 
Oracle uses the Index Tablespace to cross-index tables to improve performance. For exa
user wants to see all the peaks from a particular result Oracle can find them much faste
relating peaks to results. This is analogous to looking up someone’s phone number. If yo
name, it’s easy to find the number because a phone book is indexed by name. Finding s
given his or her number is much harder because you have to search the entire book. The a
tablespace used should be roughly proportional the amount of Project tablespace used
added to a proje
how much Index tablespace is used, but remember that Oracle will automatically increase 
specified maximum. 
 
Finally there is the Project Tablespace. This is somewhat of a misnomer because in addi
it also contains library and spectral data and information about Empo
of Oracle. The system administrator should occasionally check how much Project tablesp
remember that Oracle will automatically increase it up to the specified maximum. 
 
There is one large Project Tablespace file named Usr1Wat3.dbf that 
is no performance or stora
until you actually use the storage. Think of it as a credit limit on your charge card. 
 
Application Components 
 components, a Processing server, an 
Acquisition server and the Oracle Database server. Many different Empower executable files communicate 
with these components, on the same or difference machines, to present the Empower application to the 
user. 
The different components and applications are shown in the diagram below: 
 
Communication between the Empower
database server uses COM when the co
components are remote (on different m
Empower uses a component-based architecture with three main
Empower Executables
 
 executables, processing server, acquisition server and Oracle 
mponents are within the same machine, and DCOM when the 
achines). 
Network Interface Card
TCP/IP
Windows Operating System
Oracle TNS Listener
Oracle Database Server
Acquisition Server
Processing Server
Oracle 9i
2-9 Waters Corporation 
 Empower Functionality 
2 (for example when processing a sample), the communication between the client and 
the server is as shown below: 
When accessing raw data fi
communication between th
standard operating system c
the raw data file was succes
 
During database access
 
Empower Executables
Empower ‘Servers’ 
Instrument Server
An Instrument Server contr
observe and control instrum
injections. It saves acquired
may transfer these chromat
Processing Server to proces
Processing Server if it can c
 
 
 The major services it provi
 
 
les (for example when writing the data file after acquisition), the 
e client and the server is as shown below. In this case, communication uses 
alls to send and receive raw data. TCP/IP security is used to determine whether 
sfully delivered to the client or the server (as appropriate). 
Client Server
Network Interface Card
TCP/IP
Windows Operating System
Oracle 9i
Oracle TNS Listener
Acquisition Server
Processing Server
Network Interface Card
TCP/IP
Windows Operating System
Oracle 9i
Oracle TNS Listener
Oracle Database Server
Client Server 
Network Interface Card
TCP/IP
Windows Operating System
Oracle 9i
Oracle TNS Listener
Acquisition Server
Processing Server
Empower Executables
Network Interface Card
TCP/IP
Windows Operating System
Oracle 9i
Oracle TNS Listener
Oracle Database Server
 
ols a single chromatography system. An instrument server allows clients to 
ents that make up the system. It can carry out a single injection or a sequence of 
 chromatograms locally via a local Storage Server. In some configurations, it 
ograms to a remote Storage Server at the end of each injection. It may ask the 
s and report on each injection’s worth of chromatograms. It may also ask the 
ontinue with the next injection (e.g. interactive suitability, “must peak”, etc...). 
des are: 
2-10 Waters Corporation 
 Empower Functionality 
2 
• Get configuration information (head sizes, options installed, etc...) 
s (current temperatures, flows, states, etc...) 
nts per a specified Instrument Method. 
• Run a sample set’s worth of injections 
• Configure a system out of modular instruments (legacy only) 
Interactively control instruments (auto zero, run diagnostics, etc..) 
s of objects. An Instrument Server fetches 
Instrument M t ets from a Storage Server and stores Chromatograms to a Database 
Server. Objects can be transferred by fetching from one database server and storing to another. 
 
The following objects are standardized for use by the Database Server: 
 
• Instrument Methods 
Chromatograms 
..) 
Processing Server 
A Processin rth of chromatograms to produce results and (optionally) 
reports. It ca so be asked to do special things like “Clear Calibration”. The Instrument Server asks it to 
do these thi . k whether, as a result of the processing, it should 
continue with the next injection or not. A third party application can “hook into” processing to compute the 
value of som c s. 
 
The major s i
 
• Process and Report on this Injection 
• Perform this Processing Function 
• OK to Continue ? 
• Hook processing (after results computed, but before reported) 
• Get instrument statu
• Get instrument real-time data 
• Set instrume
• Perform an injection 
• 
 
Database Server 
 
A Database Server stores and fetches certain standard type
e hods and Sample S
• Sample Sets 
• 
• Instrument history (total operating hours, last seal calibration, etc.
• Results (Toolkit Only) 
 
g Server processes an injection’s wo
n al
ngs The Instrument Server can also as
e ustom result field
erv ces it provides are: 
 2-11 Waters Corporation 
 Empower Functionality Version 4.0 
. . . . . 
3 
. .. . . 
ality Section 3 – Function
Def
ion present finitions of terms used in this document. Other terms are 
ned in contex document. 
initions 
This sect
explai
s acronyms and de
t through the 
 
Term Definition 
A line drawn from the start point of a peak to end po
needed to calculate peak area or peak heigh
Short-term fluctuations in a detector baseline sign
background electrical noise and other environment
interference keeps the baseline from being pe
The technique of running standards before and aft
interspersed with samples in a sample set to con
calibration curves. Each calibration curve is then
the concentration or amount of the sample ‘
standards. This te
chromatograph
evaporation that may occur during the course of i
samples. 
 run A set of standa
chromatographic experiment. 
European Pharmacopoeia 
 A method
peak by estimating the shape of the larger peak 
function. 
Japanese Pharmaco
peak area econds or equivalent) 
eak and end-of-peak points 
The detector response (reported in units of µV-s
integrated over time between the start-of-p
minus the baseline. 
The detector response (reported in units of µV or e
m
measured at the samerun time. 
peak name by the user to components eluting at a given The name assigned 
response time. 
The elution time of a component at the apex of the
A measure 
two components u
baseline int of peak – 
t. 
baseline noise al that are due to 
al variations. The 
rfectly flat. 
bracketing er and/or 
struct one or more 
 used to determine 
bracketed’ by the 
chnique can help to compensate for variations in 
y caused changes in temperature, flow, or solvent 
njecting a set of 
chromatographic rds and/or samples injected during the same 
EP 
exponential skim of resolving small rider or shoulder peaks from a larger 
using an exponential 
JP poeia 
peak height quivalent) 
easured between the apex of the peak and the baseline value 
 3-1 Waters Corporation 
retention time peak. 
selectivity of the relative retention on a chromatographic column of 
nder the same mobile phase and stationary phase 
conditions. 
sequence A set of standards and/or samples injected during the same 
chromatographic experiment. 
SOP Standard Operating Procedure 
tangential skim A method of resolving rider or shoulder peaks from a larger parent 
peak by drawing a (straight) line to tangentially skim the rider peak 
from the parent peak. 
USP United States Pharmacopoeia 
 
 
 Empower Functionality 
3 General 
Em
ted database 
ation. Empower 
ts into usable information 
omplete chromatography 
can adapt to your individual chromatography 
requirements by using as many or as few Empower software capabilities as you require. 
nal computer. It 
AC/E card interface and a local database that supports the Empower 
age 
ms to an 
 
m of four clients. 
s no limit to the number of LACE32 Acquisition Servers (a network device dedicated to 
ntrol and data acquisition) that can be configured. 
 
f the Empower 
• Empower Pro - provides access to all features of the Empower software. This interface is 
nnium32 users. 
 
ware required in an 
any infrequent/new users and/or ‘walkup’ users. 
• Empower QuickStart - provides a streamlined interface to the main features of Empower 
 with an emphasis on simplicity and ease of use. 
 
 
A Users can choose the interface 
to t interface is defined for each user, so that the user’s 
p to be explicitly chosen at each log in. 
 
 
power General Description 
Empower Software is a 32-bit data management platform with advanced integra
architecture. It acquires, processes, reports, and manages chromatographic inform
offers easy-to-use technology and converts high-quality, accurate resul
while meeting security and regulatory compliance requirements. It is a c
and results management system that you 
Empower is available in different configurations: 
• The Empower Personal workstation is a stand-alone, single-user perso
includes a busL
chromatography application software to acquire, process, report, and man
chromatographic information. You can connect up to four online HPLC syste
Empower workstation. 
• The Empower Workgroup is a small client/server system with a maximu
There i
chromatographic instrument co
• The Empower Enterprise system is a corporate-wide networked version o
workstation. 
 
Four different user interfaces are available: 
 
similar to that of Millennium32 and will therefore be familiar to Mille
• Empower Open Access - provides access to the features of Empower soft
environment for routine analysis, one with m
 
 
• Empower Web - provides simplified access to Empower software via a web browser. 
 
software
ll interfaces are supplied in the base Empower software package.
 log in to within the login dialog. A defaul
referred interface does not have
 Function 
 Empower is a 32-bit Microsoft Windows application. 
 Empower is available in English, Japanese, Chinese, and Korean versions. 
 Empower is based around an Oracle database. 
 No data is overwritten in the Empower database. 
 Using Empower software, you can: 
Acquire data and control chromatographic instrumentation 
Process data interactively or in the background 
 3-2 Waters Corporation 
 Empower Functionality 
3 oject information Customize management of pr
Customize report design and generation 
 Using Empower software y
 such as:
ou can easily perform simple acquisition and processing 
 
 single injection 
requirements
Making a
Processing data 
Printing a report 
Using Empower you
Interactively creating and acquiring sample sets 
Defining custom reports 
Performing tracking and t
 Empower development and testing follows a documented software devel
(SDL
opment lifecycle 
C). 
 Empower is ISO 9001 TickIT certified. 
 Comprehensive, context-sensitive Windows online help is supplied with the Empower 
application. 
 Waters maintains all development documentation, including Functional Specifications, 
ycle. Source Code, Test Protocols and other information related to product life c
 Source code for each version of Empower is available in an Escrow Account. 
 Automated qualification is available for Empower workstations, clients and acquisition 
servers. 
 Custom programs that interact with or control Empower may be written us
Toolkit. The Toolkit is a programming inte
ing the Empower 
rface to Empower functionality. 
 Multiple Toolkit applications may be run at the same time to execute different tasks. 
 The Toolkit supports any programming language that supports Microsoft standards such as 
eX and COM (for example: Visual Basic, VBA, Visual C++ etc.). Activ
The Toolkit a
menu items to various Emp
 can perform sophisticated applications such as: 
Creating and adding custom fields, and calculating custom database results 
rending of results using the Empower database 
 llows applications to be configured into the Empower user interface by adding 
ower windows as required. 
 The Empower LIMS Interface provides a seamless interface to LIMS systems. Specific 
LIMS systems/formats supported include: 
ASCII 
Systems LabManager LIMS 
AIA (ANDI) 
PE SQL*LIMS 
Lab
 
 
Installation, Configuration and System Management 
Co g
ation Manager is a graphical user interface that provides system management 
ons to control various parts of the Empower software. These functions include managing: 
• Project information 
• Custom fields 
• Acquisition servers (configuring local and network acquisition servers) 
• Chromatographic systems (creating and configuring local and network systems) 
• Spectral libraries 
• Library spectra 
• Users 
• User groups 
nfi uration Manager 
The Configur
functi
 3-3 Waters Corporation 
 Empower Functionality 
3 vileges 
dit Trail 
es for injections 
 
ies 
• Electronic Signatures 
• Electronic Records 
 
• User types and access pri
• The System/Project Au
• Plate typ
• Default strings
• System polic
 Function 
 Users with the appropriate privilege can remotely reboo 32t LAC/E acquisition servers. 
 The display of information can be customized with default or user-defined view filters to 
determine the fields, criteria, and the order in which data is displayed. 
 Configuration actions allow the use of standard drag-and-drop, display, selection, and cut-and-
paste code functions. 
 Configuration information is displayed in tabular format. Table columns can be sorted in 
ascending and descending order and tables can be printed. 
 All Empower objects selected may be deleted via a ‘Yes to All’ button added t
warning dialog, or t
o the delete 
he user will have the choice of deleting each object selected ‘Yes’ or ‘No’, 
or they may ‘Cancel’ all together. 
 Preferences can be copied between users and projects on a per-user and per-project basis. 
Preferences can be copied during project creation or using the View > Copy Preferences menu 
in Configuration Manager. 
 The ConnectionsAQT option (if present) is available from Configuration Manager. 
 The System Monitor application is available from Configuration Manager. 
 
P je
A information, and raw data 
th at reside in the Empower database under a single project name.