<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg1.png"><div class="t m0 x1 h1 y1 ff1 fs0 fc0 sc0 ls0 ws0">Absorção de Fármacos </div><div class="t m0 x2 h2 y2 ff1 fs1 fc0 sc0 ls0 ws0"> </div><div class="t m0 x2 h3 y3 ff1 fs2 fc0 sc0 ls0 ws0"> </div><div class="t m0 x3 h4 y4 ff2 fs3 fc0 sc0 ls0 ws0">Passagem do fármaco do </div><div class="t m0 x4 h5 y5 ff2 fs0 fc0 sc0 ls0 ws0">local de administração </div><div class="t m0 x5 h4 y6 ff2 fs3 fc0 sc0 ls0 ws0">para a circulação </div><div class="t m0 x6 h5 y7 ff2 fs0 fc0 sc0 ls0 ws0">sanguínea </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg2.png"><div class="t m0 x1 h6 y8 ff1 fs4 fc1 sc0 ls0 ws0">Membrana Plasmática </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg3.png"><div class="t m0 x7 h3 y9 ff1 fs2 fc0 sc0 ls0 ws0">Fases de ação dos </div><div class="t m0 x8 h2 ya ff1 fs1 fc0 sc0 ls0 ws0">fármacos<span class="_0 blank"></span> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg4.png"><div class="t m0 x9 h7 yb ff1 fs5 fc1 sc0 ls0 ws0">Fator<span class="_1 blank"></span>es <span class="_2 blank"></span>que influenciam a </div><div class="t m0 xa h7 yc ff1 fs5 fc1 sc0 ls0 ws0">absorção <span class="_2 blank"></span>de fármacos<span class="_0 blank"></span> </div><div class="t m0 xb h8 yd ff2 fs5 fc0 sc0 ls0 ws0"> </div><div class="t m0 xc h9 ye ff1 fs6 fc0 sc0 ls1 ws1">A)<span class="ls0 ws0">Ligados <span class="_2 blank"></span>à via de administração </span></div><div class="t m0 xd h7 yf ff1 fs5 fc0 sc0 ls0 ws0">do fármaco<span class="ff2"> <span class="_2 blank"></span> </span></div><div class="t m0 xe ha y10 ff2 fs6 fc0 sc0 ls0 ws0"> </div><div class="t m0 xc h7 y11 ff1 fs5 fc0 sc0 ls2 ws2">B)<span class="ls0 ws0">Ligados <span class="_2 blank"></span>ao fármaco<span class="_0 blank"></span><span class="ff2"> <span class="_2 blank"></span> </span></span></div><div class="t m0 xe ha y12 ff2 fs6 fc0 sc0 ls0 ws0"> </div><div class="t m0 xc h7 y13 ff1 fs5 fc0 sc0 ls3 ws3">C)<span class="ls0 ws0">Ligados <span class="_2 blank"></span>ao organismo<span class="_0 blank"></span><span class="ff2"> </span></span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg5.png"><div class="t m0 xf hb y14 ff1 fs7 fc0 sc0 ls7 ws4">A)<span class="ls0 ws0">Ligados à via de<span class="_2 blank"></span> administração do </span></div><div class="t m0 x10 h6 y15 ff1 fs4 fc0 sc0 ls0 ws5">fármaco<span class="ff2 ws0"> </span></div><div class="t m0 xf hc y16 ff2 fs4 fc0 sc0 ls0 ws0"> </div><div class="t m0 xf hb y17 ff1 fs7 fc1 sc0 ls8 ws6">1) <span class="ls0 ws0">A<span class="_3 blank"></span> ár<span class="_1 blank"></span>ea da superfície<span class="ff2 ls4"> </span>absortiva<span class="_2 blank"></span> </span></div><div class="t m0 xf h6 y18 ff1 fs4 fc1 sc0 ls0 ws0"> </div><div class="t m0 xf h6 y19 ff3 fs4 fc0 sc0 ls5">\uf0d8<span class="ff1 ls0 ws0">superfície: absorção maior </span></div><div class="t m0 x11 hb y1a ff1 fs7 fc0 sc0 ls0 ws0"> Ex: <span class="ff2">epit<span class="_2 blank"></span>élio alveolar pulmonar e a </span></div><div class="t m0 x12 hc y1b ff2 fs4 fc0 sc0 ls0 ws0">mucosa intesti<span class="_2 blank"></span>nal </div><div class="t m0 x13 hc y1c ff2 fs4 fc0 sc0 ls0 ws0"> </div><div class="t m0 xf hd y1d ff3 fs7 fc0 sc0 ls6">\uf0d8<span class="ff2 ls0 ws0">Depende: vi<span class="_2 blank"></span>a de administração </span></div><div class="t m0 xf hc y1e ff2 fs4 fc0 sc0 ls0 ws0"> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg6.png"><div class="t m0 xf hb y14 ff1 fs7 fc0 sc0 ls7 ws4">A)<span class="ls0 ws0">Ligados à via de<span class="_2 blank"></span> administração do </span></div><div class="t m0 x10 h6 y15 ff1 fs4 fc0 sc0 ls0 ws5">fármaco<span class="ff2 ws0"> </span></div><div class="t m0 xf hc y16 ff2 fs4 fc0 sc0 ls0 ws0"> </div><div class="t m0 xf hb y17 ff1 fs7 fc1 sc0 ls0 ws7">2)<span class="fc0 ws0"> <span class="_3 blank"></span><span class="fc1">A<span class="_3 blank"></span> cir<span class="_1 blank"></span>culação <span class="lsa ws8">no</span> local <span class="lsa ws8">de</span> administração<span class="_2 blank"></span> </span></span></div><div class="t m0 xf h6 y18 ff1 fs4 fc1 sc0 ls0 ws0"> </div><div class="t m0 xf h6 y19 ff3 fs4 fc0 sc0 ls5">\uf0d8<span class="ff1 ls0 ws0">> <span class="_4 blank"> </span>fluxo <span class="_4 blank"> </span>sangüíneo:<span class="lsb"> </span>velocidade <span class="_4 blank"> </span><span class="lsc ws9">de</span> </span></div><div class="t m0 x10 hb y1a ff1 fs7 fc0 sc0 ls0 ws0">absorção <span class="lsa ws8">do</span> fármaco<span class="_2 blank"></span>. </div><div class="t m0 xf h6 y1b ff3 fs4 fc0 sc0 ls5">\uf0d8<span class="ff1 ls0 ws0">< <span class="_5 blank"> </span>fluxo <span class="_5 blank"> </span>sangüíneo:<span class="ls9"> </span>(r<span class="_1 blank"></span>etardar) </span></div><div class="t m0 x10 h6 y1c ff1 fs4 fc0 sc0 ls0 ws0">absorção. </div><div class="t m0 x10 hb y1d ff1 fs7 fc0 sc0 ls0 ws0"> </div><div class="t m0 xf h6 y1e ff3 fs4 fc0 sc0 ls5">\uf0d8<span class="ff1 ls8 wsa">Ex<span class="ls0 ws0">. músculo deltóide X glúteo </span></span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg7.png"><div class="t m0 x14 h6 y1f ff1 fs4 fc0 sc0 ls0 ws0">B) Ligados ao fármaco </div><div class="t m0 x14 he y20 ff2 fs8 fc0 sc0 ls0 ws0"> </div><div class="t m0 x14 h6 y21 ff1 fs4 fc1 sc0 ls0 ws0">1)<span class="_6 blank"> </span>Solubilidade <span class="_7 blank"> </span><span class="ls11 wsb">do</span> <span class="_7 blank"> </span>fármaco: <span class="_7 blank"> </span><span class="fs9 fc0">caracterizada<span class="_0 blank"></span> <span class="_8 blank"> </span>pelo </span></div><div class="t m0 x15 hf y22 ff1 fs9 fc0 sc0 ls0 ws0">coeficiente <span class="ls12 wsc">de</span> partição lipídeo/água<span class="_0 blank"> </span> </div><div class="t m0 x14 hf y23 ff1 fs9 fc2 sc0 ls0 ws0">Coeficiente <span class="_9 blank"> </span><span class="ls12 wsc">de</span> <span class="_9 blank"> </span>partição <span class="_9 blank"> </span>(<span class="ff4 wsd">K</span><span class="lsd">): <span class="_9 blank"> </span></span><span class="ff2 fc0">relação <span class="_9 blank"> </span>das <span class="_9 blank"> </span>concentrações <span class="_9 blank"> </span><span class="ls13 wse">da</span> </span></div><div class="t m0 x14 h10 y24 ff2 fs9 fc0 sc0 ls0 ws0">substância <span class="ls14 wsf">em<span class="_2 blank"></span><span class="ls0 ws0"> <span class="_0 blank"></span>óleo e <span class="ls14 wsf">em</span> água. </span></span></div><div class="t m0 x14 h11 y25 ff5 fsa fc2 sc1 lse">\uf0de<span class="ff2 fc0 sc0 ls0 ws0"> <span class="_8 blank"> </span>sistema <span class="_8 blank"> </span>com <span class="_8 blank"> </span>dois <span class="_8 blank"> </span>líquidos <span class="_8 blank"> </span>im<span class="_2 blank"></span>iscíveis <span class="_8 blank"> </span><span class="ff6">A<span class="_1 blank"></span> <span class="_8 blank"> </span>(éter<span class="_a blank"></span>, <span class="_8 blank"> </span>clor<span class="_1 blank"></span>ofór<span class="_2 blank"></span>mio <span class="_8 blank"> </span>= <span class="_8 blank"> </span>fase </span></span></div><div class="t m0 x14 h12 y26 ff6 fsb fc0 sc0 ls0 ws10">or<span class="_1 blank"></span>gânica)<span class="_2 blank"></span><span class="ff2 lsf ws0"> e<span class="_b blank"></span> <span class="ff6 ls0">B <span class="_c blank"> </span>(água <span class="_c blank"> </span>= <span class="_c blank"> </span>fase<span class="_0 blank"> </span> <span class="_c blank"> </span>aquosa)<span class="ff2">, <span class="_c blank"> </span>e <span class="_c blank"> </span>adicionarmos <span class="_c blank"> </span>uma <span class="_c blank"> </span>terceira </span></span></span></div><div class="t m0 x14 h12 y27 ff2 fsb fc0 sc0 ls0 ws0">substância (soluto), a substância <span class="lsc ws11">se</span> distribuirá diferentem<span class="_2 blank"></span>ente nas </div><div class="t m0 x14 h12 y28 ff2 fsb fc0 sc0 ls0 ws0">duas camadas <span class="lsc ws11">em<span class="_2 blank"></span><span class="ls0 ws0"> um processo denominado partição. </span></span></div><div class="t m0 x14 h11 y29 ff2 fsa fc0 sc0 ls0 ws0"> <span class="_d blank"></span>A<span class="_d blank"></span> <span class="_8 blank"> </span>razão <span class="_8 blank"> </span>entre <span class="_8 blank"> </span><span class="ls15 ws12">as</span> <span class="_8 blank"> </span>concentrações <span class="_8 blank"> </span><span class="ls8 ws13">do</span> <span class="_8 blank"> </span>soluto <span class="_8 blank"> </span><span class="ls8 ws13">nos</span> <span class="_8 blank"> </span>dois <span class="_8 blank"> </span>solventes <span class="_8 blank"> </span>é <span class="_e blank"> </span>uma </div><div class="t m0 x14 h12 y2a ff2 fsb fc0 sc0 ls0 ws0">constante <span class="_2 blank"></span><span class="ff6 ws10">K<span class="ff2 ws0">, denominada de <span class="ff6">coeficiente <span class="_2 blank"></span>de partição<span class="ff2"> </span></span></span></span></div><div class="t m0 x14 h10 y2b ff2 fs9 fc0 sc0 ls0 ws0"> </div><div class="t m0 x16 h13 y2c ff1 fsb fc0 sc0 ls0 ws0">K <span class="_f blank"> </span><span class="fsc ls16 v1">= <span class="ls10"> </span></span><span class="ws10 v2">C</span><span class="fsd ws14 v3">org</span><span class="v2"> </span></div><div class="t m0 x17 h14 y2d ff1 fsb fc0 sc0 ls0 ws10">C<span class="fsd ls13 ws15 v4">aq</span><span class="ws0"> </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg8.png"><div class="t m0 x18 h15 y2e ff1 fsc fc0 sc0 ls0 ws0">B) Ligados <span class="_2 blank"></span>ao fármaco<span class="_0 blank"></span> </div><div class="t m0 x18 h16 y2f ff2 fsd fc0 sc0 ls0 ws0"> </div><div class="t m0 x18 h17 y30 ff2 fse fc0 sc0 ls0 ws0"> </div><div class="t m0 x18 hc y31 ff2 fs4 fc0 sc0 ls0 ws0"> </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bg9.png"><div class="t m0 x14 h10 y32 ff2 fs9 fc0 sc0 ls19 ws16">A) <span class="ls0 ws0"> Fármac<span class="_2 blank"></span>os <span class="_0 blank"></span>liposso<span class="_0 blank"></span>lúveis: fácil <span class="_2 blank"></span>absorção<span class="_0 blank"></span> </span></div><div class="t m0 x14 h18 y33 ff2 fsf fc0 sc0 ls0 ws0">Ex.: difusão sim<span class="_2 blank"></span>ples </div><div class="t m0 x14 h10 y34 ff2 fs9 fc0 sc0 ls0 ws0"> </div><div class="t m0 x14 h10 y35 ff2 fs9 fc0 sc0 ls0 ws0">B) Fármac<span class="_2 blank"></span>os <span class="_0 blank"></span>hidros<span class="_0 blank"></span>solúveis: <span class="_2 blank"></span>maior dificuldade de absorção<span class="_10 blank"> </span> </div><div class="t m0 x14 h10 y36 ff3 fs9 fc0 sc0 ls17">\uf0d8<span class="ff2 ls0 ws0">necessitam <span class="_2 blank"></span>de transportes especializados<span class="_0 blank"></span> </span></div><div class="t m0 x14 h10 y37 ff2 fs9 fc0 sc0 ls0 ws0">Ex.: difusão facilitada </div><div class="t m0 x14 h14 y38 ff1 fsb fc2 sc0 ls0 ws0">Bicamada lipídica </div><div class="t m0 x19 h19 y39 ff1 fs10 fc0 sc0 ls0 ws0">Interior<span class="_2 blank"></span> hidr<span class="_2 blank"></span>ofóbico </div><div class="t m0 x1a h1a y3a ff1 fsf fc2 sc0 ls0 ws0">Fármacos: </div><div class="t m0 x1a hf y3b ff1 fs9 fc2 sc0 ls0 ws0">alto <span class="_11 blank"> </span>coeficiente <span class="_12 blank"> </span><span class="ls12 wsc">de</span> <span class="_12 blank"> </span>partição<span class="_0 blank"></span> <span class="_12 blank"> </span>(maio<span class="_0 blank"></span>r<span class="_2 blank"></span> </div><div class="t m0 x1a h1a y3c ff1 fsf fc2 sc0 ls0 ws0">afinidade <span class="_13 blank"> </span><span class="ls18 ws17">fase</span> <span class="_13 blank"> </span>orgânica) <span class="_14 blank"> </span>= </div><div class="t m0 x1a hf y3d ff1 fs9 fc2 sc0 ls0 ws0">ultrapassam<span class="_0 blank"></span> <span class="_15 blank"> </span>com <span class="_15 blank"> </span>maior<span class="_2 blank"></span> <span class="_15 blank"> </span>facilida<span class="_0 blank"></span>de <span class="_15 blank"> </span><span class="ls1a ws18">as</span> </div><div class="t m0 x1a hf y3e ff1 fs9 fc2 sc0 ls0 ws0">membranas <span class="_0 blank"></span>hidr<span class="_2 blank"></span>ofóbicas<span class="_0 blank"></span>. </div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x0 y0 w0 h0" alt="" src="https://files.passeidireto.com/e68fc532-4cea-4343-9198-c309c267536a/bga.png"><div class="t m0 x1b h14 y3f ff3 fsb fc0 sc0 ls1b">\uf0d8<span class="ff1 ls0 ws0">Modalidade <span class="_16 blank"> </span>mais <span class="_16 blank"> </span>fr<span class="_1 blank"></span>eqüente <span class="_16 blank"> </span><span class="ls1c ws19">de<span class="_0 blank"></span></span> <span class="_16 blank"> </span>absorção/distribuição <span class="_16 blank"> </span><span class="ls1c ws19">de</span> </span></div><div class="t m0 x1c h14 y40 ff1 fsb fc0 sc0 ls0 ws0">fármacos </div><div class="t m0 x1b h14 y41 ff3 fsb fc0 sc0 ls1b">\uf0d8<span class="ff1 ls0 ws0"> fármacos <span class="_17 blank"> </span>atravessam <span class="_17 blank"> </span>as <span class="_17 blank"> </span>membranas <span class="_15 blank"> </span>li<span class="_0 blank"></span>pídicas <span class="_15 blank"> </span><span class="ls1c ws19">na</span> <span class="_17 blank"> </span>forma <span class="_17 blank"> </span>não-</span></div><div class="t m0 x1c h14 y42 ff1 fsb fc0 sc0 ls0 ws0">ionizada (APOLAR) </div><div class="t m0 x1b h14 y43 ff3 fsb fc0 sc0 ls1b">\uf0d8<span class="ff1 ls0 ws0">A<span class="_d blank"></span> favor<span class="_2 blank"></span> <span class="ls1c ws19">do</span> gradiente <span class="ls1c ws19">de</span> concentração </span></div><div class="t m0 x1b h14 y44 ff3 fsb fc0 sc0 ls1b">\uf0d8<span class="ff1 ls0 ws0">Não <span class="ls1c ws19">há</span> gasto <span class="ls1c ws19">de</span> energia </span></div></div><div class="pi" data-data='{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}'></div></div>
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