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17.17 17.18 Both groups are weakly activating, but the position ortho to the methyl group is less sterically hindered than the position ortho to the isopropyl group. The Friedel-Crafts acylation reaction is very sensitive to steric effects. 17.19 CH₂CH₃ a) b) no reaction c) OH CPh O O 0 d) e) 17.20 CH₃ OCH₃ O a) + b) + 253